bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transcriptional regulation of human FE65, a ligand of Alzheimer's disease amyloid precursor protein, by Sp1
Authors: Yu Hoi‐Tin , Chan William Wai‐Lun , Chai Ka‐Ho , Lee Chris Wing‐Cheung , Chang Raymond Chuen‐Chung , Yu Man‐Shan , McLoughlin Declan M. , Miller Christopher C.J. , Lau Kwok‐Fai 
Published: January 2010

AbstractFE65 is a neuronal‐enriched adaptor protein that binds to the Alzheimer's disease amyloid precursor protein (APP). FE65 forms a transcriptionally active complex with the APP intracellular domain (AICD). The precise gene targets for this complex are unclear but several Alzheimer's disease‐linked genes have been proposed. Additionally, evidence suggests that FE65 influences APP metabolism. The mechanism by which FE65 expression is regulated is as yet unknown. To gain insight into the regulatory mechanism, we cloned a 1.6 kb fragment upstream of the human FE65 gene and found that it possesses particularly strong promoter activity in neurones. To delineate essential regions in the human FE65 promoter, a series of deletion mutants were generated. The minimal FE65 promoter was located between −100 and +5, which contains a functional Sp1 site. Overexpression of the transcription factor Sp1 potentiates the FE65 promoter activity. Conversely, suppression of the FE65 promoter was observed in cells either treated with an Sp1 inhibitor or in which Sp1 was knocked down. Furthermore, reduced levels of Sp1 resulted in downregulation of endogenous FE65 mRNA and protein. These findings reveal that Sp1 plays a crucial role in transcriptional control of the human FE65 gene. J. Cell. Biochem. 109: 782–793, 2010. © 2010 Wiley‐Liss, Inc.
Effect of polyethylene oxide–polyethylene glycol content and humidity on performance of electro‐active paper actuators based on cellulose/polyethylene oxide–polyethylene glycol microcomposite
Authors: Mahadeva Suresha K. , Kim Jaehwan 
Published: January 2010

AbstractThe effect of humidity and polyethylene oxide (PEO)–polyethylene glycol (PEG) content on the actuator performance of cellulose/PEO–PEG microcomposites was studied. Upon blending 5% PEO–PEG, the maximum bending displacement of the actuator increased nearly twice compared to that of cellulose EAPap actuator. However, further increase of PEO–PEG content resulted in decreased actuator performance. This might be due to the increased intermolecular interaction by hydrogen bonding that reduces the mobility of the molecules. The actuator performance test showed that the increase in humidity level rather reduced the maximum displacement of the actuators. X‐ray diffractogram and Fourier transform infrared spectrum analysis suggested a structural change of the microcomposites as well as disruption of cellulose/PEO–PEG association attributed to the actuator performance degradation at high humidity level. POLYM. ENG. SCI., 2010. © 2010 Society of Plastics Engineers
Helix‐sheet packing in proteins
Authors: Hu Chengcheng , Koehl Patrice 
Published: January 2010

AbstractThe three‐dimensional structure of a protein is organized around the packing of its secondary structure elements. Although much is known about the packing geometry observed between α‐helices and between β‐sheets, there has been little progress on characterizing helix–sheet interactions. We present an analysis of the conformation of αβ2 motifs in proteins, corresponding to all occurrences of helices in contact with two strands that are hydrogen bonded. The geometry of the αβ2 motif is characterized by the azimuthal angle θ between the helix axis and an average vector representing the two strands, the elevation angle ψ between the helix axis and the plane containing the two strands, and the distance D between the helix and the strands. We observe that the helix tends to align to the two strands, with a preference for an antiparallel orientation if the two strands are parallel; this preference is diminished for other topologies of the β‐sheet. Side‐chain packing at the interface between the helix and the strands is mostly hydrophobic, with a preference for aliphatic amino acids in the strand and aromatic amino acids in the helix. From the knowledge of the geometry and amino acid propensities of αβ2 motifs in proteins, we have derived different statistical potentials that are shown to be efficient in picking native‐like conformations among a set of non‐native conformations in well‐known decoy datasets. The information on the geometry of αβ2 motifs as well as the related statistical potentials have applications in the field of protein structure prediction. Proteins 2010. © 2010 Wiley‐Liss, Inc.
Effect of acid‐based chemical polish etching on the performance of silicon heterojunction solar cells
Authors: Zhang Yu , Zhou Yuqin , Jiang Zhenyu , Liu Fengzhen , Zhu Meifang 
Published: January 2010

AbstractAn acid‐based chemical polish (CP) was introduced to deal with the c‐Si wafer textured by an alkaline solution. With prolonging the CP etching time (tCP), the average angle of pyramid peak (ϕ) is monotonously increased. It can be well explained by mass‐transfer etching theory. The reduction of the surface roughness and the increasing of ϕ by CP etching improve the coverage and contact between the thin film and the substrate. The effect of CP on the cell's performance was investigated. The CP etching reduces the series resistance (Rs) and enhances the fill factor (FF). The average reflectivity of substrate increases with tCP and reaches to the maximal value of about 13.0% at tCP = 120 s. A long CP etching time shows a negative effect on the short‐circuit current density (Jsc). The micro‐region chemical analysis shows that, with increasing tCP, the Na+ content of substrate decreases effectively. The minority carrier lifetime of the textured substrate and the cell's open‐circuit voltage (Voc) increase with increasing tCP. The above results indicate that adding the acid‐based CP etching to the textured Si wafer is benefited to the performance of salor cells (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Polycrystalline silicon thin films on glass obtained by nickel‐induced crystallization of amorphous silicon
Authors: Schmidt J. A. , Budini N. , Arce R. D. , Buitrago R. H. 
Published: January 2010

AbstractIn this work, we use the nickel‐induced crystallization process to crystallize a‐Si:H thin films at temperatures compatible with the utilization of glass substrates. Hydrogenated amorphous silicon films are deposited on planar float glass (Schott AF37) by plasma‐enhanced chemical vapour deposition. The films, between 400 and 1400 nm thick, are grown intrinsic, slightly p‐doped (p‐) or with a combined structure of heavily p‐doped / slightly p‐doped (p+/p‐) layers. On these films we sputter nickel with concentrations between 2.5×1014 and 3×1015 at./cm2, and then we anneal the samples in a standard nitrogen‐purged tube furnace. The process evolves through the formation of the nickel silicide NiSi2, which has a lattice constant very similar to that of c‐Si and acts as a nucleation centre. As a result of this thermal treatment we obtain thin polycrystalline films with a grain size over 100 μm. The high crystallinity of the samples is confirmed through optical and electron microscopy observations, X‐rays diffraction and Raman spectroscopy. (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Psychological and symptomatic stress‐related disorders with radio‐electric treatment: psychometric evaluation
Authors: Rinaldi Salvatore , Fontani Vania , Aravagli Lucia , Margotti Matteo Lotti 
Published: January 2010

AbstractThe purpose of this study was the evaluation of the effectiveness in the improvement of the psychic and symptomatic stress‐related disorders by means of radio‐electric stimulation on some auricular reflex points with a device named the radio‐electric asymmetric conveyer (REAC). This study was conducted on 124 subjects with psychological distress symptoms that were assessed by the Symptomatic Check List‐90 (SCL‐90) pre‐ and post‐intervention. After randomization, two groups were created: a group treated with effective REAC and a group that underwent the same treatment with disarmed REAC (the placebo group). There was a significant reduction in SCL‐90 scores in the treated group compared with the placebo group. The results of the psychometric tests showed that the subjects who underwent effective therapy showed a statistically significant (p < 0.05) reduction in their level of stress and psychological disorders compared with the control group. The reduction of the levels of perceived stress and the reduction of the psychic and symptomatic stress‐related disorders assessed by SCL‐90 tests, obtained after one cycle of reflex auricular protocol REAC treatment, showed that this treatment can be useful in the cure of psychological stress‐related symptoms. Copyright © 2009 John Wiley & Sons, Ltd.
Physical self‐concept and social physique anxiety: invariance across culture, gender and age
Authors: Hagger Martin S. , Stevenson Andy , Chatzisarantis Nikos L. D. , Gaspar Pedro Miguel Pereira , Ferreira José Pedro Leitão , Ravé José María González 
Published: January 2010

AbstractThis study examined the effects of culture, gender and age on the structure and mean levels of physical self‐concept (PSC) and social physique anxiety (SPA) in adolescents from Portugal and Spain. An additional aim was to examine the effects of these variables on the PSC‐SPA correlation. Adolescents (N = 3528, age range 12–18 years) completed the social physique anxiety scale and physical self‐worth scale from the physical self‐perception profile. Single‐ and multi‐sample confirmatory factor analyses supported a two‐factor model of PSC and SPA in the overall sample and within and across the culture, gender and age subsamples. Latent means analyses indicated that females tended to have significantly higher average SPA levels and lower PSC levels relative to males. There was a general downward trend in PSC in males and females in each cultural group. SPA was relatively consistent in females and higher than males in most groups. SPA was relatively similar in males and females in younger age groups (born 1994–1996), but declined in older males. SPA was similar in Portuguese males and females in the youngest age group (born 1996), but males tended to have lower scores in older age groups. Results generally support hypotheses and are discussed relative to self‐presentation models and coping with appearance‐related stress. Copyright © 2010 John Wiley & Sons, Ltd.
Culture‐general and ‐specific associations of attachment avoidance and anxiety with perceived parental warmth and psychological control among Turk and Belgian adolescents☆
Authors: Güngör Derya , Bornstein Marc H. 
Published: January 2010

ABSTRACTBoth the adolescent peer attachment and perceived parenting style literatures emphasize the role of the quality of the parent–child relationship in children's healthy adjustment beyond the family, but few studies have investigated links between adolescents' peer attachment and perceptions of parenting. We investigate relations of adolescents' perceptions of warmth and psychological control from parents with avoidance and anxiety in attachment to close friends in two contrasting cultures. Altogether, 262 Turk and 263 Belgian youth between 14 and 18 years of age participated. Cross‐culturally, attachment avoidance was negatively related to maternal warmth, and attachment anxiety positively related to maternal and paternal control and negatively to paternal warmth. Beyond these general relations, attachment avoidance was associated with paternal psychological control in Belgians but not in Turks. The study provides cross‐cultural evidence for specific relations between peer attachment and perceived parenting and suggests a culture‐specific pathway for the development of attachment avoidance.
Engagement in adolescent career preparation: Social support, personality and the development of choice decidedness and congruence
Authors: Hirschi Andreas , Niles Spencer G. , Akos Patrick 
Published: January 2010

ABSTRACTThis longitudinal panel study investigated predictors and outcomes of active engagement in career preparation among 349 Swiss adolescents from the beginning to the end of eighth grade. Latent variable structural equation modeling was applied. The results showed that engagement in terms of self‐ and environmental‐exploration and active career planning related positively to interindividual increases in career decidedness and choice congruence. More perceived social support, early goal decidedness, and particular personality traits predicted more engagement. Support and personality impacted outcomes only mediated through engagement. Early decidedness and congruence were significant predictors of their respective later levels. Implications for practice are presented.
The cartography of pain: The evolving contribution of pain maps
Authors: Schott Geoffrey D. 
Published: January 2010

AbstractPain maps are nowadays widely used in clinical practice. This article aims to critically review the fundamental principles that underlie the mapping of pain, to analyse the evolving iconography of pain maps and their sometimes straightforward and sometimes contentious nature when used in the clinic, and to draw attention to some more recent developments in mapping pain. It is concluded that these maps are intriguing and evolving cartographic tools which can be used for depicting not only the spatial features but also the interpretative or perceptual components and accompaniments of pain.
Magnetic resonance imaging of guinea pig cochlea after vasopressin‐induced or surgically induced endolymphatic hydrops
Authors: Marshall Allen F. , Jewells Valerie L. , Kranz Peter , Lee Yeuh Z. , Lin Weili , Zdanski Carlton J. 
Published: January 2010

ObjectiveTo investigate the ability to detect the in vivo cochlear changes associated with vasopressin‐induced and surgically induced endolymphatic hydrops using MRI at 3 tesla (T).Study DesignProspective, animal model.SettingAnimal laboratory.Subjects and MethodsIn group 1, five guinea pigs underwent post–gadolinium temporal bone MRI before and after seven and 14 days of chronic systemic administration of vasopressin by osmotic pump. In group 2, five guinea pigs underwent temporal bone MRI eight weeks after unilateral surgical ablation of the endolymphatic sac. Three‐tesla high‐resolution T1‐weighted sequences were acquired pre‐ and postcontrast administration. Region of interest signal intensities of the perilymph and endolymph were analyzed manually. Quantitative evaluation of hydrops was measured histologically.ResultsGadolinium preferentially concentrated in the perilymph, allowing for distinction of cochlear compartments on 3.0‐T MRI. The T1‐weighted contrast MRI of vasopressin‐induced hydropic cochlea showed significant increases in signal intensity of the endolymph and perilymph. Surgically induced unilateral hydropic cochlea also showed increased signal intensity, compared with the control cochlea of the same animal, but less of an increase than the vasopressin group. The histological degree of hydrops induced in the vasopressin group was comparable to previous studies.ConclusionsIn vivo postcontrast MRI of the inner ear demonstrated cochlear changes associated with chronic systemic administration of vasopressin and surgical ablation of the endolymphatic sac. Understanding the MRI appearance of endolymphatic hydrops induced by various methods contributes to the future use of MRI as a possible tool in the diagnosis and treatment of Ménière's disease.
Keratocystic odontogenic tumor associated with nevoid basal cell carcinoma syndrome: Similar behavior to sporadic type?
Authors: Figueroa Adriana , Correnti Maria , Avila Maira , Andea Aleodor , DeVilliers Patricia , Rivera Helen 
Published: January 2010

ObjectiveThe objective of this study was to analyze the expression of proliferative markers and p53 in keratocystic odontogenic tumor (KCOT) sporadic type and KCOT associated with nevoid basal cell carcinoma syndrome (NBCCS).Study Design and SettingWe performed a cross‐sectional study. A total of 19 patients with KCOT were selected from the Oral Pathology Laboratory archives, Central University of Venezuela, from 1995 to 2005.Subjects and MethodsTwelve cases corresponded to sporadic KCOT, and seven cases were associated with NBCCS. Immunohistochemical analysis for p53, proliferating cell nuclear antigen (PCNA), and Ki‐67 was performed in all 19 cases.ResultsOf the seven cases associated with NBCCS, six (86%) were positive for PCNA. From the 12 sporadic cases, nine (75%) were positive for PCNA. Only one case of sporadic KCOT showed Ki‐67 positivity. Five of 12 (42%) cases of sporadic KCOT were positive for p53, and only one (14%) case associated with NBCCS was positive for p53.ConclusionOn the basis of the analysis of the expression of PCNA, Ki‐67, and p53, there appears to be no evidence to indicate higher aggressiveness in growth and infiltrative behavior in syndromic KCOT compared with the sporadic type. Therefore, surgical treatment may be approached in the same manner in KCOT sporadic and syndromic with the goal of minimizing recurrence.
Clinical course of arteriovenous malformations of the head and neck: A case series
Authors: Richter Gresham T. , Suen James Y. 
Published: January 2010

ObjectiveTo demonstrate, in a case series, the relentless growth of arteriovenous malformations (AVMs) of the head and neck and the importance of their vigilant management within the context of a modified staging system.Study DesignRetrospective review.SettingTertiary care institution, Vascular Anomalies Center.Subjects and MethodsSubjects were patients with advanced AVMs presenting to our Vascular Anomalies Center. Medical records were examined for age at first diagnosis, disease course, prior treatments, age at presentation, management, therapeutic outcomes, stage of disease, and impact on quality of life. Early patient photographs were evaluated.ResultsTen patients (ages 13‐46 yrs) with extensive cervicofacial AVMs were examined. Progressive growth, worsening symptoms, and graduated disease stage were universally experienced by each patient, as evident by serial photographs, over a course of many years. Each patient presented to our institution with massive lesions, bleeding, pain, and facial destruction. Prior embolization and/or surgery had been performed in all but one patient. Every patient had been previously told that their AVMs were incurable or that treatment options were exhausted. The patients were subsequently treated at our institution with surgical resection with or without preoperative embolization. Disease control, symptom improvement, and enhanced daily functioning were attained in each patient.ConclusionThe natural course of AVMs is progressive, invasive, and destructive. Vigilant observation, early treatment, and radical therapy are necessary for AVMs of the head and neck.
Time of cochlear implant surgery in academic settings
Authors: Majdani Omid , Schuman Theodore A. , Haynes David S. , Dietrich Mary S. , Leinung Martin , Lenarz Thomas , Labadie Robert F. 
Published: January 2010

ObjectiveEstablish the time required to perform cochlear implantation (CI) in academic settings.Study DesignHistorical cohort study.SettingGerman and American academic centers.PatientsA total of 2639 patients underwent CI (1997‐2007). We excluded patients receiving an experimental device or technique and those with abnormal cochlear anatomy or incomplete charts, leaving 2253 for analysis.InterventionUnilateral, bilateral, and revision CI with devices approved in the U.S. and Europe.Main Outcome MeasuresMean surgical time (ST) and total operating room time (TORT).ResultsMixed model analysis was used; estimated marginal means were calculated in minutes after adjusting for random effect of individual surgeon. There were no differences between unilateral (ST = 171, TORT = 245) and revision CI (ST = 160, TORT = 232), but bilateral procedures were longer (ST = 295, TORT = 377, P < 0.001). In unilateral surgeries, Cochlear Limited (CL) devices were implanted faster (ST = 165, TORT = 225) than Advanced Bionics (ABC) (ST = 183, P = 0.001; TORT = 240, P = 0.023) or MedEl (ST = 193, P < 0.001; TORT = 253, P = 0.002) devices. There were no differences for unilateral CI between ABC and MedEl devices. For revision CI, ABC devices (ST = 141, TORT = 219) were implanted faster than CL devices (ST = 181, P = 0.001; TORT = 266, P < 0.001). There were no differences by age group or between Germany and the U.S. ST and TORT were shorter for 575 CIs performed in the final two years of the study (unilateral CI: ST = 145, TORT = 209; bilateral CI: ST = 259, TORT = 330; revision CI: ST = 138, TORT = 205). For unilateral CI, ST and TORT decreased yearly (linear regression, P < 0.001) and inversely correlated with surgeon experience (linear regression, P < 0.01).ConclusionsWe report the time required to perform CI in academic settings—data that are vital for cost‐benefit analyses and assessing new CI techniques.
Clinical assessment of adenoidal obstruction based on the nasal obstruction index is no longer useful in children
Authors: Marchisio Paola , Torretta Sara , Capaccio Pasquale , Esposito Susanna , Dusi Elisa , Nazzari Erica , Bossi Anna , Pignataro Lorenzo , Principi Nicola 
Published: January 2010

ObjectiveTo evaluate the accuracy of clinical assessment of adenoidal obstruction based on a standardized score of the degree of mouth breathing and speech hyponasality (nasal obstruction index [NOI]) in comparison to nasal fiberoptic endoscopy.Study DesignCross‐sectional study with planned data collection.SettingOutpatient clinics of the Departments of Maternal and Pediatric Sciences and Specialized Surgical Sciences, University of Milan, Italy.Subjects and MethodsChildren aged three to 12 years with adenoidal obstruction suspected on the grounds of persistent/recurrent otitis media or perceived obstructive nasal breathing were eligible. Ear, nose, and throat examination, allergy testing, NOI measurement, and nasal fiberoptic endoscopy to assess the degree of adenoidal hypertrophy were performed. Agreement between the NOI and adenoidal hypertrophy grade was assessed in the patients as a whole and by clinical subgroups.ResultsA total of 202 children were enrolled: 54.9 percent had otological diseases and 45.1 percent had perceived obstructive nasal breathing. Most of the children (79.2%) showed mild or moderate clinical nasal obstruction. Adenoidal hypertrophy ranged from no obstruction (18%) to severe obstruction (38%). There was no substantial agreement between the NOI and the degree of adenoidal obstruction in the population as a whole and in all the clinical subgroups. False positive findings were significantly more frequent among allergic children (50%) than non‐allergic children (22.4%, P = 0.009).ConclusionClinical assessment based on the NOI is incapable of accurately predicting the degree of adenoidal obstruction. In children with clinical nasal obstruction not explainable by adenoidal size, the clinician should consider, among causes of more anterior obstruction, nasal allergy.