bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigating protease-mediated peptides of inflammation and tissue remodeling as biomarkers associated with flares in psoriatic arthritis
Authors: Groen Solveig Skovlund , Nielsen Signe Holm , Bay-Jensen Anne Christine , Rasti Mozhgan , Ganatra Darshini , Oikonomopoulou Katerina , Chandran Vinod 
Published: May 2024

Abstract
Background
Psoriatic arthritis (PsA) is an inflammatory arthritis associated with psoriasis. PsA disease involves flares, which are associated with increased joint inflammation and tissue remodeling. There is a need for identifying biomarkers related to PsA disease activity and flares to improve the management of PsA patients and decrease flares. The tissue turnover imbalance that occurs during the inflammatory and fibro-proliferative processes during flares leads to an increased degradation and/or reorganization of the extracellular matrix (ECM), where increased proteolysis plays a key role. Hence, protease-mediated fragments of inflammatory and tissue-remodeling components could be used as markers reflecting flares in PsA patients.

Methods
A broad panel of protease-mediated biomarkers reflecting inflammation and tissue remodeling was measured in serum and synovial fluid (SF) obtained from PsA patients experiencing flares (acutely swollen joint[s], PsA-flare). In serum, biomarker levels assessed in PsA-flare patients were compared to controls and in early-diagnosed PsA patients not experiencing flares (referred to as PsA without flare). Furthermore, the biomarker levels assessed in SF from PsA-flare patients were compared to the levels in SF of osteoarthritis (OA) patients.

Results
In serum, levels of the PRO-C3 and C3M, reflecting formation and degradation of the interstitial matrix, were found significantly elevated in PsA-flare compared to controls and PsA without flare. The remodeling marker of the basement membrane, PRO-C4, was significantly elevated in PsA-flare compared to PsA without flare. The inflammation and immune cell activity related markers, CRPM, VICM, and CPa9-HNE were significantly elevated in PsA-flare patients compared to controls and PsA without flare. In addition, VICM (AUC = 0.71), CPa9-HNE (AUC = 0.89), CRPM (AUC = 0.76), and PRO-C3 (AUC = 0.86) showed good discriminatory performance for separating PsA-flare from PsA without flare. In SF, the macrophage activity marker, VICM, was significantly elevated whereas the type II collagen formation marker, PRO-C2, was significantly reduced in the PsA-flare compared to OA. The combination of five serum markers reflecting type III and IV collagen degradation (C3M and C4M, respectively), type III and VI collagen formation (PRO-C3 and PRO-C6, respectively), and neutrophil activity (CPa9-HNE) showed an excellent discriminatory performance (AUC = 0.98) for separating PsA-flare from PsA without flares.

Conclusions
The serum biomarker panel of C3M, C4M, PRO-C3, PRO-C6, and CPa9-HNE reflecting synovitis, enthesitis, and neutrophil activity may serve as novel tool for quantitatively monitoring flares in PsA patients.
Peer-to-peer botnets: exploring behavioural characteristics and machine/deep learning-based detection
Authors: Kabla Arkan Hammoodi Hasan , Thamrin Achmad Husni , Anbar Mohammed , Manickam Selvakumar , Karuppayah Shankar 
Published: May 2024

AbstractThe orientation of emerging technologies on the Internet is moving toward decentralisation. Botnets have always been one of the biggest threats to Internet security, and botmasters have adopted the robust concept of decentralisation to develop and improve peer-to-peer botnet tactics. This makes the botnets cleverer and more artful, although bots under the same botnet have symmetrical behaviour, which is what makes them detectable. However, the literature indicates that the last decade has lacked research that explores new behavioural characteristics that could be used to identify peer-to-peer botnets. For the abovementioned reasons, in this study, we propose new two methods to detect peer-to-peer botnets: first, we explored a new set of behavioural characteristics based on network traffic flow analyses that allow network administrators to more easily recognise a botnet’s presence, and second, we developed a new anomaly detection approach by adopting machine-learning and deep-learning techniques that have not yet been leveraged to detect peer-to-peer botnets using only the five-tuple static indicators as selected features. The experimental analyses revealed new and important behavioural characteristics that can be used to identify peer-to-peer botnets, whereas the experimental results for the detection approach showed a high detection accuracy of 99.99% with no false alarms.
Graphical Abstract
Oscillatory criteria of noncanonical even-order differential equations with a superlinear neutral term
Authors: El-Gaber A. A. 
Published: May 2024

AbstractThe oscillatory behavior of solutions of an even-order differential equation with a superlinear neutral term is considered using Riccati and generalized Riccati transformations, the integral averaging technique, and the theory of comparison. New sufficient conditions are established in the noncanonical case. An example is given to support our results.
Demiclosed principle and some fixed-point theorems for generalized nonexpansive mappings in Banach spaces
Authors: Shukla Rahul , Panicker Rekha , Vijayasenan Deepa 
Published: May 2024

AbstractThe aim of this paper is to discuss some results concerning the demiclosedness principle of generalized, nonexpansive mappings in uniformly convex spaces. Further, we present some new fixed-point theorems for generalized nonexpansive mappings in different settings of Banach spaces.
Shaping and shifting schemas on supervised injectable opioid treatment: findings from a cross-sectional qualitative study in two German treatment facilities
Authors: Friedmann Zoe , Kinkel Hans-Tilmann , Kühner Claudia , Zsolnai Andreas , Binder Annette , Mick Inge 
Published: May 2024

Abstract
Background
Supervised injectable opioid treatment (SIOT) is a promising alternative for people living with opioid use disorder (OUD) who have not sufficiently benefitted from oral opioid substitution treatment. Yet, SIOT utilization remains limited in Germany. We propose that this is due to beliefs, or schemas, on SIOT among people living with OUD. Drawing from medical sociology and social psychology, this study explores the emergence and evolution of such schemas on SIOT.

Methods
We conducted semi-structured interviews with 34 individuals currently in or eligible for SIOT in two German outpatient treatment facilities and paralleled an inductive qualitative content analysis with the exploration of individual cases.

Results
The analysis revealed that peer-to-peer interaction and individuals’ practical experiences in therapy are crucial in constructing and changing idiosyncratic and shared schemas of SIOT. When facing ambiguous information, cognitive strategies like subtyping served to mitigate uncertainty.

Conclusion
This research has important practical implications for integrating experiential knowledge into clinical care and improve information sharing among people living with OUD. A nuanced understanding of the complex network of informal advice-seeking and -giving among people living with OUD is indispensable to adequately expand treatment modalities of proven effectiveness.
International collaboration towards innovation management: a network perspective and the Global Innovation Index
Authors: Pepe Clarisse G. E. , Fonseca Marcus V. A. , Silva Marques Christiane F. 
Published: May 2024

AbstractThis article aims to fill an existing knowledge gap within the literature: the characteristics of networks of publication on innovation management research and its relationship with country’s innovativeness. The study is grounded in the theory that the creation of knowledge and collaboration within networks play a pivotal role in improving a nation’s innovation capacity. It presents and describes the characteristics of co-authorship networks of scientific publications among authors from different countries. The published articles were extracted from the Scopus and Web of Science databases, considering a period of 12 years. Following the identification of pivotal countries, the research proceeded to investigate whether their positioning within the network has an impact on their innovation capabilities. To underpin this analysis, data from the Global Innovation Index ranking were employed. Among the six countries demonstrating noteworthy centrality metrics throughout the entire period, Germany, the United States, and the United Kingdom are also categorized as innovators according to the Global Innovation Index. The overlap observed suggests a relationship between countries maintaining consolidated and resilient innovation networks and positive performance in terms of innovation. However, it should be noted that innovation is influenced by a range of factors, including strategies and policies on international collaboration.
Validation of the eating pathology symptoms inventory (EPSI) in Swedish adolescents
Authors: Birgegård Andreas , Isomaa Rasmus , Monell Elin , Bjureberg Johan 
Published: May 2024

Abstract
Background
Eating disorders (ED) are associated with symptoms across body image, disordered eating, and exercise-related domains, and while predominantly affecting females, ED in males is also a significant concern. However, popular self-report methods insufficiently capture male presentations. This study aimed (1) to validate the first Swedish translation of the Eating Pathology Symptoms Inventory (EPSI), which was designed to overcome limitations in previous measures, and (2) compare genders gender-specific manifestations of eating pathology, depression, and anxiety in Swedish high-school students.

Methods
Participants were 359 high-school students (47% males) aged 17.0 years (range 15–21).

Results
Confirmatory factor analysis and correlation patterns showed support for the 8-factor structure and convergent validity, but poorer discriminant validity may suggest caution in interpreting single scales as evidence of ED pathology. Gender comparisons were broadly consistent with previous research.

Conlusions
: The Swedish EPSI may be used to asses ED symptoms, but caution is suggested in interpreting some scales in isolation as indicative of ED pathology.
Development and psychometric validation of a brief scale to measure environmental perception based on the 2-major environmental values model in adolescents and adults
Authors: Randler Christoph , Härtel Talia , de Almeida Barbosa Renan 
Published: May 2024

Abstract
Background
The worldwide ecological crisis, including global climate change, is leading to increased awareness and attitudes towards environmental problems. To address these problems, studies of human attitudes are needed. This study is based on the 2-Major Environmental Values (2-MEV) model, which measures two components of environmental attitudes: Preservation and Utilization. The model has been applied to both, adolescents and adults. After decades of use, it is necessary to review the psychometric scale and update the wording. Developing short or even super-short scales to measure well-established constructs is necessary due to time constraints, compliance or fatigue due to language issues.

Methods
We applied an exploratory factor analysis (EFA) to a dataset containing 20 items from the 2-MEV model to reduce the scale to 6 items, 3 per dimension using parallel analysis, scree plot examination and eigen-value greater than 0 as criteria. The scale was then applied to adults and the sample was split for EFA and confirmatory factor analysis (CFA). Multigroup confirmatory factor analysis (MGCFA) was then used to assess invariance across age and gender. Finally, regression and linear models were used to examine the effects of age and gender in both, adults and adolescents.

Results
The 2-MEV model was replicated in the EFA and CFA and the correlated two-factor model showed the best fit. The scale showed configural and metric invariance across age and gender, and scale invariance across gender. Gender and age effects were replicated in relation to previous studies.

Discussion
The brief scale showed good model indices and convergent validity.

Implications
The brief scale of the 2-MEV model can be applied in situations where environmental attitudes are important, but time constraints (internet surveys), compliance, or language problems may hinder the use of longer scales.
Measurement invariance of the inventory of Callous‑Unemotional traits in different age groups from preschool age to late adolescence in Germany
Authors: Rademacher Annika , Bäker Neele , Eilts Jule , von Düring Ute , Wilke Jessica 
Published: May 2024

Abstract
Background
Callous-unemotional traits are associated with the development of severe behavior problems, delinquency, and psychopathy. Previous studies have repeatedly shown that CU traits may be present as early as preschool age, and they have consistently used the Inventory of Callous-Unemotional Traits (ICU) to assess CU traits in children and adolescents. A three-factor structure for the ICU has been widely endorsed.

Method
The aim of our study is to compare the three-factor structure of the ICU in different age groups (preschool, middle childhood, early, and late adolescence) and to test for measurement invariance in a German sample of N = 2368 children and adolescents (M = 11.76 years; SD = 3.72).

Results
The results of our study indicate configural measurement invariance, suggesting that the ICU has the same structure in all age groups but with different meanings, parameters, and mean values in the groups.

Conclusion
Accordingly, the ICU cannot be applied in the same way to children and adolescents of different age groups, which emphasizes the need for a more differentiated assessment.
Unveiling the veil: exploring how wellbeing motivations shape anonymous and public prosocial behavior in Indonesia
Authors: Yuliawati Livia 
Published: May 2024

AbstractIndonesia is often regarded as a country with a strong inclination toward prosocial behavior, with both public and anonymous acts of kindness being commonplace. However, there is a notable gap in related research regarding the predictors of such behaviors. Previous studies have highlighted how individuals with diverse motives for wellbeing are inclined to either assist or hinder others. The present study explored the role of eudaimonic, hedonic, and extrinsic motives for wellbeing in predicting public and anonymous prosocial behavior. Using convenience sampling, 254 Indonesian undergraduate students (18-25 years old) from a private university participated in an online survey. The data were analyzed with correlational design and structural equation modelling. The findings revealed that the eudaimonic motive for wellbeing positively predicted anonymous prosocial behavior. Interestingly, no significant impact of hedonic motives on either public or anonymous prosocial behavior was observed. On the other hand, the extrinsic motive for wellbeing emerged as a positive predictor of public prosocial behavior. The absence of a discernible effect of the hedonic motive on either form of prosocial behavior highlights the need for further research into the complex interplay between motives for well-being and altruistic actions. This research represents a pioneering exploration into the distinct impacts of individuals' pursuit of wellbeing on their approaches to altruistic actions, providing valuable insights for understanding and promoting prosocial behavior in society.
Hypothesis testing for performance evaluation of probabilistic seasonal rainfall forecasts
Authors: Cheng Ke-Sheng , Yu Gwo‑Hsing , Tai Yuan-Li , Huang Kuo-Chan , Tsai Sheng‑Fu , Wu Dong‑Hong , Lin Yun-Ching , Lee Ching-Teng , Lo Tzu-Ting 
Published: May 2024

AbstractA hypothesis testing approach, based on the theorem of probability integral transformation and the Kolmogorov–Smirnov one-sample test, for performance evaluation of probabilistic seasonal rainfall forecasts is proposed in this study. By considering the probability distribution of monthly rainfalls, the approach transforms the tercile forecast probabilities into a forecast distribution and tests whether the observed data truly come from the forecast distribution. The proposed approach provides not only a quantitative measure for performance evaluation but also a cumulative probability plot for insightful interpretations of forecast characteristics such as overconfident, underconfident, mean-overestimated, and mean-underestimated. The approach has been applied for the performance evaluation of probabilistic season rainfall forecasts in northern Taiwan, and it was found that the forecast performance is seasonal dependent. Probabilistic seasonal rainfall forecasts of the Meiyu season are likely to be overconfident and mean-underestimated, while forecasts of the winter-to-spring season are overconfident. A relatively good forecast performance is observed for the summer season.
DIGITAL RESOURCES AS AN EFFECTIVE MEANS FOR DEVELOPING COMMUNICATIONS SKILLS OF A FUTURE DOCTOR
Authors: Makarova Olga V. , Khvoshch Raisa N. , Boldyreva Yulia V. 
Published: May 2024

Background. This paper presents the experience of introducing the integrated course “Speech aspects of patient-centered communication” into the educational process of medical students. The research relevance is due to the low motivation of students to study linguistic disciplines. However, there is a direct correlation between the level of communication skills developed at language courses and the efficiency in solving professional problems, including those related to the treatment of patients.
Purpose. The paper is aimed at justifying the use of digital resources as an effective means of mastering the skills of communication between a doctor and a patient.
Materials and methods. The material of the study is educating videos, cases designed for visualizing ‘Virtual patient’, digital texts, interactive resources (https://wordwall.net/ru, https://quizlet.com, https://genial.ly, etc.), as well as and the content based on them, i.e., presentations, videos, multimedia materials. The paper uses theoretical and empirical research methods, including discourse analysis and the method of modeling situations “doctor – patient”.
Results. The introduction of digital resources contributes to the conscious developing of the future doctor communication skills and the change in the existing attitude of students to this process from - "I know how to communicate with patients" - to the opinion - “I still have a lot to learn and develop both universal basic patient orientated communication skills (establishing contact, taking anamnesis, completing a consultation) and advanced communication skills of explanation and planning.”
Conclusion. The conditions for mastering the communication skills of a future doctor are as follows: 1) organization of classes based on a collaborative approach involving active learning methods; 2) integration of subject areas, in particular language and medicine; 3) use of digital resources imitating the real working conditions with the patient and allowing you.
NAS BRECHAS DO SISTEMA: DECOLONIALIDADE, COMUNICAÇÃO, MÍDIAS E IDENTIDADE NEGRA
Authors: Cunha Shirlei Alexandra da 
Published: May 2024

A possibilidade de acesso às redes é um traço importante de democratização da comunicação e o ciberespaço é ocupado por inúmeras vozes que até então eram excluídas e invisibilizadas. No mundo físico, o controle dos meios de produção e divulgação de seus produtos ainda se concentra nas mãos de grupos muito bem caracterizados: homens brancos e cisgênero. Conceitos como o colonialismo e a colonialidade do Poder, do Ser e do Saber têm sido importantes aliados nos estudos acadêmicos para explicar essa realidade de inferiorização e de desumanização de pessoas, em especial, os negros. O pacto narcisístico da branquitude perpetua os valores e ideologias de seu grupo e impede os subalternizados de acessar as melhores posições na sociedade. Contudo as transformações políticas, econômicas e educacionais, principalmente as ocorridas nas últimas duas décadas (2000-2020), têm mudado esse cenário. A emancipação pelo acesso à educação e o maior poder aquisitivo da população negra tem modificado o perfil das universidades e tensionando esses espaços pelo questionamento decolonial e ampliando as pesquisas que tratam das especificidades da população negra tendo as vivências desta mesma população. Neste ensaio teórico considera-se que, se no ciberespaço a presença dos corpos negros é uma realidade tangível, já nas emissoras de Tv aberta a presença de protagonistas negros que fujam dos estereótipos que desumanizam e subalternizam seus corpos tem se constituído em mais um dos desafios deste grupo contra o racismo e na direção de uma sociedade mais justa e menos desigual. Daí a importância da convergência das mídias, que, ao inserir programas televisivos nas redes sociais digitais, amplia o escopo dos interlocutores, para além da comunicação síncrona e em tempo real, e para além do território nacional, promovendo, assim, a ampliação da perspectiva de alteridade.
Effect of microalgae (Tetraselmis chui Butcher 1959) on growth and survival of nile tilapia (Oreochromis niloticus Linnaeus 1758) reared in low salinity biofloc system
Authors: Iba Wa , Wahyuni Neneng , Hamzah Muhaimin , Rice Michael A. 
Published: May 2024

Addition of microalgae in the biofloc system may improve growth and survival of Nile tilapia. Also, culturing Nile tilapia in saline water biofloc system may be an adaptation for freshwater shortage. In this study, the growth and survival of Nile tilapia cultured in a low salinity biofloc system with added microalgae was investigated. Increasing salinity in the culture system was done by gradually adding sea water into acclimatization container (618 L, v) on weekly basis for 4 weeks until 9 psu salinity was reached. Tilapia were allowed to adapt to salinity change for one week and fed with commercial feed twice a day until satiation. The biofloc experiment was conducted with 3 microalgal density treatments (5, 15 and 25 × 104 cells. mL-1) in triplicates. Average initial weight of experimental fish was 4.82 ± 0.76 g. Tilapia were reared for 40 days in aquaria (35 × 35 × 40 cm, l × w × h, 15 L, v) containing 8 individuals fish in each aquarium. The commercial pellets were delivered twice per day at 5% of tilapia biomass until satiation. T. chui was added to the tilapia culture every week. This study showed that the addition of microalgae did not affect the fish weight gain, specific growth rate and survival (p0.05). However, feed conversion ratio and culture productivity were better in tilapia supplied with weekly addition of T. chui at 15 × 104 cells mL-1 compared to other densities tested.Keywords:SalineBioflocMicroalgae