bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Survey‐Based Evaluation of Logistics and Transportation Research Journal Quality
Authors: Gorman Michael F. , Kanet John J. 
Published: October 2011

AbstractWe administered a survey of authors who conduct transportation research and have recently published in transportation‐related research journals. The purpose of the survey was to assess the authors’ perceptions of the quality of journals that publish transportation research. We used lists of journals that were included in previous surveys of logistics‐focused researchers. We note that transportation‐related journals cater to a wide audience of researcher disciplines and practitioners. Evaluations of logistics‐related journals have been conducted in the past, but none have surveyed the full community of transportation researchers and journals. In this study 320 such researchers rated 21 journals. For this sample, Transportation Research B was found to be most highly regarded, followed closely by Transportation Science. Following these were Transportation Research A, Journal of Transport Economics and Policy, Naval Research Logistics, Transportation Research C, and Journal of Business Logistics.
A Fibre-Reinforced Fixed Partial Denture on a Hemisectioned Tooth: A Case Report
Authors: AGÜLOĞLU Süleyman , AYNA Emrah , ÖZDEMİR Eylem 
Published: October 2011

In modern dentistry, fibre-reinforced fixed dental prostheses are considered a useful alternative to classical metal-ceramic restorations. This method allows a conservative approach for replacing missing teeth that overcomes some of the drawbacks of conventional prostheses. Our patient required extraction of tooth #46 because of an apical lesion of the mesial root, and underwent extraction by hemisection. After healing, using the superior properties of the combined fibre/composite, an adhesive bridge restoration was applied with support from the distal root of tooth #46 and teeth #45 and #47.
How to cite this article: Agüloğlu S, Ayna E, Özdemir E. A Fibre-Reinforced fixed partial denture on a hemisectioned tooth: A Case Report. Int Dent Res 2011;1:38-41.
Linguistic Revision: The English in this manuscript has been checked by at least two professional editors, both native speakers of English.
Active Enzyme Nanocoatings Affect Settlement of Balanus amphitrite Barnacle Cyprids
Authors: Tasso Mariana , Conlan Sheelagh L. , Clare Anthony S. , Werner Carsten 
Published: October 2011

AbstractBalanus amphitrite cyprids produce complex adhesive substances that enable their attachment to surfaces and impart a strong detachment resistance from most immersed substrata. The colonization of man‐made structures by barnacle cyprids and other marine organisms is a troublesome and costly phenomenon, for which controlling strategies are actively sought. In this work, we expand previous investigations about the susceptibility of cyprid adhesives to unpurified proteases in solution by evaluating the interplay between these secreted biomolecules and a surface‐confined purified protease. The strategy involved the covalent immobilization of the enzyme Subtilisin A to maleic anhydride copolymer thin films through the spontaneous reaction of anhydride moieties with lysine side chains. This enabled the production of bioactive layers of tunable enzyme surface concentration and activity, which were utilized to systematically evaluate the effect of the immobilized enzyme on cyprid settlement and exploratory behavior. Surfaces of increasing enzyme activity displayed a gradual decrease in cyprid settlement levels (approaching inhibition) as well as an increase in post‐settlement adhesion failure (evidenced by significant numbers of detached metamorphosed individuals). High activities of the bound enzyme also affected pre‐settlement behavior of cyprids, reducing the velocity and total distance moved while increasing the amount and speed of meander compared to the controls. The here‐reported low enzyme surface concentrations found to be remarkably effective at reducing cyprid settlement hold promise for the use of immobilized enzymes in the control of marine biofouling.
Mesoporous Anatase Titania Hollow Nanostructures though Silica‐Protected Calcination
Authors: Joo Ji Bong , Zhang Qiao , Lee Ilkeun , Dahl Michael , Zaera Francisco , Yin Yadong 
Published: October 2011

AbstractThe crystallization of nanometer‐scale materials during high‐temperature calcination can be controlled by a thin layer of surface coating. Here, a novel silica‐protected calcination process for preparing mesoporous hollow TiO2 nanostructures with a high surface area and a controllable crystallinity is presented. This method involves the preparation of uniform silica colloidal templates, sequential deposition of TiO2 and then SiO2 layers through sol–gel processes, calcination to transform amorphous TiO2 to crystalline anatase, and finally etching of the inner and outer silica to produce mesoporous anatase TiO2 shells. The silica‐protected calcination step allows crystallization of the amorphous TiO2 layer into anatase nanocrystals, while simultaneously limiting the growth of anatase grains to within several nanometers, eventually producing mesoporous anatase shells with a high surface area (∼311 m2 g−1) and good water dispersibility upon chemical etching of the silica. When used as photocatalysts for the degradation of Rhodamine B under UV irradiation, the as‐synthesized mesoporous anatase shells show significantly enhanced photocatalytic activity with greater enhancement for samples calcined at higher temperatures thanks to their improved crystallinity.
Craniofacial and oral features of Sotos syndrome: Differences in patients with submicroscopic deletion and mutation of NSD1 gene
Authors: Hirai Norimitsu , Matsune Kensuke , Ohashi Hirofumi 
Published: October 2011

AbstractSotos syndrome is a well‐known overgrowth syndrome caused by haploinsufficiency of NSD1 gene located at 5q35. There are two types of mutations that cause NSD1 haploinsufficiency: mutations within the NSD1 gene (mutation type) and a 5q35 submicroscopic deletion encompassing the entire NSD1 gene (deletion type). We investigated detailed craniofacial, dental, and oral findings in five patients with deletion type, and three patients with mutation type Sotos syndrome. All eight patients had a high palate, excessive tooth wear, crowding, and all but one patient had hypodontia and deep bite. Hypodontia was exclusively observed in the second premolars, and there were no differences between the deletion and mutation types in the number of missing teeth. Another feature frequently seen in common with both types was maxillary recession. Findings seen more frequently and more pronounced in deletion‐type than in mutation‐type included mandibular recession, scissors or posterior cross bite, and small dental arch with labioclination of the maxillary central incisors. It is noteworthy that although either scissors bite or cross bite was present in all of the deletion‐type patients, neither of these was observed in mutation‐type patients. Other features seen in a few patients include enamel hypoplasia (two deletion patients), and ectopic tooth eruption (one deletion and one mutation patients). Our study suggests that Sotos syndrome patients should be observed closely for possible dental and oral complications especially for malocculusion in the deletion‐type patients. © 2011 Wiley Periodicals, Inc.
Clinical manifestations and management of four children with Pearson syndrome
Authors: Tumino Manuela , Meli Concetta , Farruggia Piero , La Spina Milena , Faraci Maura , Castana Cinzia , Di Raimondo Vincenzo , Alfano Marivana , Pittalà Annarita , Lo Nigro Luca , Russo Giovanna , Di Cataldo Andrea 
Published: October 2011

AbstractPearson marrow‐pancreas syndrome is a fatal disorder mostly diagnosed during infancy and caused by mutations of mitochondrial DNA. We hereby report on four children affected by Pearson syndrome with hematological disorders at onset. The disease was fatal to three of them and the fourth one, who received hematopoietic stem cell transplantation, died of secondary malignancy. In this latter patient transplantation corrected hematological and non‐hematological issues like metabolic acidosis, and we therefore argue that it could be considered as a useful option in an early stage of the disease. © 2011 Wiley Periodicals, Inc.
Robust optimal control of time‐delay systems based on Razumikhin theorem
Authors: Chuang Chia‐Hua , Lin Chun‐Liang , Lin Yu‐Chen 
Published: October 2011

AbstractThis paper presents an optimal control approach for the general robust control design problem of linear time delay systems, which considers parameter uncertainties as well as state delay. It is shown that the robust control problem can be transformed into an optimal control problem with the amouof plant uncertainties involved in the performance index. A stability criterion has been developed under which the uncertain dynamical system can not only achieve stability, but also acquire the guaranteed level of performance for regulation. A suitable linear state feedback control law is also characterized via Lyapunov stability theory to ensure performance robustness of the closed‐loop system.Copyright © 2011 John Wiley and Sons Asia Pte Ltd and Chinese Automatic Control Society
Effect of pulsed electromagnetic field exposure on adenosine receptors in rat brain
Authors: Varani Katia , Vincenzi Fabrizio , Targa Martina , Corciulo Carmen , Fini Milena , Setti Stefania , Cadossi Ruggero , Borea Pier Andrea 
Published: October 2011

AbstractDifferent effects of pulsed electromagnetic field (PEMF) exposure on brain tissue have been described in pre‐clinical models and in clinical settings. Nevertheless, the mechanism of action and the possible interaction with membrane receptors such as adenosine receptors (ARs) has not been investigated. The present study focused on the effect of PEMFs on A1 and A2A ARs in the rat cerebral cortex and cortical neurons. Affinity and density of ARs were evaluated by means of saturation binding experiments while mRNA expression was investigated through retro‐transcription polymerase chain reaction (RT‐PCR). PEMF treatment of the intact rat cerebral cortex or cortical neurons at 1.5 mT mediated a transient and significant increase in A2A ARs after 4 h (2.0‐fold increase) and 6 h (1.4‐ and 1.8‐fold increase, respectively) of exposure. In addition, PEMF treatment of the rat cerebral cortex and rat cortical neurons at 3 mT upregulated A2A ARs after 2 h (2.0‐ and 2.2‐fold increase, respectively) and 4 h (1.6‐ and 1.9‐fold increase, respectively). The treatment of rat cortex membranes with PEMFs at 1.5 and 3 mT induced an increase in A2A AR density after 2 h (1.9‐ and 2.2‐fold increase, respectively) and was constant at all incubation times investigated. In rat cortical neurons, mRNA levels of A1 and A2A ARs were not affected by PEMF exposure for the times and intensities used. These results suggest that PEMF treatment has different biological effects in whole organs or cells in comparison with isolated membranes. Bioelectromagnetics 33:279–287, 2012. © 2011 Wiley Periodicals, Inc.
Effects of direct electric current on Herpetomonas samuelpessoai: An ultrastructural study
Authors: Gomes Marina das Neves , Teixeira Cesar Augusto Antunes , Barbosa Gleyce Moreno , Froes Marcela Teso , Silva Maria Bernadete , da Veiga Venicio Feo , Soares Rosangela Maria de Araújo , dos Santos André Luis Souza , Holandino Carla 
Published: October 2011

AbstractThe literature shows that the effects of direct electric currents on biological material are numerous, including bactericidal, fungicidal, parasiticidal, and anti‐tumoral, among others. Non‐pathogenic trypanosomatids, such as Herpetomonas samuelpessoai, have emerged as important models for the study of basic biological processes performed by a eukaryotic cell. The present study reports a dose‐dependent anti‐protozoan effect of direct electric treatment with both cathodic and anodic current flows on H. samuelpessoai cells. The damaging effects can be attributable to the electrolysis products generated during electric stimulation. The pH of the cell suspension was progressively augmented from 7.4 to 10.5 after the cathodic treatment. In contrast, the anodic treatment caused a pH decrease varying from 7.4 to 6.5. Transmission electron microscopy analyses revealed profound alterations in vital cellular structures (e.g., mitochondrion, kinetoplast, flagellum, flagellar pocket, nucleus, and plasma membrane) after exposure to both cathodic and anodic current flows. Specifically, cathodic current flow treatment induced the appearance of autophagic‐like structures on parasite cells, while those submitted to an anodic current flow presented marked disorganization of plasma membrane and necrotic appearance. However, parasites treated in the intermediary chamber (without contact with the electrodes) did not present significant changes in viability or morphology, and no pH variation was detected in this system. The use of H. samuelpessoai as a biological model and the direct electric current experimental approach used in our study provide important information for understanding the mechanisms involved in the cytotoxic effects of this physical agent. Bioelectromagnetics 33:334–345, 2012. © 2011 Wiley Periodicals, Inc.
Extraction of lignins from aqueous–ionic liquid mixtures by organic solvents
Authors: Xin Qin , Pfeiffer Katie , Prausnitz John M. , Clark Douglas S. , Blanch Harvey W. 
Published: October 2011

AbstractThe commercial development of ionic liquids (ILs) to pretreat lignocellulose by dissolution of whole biomass and cellulose precipitation by addition of water is hindered by the absence of an effective technique to recover the lignin content of the biomass from the IL. Three organic solvents [ethyl acetate, 1,4‐dioxane, and tetrahydrofuran (THF)] were studied for their ability to form a two‐liquid‐phase system with water and 1‐ethyl‐3‐methylimidazolium acetate ([C2mim][OAc]), and for partitioning model lignins and lignin monomers between the two liquid phases. Ternary diagrams were obtained for three [C2mim][OAc]/organic solvent/water systems at 22°C. Partition coefficients were measured for several types of lignin in these three systems. Partition coefficients increase with rising water content in the IL phase, and depend strongly on the type of lignin and on the organic solvent. Partition coefficients rise as the pH of the ionic‐liquid‐rich phase falls. Small molecule model lignin monomer compounds (guaiacol, syringaldehyde) are also readily extracted from the IL/water system by THF. Biotechnol. Bioeng. 2012; 109:346–352. © 2011 Wiley Periodicals, Inc.
Acetate enhances startup of a H2‐producing microbial biocathode
Authors: Jeremiasse Adriaan W. , Hamelers Hubertus V.M. , Croese Elsemiek , Buisman Cees J.N. 
Published: October 2011

AbstractH2 can be produced from organic matter with a microbial electrolysis cell (MEC). To decrease MEC capital costs, a cathode is needed that is made of low‐cost material and produces H2 at high rate. A microbial biocathode is a low‐cost candidate, but suffers from a long startup and a low H2 production rate. In this study, the effects of cathode potential and carbon source on microbial biocathode startup were investigated. Application of a more negative cathode potential did not decrease the startup time of the biocathode. If acetate instead of bicarbonate was used as carbon source, the biocathode started up more than two times faster. The faster startup was likely caused by a higher biomass yield for acetate than for bicarbonate, which was supported by thermodynamic calculations. To increase the H2 production rate, a flow through biocathode fed with acetate was investigated. This biocathode produced 2.2 m3 H2 m−3 reactor day−1 at a cathode potential of −0.7 V versus NHE, which was seven times that of a parallel flow biocathode of a previous study. Biotechnol. Bioeng. 2012; 109:657–664. © 2011 Wiley Periodicals, Inc.
Large eddy simulation of mechanical mixing in anaerobic digesters
Authors: Wu Binxin 
Published: October 2011

AbstractA comprehensive study of anaerobic digestion requires an advanced turbulence model technique to accurately predict mixing flow patterns because the digestion process that involves mass transfer between anaerobes and their substrates is primarily dependent on detailed information about the fine structure of turbulence in the digesters. This study presents a large eddy simulation (LES) of mechanical agitation of non‐Newtonian fluids in anaerobic digesters, in which the sliding mesh method is used to characterize the impeller rotation. The three subgrid scale (SGS) models investigated are: (i) Smagorinsky–Lilly model, (ii) wall‐adapting local eddy‐viscosity model, and (iii) kinetic energy transport (KET) model. The simulation results show that the three SGS models produce very similar flow fields. A comparison of the simulated and measured axial velocities indicates that the LES profile shapes are in general agreement with the experimental data but they differ markedly in velocity magnitudes. A check of impeller power and flow numbers demonstrates that all the SGS models give excellent predictions, with the KET model performing the best. Moreover, the performance of six Reynolds‐averaged Navier–Stokes turbulence models are assessed and compared with the LES results. Biotechnol. Bioeng. 2012; 109:804–812. © 2011 Wiley Periodicals, Inc.
Zonal rate model for stacked membrane chromatography part II: Characterizing ion‐exchange membrane chromatography under protein retention conditions
Authors: Francis Patrick , von Lieres Eric , Haynes Charles 
Published: October 2011

AbstractThe Zonal Rate Model (ZRM) has previously been shown to accurately account for contributions to elution band broadening, including external flow nonidealities and radial concentration gradients, in ion‐exchange membrane (IEXM) chromatography systems operated under nonbinding conditions. Here, we extend the ZRM to analyze and model the behavior of retained proteins by introducing terms for intra‐column mass transfer resistances and intrinsic binding kinetics. Breakthrough curve (BTC) data from a scaled‐down anion‐exchange membrane chromatography module using ovalbumin as a model protein were collected at flow rates ranging from 1.5 to 20 mL min−1. Through its careful accounting of transport nonidealities within and external to the membrane stack, the ZRM is shown to provide a useful framework for characterizing putative protein binding mechanisms and models, for predicting BTCs and complex elution behavior, including the common observation that the dynamic binding capacity can increase with linear velocity in IEXM systems, and for simulating and scaling separations using IEXM chromatography. Global fitting of model parameters is used to evaluate the performance of the Langmuir, bi‐Langmuir, steric mass action (SMA), and spreading‐type protein binding models in either correlating or fundamentally describing BTC data. When combined with the ZRM, the bi‐Langmuir, and SMA models match the chromatography data, but require physically unrealistic regressed model parameters to do so. In contrast, for this system a spreading‐type model is shown to accurately predict column performance while also providing a realistic fundamental explanation for observed trends, including an observed increase in dynamic binding capacity with flow rate. Biotechnol. Bioeng. 2012; 109:615–629. © 2011 Wiley Periodicals, Inc.
Effects of biaxial oscillatory shear stress on endothelial cell proliferation and morphology
Authors: Chakraborty Amlan , Chakraborty Sutirtha , Jala Venkatakrishna R. , Haribabu Bodduluri , Sharp M. Keith , Berson R. Eric 
Published: October 2011

AbstractWall shear stress (WSS) on anchored cells affects their responses, including cell proliferation and morphology. In this study, the effects of the directionality of pulsatile WSS on endothelial cell proliferation and morphology were investigated for cells grown in a Petri dish orbiting on a shaker platform. Time and location dependent WSS was determined by computational fluid dynamics (CFD). At low orbital speed (50 rpm), WSS was shown to be uniform (0–1 dyne/cm2) across the bottom of the dish, while at higher orbital speed (100 and 150 rpm), WSS remained fairly uniform near the center and fluctuated significantly (0–9 dyne/cm2) near the side walls of the dish. Since WSS on the bottom of the dish is two‐dimensional, a new directional oscillatory shear index (DOSI) was developed to quantify the directionality of oscillating shear. DOSI approached zero for biaxial oscillatory shear of equal magnitudes near the center and approached one for uniaxial pulsatile shear near the wall, where large tangential WSS dominated a much smaller radial component. Near the center (low DOSI), more, smaller and less elongated cells grew, whereas larger cells with greater elongation were observed in the more uniaxial oscillatory shear (high DOSI) near the periphery of the dish. Further, cells aligned with the direction of the largest component of shear but were randomly oriented in low magnitude biaxial shear. Statistical analyses of the individual and interacting effects of multiple factors (DOSI, shear magnitudes and orbital speeds) showed that DOSI significantly affected all the responses, indicating that directionality is an important determinant of cellular responses. Biotechnol. Bioeng. 2012; 109:695–707. © 2011 Wiley Periodicals, Inc.
Modulation of the Biological Activity of microRNA‐210 with Peptide Nucleic Acids (PNAs)
Authors: Fabbri Enrica , Manicardi Alex , Tedeschi Tullia , Sforza Stefano , Bianchi Nicoletta , Brognara Eleonora , Finotti Alessia , Breveglieri Giulia , Borgatti Monica , Corradini Roberto , Marchelli Rosangela , Gambari Roberto 
Published: October 2011

AbstractHerein we describe the activity of a peptide nucleic acid (PNA) that targets microRNA‐210 (miR‐210), which is associated with hypoxia and is modulated during erythroid differentiation. PNAs directed against miR‐210 were designed to bind with high affinity to the target RNA strand and to undergo efficient uptake in target cells. A polyarginine–PNA conjugate directed against miR‐210 (Rpep‐PNA‐a210) showed both very high affinity for RNA and efficient uptake into target cells without the need for transfection reagents. An unmodified PNA of the same sequence displayed the ability to bind RNA, but cellular uptake was very poor. Consistent with this, only Rpep‐PNA‐a210 strongly inhibited miR‐210 activity, as evaluated by assays on undifferentiated K562 cells and on cells treated with mithramycin, which was found to induce erythroid differentiation and miR‐210 overexpression. Targeting miR‐210 by Rpep‐PNA‐a210 resulted in: 1) a decrease in miR‐210 levels as measured by RT‐PCR, 2) up‐regulation of raptor mRNA, 3) a decrease in γ‐globin mRNA, and 4) decreased expression of differentiated functions (i.e., proportion of benzidine‐positive cells, content of embryo‐fetal hemoglobins). The efficient delivery of anti‐miR PNAs through a suitable peptide carrier (Rpep‐PNA‐a210) leads to the inhibition of miR‐210 activity, altering the expression of miR‐210‐regulated erythroid functions.