bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Baltic Ice Lake in the southwestern Baltic: sequence‐, chrono‐ and biostratigraphy
Authors: JENSEN JØRN BO , BENNIKE OLE , WITKOWSKI ANDRZEJ , LEMKE WOLFRAM , KUIJPERS ANTOON 
Published: June 2010

Jensen, J. B., Bennike, O., Witkowski, A., Lemke, W. & Kuijpers, A. 1997 (September): The Baltic Ice Lake in the southwestern Baltic: sequence‐, chrono‐ and biostratigraphy. Boreas, Vol. 26, pp. 217–236. Oslo. ISSN 0300–9483.This multidisciplinary study focuses on late‐glacial deposits in the Mecklenburg Bay ‐Arkona Basin area. The sequence stratigraphical method has been used on shallow seismic and lithological data, in combination with biostratigraphical work and radiocarbon dating. Glacial‐till deposits underlie sediments from two Baltic Ice Lake phases. Varved clay deposits from the initial phase cover the deepest parts of the basins. A prograding delta is observed at the western margin of the Arkona Basin, prograding from the Darss Sill area. The delta system is possibly related to a highstand dated at 12.8 ka. A maximum transgression level around 20 m below present sea level (b.s.l.) is inferred, followed by a drop in water level and formation of lowstand features. The final ice lake phase is characterized by a new transgression. The transgression maximum as observed in the Mecklenburg Bay is represented by transgressive and highstand deltaic deposits. These also indicate a maximum shore level of 20 m b.s.l. The deltaic sediments that contain macroscopic plant remains and diatoms have yielded Younger Dryas ages. Mapping of the late‐glacial morphology of the Darss Sill area reveals a threshold at 23 to 24 m b.s.l. This means that the Baltic Ice Lake highstand phases inundated the Darss Sill, which implies that the westernmost extension of the Baltic Ice Lake reached as far as Kiel Bay. Forced regressive coastal deposits at the western margin of the Arkona Basin mark a lowstand level of around 40 m b.s.l. caused by the final drainage of the Baltic Ice Lake. The lowstand deposits predate lacustrine deposits from the Ancylus Lake, which date to approximately 9.6 ka BP.
Genetic Variation of the Ghrelin Signaling System in Females With Severe Alcohol Dependence
Authors: Landgren Sara , Jerlhag Elisabet , Hallman Jarmila , Oreland Lars , Lissner Lauren , Strandhagen Elisabeth , Thelle Dag S. , Zetterberg Henrik , Blennow Kaj , Engel Jörgen A. 
Published: June 2010

Introduction:  Central ghrelin signaling is required for the rewarding effects of alcohol in mice. Because ghrelin is implied in other addictive behaviors such as eating disorders and smoking, and because there is co‐morbidity between these disorders and alcohol dependence, the ghrelin signaling system could be involved in mediating reward in general. Furthermore, in humans, single nucleotide polymorphisms (SNPs) and haplotypes of the pro‐ghrelin gene (GHRL) and the ghrelin receptor gene (GHSR) have previously been associated with increased alcohol consumption and increased body weight. Known gender differences in plasma ghrelin levels prompted us to investigate genetic variation of the ghrelin signaling system in females with severe alcohol dependence (n = 113) and in a selected control sample of female low‐consumers of alcohol from a large cohort study in southwest Sweden (n = 212).Methods:  Six tag SNPs in the GHRL (rs696217, rs3491141, rs4684677, rs35680, rs42451, and rs26802) and four tag SNPs in the GHSR (rs495225, rs2232165, rs572169, and rs2948694) were genotyped in all individuals.Results:  We found that one GHRL haplotype was associated with reports of paternal alcohol dependence as well as with reports of withdrawal symptoms in the female alcohol‐dependent group. Associations with 2 GHSR haplotypes and smoking were also shown. One of these haplotypes was also negatively associated with BMI in controls, while another haplotype was associated with having the early‐onset, more heredity‐driven, type 2 form of alcohol dependence in the patient group.Conclusion:  Taken together, the genes encoding the ghrelin signaling system cannot be regarded as major susceptibility genes for female alcohol dependence, but is, however, involved in paternal heritability and may affect other reward‐ and energy‐related factors such as smoking and BMI.
Defective Translocation of PKCε in EtOH‐Induced Inhibition of Mg2+ Accumulation in Rat Hepatocytes
Authors: Torres Lisa M. , Konopnika Bocena , Berti‐Mattera Liliana N. , Liedtke Carole , Romani Andrea 
Published: June 2010

Background:  Rats chronically fed ethanol for 3 weeks presented a marked decreased in total hepatic Mg2+ content and required approximately 12 days to restore Mg2+ homeostasis upon ethanol withdrawal. This study was aimed at investigating the mechanisms responsible for the EtOH‐induced delay.Methods:  Hepatocytes from rats fed ethanol for 3 weeks (Lieber‐De Carli diet—chronic model), rats re‐fed a control diet for varying periods of time following ethanol withdrawal, and age‐matched control rats fed a liquid or a pellet diet were used. As acute models, hepatocytes from control animals or HepG2 cells were exposed to varying doses of ethanol in vitro for 8 minutes.Results:  Hepatocytes from ethanol‐fed rats presented a marked inhibition of Mg2+ accumulation and a defective translocation of PKCε to the cell membrane. Upon ethanol withdrawal, 12 days were necessary for PKCε translocation and Mg2+ accumulation to return to normal levels. Exposure of control hepatocytes or HepG2 cells to a dose of ethanol as low as 0.01% for 8 minutes was already sufficient to inhibit Mg2+ accumulation and PKCε translocation for more than 60 minutes. Also in this model, recovery of Mg2+ accumulation was associated with restoration of PKCε translocation. The use of specific antisense in HepG2 cells confirmed the involvement of PKCε in modulating Mg2+ accumulation.Conclusions:  Translocation of PKCε isoform to the hepatocyte membrane is essential for Mg2+ accumulation to occur. Both acute and chronic ethanol administrations inhibit Mg2+ accumulation by specifically altering PKCε translocation to the cell membrane.
Incidence and Electrophysiologic Properties of Dissociated Pulmonary Vein Activity Following Pulmonary Vein Isolation During Catheter Ablation of Atrial Fibrillation
Authors: KABRA RAJESH , HEIST E. KEVIN , BARRETT CONOR D. , DONALDSON DAVID , BLENDEA DAN , BEINART ROY , KORUTH JACOB , SINGH SHELDON , RUSKIN JEREMY , MANSOUR MOUSSA 
Published: June 2010

Dissociated PV Activity During AF Ablation. Introduction: Pulmonary veins (PV) play an important role in the arrhythmogenesis of atrial fibrillation (AF). Catheter‐based PV isolation is one of the primary treatments for symptomatic drug refractory AF. Following electrical isolation, isolated rhythms in the PV are encountered. The aim of this study was to assess the frequency of postisolation PV activity and classify the different rhythms observed. Methods and Results: This single center prospective study sought to assess the dissociated activity in the PVs following their isolation during AF ablation. In 100 consecutive patients (60 paroxysmal, 40 persistent) undergoing AF ablation, dissociated PV activity was recorded using a multielectrode mapping catheter following antral PV isolation. The dissociated PV activity was classified as (1) silent, (2) isolated ectopic beats, (3) ectopic rhythm, and (4) PV fibrillation. All the PVs were successfully isolated in all the patients. In 91 of 100 patients, there was dissociated activity in at least 1 isolated ipsilateral PV group. There was no significant difference in spontaneous PV activity between patients with paroxysmal and persistent AF (91.7% vs 90%, P = 1.0). Among the 200 isolated ipsilateral PV groups, 64 of 200 (32%) were silent, 86 of 200 (43%) demonstrated isolated ectopic beats, 41 of 200 (20.5%) had ectopic rhythms and 9 of 200 (4.5%) had PV fibrillation. The average cycle length of the PV ectopic rhythm was 2594 ± 966 ms (range 1193–4750 ms). Conclusions: Following PV isolation, a majority of patients demonstrate dissociated activity in at least 1 PV. This finding was evident in patients with both paroxysmal and persistent AF. (J Cardiovasc Electrophysiol, Vol. 21, pp. 1338‐1343, December 2010)
The Social Capital of Global Ties in Science: The Added Value of International Collaboration
Authors: Melkers Julia , Kiopa Agrita 
Published: June 2010

AbstractThe globalization of science is demonstrated in the mobility of scientists across national boundaries, the composition of the U.S. scientific workforce, and increased collaboration across national boundaries. While studies based on bibliometric and other data have been useful in identifying trends, collaborative clusters, and other patterns in international collaboration, they do not reveal the social dynamics behind those collaborations. This paper addresses the human and social capital factors that explain whether or not an academic researcher in science and engineering has an international collaborator. Further, through detailed statistical models, the analysis also addresses the factors that differentiate the specific resources derived from those international ties. Results show that non‐U.S. citizens are more likely to have close international collaborators, but that a range of factors explain this relationship. Further, results show that U.S. academic faculty mobilize different collaborative resources from international collaborators, versus their domestic collaborators.
International Co‐Authorship and Research Team Performance in Colombia
Authors: Ordóñez‐Matamoros Hector Gonzalo , Cozzens Susan E. , Garcia Margarita 
Published: June 2010

AbstractThis article examines the ways in which International Scientific Collaboration, as observed by the co‐authorship of journal articles written by local scientists and partners located overseas, affects the ability of research teams to produce bibliographic outputs and to contribute to local knowledge. A sample of 672 teams was randomly selected for the analyses. In addition, 20 interviews with experts and team members were administered to discuss models and results. Results show that co‐authoring with partners located overseas increases team output by nearly 40% and by between three and five bibliographic products. It also shows that a team's odds of involving Colombia in its research process are 2.2 times larger for those co‐authoring with a partner located overseas than for those that do not. Theoretical and policy implications are discussed.
Sarcomatoid renal cell carcinoma presenting in the oropharynx
Authors: Gammon Bryan Leigh , Gleason Briana C. , Thomas Antoinette B. , Cibull Thomas Lee 
Published: June 2010

Metastasis stemming from a distant malignancy is far less common than an oropharyngeal primary and represents only 1% of all oral neoplasms. The difficulty in diagnosing a metastasis in the oropharynx may be compounded if the lesion is poorly differentiated and bears little resemblance to the primary tumor. We present the case of synchronous metastatic renal cell carcinoma of the mandibular gingiva in a woman with sarcomatoid clear cell renal cell carcinoma. The metastatic lesion was poorly differentiated and lacked expression of the renal cell carcinoma (RCC) antigen. In contrast, PAX‐8 staining was strongly positive. This case serves to highlight the diagnostic difficulty posed by poorly differentiated lesions in the oropharynx and reinforces the sensitivity of the cell lineage‐specific transcription factor PAX‐8 in poorly differentiated RCC.Gammon BL, Gleason BC, Thomas AB, Cibull TL. Sarcomatoid renal cell carcinoma presenting in oropharynx.
Psoriatic arthritis: a review
Authors: Amherd‐Hoekstra Anne , Näher Helmut , Lorenz Hanns‐Martin , Enk Alexander H. 
Published: June 2010

SummaryPsoriatic arthritis (PsA) is an immunologically triggered, chronic inflammatory arthropathy, which can have a lasting influence on the quality of life of affected individuals. An early diagnosis is essential in order to institute adequate therapy. Both dermatologists and rheumatologists should be involved in the diagnosis and management of the disorder.Mild forms can be managed with NSAID and systemic corticosteroids. In acute forms with a confirmed diagnosis and oligo‐ to polyarticular involvement, disease‐modifying therapy with DMARD (Disease‐Modifying Antirheumatic Drugs) is indicated. New studies of PsA show that tumor necrosis factor (TNF) plays a central role in mediating inflammation. For this reason, TNF‐α antagonists have become more and more important as a second‐line therapy for PsA.
Secular trends of sports participation, sedentary activity and physical self‐perceptions in Hong Kong adolescents, 1995–2000
Authors: Mak Kwok‐Kei , Day Jeffrey R 
Published: June 2010

AbstractAim:  To assess the 5‐year secular changes in sports participation, sedentary activity, and physical self‐perceptions among Hong Kong adolescents.Methods:  A total of 2932 and 5692 secondary students, aged 13–18 participated in the Health Related Behavior General (HRBG) Survey in 1995–1996 and 2000–2001, respectively. Extracurricular sports participation at least weekly or as a team member (none, 1–2 events, 3 or more events), sedentary activities (0–1 h/day, 2 h/day or more) including television/video watching and homework were assessed. Additionally, physical self‐perceptions, physical fitness (fit/very fit, moderately fit, unfit/very unfit) and body weight (intention to lose weight, satisfied, intention to gain weight) were reported. Secular trends of sports participation, and sedentary activities and physical self‐perceptions were assessed.Results:  During the 5 years, the prevalence of sports participation (at least weekly or membership) decreased significantly in boys. The prevalence of both TV/video watching and homework for at least 2 h/day increased significantly in both sexes. The prevalence of being unfit/very unfit increased significantly in girls. No significant secular difference in weight perception was observed for both sexes.Conclusions:  Sports participation decreased and sedentary activities increased during the 5‐year period. Physical self‐perceptions did not change significantly, except an increase in being physically unfit was observed in girls.
Evaluation of a New Titanium‐Zirconium Dental Implant: A Biomechanical and Histological Comparative Study in the Mini Pig
Authors: Gottlow Jan , Dard Michel , Kjellson Fred , Obrecht Marcel , Sennerby Lars 
Published: June 2010

ABSTRACTBackground: Titanium zirconium alloy with 13–17% zirconium (TiZr1317) shows significantly better mechanical attributes than pure Ti with respect to elongation and fatigue strength. This material may be suitable for thin implants and implant components exposed to high mechanical constraints.Purpose: The aim of this study was to test the hypothesis that TiZr1317 and Ti implants show comparable osseointegration and stability.Materials and Methods: The mandibular premolars (P1, P2, P3) and the first molar (M1) in 12 adult miniature pigs were extracted 3 months prior to the study. Six specially designed implants made from Ti (commercially pure, Grade 4) or TiZr1317 (Roxolid®, Institut Straumann AG, Basel, Switzerland) with a hydrophilic sandblasted and acid‐etched (SLActive, Institut Straumann AG, Basel, Switzerland) surface were placed in each mandible; three standard implants modified for evaluation of removal torque (RT) in one side and three bone‐chamber implants for histologic observations in the contralateral side. RT tests were performed after 4 weeks when also the bone chamber implants and surrounding tissue were biopsied for histologic analyses in ground sections.Results: The RT results indicated significantly higher stability (p = 0.013) for TiZr1317 (230.9 ± 22.4 Ncm) than for Ti implants (204.7 ± 24.0 Ncm). The histology showed similar osteoconductive properties for both implant types. Histomorphometric measurements showed a statistically significant higher (p = 0.023) bone area within the chamber for the TiZr1317 implants (45.5 ± 13.2%) than did the Ti implants (40.2 ± 15.2%). No difference was observed concerning the bone to implant contact between the groups with 72.3 ± 20.5% for Ti and 70.2 ± 17.3% for TiZr1317 implants.Conclusion: It is concluded that the TiZr1317 implant with a hydrophilic sandblasted and acid‐etched surface showed similar or even stronger bone tissue responses than the Ti control implant
Short Communication: Use of a Diagnostic Software to Predict Bone Density and Implant Stability in Preoperative CTs
Authors: Pagliani Luca , Motroni Alessandro , Nappo Antonio , Sennerby Lars 
Published: June 2010

ABSTRACTBackground: Computerized tomographs (CTs) are commonly used for presurgical planning of dental implant placement. It is possible that implant stability can be predicted based on quantitative measurements of bone density at planned implants sites with the use of diagnostic software.Purpose: The aim was to evaluate if there is a correlation between bone density measurements in specific implant positions in preoperative CTs and insertion torque (IT) and implant stability measurements when placing the implants.Materials and Methods: The study comprised of four patients in whom presurgical CTs had been used to plan implant treatment. A total of 26 implants (Neoss, Harrogate, UK) were placed in the totally edentulous maxilla (n = 3) or mandible (n = 1). IT was measured during implant insertion and the torque/time curves examined for mean IT (newton‐centimeters) over the total curve. The stability of implants was measured with resonance frequency analysis. The positions of the implants were extracted from a postoperative CT to the preoperative one. Bone density was measured with a dedicated software (3Diagnosys™ 3.0, 3Diemme, Cantù, Italy) in virtual hollow probes, indicating the bone volume within 1 mm from each implant surface. The Spearman Rank correlation test was used to find possible correlations.Results: Statistically significant correlations were found between mean bone density, mean IT, and implant stability measurements.Conclusions: This pilot study showed a correlation between bone density, as measured in Hounsfield units in preoperative CTs, and IT and implant stability measurements at the surgical placement of the implants. The findings support the idea that integration of bone density measurements in implant probes in preoperative CTs using treatment‐planning software may be a useful feature to predict implant stability and to avoid failures.
Evaluation of the Effectiveness of a Water Lift System in the Sinus Membrane‐Lifting Operation as a Sinus Surgical Instrument
Authors: Kim Dae Y. , Itoh Yusaku , Kang Tae H. 
Published: June 2010

ABSTRACTPurpose: The effectiveness of a Water Lift System in the sinus membrane‐lifting operation was examined. This investigation focused on the capability of this equipment to reduce the risk of Schneiderian membrane perforation.Materials and Methods: A preliminary clinical study on the use of the Water Lift System in sinus membrane elevation to place implants through the sinus floor was conducted. A total of 70 sinus membrane‐lifting operations were performed on patients with various bone heights ranging from 1.2 to 9.9 mm (most commonly in the range of 4–6 mm) through the lateral approach (four cases) or the crestal approach (66 cases).Results: In all of the cases performed using the lateral approach, sinus membrane perforation did not occur. In the 66 cases performed using the crestal approach, Schneiderian membrane tearing occurred in two cases. The membrane tearing occurred during elevation of the Schneiderian membrane but not when a hole was drilled to access the Schneiderian membrane. One case of membrane tearing resulted from previous inflammation in the maxillary sinus, and the other case of membrane tearing was caused by application of excessive hydraulic pressure. In addition, similar outcomes were obtained and no microbial infections were observed in a total of 68 successful cases.Conclusions: In this study, the Water Lift System was confirmed to effectively reduce the risk of Schneiderian membrane perforation during the sinus membrane‐lifting operation. We conclude that the Water Lift System deserves to be considered as a sinus surgical instrument, which ensures safety in the sinus membrane‐lifting operation.
Prevalence, Risk Factors, and Predictors of Female Sexual Dysfunction in a Primary Care Setting: A Survey Finding
Authors: Ishak Izan H. , Low Wah-Yun , Othman Sajaratulnisah 
Published: June 2010

ABSTRACT

Introduction
Female sexual dysfunction (FSD) is a highly prevalent sexual health problem but poorly investigated at the primary care level.

Aim
This article examines the prevalence of sexual dysfunction and its possible risk factors associated with women at high risk of FSD in a hospital-based primary practice.

Methods
A validated Malay version of the Female Sexual Function Index (MVFSFI) was utilized to determine FSD in a cross-sectional study design, involving 163 married women, aged 18–65 years, in a tertiary hospital-based primary care clinic in Kuala Lumpur, Malaysia. Sociodemographic, marital profile, health, and lifestyle for women at high risk of FSD and those who were not at high risk were compared and their risk factors were determined.

Main Outcome Measures
Prevalence of FSD in Malaysian women based on the MVFSFI, and its risk factors for developing FSD.

Results
Some 42 (25.8%) out of 163 women had sexual dysfunction. Prevalence of sexual dysfunction increased significantly with age. Sexual dysfunctions were detected as desire problem (39.3%), arousal problem (25.8%), lubrication problem (21.5%), orgasm problem (16.6%), satisfaction problem (21.5%) and pain problems (16.6%). Women at high risk of FSD were significantly associated with age (OR 4.1, 95% CI 1.9 to 9.0), husband’s age (OR 4.3 95% C.I 1.9 to 9.3), duration of marriage (OR 3.3, 95% CI 1.6 to 6.8), medical problems (OR 8.5, 95% CI 3.3 to 21.7), menopausal status (OR 6.6, 95% CI 3.1 to 14.3), and frequency of sexual intercourse (OR 10.7, 95% CI 3.6 to 31.7). Multivariate analysis showed that medical problem (adjusted OR 4.6, 95% CI 1.6 to 14.0) and frequency of sexual intercourse (adjusted OR 7.2, 95% CI 2.1 to 24.0) were associated with increased risk of having FSD. Those who practiced contraception were less likely to have FSD.

Conclusion
Sexual health problems are prevalent in women attending primary care clinic where one in four women were at high risk of FSD. Thus, primary care physician should be trained and prepared to address this issue.