bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prenatal diagnosis of isolated total anomalous pulmonary venous connection: a series of 10 cases
Authors: Laux D. , Fermont L. , Bajolle F. , Boudjemline Y. , Stirnemann J. , Bonnet D. 
Published: May 2012

ABSTRACTObjectivesTo report on a series of 10 fetuses with prenatally diagnosed isolated total anomalous pulmonary venous connection (TAPVC), focusing on echocardiographic features leading to diagnosis, assess accuracy of prenatal diagnosis and describe postnatal outcome.MethodsIn this review of our experience of prenatal diagnosis of isolated TAPVC, we analyzed retrospectively medical records and fetal echocardiography findings in all cases with prenatal diagnosis of isolated TAPVC delivered between 1 January 2001 and 1 October 2011 at a tertiary referral center, paying special attention to echocardiographic signs that led to referral.ResultsDuring the study period, 95 infants with isolated TAPVC were seen at the center. Initially, expert fetal echocardiography identified 14 fetuses with isolated TAPVC. Prenatal diagnosis was made at a mean gestational age of 31 (range, 25–37) weeks. Ten true‐positive cases of TAPVC were confirmed after birth. The remaining four were considered false‐positive cases: two had normal heart with left superior vena cava to coronary sinus, one had partial anomalous venous connection and one was lost to follow‐up. Of the 85 diagnosed postnatally with TAPVC, only one had been seen prenatally by an expert cardiac sonographer. Echocardiographic signs leading to referral were related to pulmonary venous connection in half of the cases. Other suspected defects which led to referral were ostium prium atrial defect (n = 3), left–right asymmetry (n = 1), abnormal mitral valve (n = 1) and hepatic vascular malformation (n = 1). All infants with TAPVC underwent surgery. There was one postoperative death and nine survivors, with a mean follow‐up of 31 (range, 2–104) months.ConclusionFetal diagnosis of isolated TAPVC is challenging even for experts. Echocardiographic anomalies may appear late in gestation. New tools should be proposed to identify abnormal venous drainage at the screening level. Copyright © 2012 ISUOG. Published by John Wiley & Sons, Ltd.
Can angle of progression in pregnant women before onset of labor predict mode of delivery?
Authors: Levy R. , Zaks S. , Ben‐Arie A. , Perlman S. , Hagay Z. , Vaisbuch E. 
Published: May 2012

AbstractObjectivesThe angle of progression (AOP), measured by transperineal ultrasound, has been used to assess fetal head descent during labor. Our aim was to assess whether, before onset of labor, parous women have a narrower AOP than do nulliparous women and if a narrow AOP is associated with a higher rate of Cesarean delivery.MethodsIn this prospective, observational study, we performed transperineal ultrasound in pregnant women not yet in labor at ≥ 39 weeks' gestation who delivered within 1 week of sonography. The AOP was compared as follows: in nulliparous women, between those who had a Cesarean section and those who delivered vaginally; and among women who delivered vaginally, between those who were nulliparous and those who were parous.ResultsIncluded in the study were 100 nulliparous and 71 parous women. Among those who delivered vaginally (n = 161), the median AOP before onset of labor was narrower in parous than in nulliparous women (98° (interquartile range (IQR)), 90–107° vs 104° (IQR, 97–113°), P < 0.001). Among the 100 nulliparous women, (1) the median AOP before onset of labor was narrower in those who went on to deliver by Cesarean section (n = 9) than in those delivered vaginally (n = 91) (90° (IQR, 85.5–93.5°) vs 104° (IQR, 97–113°), P < 0.001); (2) an AOP ≥ 95° (derived from the receiver–operating characteristics curve) was associated with vaginal delivery in 99% of women; and (3) 89% (8/9) of women who delivered by Cesarean section had an AOP < 95°. Among the 71 parous women, only one delivered by Cesarean section and all of those with an AOP < 95° delivered vaginally.ConclusionA narrow AOP (< 95°) in non‐laboring nulliparous women at term is associated with a high rate of Cesarean delivery. Parous women have a narrower AOP than do nulliparous women before the onset of labor; however, unlike in nulliparous women, a narrow AOP in parous women does not appear to be associated with Cesarean delivery and most parous women with such an angle go on to deliver vaginally. Copyright © 2012 ISUOG. Published by John Wiley & Sons, Ltd.
The etiology and molecular genetics of human pigmentation disorders
Authors: Baxter Laura L. , Pavan William J. 
Published: May 2012

AbstractPigmentation, defined as the placement of pigment in skin, hair, and eyes for coloration, is distinctive because the location, amount, and type of pigmentation provides a visual manifestation of genetic heterogeneity in pathways regulating the pigment‐producing cells, melanocytes. The scope of this genetic heterogeneity in humans ranges from normal to pathological pigmentation phenotypes. Clinically, normal human pigmentation encompasses a variety of skin and hair color as well as punctate pigmentation such as melanocytic nevi (moles) or ephelides (freckles), while abnormal human pigmentation exhibits markedly reduced or increased pigment levels, known as hypopigmentation and hyperpigmentation, respectively. Elucidation of the molecular genetics underlying pigmentation has revealed genes important for melanocyte development and function. Furthermore, many pigmentation disorders show additional defects in cells other than melanocytes, and identification of the genetic insults in these disorders has revealed pleiotropic genes, where a single gene is required for various functions in different cell types. Thus, unravelling the genetics of easily visualized pigmentation disorders has identified molecular similarities between melanocytes and less visible cell types/tissues, arising from a common developmental origin and/or shared genetic regulatory pathways. Herein we discuss notable human pigmentation disorders and their associated genetic alterations, focusing on the fact that the developmental genetics of pigmentation abnormalities are instructive for understanding normal pathways governing development and function of melanocytes. WIREs Dev Biol 2013, 2:379–392. doi: 10.1002/wdev.72For further resources related to this article, please visit the WIREs website.This article is a U.S. Government work, and as such, is in the public domain in the United States of America.The authors declare no conflicts of interest.
Hydrogels for in vivo‐like three‐dimensional cellular studies
Authors: DeVolder Ross , Kong Hyun‐Joon 
Published: May 2012

AbstractExtensive efforts have been made to understand the effects of extracellular microenvironments on phenotypic activities for a wide array of stem, progenitor, and precursor cells. Hydrogels have emerged as invaluable platforms for examining the effects of extracellular matrix (ECM) properties on cell activities because of their several advantageous features. Specifically, hydrogels are unique materials that enable cell studies in three‐dimensional (3D) environments, similar to in vivo environments. Recently, there have been increasing efforts to assemble cell‐encapsulating hydrogels; however, hydrogel design strategies for 3D cell cultures have not been systematically discussed to date. Therefore, this review article summarizes current hydrogel designs for 3D cell culture studies and further discusses current challenges and potential resolutions for enhancing the controllability of hydrogel properties and microstructures. The hydrogels discussed herein include those of natural polymers (e.g., collagen, fibrinogen, alginate, and hyaluronic acids), synthetic polymers [e.g., poly(ethylene glycol) (PEG) and its derivatives], and mixtures of natural and synthetic polymers. We envision that hydrogels that enable 3D studies will greatly assist in the understanding of emergent cell behaviors, and ultimately become important biomedical tools for enhancing the quality of in vitro drug screening and clinical treatments. WIREs Syst Biol Med 2012 doi: 10.1002/wsbm.1174This article is categorized under:

Biological Mechanisms > Cell Fates
Models of Systems Properties and Processes > Cellular Models
Models of Systems Properties and Processes > Organ, Tissue, and Physiological Models
Developmental Biology > Stem Cell Biology and Regeneration
Microwave radiation and reactor design influence microbial communities during methane fermentation
Authors: Cydzik-Kwiatkowska Agnieszka , Zieliński Marcin , Jaranowska Paulina 
Published: May 2012

Abstract
The effect of reactor design and method of heating on the efficiency of methane fermentation and composition of microbial communities, especially methanogenic Archaea, were determined. The research was carried out using submerge- and trickling-bed reactors fed with wastewater and the heat supply into the reactors included a convection heating method and microwave radiation. The polymerase chain reaction-denaturing gradient gel electrophoresis and relative real-time PCR were used in order to assess the biofilm communities. The best fermentation results and the highest abundance of methanogenic Archaea in biomass were observed in microwave heated trickling-bed reactors. The research proved that in reactors of identical design, the application of microwaves enabled a higher fermentation efficiency to be obtained and simultaneously increased the diversity of methanogenic Archaea communities that favors process stability. All the identified sequences of Archaea belonged to Methanosarcina sp., suggesting that species from this genera are susceptible to non-thermal effects of microwaves. There were no effects from microwaves on the bacterial communities in both types of reactors, however, the bacterial species composition varied in the reactors of different design.
Intramedullary nails for pediatric diaphyseal femur fractures in older, heavier children: Early results
Authors: Reynolds Richard A. K. , Legakis Julie E. , Thomas Ronald , Slongo Theddy F. , Hunter James B. , Clavert Jean-Michel 
Published: May 2012

Purpose A common treatment for pediatric femur fractures is intramedullary nail (IMN) insertion. Elastic stable intramedullary nails (ESINs) are often used for these procedures in heavier patients, but the potential for complications and malunion is greater. We describe here a rigid IMN specifically designed for adolescents, the adolescent lateral entry femoral nail (ALFN). The purpose of this study was to compare the recovery and complications for patients treated with ESINs to those treated with the ALFN. Methods Our study design was a retrospective cohort study. We performed a review of medical records of 22 children ages 10–17 requiring surgical fixation of a femur fracture for a 2½-year period. Patients selected for the study had traumatic diaphyseal femur fractures and were treated with ESINs without end-caps or ALFNs. Our analyses evaluated injury, surgical, and outcome information for all patients. Results Twenty-two patients were eligible for inclusion and were divided into two groups according to their treatment: the ESIN group with 7 patients and the ALFN group with 15 patients. We then performed a comparison of complications and recovery for these patients. The mean time to full weight-bearing was significantly less for the ALFN group (4.1 weeks; SD, 2.2), than the ESIN group (9.4 weeks; SD 3.9). There was no statistical difference in the incidence of major or minor complications. Conclusions Older, heavier pediatric patients treated for femur fracture with ALFNs had a shorter recovery time than similar patients treated with ESINs. However, the outcomes for both groups were satisfactory.
Risques prostatiques de la testostérone : nouveau retour du balancier?
Authors: Buvat J. 
Published: May 2012

Résumé
Depuis les années 1940, la testostérone (T) est réputée dangereuse pour la prostate, bien que sans preuve solide. Les études longitudinales ne montrent pas de corrélation entre taux de T et incidence des cancers de la prostate (CaP), dont les formes graves sont au contraire associées à des taux faibles de cette hormone. Les essais cliniques randomisés contre placebo de traitement par la T n’ont pas montré d’augmentation de l’incidence du CaP dans les groupes T. Ces données rassurantes ont conduit certains à prescrire des traitements de substitution androgénique à des hommes porteurs de néoplasies intra-épithéliales prostatiques, ou précédemment traités pour un CaP de bon pronostic, ou sous surveillance active pour un tel cancer non traité, sans qu’apparaisse un risque élevé de progression ou de récidive du CaP sous ce traitement. Il ne fait pourtant aucun doute que la prostate normale et son cancer, au moins dans ses formes évoluées, sont faits de tissus androgénodépendants. Ces apparentes contradictions pourraient s’expliquer, outre par la possibilité d’une très faible diffusion de la T circulante dans le tissu prostatique, par l’hypothèse d’une saturation des récepteurs androgéniques prostatiques dès des niveaux très bas de T circulante, proches des taux de castration, expliquant qu’une augmentation de la T au-delà de ce niveau ne puisse pas stimuler le tissu prostatique. Quelques publications récentes d’évolution de CaP sous traitement androgénique, persistant parfois à l’arrêt de ce traitement, montrent qu’on ne peut pas généraliser les résultats très favorables des études précédentes. Des données objectives suggèrent aussi que le niveau de saturation du récepteur androgénique prostatique pourrait être en réalité proche de la limite inférieure des taux physiologiques de T. Il faut donc rester prudent avant d’élargir les indications du traitement par la T chez les hommes avec antécédent de CaP. Seules des études randomisées à grande échelle, en double insu contre placebo, permettront de se faire une idée exacte des risques auxquels expose ce traitement.
Mineral chemistry and thermobarometry of the staurolite-chloritoid schists from Poshtuk, NW Iran
Authors: SAKI ADEL , MOAZZEN MOHSSEN , OBERHÄNSLI ROLAND 
Published: May 2012

AbstractThe Poshtuk metapelitic rocks in northwestern Iran underwent two main phases of regional and contact metamorphism. Microstructures, textural features and field relations indicate that these rocks underwent a polymetamorphic history. The dominant metamorphic assemblage of the metapelites is garnet, staurolite, chloritoid, chlorite, muscovite and quartz, which grew mainly syntectonically during the later contact metamorphic event. Peak metamorphic conditions of this event took place at 580 °C and ~3–4 kbar, indicating that this event occurred under high-temperature and low-pressure conditions (HT/LP metamorphism), which reflects the high heat flow in this part of the crust. This event is mainly controlled by advective heat input through magmatic intrusions into all levels of the crust. These extensive Eocene metamorphic and magmatic activities can be associated with the early Alpine Orogeny, which resulted in this area from the convergence between the Arabian and Eurasian plates, and the Cenozoic closure of the Tethys oceanic tract(s).
Singularity, isotropy, and velocity transmission evaluation of a three translational degrees-of-freedom parallel robot
Authors: Zhao Yongjie 
Published: May 2012

SUMMARYPerformance evaluation of a parallel robot is a multicriteria problem. By taking Delta robot as an object of study, this paper presents the kinematic performance evaluation of a three translational degrees-of-freedom parallel robot from the viewpoint of singularity, isotropy, and velocity transmission. It is shown that the determinant of a Jacobian matrix cannot measure the distance from the singular configuration due to the existing inverse kinematic singularity of a Delta robot. The determinants of inverse and direct kinematic Jacobian matrices are adopted for the measurement of distance from the singular configuration based on the theory of numerical linear dependence. The denominator of the Jacobian matrix will be lost in the computation of the condition number when the end-effector is on the centerline of the workspace, so the Delta robot may also be nearly at a singular configuration when the condition number of the Jacobian matrix is equal to 1. The velocity transmission index whose physical meaning is the maximum input angular velocity when the end-effector translates in the unit velocity is presented. The evaluation of singularity, isotropy, and velocity transmission of a Delta robot is investigated by simulation. The velocity transmission index can also be used for the velocity transmission evaluation of a parallel robot with pure rotational degrees-of-freedom based on the principle of similarity. The physical meaning is modified to be the maximum input velocity when the end-effector rotates in the unit angular velocity.
Student Perception of High Fidelity Medical Simulation for an International Trauma Life Support Course
Authors: Kim Tae Eung , Reibling Ellen T. , Denmark Kent T. 
Published: May 2012

AbstractBackground: High fidelity medical simulators (HFMS) are accepted tools for health care instruction. The use of HFMS was incorporated into an International Trauma Life Support course, and course participants were surveyed regarding attitudes toward HFMS.Methods: Course participants, including physicians, nurses, and prehospital personnel, were given pre- and post-course questionnaires measuring their confidence in knowledge and treatment of trauma resuscitation, as well as their attitudes towards the utility and realism of immersive simulation. The participants were randomly assigned to take a course examination either before or after their simulator session.Results: Thirteen course participants of varying backgrounds and degrees of clinical experience were surveyed and tested. All surveyed areas improved following simulator training, including comfort level with simulation as a training method (17%), perception of the realism of HFMS (15%), and reported self-confidence in knowledge, experience and training in trauma care (27%). Test scores were improved in the post-simulation group as opposed to the pre-simulation group (86% pass rate in the post-simulation test group versus 50% pass rate in the pre-simulation test group).Conclusions: High fidelity medical simulation was accepted by medical professionals of different backgrounds and experience. Attitudes towards simulation and self-confidence improved after simulator sessions, as did test scores, suggesting improved comprehension and retention of course materials. Further testing is required to validate the findings of this small, observational study.
Literature Review of Disaster Health Research in Japan: Focusing on Disaster Nursing Education
Authors: Kako Mayumi , Mitani Satoko , Arbon Paul 
Published: May 2012

AbstractIntroductionJapan has a long history of disaster due to its location on the “Pacific Ring of Fire.” The frequency of earthquakes experienced in recent years has had significant influence on disaster health research in Japan. This paper describes disaster health research trends in Japan, with an emphasis on disaster nursing research.MethodA systematic literature review of disaster health research in Japan from 2001 through 2007 was conducted for this study. The most commonly used database in Japan, Ichushi (version 4.0), was used for this literature review. The keywords and sub-keywords used were: disaster, disaster nursing, practice, education, ability, response, emergency, licensure, capability, function, prevention, planning and research. These keywords were sometimes used in combination to identify relevant literature.ResultsA total of 222 articles were reviewed. The number of research papers available increased gradually from 2001 through 2007. The most common articles used were found using the search category of “disaster nursing and research.” Among the search categories, “disaster nursing and education” also had a high number of publications. This category also peaked in 2007.ConclusionThe recent experiences of natural disaster in Japan accelerated the impetus to explore and implement a disaster nursing concept into practice and nursing curricula. Further evidence-based studies to develop methodology and other areas of studies in disaster nursing, including other language databases are to be expected in the future.Kako M, Mitani S, Arbon P. Literature review of disaster health research in Japan: focusing on disaster nursing education. Prehosp Disaster Med. 2012;27(2):1-6.
An examination of environmental correlates with childhood height-for-age in Ghana
Authors: Nikoi Ebenezer , Anthamatten Peter 
Published: May 2012

AbstractObjectiveThe relationship between a child's environment and nutritional status is difficult to examine yet could offer an important guide to policy. The objective of the present work was to examine individual and environmental correlates with childhood height-for-age in Ghana.DesignData were derived from the 2008 MEASURE Demographic and Health Survey in Ghana, the 2000 Ghana Population and Housing Census, and the World Wide Fund for Nature's eco-regions database. A generalized linear mixed regression model was used to estimate the effects of individual and environmental correlates on height-for-age.SubjectsThe study examined 2225 Ghanaian children aged 0–59 months.SettingThe setting was all districts in Ghana for the year 2008.ResultsAfter accounting for individual characteristics of children, mothers and households, height-for-age was significantly associated with population density. Other significantly associated variables in the final model were the age of the child, vaccination status, the size of the child at birth, months of breast-feeding, mother's BMI, whether the child's mother had health insurance and wealth quintile.ConclusionsIn addition to a number of characteristics of the children and their households, the social milieu is important to understanding differences in height-for-age among children in Ghana. The biophysical environment was not associated with height-for-age.
Health behaviours and health-care utilization in Canadian schoolchildren
Authors: Kirk Sara FL , Kuhle Stefan , Ohinmaa Arto , Veugelers Paul J 
Published: May 2012

AbstractObjectivePoor nutritional habits and physical inactivity are two health behaviours believed to be linked with increasing rates of overweight and obesity in children. The objective of the present study was to determine whether children who reported healthier behaviours, specifically in relation to nutrition and physical activity, also had lower health-care utilization.DesignPopulation-based cross-sectional study, linking survey data from the 2003 Children's Lifestyle and School Performance Study (CLASS) with Nova Scotia administrative health data. Health-care utilization was defined as both (i) the total physician costs and (ii) the number of physician visits, for each child from 2001 to 2006. Exposures were two indices of healthy eating, the Diet Quality Index and the Healthy Eating Index, and self-reported physical activity and screen time behaviours.SettingElementary schools in the Canadian province of Nova Scotia.SubjectsGrade 5 students and their parents; of the 5200 students who participated in CLASS and completed surveys, 4380 (84 %) could be linked with information in the administrative data sets.ResultsThe study found a relationship between both indices of healthy eating and a borderline significant trend towards lower health-care utilization in this population sample of children. No statistically significant relationships were seen for physical activity or screen time.ConclusionsBoth measures of diet quality produced similar results. The study suggests that healthy eating habits established in childhood may be associated with lower health-care utilization, although further research over a longer time frame is needed to demonstrate statistical significance.