bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantification of henatinib maleate, a novel potent inhibitor of VEGF receptors, in rat plasma by LC‐MS/MS
Authors: Gu Ping , Ding Ying , Sun Dezhu , Hang Taijun , Liu Wenying , Ding Li 
Published: August 2009

AbstractHenatinib maleate (R,Z)‐2‐[(5‐fluoro‐1,2‐dihydro‐2‐oxo‐3H‐indol‐3‐ylidene) methyl]‐5‐(2‐hydroxy‐3‐morpholinopropyl)‐3‐methyl‐5,6,7,8‐tetrahydro‐1H‐pyrrolo[3,2‐c] azepin‐4‐ketone maleate is a potent inhibitor of vascular endothelial growth factor receptors, and is currently under preclinical evaluation as an anticancer drug. A novel method for the quantification of henatinib maleate in rat plasma using high performance liquid chromatography–tandem mass spectrometry has been developed. The analyte (henatinib maleate) and internal standard (papaverine hydrochloride) were extracted from 50 μL of rat plasma by protein precipitation and separated on a C18 column using a mixture of 25 mm ammonium acetate buffer : methanol : acetonitrile (35 : 50 : 15, v/v/v) as mobile phase with a run time of 4.5 min. The detection was performed by means of triple quadrupole mass spectrometer equipped with an ESI interface operating in the multiple‐reaction monitoring mode. A linear response was observed over the concentration range 5.0–1000 ng/mL. The limit of quantification was 5.0 ng/mL. Both intra‐ and inter‐day precision, defined as relative standard deviation, were within 9.7%. Accuracy, defined as relative error, was within ± 3.1%. The developed method was successfully applied to preclinical pharmacokinetic studies of henatinib maleate in rat after a single oral administration of the drug. Copyright © 2009 John Wiley & Sons, Ltd.
A simple RP‐HPLC method for quantification of columbianadin in rat plasma and its application to pharmacokinetic study
Authors: Zhang You‐Bo , Yang Xiu‐Wei 
Published: August 2009

AbstractA rapid and sensitive reversed‐phase high‐performance liquid chromatographic (RP‐HPLC) method was developed to investigate pharmacokinetics of columbianadin, one of the main bioactive constituents in the roots of Angelica pubescens f. biserrata, in rat plasma after intravenous administration to rats at two doses of 10 and 20 mg/kg. The method involves a plasma clean‐up step using liquid–liquid extraction by diethyl ether, followed by RP‐HPLC separation and detection. Separation of columbianadin was performed on an analytical Diamonsil™ ODS C18 column, with a mobile phase of MeOH–H2O (85 : 15, v/v) at a flow‐rate of 1.0 mL/min, and UV detection was set at 325 nm. The retention time of columbianadin and scoparone (internal standard) was 6.7 and 3.5 min, respectively. The calibration curve was linear over the range of 0.2–20.0 μg/mL (r2 = 0.9986) in rat plasma. The lower limits of detection and quantification were 0.05 and 0.1 μg/mL, respectively. The extraction recovery from plasma was in the range of 81.61–89.93%. The intra‐ and inter‐day precisions (relative standard deviation) were between 1.01 and 9.33%, with accuracies ranging from 89.76 to 109.22%. The results indicated that the method established was suitable for the determination and pharmacokinetic study of columbianadin in rat plasma. Copyright © 2009 John Wiley & Sons, Ltd.
Alteration of the Diastereoselectivity of 3‐Methylaspartate Ammonia Lyase by Using Structure‐Based Mutagenesis
Authors: Raj Hans , Weiner Barbara , Puthan Veetil Vinod , Reis Carlos R. , Quax Wim J. , Janssen Dick B. , Feringa Ben L. , Poelarends Gerrit J. 
Published: August 2009

Abstract3‐Methylaspartate ammonia‐lyase (MAL) catalyzes the reversible amination of mesaconate to give both (2S,3S)‐3‐methylaspartic acid and (2S,3R)‐3‐methylaspartic acid as products. The deamination mechanism of MAL is likely to involve general base catalysis, in which a catalytic base abstracts the C3 proton of the respective stereoisomer to generate an enolate anion intermediate that is stabilized by coordination to the essential active‐site MgII ion. The crystal structure of MAL in complex with (2S,3S)‐3‐methylaspartic acid suggests that Lys331 is the only candidate in the vicinity that can function as a general base catalyst. The structure of the complex further suggests that two other residues, His194 and Gln329, are responsible for binding the C4 carboxylate group of (2S,3S)‐3‐methylaspartic acid, and hence are likely candidates to assist the MgII ion in stabilizing the enolate anion intermediate. In this study, the importance of Lys331, His194, and Gln329 for the activity and stereoselectivity of MAL was investigated by site‐directed mutagenesis. His194 and Gln329 were replaced with either an alanine or arginine, whereas Lys331 was mutated to a glycine, alanine, glutamine, arginine, or histidine. The properties of the mutant proteins were investigated by circular dichroism (CD) spectroscopy, kinetic analysis, and 1H NMR spectroscopy. The CD spectra of all mutants were comparable to that of wild‐type MAL, and this indicates that these mutations did not result in any major conformational changes. Kinetic studies demonstrated that the mutations have a profound effect on the values of kcat and kcat/KM; this implicates Lys331, His194 and Gln329 as mechanistically important. The 1H NMR spectra of the amination and deamination reactions catalyzed by the mutant enzymes K331A, H194A, and Q329A showed that these mutants have strongly enhanced diastereoselectivities. In the amination direction, they catalyze the conversion of mesaconate to yield only (2S,3S)‐3‐methylaspartic acid, with no detectable formation of (2S,3R)‐3‐methylaspartic acid. The results are discussed in terms of a mechanism in which Lys331, His194, and Gln329 are involved in positioning the substrate and in formation and stabilization of the enolate anion intermediate.
Results of percutaneous drug‐eluting stent implantation for unprotected left main coronary disease according to left ventricular systolic function
Authors: Bollati Mario , Gerasimou Argyrios , Sillano Dario , Biondi‐Zoccai Giuseppe , Garrone Paolo , Moretti Claudio , Sciuto Filippo , Omedé Pierluigi , Trevi Gian Paolo , Sheiban Imad 
Published: August 2009

AbstractObjectives: We aimed to appraise the early and long‐term outcome after percutaneous coronary intervention (PCI) with drug‐eluting stents (DES) in patients with unprotected left main disease (ULM) and left ventricular systolic dysfunction (LVD). Background: PCI with DES has being performed with increasing frequency in subjects with ULM and LVD, but few specific data are available. Setting and Patients: We identified patients undergoing PCI with DES for ULM at our Center and distinguished those with ejection fraction (EF) >50% from those with 40% <EF ≤50% and those with EF ≤40%. The primary end‐point was the rate of major adverse cerebro‐cardiovascular events (MACCE, ie death, myocardial infarction [MI], stroke, repeat PCI or bypass surgery). Results: A total of 197 patients were included, 57.4% with EF >50%, 32.0% with 40% <EF ≤50%, and 10.6% with EF ≤40%. In‐hospital mortality was significantly higher in those with EF ≤40% (9.5% vs. 0 and 3.2%, P < 0.001). A total of 96% patients were followed for 23 ± 14 months, yielding a MACCE rate of 44.2% (41.6% in those with EF >50%, 41.6% in those with 40% <EF ≤50%, and 61.9% in those with EF ≤40%, P = 0.4). Specifically, death occurred in 2.7%, 7.9%, and 28.6% (P < 0.001), cardiac death in 1.8%, 4.8%, and 23.8% (P = 0.001), MI in 8.0%, 7.9% and 0 (P = 0.4), and TVR in 15.9%, 11.1% and 33.3% (P = 0.6). Conclusion: Systolic ventricular dysfunction is highly correlated with in‐hospital and long term death rates in patients undergoing PCI with DES for ULM disease. However it does not confer an increased risk of nonfatal adverse events or stent thrombosis. © 2009 Wiley‐Liss, Inc.
Use of the sheathless guide catheter during routine transradial percutaneous coronary intervention: A feasibility study
Authors: Mamas Mamas , D'Souza Savio , Hendry Cara , Ali Razwan , Iles‐Smith Heather , Palmer Karen , El‐Omar Magdi , Fath‐Ordoubadi Farzin , Neyses Ludwig , Fraser Douglas G. 
Published: August 2009

AbstractObjective: The aim of this study is to investigate the feasibility of using a 6.5 Fr sheathless guide catheter as a default system in transradial (TRA) percutaneous coronary intervention (PCI). Background: TRA PCI has been shown to reduce mortality rates through a reduction in access site related bleeding complications compared with procedures performed though a femoral approach. Complications associated with the TRA route increase with the size of sheath used. These complications may be reduced by the use of a sheathless guide catheter system (Asahi Intecc, Japan) that is 1–2 Fr sizes smaller in diameter than the corresponding introducer sheath. Methods: We performed PCI in 100 consecutive cases using 6.5 Fr sheathless guides to determine the procedural success, rates of symptomatic radial spasm and radial occlusion. Results: Procedural success using the 6.5 Fr sheathless guide catheter system was 100% with no cases requiring conversion to a conventional guide and catheter system. There were no procedural complications recorded associated with the use of the catheter. Adjunctive devices used in this cohort included IVUS, stent delivery catheters, distal protection devices, and simple thrombectomy catheters. The rate of radial spasm was 5% and the rate of radial occlusion at 2 months was 2%. Conclusion: Use of the 6.5 Fr sheathless guide catheter system, which has an outer diameter <5 Fr sheath, as the default system in routine PCI is feasible with a high rate of procedural success via the radial artery. © 2009 Wiley‐Liss, Inc.
Catalytic Combustion of Toluene over a Copper‐Manganese‐Silver Mixed‐Oxide Catalyst Supported on a Washcoated Ceramic Monolith
Authors: Zhou J.‐C. , Wu D.‐F. , Jiang W. , Li Y.‐D. 
Published: August 2009

AbstractMonolithic catalysts were prepared by washcoating an alumina sol and then impregnating Cu‐Mn‐Ag mixed oxides onto cordierite substrates. The effects of the preparation parameters including the Ag/Cu/Mn ratio, the total amount of active phase and the loading of washcoat, and the reaction conditions, e.g., the space velocity and the oxygen/toluene ratio on the catalytic performance for the combustion of toluene were investigated. It is shown that the Cu‐Mn‐Ag oxides are very active for the combustion of toluene and that the highest catalytic activity is achieved over a monolithic catalyst containing 14.7 wt % of washcoat and 21.2 wt % of active phase with a Ag/Cu/Mn molar ratio of 13.8/43.1/43.1. It is also seen that the optimum catalyst has a good catalytic stability and exhibits an excellent activity not only at a rather high space velocity but also within a wide range of oxygen/toluene ratios.
2,6,8‐Trisubstituted 3‐Hydroxychromone Derivatives as Fluorophores for Live‐Cell Imaging
Authors: Dyrager Christine , Friberg Annika , Dahlén Kristian , Fridén‐Saxin Maria , Börjesson Karl , Wilhelmsson L. Marcus , Smedh Maria , Grøtli Morten , Luthman Kristina 
Published: August 2009

AbstractWe present the synthesis and photophysical characterisation of a series of structurally diverse, fluorescent 2,6,8‐trisubstituted 3‐hydroxychromone derivatives with high fluorescence quantum yields and molar extinction coefficients. Two of these derivatives (9 and 10 a) have been studied as fluorophores for cellular imaging in HeLa cells and show excellent permeability and promising fluorescence properties in a cellular environment. In addition, we have demonstrated by photophysical characterisation of 3‐isobutyroxychromone derivatives that esterification of the 3‐hydroxyl group results in acceptable and useful fluorescence properties.
Alternating Ring‐Opening Metathesis Copolymerization by Grubbs‐Type Initiators with Unsymmetrical N‐Heterocyclic Carbenes
Authors: Lichtenheldt Martin , Wang Dongren , Vehlow Kati , Reinhardt Ingrid , Kühnel Christa , Decker Ulrich , Blechert Siegfried , Buchmeiser Michael R. 
Published: August 2009

AbstractA series of RuIV–alkylidenes based on unsymmetrical imidazolin‐2‐ylidenes, that is, [RuCl2{1‐(2,4,6‐trimethylphenyl)‐3‐R‐4,5‐dihydro‐(3H)‐imidazol‐1‐ylidene}(CHPh)(pyridin)] (R=CH2Ph (5), Ph (6), ethyl (7), methyl (8)), have been synthesized. These and the parent initiators [RuCl2(PCy3){1‐(2,4,6‐trimethylphenyl)‐3‐R‐4,5‐dihydro‐(3H)‐imidazol‐1‐ylidene}(CHC6H5)] (R=CH2C6H5 (1), C6H5 (2), ethyl (3)) were used for the alternating copolymerization of norborn‐2‐ene (NBE) with cis‐cyclooctene (COE) and cyclopentene (CPE), respectively. Alternating copolymers, that is, poly(NBE‐alt‐COE)n and poly(NBE‐alt‐CPE)n containing up to 97 and 91 % alternating diads, respectively, were obtained. The copolymerization parameters of the alternating copolymerization of NBE with CPE under the action of initiators 1–3 and 5–8 were determined by using both a zero‐ and first‐order Markov model. Finally, kinetic investigations using initiators 1–3, 6, and 7 were carried out. These revealed that in contrast to the 2nd‐generation Grubbs‐type initiators 1–3 the corresponding pyridine derivatives 6 and 7 represent fast and quantitative initiating systems. Hydrogenation of poly(NBE‐alt‐COE)n yielded a fully saturated, hydrocarbon‐based polymer. Its backbone can formally be derived by 1‐olefin polymerization of CPE (1,3‐insertion) followed by five ethylene units and thus serves as an excellent model compound for 1‐olefin polymerization‐derived copolymers.
The Three‐Component Biginelli Reaction: A Combined Experimental and Theoretical Mechanistic Investigation
Authors: De Souza Rodrigo O. M. A. , da Penha Eduardo T. , Milagre Humberto M. S. , Garden Simon J. , Esteves Pierre M. , Eberlin Marcos N. , Antunes Octavio A. C. 
Published: August 2009

AbstractBiginelli reactions have been monitored by direct infusion electrospray ionization mass spectrometry (ESI‐MS) and key cationic intermediates involved in this three‐component reaction have been intercepted and further characterized by tandem MS experiments (ESI‐MS/MS). Density functional theory calculations were also used to investigate the feasibility of the major competing mechanisms proposed for the Biginelli reaction. The experimental and theoretical results were found to corroborate the iminium mechanism proposed by Folkers and Johnson, whereas no intermediates directly associated with either the more energy demanding Knoevenagel or enamine mechanisms could be intercepted.
ChemInform Abstract: Crystal Structure and Magnetic Properties of Novel Intermetallic Compounds in the Er—Cu—Ga System.
Authors: Belgacem B. , Pasturel M. , Tougait O. , Potel M. , Roisnel T. , Hassen R. Ben , Noel H. 
Published: August 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Crystal Structure of Na2Mg2NiH6 Revisited.
Authors: Oriova Maria , Rapin Jean‐Philippe , Yvon Klaus 
Published: August 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Phase Equilibria in the Quasi‐ternary System Ag2S—In2S3—CdS at 870 K.
Authors: Kozer V. R. , Fedorchuk A. , Olekseyuk I. D. , Parasyuk O. V. 
Published: August 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Difluoro‐λ5‐phosphinonitrile F2PN: Matrix Isolation and Photoisomerization into FP=NF.
Authors: Zeng Xiaoqing , Beckers Helmut , Willner Helge 
Published: August 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A New Type of 1‐D Thioindates, [M(en)3]0.5[InS2] (M: Co, Ni), Synthesized by Solvothermal Reaction.
Authors: Zhou Jian , Zhang Yong , Zhang Ming‐Hui , Lei Zhi‐Xin , Dai Jie 
Published: August 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Quaternary Gd4Ni2Sb1.+‐.xSi2.+‐. x and Gd4Ni2Bi1.+‐.xSi2.+‐. x: Crystal Structure, Homogeneity Regions and Magnetic Behavior.
Authors: Svitlyk Volodymyr , Fei Fan , Kracher Alfred , Mozharivskyj Yurij 
Published: August 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Organocatalytic Asymmetric Synthesis of Chiral Fluorinated Quaternary Carbon Containing β‐Ketoesters.
Authors: Li Hao , Zhang Shilei , Yu Chenguang , Song Xixi , Wang Wei 
Published: August 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Catalytic Asymmetric Ring‐Opening Reaction of meso‐Epoxides with Aryl Selenols and Thiols Catalyzed by a Heterobimetallic Gallium—Titanium—Salen Complex.
Authors: Sun Jiangtao , Yang Minghua , Yuan Fang , Jia Xuefeng , Yang Xia , Pan Yi , Zhu Chengjian 
Published: August 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: α‐Pinene‐Based New Chiral Ionic Liquids and Their Application as Phase Transfer Catalysts in Enantioselective Addition of Diethylzinc to Aldehydes.
Authors: Malhotra Sanjay V. , Wang Yun , Kumar Vineet 
Published: August 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Nickel Complexes of N/O‐Functionalized N‐Heterocyclic Carbenes as Precatalysts for Michael Reactions in Air at Room Temperature under the Much Preferred Base‐Free Conditions
Authors: Ray Sriparna , Shaikh Mobin M. , Ghosh Prasenjit 
Published: August 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Copper‐Catalyzed N‐Arylation of Hindered Substrates under Mild Conditions.
Authors: Wentzel Michael T. , Hewgley J. Brian , Kamble Rajesh M. , Wall Philip D. , Kozlowski Marisa C. 
Published: August 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Rare [(NHC)2Ni‐OH]‐Type Terminal Nickel Hydroxo and [(NHC)2Ni]‐Type Complexes of N/O‐Functionalized N‐Heterocyclic Carbenes as Precatalysts for Highly Desirable Base‐Free Michael Reactions in Air at Ambient Temperature.
Authors: Samantaray Manoja K. , Shaikh Mobin M. , Ghosh Prasenjit 
Published: August 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Stereoselective Synthesis of Polysubstituted Alkenes Through a Phosphine‐Mediated Three‐Component System of Aldehydes, α‐Halo Carbonyl Compounds and Terminal Alkenes.
Authors: Liu Da‐Neng , Tian Shi‐Kai 
Published: August 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Concise Synthesis of Non‐Protein Amino Acid from Natural Product via Schmidt Reaction.
Authors: Gajcy Kamila , Librowski Tadeusz , Lochynski Stanislaw 
Published: August 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Sequential Copper‐Catalyzed Rearrangement—Allylic Substitution of Bicyclic Hydrazines with Grignard Reagents.
Authors: Crotti Stefano , Bertolini Ferruccio , Macchia Franco , Pineschi Mauro 
Published: August 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Asymmetric Organocatalytic Domino Michael/Aldol Reactions: Enantioselective Synthesis of Chiral Cycloheptanones, Tetrahydrochromenones, and Polyfunctionalized Bicyclo[3.2.1]octanes.
Authors: Rueping Magnus , Kuenkel Alexander , Tato Francisco , Bats Jan W. 
Published: August 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Catalyzed Imidation of Tertiary Amines by Simple Copper Salts.
Authors: Liu Nan , Tang Bo‐Yang , Chen Yue , He Ling 
Published: August 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.