bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design and implementation of a 2.8‐dB insertion loss v‐band bandpass filter in 0.13‐μm cmos technology
Authors: Lin Chih‐Ying , Chang Jin‐Fa , Lin Yo‐Sheng 
Published: May 2012

AbstractIn this article, we demonstrate a low‐insertion‐loss V‐band bandpass filter with two finite transmission zeros by 0.13‐μm CMOS technology. The proposed filter architecture has the following feature: The low‐frequency transmission‐zero (ωz1) can be tuned individually by the series‐feedback capacitor Cs and the series capacitor C3. After ωz1 is determined by Cs and C3, the high‐frequency transmission zero (ωz2) can be tuned individually by the parallel‐feedback capacitor Cp. Besides, low‐insertion‐loss is achieved by adopting thick microstrip‐line with optimized ground‐plane pattern as the needed inductors to minimize the metal and substrate loss. This filter achieves insertion‐loss (1/S21) lower than 3 dB over the frequency range of 45–52 GHz, input return loss (S11) better than −10 dB over the frequency range of 41.2–57.8 GHz, and output return loss (S22) better than −10 dB over the frequency range of 39.5–55.9 GHz. The minimum insertion‐loss is 2.8 dB at 48 GHz, to the authors' knowledge, this is one of the best results ever reported for a V‐band CMOS bandpass filter in the literature. The chip area is only 0.295 × 0.21 mm2, i.e., 0.062 mm2, excluding the test pads and dummy metals for design rule requirement. © 2012 Wiley Periodicals, Inc. Microwave Opt Technol Lett 54:2001–2006, 2012; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26984
Accurate computations of matrices with bidiagonal decomposition using methods for totally positive matrices
Authors: Barreras A. , Peña J. M. 
Published: May 2012

SUMMARYA class of sign‐symmetric P‐matrices including all nonsingular totally positive matrices and their inverses as well as tridiagonal nonsingular H‐matrices is presented and analyzed. These matrices present a bidiagonal decomposition that can be used to obtain algorithms to compute with high relative accuracy their singular values, eigenvalues, inverses, or their LDU factorization. Copyright © 2012 John Wiley & Sons, Ltd.
A unified 3D‐based technique for plate bending analysis using scaled boundary finite element method
Authors: Man H. , Song C. , Gao W. , Tin‐Loi F. 
Published: May 2012

SUMMARYThis paper presents a unified technique for solving the plate bending problems by extending the scaled boundary finite element method. The formulation is based on the three‐dimensional governing equation without enforcing the kinematics of plate theory. Only the in‐plane dimensions are discretised into finite elements. Any two‐dimensional displacement‐based elements can be employed. The solution along the thickness is expressed analytically by using a matrix function. The proposed technique is consistent with the three‐dimensional theory and applicable to both thick and thin plates without exhibiting the numerical locking phenomenon. Moreover, the use of higher order spectral elements allows the proposed technique to better represent curved boundaries and to achieve high accuracy and fast convergence. Numerical examples of various plate structures with different thickness‐to‐length ratios demonstrate the applicability and accuracy of the proposed technique. Copyright © 2012 John Wiley & Sons, Ltd.
An improved quantitative mass spectrometry analysis of tumor specific mutant proteins at high sensitivity
Authors: Ruppen‐Cañás Isabel , López‐Casas Pedro P. , García Fernando , Ximénez‐Embún Pilar , Muñoz Manuel , Morelli M. Pia , Real Francisco X. , Serna Antonio , Hidalgo Manuel , Ashman Keith 
Published: May 2012

New disease specific biomarkers, especially for cancer, are urgently needed to improve individual diagnosis, prognosis, and treatment selection, that is, for personalized medicine. Genetic mutations that affect protein function drive cancer. Therefore, the detection of such mutations represents a source of cancer specific biomarkers. Here we confirm the implementation of the mutant protein specific immuno‐SRM (where SRM is selective reaction monitoring) mass spectrometry method of RAS proteins reported by Wang et al. [Proc. Natl. Acad. Sci. USA 2011, 108, 2444–2449], which exploits an antibody to simultaneously capture the different forms of the target protein and the resolving power and sensitivity of LC‐MS/MS and improve the technique by using a more sensitive mass spectrometer. The mutant form G12D was quantified by SRM on a QTRAP 5500 mass spectrometer and the MIDAS workflow was used to confirm the sequence of the targeted peptides. This assay has been applied to quantify wild type and mutant RAS proteins in patient tumors, xenografted human tissue, and benign human epidermal tumors at high sensitivity. The limit of detection for the target proteins was as low as 12 amol (0.25 pg). It requires low starting amounts of tissue (ca.15 mg) that could be obtained from a needle aspiration biopsy. The described strategy could find application in the clinical arena and be applied to the study of expression of protein variants in disease.
Synthesis of syndiotactic‐rich star‐shaped poly(methyl methacrylate) by core‐first group transfer polymerization using N‐(trimethylsilyl)bis(trifluoromethanesulfonyl)imide
Authors: Chen Yougen , Takada Kenji , Fuchise Keita , Satoh Toshifumi , Kakuchi Toyoji 
Published: May 2012

AbstractThe N‐(trimethylsilyl)bis(trifluoromethanesulfonyl)imide‐catalyzed (Me3SiNTf2‐catalyzed) group transfer polymerization (GTP) of methyl methacrylate (MMA) has been studied for synthesizing stereospecific star‐shaped poly(methyl methacrylate)s (PMMAs). The catalytic property of Me3SiNTf2 for the GTP of MMA using 1‐methoxy‐1‐trimethylsilyloxy‐2‐methyl‐propene as the initiator was confirmed by a kinetic investigation and matrix‐assisted laser desorption ionization time‐of‐flight mass spectrometry measurement. The initiating efficiency (f) of Me3SiNTf2 was 0.94–1.00, which was estimated by the value of Mn(calcd)/Mn(SEC). The Me3SiNTf2‐catalyzed GTP of MMA was carried out using initiators possessing three, four, and six MTS groups (MTS3, MTS4, and MTS6, respectively) under the condition of [MMA]0/[MTS3, MTS4, or MTS6]0 = 120 at −55 °C. All the obtained PMMAs exhibited unimodal and narrow molecular weight distributions as Mw/Mns = 1.03–1.04 and the Mw(MALS)s of the 3‐, 4‐, and 6‐armed star‐shaped PMMAs (PMMA3, PMMA4, and PMMA6, respectively) were 12.9, 12.9, and 13.4 kgmol−1, respectively, which fairly agreed with the calculated Mw(calcd) values. The syndiotacticities, rrs, of PMMA3, PMMA4, and PMMA6 were in the range of 87–89%. The stereoblock synthesis of PMMA3, PMMA4, and PMMA6 was performed by the first and second polymerizations at −55 and 45 °C; the rrs of the first and second PMMA blocks were 87.0, 87.0, and 86.0% and 65.0, 65.0, and 64.0%, respectively. The glass transition temperatures (Tgs) were 118.1, 115.8, and 111.5 °C for the respective syndiotactic‐rich PMMA3, PMMA4, and PMMA6 and 111.5, 109.7, and 107.6 °C for the respective stereoblock ones. © 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2012
Sensing the messenger: The diverse ways that bacteria signal through c‐di‐GMP
Authors: Krasteva Petya Violinova , Giglio Krista Michelle , Sondermann Holger 
Published: May 2012

AbstractAn intracellular second messenger unique to bacteria, c‐di‐GMP, has gained appreciation as a key player in adaptation and virulence strategies, such as biofilm formation, persistence, and cytotoxicity. Diguanylate cyclases containing GGDEF domains and phosphodiesterases containing either EAL or HD‐GYP domains have been identified as the enzymes controlling intracellular c‐di‐GMP levels, yet little is known regarding signal transmission and the sensory targets for this signaling molecule. Although limited in number, identified c‐di‐GMP receptors in bacteria are characterized by prominent diversity and multilevel impact. In addition, c‐di‐GMP has been shown to have immunomodulatory effects in mammals and several eukaryotic c‐di‐GMP sensors have been proposed. The structural biology of c‐di‐GMP receptors is a rapidly developing field of research, which holds promise for the development of novel therapeutics against bacterial infections. In this review, we highlight recent advances in identifying bacterial and eukaryotic c‐di‐GMP signaling mechanisms and emphasize the need for mechanistic structure–function studies on confirmed signaling targets.
Age‐dependent deamidation of glutamine residues in human γS crystallin: Deamidation and unstructured regions
Authors: Hooi Michelle Yu Sung , Raftery Mark J. , Truscott Roger John Willis 
Published: May 2012

AbstractHuman aging is associated with the deterioration of long‐lived proteins. Gradual cumulative modifications to the life‐long proteins of the lens may ultimately be responsible for the pronounced alterations to the optical and physical properties that characterize lenses from older people. γS crystallin, a major human lens protein, is known to undergo several age‐dependent changes. Using proteomic techniques, a site of deamidation involving glutamine 92 has been characterized and its time course established. The proportion of deamidation increased from birth to teen‐age years and then plateaud. Deamidation at this site increased again in the eighth decade of life. There was no significant difference in the extent of deamidation between cataract and age‐matched normal lenses. Gln92 is located in the linker region between the two domains, and the introduction of a negative charge at this site may alter the interaction between the two regions of the protein. Gln170, which is located in another unstructured part of γS crystallin, showed a similar deamidation profile to that of Gln92. As the other Gln residues in β‐sheet regions of γS crystallin appear to remain as amides, modification of Gln92 and Gln170 thus conforms to a pattern whereby deamidation is localized to the unstructured regions of long‐lived proteins.
Piperlongumine induces rapid depletion of the androgen receptor in human prostate cancer cells
Authors: Golovine Konstantin V. , Makhov Peter B. , Teper Ervin , Kutikov Alexander , Canter Daniel , Uzzo Robert G. , Kolenko Vladimir M. 
Published: May 2012

AbstractBACKGROUNDAndrogen receptor (AR) signaling is regarded as the driving force in prostate carcinogenesis, and its modulation represents a logical target for prostate cancer (PC) prevention and treatment. Natural products are the most consistent source of small molecules for drug development. In this study, we investigate the functional impact of piperlongumine (PL), a naturally occurring alkaloid present in the Long pepper (Piper longum), on AR expression in PC cells and delineate its mechanism of action.METHODSExpression and transcriptional activity of AR was examined by western blotting and luciferase reporter assay, respectively. CellTiter Blue assay was utilized to quantify cell proliferation. Reactive oxygen species (ROS) generation was examined by staining cells with a ROS indicator CM‐H2DCFDA, followed by flow cytometry analysis.RESULTSThe results of our experiments demonstrate that PL rapidly reduces AR protein levels in PC cells via proteasome‐mediated ROS‐dependent mechanism. Moreover, PL effectively depletes a modified AR lacking the ligand‐binding domain, shedding light on a new paradigm in the treatment approach to prostatic carcinoma that expresses mutated constitutively active AR. Importantly, PL effectively depletes AR in PC cells at low micromolar concentrations, while concurrently exerting a significant inhibitory effect on AR transcriptional activity and proliferation of PC cells.CONCLUSIONSOur investigation demonstrates for the first time that PL induces rapid depletion of the AR in PC cells. As such, PL may afford novel opportunities for both prevention and treatment of prostatic malignancy. Prostate 73: 23–30, 2013. © 2012 Wiley Periodicals, Inc.
Optical and photoluminescence properties of BiFeO3 thin films grown on ITO‐coated glass substrates by chemical solution deposition
Authors: Chen Xinman , Zhang Hu , Wang Tao , Wang Feifei , Shi Wangzhou 
Published: May 2012

AbstractThe optical and photoluminescence properties of the pure bismuth ferrite (BiFeO3) thin films deposited on ITO‐coated glass substrates by chemical solution deposition methods were investigated. The optical bandgap of obtained BiFeO3 thin films annealed at 500 and 600 °C were confirmed to be 2.75 and 2.71 eV, respectively. The dependence of bandgap on annealing was discussed in terms of coarsening grain sizes as well as the existence of amorphous phases in the films. Furthermore, the evident photoluminescence of BiFeO3 thin films is observed. The near‐band‐edge emission located at 455.4 and 457.9 nm were identified for BiFeO3 thin films annealed at 500 and 600 °C, respectively, while the identical defect emission at 468.7 and 492.3 nm were confirmed for both BiFeO3 thin films, which were tentatively attributed to the defect states related with Bi3+ level and oxygen deficiencies inside the bandgap. However, more investigations are needed to classify the origin of BiFeO3 thin‐film emission for further application.
Cubic materials in different auxetic regions: Linking microscopic to macroscopic formulations
Authors: Brańka A. C. , Heyes D. M. , Maćkowiak Sz. , Pieprzyk S. , Wojciechowski K. W. 
Published: May 2012

AbstractA number of basic features of the mechanical properties of a cubic symmetry solid material are identified and discussed within the framework of the XY‐plane approach, where X = G/K, Y = G/W, K is the bulk modulus and G, W are shear moduli. An anisotropic part of the Debye temperature is analysed, which was found to be weakly dependent on X and is mainly determined by Y which quantifies the material elastic anisotropy. The anisotropic part has a considerable effect on the Debye temperature of partially auxetic materials. An empirical ductility‐brittleness criterion is considered, which indicates that many auxetics may deform in a brittle manner. A possible correlation between directional tensile deformation and the surface of the most extreme Poisson's ratio (PR) values is suggested. Finally, the reasons for the paucity of cubic materials in the part of the XY‐plane with low Y values is investigated using static microscopic models in which the particles interact with nearest and next nearest neighbours only. An example of a type of microscopic model system located in this ‘empty’ region has been found, which consists of a system under tension, where the interparticle interaction decays with distance in an oscillatory way. The results obtained suggest that a rather unconventional form of the interparticle interaction set and thermodynamic conditions may therefore be required to develop a solid material with these mechanical properties.
Designing offshore fish cages using systems engineering principles
Authors: Shainee Mohamed , Haskins Cecilia , Ellingsen Harald , Leira Bernt J. 
Published: May 2012

AbstractThe human population reached 7 billion at the end of October 2011, accentuating the challenge to increase food production to meet the demand. Offshore mariculture, which does not depend on wild fish harvest, has the potential to become a primary food source to meet this demand. Despite an overall interest and justification in investments in offshore aquaculture, there are very few offshore cage designs suitable for use today. The goal of the current paper is to describe a research project that applied systems engineering principles to develop and document a set of requirements and identify the relevant technical components that are needed to design a sustainable offshore cage system. Requirements from the sector should be met by a robust environmentally friendly cage system ensuring the welfare of the fish and capable of producing a quality fish product demanded by the consumer. Future design work will build on the proposed preliminary architecture to satisfy these requirements. © 2012 Wiley Periodicals, Inc. Syst Eng
Unified theories of cognition
Authors: Byrne Michael D. 
Published: May 2012

AbstractUnified theories of cognition (UTCs) offer an alternative to the modal ‘divide and conquer’ methodology within cognitive science and attempt to address the full range of cognitive activity within a single theoretical framework. These theories, also termed ‘cognitive architectures’ are generally computational in nature and are intended to model, at some degree of fidelity, human cognition in a broad range of tasks. This style of research has numerous advantages, not the least of which being that the actual human cognitive system is itself an integrated system and many important tasks require bringing integrated capabilities to bear. There are also drawbacks, particularly dealing with the incompleteness of the knowledge base in cognitive science and the difficulty of evaluating such theories. Three architectures are profiled, each one representing a different ‘home’ discipline: from AI, Soar; from cognitive psychology, Adaptive Control of Thought‐Rational; and from neuroscience, Leabra. Future directions for UTCs include expansion into branches of cognition not already well represented, such as spatial cognition, and increasing attention to cognitive moderators such as emotion and fatigue. Overall, this is a powerful research strategy that is likely to remain an important part of cognitive science for the foreseeable future. WIREs Cogn Sci 2012, 3:431–438. doi: 10.1002/wcs.1180This article is categorized under:

Computer Science > Neural Networks
The Barium Oxotellurate(IV) Bromides Ba6Te10O25Br2 and Ba3Te3O8Br2 with Channel Structures
Authors: Stöger Berthold , Weil Matthias 
Published: May 2012

AbstractTwo new barium oxotellurate(IV) bromides with sum formula Ba6Te10O25Br2 and Ba3Te3O8Br2 were obtained under hydrothermal conditions and were characterized by single‐crystal X‐ray diffraction. In the crystal structures of both compounds a three‐dimensional Ba/Te/O network is perforated by channels, into which the lone pairs E of the TeIV atoms protrude and in which the Br– anions are located. Ba6Te10O25Br2 {Aea2, Z = 8, a = 11.4707(9) Å, b = 31.140(2) Å, c = 18.3216(14) Å, 9331 F2 data, 392 variable parameters, R[F2 > 2σ(F2)] = 0.0376} can be described as a fourfold super structure derived from an idealized basic structure in space group Pmmn. The main building blocks of the super structure are nine crystallographically independent [TeO3+1] units and one trigonal‐pyramidal [TeO3] unit, which share corners and edges to form wavy layers parallel to (001) that are connected by seven independent Ba2+ ions. The three independent Br– anions are situated in channels parallel to [100], leading to overall coordination numbers of the cations ranging from eight to eleven. In the crystal structure of Ba3Te3O8Br2 {Pnma, Z = 4, a = 12.6226(8) Å, b = 5.9663(4) Å, c = 18.1112(12) Å, 5897 F2 data, 88 variable parameters, R[F2 > 2σ(F2)] = 0.0260} the oxotellurate(IV) anions consist of an isolated [TeO3] unit and a condensed [Te2O5]2– group. They coordinate to the three independent Ba2+ ions to form channels extending parallel to [010]. The overall coordination number of all cations is eight whereby each of them is bonded at least to one of the two independent Br– anions in the channels in the form of distorted coordination polyhedra.
Strengthening Mechanisms in NiAl Bronze: Hot Deformation by Rolling and Friction-Stir Processing
Authors: Menon Sarath K. , Pierce Frank A. , Rosemark Brian P. , Oh-Ishi Keiichiro , Swaminathan Srinivasan , McNelley Terry R. 
Published: May 2012

Abstract
Microstructures produced by isothermal hot rolling of a NiAl bronze material were evaluated by quantitative microscopy methods and parameters describing the contributions of precipitate dispersions, grain size, solute content, and dislocation density to the yield strengths of the individual constituents of microstructure were determined. Models for the strengths of the individual constituents were combined to predict the temperature dependence of the yield strength as a function of hot rolling temperature, and the prediction was found to be in good agreement with measured yield strengths. The models were applied to microstructures in a stir zone produced by multipass friction-stir processing (FSP) and, again, found to predict measured yield strengths with high accuracy. Such models may aid in assessing the role of microstructure gradients produced during FSP and other processes.
Forgetting mechanisms for scalable collaborative filtering
Authors: Vinagre João , Jorge Alípio Mário 
Published: May 2012

AbstractCollaborative filtering (CF) has been an important subject of research in the past few years. Many achievements have been made in this field, however, many challenges still need to be faced, mainly related to scalability and predictive ability. One important issue is how to deal with old and potentially obsolete data in order to avoid unnecessary memory usage and processing time. Our proposal is to use forgetting mechanisms. In this paper, we present and evaluate the impact of two forgetting mechanisms—sliding windows and fading factors—in user-based and item-based CF algorithms with implicit binary ratings under a scenario of abrupt change. Our results suggest that forgetting mechanisms reduce time and space requirements, improving scalability, while not significantly affecting the predictive ability of the algorithms.
The “see and treat” strategy for identifying cytologic high‐grade precancerous cervical lesions among low‐income Brazilian women
Authors: Nogara Paula R.B. , Manfroni Luís A.R. , da Silva Mariana C. , Consolaro Marcia E.L. 
Published: May 2012

AbstractObjectiveTo evaluate the strategy of “see and treat” by loop electrosurgical excision procedure (LEEP) for cytologic high‐grade precancerous cervical lesions (squamous intraepithelial lesions; HSIL) and post‐LEEP recurrence among low‐income Brazilian women.MethodsIn a retrospective survey of women who underwent LEEP for cytologic HSIL without prior cervical biopsy between January 2004 and March 2008 at CISVALI, União da Vitória, Paraná, Brazil, LEEP sample histology and patient follow‐up by Papanicolaou smear were assessed.ResultsAmong 117 women treated, 24% had no lesions, 67.5% had cervical intraepithelial neoplasia (CIN) grade 2/3, and 5.2% had squamous cell carcinoma or adenocarcinoma on LEEP histology. Among patients with follow‐up, recurrences occurred in those with no lesions (16.7%) and CIN 2/3 (25%) (P > 0.05). HSIL was the most frequent type of recurrence (87%) (P < 0.001). In total, 6.3% of patients had positive ectocervical (ecto‐positive) and endocervical (endo‐positive) margins, 3.8% had ecto‐positive, and 33.0% had endo‐positive margins. Recurrences occurred in women with endo‐positive (26.3%), no margin (17.4%), and cautery artifact margin (25.0%) involvement (P > 0.05).ConclusionFor cytologic HSIL, the benefits of the strategy of “see and treat” by LEEP outweighed the risk of overtreatment. Patients with both positive and negative margins on LEEP should be followed carefully.