bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Resins and Linkers for Solid‐Phase Synthesis of Small Molecules
Authors: Blackburn Christopher , Albericio Fernando , Kates Steven A. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Enaminones: Useful Starting Materials for the Preparation of Heterocycles
Authors: Cimarelli Cristina , Palmieri Gianni 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Recent Improvements for the Preparation and Synthetic Applications of β‐Nitroenones
Authors: Schneider Raphael , Gerardin Philippe , Ahrach Mohammed , Boelle Jerome , Loubinoux Bernard 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Properties of Resin Supports and Their Effects on Solid‐Phase Organic Synthesis
Authors: Yan Bing 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: RPR′s Approach to High‐Speed Parallel Synthesis for Lead Generation
Authors: Labaudiniere Richard F. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: 1‐Hydroxyindoles
Authors: Somei Masanori 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Cadmium Therapeutic Agents
Authors: Kelley Colleen , Sargent David E. , Uno Jennifer K. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Novel Concepts in Directed Biaryl Synthesis. Part 78. The Lactone Concept: An Efficient Pathway to Axially Chiral Natural Products and Useful Reagents
Authors: Bringmann Gerhard , Breuning Matthias , Tasler Stefan 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Reductive Amination of Oxygen‐Containing Organic Compounds
Authors: Tarasevich V. A. , Kozlov N. G. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Levulinic acid in Organic Synthesis
Authors: Timokhin B. V. , Baransky V. A. , Eliseeva G. D. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Chiral 3,6‐Dihydro‐2H‐1,4‐oxazin‐2‐ones as Alanine Equivalents for the Asymmetric Synthesis of α‐Methyl α‐Amino Acids (AMAAs) under Mild Reaction Conditions
Authors: Chinchilla Rafael , Galindo Nuria , Najera Carmen 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Chemical Models of Protein β‐Sheets
Authors: Nowick James S. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of 3′‐C‐ and 4′‐C‐Branched Oligodeoxynucleotides and the Development of Locked Nucleic Acid (LNA)
Authors: Wengel Jesper 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Spiroepoxycyclohexa‐2,4‐dienones in Organic Synthesis
Authors: Singh Vishwakarma 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Synthetic and Structural Chemistry of Heme Derivatives with Nitric Oxide Ligands
Authors: Scheidt W. Robert , Ellison Mary K. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Separation and Analysis of Saccharides — On Mainly Oligosaccharides
Authors: Koizumi Kyoko 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Cell‐Selective, Apoptosis‐inducing Rhodium(III) Crown Thiaether Complexes
Authors: Bieda Ruth , Dobroschke Mara , Triller Annika , Ott Ingo , Spehr Marc , Gust Ronald , Prokop Aram , Sheldrick William S. 
Published: June 2010

AbstractHalf‐sandwich rhodium(III) polypyridyl (pp) complexes with the metal atom capped by the facial crown thiaether 1,4,7‐trithiacyclononane [9]aneS3 represent a promising class of apoptosis‐inducing potent cytostatic agents. The necrotic damage caused by the complexes is negligible. In vitro cytotoxicity assays with the human cancer cell lines MCF‐7 and HT‐29 and immortalized HEK‐293 cells indicate that the dicationic κ2N(imino) complexes [([9]aneS3)RhCl(pp)]2+ are much more active than monocationic complexes [([9]aneS3)RhCl2(L)]+ (L=imidazole, CH3CN). Whereas the κ2N(amino) complex [([9]aneS3)RhCl(piperazine)]2+ is inactive, replacing piperazine with the structurally analogous κ2S (thiaether) ligand 1,4‐dithiane restores cytotoxicity as evidenced by IC50 values in the range 8.1‐11.6 μM. Spectroscopic (CD, UV/Vis, NOESY) and viscosity measurements indicate that the active dppz complex 8 (IC50 values: 4.7–8.9 μM) exhibits strong intercalative binding towards DNA whereas the even more potent bipyrimidine complex 9 (IC50 values: 0.6–1.9 μM) causes no alteration of the duplex B conformation. Weaker intercalative binding is observed for the dpq complex 7. A comparative annexin V–propidium iodide binding assay with lymphoma (BJAB) cells and healthy leukocytes demonstrates that the cytotoxic activity of complex 8 and particularly complex 9 is highly selective towards the malignant cells.
Predictors of anticoagulation in hospice patients with lung cancer
Authors: Holmes Holly M. , Bain Kevin T. , Zalpour Ali , Luo Ruili , Bruera Eduardo , Goodwin James S. 
Published: June 2010

AbstractBACKGROUND:Guidelines recommend lifelong anticoagulation in patients with cancer and a history of thromboembolism, but the use of anticoagulation in hospice has not been described. A retrospective study of medication data was conducted to determine patterns of anticoagulant use and predictors of type of anticoagulant prescribed for hospice patients with lung cancer.METHODS:Medication data were evaluated for 16,896 hospice patients with lung cancer in 2006 to determine patient and hospice characteristics that predicted anticoagulant prescription. Independent predictors of warfarin versus low molecular weight heparin (LMWH) prescription were identified using a logistic regression model.RESULTS:One of every 11 patients was prescribed an anticoagulant, most commonly warfarin. Compared with patients prescribed LMWH, patients prescribed warfarin were older (71.6 vs 65.8 years, P<.001), were more likely white (81.2% vs 74.3%, P = .03), had a longer stay in hospice (median 21 days vs 17 days, P = .001), and were more likely to have ≥3 comorbid illnesses (37.5% vs 25.0%, P<.001). The strongest independent predictor of type of anticoagulant prescribed was geographic region, with hospices in the Northeast more likely to prescribe LMWH.CONCLUSIONS:Anticoagulant use is prevalent in patients with lung cancer enrolled in hospice. This study highlights the need to understand the benefits and risks of anticoagulation at the end of life. Cancer 2010. © 2010 American Cancer Society.
Activity and tolerability of nilotinib
Authors: Koren‐Michowitz Maya , le Coutre Philipp , Duyster Justus , Scheid Christof , Panayiotidis Panayiotis , Prejzner Witold , Rowe Jacob M. , Schwarz Michaela , Goldschmidt Neta , Nagler Arnon 
Published: June 2010

AbstractBACKGROUND:Nilotinib is active in imatinib‐resistant and ‐intolerant chronic myeloid leukemia patients and was recently approved for these indications.METHODS:Data on the efficacy and safety of nilotinib treatment were collected from 2 phase 2 expanded access clinical trials with similar designs (CAMN107AIL01 and ENACT).RESULTS:Of 88 study patients (58 chronic, 11 accelerated, 19 blast crisis), the best responses to nilotinib were complete hematologic response (CHR) in 27%, partial cytogenetic response in 12%, complete cytogenetic response in 14%, and major molecular response in 19%. Patients achieving at least a CHR during imatinib therapy were more likely to respond to nilotinib, and failure to achieve at least a CHR on imatinib therapy was predictive of progression or lack of response to nilotinib (P = .0021). Responses were not statistically different in subgroup analysis, including that of imatinib intolerance compared with imatinib resistance, presence of ABL kinase domain mutations compared with absence of mutations, and previous treatment with another second‐generation tyrosine kinase inhibitor compared no prior treatment. The overall survival and progression‐free survival rates at 1 year were 83% and 48% for the entire cohort, 93% and 66% in chronic phase, and 64% and 19% in advanced phase. Adverse hematological events included thrombocytopenia (all events, 27%; grade 3‐4, 13%) and leukopenia (all events, 18%; grade 3‐4, 10%). The majority of the nonhematological events were mild, the most common being rash, infection, bone pain, headache, nausea, and vomiting.CONCLUSIONS:Nilotinib treatment is an efficient and safe therapy for imatinib‐resistant or ‐intolerant patients. Prior response to imatinib therapy is a predictor for the response to nilotinib. Cancer 2010. © 2010 American Cancer Society.
Interim report of a phase 2 clinical trial of lenalidomide for T‐cell non‐Hodgkin lymphoma
Authors: Dueck Greg , Chua Neil , Prasad Angeli , Finch Daygen , Stewart Doug , White Darrell , van der Jagt Richard , Johnston James , Belch Andrew , Reiman Tony 
Published: June 2010

AbstractBACKGROUND:Novel therapies are needed to improve outcomes in T‐cell lymphomas. The authors report the interim results of a prospective multicenter trial evaluating lenalidomide in T‐cell lymphomas.METHODS:Patients with recurrent and refractory T‐cell lymphomas other than mycosis fungoides and untreated patients ineligible for combination chemotherapy were prescribed oral lenalidomide (25 mg daily) on Days 1 to 21 of each 28‐day cycle until disease progression, death, or unacceptable toxicity. The primary endpoint was overall response rate. Secondary endpoints were progression‐free survival (PFS), overall survival (OS), and safety. The 2‐stage design allows for up to 40 patients.RESULTS:At the time of this interim analysis, 24 patients were enrolled in this study, and 23 were evaluable for response. The median age was 65 years. The overall response rate was 7 (30%) of 23; all were partial responses. Two patients had stable disease for ≥5 cycles. Responses were seen in anaplastic, angioimmunoblastic, and peripheral T‐cell unspecified histologies. Median PFS was 96 days (range, 8‐696+ days). Median OS was 241 days (range, 8‐696+ days). The most common grade 4 adverse event was thrombocytopenia (33%). The most common grade 3 adverse events were neutropenia (21%), febrile neutropenia (17%), and pain not otherwise specified (17%). Rash correlated with response to therapy (P = .003).CONCLUSIONS:In patients with recurrent and refractory T‐cell lymphomas, oral lenalidomide monotherapy has clinical activity, and toxicity is consistent with the known safety profile of lenalidomide. Further study of lenalidomide in these diseases is warranted. Cancer 2010. © 2010 American Cancer Society.
Utility of the GeneSearch breast lymph node assay for the rapid evaluation of sentinel lymph nodes in breast cancer
Authors: Funasako Yawara , Uenosono Yoshikazu , Hirata Munetsugu , Arigami Takaaki , Yanagita Shigehiro , Arima Hideo , Ehi Katsuhiko , Kijima Yuko , Yoshinaka Heiji , Natsugoe Shoji 
Published: June 2010

AbstractBACKGROUND:The potential for reducing the need for second surgery for axillary lymph node dissection (ALND) has made the intraoperative evaluation of sentinel lymph nodes (SLNs) attractive. The goal of the current study was to evaluate the clinical application of the breast lymph node (BLN) assay, a real‐time reverse transcriptase‐polymerase chain reaction assay for SLN metastases, by comparing this test with routine pathologic examination.METHODS:A total of 117 patients with breast cancer underwent breast surgery with SLN biopsy. Each SLN was cut in half along the plane of the longest dimension. Half of each lymph node was examined by the 2 markers of the BLN assay, mammaglobin and cytokeratin 19, and the other half was examined by hematoxylin and eosin staining (H&E) and immunohistochemical staining (IHC) for pancytokeratins.RESULTS:A total of 204 SLNs were obtained from 117 patients. H&E staining identified metastases in 31 SLNs (15.2%), and IHC staining detected metastases in 6 SLNs; 40 SLNs from 32 patients were found to be positive for metastasis using the BLN assay. The assay results were correlated with the pathologic diagnoses by H&E and IHC staining (P <.001). The sensitivity of the BLN assay compared with pathologic findings classified according to the TNM classification was 95.7% for macrometastases, 60.0% for micrometastases, and 55.6% for isolated tumor cells.CONCLUSIONS:The 2‐marker BLN assay performs in a manner that is comparable to, and analyzes more tissue than, routine pathologic examination. Therefore, clinical intraoperative use of the BLN assay for SLNs may result in a reduction in the need for second surgery for ALND. Cancer 2010. © 2010 American Cancer Society.
Comparison of Trap‐state Distribution and Carrier Transport in Nanotubular and Nanoparticulate TiO2 Electrodes for Dye‐Sensitized Solar Cells
Authors: Mohammadpour Raheleh , Iraji zad Azam , Hagfeldt Anders , Boschloo Gerrit 
Published: June 2010

AbstractDye‐sensitized solar cells (DSCs) with nanotubular TiO2 electrodes of varying thicknesses are compared to DSCs based on conventional nanoparticulate electrodes. Despite the higher degree of order in one‐dimensional nanotubular electrodes, electron transport times and diffusion coefficients, determined under short‐circuit conditions, are comparable to those of nanoparticulate electrodes. The quasi‐Fermi level, however, is much lower in the nanotubes, suggesting a lower concentration of conduction band electrons. This provides evidence for a much higher diffusion coefficient for conduction band electrons in nanotubes than in nanoparticulate films. The electron lifetime and the diffusion length are significantly longer in nanotubular TiO2 electrodes than in nanoparticulate films. Nanotubular electrodes have a trap distribution that differs significantly from nanoparticulate electrodes; they possess relatively deeper traps and have a characteristic energy of the exponential distribution that is more than two times that of nanoparticulate electrodes.
Local Disorder in Hydrogen Storage Compounds: The Case of Lithium Amide/Imide
Authors: Ludueña Guillermo A. , Wegner Martin , Bjålie Lars , Sebastiani Daniel 
Published: June 2010

AbstractAmides and imides of alkali metals are a very promising class of materials for use as a hydrogen‐storage system, as they are able to store and release hydrogen via a chemical route at controllable temperatures and pressures. We critically revise the present picture of the atomic structure of the lightest member (LiNH2/Li2NH) by using a combined computational and experimental approach. Specifically, ab initio path integral molecular dynamics simulations and solid‐state 1H NMR techniques are combined. The results show that the presently assumed local structure might be inconsistent or at least incomplete and needs considerable revision. In particular, the Li atoms turn out to be more mobile and more disordered than suggested by structural data obtained from X‐ray scattering. Also, the configuration of the hydrogen atoms, which is accessible via the NMR experiment and the corresponding first‐principles calculations, is different from the previously assumed data. The computed and experimentally observed 1H NMR parameters are in very good mutual agreement and illustrate the unusual chemical environment of the hydrogen atoms in this system. Incorporating our results on the new lithium data, we show that the effect of nuclear quantum delocalization for the hydrogen atoms is considerably reduced compared to the perfect crystal structure.
Distance estimation to multiple targets using band‐limited noise signal
Authors: Uebo Tetsuji , Nakasako Noboru , Ohmata Norimitsu , Itagaki Hanae 
Published: June 2010

AbstractIn many engineering fields, the distance to target is fundamental and very important information. Acoustical signals, such as audible sound or ultrasound, often play an essential role in measurement of distance. To measure distance, the time delay of the reflected wave measured with reference to the transmitted pulse wave, that is, the time‐of‐flight (TOF), is typically used. However, this method cannot measure short distances because the transmitted wave, which has not attenuated enough at the time of reception of the reflected waves, suppresses the reflected waves for a short distance. Meanwhile, in microwave radar research, a novel method using standing waves has been recently proposed in order to measure the distances to multiple targets, even if short. We apply the fundamental principle of this method to the estimation of short distances for multiple targets using audible sound. In this paper, we focus our attention on audible band‐limited noise. To verify the validity and effectiveness of our method, we perform computer simulations and experiments. It is confirmed that short distances to multiple targets, such as the distances to two targets located 0.1 and 1 m away, can be estimated properly by our method. © 2010 Wiley Periodicals, Inc. Electron Comm Jpn, 93(7): 53–60, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/ecj.10248
Variation of transpiration within a canopy of silver birch: effect of canopy position and daily versus nightly water loss
Authors: Sellin Arne , Lubenets Kristina 
Published: June 2010

AbstractSap flux density (FLA) in branches of Betula pendula trees was examined with respect to environmental variables and canopy position. FLA of branches sampled within the basal and top thirds of crowns was analysed with respect to stomatal (gs), canopy (gc) and soil‐to‐leaf hydraulic conductance (KT). The canopy positions differed significantly (P < 0·001) by FLA: the day‐time values in the upper canopy were on average 1·8 times greater than in the lower canopy (59·2 vs 33·2 g m−2 h−1), associated with greater gs, gc and KT observed in the upper canopy. The differences in gc among the canopy positions resulted primarily from a ∼10‐fold greater aerodynamic boundary‐layer conductance (gbl) in the upper canopy (mean gbl was 1695 vs 161 mmol m−2 s−1, respectively) in the day time. The asymptotic nature of gs versus gc relationship observed in the lower canopy suggests that stomata limit transpiration from the shade foliage at higher gbl. The linear relationship (R2 = 0·49–0·58, P < 0·001) between KT and FLA alludes to the role of hydraulic capacity in the control of sap fluxes. The dominant environmental factor affecting FLA in the day time was irradiance, and air relative humidity at night. The strong dependence of FLA on atmospheric evaporative demand in the night time proved that nocturnal branch sap flow indeed represents transpiration, but not tissue water recharge. Nocturnal FLA was about 24·7 and 19·5% of the respective mean day‐time rates for the upper and lower canopy. Owing to short northern nights in summer, nocturnal transpiration constituted only 6–8% of the daily total water loss. The variation in branch‐level sap flow is determined not merely by environmental gradients existing within the forest canopy, but depends largely on trees' internal properties, including stomatal conductance and plant hydraulic properties. Copyright © 2010 John Wiley & Sons, Ltd.