bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neuropathic pain during treatment for childhood acute lymphoblastic leukemia
Authors: Anghelescu Doralina L. , Faughnan Lane G. , Jeha Sima , Relling Mary V. , Hinds Pamela S. , Sandlund John T. , Cheng Cheng , Pei Deqing , Hankins Gisele , Pauley Jennifer L. , Pui Ching‐Hon 
Published: February 2011

AbstractBackgroundImproved cure rates for childhood acute lymphoblastic leukemia (ALL) over the past 2 decades have allowed greater attention to patients' quality of life. Neuropathic pain (NP) is an unpleasant side effect of chemotherapeutic agents for leukemia, especially vincristine.ProcedureWe retrospectively reviewed the records of 498 patients treated on a single protocol for ALL to investigate the risk factors, the incidence, and the use of therapeutic and prophylactic gabapentin treatment for NP.ResultsWhite non‐Hispanic race was the only patient variable predictive of NP. One hundred and seventy‐four of 498 patients (34.9%) experienced 207 episodes of NP; 16% (28 of 174) patients experienced at least one recurrence of pain after the initial episode. No statistical significance was found in the relation between the severity (grade) of the NP episode and the cumulative dose of vincristine (P = 0.45) or the vincristine dose that immediately preceded the diagnosis (1.5 mg/m2 versus 2.0 mg/m2 [correction made here after initial online publication], P = 0.59). Of 180 episodes with treatment data, 62.2% (112) and 37.8% (68) were treated with gabapentin or opioids, respectively. The selection of treatment with gabapentin or opioids was not influenced by the pain intensity score at the time of diagnosis of NP (P = 0.91). The mean gabapentin dose used for 112 episodes was 15.5 mg/kg/day (SD 7.9). We found no evidence that gabapentin prevented recurrence of NP.ConclusionsOur results highlight the need for prospective randomized studies to elucidate the value of gabapentin regimen for prevention or treatment of vincristine‐related pain during treatment of childhood leukemia. Pediatr Blood Cancer 2011; 57: 1147–1153. © 2011 Wiley Periodicals, Inc.
Use of sentinel node biopsy for staging parameningeal rhabdomyosarcoma
Authors: Weiss Brian D. , Dasgupta Roshni , Gelfand Michael J. , Laor Tal , Yin Hong , Breneman John C. , Lavigne Ruth , Elluru Ravindhra G. , Wagner Lars M. 
Published: February 2011

AbstractIdentification of nodal involvement is important for treatment planning in patients with rhabdomyosarcoma, and is facilitated by sentinel node biopsy. Although it is employed primarily for extremity tumors, we report using sentinel node biopsy in a patient with parameningeal rhabdomyosarcoma arising in the ethmoid sinus. Lymphoscintigraphy with single photon emission computed tomography following injection of tracer at the tumor site helped identify contralateral cervical node involvement not previously recognized by physical exam, cross sectional imaging, or other functional imaging. This case demonstrates how information from sentinel node identification and biopsy can change therapy recommendations in patients with parameningeal rhabdomyosarcoma. Pediatr Blood Cancer 2011; 57: 520–523. © 2011 Wiley‐Liss, Inc.
Siblings presenting with progressive congenital aleukemic leukemia cutis
Authors: Agrawal Anurag K. , Guo Hua , Golden Carla 
Published: February 2011

AbstractCongenital leukemia is infrequent, occurring in <1% of pediatric leukemia patients, and mainly of myeloid lineage. Twenty‐five to 30% of congenital leukemia cases present with cutaneous leukemic infiltrates. Rarely, infants will have aleukemic leukemia cutis, presenting with leukemic skin lesions but without systemic symptoms or bone marrow involvement. Few cases of congenital aleukemic leukemia cutis have been reported in the literature. The course of disease is variable as cases of spontaneous resolution have been described. Here we present the first report of siblings with progressive congenital aleukemic leukemia cutis, both treated successfully with myeloid leukemia chemotherapy. Pediatr Blood Cancer 2011; 57: 338–340. © 2011 Wiley‐Liss, Inc.
Laser desorption ionisation–time of flight mass spectrometry of the tolyporphins, bioactive metabolites from the cyanobacterium Tolypothrix nodosa
Authors: Prinsep Michèle R. , Puddick Jonathan 
Published: February 2011

AbstractIntroduction – The tolyporphins are metabolites isolated from the cyanobacterium Tolypothrix nodosa, comprising a porphyrin‐like macrocycle with C‐glycoside, hydroxide or acetate substituents. Previous studies of porphyrins by MALDI/LDI‐TOF MS indicate that strong radical cations and anions are usually observed in the parent spectra with little fragmentation of the macrocycle. The spectra of the tolyporphins were obtained and trends in the series utilised to partially characterise two new analogues.Objective – To examine tolyporphins by LDI‐TOF MS and utilise trends observed to partially characterise two new analogues.Methodology – The tolyporphins were analysed by LDI‐TOF MS in positive and negative ion mode and by a post source decay method (LIFT) in positive ion mode. Tolyporphin A was also analysed by MALDI‐TOF MS for comparison. Results were analysed and used to obtain structural information on two new analogues.Results and Discussion – The resulting spectra generally contained intense radical cations or anions, with little fragmentation of the macrocyclic core or the C‐glycosides observed. These results are consistent with previous studies of porphyrins. Major fragment ions observed in LIFT spectra yielded key structural information. An inseparable mixture of two tolyporphins was also examined. Analysis of the LIFT spectrum of the parent ion resulted in the postulation of structures of these two new analogues.Conclusions – Tolyporphins yield LDI‐TOF mass spectra somewhat analogous to those of porphyrins; furthermore, the substituents fragment in a characteristic manner permitting partial characterisation of the new analogues tolyporphins L and M by comparison of their LDI‐TOF mass spectra with those of the known analogues. Copyright © 2011 John Wiley & Sons, Ltd.
Selective ethylene‐permeable zeolite composite double‐layered film for novel modified atmosphere packaging
Authors: Monprasit P. , Ritvirulh C. , Sooknoi T. , Rukchonlatee S. , Fuongfuchat A. , Sirikittikul D. 
Published: February 2011

AbstractThe composite double‐layered films, for the packaging application of postharvest fruits and vegetables, were prepared by laminating low‐density polyethylene (LDPE) and poly[styrene‐b‐(ethylene‐co‐butylene)‐b‐styrene] (SEBS) modified with zeolite ZSM‐5. The film was characterized by scanning electron microscope and differential scanning calorimeter and tested for permeation of ethylene (C2H4), oxygen (O2), carbon dioxide (CO2), and water vapor. It was found that the C2H4 permeability of the films was improved because of an enhanced adsorption of C2H4 by the incorporated zeolite (0–10 wt%). The preconcentrated layer (zeolite/SEBS) leads to a higher C2H4 concentration gradient across the film. Moreover, the high dispersion of zeolite increased the C2H4 permeation. When compared with O2 and CO2, the composite films were more selective to C2H4. However, the C2H4 permeation decreased in the presence of O2 because of a competitive adsorption. In addition, the films possessed appreciate tensile properties for packaging application. POLYM. ENG. SCI., 2011. © 2011 Society of Plastics Engineers
Preparation and properties of bitumen modified with the maleic anhydride grafted styrene‐butadiene‐styrene triblock copolymer
Authors: Cong Peiliang , Chen Shuanfa , Chen Huaxin 
Published: February 2011

AbstractA procedure to improve the properties of styrene‐butadiene‐styrene (SBS) copolymer modified bitumen by grafting of maleic anhydride (MAH) onto SBS in the presence of benzoyl peroxide (BPO) as initiator was proposed. The effects of the grafting degree (GD) on the properties of modified bitumen were investigated. FTIR spectroscopy was employed to verify the grafting of MAH onto SBS. The GD of MAH onto SBS was determined by a back titration procedure. To assess the effects of the GD of grafted SBS on properties of modified bitumen, the softening point, penetration, ductility, elastic recovery, penetration index, viscosity, storage stability, and dynamic shear properties were tested. Experimental results indicated that the SBS grafted with maleic anhydride (SBS‐g‐MAH) copolymer was successfully synthesized by solvothermal method, and different GD of the SBS‐g‐MAH was obtained by control the MAH concentration. The GD of the MAH onto SBS has great effect on the rheological properties of the modified bitumen, and the high temperature performance and storage stability of modified bitumen were improved with the GD of the MAH onto SBS increasing. POLYM. ENG. SCI., 2011. © 2011 Society of Plastics Engineers
Newly designed polyacrylamide/dextran gels for electrophoresis protein separation: synthesis and characterization
Authors: Ainseba‐Chirani Naziha , Dembahri Zahra , Tokarski Caroline , Rolando Christian , Benmouna Mustapha 
Published: February 2011

AbstractNewly designed gels for electrophoresis protein separation were synthesized from acrylamide, N,N′‐methylenebis (acrylamide) and dextran mixtures. Radical polymerization was initiated by ammonium persulfate and N,N,N′,N′‐tetramethylethylenediamine. The time dependence of absorbance during polymerization was monitored using UV‐visible spectroscopy. The exothermic polymerization process exhibited a sharp rise of temperature reminiscent of the Trommsdorff effect. The swelling kinetics of the synthesized gels was examined in deionized water and buffer solutions. One of the challenges was to find an alternative to commercial products, sold as mixtures with no detailed chemical contents, commonly used in sodium dodecylsulfate polyacrylamide gel electrophoresis (SDS‐PAGE) for protein separation. For this reason, a systematic comparison was made of the properties of one of the most commonly used commercial gels, Duracryl™ from Genomics Solution Inc., and those of the synthesized polyacrylamide/dextran gels. Copyright © 2011 Society of Chemical Industry
Basic hydrolysis of quinolinyl N,N‐dimethylcarbamates: a two‐step mechanism
Authors: Silva Daniel , Norberto Fátima , Santos Susana , Iley Jim 
Published: February 2011

AbstractThe reactivity of 6‐quinolinyl and 8‐quinolinyl N,N‐dimethylcarbamates was examined in several aqueous basic media. A quadratic dependence was observed for the constant rates upon hydroxide concentration for both compounds, which is a typical behaviour of a mechanism involving a base‐catalysed deprotonation of the tetrahedral intermediate with the formation of a dianion at high concentrations of hydroxide ion, while at lower concentrations a specific‐base catalysed addition–elimination mechanism seems to be predominant. The reactivity of 8‐quinolinyl N,N‐dimethylcarbamate was also studied in several amine buffers, showing specific base catalysis. The reactivity of 6‐quinolinyl N,N‐dimethylcarbamate was studied in H2O and in D2O and the solvent isotope effect supports the proposal of a mechanism involving a specific‐base hydrolysis. All results confirm the existence of a mechanism with a rate determining step involving the substrate anion and a second mole of hydroxide ion. This mechanism was so far unknown for carbamate reactivity, being only known to occur with amides. Copyright © 2011 John Wiley & Sons, Ltd.
β‐Elimination of an aziridine to an allylic amine: a mechanistic study
Authors: Morgan Kathleen M. , Brown Garry , Pichon Monique A. , Green Geannette Y. 
Published: February 2011

AbstractThe base‐induced rearrangement of aziridines has been examined using a combination of calculations and experiment. The calculations show that the substituent on nitrogen is a critical feature that greatly affects the favorability of both α‐deprotonation, and β‐elimination to form an allylic amine. Experiments were carried out to determine whether E2‐like rearrangement to the allylic amine with lithium diisopropyl amide (LDA) is possible. N‐tosyl aziridines were found to deprotonate on the tosyl group, preventing further reaction. A variety of N‐benzenesulfonyl aziridines having both α‐ and β‐protons decomposed when treated with LDA in either tetrahydrofuran or hexamethylphosphoramide. However, when α‐protons were not present, allylic amine was formed, presumably via β‐elimination. Copyright © 2011 John Wiley & Sons, Ltd.
IL‐10 inhibits inflammatory cytokines released by fetal mouse lung fibroblasts exposed to mechanical stretch
Authors: Hawwa Renda L. , Hokenson Michael A. , Wang Yulian , Huang Zheping , Sharma Surendra , Sanchez‐Esteban Juan 
Published: February 2011

AbstractBackgroundMechanical ventilation plays an important role in the pathogenesis of bronchopulmonary dysplasia. However, the molecular mechanisms by which excessive stretch induces lung inflammation are not well characterized.ObjectivesIn this study, we investigated in vitro the contribution of lung mesenchymal cells to the inflammatory response mediated by mechanical stretch and the potential protective role of IL‐10.MethodsFetal mouse lung fibroblasts isolated during the saccular stage of lung development were exposed to 20% cyclic stretch to simulate mechanical injury. The phenotype of cultured fibroblasts was investigated by red oil O and alpha‐smooth muscle actin (α‐SMA) staining. Cell necrosis, apoptosis, and inflammation were analyzed by lactate dehydrogenase release, cleaved caspase‐3 activation and release of cytokines and chemokines into the supernatant, respectively.ResultsFirst, we characterized the phenotype of the cultured fibroblasts and found an absence of red oil O staining and 100% positive staining for α‐SMA, indicating that cultured fibroblasts were myofibroblasts. Mechanical stretch increased necrosis and apoptosis by two‐ and three‐fold, compared to unstretched samples. Incubation of monolayers with IL‐10 prior to stretch did not affect necrosis but significantly decreased apoptosis. Mechanical stretch increased release of pro‐inflammatory cytokines and chemokines IL‐1β, MCP‐1, RANTES, IL‐6, KC and TNF‐α into the supernatant by 1.5‐ to 2.5‐fold, and administration of IL‐10 before stretch blocked that release.ConclusionsOur data demonstrate that lung interstitial cells may play a significant role in the inflammatory cascade triggered by mechanical stretch. IL‐10 protects fetal fibroblasts from injury secondary to stretch. Pediatr. Pulmonol. 2011; 46:640–649. © 2011 Wiley‐Liss, Inc.
Airway angiopoietin‐2 in ventilated very preterm infants: Association with prenatal factors and neonatal outcome
Authors: Thomas Wolfgang , Seidenspinner Silvia , Kramer Boris W. , Wirbelauer Johannes , Kawczyńska‐Leda Natalia , Szymankiewicz Marta , Speer Christian P. 
Published: February 2011

AbstractObjectivePulmonary angiogenesis is a prerequisite for lung development. Angiopoietin‐2 (Ang2) destabilizes endothelial cells through its endothelial receptor TIE‐2, enabling vascular sprouting. Ang1 stabilizes new blood vessels. Soluble TIE‐2 (sTIE‐2) modulates these effects. We hypothesized that histological funisitis is associated with alterations of Ang2 in airways and of the systemic angiopoietin‐TIE‐2 homeostasis in very low birth weight (VLBW) infants, contributing to pulmonary morbidity and mortality.MethodsWe measured Ang2 in tracheobronchial aspirate fluid (TAF) of 42 VLBW <30 weeks of gestation from day 1 through 15 and Ang1, Ang2, and sTIE‐2 in umbilical cord serum of 28 infants by enzyme‐linked immunosorbent assay. Histological examination distinguished three groups: funisitis, chorioamnionitis, and controls.ResultsFunisitis was associated with lower Ang2 values in TAF but not with changes of Ang1, Ang2, and sTIE‐2 in umbilical cord serum. Infants who developed bronchopulmonary dysplasia (BPD) or died had a persistently decreased ratio of previously measured Ang1 to Ang2 in TAF on days 1–5 and increased cord serum concentrations of sTIE‐2. Moderate BPD/death was associated with an increase of Ang2 in TAF on day 10 and decreased Ang1/Ang2 ratio from day 3–15. Small for gestational age (SGA) infants had increased Ang2 in TAF on day 1–7 and a lower Ang1/Ang2 ratio on days 5–7.ConclusionsThe predominance of Ang2 in airway fluid of infants with BPD/death and SGA infants suggests a link between disrupted placental and fetal pulmonary angiogenesis. Histological funisitis with reduced Ang2 in TAF was of minor relevance for outcome in our cohort. Pediatr. Pulmonol. 2011; 46:777–784. © 2011 Wiley‐Liss, Inc.
Repellency of a kaolin particle film to potato psyllid, Bactericera cockerelli (Hemiptera: Psyllidae), on tomato under laboratory and field conditions
Authors: Peng Linian , Trumble John T , Munyaneza Joseph E , Liu Tong‐Xian 
Published: February 2011

AbstractBACKGROUND: The potato psyllid, Bactericera cockerelli, is a vector of Candidatus Liberibacter solanacearum, causing several diseases in solanaceous crops. Laboratory and field no‐choice and choice experiments were conducted to evaluate the repellency of kaolin particle film on adults of B. cockerelli on tomato plants that had been sprayed with kaolin particle film on the upper surface only, on the lower surface only and on both leaf surfaces.RESULTS: In no‐choice tests in the laboratory, the numbers of adults on leaves were not different between the kaolin particle film and the water control, regardless of which leaf surface(s) were treated, but numbers of eggs were lower on the leaves treated with kaolin particle film than on those treated with water. In choice tests on plants treated with water/plants treated with kaolin particle film at ratios of 1:1, 6:3 or 8:1, fewer adults and eggs were found on the leaves treated with kaolin particle film than on leaves treated with water. Under field conditions, in caged no‐choice or choice tests, fewer adults, eggs and nymphs were found on plants treated with kaolin particle film than on plants treated with water. In an uncaged test under field conditions, plants sprayed with kaolin particle film had fewer psyllids than those sprayed with water.CONCLUSION: Even though potato psyllid adults could land on plants treated with kaolin particle film when no choice was given, fewer eggs were laid. When given a choice, the psyllids avoided plants treated with kaolin particle film under laboratory and field conditions. Kaolin particle film treatment may be a useful alternative for management of potato psyllids under field conditions. Copyright © 2011 Society of Chemical Industry
Alanine scanning analysis and structure–function relationships of the frog‐skin antimicrobial peptide temporin‐1Ta
Authors: Grieco Paolo , Luca Vincenzo , Auriemma Luigia , Carotenuto Alfonso , Saviello Maria Rosaria , Campiglia Pietro , Barra Donatella , Novellino Ettore , Mangoni Maria Luisa 
Published: February 2011

AbstractThe increasing resistance of bacteria and fungi to the available antibiotic/antimycotic drugs urges for a search for new anti‐infective compounds with new modes of action. In line of this, natural CAMPs represent promising and attractive candidates. Special attention has been devoted to frog‐skin temporins, because of their short size (10–14 residues long) and their unique features. In particular, temporin‐1Ta has the following properties: (i) it is mainly active on Gram‐positive bacteria; (ii) it can synergize, when combined with temporin‐1Tl, in inhibiting both gram‐negative bacterial growth and the toxic effect of LPS; (iii) it preserves biological activity in the presence of serum; and (iv) it is practically not hemolytic. Rational design of CAMPs represents a straightforward approach to obtain a peptide with a better therapeutic index. Here, we used alanine scanning analogs to elucidate the contribution of the side chains of each amino acid residue to the peptide's antimicrobial and hemolytic activity. Beside providing insight into the biophysical attributes and the critical positions within the peptide sequence, which govern the antimicrobial/hemolytic activity of this temporin isoform, our studies assist in optimizing the design of temporin‐based lead structures for the production of new anti‐infective agents. Copyright © 2011 European Peptide Society and John Wiley & Sons, Ltd.
Continuous wavelength modulation of semi‐polar plane InGaN/GaN MQWs based on vapor‐phase‐diffusion‐based selective‐area pyramidal growth
Authors: Fujiwara Tatsuki , Nakano Yoshiaki , Sugiyama Masakazu 
Published: February 2011

AbstractWe have achieved continuous wavelength modulation from InGaN quantum wells on semi‐polar {11–22} planes with selective‐area growth of hexagonal pyramids with varied widths of masks surrounding them. The thickness of InGaN wells on the surface of the pyramids was tailored by the mask width, which led to wavelength modulation. The use of semi‐polar planes reduced quantum confined stark effect, allowing a wider range of wavelength modulation: from 446 to 500 nm as measured by cathode luminescence.
Autowave of electron population depletion and sub terahertz self‐modulations of light absorption and intrinsic stimulated emission in GaAs
Authors: Ageeva N. N. , Bronevoi I. L. , Zabegaev D. N. , Krivonosov A. N. 
Published: February 2011

AbstractDuring picosecond photogeneration of electron‐hole plasma (EHP) in GaAs, intensive picosecond emission arises. Self‐modulations of light fundamental absorption and of emission characteristics are found out. These self‐modulations disclose origination in GaAs of wave of a new type, i.e., autowave of carrier populations depletion in energy space, a new type of collective excitation of carriers and a new form of EHP instability. (© 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Coherent control of electrical currents in semiconductor nanowires/‐tubes
Authors: Betz Markus , Ruppert Claudia , Thunich Sebastian , Newson Ryan , Ménard Jean‐Michel , Sames Christian , Abstreiter Gerhard , Fontcuberta i Morral Anna , Holleitner Alexander W. , van Driel Henry M. 
Published: February 2011

AbstractQuantum interference control of electrical currents is well established in bulk semiconductors. It arises from the interference of one‐ and two‐photon absorption pathways. Here, the concept is transferred to one‐dimensional semiconductor nanostructures. First, currents are optically injected into aligned single‐walled carbon nanotube ensembles by phase‐related 700 and 1400 nm, 150 fs pulses. These transient currents are detected via the emitted THz radiation. In a second set of experiments, a phase‐stable superposition of ∼100 fs pulses from a compact erbium‐doped fiber source and their second harmonic is shown to induce ultrashort ∼µA current bursts in single unbiased GaAs nanowires. The current flow is characterized by charge accumulation and the related potential difference between the contacted ends of the ∼10 µm long wires. (© 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Terahertz photoresponse dependence on magnetic and electric fields in graphene‐based devices
Authors: Salman M. , Gouider F. , Schmidt H. , Vasilyev Yu. B. , Haug R. J. , Nachtwei G. 
Published: February 2011

AbstractIn this study, the influence of a magnetic field on Landau levels (LLs) in graphene‐based devices is described via the magneto‐optical response induced by terahertz (THz) radiation. For single‐layer graphene, the resonance energies of the transitions between the LLs such as L1, L2 and L3, fit quite well to the terahertz spectral range.The scattering rate of the spectral lines of LLs is taken into account. Based on a theoretical analysis we argue that the fingerprints of the THz radiation in single‐layer graphene can be improved to be observed at low magnetic fields. (© 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)