bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estrogen Receptor-Related Receptor α Mediates Up-Regulation of Aromatase Expression by Prostaglandin E2 in Prostate Stromal Cells
Authors: Miao Lin , Shi Jiandang , Wang Chun-Yu , Zhu Yan , Du Xiaoling , Jiao Hongli , Mo Zengnan , Klocker Helmut , Lee Chung , Zhang Ju 
Published: March 2010

AbstractEstrogen receptor-related receptor α (ERRα) is an orphan member of the nuclear receptor superfamily of transcription factors. ERRα is highly expressed in the prostate, especially in prostate stromal cells. However, little is known about the regulation and function of ERRα, which may contribute to the progression of prostatic diseases. We previously found that prostaglandin E2 (PGE2) up-regulated the expression of aromatase in prostate stromal cells. Here we show that PGE2 also up-regulates the expression of ERRα, which, as a transcription factor, further mediates the regulatory effects of PGE2 on the expression of aromatase. ERRα expression was up-regulated by PGE2 in prostate stromal cell line WPMY-1, which was mediated mainly through the protein kinase A signaling pathway by PGE2 receptor EP2. Suppression of ERRα activity by chlordane (an antagonist of ERRα) or small interfering RNA knockdown of ERRα blocked the increase of expression and promoter activity of aromatase induced by PGE2. Overexpression of ERRα significantly increased aromatase expression and promoter activity, which were further augmented by PGE2. Chromatin immunoprecipitation assay demonstrated that ERRα directly bound to the aromatase promoter in vivo, and PGE2 enhanced the recruitment of ERRα and promoted transcriptional regulatory effects on aromatase expression in WPMY-1. 17β-Estradiol concentration in WPMY-1 medium was up-regulated by ERRα expression, and that was further increased by PGE2. Our results provided evidence that ERRα contributed to local estrogen production by up-regulating aromatase expression in response to PGE2 and provided further insights into the potential role of ERRα in estrogen-related prostatic diseases.
Forjando Patrimonio: The Making of Archaeological Patrimony in Porfirian Mexico
Authors: Bueno Christina 
Published: March 2010

Abstract
This article examines the state project to gather pre-Hispanic artifacts in Mexico’s National Museum during the dictatorship of Porfirio Díaz (1876–1910). It focuses on the government project as part of a larger effort aimed at constructing an official national history and image. Through antiquity and the control of its remains, Porfirian elites sought to present Mexico as a modern, scientific, and sovereign nation with a sophisticated, ancient past. They based the government’s right to the artifacts on arguments that rested on appeals to nation and science. This article problematizes these claims. It demonstrates that far from an established science, archaeology was marked by a lack of technique and consensus about the meaning and display of artifacts. In addition, the official Indian past proved exclusionary in several ways. It celebrated certain ancient cultures and ignored others. It also negated the artifacts’ other uses and meanings. For many Mexicans the objects were not national but local patrimony, links to localized identities and histories. Although ordinary Mexicans aided the state, the transfer of artifacts to the museum did not go uncontested, a fact illustrated here by popular struggles to retain objects in Teotihuacán, Tepoztlán, and Tetlama, communities that battled with the inspector of monuments Leopoldo Batres, the principal state official in charge of gathering antiquities.
The Birth of “Rok”: Cultural Imperialism, Nationalism, and the Glocalization of Rock Music in South Korea, 1964–1975
Authors: Kim Pil Ho , Shin Hyunjoon 
Published: March 2010

Like any other genre of Western popular music in the postwar period, rock was introduced to South Korea via the U.S. Armed Forces, a powerful symbol of postwar American hegemony. Until the late 1960s the U.S. military camp shows, clubs, and radio broadcast remained the main source of Western pop, providing opportunities for Korean musicians to hone their skills and enrich their repertoire. While this might be seen as a classic example of cultural imperialism, it actually developed a much more complex pattern of glocalization, especially in the case of rock music. The Korean appropriation of rock—which we refer to as “rok”—unfolded new sensibilities of the youth counterculture, mounting a considerable challenge to the conservative, militaristic nationalism of the Park Chung Hee regime.
The supremely talented guitarist and composer Shin Joong Hyun and his band, the Add Four, led the way from the U.S. military base to the Korean audience in 1964, along with their rivals, the Key Boys. Other Korean rock bands, then known as the “group sounds,” followed suit. Group-sound rok flourished in the live music salons, outdoor festivals, and go-go dance clubs, captivating the youth in the 1960s and 1970s. As the authoritarian regime started noticing and clamping down on the “threat” of the youth culture, Shin Joong Hyun and other group-sound musicians were making a breakthrough in the mainstream popular culture. In 1975 the regime banned and censored Shin and other musicians, criminalizing the youth culture.
In analyzing what sparked off this monumental culture clash, we find that rok's reimagination of nation as a community of peace and love caused the harsh reaction from the regime, whose doctrine of “national culture” was heavily influenced by the militaristic vision of the Japanese Empire.
A City of Ten Years: Public/Private Internet Development in Nanhai
Authors: Qiu Jack Linchuan 
Published: March 2010

Does the Internet, a key technological infrastructure in contemporary urban China, facilitate the emergence of private entrepreneurs and autonomous citizens? Who deserves the credit? Chinese national leaders answered “yes” to the first question and pointed to themselves as the answer to the second. This essay maintains, however, that local state actors played the central and effectively centralizing role in informatization (xinxihua) projects in Nanhai City, Guangdong province. Through local e-government projects and a series of policies regarding land use, financing, and personnel training, the Nanhai government was able to shape the emerging local e-conomy in a way that limited entrepreneurial autonomy for small-scale start-ups in the Internet industry. The highly centralized informatization campaign fundamentally reversed Nanhai's renowned decentralized model of rural industrialization.
Through this process, a fractured system emerged for the public and private meanings attached to informatization and to the city itself. This was manifested in everyday practice and discourse among local policymakers, entrepreneurs in both new and old economies, and average residents with different (mis)perceptions of the Internet influenced by their gender. At the formal policy level, the trend toward centralization was most obvious, revolving around the formation of a nebulous “public” network space being constructed by the city using technological, administrative, and rhetorical devices. Yet the “private” practices and perceptions of Internet that defined Nanhai's informational landscape persisted in a fractured manner at the same time, leading to major corruption scandals and the implosion of the grandiose technology campaign. To understand such a paradoxical process, this article examines the contextual and internal factors for Nanhai's Internet buildup. From a critical and historical perspective, it highlights a long-term seesaw battle along the problematic public-private borderline regarding issues of urbanization and informatization in contemporary Chinese cities.
This article reflects on the restructuring of local power relations and the role of “informatization” policy discourse therein. A crucial, yet often overlooked, dimension of reform in China today is the migration and subsequent transformation of technosocial meaning across different scales of public and private operations. The discursive process often has a transnational reach and tends to follow a political logic that usually only makes sense against the backdrop of the local history.
Consensus Methods to Identify a Set of Potential Performance Indicators for Systems of Emergency and Urgent Care
Authors: Coleman Patricia , Nicholl Jon 
Published: March 2010

Objectives To identify a comprehensive set of indicators to enable Primary Care Trust (PCT) commissioners in England and other NHS decision-makers to monitor the performance of systems of emergency and urgent care for which they are responsible. Methods Using a combination of Delphi RAND methods in three successive rounds of consultation and nominal group review, we canvassed expert opinion on 70 potential indicators as good measures of system performance. The two Delphi panels consisted of senior clinicians and researchers, and urgent care leads and commissioners in PCTs and Strategic Health Authorities (SHAs). The indicators were formatted into a questionnaire according to whether they were outcome, process, structure, or equity-based measures. Participants scored each indicator on a Likert scale of 1-9 and had the opportunity to consider their scores informed by the group scores and feedback. The questionnaire was refined after each round. To ensure that the indicators rated most highly by the Delphi panels covered all dimensions of performance, the results of the Delphi were reviewed by a nominal group consisting of two researchers and three clinicians from the local health services research network (LHSR). Results Overall, the process yielded 16 candidate indicators. It also produced a core set of serious, emergency and urgent care-sensitive conditions (defined as conditions whose exacerbations should be managed by a well-performing system without admission to an inpatient bed), for use with the indicators. Conclusions System-wide measures to monitor performance across multiple services should encourage providers to work for patient benefit in an integrated way. They will also assist commissioners to monitor and improve emergency and urgent care for their local populations. The indicators are now being calculated using routinely available data, and tested for their responsiveness to capture change over time.
Economic Consequences for Other Family Members of Mental Health Problems in Older People
Authors: Wilcox-Gök Virginia , McNamee Paul 
Published: March 2010

Objectives We estimated the effects of poor mental health among older family members on the labour supply and incomes of younger family members living in the same household. Due to policy differences, effects for Scotland were compared with other parts of the UK. Methods Effects were estimated using the British Household Panel Survey (waves 1999-2006), with data from621 older respondents and 800 younger family members. Mental health was assessed using the General Health Questionnaire (GHQ), together with self-reported presence of depression, anxiety, orothermental health problems. Results The associations between labour supply and mental ill-health were found to vary by gender and region of the UK. For men, there were larger negative effects in Scotland relative to the rest of the UK. For women, mental ill-health was associated with increased labour supply in Scotland, while in the remainder of the UK, a negative association was observed. Income losses accrued across all groups except among Scottish females, with the largest significant negative effects observed among men living in the remainder of the UK. Conclusions Mental health problems among older family members are associated with significant labour market effects for younger family members. To reduce the economic consequences, better assessment of mental health among older people may be warranted. Further employment support for younger family members, in the form of more flexible work policies, might also serve to ameliorate economic losses.
The Effect of Task-Specific Self-Efficacy on Stages of Change of People With Substance Abuse Problems
Authors: Cardoso Elizabeth Da Silva , Chou Chih Chin , Yasui Naoko Yura , Chronister Julie , Chan Fong , Lyons Valerie , Muller Veronica R. 
Published: March 2010

AbstractThe objective of the study was to determine the effect of task-specific self-efficacy on stages of readiness for change among people with substance abuse problems. Participants were 140 men and 33 women with substance abuse problems receiving services in outpatient therapeutic community service programs. The Stages of Change Scale-Substance Abuse (SCS-SA) was the outcome measure. People with substance abuse problems receiving outpatient treatment services can be meaningfully classified into four stages of change groups: (1) Precontemplation, (2) Inactive, (3) Ambivalent-Conforming, and (4) Participation. Readiness for change is related to self-efficacy in work-related skills and risk-avoidance skills. Task-specific self-efficacy is related to stages of change. The findings of this study suggested that providing skill training to enhance task specific self-efficacy can help people with substance abuse problems progress from lower level to higher level of stages of change.
Evaluating the Optimal City in South China for New Medical Facilities: The Application Modified Porter’s Diamond Framework
Authors: Lin Chin-Tsai , Tsai Meng-Chuan 
Published: March 2010

Abstract
This study presents the methods for modeling optimal city selection for new medical facilities in South China. This study has the objective of identifying the key criteria determining the relative advantages of different cities as a location for a new medical facility to help optimize the location of such facilities. The optimal city depends on various complex and interdependent criteria from the perspective of investors and managers. The weights of the multi-interrelationships criteria are assessed using the analytic network process (ANP) technique. Then, the values obtained for each city are determined using the technique for order preference by similarity to ideal solution utilizing the weights from ANP. Finally, Shenzhen was identified as the best city for a new facility.
Bayesian Inference of Genetic Parameters Based on Conditional Decompositions of Multivariate Normal Distributions
Authors: Hallander Jon , Waldmann Patrik , Wang Chunkao , Sillanpää Mikko J 
Published: March 2010

AbstractIt is widely recognized that the mixed linear model is an important tool for parameter estimation in the analysis of complex pedigrees, which includes both pedigree and genomic information, and where mutually dependent genetic factors are often assumed to follow multivariate normal distributions of high dimension. We have developed a Bayesian statistical method based on the decomposition of the multivariate normal prior distribution into products of conditional univariate distributions. This procedure permits computationally demanding genetic evaluations of complex pedigrees, within the user-friendly computer package WinBUGS. To demonstrate and evaluate the flexibility of the method, we analyzed two example pedigrees: a large noninbred pedigree of Scots pine (Pinus sylvestris L.) that includes additive and dominance polygenic relationships and a simulated pedigree where genomic relationships have been calculated on the basis of a dense marker map. The analysis showed that our method was fast and provided accurate estimates and that it should therefore be a helpful tool for estimating genetic parameters of complex pedigrees quickly and reliably.
Critical Determinants for Chromatin Binding by Saccharomyces cerevisiae Yng1 Exist Outside of the Plant Homeodomain Finger
Authors: Chruscicki Adam , MacDonald Vicki E , Young Barry P , Loewen Christopher J R , Howe LeAnn J 
Published: March 2010

Abstract
The temporal and spatial regulation of histone post-translational modifications is essential for proper chromatin structure and function. The Saccharomyces cerevisiae NuA3 histone acetyltransferase complex modifies the amino-terminal tail of histone H3, but how NuA3 is targeted to specific regions of the genome is not fully understood. Yng1, a subunit of NuA3 and a member of the Inhibitor of Growth (ING) protein family, is required for the interaction of NuA3 with chromatin. This protein contains a C-terminal plant homeodomain (PHD) finger that specifically interacts with lysine 4-trimethylated histone H3 (H3K4me3) in vitro. This initially suggested that NuA3 is targeted to regions bearing the H3K4me3 mark; however, deletion of the Yng1 PHD finger does not disrupt the interaction of NuA3 with chromatin or result in a phenotype consistent with loss of NuA3 function in vivo. In this study, we uncovered the molecular basis for the discrepancies in these data. We present both genetic and biochemical evidence that full-length Yng1 has two independent histone-binding motifs: an amino-terminal motif that binds unmodified H3 tails and a carboxyl-terminal PHD finger that specifically recognizes H3K4me3. Although these motifs can bind histones independently, together they increase the apparent association of Yng1 for the H3 tail.
The Experiences of Children Enrolled in Pediatric Oncology Research: Implications for Assent
Authors: Unguru Yoram , Sill Anne M. , Kamani Naynesh 
Published: March 2010

BACKGROUND:Most children with cancer enroll in clinical research trials. Whenever possible, children must provide their assent before enrolling in research studies. We studied what children aged 7 to 18 with cancer understand about research, their research-related treatment, and their preferences for inclusion in decision-making.PROCEDURE:Thirty-seven face-to-face, audiorecorded interviews using a novel, semi-structured tool, the quality-of-assent instrument, were conducted. Exploratory univariate and bivariate analyses of the quantitative data elucidated patterns and trends of understanding and preferences.RESULTS:Nineteen of the 37 children (51%) did not know or recall that their treatment was considered research, and 19 of 22 (86%) did not understand their doctor when he or she discussed the trial. More children enrolled in trials to help future children with cancer (27 of 37 [73%]), than to get better personally (22 of 37 [60%]). Irrespective of age, children with Hodgkin's disease, germ-cell tumors, and leukemia had significantly greater research awareness and appreciation than children with other cancers (P = .019 and P &lt; .001, respectively). Although all children wanted to be involved in decision-making, 18 of 37 (49%) did not have or recall having a role in deciding to enroll in their trial, and 14 of 37 (38%) did not feel free to dissent to trial enrollment. Only 4 of 37 children (11%) discussed increased decision-making roles with parents, and only 7 of 37 (19%) discussed them with their doctors.CONCLUSIONS:Most children have limited understanding of research despite physicians' explanations. Many children reported that they feel minimally involved in the decision to enroll in clinical trials. Tools to assist investigators ascertain that children understand what they are agreeing to when they assent to research and to determine their preferences for inclusion in research may help make assent more meaningful.
Changes in Neonatal Transfusion Practice After Dissemination of Neonatal Recommendations
Authors: Motta Mario , Testa Marcella , Tripodi Gino , Radicioni Maurizio 
Published: March 2010

OBJECTIVE:
To evaluate the change in neonatal transfusion practices after the introduction of national recommendations for transfusion of blood products to neonates in 2006.

METHODS:
A questionnaire-based survey on neonatal transfusion practice of 79 Italian NICUs was completed in 2008. Results were compared with those obtained from a previous national Italian neonatal transfusion-practice survey performed in 2001.

RESULTS:
Responses were received from 62 of 79 (78.5%) neonatal units. Prophylaxis for transfusion-transmitted cytomegalovirus infection in 2001 and 2008 had been performed in 96.8% and 98.4% of NICUs, respectively. Filter leukoreduction of red blood cell donor units was preferred over cytomegalovirus antibody testing to obtain cytomegalovirus-safe blood components. Prophylaxis for graft-versus-host disease increased from being performed at 61.3% of neonatal units in 2001 to 77.4% in 2008 (P = .08, Pearson χ2), whereas usage of dedicated red blood cell donor units (paedipack system), permitting multiple transfusions from the same unit, improved from 53.2% to 82.2% (P = .001, Pearson χ2). The 2008 survey documented a continuation of wide variability in transfusion practice for fresh-frozen plasma and platelet concentrates.

CONCLUSIONS:
This nation-wide Italian self-report survey highlighted improvements in NICU transfusion practice after the neonatal recommendations issued in 2006. Prophylaxis for transfusion-transmitted cytomegalovirus infection continued with nearly total adherence to national recommendations, and both prophylaxis for graft-versus-host disease and paedipack-system usage suggested a trend of improvement of adherence rates. The continuing wide diversity observed among neonatal units in fresh-frozen plasma and platelet-concentrate transfusion practice may indicate a lack of acceptable criteria for the administration of these blood products.
Emergency Information Forms and Emergency Preparedness for Children With Special Health Care Needs
Authors:   American Academy of Pediatrics,   Committee on Pediatric Emergency Medicine and Council on Clinical Information Technology,   American College of Emergency Physicians,   Pediatric Emergency Medicine Committee
Published: March 2010

This Policy Statement was revised. See https://doi.org/10.1542/peds.2022-060970.
Children with chronic medical conditions rely on complex management plans for problems that cause them to be at increased risk for suboptimal outcomes in emergency situations. The emergency information form (EIF) is a medical summary that describes medical condition(s), medications, and special health care needs to inform health care providers of a child's special health conditions and needs so that optimal emergency medical care can be provided. This statement describes updates to EIFs, including computerization of the EIF, expanding the potential benefits of the EIF, quality-improvement programs using the EIF, the EIF as a central repository, and facilitating emergency preparedness in disaster management and drills by using the EIF.
Health Equity and Children's Rights
Authors:   Council on Community Pediatrics and Committee on Native American Child Health
Published: March 2010

Many children in the United States fail to reach their full health and developmental potential. Disparities in their health and well-being result from the complex interplay of multiple social and environmental determinants that are not adequately addressed by current standards of pediatric practice or public policy. Integrating the principles and practice of child health equity—children's rights, social justice, human capital investment, and health equity ethics—into pediatrics will address the root causes of child health disparities.Promoting the principles and practice of equity-based clinical care, child advocacy, and child- and family-centered public policy will help to ensure that social and environmental determinants contribute positively to the health and well-being of children. The American Academy of Pediatrics and pediatricians can move the national focus from documenting child health disparities to advancing the principles and practice of child health equity and, in so doing, influence the worldwide practice of pediatrics and child health. All pediatricians, including primary care practitioners and medical and surgical subspecialists, can incorporate these principles into their practice of pediatrics and child health. Integration of these principles into competency-based training and board certification will secure their assimilation into all levels of pediatric practice.