bluuebunny/crossref_metadata_2025_split huggingface dataset:
National surveillance using a clinical quality indicator for prolonged antipsychotic use among older Australians with dementia who access aged care services
Authors: Sluggett Janet K. , Caughey Gillian E. , Air Tracy , Cations Monica , Lang Catherine E. , Ward Stephanie A. , Ahern Susannah , Lin Xiaoping , Wallis Kasey , Crotty Maria , Inacio Maria C. 
Published: April 2024

AbstractObjectivesDementia guidelines recommend antipsychotics are only used for behavioral and psychological symptoms when non‐drug interventions fail, and to regularly review use. Population‐level clinical quality indicators (CQIs) for dementia care in permanent residential aged care (PRAC) typically monitor prevalence of antipsychotic use but not prolonged use. This study aimed to develop a CQI for antipsychotic use >90 days and examine trends, associated factors, and variation in CQI incidence; and examine duration of the first episode of use among individuals with dementia accessing home care packages (HCPs) or PRAC.MethodsRetrospective cohort study, including older individuals with dementia who accessed HCPs (n = 50,257) or PRAC (n = 250,196). Trends in annual CQI incidence (2011–12 to 2015–16) and associated factors were determined using Poisson regression. Funnel plots examined geographical and facility variation. Time to antipsychotic discontinuation was estimated among new antipsychotic users accessing HCP (n = 2367) and PRAC (n = 15,597) using the cumulative incidence function.ResultsBetween 2011–12 and 2015–16, antipsychotic use for >90 days decreased in HCP recipients from 10.7% (95% CI 10.2–11.1) to 10.1% (95% CI 9.6–10.5, adjusted incidence rate ratio (aIRR) 0.97 (95% CI 0.95–0.98)), and in PRAC residents from 24.5% (95% CI 24.2–24.7) to 21.8% (95% CI 21.5–22.0, aIRR 0.97 (95% CI 0.96–0.98)). Prior antipsychotic use (both cohorts) and being male and greater socioeconomic disadvantage (PRAC cohort) were associated with higher CQI incidence. Little geographical/facility variation was observed. Median treatment duration in HCP and PRAC was 334 (interquartile range [IQR] 108–958) and 555 (IQR 197–1239) days, respectively.ConclusionsWhile small decreases in antipsychotic use >90 days were observed between 2011–12 and 2015–16, findings suggest antipsychotic use among aged care recipients with dementia can be further minimized.
Gene expression markers in peripheral blood and outcome in patients with platinum‐resistant ovarian cancer: A study of the European GANNET53 consortium
Authors: Obermayr Eva , Mohr Thomas , Schuster Eva , Braicu Elena Ioana , Taube Eliane , Sehouli Jalid , Vergote Ignace , Pujade‐Lauraine Eric , Ray‐Coquard Isabelle , Harter Philipp , Wimberger Pauline , Joly‐Lobbedez Florence , Mahner Sven , Moll Ute Martha , Concin Nicole , Zeillinger Robert 
Published: April 2024

AbstractDisease progression is a major problem in ovarian cancer. There are very few treatment options for patients with platinum‐resistant ovarian cancer (PROC), and therefore, these patients have a particularly poor prognosis. The aim of the present study was to identify markers for monitoring the response of 123 PROC patients enrolled in the Phase I/II GANNET53 clinical trial, which evaluated the efficacy of Ganetespib in combination with standard chemotherapy versus standard chemotherapy alone. In total, 474 blood samples were collected, comprising baseline samples taken before the first administration of the study drugs and serial samples taken during treatment until further disease progression (PD). After microfluidic enrichment, 27 gene transcripts were analyzed using quantitative polymerase chain reaction and their utility for disease monitoring was evaluated. At baseline, ERCC1 was associated with an increased risk of PD (hazard ratio [HR] 1.75, 95% confidence interval [CI]: 1.20–2.55; p = 0.005), while baseline CDH1 and ESR1 may have a risk‐reducing effect (CDH1 HR 0.66, 95% CI: 0.46–0.96; p = 0.024; ESR1 HR 0.58, 95% CI: 0.39–0.86; p = 0.002). ERCC1 was observed significantly more often (72.7% vs. 53.9%; p = 0.032) and ESR1 significantly less frequently (59.1% vs. 78.3%; p = 0.018) in blood samples taken at radiologically confirmed PD than at controlled disease. At any time during treatment, ERCC1‐presence and ESR1‐absence were associated with short PFS and with higher odds of PD within 6 months (odds ratio 12.77, 95% CI: 4.08–39.97; p < 0.001). Our study demonstrates the clinical relevance of ESR1 and ERCC1 and may encourage the analysis of liquid biopsy samples for the management of PROC patients.
Associations between pathological features and risk of metachronous colorectal cancer
Authors: Zhang Ye , Win Aung Ko , Makalic Enes , Buchanan Daniel D. , Pai Rish K. , Phipps Amanda I. , Rosty Christophe , Boussioutas Alex , Karahalios Amalia , Jenkins Mark A. 
Published: April 2024

AbstractSurvivors of colorectal cancer (CRC) are at risk of developing another primary colorectal cancer ‐ metachronous CRC. Understanding which pathological features of the first tumour are associated with risk of metachronous CRC might help tailor existing surveillance guidelines. Population‐based CRC cases were recruited from the United States, Canada and Australia between 1997 and 2012 and followed prospectively until 2022 by the Colon Cancer Family Registry. Metachronous CRC was defined as a new primary CRC diagnosed at least 1 year after the initial CRC. Those with the genetic cancer predisposition Lynch syndrome or MUTYH mutation carriers were excluded. Cox regression models were fitted to estimate hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) for the associations. Of 6085 CRC cases, 138 (2.3%) were diagnosed with a metachronous CRC over a median follow‐up time of 12 years (incidence: 2.0 per 1000 person‐years). CRC cases with a synchronous CRC were 3.4‐fold more likely to develop a metachronous CRC (adjusted HR: 3.36, 95% CI: 1.89–5.98) than those without a synchronous tumour. CRC cases with MMR‐deficient tumours had a 72% increased risk of metachronous CRC (adjusted HR: 1.72, 95% CI: 1.11–2.64) compared to those with MMR‐proficient tumours. Compared to cases who had an adenocarcinoma histologic type, those with an undifferentiated histologic type were 77% less likely to develop a metachronous CRC (adjusted HR: 0.23, 95% CI: 0.06–0.94). Existing surveillance guidelines for CRC survivors could be updated to include increased surveillance for those whose first CRC was diagnosed with a synchronous CRC or was MMR‐deficient.
Bonding of ceramics to silver‐coated titanium—A combined theoretical and experimental study
Authors: Vuorinen Vesa , Kouhia Reijo , Könönen Mauno , Kivilahti Jorma K. 
Published: April 2024

AbstractIt would be very beneficial to have a method for joining of ceramics to titanium reliably. Although several techniques have been developed and tested to prevent extensive interfacial chemical reactions in titanium‐ceramic systems, the main problem of the inherent brittleness of interfaces was still unsolved. To overcome this problem also in dental applications, we decided to make use of an interlayer material that needs to meet the following requirements: First, it has to be biocompatible, second, it should not melt below the bonding temperatures, and third, it should not react too strongly with titanium, so that its plasticity will be maintained. Considering possible material options only the metals: gold, platinum, palladium, and silver, fulfill the first and second requirements. To find out—without an extensive experimental testing program—which of the four metals fulfills the third requirement best, the combined thermodynamic and reaction kinetic modeling was employed to evaluate how many and how thick reaction layers are formed between the interlayer metals and titanium. With the help of theoretical modeling, it was shown that silver fulfills the last requirement best. However, before starting to test experimentally the effect of the silver layer on the mechanical integrity of dental ceramic/Ag/Ti joints it was decided to make use of mechanical analysis of the three‐point bending test, the result of which indicated that the silver layer increases significantly the bond strength of the joints. This result encouraged us to develop a new technique for plating silver on titanium. Subsequently, we executed numerous three‐point bending tests, which demonstrated that silver‐plated titanium‐ceramic joints are much stronger than conventional titanium‐ceramic joints. Hence, it can be concluded that the combined thermodynamic, reaction kinetic, and mechanical modeling method can also be a very valuable tool in medical research and development work.
A lightweight hybrid model for the automatic recognition of uterine fibroid ultrasound images based on deep learning
Authors: Cai Peiya , Yang Tiantian , Xie Qinglai , Liu Peizhong , Li Ping 
Published: April 2024

AbstractPurposeUterine fibroids (UF) are the most frequent tumors in ladies and can pose an enormous threat to complications, such as miscarriage. The accuracy of prognosis may also be affected by way of doctor inexperience and fatigue, underscoring the want for automatic classification fashions that can analyze UF from a giant wide variety of images.MethodsA hybrid model has been proposed that combines the MobileNetV2 community and deep convolutional generative adversarial networks (DCGAN) into useful resources for medical practitioners in figuring out UF and evaluating its characteristics. Real‐time automated classification of UF can aid in diagnosing the circumstance and minimizing subjective errors. The DCGAN science is utilized for superior statistics augmentation to create first‐rate UF images, which are labeled into UF and non‐uterine‐fibroid (NUF) classes. The MobileNetV2 model then precisely classifies the photos based totally on this data.ResultsThe overall performance of the hybrid model contrasts with different models. The hybrid model achieves a real‐time classification velocity of 40 frames per second (FPS), an accuracy of 97.45%, and an F1 rating of 0.9741.ConclusionBy using this deep learning hybrid approach, we address the shortcomings of the current classification methods of uterine fibroid.
Evaluating the use of HEIghten critical thinking assessment to monitor critical thinking in dental students
Authors: Jauregui Catherine E. , Messer Regina , Vitolo Joseph M. , Young Nancy 
Published: April 2024

AbstractPurpose/ObjectivesCritical thinking and evidence‐based dentistry are skills that dental students are required to demonstrate, but monitoring and quantifying progress can be challenging. This study is investigating whether the HEIghten critical thinking assessment (HCTA) could be used as a potential tool, both for use prior to admitting students, and to monitor whether the students’ skills improve over their time at dental school.MethodsFreshman dental students (n = 92) were given the HCTA during their first semester of dental school. Statistical analyses were then performed to examine the association of Dental Admission Test (DAT) scores (overall, perceptual ability, and total science) and Grade Point Average (GPA) (overall and science) on critical thinking scores (total, analytic, and synthetic).ResultsThere was a significant positive association between GPA, DAT scores and critical thinking scores.ConclusionsOur results indicate that the HCTA may be a useful tool to enable monitoring of students analytical and synthetic skills throughout their time at dental school.
YBX1 promotes stemness and cisplatin insensitivity in intrahepatic cholangiocarcinoma via the AKT/β‐catenin axis
Authors: Shi Xiaodong , Hu Zhiliang , Bai Shilei , Zong Chen , Xue Hui , Li Yao , Li Fengwei , Chen Liangrui , Xuan Jianbing , Xia Yong , Wei Lixin , Shen Feng , Wang Kui 
Published: April 2024

AbstractBackgroundIntrahepatic cholangiocarcinoma (ICC) is a highly aggressive malignancy characterized by a poor prognosis and closely linked to tumor stemness. However, the key molecules that regulate ICC stemness remain elusive. Although Y‐box binding protein 1 (YBX1) negatively affects prognosis in various cancers by enhancing stemness and chemoresistance, its effect on stemness and cisplatin sensitivity in ICC remains unclear.MethodsThree bulk and single‐cell RNA‐seq datasets were analyzed to investigate YBX1 expression in ICC and its association with stemness. Clinical samples and colony/sphere formation assays validated the role of YBX1 in stemness and sensitivity to cisplatin. AZD5363 and KYA1979K explored the interaction of YBX1 with the phosphatidylinositol 3‐kinase (PI3K)/protein kinase B (PKB/AKT) and WNT/β‐catenin pathways.ResultsYBX1 was significantly upregulated in ICC, correlated with worse overall survival and shorter postoperative recurrence time, and was higher in chemotherapy‐non‐responsive ICC tissues. The YBX1‐high group exhibited significantly elevated stemness scores, and genes linked to YBX1 upregulation were enriched in multiple stemness‐related pathways. Moreover, YBX1 expression is significantly correlated with several stemness‐related genes (SOX9, OCT4, CD133, CD44 and EPCAM). Additionally, YBX1 overexpression significantly enhanced the colony‐ and spheroid‐forming abilities of ICC cells, accelerated tumor growth in vivo and reduced their sensitivity to cisplatin. Conversely, the downregulation of YBX1 exerted the opposite effect. The transcriptomic analysis highlighted the link between YBX1 and the PI3K/AKT and WNT/β‐catenin pathways. Further, AZD5363 and KYA1979K were used to clarify that YBX1 promoted ICC stemness through the regulation of the AKT/β‐catenin axis.ConclusionsYBX1 is upregulated in ICC and promotes stemness and cisplatin insensitivity via the AKT/β‐catenin axis. Our study describes a novel potential therapeutic target for improving ICC prognosis.
Deep Learning Model for Grading and Localization of Lumbar Disc Herniation on Magnetic Resonance Imaging
Authors: Xu Yefu , Zheng Shijie , Tian Qingyi , Kou Zhuoyan , Li Wenqing , Xie Xinhui , Wu Xiaotao 
Published: April 2024

BackgroundMethods for grading and localization of lumbar disc herniation (LDH) on MRI are complex, time‐consuming, and subjective. Utilizing deep learning (DL) models as assistance would mitigate such complexities.PurposeTo develop an interpretable DL model capable of grading and localizing LDH.Study TypeRetrospective.Subjects1496 patients (M/F: 783/713) were evaluated, and randomly divided into training (70%), validation (10%), and test (20%) sets.Field Strength/Sequence1.5T MRI for axial T2‐weighted sequences (spin echo).AssessmentThe training set was annotated by three spinal surgeons using the Michigan State University classification to train the DL model. The test set was annotated by a spinal surgery expert (as ground truth labels), and two spinal surgeons (comparison with the trained model). An external test set was employed to evaluate the generalizability of the DL model.Statistical TestsCalculated intersection over union (IoU) for detection consistency, utilized Gwet's AC1 to assess interobserver agreement, and evaluated model performance based on sensitivity and specificity, with statistical significance set at P < 0.05.ResultsThe DL model achieved high detection consistency in both the internal test dataset (grading: mean IoU 0.84, recall 99.6%; localization: IoU 0.82, recall 99.5%) and external test dataset (grading: 0.72, 98.0%; localization: 0.71, 97.6%). For internal testing, the DL model (grading: 0.81; localization: 0.76), Rater 1 (0.88; 0.82), and Rater 2 (0.86; 0.83) demonstrated results highly consistent with the ground truth labels. The overall sensitivity of the DL model was 87.0% for grading and 84.0% for localization, while the specificity was 95.5% and 94.4%. For external testing, the DL model showed an appreciable decrease in consistency (grading: 0.69; localization: 0.66), sensitivity (77.2%; 76.7%), and specificity (92.3%; 91.8%).Data ConclusionThe classification capabilities of the DL model closely resemble those of spinal surgeons. For future improvement, enriching the diversity of cases could enhance the model's generalization.Level of Evidence4.Technical EfficacyStage 2.
Embodied and Enactive Creativity: Moving Beyond the Mind–Body Dichotomy in School Education
Authors: Bertin‐Renoux Anne 
Published: April 2024

ABSTRACTThis study explores the ways in which embodied creativity is conceived and implemented in french schools through the study of a corpus of professional articles published since the 1960s in a journal dedicated to physical education. The analysis focuses on pedagogical experiments to foster bodily creativity carried out in primary schools, as part of a wide‐ranging educational reform during the 1970s. Those practices mark a radical break with the grammar of schooling whose worldwide spread is linked to the colonial expansion of western Europe. They revealed many similarities with indigenous pedagogies through the willingness to go beyond the mind–body dichotomy, to value a sensitive and intuitive body, to anchor knowledge in lived experience and to move from a top‐down relationship between teacher and pupil to a more horizontal one. The 1980s marked a return to more traditional methods, but these pedagogical experiments nurtured a conception of embodied and enactive creativity that sought to go beyond a western vision of the body, of action and of the relationship with the world in school education. The convergences with non‐western pedagogies underline the interest of these approaches to explore and foster embodied and enactive creativity.
Sustainable production of sophorolipid biosurfactants using renewable cellulose‐derived feedstocks
Authors: Msanne Joseph , Ashby Richard D. , Harron Andrew , Czerhoniak Alexis 
Published: April 2024

AbstractGlycolipids produced and secreted by oleaginous yeasts are renewable compounds with important physico‐chemical properties, and multiple biological and industrial applications. The large‐scale production of these compounds has been limited by high production costs and low yields. The sophorolipid‐producing yeast Pseudohyphozyma bogoriensis may possess the ability to grow in fermentation systems using carbon substrates deriving from inexpensive lignocellulosic biomass, while simultaneously secreting high value biomaterials. In this study, comparative analyses between different cellulose‐derived carbon sources including glucose, cellobiose, and sodium carboxymethyl cellulose confirmed the ability of P. bogoriensis to grow and accumulate glycolipids using these substrates. On a dry weight basis, the highest yields of about 4% (wt/wt) glycolipids were obtained when cellobiose was supplemented at 10 g/L in shake‐flask fermentations. When the unconventional carbon substrate sodium carboxymethyl cellulose was supplemented, cultures exhibited a lower glycolipid yield of 0.3% (wt/wt), but the dry weight was higher compared to other substrates. Analytical analyses using various chromatography methods confirmed the chemical profiles, whereas both monoacetylated and diacetylated sophorolipid forms with 22 carbon long‐chain hydroxy fatty acid were identified in all glycolipid extracts. Surface tension (ST) and critical micelle concentration (CMC) measurements showed that glycolipids produced on cellulose‐derived substrates exhibited similar or even superior physical properties compared with glucose. Furthermore, availability of the yeast genome sequences facilitated the identification of putative genes that may be involved in cellulose hydrolysis (e.g., cellulase‐like). Information on genomic and metabolic pathways is a prerequisite for trait improvement toward increasing the production of high value biomaterials.
A Novel Classification System and Surgical Strategies of First Branchial Cleft Anomalies
Authors: Kong Dedi , Li Wei , Zhou Pei , Zhang Yibo , Dai Chunfu 
Published: April 2024

ObjectiveTo define a novel classification of first branchial cleft anomalies (FBCAs) based on the relationship between lesions and the facial nerve in terms of radiographic imaging findings and to introduce the corresponding surgical managements.MethodsThe clinical data were retrospectively reviewed. Novel classification was proposed according to the head–neck MRI findings and surgical records. FBCAs limited in the cartilaginous segment of external auditory canal (EAC) or superficial parotid gland capsule were classified as type A. Lesions close to the FN and(or) involved into the parotid gland with no scar formation and no previous parotidectomy were classified as type B. FBCAs adhered to the FN and(or) invaded the parotid gland with scar formation due to previous surgery were classified as type C. Appropriate surgery approaches was also described, which was correlated with classification.ResultsFifty‐one patients were included, and one patient suffered from bilateral lesions. Thirty‐one, twelve, and nine lesions were classified as type A, type B, and type C FBCAs, respectively. One type A patient (1.92%) suffered from recurrence during follow‐up. Temporary facial palsy (House‐Brackmann II) was identified in 2 type C patients (3.85%) after surgery and recovered to normal within 2 months. One type B patient (1.92%) suffered from facial paralysis due to the FN injury and underwent facial nerve graft simultaneously. No patients with type C complained of hearing loss postoperatively.ConclusionThis novel classification clearly illustrates definitely relationship between lesion and the facial nerve and appropriate surgical strategies were proposed based on the novel classification.Level of Evidence4 Laryngoscope, 134:4246–4251, 2024