bluuebunny/crossref_metadata_2025_split huggingface dataset:
НА ЧТО УКАЗЫВАЕТ ИСПРАВЛЕННЫЙ ТЕКСТ?
Authors: БУТАКОВ П.А. 
Published: February 2025

В сохранившихся манускриптах Первого послания Павла к Коринфянам слова Христа в стихе 11:24 встречаются в двух разных вариантах: в одном из них есть слова «приимите, ядите», а в другом их нет. Между этими двумя вариантами есть значительное смысловое различие. Расширенный вариант подчеркивает индивидуальный аспект Евхаристии, а краткий, напротив, институциональный. Существование этих двух вариантов может послужить важным свидетельством о динамике идейных трансформаций, происходивших в древней церкви. В зависимости от того, какой вариант считать исходным, а какой исправленным, история ранней церкви будет рассматриваться либо как процесс клерикализации, либо как индивидуализации.
Available manuscripts of Paul’s First Epistle to the Corinthians have a variant reading of Jesus’ words at the Last Supper in 11:24. The longer reading contains “take, eat” while the shorter reading does not. The two readings have a noticeable difference in meaning. The longer one highlights the individual value of the Eucharist; the shorter version, however, favors its institutional significance. The existence of both readings can be interpreted as a witness to an ideological dynamics in the early church. Depending on which of the two readings is considered prior, the church history would be seen either as an increase of clerical authority, or as an increase of value of the individual.
ВИТГЕНШТЕЙН И ПЛАТОН: ВОПРОС О ДИАЛОГЕ
Authors: РОДИН К.А. 
Published: February 2025

Антиплатонизм Витгенштейна в этике, философии религии и в философии математики хорошо известен. Однако подход Витгенштейна к текстам Платона и способ обращения Витгенштейна с некоторыми идеями Платона часто не обращают на себя должного внимания. В статье анализируются встречающиеся в текстах Витгенштейна ключевые цитаты и ссылки на Платона. Подробно рассматриваются соответствующие контексты цитирования. Доказывается, что единственный прямой интерес Витгенштейна к Платону касается диалоговой формы диалогов Платона и что природа языка или знания - как близкая по тематике составляющая платоновского дискурса - как таковая не интересовала Витгенштейна.
Wittgenstein’s Anti-Platonism in a field of ethics, philosophy of religion and philosophy of mathematics is a common place in Wittgenstein studies. But Wittgenstein’s approach to Plato and especially the way Wittgenstein reads Plato’s dialogues are usually dismissed. In the article, I recollect nearly all passages in Wittgenstein’s texts where Wittgenstein gives any quotations from Plato or any comments on Plato and Socrates. I analyze contexts in which these quotations and comments emerge. Then I argue that the only theme Wittgenstein was interested in Plato’s dialogues was the dialogical form itself and that the nature of language or the nature of knowledge (as a part of Platonistic discourse) appears to be of no interest for Wittgenstein.
"ЛЕКАРСТВО ДЛЯ ПРИПОМИНАНИЯ". ПЕРИПАТЕТИЧЕСКОЕ КОНСТРУИРОВАНИЕ ИНТЕЛЛЕКТУАЛЬНОЙ ИСТОРИИ ГРЕЦИИ. ДИКЕАРХ И ФИЛОСОФСКАЯ БИОГРАФИЯ
Authors: АФОНАСИН Е.В. 
Published: February 2025

Перипатетику Дикеарху принадлежала серия работ, посвященных интеллектуальной истории Греции, в том числе первый опыт того, что можно называть философской биографией. В качестве этапов развития философской мысли Дикеарх выделяет семерых мудрецов, Пифагора, Сократа и Платона, причем, каждый раз его интересует эволюция образа жизни философа от одиноких размышлений «мудрецов», через социальный морализм Пифагора и Сократа до «академической» жизни ученого. К сожалению, ни одно из сочинений Дикеарха не дошло до нас. Публикуемые свидетельства переводятся на основе нового издания фрагментов Дикеарха, сравнительно недавно опубликованного Mirhady (2001).
The Peripatetic Dicaearchus composed a series of works dedicated to the intellectual history of Greece. In a sense, he was the first ancient author to write a comprehensive history of philosophy, centered on such key figures, as the Seven Sages, Pythagoras, Socrates, and Plato. The sages are known for their highly practical maxims and general rules of right conduct; Pythagoras developed a new lifestyle and promulgated it in his public and private teaching; Socrates introduced a new form of intellectual and moral pursuit; while Plato founded an institutional framework for philosophical studies having thus paved the way to a systematic research, conducted by the Peripatetics. The evidences are translated on the basis of a new edition of Dicaearchus' fragments, prepared by Mirhady (2001).
APONTAMENTO DAS CONTRIBUIÇÕES ERGONÔMICAS PARA O AUMENTO DA QUALIDADE DE VIDA DOS TRABALHADORES
Authors: Lourenço Niza Iasmin , Leal Prachum Carla 
Published: February 2025

Este artigo tem por finalidade o apontamento de diversas aplicações ergonômicas que contribuem para o aumento da qualidade de vida dos trabalhadores. Foram realizadas comparações entre alguns estudos publicados em revistas e eventos (Encontro Nacional de Engenharia de Produção (ENEGEP), Simpósio de Engenharia de Produção (SIMPEP), Gestão & Produção, Revista Brasileira de Saúde Ocupacional (RBSO), Psicologia: Teoria e Pesquisa; e Floresta e Ambiente), desta maneira levantou-se diversos autores, as metodologias de pesquisa utilizadas, locais de estudo e trabalhadores analisados, o objeto de pesquisa (intuito) e suas aplicações (ferramentas utilizadas, questionários, pesquisa de satisfação entre outros). Assim foi possível entender as motivações da realização das pesquisas por esses autores, quais práticas são realizadas e as estratégias adotadas a fim de trazer um aumento no bem-estar, saúde e segurança estando aliadas a Qualidade de Vida nos ambientes de um posto de combustível, supermercado, setor público, no setor madeireiro, em uma indústria de biscoitos, comércio de pneus e por fim em mais 10 órgãos públicos federais. Foram abordados temas referentes à Ergonomia, Qualidade de Vida no Trabalho, Doenças Relacionadas ao Trabalho e Segurança do Trabalho. A pesquisa conta com uma abordagem qualitativa, os resultados foram obtidos por meio de uma Revisão narrativa, sendo possível verificar as diversas aplicações que a Ergonomia possui aliada a Qualidade de Vida, envolvendo aspectos físicos, psicológicos e organizacionais que impactam diretamente na saúde e segurança dos trabalhadores.
ANÁLISE DA PRODUÇÃO CIENTÍFICA BRASILEIRA SOBRE AGRICULTURA FAMILIAR E DESENVOLVIMENTO RURAL NO PERÍODO DE 2011 À 2020
Authors: Battisti Telles Leomara , Kuhn Gasparetto Brenda Gabriela , Bonfim João Augusto , De Souza Stunpf Jucilene 
Published: February 2025

O objetivo deste estudo é analisar, por meio de um framework teórico conceitual, a produção científica brasileira, disponível na base de dados Scielo.org, relacionada a agricultura familiar e desenvolvimento rural entre os anos de 2011 e 2020. Para a seleção e análise dos artigos foi utilizada a metodologia Methodi Ordinatio. A análise foi realizada considerando as seguintes variáveis: (a) o código do artigo; (b) periódico em que foi publicado; (c) ano de publicação; (d) título do artigo; (e) palavras-chave; (f) idioma; (g) autores; (h) estudos mais relevantes; (i) abordagem metodológica; (j) região onde o estudo foi desenvolvido; (k) linha de pesquisa. Os resultados mostraram que os periódicos nacionais que se destacam com maior número de publicações sobre o tema são a Revista de Economia e Sociologia Rural e a revista Interações. Percebeu-se que não existe uma tendência linear no número de publicações por ano e que a maioria dos artigos são estudos práticos, relacionados à linha de pesquisa Políticas Públicas e Governança. Adicionalmente, constatou-se que a maioria dos artigos são estudos práticos, que se concentram principalmente nas regiões Sul e Sudeste do país. A principal contribuição do presente estudo é que ele estabelece as bases para estudos futuros sobre o tema e revela importantes lacunas da literatura.
AVALIAÇÃO DAS PROPRIEDADES TERMOANÁLITICAS, MICROESTRUTURAIS E MECÂNICAS DOS FILMES PRODUZIDOS POR BASE DE MATRIZ SPI COM INCORPORAÇÃO DE POLISSACARÍDEOS
Authors: Picolloto Angela Maria , Filho Lucidio Molina , Amado Laíz Ravazzi , Bittencourt Paulo Rodrigo Stival , Silva Keila de Souza 
Published: February 2025

O presente trabalho teve como objetivo principal estudar, avaliar, e comparar, a estabilidade térmica das interações entre proteína de soja isolada com três polissacarídeos ajustados em pHs extremos 3 e 11. Resultados sugeriram que a interação de matrizes filmógenas SPI + alginato se mostrou mais termoresistente, com Tonset = 67,7. Tanto a DTG como a DSC foram sensíveis para identificação das temperaturas de maior cinética da desnaturação. A DSC explorou as temperaturas de agregação térmica superiores à 113,0 para as soluções na fase pós-desnaturação, com exceção na mistura SPI + pectina. Após a análise dos resultados termoanáliticos das soluções os filmes preparados foram ajustados em pH 11 e tratados nas temperaturas otimizadas características a partir dos resultados da DTG. Temperaturas de agregação térmica dos filmes foram identificadas nos perfis exotérmicos DSC dos filmes SPI, SPI + pectina, SPI + alginato e SPI + goma alfarroba sugerindo que com o aquecimento pós-desnaturação as ligações covalentes tendem a se formarem. No entanto, devido a pouca variação da entalpia envolvida nestes fenômenos, os resultados sugeriram fragilidade nas ligações químicas após a gelificacão das proteínas e misturas nos filmes. As micrografias obtidas indicam alterações morfológicas com a temperatura de tratamento térmico. Resultados das propriedades mecânicas demonstram atenuação da magnitude das propriedades mecânicas com o aquecimento
20D-Dynamic Representation of Protein Sequences Combined with K-means Clustering
Authors: Bielińska-Wąż Dorota , Wąż Piotr , Błaczkowska Agata 
Published: February 2025

Objective:
The objective of this research is to demonstrate that alignment-free bioinformatics
approaches are effective tools for analyzing the similarity and dissimilarity of protein
sequences. All numerical parameters representing sequences are expressed analytically, ensuring
precision, clarity, and efficient processing, even for large datasets and long sequences. Additionally,
a novel approach for identifying previously unknown virus strains is introduced.

Methods:
A novel approach is proposed, integrating the unique features of our newly developed
method, the 20D-Dynamic Representation of Protein Sequences, with the K-means clustering algorithm.
The sequences are represented as clouds of material points in a 20-dimensional space
(20D-dynamic graphs), with their spatial distribution being unique to each protein sequence. The
numerical parameters, referred to as descriptors in molecular similarity theory, represent quantities
characteristic of dynamic systems and serve as input data for the K-means clustering algorithm.

Results:
Examples of the application of the approach are presented, including projections of the
20D-dynamic graphs onto 3D spaces, which serve as a visual tool for comparing sequences. Additionally,
cluster plots for the analyzed sequences are provided using the proposed method.

Conclusion:
It has been demonstrated that the 20D-Dynamic Representation of Protein Sequences,
combined with the K-means clustering algorithm, successfully classifies subtypes of influenza
A virus strains.
Modeling the Physico-Chemical Characteristics of Benzenes through the Application of Zagreb Rho Indices
Authors: Çiftçi İdris 
Published: February 2025

Abstract:
The exploration of Quantitative Structure-Property Relationship (QSPR) frameworks
utilizes topological indices to clarify the chemical and physical attributes of molecular entities.
In the current investigation, we initially identified the rho degree of a vertex in conjunction with
the Zagreb rho indices associated with connected graphs, marking a notable progression within
the field of (chemical) graph theory. We demonstrate that there are correlations exceeding 0.94
between the Zagreb rho indices and the physicochemical properties of benzenes, which encompass
boiling point, pi-electron energy, molecular weight, polarization, molecular volume, and
relative formula mass. Our results reveal that the correlation coefficients between the Zagreb rho
indices and the established degree-based topological indices of benzenes exceed 0.93. Additionally,
we performed structural sensitivity and abruptness analyses of these novel indices and
compared them with alternative topological indices. The results and analyses provide evidence
that Zagreb rho indices are pertinent to QSPR research initiatives.
Targeted Management: Unlocking the Crucial Role of PROTACs in Cancer Treatment
Authors: Gupta Priyanka , Dutta Sumit , Kumar Prashant , Kaushik Monika , Ashique Sumel , Bhowmick Mithun 
Published: February 2025

Abstract:
Targeted Protein Degradation (TPD) offers a solution, eliminating disease-related proteins and overcoming challenges associated with unintended toxicity and lack of precision. PROTACs (Proteolysis Targeting Chimeras) represent an innovative strategy for the specific degradation of tar-get proteins through the UPS (Ubiquitin–Proteasome System). In comparison to conventional protein inhibitor medications, PROTAC offers advantages in terms of efficacy, selectivity, and the ability to overcome drug resistance in cancer treatment, contributing novel perspectives to the field of anti-cancer drug discovery. Proteins play vital roles in an organism’s health, and misfolded contributes to diseases like neurodegenerative disorders and cancer. Cells maintain protein balance through quality control systems, primarily the UPS and autophagy. Protac, a Targeted Protein Degradation (TPD) strategy, utilizes UPS, employing small molecules to induce targeted protein degradation. PROTAC exhibits promise in preclinical studies and clinical trials for diverse cancers. Notable examples in-clude breast cancer, where PROTAC targets CDK4/6 (cyclin-dependent kinase) and Estrogen Recep-tors (ER), prostate cancer, addressing Androgen Receptor (AR) degradation, hematologic malignan-cies, focusing on AURORA-A and CDKs, and NSCLC (Non-Small-Cell Lung Cancer), targeting Estimated Glomerular Filtration Rate (EGFR), and KRAS. Despite their potential, PROTAC faces challenges, including compensatory protein expression in response to targeted therapies. This com-prehensive review explores recent advancements in PROTAC and related technologies, emphasizing the mechanisms and structures of PROTAC and their applications in proteins targeting cancer.
Monitoring based on Risk Assessment Effects on Lung Cancer in Iran
Authors: Keramatinia Aliasghar , Mohseni Maryam , Davoudi-Monfared Esmat , Ghadyani Rezvaneh , Tavirani Mostafa Rezaei , Mozafari Javad Khaje , Masjedi Mohammad Reza , Movafagh Abolfazl 
Published: February 2025

Background:
Lung cancer (LC) is considered the leading type of cancer in the world. Similar
to other countries, smoking is known as the main reason for this disease. The present study aims
to assess the critical factors and risk assessment of LC in Iran.

Materials and Method:
Eligible studies were identified in Web of Science, Google Scholar, GLOBOCAN
data base, PubMed, Science Direct, Scopus, ScieLo, and HAL to find the relevant ones published
up to September 2024. Then, the relevant studies were analyzed using the keywords such as
“risk factor or lung cancer” and “lung cancers or lung tumor”. Finally, the supplementary studies
were addressed by the data provided by the Health Department at the Ministry of Health and Medical
Education of the Islamic Republic of Iran.

Results:
Smoking cigarette increases the cases which are at risk as secondhand smokers. The pattern
of smoking in Iran is increasing, especially among women at young ages. There is scattered and
vague information about gas, air pollution, nutrition and obesity, genetics, occupational exposure, and
lifestyle in LC.

Conclusion:
Smoking is regarded as the most vital risk factor for LC. However, other risk factors
exist, which should be considered in this disease. This study seeks to present the promise of prevention,
as well as providing suggestions to healthcare workers.

conclusion:
Although, the most important risk factor for lung cancer is smoking, there are other most risk factors effect that must be considered in lung cancer. It is obvious in this discussion here.
A Biochemical Investigation of the Prevalence of Hypercalcemia and
Thiazide-Related Hypercalcemia in Patients
Authors: Masoodi Shariq Rashid , Bhat Moomin Hussain , Najar Imtiyaz Ahmed , Khan Mosin S. , Bhat Javaid Rasool , Patyar Sazal , Arora Poonam , Kumar Manish 
Published: February 2025

Objective:
Hypercalcemia allied with thiazide diuretics is a widely acknowledged
clinical presentation. Hence, the purpose of this investigation was to ascertain the prevalence of
hypercalcemia and hypercalcemia linked to thiazides and to evaluate serum phosphorous, 25-
hydroxyvitamin D, and parathyroid hormone (PTH).

Methods:
This prospective, cross-sectional research study involved all patients, including
outpatients, and was conducted over a 12-month period. Between December 2017 and December
2018, an aggregate of 373 patients were enrolled. All patients with hypercalcemia (albumincorrected
serum calcium > 10.8 mg/dL) had their medical information put on a proforma,
together with the results of any tests (such as parathyroid hormone (PTH), 25-hydroxyvitamin D,
and serum phosphorus).

Results:
Out of 373 subjects, 7 (2%) were hypercalcemic. The mean corrected calcium levels in
the normo-calcemic group were 9.46 ± 0.60 mg/dL (95% CI, 9.4 – 9.5), and that in the hypercalcemic
group were 11.68 ± 0.82 mg/dL (95% CI, 10.9 – 12.4). Of the seven cases of hypercalcemia,
2 patients (28.6%) had thiazide-associated hypercalcemia (TAH) along with primary
hyperparathyroidism (PHPT). Of the remaining 5 hypercalcemia patients, two more had PHPT,
and one (14.3%) had hypervitaminosis D, whereas no cause was mentioned in the remaining 2
patients. Among the 4 PHPT patients, corrected calcium was slightly higher in those with TAH
vs those without TAH, though the difference was statistically insignificant (11.32 ± 0.43 vs 11.14
± 0.39 mg/dL; P > 0.7).

Conclusion:
TAH is the second primary cause of asymptomatic hypercalcemia after PHPT.
Thus, close coordination between the clinicians, pharmacology, pharmacovigilance, and the biochemistry
department may help in identifying these cases.
A Path to the Formation Mechanism of Propolis Nanoparticles, their Cytotoxicity on 3T3 Fibroblasts, Metastatic Murine B16F10 Cells, and their In vivo Irritability in Animals
Authors: González-Masís Jeimmy , Gonzalez-Paz Rodolfo J. , Ureña Yendry Regina Corrales , Guerrero Simón , González-Camacho Sara , Mora-Ugalde Nohelia , Baizán-Rojas Mónica , Loaiza Randall , Vega-Baudrit José Roberto , Cubero-Sesin Jorge M. 
Published: February 2025

Background:
Natural products, such as propolis, are an important source of biologically active compounds
with the potential to treat health disorders. Propolis is a well-known waxy resin recognized for its
antimicrobial, immunomodulatory, and cytotoxic effects.

Objective:
In this study, we aimed to clarify the formation mechanism of propolis nanoparticles from the perspective
of their stability and chemical composition. By evaluating the light absorption behaviour of the nanoparticles
formed in different media and quantifying the polyphenols, we show that they are superficially hydrophobic nanoparticles
with the capacity to encapsulate some polar compounds.

Methods:
Biological activity was evaluated by in vitro cell viability performed on NIH/3T3 fibroblasts incubated
with 10, 100, and 1000 μg/mL of propolis nanoparticles for 48 hours.

Results:
The results show that nanoparticles are cytocompatible, with a proliferation effect. In contrast, the results
of the viability of metastatic murine B16F10 cells indicate that a dose with a concentration of 5 μg/mL in the cell
culture media is sufficient to stop the abnormal cell growth, having an antitumor effect. This effect might be related
to the flavonoids present in the propolis nanoparticles. In vivo dermal irritability tests on New Zealand rabbits show
that propolis nanoparticles' aqueous dissolution was non-irritant.

Conclusion:
According to the results obtained from this study, reducing the size of raw propolis down to nanoparticles
and dispersing them in water solvents enhance its positive effects. The superficially hydrophobic propolis
nanoparticles encapsulate active compounds such as polyphenols and flavonoids, which also confirms their ability
to generate selective effects on the cells, depending on their nature.
Oxidative Stress in Cardiovascular Diseases: Mechanisms and Exploring Advanced Therapies
Authors: - Dushyant , - Balram , Singh Gurvirender , Kumar Nitish , Narwal Smita , Dhingra Ashwani K. 
Published: February 2025

Abstract:
The recognition of oxidative stress as a factor influencing the development and progression
of cardiovascular diseases (CVDs) is growing. By producing such reactive oxygen species
(ROS) in diverse areas within cells, including mitochondria and Nicotinamide Adenine Dinucleotide
Phosphate Hydrogen (NADPH)-oxidases, they end up causing damage through the
oxidation of lipids, proteins, and DNA. ROS indicates the beginning of inflammatory responses
and endothelial dysfunction, which are necessary to produce obstructions in blood vessels and
decreased blood vessel function. The fact that oxidative stress plays a significant role in CVD
development draws more attention to the need for novel therapies that aim to correct redox imbalances.
Therefore, natural polyphenols and antioxidants like vitamin C or E have shown their
efficacy in lowering levels of ROS and protecting against the damage caused by oxidative stress.
Anyone attempting to cure CVDs should focus on improving the safety and efficacy of antioxidant
treatments and identifying which patients will benefit from them the most. This paper discusses
not only advanced treatments but also the role played by oxidative stress in such CVD as
high blood pressure, hypercholesterolemia, and ischemic heart disease.
The Impact of Aquatic Programme Activities on the Quality of Life for People with Disabilities in the Western Cape, South Africa
Authors: Botha Johane , Connelly Hannah Kate , Haydricks Monique Rose , Johannes Malema Makhaya 
Published: February 2025

Introduction
Aquatic activities have been shown to enhance an individual's independence in functionality and contribute to an improved overall quality of life. The benefits that aquatic activities offer during rehabilitation or recreation have often been overlooked or underestimated for those with physical disabilities. Engaging in leisure, recreation, and physical activities, specifically water-based activities, can improve a person with disabilities’ body composition, mobility, and overall quality of life.

Aim of the Study
This study aimed to investigate the impact of aquatic program activities on the quality of life of people with disabilities in the Western Cape.

Methods
This study used quantitative research methods that used a cross-sectional design. A total of 39 participants over the age of 18 years who participated in aquatic activities completed the questionnaire on Google Forms. The researchers explained the study details to the participants and clarified any questions before administering the questionnaire. Descriptive statistics were used to report the data for an individual's quality of life.

Results
Results of this study report that individuals engaging in multiple aquatic activities or participating more frequently tended to have higher Quality of Life scores. The current study demonstrated that participation in aquatic activities enhances the individual's feelings of independence about their functionality. Aquatic activities offer numerous benefits that improve the overall well-being of the individual.

Conclusion
The results contribute to the growing understanding of the positive effects of aquatic interventions, advocating for their inclusion in rehabilitation, recreational, and wellness programmes for individuals with disabilities.