bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prospective Validation of a Novel Strategy for Assessing Risk of Significant Hyperbilirubinemia
Authors: Gonçalves Américo , Costa Sandra , Lopes Andreia , Rocha Gustavo , Guedes Maria Beatriz , Centeno Maria José , Silva Jorge , Silva Maria Gorett , Severo Milton , Guimarães Hercília 
Published: December 2010

OBJECTIVE:Our aim was to validate a strategy for assessing the risk of significant hyperbilirubinemia in newborns with gestational ages of ≥35 weeks by combining predischarge bilirubin percentile data with gestational age data, for a European, predominantly white population.METHODS:We conducted a prospective cohort study with 463 newborns with gestational ages of ≥35 weeks who were admitted to the well-infant nursery. Total bilirubin levels were measured daily until discharge and once after discharge, between the third and eighth days of life, by using a Bilicheck device (Respironics, Murrysville, PA). The values obtained (&lt;52 hours) were plotted on an hour-specific bilirubin nomogram to determine the infant's bilirubin percentile, expressed as a risk zone. Patients were assigned to 1 of 3 risk groups (very low, low, or high) on the basis of a combination of risk zone and gestational age data and were monitored prospectively for the development of significant hyperbilirubinemia. The 95% confidence interval (CI) for the prevalence of significant hyperbilirubinemia was estimated with the binomial distribution method.RESULTS:Forty-four infants (11%) developed significant neonatal hyperbilirubinemia. The risks of developing significant hyperbilirubinemia were 1.3% (95% CI: 0.2%–3.7%) for the very low risk group (n = 230 [58.1%]), 3.4% (95% CI: 0.7%–9.8%) for the low risk group (n = 86 [21.7%]), and 47.50% (95% CI: 36.2%–59.0%) for the high risk group (n = 80 [20.20%]).CONCLUSIONS:The proposed strategy, based on predischarge bilirubin level and gestational age data, was a valid method for significant hyperbilirubinemia risk assessment in our population.
Predictors of Participant Dropout at Various Stages of a Pediatric Lifestyle Program
Authors: de Niet Judith , Timman Reinier , Jongejan Mieke , Passchier Jan , van den Akker Erica 
Published: December 2010

OBJECTIVE:
To evaluate baseline predictors of drop out at various stages in a lifestyle intervention for overweight and obese children.

PATIENTS AND METHODS:
Children and their families (N = 248) (aged 8–14 years) attended a lifestyle intervention. At baseline, we assessed anthropometric and demographic data, measured competence and behavioral problems, and family functioning. Dropout rates were analyzed at various stages in treatment with logistic regression analyses.

RESULTS:
Children who had mothers of non-white descent, who had higher BMI SDS, who participated in fewer activities, who did not have breakfast regularly, and who did not live in families with a static adaptability structure were more likely to drop out between 0 and 12 months. Different characteristics predicted dropout at various stages of treatment: (1) having an ethnic minority status and being older predicted dropping out between 0 and 3 months; (2) having a nonwhite mother, participating in fewer activities, having higher delinquency scores, and not presenting the family as extremely positive predicted dropping out between 3 and 9 months; and (3) having a higher BMI SDS, having fewer social problems, and not living in families with a static adaptability structure predicted dropping out between 9 and 12 months of treatment.

CONCLUSIONS:
The results indicate diffrerent characteristics predict dropping out from a pediatric lifestyle program at various stages in treatment. These findings highlight the need for tailored interventions that target different characteristics at various stages of treatment to reduce drop out rates.
Use of Quality-Improvement Methods to Improve Timeliness of Analgesic Delivery
Authors: Iyer Srikant B. , Schubert Charles J. , Schoettker Pamela J. , Reeves Scott D. 
Published: December 2010

OBJECTIVES:
Despite its high prevalence, pain often is poorly managed in the emergency department. We used improvement science and quality-improvement methods to reduce delays associated with opioid delivery for children presenting to the emergency department with clinically apparent extremity fractures.

METHODS:
On the basis of a review of the literature, interviews with key stakeholders, expert consensus, and reviews of isolated examples of patients receiving timely analgesics, a multidisciplinary improvement team identified a set of operational factors, or key drivers, believed to be critical to the performance of appropriate initial pain management for children presenting to the emergency department with acute extremity injury. These key drivers focused the development of an intervention.

RESULTS:
The intervention, termed the orthopedic evaluation process, addressed all 4 identified key drivers simultaneously by standardizing triage decisions, activating necessary health care providers, aligning the care delivery need with necessary resources, and allowing parallel-task completion between physicians and nursing staff. After implementation of this process, 95% of the patients with long-bone extremity fractures treated with intravenous opioids received a first dose within 45 minutes of arrival, compared with a preintervention baseline average of 20%.

CONCLUSIONS:
By applying quality-improvement and process improvement methodology, we identified key drivers for the rapid delivery of systemic opioids to patients with clinically apparent extremity fractures and significantly improved the timeliness of analgesic delivery for this subgroup of patients.
Gene Expression Dynamics During Bone Healing and Osseointegration
Authors: Lin Zhao , Rios Hector F. , Volk Sarah L. , Sugai James V. , Jin Qiming , Giannobile William V. 
Published: December 2010

Background:Understanding the molecular features of bone repair and osseointegration may aid in the development of therapeutics to improve implant outcomes. The purpose of this investigation is to determine the gene expression dynamics during alveolar bone repair and implant osseointegration.Methods:An implant osseointegration preclinical animal model was used whereby maxillary defects were created at the time of oral implant placement, while a tooth extraction socket healing model was established on the contralateral side of each animal. The surrounding tissues in the zone of the healing defects were harvested during regeneration for temporal evaluation using histology, immunohistochemistry, laser capture microdissection, and quantitative reverse transcription–polymerase chain reaction for the identification of a panel of 17 putative genes associated with wound repair.Results:In both models, three distinct expression patterns were displayed: 1) genes that are slowly increased during the healing process, such as bone morphogenetic protein 4, runt‐related transcription factor 2, and osteocalcin; 2) genes that are upregulated at the early stage of healing and then downregulated at later stages, such as interleukin and chemokine (C‐X‐C motif) ligands 2 and 5; and 3) genes that are constitutively expressed over time, such as scleraxis. Although some similarities between osseointegration and tooth extraction socket were seen, distinct features developed and triggered a characteristic coordinated expression and orchestration of transcription factors, growth factors, extracellular matrix molecules, and chemokines.Conclusions:Characterization of these events contributes to a better understanding of cooperative molecular dynamics in alveolar bone healing, and highlights potential pathways that could be further explored for the enhancement of osseous regenerative strategies.
Palper la cicatrice
Authors: Schneider Monique 
Published: December 2010

Résumé Une marque corporelle, une cicatrice au menton témoignant d’un accident d’enfance, fait l’objet d’allusions fractionnées dans le texte de Freud. Dans les rêves, la bouche risquant de perdre ses dents est attribuée à des personnages placés sous la responsabilité du rêveur, mais différents de lui : fils, patiente. Un passage textuel témoigne cependant d’une tentative d’appropriation de la cicatrice : la possibilité de la « palper ».
On the Reception and Production of Harmony. Some Points of Departure Based on the Škoromati
Authors: Fikfak Jurij 
Published: December 2010

Avtor razpravlja o dilemi, pred katero je (bil) postavljen pretekli in sodobni raziskovalec ljudskega življenja. Mnogi izvajalci ponujajo raziskovalcu harmonično, idealnotipsko podobo ritualne prakse, s katero želijo opozoriti na preteklo harmonijo. Na ta način se lahko raziskovalec ujame v podobe sveta, s katerimi izvajalec oblikuje vaško identiteto in s katerimi zamrzne čas; na drugi strani pa lahko raziskovalec odkrije kontekst neravnin, znotraj katerih poteka njegovo raziskovanje, kot samopredstavitev lokalne skupnosti in njenih najpomembnejših predstavnikov.
***
The author discusses a dilemma faced by previous and contemporary researchers of folk life. Many performers offer the researcher a harmonic, ideal-typical image of a ritual practice through which they wish to draw attention to former harmony. In this way the researcher can become wrapped up in images of the world through which the performers shape the identity of the village and can serve to freeze time – or the researcher may discover the contexts of the unevenness within which his or her research takes place as the self-presentation of a local community and its significant representatives.
β-Catenin Inhibits T Cell Activation by Selective Interference with Linker for Activation of T Cells–Phospholipase C-γ1 Phosphorylation
Authors: Driessens Gregory , Zheng Yan , Locke Frederick , Cannon Judy L. , Gounari Fotini , Gajewski Thomas F. 
Published: December 2010

AbstractDespite the defined function of the β-catenin pathway in thymocytes, its functional role in peripheral T cells is poorly understood. We report that in a mouse model, β-catenin protein is constitutively degraded in peripheral T cells. Introduction of stabilized β-catenin into primary T cells inhibited proliferation and cytokine secretion after TCR stimulation and blunted effector cell differentiation. Functional and biochemical studies revealed that β-catenin selectively inhibited linker for activation of T cells phosphorylation on tyrosine 136, which was associated with defective phospholipase C-γ1 phosphorylation and calcium signaling but normal ERK activation. Our findings indicate that β-catenin negatively regulates T cell activation by a previously undescribed mechanism and suggest that conditions under which β-catenin might be inducibly stabilized in vivo would be inhibitory for T cell-based immunity.
Alloimmune Response Results in Expansion of Autoreactive Donor CD4+ T Cells in Transplants That Can Mediate Chronic Graft-versus-Host Disease
Authors: Zhao Dongchang , Young James S. , Chen Yu-Hong , Shen Elizabeth , Yi Tangsheng , Todorov Ivan , Chu Peiguo G. , Forman Stephen J. , Zeng Defu 
Published: December 2010

AbstractChronic graft-versus-host disease (cGVHD) is considered an autoimmune-like disease mediated by donor CD4+ T cells, but the origin of the autoreactive T cells is still controversial. In this article, we report that the transplantation of DBA/2 donor spleen cells into thymectomized MHC-matched allogeneic BALB/c recipients induced autoimmune-like cGVHD, although not in control syngeneic DBA/2 recipients. The donor-type CD4+ T cells from the former but not the latter recipients induced autoimmune-like manifestations in secondary allogeneic BALB/c as well as syngeneic DBA/2 recipients. Transfer of donor-type CD4+ T cells from secondary DBA/2 recipients with disease into syngeneic donor-type or allogeneic host-type tertiary recipients propagated autoimmune-like manifestations in both. Furthermore, TCR spectratyping revealed that the clonal expansion of the autoreactive CD4+ T cells in cGVHD recipients was initiated by an alloimmune response. Finally, hybridoma CD4+ T clones derived from DBA/2 recipients with disease proliferated similarly in response to stimulation by syngeneic donor-type or allogeneic host-type dendritic cells. These results demonstrate that the autoimmune-like manifestations in cGVHD can be mediated by a population of donor CD4+ T cells in transplants that simultaneously recognize Ags presented by both donor and host APCs.
Guest‐Molecule‐Directed Assembly of Mesostructured Nanocomposite Polymer/Organoclay Hydrogels
Authors: Martin Jessica E. , Patil Avinash J. , Butler Michael F. , Mann Stephen 
Published: December 2010

AbstractGiven the urgent need for soft materials with high functional value, hydrogels based on the integrative assembly of organic polymers and nanoscale inorganic building blocks—so‐called nanocomposite polymer hydrogels—offer a generic approach to swollen hybrid networks with tuneable and synergistic properties. Here, we report a new approach to assembling nanocomposite polymer hydrogels with multiple levels of structural complexity and enhanced functionality by using nanoscale integration of mesostructured inorganic building blocks capable of sequestering and releasing drugs (ibuprofen, aspirin, naproxen) and enzymes (glucose oxidase). The viscoelastic materials are produced by noncovalent crosslinking of poly(vinylpyrrolidone) in the presence of low amounts (1–5 wt%) of an exfoliated synthetic organoclay that undergoes in situ guest‐molecule‐directed self‐assembly. The hydrogels can be moulded into shape‐persistent, free‐standing objects that are stable between pH values of 4 to 11 and self‐heal when damaged. Significantly, the mesostructured nanocomposite polymer hydrogels, which can be reversibly dried and reconstituted in the form of highly swollen materials, exhibit sustained drug release and can be recharged and reused. The results provide important guidelines for developing new multifunctional nanocomposite polymer hydrogels based on the concerted self‐assembly of inorganic building blocks with mesostructured interiors.
Equilibrium and absorption kinetics of carbon dioxide by solid supported amine sorbent
Authors: Monazam Esmail R. , Shadle Lawrence J. , Siriwardane Ranjani 
Published: December 2010

AbstractThe equilibrium and conversion‐time data on the absorption of carbon dioxide (CO2) with amine‐based solid sorbent were analyzed over the range of 303–373 K. Data on CO2 loading on amine based solid sorbent at these temperatures and CO2 partial pressure between 10 and 760 mm Hg obtained from volumetric adsorption apparatus were fitted to a simple equilibrium model to generate the different parameters (including equilibrium constant) in the model. Using these constants, a correlation was obtained to define equilibrium constant and maximum CO2 loading as a function of temperature. In this study, a shrinking core model (SCM) was applied to elucidate the relative importance of pore diffusion and surface chemical reaction in controlling the rate of reaction. Application of SCM to the data suggested a surface reaction‐controlled mechanism for the temperature of up to 40°C and pore‐diffusion mechanism at higher temperature. Published 2011 American Institute of Chemical Engineers AIChE J, 2011
Feasibility of the TNM‐based staging system of ocular adnexal extranodal marginal zone lymphoma of mucosa‐associated lymphoid tissue (MALT lymphoma)
Authors: Lee Sung‐Eun , Paik Ji‐Sun , Cho Won‐Kyung , Choi Byung‐Ock , Lee Sang‐Nam , Jung Seung‐Eun , Park Kyung‐Sin , Kang Chang‐Suk , Kim Sung‐Hoon , Yang Suk‐Woo , Cho Seok‐Goo 
Published: December 2010

AbstractThe American Joint Committee on Cancer has proposed the tumor, node, metastasis (TNM) staging system to overcome the limitations of the Ann Arbor staging system for ocular adnexal lymphoma. We performed this study to evaluate the feasibility of the TNM staging system for ocular adnexal extranodal marginal zone lymphoma of mucosa‐associated lymphoid tissue (OAML). The data form 66 total eyes from 54 patients with biopsy‐confirmed OAML according to World Health Organization classification were retrospectively analyzed. Using the TNM staging system, we reclassified all patients into two categories: (1) T1N0M0 stage group (n = 26), for patients with lymphoma involving only the conjunctiva; and (2) above T1N0M0 or bT1N0M0 stage group (n = 28), for patients with lymphoma extending to the orbit, eyelid, or adjacent structures, and/or bilateral OAML. After a 24‐month median follow‐up period for all patients, the T1N0M0 group revealed higher progression‐free survival (PFS) than the above T1N0M0 or the bT1N0M0 group (P = 0.041). In a separate analysis of only 50 patients categorized as Ann Arbor stage IE, the T1N0M0 group demonstrated higher PFS (100%) than the above T1N0M0 or the bT1N0M0 group (84.7%; P = 0.067). Our data show that the poor prognostic group classified as Ann Arbor stage IE can be further distinguished by using the TNM staging system. Thus, further studies to develop treatment strategies for reducing relapse after treatment for OAML should use the TNM staging system. Am. J. Hematol. 2011. © 2011 Wiley‐Liss, Inc.
Pain and death: Neurodegenerative disease mechanisms in the nociceptor
Authors: Reichling David B. , Levine Jon D. 
Published: December 2010

AbstractChronic peripheral neuropathic pain is the result of abnormal activity in sensory nerves. It is well recognized that this sensory nerve dysfunction can be caused by traumatic, toxic, or metabolic insult to the nerve. In addition, there is growing recognition that neuropathic pain is a frequent manifestation of neurodegenerative diseases. In this regard, important clues to the cellular mechanisms of neuropathic pain may be found by close examination of neurodegenerative diseases (including Parkinson's disease) in which neuropathic pain is often an underappreciated but important clinical manifestation. This approach identifies specific mitochondrial and cytoskeletal mechanisms, previously implicated in the pathophysiology of neurodegenerative diseases in the central nervous system, that might contribute to neuropathic dysfunction in peripheral sensory nerve fibers. Investigations in preclinical models of common peripheral neuropathic pain conditions have supported the idea that a subset of these cellular mechanisms of neurodegeneration can produce painful hyperactivity in primary afferent nociceptors. Importantly, this emerging concept of neurodegenerative disease mechanisms in the primary afferent nociceptor identifies novel molecular targets for the treatment neuropathic pain. Ann Neurol 2011;69:13–21
Antigen‐specific adaptive immune responses in fingolimod‐treated multiple sclerosis patients
Authors: Mehling Matthias , Hilbert Patricia , Fritz Stefanie , Durovic Bojana , Eichin Dominik , Gasser Olivier , Kuhle Jens , Klimkait Thomas , Lindberg Raija L.P. , Kappos Ludwig , Hess Christoph 
Published: December 2010

AbstractT cells exit secondary lymphoid organs along a sphingosine1‐phosphate (S1P) gradient and, accordingly, are reduced in blood upon fingolimod‐mediated S1P‐receptor (S1PR)‐blockade. Serving as a model of adaptive immunity, we characterized cellular and humoral immune responses to influenza vaccine in fingolimod‐treated patients with multiple sclerosis (MS) and in untreated healthy controls. Although the mode of action of fingolimod might predict reduced immunity, vaccine‐triggered T cells accumulated normally in blood despite efficient S1PR‐blockade. Concentrations of anti–influenza A/B immunoglobulin (Ig)M and IgG also increased similarly in both groups. These results indicate that fingolimod‐treated individuals can mount vaccine‐specific adaptive immune responses comparable to healthy controls. Ann Neurol 2011
An ontology‐based technique for preserving user preferences in document‐category evolutions
Authors: Lee Yen‐Hsien , Wei Chih‐Ping , Hu Paul Jen‐Hwa 
Published: December 2010

AbstractInfluxes of new documents over time necessitate reorganization of document categories that a user has created previously. As documents are available in increasing quantities and accelerating frequencies, the manual approach to reorganizing document categories becomes prohibitively tedious and ineffective, thus making a system‐oriented approach appealing. Previous research (Larsen & Aone, 1999; Pantel & Lin, 2002) largely has followed the category‐discovery approach, which groups documents by using a document‐clustering technique to partition a document corpus. This approach does not consider existing categories a user created previously, which in effect reflect his or her document‐grouping preference. A handful of studies (Wei, Hu, & Dong, 2002; Wei, Hu, & Lee, 2009) have taken a category‐evolution approach to develop lexicon‐based techniques for preserving user preference in document‐category reorganizations, but have serious limitations. Responding to the significance of document‐category reorganizations and addressing the fundamental problems of salient, lexicon‐based techniques, we develop an ontology‐based category evolution (ONCE), a technique that first enriches a concept hierarchy by incorporating important concept descriptors (jointly referred to as an ontology) and then employs the resulting enriched ontology to support category evolutions at a concept level rather than analyzing and comparing feature vectors at the lexicon level. We empirically evaluate our proposed technique and compare it with two benchmark techniques: CE2 (a lexicon‐based category‐evolution technique) and hierarchical agglomerative clustering (HAC; a conventional hierarchical document‐clustering technique). Overall, our results show that the ONCE technique is more effective than are CE2 and HAC, across all the scenarios studied. Furthermore, the completeness of a concept hierarchy has important impacts on the performance of the proposed technique. Our results have some important implications for further research.
Synthetic Studies toward Galbulimima Alkaloid (−)‐GB 13 and (+)‐GB 16 and (−)‐Himgaline
Authors: Zi Weiwei , Yu Shouyun , Ma Dawei 
Published: December 2010

AbstractCondensation of (S)‐3‐aminobutan‐1‐ol with 1,3‐cyclohexane‐dione followed by an intramolecular alkylation afforded bicyclic enamine 32, which was converted into enone 35 through a diastereoselective hydrogenation. Mukaiyama–Michael addition of a bicyclic silyl enol ether to 35 and subsequent stereochemistry inversion by means of an oxidation/reduction strategy provided lactone 41. After reduction of lactone 41 with LAH, Swern oxidation was carried out to give enone 46 upon a spontaneous intramolecular aldol reaction and cleavage of the ketal protecting group. SmI2‐mediated carbonyl–alkene reductive coupling of 46 proceeded smoothly in refluxing tetrahydrofuran to deliver pentacyclic intermediate 49, which was oxidized with 2‐iodoxybenzoic acid and then treated with trifluoroacetic acid to furnish (−)‐GB 13. The overall yield was 6.1 % over 19 linear steps. By following the known procedure, our synthetic (−)‐GB 13 was converted into himgaline. In addition, by starting from lactone 41, the first total synthesis of (+)‐GB 16, a newly isolated member of the gabulimima alkaloid family, was achieved. This synthesis features an intramolecular condensation between an amine and a 1,3‐diketone moiety.
The use of response cost to treat spitting by a child with autism
Authors: Bartlett Sara M. , Rapp John T. , Krueger Tyler K. , Henrickson Marissa L. 
Published: December 2010

AbstractWe evaluated the extent to which noncontingent access to one or multiple items and the contingent removal of a specific item decreased a young boy's spitting. Results indicated that the boy's spitting did not decrease when he was given noncontingent access to multiple, alternative stimuli or to a toy radio. By contrast, when the toy radio was removed contingent on spitting, the rate of the boy's spitting decreased to zero or near‐zero levels. Similar results were produced in the boy's special education classroom. Follow‐up sessions conducted 2 and 4 months later indicated that the reduction in the boy's spitting persisted across time. Copyright © 2010 John Wiley & Sons, Ltd.