bluuebunny/crossref_metadata_2025_split huggingface dataset:
A comparison of development methods used to define portion sizes in food-based dietary guidelines around the world
Authors: Salesse Fanny , Eldridge Alison L. , Mak Tsz Ning , Gibney Eileen R. 
Published: February 2025

IntroductionFood-based dietary guidelines (FBDGs) are essential public health tools for delivering dietary recommendations, and generally include guidance on portion sizes. Despite existing guidelines on developing and implementing FBDGs, there is still no consensus on best practices for their formulation. This paper compares the methodologies used by public health organizations to create FBDGs and examines how both methodology and geographical location may influence recommended portion sizes.MethodsDocuments on FBDG development were obtained from the Food and Agriculture Organization online repository of FBDGs, either directly from consumer-facing FBDG or from corresponding scientific reports. Methodological details in FBDG development were extracted and categorized. Recommended portions in grams per day were extracted for 15 food categories to enable comparison across development methods and global regions.ResultsFBDGs from 96 countries were accessed and translated. Of these, n = 83 were based on consensus/review, n = 15 used data-based approaches, and n = 30 included other minor calculations. Thirty-nine FBDGs were derived from a combination of consensus/review and another method. Of the countries providing portion size information, only one did not report its methodological approach. Comparisons of median portions sizes of food groups across methodologies showed no significant differences. Analyses across regions revealed that portion recommendations were generally consistent, with significant differences found only for one food group, namely, Fish &amp; shellfish, where portion size recommendations were significantly higher in Europe compared to those in Latin America and the Caribbean.DiscussionResults indicate little variation in the recommendations for portion size across development methods, and for most food groups, across global regions. These findings suggest there is potential to harmonize portion size derivation in FBDGs at regional or global levels. However, further research is needed to assess whether harmonized guidance can apply to other aspects of FBDGs.
Enhanced antitumor activity of combined hepatic arterial infusion chemotherapy with Lenvatinib and PD-1 inhibitors in unresectable hepatocellular carcinoma: a meta-analysis
Authors: Zhao Lingling , Xu Cheng , Deng Jiewen , Ni Yang 
Published: February 2025

BackgroundHepatic arterial infusion chemotherapy (HAIC) is increasingly recognized as a primary treatment option for patients with unresectable hepatocellular carcinoma (uHCC), providing a focused treatment for localized tumors. The combination of lenvatinib, a multikinase inhibitor, with PD-1 inhibitors has demonstrated significant survival benefits in HCC. This meta-analysis aims to assess whether the integration of HAIC with lenvatinib and PD-1 inhibitors (referred to as the HAIC-L-P group) leads to better treatment effectiveness and security compared to lenvatinib and PD-1 inhibitors alone (L-P group) in uHCC.MethodsAn exhaustive search of the literature was conducted, including PubMed, the Cochrane Library, Embase, ClinicalTrials.gov, and Web of Science, from the start of each database until September 2024, to ensure a thorough and up-to-date compilation of relevant studies. Extract data on outcome measures such as overall survival (OS), progression-free survival (PFS), objective response rate (ORR), disease control rate (DCR), and adverse events (AEs). Subsequently, meta-analyses were performed using RevMan 5.4 to quantitatively evaluate the aggregated effect of the HAIC-L-P regimen versus the L-P regimen alone.ResultsIn our systematic meta-analysis of eight retrospective cohort studies, the HAIC-L-P regimen demonstrated markedly enhanced OS, with an HR of 0.54 (95% CI: 0.45-0.64; p &lt; 0.00001), and enhanced 1-year and 2-year OS rates. Superior PFS was also observed in the HAIC-L-P group, with an HR of 0.64 (95% CI: 0.55-0.75; p &lt; 0.0001), and higher 1-year and 2-year PFS rates. Response rates were markedly higher in the HAIC-L-P group, with an ORR risk ratio of 2.15 (95% CI: 1.84-2.50; p &lt; 0.00001) and a DCR risk ratio of 1.28 (95% CI: 1.20-1.43; p &lt; 0.0001). The AEs classified as grade 3 or above were elevated in the HAIC-L-P group, with notable risk ratios for vomiting, elevated AST, elevated ALT, thrombocytopenia, neutropenia, and hyperbilirubinemia. No life-threatening AEs were reported.ConclusionThe HAIC-L-P regimen correlated with enhanced tumor responses and prolonged survival, alongside manageable adverse effects, indicating its potential as a viable therapeutic strategy for individuals afflicted with uHCC.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42024594109.
Increase in methemoglobin fraction due to the use of glyceryl trinitrate patches in preterm infants: a case report and literature review
Authors: Calandrino Andrea , Vinci Francesco , Battaglini Marcella , Caruggi Samuele , Andreato Chiara , Montobbio Carolina , Vannati Marianna , Minghetti Diego , Brigati Giorgia , Ramenghi Luca Antonio 
Published: February 2025

BackgroundOxidized heme iron forms methemoglobin (MeHb), impairing the oxygen-binding capability of hemoglobin molecules. Nitric oxide (NO) obtained from glyceryl trinitrate (GTN) patches can cause MeHb formation during limb ischemia topical treatment. This case reports a preterm infant treated with multiple GTN patches who developed elevated MeHb levels, a potential therapy complication.Case presentationA preterm female newborn (25 + 4 weeks, 560 g) was delivered by cesarean due to maternal HELLP syndrome and intubated for respiratory distress. After developing ischemia in her right hand and foot, GTN patches were applied, but therapy caused a peak in methemoglobin (MeHb) levels, prompting patch removal. MeHb levels normalized after 18 h, and after adjusting therapy, ischemia resolved successfully.DiscussionWe report the case of a premature IUGR infant who developed elevated methaemoglobin (MeHb) levels during topical GTN therapy for catheter-related extremity ischemia. While GTN is effective for neonatal ischemia, its dosing, and safety lack consistent guidelines. Elevated MeHb levels, noted in similar cases here reviewed, can impair oxygen exchange, especially in vulnerable preterm infants with immature skin and reduced enzyme activity.ConclusionThis case highlights the need for careful MeHb monitoring and a multidisciplinary approach to manage ischemia safely in neonates undergoing GTN therapy.
Divergent thinking in groups during cold-water immersion is impaired by cold stress not the cold shock response
Authors: Smith Max Kailler , Weller Rebecca , Duong Tony , McClintock Rebecca , Peterson Matthew , Barr Nathaniel , Jones Douglas M. , Dunn Timothy L. 
Published: February 2025

IntroductionA primary hazard of working in cold maritime environments is the potential for a substantial man overboard situation in freezing waters. Sudden cold-water immersion (CWI) triggers the cold shock response (CSR), which consists of cardiorespiratory responses that increase the chance of drowning. If cold shock response severity can be mitigated, life-saving actions must be taken within the first 10 min, as after this time frame drowning occurs due to cold incapacitation. To date, research shows that executive functioning is generally impaired by intense, acute stress, which implies the ability to think through potential actions to maximize survival would also be impaired by the cold shock response.MethodsTo examine whether the severity of cold shock response impairs higher-level thinking in a group, 29 active duty service members completed a group format Divergent Association Task (DAT; 4–5 per group) prior to and during a 13-min cold-water immersion (water temperature: 1.3°C, air temperature: −2.7°C).ResultsResults showed no relationship between cold shock response magnitude, indexed by peak heart rate, and DAT performance. However, results indicated that those with lower skin temperatures performed worse on the DAT.DiscussionResults suggest that the ability to engage in divergent thinking is relatively preserved in the critical ~10-min window although skin cooling may bias attention toward the cold stress impacting task performance. Furthermore, subjective reports of the severity of the initial gasp tracked with peak heart rate demonstrating potential utility of subjective responses in the absence of respiratory measurements.
Men’s internet sex addiction predicts sexual objectification of women even after taking pornography consumption frequency into account
Authors: Novakova Pavla , Chvojka Edita , Ševčíková Anna , Blinka Lukas , Wright Paul , Kane Steven 
Published: February 2025

IntroductionProblematic online video pornography consumption is associated with sexual objectification, particularly in male consumers. However, previous studies have not considered that there is a subgroup of internet users whose consumption may become problematic due to their internet sex addiction. Such users may, in response to internet sex addiction symptoms such as craving, have increased levels of sexual objectification.MethodsIn a sample of 1,272 male consumers of online video pornography (Mage = 32.93, SDage = 9.44), we examined whether internet sex addiction is linked to sexual objectification via an online survey.ResultsWe fitted a series of structural equation models and found that men who scored higher on internet sex addiction were more likely to objectify women. More importantly, this link did not cease when controlling for the frequency of online video pornography consumption.DiscussionOur findings suggest that there are other mechanisms related to addictive symptomatology than just the link through online video pornography consumption that may contribute to sexual objectification. Addiction-related factors may have a unique role in fostering sexual objectification. Isolating internet sex addiction as a potential driver highlights the need to address objectifying behaviours in individuals struggling with this addiction.
Validating a digital depression prevention program for adolescents in Jordan: cultural adaptation and user testing in a randomized controlled trial
Authors: Dardas Latefa Ali , Al-leimon Obada , Gladstone Tracy , Dabbas Abd Arrahman , Alammouri Insaf , Van Voorhees Benjamin 
Published: February 2025

PurposeDigital health interventions (DHIs) offer scalable solutions for improving mental health care access in underserved settings. This study is part of a multi-phased project aimed at adapting a depression prevention DHI for Jordanian adolescents. It evaluated the feasibility, cultural acceptability, and effectiveness of the translated and culturally adapted DHI, named Al-Khaizuran, with comparisons to school-based group CBT.MethodsA two-arm, single-blind randomized controlled trial with a mixed-methods design was conducted among 109 Jordanian adolescents aged 15–17 years experiencing mild to moderate depression. Participants were randomly assigned to either Al-Khaizuran DHI (n=55) or school-based group CBT (n=54). The adaptation of Al-Khaizuran DHI components was guided by the Ecological Validity Framework, while the procedural adaptation followed Barrera and Castro’s Heuristic Framework, incorporating iterative refinement based on user feedback and contextual considerations.ResultsAl-Khaizuran DHI was found to be a culturally relevant and acceptable intervention for Jordanian adolescent. Over half of the participants reported that the intervention was effective, empowering, and easy to use, with 51% expressing satisfaction and willingness to recommend it. However, challenges such as limited access to personal devices, privacy concerns, and participants’ reliance on shared family resources emerged as significant barriers to consistent engagement. Participants showed a preference for individualized, blended interventions, with a significant reduction in support for group CBT. No significant difference was found in depression scores between the two groups. However, the Al-Khaizuran DHI group demonstrated higher post-intervention resilience scores (p=0.026). Beliefs about the effectiveness of the intervention significantly predicted behavioral intention (p=0.022), while perceived difficulty was a barrier to adherence (p=0.015).ConclusionsAl-Khaizuran DHI exemplifies the potential of culturally adapted digital interventions in bridging mental health care gaps in resource-limited settings. However, its effectiveness is contingent upon addressing barriers to access, enhancing program interactivity, and integrating hybrid support systems that combine digital tools with in-person guidance. Future implementations should consider strategies to actively engage parents to foster a supportive environment that promotes the well-being of adolescents.Clinical trial registrationhttps://doi.org/10.1186/ISRCTN14751844, identifier ISRCTN14751844.
Effects of family socioeconomic status on the self-expectations of children under grandparenting in China
Authors: Hu QiXuan 
Published: February 2025

IntroductionThe increasing expansion of grandparenting necessitates further study of the effects of grandparenting on child development. This study investigated the relationship between family socioeconomic status (SES) and children’s self-expectations in households involving grandparenting, using data from the “China Family Panel Studies” (CFPS). The CFPS is a national, large-scale, multidisciplinary social tracking survey conducted by the Institute of Social Science Survey (ISSS) at Peking University.MethodsThe analysis drew on data from 4,946 children aged 6-16 and their families, collected from CFPS2016 to CFPS2018. To determine whether grandparenting was involved, responses from the Children’s parents’ questionnaire were used. Any caregiving arrangement involving grandparents-whether during the day, at night, or both-was classified as grandparenting. Correlational and hierarchical regression analyses were conducted to examine the association between family SES and children’s self-expectations.ResultsThe findings revealed a significant negative correlation between family SES and children’s self-expectations, including its various dimensions, in both groups of families. Additionally, family SES was found to negatively predict children’s self-expectations. A potential explanation for this result is that children from low-income families may have a stronger desire to improve their environmental and social circumstances, fostering greater internal motivation and higher self-expectations. In comparison to families without grandparenting, those with grandparenting had significantly lower family SES, children’s self-expectations, parent-child communication, and parental marital status, with more students studying in non-elite schools. Parent-child communication and residential areas for children can positively predict children’s self-expectations in both groups of families.DiscussionThese findings highlight the significance of family SES and the influence of multiple factors for raising the self-expectations of children under grandparenting. Thus, to improve the quality of life for children under grandparent care and promote their physical and mental health requires a multi-level approach involving the state, society, and individuals within the family.
Utilization of preventative health checkup services in China among middle-aged and older adult population: evidence from China’s 28 provinces
Authors: Shen Jingyu , Fang Weiji , Zhu Yating , Ye Chunli , Zhu Yanhua , Tao Yanling 
Published: February 2025

IntroductionResearch on the utilization of outpatient and inpatient medical and health services for residents and the factors influencing them is well established, however, there are fewer relevant studies analyzing the utilization of preventive health check-up services for middle-aged and older adult people in China. In this study, we hope to understand the utilization of preventive health care services and identify the factors that influence such utilization, thereby providing insights for health policy and resource allocation.MethodsThe study uses data from the 2020 CHARLS survey, including 17,200 participants aged 45 and older.ResultsApproximately 47.3% of middle-aged and older adult individuals had at least one health checkup. Utilization was significantly influenced by age, area of residence, education level, social insurance, health insurance, personal income, presence of chronic diseases, and life satisfaction. Older adults, urban residents, and individuals with higher income or chronic conditions were more likely to utilize health checkup services.ConclusionThere are significant urban–rural disparities in the utilization of health checkup services among middle-aged and older adult people in China. Future health policies should prioritize rural areas and disadvantaged groups to improve equity and accessibility of health services.
Universal capillary screening for chronic autoimmune, metabolic and cardiovascular diseases: feasibility and acceptability of the UNISCREEN study
Authors: Angiulli Sara , Merolla Aurora , Borgonovo Elisa , De Lorenzo Rebecca , Spadoni Serena , Fontana Barbara , Manganaro Giuseppina , Rela Elena , Bongiovanni Alberto , Peracino Rita , Bellino Chiara , Pata Giulia , Bianconi Eleonora , Martinenghi Sabina , Ulivi Francesca , Renzi Cristina , Bosi Emanuele ,   UNISCREEN Study Group
Published: February 2025

BackgroundUNISCREEN is a general population study aiming at evaluating feasibility and acceptability of universal screening for chronic autoimmune (type 1 diabetes and celiac disease) and metabolic/cardiovascular diseases (dysglycemia, type 2 diabetes, dyslipidemia, hypertension) across all age groups using capillary blood sampling by fingerprick to measure disease risk markers.MethodsUNISCREEN was conducted in the Cantalupo fraction, Cerro Maggiore, Milan, Italy, counting 3,061 inhabitants between 1 and 100 years of age. Participation was voluntary, following a public call. Participants were invited to respond to feasibility and acceptability questionnaires immediately before and after the screening procedures, which included the following: capillary blood drawing for immediate measurement of metabolic parameters (glucose, glycated hemoglobin, total-, HDL- and calculated LDL-cholesterol, triglycerides) and late autoantibody assays; blood pressure measurement; brief consultation with a physician providing feed-back on immediate results and health recommendations. The study was registered as ClinicalTrials.gov NCT05841719.ResultsThe study included 1,535 participants (50.1% of local population). A single fingerprick was sufficient for all measurements in 47.1% of cases, while up to two were necessary in 86.9% of cases. Complete glucose and lipid panels were obtained in 1382 participants (90.0%). Sufficient serum for late autoantibody testing was obtained in 99.7% of participants. The questionnaires showed overall satisfaction, with over 90% of participants considering capillary sampling simple and practical, and preferring it to venous sampling. Before screening, 24.0% adults and 31.7% children’s parents were worried about the possibility of being diagnosed or identified as being at risk; worries decreased to 21.3 and 23.4%, respectively, after medical consultation. The immediacy of some result communication possibly contributed to reducing the anticipatory anxiety.ConclusionThe UNISCREEN study shows that universal screening for chronic autoimmune, metabolic and cardiovascular diseases in the general population using capillary blood testing is feasible and acceptable.
Evaluating ChatGPT-4's performance on oral and maxillofacial queries: Chain of Thought and standard method
Authors: Ji Kaiyuan , Wu Zhihan , Han Jing , Zhai Guangtao , Liu Jiannan 
Published: February 2025

ObjectivesOral and maxillofacial diseases affect approximately 3.5 billion people worldwide. With the continuous advancement of Artificial Intelligence technologies, particularly the application of generative pre-trained transformers like ChatGPT-4, there is potential to enhance public awareness of the prevention and early detection of these diseases. This study evaluated the performance of ChatGPT-4 in addressing oral and maxillofacial disease questions using standard approaches and the Chain of Thought (CoT) method, aiming to gain a deeper understanding of its capabilities, potential, and limitations.Materials and methodsThree experts, drawing from their extensive experience and the most common questions in clinical settings, selected 130 open-ended questions and 1,805 multiple-choice questions from the national dental licensing examination. These questions encompass 12 areas of oral and maxillofacial surgery, including Prosthodontics, Pediatric Dentistry, Maxillofacial Tumors and Salivary Gland Diseases, and maxillofacial Infections.ResultsUsing CoT approach, ChatGPT-4 exhibited marked enhancements in accuracy, structure, completeness, professionalism, and overall impression for open-ended questions, revealing statistically significant differences compared to its performance on general oral and maxillofacial inquiries. In the realm of multiple-choice questions, the application of CoT method boosted ChatGPT-4's accuracy across all major subjects, achieving an overall accuracy increase of 3.1%.ConclusionsWhen employing ChatGPT-4 to address questions in oral and maxillofacial surgery, incorporating CoT as a querying method can enhance its performance and help the public improve their understanding and awareness of such issues. However, it is not advisable to consider it a substitute for doctors.
Factors affecting the risk of gender-based violence among 2SLGBTQIA+ adolescents and youth: a scoping review of climate change-related vulnerabilities
Authors: Parzniewski Szymon , Luo Xing , Ru Siyu , Ozbilge Nevcihan , Breen Kyle , Wu Haorui 
Published: February 2025

Gender-based violence (GBV) is a pervasive and growing issue that affects diverse populations worldwide. This study aimed to synthesize the factors affecting the risk of GBV among 2SLGBTQIA+ adolescents and youth. A scoping review was conducted using international databases (Web of Science, Scopus, Proquest, PubMed, Embase, EBSCOhost) since 2009. The studies were independently appraised by two reviewers guided by the PRISMA approach. Ninety-nine articles focusing on the 2SLGBTQIA+ community, GBV, and adolescents or youth were included for the review. The factors affecting the risk of GBV among 2SLGBTQIA+ adolescents and youth were categorized into (1) Wellbeing and mental health; (2) Disparities compared to cisgender youth; (3) Perpetration and victimization; (4) Different types of violence; and (5) Differences among 2SLGBTQIA+ subgroups. The studies further showed relevance to climate-related stressors such as displacement and resource scarcity, and how those can further amplify the vulnerabilities of 2SLGBTQIA+ youth to GBV. The findings revealed the necessity for multi-level strategies that account for the compounded risks faced by 2SLGBTQIA+ adolescents and youth, including those introduced by environmental crises. These five factors related to GBV among 2SLGBTQIA+ adolescents and youth should be considered by social work professionals when working with at-risk populations. Due to limited robust evidence (from countries outside the US) and the diverse contexts of the selected studies, future research is needed to minimize GBV among 2SLGBTQIA+ adolescents and youth, especially as climate change introduces new layers of vulnerability.Systematic review registration10.37766/inplasy2024.4.0008