bluuebunny/crossref_metadata_2025_split huggingface dataset:
A real‐time signal processing software package for the electrophysiology laboratory
Authors: Tiver Kathryn D. , Strong Campbell , Dharmaprani Dhani , Chapman Darius , Jenkins Evan , Shahrbabaki Sobhan Salari , Ganesan Anand N. 
Published: April 2024

AbstractBackgroundReal‐time signal processing has to date been difficult to implement in the clinical electrophysiology laboratory. To date, no open access software solutions are available in electrophysiology (EP) laboratories to facilitate real‐time intraprocedural signal analysis. We aimed to develop an open access, scalable Python plug‐in to allow real‐time signal processing during human EP procedures.Methods and ResultsA Python‐based plug in for the widely available EnsiteX mapping system was developed. This plug‐in utilized the LiveSync feature of the system to allow real‐time signal analysis. An open access library was developed to allow end‐users to implement real‐time signal analysis using this platform, implemented in the Python programming language https://github.com/anand9176/WaveWatch5000Public.ConclusionWe have developed and demonstrated the feasibility of a readily scalable and open‐access Python‐based plug in to an electroanatomic mapping system (EnSiteX) to allow real‐time processing and display of electrogram (EGM) based information for the procedural electrophysiologist to view intraprocedurally in the electrophysiology laboratory. The availability, to the clinician, of traditional and novel EGM‐based metrics at the time of intervention, such as atrial fibrillation ablation, allows for key mechanistic insights into critical unresolved questions regarding arrhythmia mechanism.
Hidden in the depths, discovery of a new spiny sucker eel of the genus Lipogenys Goode and Bean 1895 (Teleostei, Notacanthiformes, Notacanthidae) in the eastern North Atlantic Ocean
Authors: Gomes Pedro , Silva Helena , Churro Catarina 
Published: April 2024

AbstractThis study describes Lipogenys hyalinumvelum, a new species of the genus Lipogenys found on the Portuguese coast on the northeastern Atlantic during a crustacean survey. Information on the classification history and known distribution of the genus Lipogenys is provided. Dichotomous keys to the genera of Notacanthidae and the species of Lipogenys, based on morphology, are provided. The specimens were analysed using both morphological and molecular methods, including DNA sequencing of the COI and 16S genes. The distinct genetic characteristics support the recognition of the present specimens as a new species. The hyaline color of the flap at the posterior edge of the operculum is a characteristic that differentiates L. hyalinumvelum from Lipogenys gillii and provides the etymology of the species name.
Black and Latiné parents' perspectives on supporting their children's emotional and physical health
Authors: Cooper Daniel K. , Alonzo Jayxa K. , Goldson Tracey , Jordan Isabel R. , Jatoi Fatima , Mallozzi Isabella , Lupini Francesca 
Published: April 2024

AbstractInformed by integrative models of cultural resilience, the purpose of this study was to (a) explore how parents are promoting their children's emotional and physical health, with a focus on race and ethnic‐racial socialization strategies, and (b) identify the barriers and challenges parents are experiencing in supporting their children's health. Ethnically racially matched qualitative interviews were conducted with 33 parents (82% women, 64% Black, 36% Latiné). Results of thematic analysis revealed three overarching themes: (a) Strategies for Promoting Children's Physical and Emotional Health, (b) Challenges Promoting Children's Physical and Emotional Health, and (c) Impact of Racism on Parenting and Children's Health. Most parents believed that racism had an impact on their parenting decisions and their children's health; however, there were some differences in ethnic–racial socialization practices between Black and Latiné parents. Findings have implications for culturally relevant parenting approaches to support children's emotional and physical health.
Validating the OCS‐Plus against a clinical standard: A brief report
Authors: Roberts Rebecca , Vohora Reena , Webb Sam S. , Demeyere Nele 
Published: April 2024

AbstractThis research aimed to determine the sensitivity and clinical validity of the OCS‐Plus, a stroke‐specific tablet‐based cognitive screening tool, in comparison with the MoCA, a routinely used screening tool, after stroke. Eighty‐six patients were recruited from Oxfordshire stroke wards over a 22‐month period and completed both screens. Overall, we found that the OCS‐Plus has good convergent validity and excellent sensitivity when compared with the MoCA. The OCS‐Plus is therefore of potential benefit to those seeking a sensitive screening tool.
Self‐crossing hyaluronic acid filler with combination use of polydioxanone thread in minipig model
Authors: Yi Kyu‐Ho , Kim Soo‐Bin , Hu Hyewon , Bae Hyungkyu , Park Hyun‐Jun , Yoon Jeung‐Hyun , Kim Hee‐Jin 
Published: April 2024

AbstractIntroductionThe advances of self‐crossing hyaluronic acid (SC‐HA) fillers combination use with polydioxanone thread in minipigs were examined for compatibility, effectiveness, and immune response.Materials and MethodsA 12‐week experiment was conducted using 6 minipigs (3 male and 3 female each) to evaluate the effects of SC‐HA filler. The molecular weight of SC‐HA filler was fixed at 200 kDa and alternative storage modulus of G80, G250, and G500 were examined. The procedure involved injecting SC‐HA filler and polydioxanone threads into the skin tissue of anesthetized minipigs, and tissue sampling after 1 month (three minipigs), and 3 months (three minipigs) for histological staining and analysis. The immune reaction was observed during the experiment.ResultsThe practitioner reported it was easy to inject the SC‐HA filler in combination with polydioxanone threads. All four storage modulus of SC‐HA fillers were injectable within the polydioxanone thread containing cannula. Also, during the procedure, there were no immune responses at the treated sites. The results of the histological tissue examination confirmed that there was no chemical interaction between SC‐HA filler and the existing polydioxanone thread, and it was observed that SC‐HA filler was more uniformly distributed within the tissue with lower storage modulus, resulting in a higher production of collagen in the surrounding filler. When combined with scaffold polydioxanone thread, the scaffold polydioxanone thread helped spread the filler evenly, resulting in a more evenly distributed collagen around the filler.ConclusionToday, the combination therapy of filler and polydioxanone thread in one procedure is challenging due to the high viscosity of conventional fillers. However, this study confirmed that combination therapy of filler and polydioxanone thread is possible with SC‐HA fillers. Additionally, it was found that polydioxanone thread does not seem to interfere with the crosslinking reaction of SC‐HA filler, and if used with a higher pH of polydioxanone, it may enhance the cross‐linking reaction and achieve a higher viscosity value. Finally, the study resulted in the idea of concrete as SC‐HA filler and reinforcing rod for polydioxanone thread.
Pareto‐efficient risk sharing in centralized insurance markets with application to flood risk
Authors: Boonen Tim J. , Chong Wing Fung , Ghossoub Mario 
Published: April 2024

AbstractCentralized insurance can be found in both the private and public sectors. This paper provides a microeconomic study of the risk‐sharing mechanisms in these markets, where multiple policyholders interact with a centralized monopolistic insurer. With minimal assumptions on the risk preferences of the market participants, we characterize Pareto optimality in terms of the agents' risk positions and their assessment of the likelihoods associated with their loss tail events. We relate Pareto efficiency in this market to a naturally associated cooperative game. Based on our theoretical results, we then consider a model of flood insurance coverage via an illustrative example. The lessons drawn from our theoretical results and this example lead to important policy implications for the existing National Flood Insurance Program in the United States.
Spectrum of sleep‐disordered breathing and quality of sleep in adolescent and adult patients with spinal muscular atrophy
Authors: Crescimanno Grazia , Lupica Antonino , Tommasello Vito , Di Stefano Vincenzo , Brighina Filippo , Marrone Oreste 
Published: April 2024

SummarySleep‐disordered breathing is common among children with spinal muscular atrophy, but has been hardly studied among adult subjects. Little is known about sleep quality in spinal muscular atrophy. The aims of this study were to evaluate occurrence and characteristics of sleep‐disordered breathing and subjective sleep quality among adolescent and adult patients with spinal muscular atrophy type 2 or 3. Twenty patients aged 33.9 ± 15.2 years were studied. They underwent nocturnal cardiorespiratory monitoring, lung and muscular function evaluation, and were administered the Pittsburgh Sleep Quality Index questionnaire. Nineteen patients showed sleep‐disordered breathing, with obstructive events in seven subjects and non‐obstructive events in the remaining 12. In the latter group, 10 patients showed pseudo‐obstructive hypopneas. Patients with non‐obstructive sleep‐disordered breathing were younger (p = 0.042), had a lower body mass index (p = 0.0001), were more often affected by spinal muscular atrophy type 2 (p = 0.001), and showed worse impairment of respiratory function than patients with obstructive sleep‐disordered breathing. Ten patients were classified as poor sleepers and 10 patients good sleepers. In the whole sample, sniff nasal inspiratory pressure proved to be the only independent predictor of sleep quality (p = 0.009). In conclusion, sleep‐disordered breathing is common even among adult patients with spinal muscular atrophy type 2 and 3, and may show either obstructive or different types on non‐obstructive features. A worse respiratory muscle function is associated to non‐obstructive sleep‐disordered breathing and poorer sleep quality. Sleep quality should receive greater attention especially in patients with spinal muscular atrophy type 2, who have a poorer respiratory muscle function, as it could affect their quality of life.
Pharmacokinetics and pharmacodynamics of dextroketamine alone or combined with midazolam in Caiman crocodilus
Authors: Hirano Líria Queiroz Luz , de Oliveira Adrielly Lorena Rodrigues , de Barros Rafael Ferraz , Veloso Danillo Fabrini Maciel Costa , Lima Eliana Martins , Santos André Luiz Quagliatto , Moreno Juan Carlos Duque 
Published: April 2024

AbstractPharmacokinetics studies of anesthetic agents are important for understanding of the pharmacology and metabolism of anesthetic agents in reptilians. This study was designed to examine the pharmacokinetic and pharmacodynamic properties of intravenous dextroketamine alone or combined with midazolam in Caiman crocodilus. Eight caimans were anesthetized with dextroketamine (10 mg/kg; group D) or dextroketamine and midazolam (10 and 0.5 mg/kg respectively; group DM) into the occipital venous sinus. The pharmacokinetic parameters were calculated by HPLC using a non‐compartmental modeling. Serial blood samples were collected at baseline and within 15 and 30 min, and 11.5, 2, 4, 8, 12, 24 and 48 h of drug administration. Sedation status over time differed between groups. All animals in group D (8/8; 100%) showed signs of light sedation at t10. Half (4/8; 50%) of these caimans did not progress to deeper levels of sedation. In spite of light sedation at t10, animals in group DM were deeply sedated within 13.13 ± 7.04 min of anesthetic agent injection. The area under the plasma concentration–time curve (AUC0–48) and half‐life of dextroketamine changed significantly after combination with midazolam. Even without significant changes in clearance, the almost two‐fold increase in the half‐life of dextroketamine suggests a slower rate of elimination.
Why there are no Frankfurt‐style omission cases
Authors: Metz Joseph 
Published: April 2024

AbstractFrankfurt‐style action cases have been immensely influential in the free will and moral responsibility literatures because they arguably show that an agent can be morally responsible for a behavior despite lacking the ability to do otherwise. However, even among the philosophers who accept Frankfurt‐style action cases, there remains significant disagreement about whether also to accept Frankfurt‐style omission cases – cases in which an agent omits to do something, is unable to do otherwise, and is allegedly morally responsible for that omission. Settling this debate about Frankfurt‐style omission cases is significant because the resolution entails an important fact about moral responsibility: whether there is there a moral asymmetry between actions and omissions with respect to the ability to do otherwise. My proposal is that both Frankfurt‐style action cases and omission cases involve the same type of causal structure: causal preemption. However, the preemptor and the preemptee differ. In action cases, the Frankfurted agent preempts the neuroscientist and is causally and morally responsibility for the effect. In omission cases, Frankfurted agent is neither causally nor morally responsible for the effect. Instead, the neuroscientist preempts the Frankfurted agent. Thus, there are no Frankfurt‐style omission cases.
Phenotypic selection patterns in a hybrid zone between two Calceolaria species with contrasting pollinators: insights from field surveys and fitness assessments
Authors: Estévez Manso Galán Lucía , Antonetti Marco , Ibañez Ana C. , Sérsic Alicia N. , Cocucci Andrea A. 
Published: April 2024

Summary

Hybrid zones provide natural experimental settings to test hypotheses about species divergence. We concentrated on a hybrid swarm in which oil‐collecting bees and flower‐pecking birds act as pollinators of two Calceolaria species. We asked whether both pollinators contributed to flower divergence by differentially promoting prezygotic fitness at the phenotypic extremes that represent parentals.

We studied pollinator‐mediated selection on phenotypic traits critical in plant–pollinator mechanical interaction, namely plant height, reward‐to‐stigma distance, and flower shape. We utilised the quantity and quality of pollen deposited as fitness measures and distinguished between the contribution of the two pollinator types.

Results showed uni‐ and bivariate disruptive selection for most traits through pollen grains deposited by both pollinators. Bird‐mediated fitness favoured low plants with a long reward‐to‐stigma distance and a straight corolla, while bee‐mediated fitness favoured tall plants with a short reward‐to‐stigma distance and curved corolla. In addition, stabilising selection at one end of the phenotypic range showed a bird‐mediated reproductive asymmetry within the swarm. The disruptive pattern was countered, albeit weakly, by hybrids receiving higher‐quality pollen on the stigmas.

Results suggest that pollinator‐mediated selection promotes divergence of integrated flower phenotypes mechanically adjusted either to bees or birds underscoring the importance of pollinator specialisation in diversification.
Gustatory dysfunction and long COVID in Chinese patients with COVID‐19: A 6‐month follow‐up study
Authors: Wei Jie , Lu Chenghui , Ding Yan , Lu Yongjian , Yang Xin , Zhang Xi , Tang Guoyao 
Published: April 2024

AbstractAimsTo evaluate long COVID of gustatory dysfunction and the associated risk factors regarding onset and recovery in Chinese patients.MethodsWe conducted a cross‐sectional study of patients with SARS‐CoV‐2 Omicron infection at Changxing Mobile Cabin Hospital in Shanghai, China, from March to May 2022. A prospective follow‐up of patients with gustatory dysfunction was conducted at 6 months after discharge.ResultsIn total, 18.48% (241/1304) reported gustatory dysfunction. The 6‐month follow‐up response rate was 89.63% (216/241) and 74.02% recovered their taste sense within 1–3 weeks. A total of 20.37% of patients (44/216) presented with long COVID. Symptoms persisted for 12 patients (5.56%) after 6 months. Having multiple taste impairments (OR, 2.364; 95% CI, 1.286–4.348; p = 0.006) was associated with a higher risk of gustatory dysfunction with long COVID. Having received a COVID‐19 vaccine booster was positively associated with taste sensation recovery (HR, 1.344; 95% CI, 1.012–1.785; p = 0.041).ConclusionsAbout 20.37% of patients with COVID‐19 might develop long COVID of gustatory dysfunction and 5.56% with persisting changes in their sense of taste. Most patients recovered taste sensations within 1–3 weeks after COVID‐19 symptom onset and receiving a booster shot of the COVID‐19 vaccine presented a protective effect on the taste sensation recovery.
Clinicopathological importance of Bcl‐2 and p53 in postmenopausal triple‐negative breast carcinoma and association with age
Authors: Ito Kei , Honma Naoko , Ogata Hideaki , Yamada Akimitsu , Miyashita Mika , Arai Tomio , Sasaki Eiichi , Shibuya Kazutoshi , Mikami Tetuo , Sawaki Masataka 
Published: April 2024

AbstractAppropriate biomarkers are required to predict the clinical outcome of triple‐negative breast cancer (TNBC). In this study, we focused on the clinical importance of two representative tumor‐associated proteins, Bcl‐2 and p53. Bcl‐2 expression is usually related to estrogen receptor expression and a favorable outcome in breast cancer. TNBC has been reported to show a high frequency of p53 positivity suggesting TP53 mutations. The expressions of Bcl‐2 and p53 were immunohistochemically examined in TNBC involving two age groups of postmenopausal women (≥75 y/o, n = 75; 55–64 y/o, n = 47), who underwent surgery without neoadjuvant therapy. We examined their associations with each other, or with clinicopathological factors including the outcome. Bcl‐2 expression was inversely correlated with androgen receptor, apocrine morphology, and p53 expressions, and was an independent predictor of a poor outcome in total or in younger women. p53 positivity was associated with a more favorable outcome than p53 negativity in the younger group. In combined analyzes, none of the twenty Bcl‐2‐negative/p53‐positive cases in the younger group exhibited recurrence, resulting in the independent favorable predictive value of Bcl‐2‐negative/p53‐positive. The anti‐apoptotic nature of Bcl‐2 may be apparent in TNBC. The excellent outcome of Bcl‐2‐negative/p53‐positive cases in the younger group warrants further combined investigation of Bcl‐2/p53 in TNBC.
Minimax estimation of functional principal components from noisy discretized functional data
Authors: Belhakem Ryad , Picard Franck , Rivoirard Vincent , Roche Angelina 
Published: April 2024

AbstractFunctional Principal Component Analysis is a reference method for dimension reduction of curve data. Its theoretical properties are now well understood in the simplified case where the sample curves are fully observed without noise. However, functional data are noisy and necessarily observed on a finite discretization grid. Common practice consists in smoothing the data and then to compute the functional estimates, but the impact of this denoising step on the procedure's statistical performance are rarely considered. Here we prove new convergence rates for functional principal component estimators. We introduce a double asymptotic framework: one corresponding to the sampling size and a second to the size of the grid. We prove that estimates based on projection onto histograms show optimal rates in a minimax sense. Theoretical results are illustrated on simulated data and the method is applied to the visualization of genomic data.
Eocene (48.7 Ma) eclogite at Chepelare, Central Rhodopes, Bulgaria: A key to the tectonics of the Rhodopes
Authors: Froitzheim Nikolaus , Fassmer Kathrin , Janák Marian , Georgiev Neven , Kurylo Sergii , Fonseca Raúl O. C. , Münker Carsten 
Published: April 2024

AbstractThe presence of an Eocene subduction event, in addition to Jurassic and Cretaceous ones, in the Rhodopes of Greece and Bulgaria is controversial. We report the first dating of an eclogite from the Lower Allochthon of the Rhodopes. The eclogite is a mafic lens enclosed in orthogneiss of the Arda‐2 Unit at Chepelare, Central Rhodopes. It was metamorphosed under conditions of ca. 25 kbar, 700–750°C. Garnet grains have outward‐increasing Mg contents and omphacite inclusions with the highest jadeite contents in their rims, indicating garnet growth under increasing pressure. Lu–Hf geochronology yielded an age of 48.7 ± 1.5 Ma. The age is linked to a late stage of garnet growth close to peak pressure, i.e. to subduction.
Wound-healing properties of Stryphnodendron adstringens (barbatimão) in skin and mucosa injuries: a scoping review protocol
Authors: Costa Drigo Rayane Teresa da Silva , Becker Adriana Caroci , Riesco Maria Luiza Gonzalez , Mascarenhas Victor Hugo Alves , Nick Jan M. 
Published: April 2024

Objective:
This review will map the literature on the types of research and methods used to investigate the wound-healing properties of Stryphnodendron adstringens (barbatimão) in skin and mucosa injuries.

Introduction:

Barbatimão is a Brazilian native plant and its wound-healing properties have been described in literature since the colonial period. It is one of the 71 plants included in the Brazilian health system’s national list of medicinal plants of interest. However, existing literature reviews on the subject are limited, not comprehensive, lack a search strategy, and lack peer review.

Inclusion criteria:
This scoping review will include all types of published and unpublished sources that investigate the wound-healing properties of barbatimão to treat any type of skin or mucosa injury in humans, animals, or in vitro, in any context.

Methods:
A scoping review will be conducted following JBI methodology. The main databases to be searched will include Embase (EBSCOhost), CINAHL (EBSCOhost), Scopus, PubMed (EBSCOhost), ScienceDirect, Lilacs, SciELO, CUIDEN, MOSAICO, Web of Science, Epistemonikos, and Google Scholar. Unpublished studies will also be considered. Two independent reviewers will examine titles and abstracts and select and read full-text sources for possible inclusion. Subsequently, the reviewers will extract and synthesize the data, which will be presented as a map, diagram, or table, according to the review objectives.

Review registration:
Open Science Framework osf.io/w57m4