bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors Associated with Potentially Preventable Hospitalization in Nursing Home Residents in New York State: A Survey of Directors of Nursing
Authors: Young Yuchi , Barhydt Nancy R. , Broderick Suzanne , Colello Anna D. , Hannan Edward L. 
Published: April 2010

OBJECTIVES: To describe characteristics of New York State nursing homes and identify factors associated with potentially preventable hospitalization in nursing home residents.DESIGN: Cross‐sectional survey.SETTING: Randomly selected nursing homes in New York State.PARTICIPANTS: One hundred forty‐seven directors of nursing (DONs).MEASUREMENTS: Data were collected using a Web‐based survey completed in January 2008. Variables included specific aspects of facility environment, nurse and aide services, resource availability, perceived determinants of hospitalization, and nursing home practice. Stepwise multivariate linear regression examined the associations between perceived determinants and potentially preventable hospitalization.RESULTS: Factors associated with potentially preventable hospitalization included presence of nursing staff trained to communicate effectively with physicians (P<.001); easy access to urgent laboratory results in less than 4 hours on weekends (P=.03); that physicians attempt to treat patients within the nursing home and admit to the hospital as a last resort (P<.001); higher reported proportion of residents enrolled in managed care plans for regular medical care (P=.04); higher perceived likelihood that illness will cause death (P=.03); perceived inadequate access by physicians to residents' and prior medical history, laboratory results, and electrocardiograms (ECGs) (P=.02), as reported by DONs.CONCLUSION: Efficient and effective care depends on continuity of communication between nurses and physicians and adequate access to patients' medical history, laboratory results, and ECGs. The following operational strategies may help institutions reduce potentially preventable hospitalizations: ensure effective communication between nursing staff and physicians regarding patients' condition; provide physicians with easy access to stat laboratory results in less than 4 hours on weekends and adequate access to the patient's medical history, laboratory results, and ECGs; and motivate physicians to treat residents within the nursing home whenever possible.
The Impact of Age on the Electroanatomical Characteristics and Outcome of Catheter Ablation in Patients with Atrial Fibrillation
Authors: TUAN TA‐CHUAN , CHANG SHIH‐LIN , TSAO HSUAN‐MING , TAI CHING‐TAI , LIN YENN‐JIANG , HU YU‐FENG , LO LI‐WEI , UDYAVAR AMEYA R. , CHANG CHIEN‐JONG , TSAI WEN‐CHIN , TANG WEI‐HUA , SUENARI KAZUYOSHI , HUANG SHIH‐YU , LEE PI‐CHANGE , CHEN SHIH‐ANN 
Published: April 2010

Age and Atrial Fibrillation.  Background: Previous studies have indicated that atrial fibrillation (AF) in patients over the age of 60 at diagnosis is a risk factor for a substantial increase in cardiovascular events. However, information about the impact of age on the atrial substrate and clinical outcome after catheter ablation of AF is limited. Methods: This study included 350 patients (53 ± 12 years, 254 males) who underwent circumferential pulmonary vein isolation (CPVI) of AF, guided by a NavX mapping system. The subjects were divided into three groups according to their age, as follows: Group I: age ≤50 (n = 141), Group II: age = 51–64 (n = 149) and Group III: age ≥65 years old (n = 60). The mean voltage and total activation time of the individual atria were obtained by using a NavX mapping system before ablation. Several parameters, including the gender, AF duration, and left atrial (LA) diameter were analyzed. Results: The younger age group had a significantly smaller LA diameter (Group I vs Group II vs Group III, 36.89 ± 7.11 vs 39.16 ± 5.65 vs 40.77 ± 4.95 mm, P = 0.002) and higher LA bipolar voltage (2.09 ± 0.83 vs 1.73 ± 0.73 vs 1.86 ± 0.67 mV, respectively, P = 0.024), compared with the older AF patients. The LA bipolar voltage exhibited a significant reduction when the patients became older, however, that did not occur in the right atrium. The incidence of an AF recurrence was higher in the older age group than in the younger age groups. A subgroup of patients with lone AF was analyzed and age was found to be an independent predictor of the AF recurrence after receiving the first CPVI in the multivariable model (P < 0.05). Conclusions: Age has a significant impact on the LA substrate properties and outcome of the catheter ablation of AF. (J Cardiovasc Electrophysiol, Vol. 21, pp. 966‐972, September 2010)
Do Beta‐Blockers Impact Microvolt T‐Wave Alternans Testing in Patients at Risk for Ventricular Arrhythmias? A Meta‐Analysis
Authors: CHAN PAUL S. , GOLD MICHAEL R. , NALLAMOTHU BRAHMAJEE K. 
Published: April 2010

Beta‐Blockers and Microvolt T‐Wave Alternans. Introduction: Results of microvolt T‐wave alternans (MTWA) studies vary and may be influenced by whether beta‐blocker therapy was withheld prior to MTWA assessment. We conducted a meta‐analysis of the predictive value of MTWA screening for ventricular arrhythmic events in primary prevention patients with left ventricular dysfunction and examined whether results differed depending upon whether beta‐blocker use was withheld prior to MTWA testing.
Methods and Results:
Prospective studies that evaluated whether MTWA predicted ventricular arrhythmic events published between January 1980 and September 2008 were identified. Summary estimates for the predictive value of MTWA were derived with random‐effects models. Nine studies involving 3,939 patients were identified. Overall, an abnormal MTWA (positive and indeterminate) test was associated with an almost 2‐fold increased risk for arrhythmic events (pooled RR = 1.95, 95% CI: 1.29–2.96; P = 0.002). However, significant heterogeneity across studies was observed (P = 0.024). In the 4 studies in which beta‐blocker therapy was not withheld prior to MTWA assessment, an abnormal MTWA test was associated with a 5‐fold increased risk for arrhythmic events (pooled RR = 5.39, 95% CI: 2.68–10.84; P < 0.001) and was robust to sensitivity analyses. In contrast, the association was much weaker in those studies where the use of beta‐blocker therapy was withheld prior to MTWA testing (pooled RR = 1.40, 95% CI: 1.06–1.84; P = 0.02).
Conclusions:
In primary prevention patients with left ventricular dysfunction, the predictive power of MTWA varied widely, based on whether beta‐blocker therapy was withheld prior to its assessment. This observation may explain the inconsistent results of MTWA studies in this population. (J Cardiovasc Electrophysiol, Vol. 21, pp. 1009‐1014, September 2010)
A Short‐Term, Randomized, Double‐Blind, Parallel‐Group Study to Evaluate the Efficacy and Safety of Dronedarone versus Amiodarone in Patients with Persistent Atrial Fibrillation: The DIONYSOS Study
Authors: LE HEUZEY JEAN‐YVES , DE FERRARI GAETANO M. , RADZIK DAVID , SANTINI MASSIMO , ZHU JUNREN , DAVY JEAN‐MARC 
Published: April 2010

Dronedarone versus Amiodarone in Patients with AF.  Introduction: We compared the efficacy and safety of amiodarone and dronedarone in patients with persistent atrial fibrillation (AF). Methods: Five hundred and four amiodarone‐naïve patients were randomized to receive dronedarone 400 mg bid (n = 249) or amiodarone 600 mg qd for 28 days then 200 mg qd (n = 255) for at least 6 months. Primary composite endpoint was recurrence of AF (including unsuccessful electrical cardioversion, no spontaneous conversion and no electrical cardioversion) or premature study discontinuation. Main safety endpoint (MSE) was occurrence of thyroid‐, hepatic‐, pulmonary‐, neurologic‐, skin‐, eye‐, or gastrointestinal‐specific events, or premature study drug discontinuation following an adverse event. Results: Median treatment duration was 7 months. The primary composite endpoint was 75.1 and 58.8% with dronedarone and amiodarone, respectively, at 12 months (hazard ratio [HR] 1.59; 95% confidence interval [CI] 1.28–1.98; P < 0.0001), mainly driven by AF recurrence with dronedarone compared with amiodarone (63.5 vs 42.0%). AF recurrence after successful cardioversion was 36.5 and 24.3% with dronedarone and amiodarone, respectively. Premature drug discontinuation tended to be less frequent with dronedarone (10.4 vs 13.3%). MSE was 39.3 and 44.5% with dronedarone and amiodarone, respectively, at 12 months (HR = 0.80; 95% CI 0.60–1.07; P = 0.129), and mainly driven by fewer thyroid, neurologic, skin, and ocular events in the dronedarone group. Conclusion: In this short‐term study, dronedarone was less effective than amiodarone in decreasing AF recurrence, but had a better safety profile, specifically with regard to thyroid and neurologic events and a lack of interaction with oral anticoagulants. (J Cardiovasc Electrophysiol, Vol. 21, pp. 597‐605, June 2010)
Plant quality effects on intraguild predation between Orius laevigatus and Aphidoletes aphidimyza
Authors: Hosseini Mojtaba , Ashouri Ahmad , Enkegaard Annie , Weisser Wolfgang W. , Goldansaz Seyed Hossein , Mahalati Mahdi Nassiri , Sarraf Moayeri Hamid Reza 
Published: April 2010

AbstractTo understand the influence of plant quality on intraguild predation and consequently on the suppression of a shared prey population as well as on plant yield, the interactions between Aphis gossypii Glover (Hemiptera: Aphididae) (shared prey), Aphidoletes aphidimyza (Rondani) (Diptera: Cecidomyiidae) (intermediate predator), and Orius laevigatus Fieber (Hemiptera: Anthocoridae) (top predator) were investigated in 25‐day experiments on cucumber, Cucumis sativus L. (Cucurbitaceae) at various N fertilization levels (90, 150, and 190 p.p.m.) in microcosm set‐ups under greenhouse conditions. The final aphid population size was significantly affected by an interactive effect of N fertilization and predator application. Regardless of the N fertilization levels, O. laevigatus alone was more effective in aphid suppression than A. aphidimyza alone. In addition, the risk for aphids of being predated upon by both predators together was significantly reduced in the low and medium‐N fertilization levels, whereas it was additive in the high‐N fertilization treatment. The A. aphidimyza population was suppressed by O. laevigatus in both the 90 and 150 p.p.m. N treatments. However, there was no intraguild predation of O. laevigatus on A. aphidimyza at the 190 p.p.m. N level. Total plant yield depended on predator treatments and N fertilization levels, with the highest yield produced at the 150 p.p.m. N fertilization level in treatments with either O. laevigatus alone or with both predators together. Our results demonstrate that the weak asymmetric intraguild predation among A. aphidimyza and O. laevigatus does not influence the ability of both predators together to diminish bottom‐up effects on aphid populations and the yield losses associated with aphid infestations.
Prefabricated zirconium dioxide implant abutments for single‐tooth replacement in the posterior region: evaluation of peri‐implant tissues and superstructures after 12 months of function
Authors: Nothdurft Frank , Pospiech Peter 
Published: April 2010

AbstractAim: In the present study, prefabricated abutments made of zirconium dioxide Y‐TZP (tetragonal zirconia polycrystals) were inserted into the posterior region under controlled clinical conditions. The aim was to test whether abutments made of zirconium dioxide are suitable for this indication. Investigation parameters included reactions of peri‐implant tissue and the structural integrity of the all‐ceramic superstructures on the implants. Results after 12 months in function are reported in this article.Material and methods: Forty implants of the XiVE® S plus screw‐type implants (DENTSPLY Friadent) were inserted into the posterior region of 24 patients. After the healing period, the implants were provided with all‐ceramic abutments made of zirconium dioxide Y‐TZP (FRIADENT® CERCON® Abutment; DENTSPLY Friadent). All‐ceramic crowns (CERCON® smart ceramics; DENTSPLY DeguDent) were used as superstructures and cemented using the conventional method. The following parameters were used to document the state of soft tissue: modified plaque index (mPI), sulcus fluid flow rate (SFFR, Periotron; Oraflow Inc), modified sulcus bleeding index (mSBI) and pocket depth (ST). Mesial and distal bone levels were determined on radiographs during the prosthetic treatment and at the 12‐month recall. The Periotest™ (Medizintechnik Gulden) was used to determine implant stability.Results: All implants could be followed up after 12 months in function. In the presence of good oral hygiene (mPI: 0.5), the parameters SFFR (18) and mSBI (0.5) were indicative of stable and healthy soft tissue. ST was highest at the distal points of measurement (2.3 mm) and was generally at a low level. Compared with the baseline situation, proximal bone defects were reduced from −1.1 to −1 mm during the 12‐month period of functioning. The mean Periost™ values at the 12‐month recall were −1.9 in the maxilla and −3.8 in the mandible. Neither implant loss nor crown fractures occurred. Chipping of parts of the veneering ceramic was registered in four cases (10%).Conclusion: After 12 months of wear, no mechanical failure was registered in any of the all‐ceramic abutments. On clinical investigation, the peri‐implant hard and soft tissues were largely healthy and devoid of inflammation. To cite this article:
Nothdurft F, Pospiech P. Prefabricated zirconium dioxide implant abutments for single‐tooth replacement in the posterior region: evaluation of peri‐implant tissues and superstructures after 12 months of function. Clin. Oral Impl. Res. 21, 2010; 857–865. doi: 10.1111/j.1600‐0501.2009.01899.x
The ROQUIN family of proteins localizes to stress granules via the ROQ domain and binds target mRNAs
Authors: Athanasopoulos Vicki , Barker Andrew , Yu Di , Tan Andy H‐M. , Srivastava Monika , Contreras Nelida , Wang Jianbin , Lam Kong‐Peng , Brown Simon H. J. , Goodnow Christopher C. , Dixon Nicholas E. , Leedman Peter J. , Saint Robert , Vinuesa Carola G. 
Published: April 2010

Roquin is an E3 ubiquitin ligase with a poorly understood but essential role in preventing T‐cell‐mediated autoimmune disease and in microRNA‐mediated repression of inducible costimulator (Icos) mRNA. Roquin and its mammalian paralogue membrane‐associated nucleic acid binding protein (MNAB) define a protein family distinguished by an ∼ 200 amino acid domain of unknown function, ROQ, that is highly conserved from mammals to invertebrates and is flanked by a RING‐1 zinc finger and a CCCH zinc finger. Here we show that human, Drosophila and Caenorhabditis elegans Roquin and human MNAB localize to the cytoplasm and upon stress are concentrated in stress granules, where stalled mRNA translation complexes are stored. The ROQ domain is necessary and sufficient for localization to arsenite‐induced stress granules and to induce these structures upon overexpression, and is required to trigger Icos mRNA decay. Gel‐shift, SPR and footprinting studies show that an N‐terminal fragment centred on the ROQ domain binds RNA from the Icos 3′‐untranslated region comprising the minimal sequence for Roquin‐mediated repression, adjacent to the miR‐101 sequence complementarity. These findings identify Roquin as an RNA‐binding protein and establish a specific function for the ROQ protein domain in mRNA homeostasis.Structured digital abstract
MINT‐7711163: TIA‐1 (uniprotkb:P31483) and Roquin (uniprotkb:Q4VGL6) colocalize (MI:0403) by fluorescence microscopy (MI:0416)
MINT‐7711475: RLE‐1 (uniprotkb:O45962) and TIA‐1 (uniprotkb:P31483) colocalize (MI:0403) by fluorescence microscopy (MI:0416)
MINT‐7711487: DmRoquin (uniprotkb:Q9VV48) and TIA‐1 (uniprotkb:P31483) colocalize (MI:0403) by fluorescence microscopy (MI:0416)
MINT‐7711447, MINT‐7711460: MNAB (uniprotkb:Q9HBD1) and TIA‐1 (uniprotkb:P31483) colocalize (MI:0403) by fluorescence microscopy (MI:0416)
MINT‐7711176: eIF3 (uniprotkb:P55884) and Roquin (uniprotkb:Q4VGL6) colocalize (MI:0403) by fluorescence microscopy (MI:0416)
MINT‐7711192: DCP1A (uniprotkb:Q9NPI6) and TIA‐1 (uniprotkb:P31483) colocalize (MI:0403) by fluorescence microscopy (MI:0416)
Disorders of Orgasm and Ejaculation in Men
Authors: Rowland David , McMahon Chris G. , Abdo Carmita , Chen Juza , Jannini Emmanuele , Waldinger Marcel D. , Ahn Tai Young 
Published: April 2010

ABSTRACTIntroductionEjaculatory/orgasmic disorders are common male sexual dysfunctions, and include premature ejaculation (PE), inhibited ejaculation, anejaculation, retrograde ejaculation, and anorgasmia.AimTo provide recommendations and guidelines concerning current state-of-the-art knowledge for management of ejaculation/orgasmic disorders in men.MethodsAn international consultation in collaboration with the major urology and sexual medicine associations assembled over 200 multidisciplinary experts from 60 countries into 25 committees. Committee members established specific objectives and scopes for various male and female sexual medicine topics. The recommendations concerning state-of-the-art knowledge of disorders of orgasm and ejaculation represent the opinion of seven experts from seven countries developed in a process over a 2-year period.Main Outcome MeasureExpert opinion was based on grading of evidence-based medical literature, widespread internal committee discussion, public presentation and debate.ResultsPremature ejaculation management is largely dependent upon etiology. Lifelong PE is best managed with PE pharmacotherapy (selective serotonin re-uptake inhibitor [SSRI] and/or topical anesthetics). The management of acquired PE is etiology specific and may include erectile dysfunction (ED) pharmacotherapy in men with comorbid ED. Behavioral therapy is indicated when psychogenic or relationship factors are present and is often best combined with PE pharmacotherapy in an integrated treatment program. Retrograde ejaculation is managed by education, patient reassurance, pharmacotherapy, or bladder neck reconstruction. Delayed ejaculation, anejaculation, and/or anorgasmia may have a biogenic and/or psychogenic atiology. Men with age-related penile hypoanesthesia should be educated, reassured, and instructed in revised sexual techniques which maximize arousal.ConclusionsAdditional research is required to further the understanding of the disorders of ejaculation and orgasm.
Erectile Function Rehabilitation in the Radical Prostatectomy Patient
Authors: Mulhall John P. , Bella Anthony J. , Briganti Alberto , McCullough Andrew , Brock Gerald 
Published: April 2010

ABSTRACT

Introduction
Prostate cancer is common and is being diagnosed in younger men now compared with two decades ago. Long-term functional outcomes are of significant importance to patient and impact upon the patient decision-making process regarding choice of therapy. Erectile function preservation (rehabilitation) has gained significant traction worldwide despite the absence of definitive evidence in its favor.

Aim
To define the role of rehabilitation in the prostate cancer patient who has undergone radical prostatectomy (RP).

Methods
A committee of five experts in the field from three countries was convened, and using a thorough analysis of the literature and the Delphi approach to expert opinion, recommendations were arrived at for clinicians treating men with prostate cancer before and after definitive surgical management.

Results
Recommendations arrived at included: that clinicians should discuss prevalence rates, the pathophysiology of erectile dysfunction after RP and the predictors of erectile function recovery, that validated instruments should be used using the published cut-offs for normalcy, that rehabilitation be discussed with patients, and that they be informed that significant potential benefits may be associated with rehabilitation.

Conclusions
The International Consensus of Sexual Medicine (ICSM) 2001 committee on rehabilitation after radical prostatectomy recommended that a discussion occur regarding rehabilitation in all patients undergoing or who have undergone RP. However, the committee recognized the absence of definitive data to date and could not comment on the optimal approach to rehabilitation at this time.
SDSS J150634.27+013331.6: the second compact elliptical galaxy in the NGC 5846 group
Authors: Chilingarian Igor V. , Bergond Gilles 
Published: April 2010

Abstract
We report the discovery of the second compact elliptical (cE) galaxy SDSS J150634.27+013331.6 in the nearby NGC 5846 group by the Virtual Observatory (VO) workflow. This object (MB=−15.98 mag, Re= 0.24 kpc) becomes the fifth cE where the spatially resolved kinematics and stellar populations can be obtained. We used archival HST WFPC2 images to demonstrate that its light profile has a two-component structure, and integrated photometry from GALEX, SDSS, UKIDSS and Spitzer to build the multiwavelength spectral energy distribution to constrain the star formation history (SFH). We observed this galaxy with the PMAS IFU spectrograph at the Calar-Alto 3.5-m telescope and obtained two-dimensional maps of its kinematics and stellar population properties using the full-spectral fitting technique. Its structural, dynamical and stellar population properties suggest that it had a massive progenitor heavily tidally stripped by NGC 5846.
A Blue Light‐inducible Phosphodiesterase Activity in the Cyanobacterium Synechococcus elongatus
Authors: Cao Zhen , Livoti Elsa , Losi Aba , Gärtner Wolfgang 
Published: April 2010

AbstractA blue light‐inducible phosphodiesterase (PDE) activity, specific for the hydrolysis of cyclic di‐GMP (c‐di‐GMP), has been identified in a recombinant protein from Synechococcus elongatus. Blue light (BL) activation is accomplished by a light, oxygen, voltage (LOV) domain, found in plant phototropins and bacterial BL photoreceptors. The genome of S. elongatus contains two genes coding for proteins with LOV domains fused to EAL domains (SL1 and SL2). In both cases, a GGDEF motif is placed in between the LOV and the EAL motifs. Such arrangement is frequently found with diguanylate‐cyclase (DGC) functions that form c‐di‐GMP. Cyclic di‐GMP acts as a second messenger molecule regulating biofilm formation in many microbial species. Both enzyme activities modulate the intracellular level of this second messenger, although in most proteins only one of the two enzyme functions is active. Both S. elongatus LOV‐GGDEF‐EAL proteins were expressed in full length or as truncated proteins. Only the SL2 protein, expressed as a LOV‐GGDEF‐EAL construct, showed an increase of PDE activity upon BL irradiation, demonstrating this activity for the first time in a LOV‐domain protein. Addition of GTP or c‐di‐GMP did not affect the observed enzymatic activity. In none of the full‐length or truncated proteins was a DGC activity detected.