bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safeguarding human values: rethinking US law for generative AI’s societal impacts
Authors: Cheong Inyoung , Caliskan Aylin , Kohno Tadayoshi 
Published: May 2024

AbstractOur interdisciplinary study examines the effectiveness of US law in addressing the complex challenges posed by generative AI systems to fundamental human values, including physical and mental well-being, privacy, autonomy, diversity, and equity. Through the analysis of diverse hypothetical scenarios developed in collaboration with experts, we identified significant shortcomings and ambiguities within the existing legal protections. Constitutional and civil rights law currently struggles to hold AI companies responsible for AI-assisted discriminatory outputs. Moreover, even without considering the liability shield provided by Section 230, existing liability laws may not effectively remedy unintentional and intangible harms caused by AI systems. Demonstrating causal links for liability claims such as defamation or product liability proves exceptionally difficult due to the intricate and opaque nature of these systems. To effectively address these unique and evolving risks posed by generative AI, we propose a “Responsible AI Legal Framework” that adapts to recognize new threats and utilizes a multi-pronged approach. This framework would enshrine fundamental values in legal frameworks, establish comprehensive safety guidelines, and implement liability models tailored to the complexities of human-AI interactions. By proactively mitigating unforeseen harms like mental health impacts and privacy breaches, this framework aims to create a legal landscape capable of navigating the exciting yet precarious future brought forth by generative AI technologies.
Is ChatGPT the way toward artificial general intelligence
Authors: Emmert-Streib Frank 
Published: May 2024

AbstractThe success of the conversational AI system ChatGPT has triggered an avalanche of studies that explore its applications in research and education. There are also high hopes that, in addition to such particular usages, it could lead to artificial general intelligence (AGI) that means to human-level intelligence. Such aspirations, however, need to be grounded by actual scientific means to ensure faithful statements and evaluations of the current situation. The purpose of this article is to put ChatGPT into perspective and to outline a way forward that might instead lead to an artificial special intelligence (ASI), a notion we introduce. The underlying idea of ASI is based on an environment that consists only of text. We will show that this avoids the problem of embodiment of an agent and leads to a system with restricted capabilities compared to AGI. Furthermore, we discuss gated actions as a means of large language models to moderate ethical concerns.
Global Burden and Trends of Primary Liver Cancer Attributable to Comorbid Type 2 Diabetes Mellitus Among People Living with Hepatitis B: An Observational Trend Study from 1990 to 2019
Authors: Xie Jinzhao , Lin Xiao , Fan Xiaoyan , Wang Xu , Pan Deng , Li Jinghua , Hao Yuantao , Jie Yusheng , Zhang Lei , Gu Jing 
Published: May 2024

Abstract
Background
Type 2 diabetes mellitus (T2DM) increases the risk of liver cancer among people living with hepatitis B virus (HBV). Our study aimed to estimate the global burden and trends of liver cancer attributable to comorbid T2DM among people living with HBV from 1990 to 2019.

Methods
We calculated the population attributable fractions (PAFs) of liver cancer attributable to comorbid T2DM among the burden of HBV-related liver cancer. We applied the PAFs to the burden of HBV-related liver cancer derived from the Global Burden of Disease (GBD) 2019 database to obtain the burden of liver cancer attributable to HBV–T2DM comorbidity. The prevalence, disability-adjusted life year (DALY), and deaths of liver cancer attributable to the comorbidity were assessed at the global, regional, and country levels and then stratified by the sociodemographic index (SDI), sex, and age group. Estimated annual percentage changes (EAPCs) were calculated to quantify the temporal trends.

Results
In 2019, the global age-standardized prevalence and DALY rates of liver cancer attributable to HBV–T2DM comorbidity were 9.9 (8.4–11.5) and 182.4 (154.9–212.7) per 10,000,000 individuals, respectively. High-income Asia Pacific and East Asia had the highest age-standardized prevalence and DALY rates of liver cancer attributable to HBV–T2DM comorbidity, respectively. From 1990 to 2019, age-standardized prevalence and DALY rates increased in 16 out of 21 GBD regions. High-income North America had the largest annual increases in both age-standardized prevalence rates (EAPC = 6.07; 95% UI, 5.59 to 6.56) and DALY rates (EAPC = 4.77; 95% UI, 4.35 to 5.20), followed by Australasia and Central Asia. Across all SDI regions, the high SDI region exhibited the most rapid increase in age-standardized prevalence and DALY rates from 1990 to 2019. Additionally, men had consistently higher disease burdens than women across all age groups. The patterns of mortality burden and trends are similar to those of DALYs.

Conclusions
The burden of liver cancer attributable to comorbid T2DM among people living with HBV has exhibited an increasing trend across most regions over the last three decades. Tailored prevention strategies targeting T2DM should be implemented among individuals living with HBV.
Studies on partial replacement of waste high density polyethylene (HDPE) and polypropylene (PP) plastic with fine aggregate (FA) on mechanical, durability and thermal properties of M30 and M40 grade concrete
Authors: Suvidha Y. , Jain Sumesh , Kumar C. Arvind 
Published: May 2024

AbstractThe aim of the present paper is to incorporate two different waste plastic materials that is High-Density Polyethylene (HDPE) and Poly-Propylene (PP), were replaced with Fine Aggregate (FA) at a 10% by 2.5% increment. The widespread formation of HDPE and PP waste plastics has become a major environmental issue, endangering ecosystems and human health. Traditional disposal techniques, such as landfills and incineration, lead to pollution and resource depletion. Incorporating these polymers into concrete provides a long-term solution that reduces environmental effect while improving material qualities. The Different tests conducted are compressive strength (3, 7, 28 and 60 days) (150 × 150x150 mm), flexural strength (3, 7, 28 and 60 days) (100 × 100x500 mm), acid attack (28, 56 and 90 days) (100 × 100x100 mm), sulphate attack (28, 56 and 90 days) (100 × 100x100 mm), and thermal conductivity (180 mm dia x 20 mm thick). The compressive strengths of 40.52 MPa and 38.41 MPa for PP and HDPE material were observed in M30-grade concrete, respectively. Similarly, for M40-grade concrete, 43.6 MPa and 41.8 MPa are for PP and HDPE material, respectively. The optimum percentages of 5% and 7.5 for PP and HDPE material, respectively, can be replaced in concrete for flexural strength in both M30 and M40 grades. The least percentage loss in acid attack was observed at 28 days for both HDPE and PP material, but for 56 days and 90 days, the percentage loss of weight was significantly less (< 5%). The sulphate attack for both M30 and M40 grade concrete showed less than 10% percentage loss in weight after 90 days. Thermal conductivity (k) was also reduced by 30–35% for both HDPE and PP material, with 10% replacement in concrete for M30 and M40 grades. The use of Waste HDPE and PP material can be used to improve the mechanical, durability & thermal property of M30 and M40 grade concrete under controlled conditions.
Pathologic characteristics of histiocytic and dendritic cell neoplasms
Authors: Yoon Sun Och 
Published: May 2024

AbstractHistiocytic and dendritic cell neoplasms comprise diverse tumors originating from the mononuclear phagocytic system, which includes monocytes, macrophages, and dendritic cells. The 5th edition of the World Health Organization (WHO) classification updating the categorization of these tumors, reflecting a deeper understanding of their pathogenesis.In this updated classification system, tumors are categorized as Langerhans cell and other dendritic cell neoplasms, histiocyte/macrophage neoplasms, and plasmacytoid dendritic cell neoplasms. Follicular dendritic cell neoplasms are classified as mesenchymal dendritic cell neoplasms within the stroma-derived neoplasms of lymphoid tissues.Each subtype of histiocytic and dendritic cell neoplasms exhibits distinct morphological characteristics. They also show a characteristic immunophenotypic profile marked by various markers such as CD1a, CD207/langerin, S100, CD68, CD163, CD4, CD123, CD21, CD23, CD35, and ALK, and hematolymphoid markers such as CD45 and CD43. In situ hybridization for EBV-encoded small RNA (EBER) identifies a particular subtype. Immunoprofiling plays a critical role in determining the cell of origin and identifying the specific subtype of tumors. There are frequent genomic alterations in these neoplasms, especially in the mitogen-activated protein kinase pathway, including BRAF (notably BRAF V600E), MAP2K1, KRAS, and NRAS mutations, and ALK gene translocation.This review aims to offer a comprehensive and updated overview of histiocytic and dendritic cell neoplasms, focusing on their ontogeny, morphological aspects, immunophenotypic profiles, and molecular genetics. This comprehensive approach is essential for accurately differentiating and classifying neoplasms according to the updated WHO classification.
Revisiting Taylor’s analysis of the Trinity test
Authors: Mone Elizabeth , Seshadri Pranay 
Published: May 2024

Abstract
The atomic bomb uses fission of heavy elements to produce a large amount of energy. It was designed and deployed during World War II by the United States military. The first test of an atomic bomb occurred in July 1945 in New Mexico and was given the name Trinity; this test was not declassified until 1949. In that year, Geoffrey Ingram Taylor released two papers detailing his process in calculating the energy yield of the atomic bomb from pictures of the Trinity explosion alone. Many scientists made similar calculations concurrently, although Taylor is often accredited with them. Since then, many scientists have also attempted to calculate a yield through various methods. This paper walks through these methods with a focus on Taylor’s method—based on first principles—as well as redoing the calculations that he performed with modern tools. In this paper, we make use of state-of-the-art computer vision tools to find a more precise measurement of the blast radius, as well as using curve fitting and numerical integration methods. With more precise measurements we are able to follow in Taylor’s footstep toward a more accurate approximation.
Socio-ecological factors linked with changes in adults’ dietary intake in Los Angeles County during the peak of the coronavirus 2019 pandemic
Authors: Miller Sydney , Pickering Trevor A , Bruine de Bruin Wändi , Valente Thomas W. , Wilson John P , de la Haye Kayla 
Published: May 2024

Abstract

Objective:
Comprehensive studies examining longitudinal predictors of dietary change during the coronavirus disease 2019 pandemic are lacking. Based on an ecological framework, this study used longitudinal data to test if individual, social and environmental factors predicted change in dietary intake during the peak of the coronavirus 2019 pandemic in Los Angeles County and examined interactions among the multilevel predictors.

Design:
We analysed two survey waves (e.g. baseline and follow-up) of the Understanding America Study, administered online to the same participants 3 months apart. The surveys assessed dietary intake and individual, social, and neighbourhood factors potentially associated with diet. Lagged multilevel regression models were used to predict change from baseline to follow-up in daily servings of fruits, vegetables and sugar-sweetened beverages.

Setting:
Data were collected in October 2020 and January 2021, during the peak of the coronavirus disease 2019 pandemic in Los Angeles County.

Participants:
903 adults representative of Los Angeles County households.

Results:
Individuals who had depression and less education or who identified as non-Hispanic Black or Hispanic reported unhealthy dietary changes over the study period. Individuals with smaller social networks, especially low-income individuals with smaller networks, also reported unhealthy dietary changes. After accounting for individual and social factors, neighbourhood factors were generally not associated with dietary change.

Conclusions:
Given poor diets are a leading cause of death in the USA, addressing ecological risk factors that put some segments of the community at risk for unhealthy dietary changes during a crisis should be a priority for health interventions and policy.
Non‐Geophysical Interhemispheric Asymmetries in Large Magnetic Field Residuals Between Swarm Observations and Earth Magnetic Field Models During Moderate to Quiet Geomagnetic Conditions
Authors: Shi Yining , Moldwin Mark B. 
Published: May 2024

AbstractWe present a statistical study of large magnetic field vector residuals between Swarm observations and the 13th generation International Geomagnetic Reference Field (IGRF‐13) model under quiet to moderate geomagnetic conditions. Since the vast majority of data are taken during these conditions, statistics of these large residuals are important for satellite operation when using IGRF‐13 as reference, as well as for magnetosphere‐ionosphere‐thermosphere studies. Residuals with magnitude of vector differences between observations and model estimations larger than 300 nT under Dst > −50 nT are studied from 2014 to 2020. All large residuals appear in the high‐latitude auroral zone region peaking around 70° (−70°) magnetic latitude (MLAT) in the northern hemisphere (southern hemisphere) with also a secondary occurrence peak just below 80° (−80°) MLAT. However, the two hemispheres show clear asymmetries in the magnetic longitude and magnetic local time distribution where both hemispheres show high concentration of large residuals around the geographic poles. Since polar satellite's orbits give rise to highly biased number of observations around the geographic poles, it results in a decrease in occurrence rate with respect to the total number of measurements. We suggest that the asymmetries of large residuals in the two hemispheres around the geographic pole are not geophysical, but due to satellite orbit bias around the geographic poles and difference between IGRF and observations due to model error and geophysical processes not included in the model. Identifying these biases is helpful to better separate out geophysical electric current signatures from non‐geophysical ones.
Waveform Fitting of Receiver Functions for Enhanced Retrieval of Crustal Structure in the Presence of Sediments
Authors: Akinremi Stephen , van der Meijde Mark , Thomas Christine , Afonso Juan Carlos , Ruigrok Elmer , Fadel Islam 
Published: May 2024

AbstractThe receiver function technique is widely used to image crustal structure using P‐to‐S converted phases at the Moho discontinuity. However, the presence of sedimentary layer generates additional P‐to‐S conversions and reverberations, which can overprint the Moho phases and pose problems in imaging crustal structure with standard receiver function techniques. We introduce a robust two‐step method that uses H‐κ stacking to determine average thickness and Vp/Vs of the sedimentary layer, followed by waveform‐fitting of the observed receiver function to constrain the average crustal thickness and sub‐sediment Vp/Vs. We tested the method using both synthetic data and real‐data from stations located on sedimentary layers in the Netherlands and USA. We show that the new method outperforms other common approaches in retrieving accurate Moho depth and sub‐sediment Vp/Vs estimates, even in cases where the Moho phases are completely overprinted by large‐amplitude phases related to sedimentary layers.
Effects of ebselen addition on emotional processing and brain neurochemistry in depressed patients unresponsive to antidepressant medication
Authors: Ramli Fitri Fareez , Singh Nisha , Emir Uzay E. , Villa Luca M. , Waters Shona , Harmer Catherine J. , Cowen Philip J. , Godlewska Beata R. 
Published: May 2024

AbstractLithium is an effective augmenting agent for depressed patients with inadequate response to standard antidepressant therapy, but numerous adverse effects limit its use. We previously reported that a lithium-mimetic agent, ebselen, promoted a positive emotional bias—an indicator of potential antidepressant activity in healthy participants. We therefore aimed to investigate the effects of short-term ebselen treatment on emotional processing and brain neurochemistry in depressed patients with inadequate response to standard antidepressants. We conducted a double-blind, placebo-controlled 7-day experimental medicine study in 51 patients with major depressive disorder who were currently taking antidepressants but had an inadequate response to treatment. Participants received either ebselen 600 mg twice daily for seven days or identical matching placebo. An emotional testing battery, magnetic resonance spectroscopy and depression and anxiety rating scales were conducted at baseline and after seven days of treatment. Ebselen did not increase the recognition of positive facial expressions in the depressed patient group. However, ebselen increased the response bias towards fear emotion in the signal detection measurement. In the anterior cingulate cortex, ebselen significantly reduced the concentrations of inositol and Glx (glutamate+glutamine). We found no significant differences in depression and anxiety rating scales between visits. Our study did not find any positive shift in emotional bias in depressed patients with an inadequate response to antidepressant medication. We confirmed the ability of ebselen to lower inositol and Glx in the anterior cingulate cortex. These latter effects are probably mediated through inhibition of inositol monophosphatase and glutaminase respectively.
Spatially revealed roles for lncRNAs in Drosophila spermatogenesis, Y chromosome function and evolution
Authors: Shao Zhantao , Hu Jack , Jandura Allison , Wilk Ronit , Jachimowicz Matthew , Ma Lingfeng , Hu Chun , Sundquist Abby , Das Indrani , Samuel-Larbi Phillip , Brill Julie A. , Krause Henry M. 
Published: May 2024

AbstractUnlike coding genes, the number of lncRNA genes in organism genomes is relatively proportional to organism complexity. From plants to humans, the tissues with highest numbers and levels of lncRNA gene expression are the male reproductive organs. To learn why, we initiated a genome-wide analysis of Drosophila lncRNA spatial expression patterns in these tissues. The numbers of genes and levels of expression observed greatly exceed those previously reported, due largely to a preponderance of non-polyadenylated transcripts. In stark contrast to coding genes, the highest numbers of lncRNAs expressed are in post-meiotic spermatids. Correlations between expression levels, localization and previously performed genetic analyses indicate high levels of function and requirement. More focused analyses indicate that lncRNAs play major roles in evolution by controlling transposable element activities, Y chromosome gene expression and sperm construction. A new type of lncRNA-based particle found in seminal fluid may also contribute to reproductive outcomes.
3D printing with a 3D printed digital material filament for programming functional gradients
Authors: Ahn Sang-Joon , Lee Howon , Cho Kyu-Jin 
Published: May 2024

AbstractAdditive manufacturing, or 3D printing attracts growing attention as a promising method for creating functionally graded materials. Fused deposition modeling (FDM) is widely available, but due to its simple process, creating spatial gradation of diverse properties using FDM is challenging. Here, we present a 3D printed digital material filament that is structured towards 3D printing of functional gradients, utilizing only a readily available FDM printer and filaments. The DM filament consists of multiple base materials combined with specific concentrations and distributions, which are FDM printed. When the DM filament is supplied to the same printer, its constituent materials are homogeneously blended during extrusion, resulting in the desired properties in the final structure. This enables spatial programming of material properties in extreme variations, including mechanical strength, electrical conductivity, and color, which are otherwise impossible to achieve with traditional FDMs. Our approach can be readily adopted to any standard FDM printer, enabling low-cost production of functional gradients.
Complete male-to-female sex reversal in XY mice lacking the miR-17~92 cluster
Authors: Hurtado Alicia , Mota-Gómez Irene , Lao Miguel , Real Francisca M. , Jedamzick Johanna , Burgos Miguel , Lupiáñez Darío G. , Jiménez Rafael , Barrionuevo Francisco J. 
Published: May 2024

AbstractMammalian sex determination is controlled by antagonistic gene cascades operating in embryonic undifferentiated gonads. The expression of the Y-linked gene SRY is sufficient to trigger the testicular pathway, whereas its absence in XX embryos leads to ovarian differentiation. Yet, the potential involvement of non-coding regulation in this process remains unclear. Here we show that the deletion of a single microRNA cluster, miR-17~92, induces complete primary male-to-female sex reversal in XY mice. Sry expression is delayed in XY knockout gonads, which develop as ovaries. Sertoli cell differentiation is reduced, delayed and unable to sustain testicular development. Pre-supporting cells in mutant gonads undergo a transient state of sex ambiguity which is subsequently resolved towards the ovarian fate. The miR-17~92 predicted target genes are upregulated, affecting the fine regulation of gene networks controlling gonad development. Thus, microRNAs emerge as key components for mammalian sex determination, controlling Sry expression timing and Sertoli cell differentiation.
Universal Murray’s law for optimised fluid transport in synthetic structures
Authors: Zhou Binghan , Cheng Qian , Chen Zhuo , Chen Zesheng , Liang Dongfang , Munro Eric Anthony , Yun Guolin , Kawai Yoshiki , Chen Jinrui , Bhowmick Tynee , Padmanathan Karthick Kannan , Occhipinti Luigi Giuseppe , Matsumoto Hidetoshi , Gardner Julian William , Su Bao-Lian , Hasan Tawfique 
Published: May 2024

AbstractMaterials following Murray’s law are of significant interest due to their unique porous structure and optimal mass transfer ability. However, it is challenging to construct such biomimetic hierarchical channels with perfectly cylindrical pores in synthetic systems following the existing theory. Achieving superior mass transport capacity revealed by Murray’s law in nanostructured materials has thus far remained out of reach. We propose a Universal Murray’s law applicable to a wide range of hierarchical structures, shapes and generalised transfer processes. We experimentally demonstrate optimal flow of various fluids in hierarchically planar and tubular graphene aerogel structures to validate the proposed law. By adjusting the macroscopic pores in such aerogel-based gas sensors, we also show a significantly improved sensor response dynamics. In this work, we provide a solid framework for designing synthetic Murray materials with arbitrarily shaped channels for superior mass transfer capabilities, with future implications in catalysis, sensing and energy applications.