bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enantioselective Allylboration of Acetylene: A Versatile Tool for the Stereodivergent Synthesis of Natural Products
Authors: Álvarez‐Constantino Andrés M. , Chaves‐Pouso Andrea , Fañanás‐Mastral Martín 
Published: June 2024

AbstractEfficient catalytic methods that allow the use of simple and abundant chemical feedstocks for the preparation of synthetically versatile compounds are central to modern synthetic chemistry. Acetylene is a basic feedstock with a remarkable production over one million tons per year, although it is underutilized in the stereoselective synthesis of fine chemicals. Here we report a facile catalytic multicomponent reaction that allows for the enantio‐ and diastereoselective allylboration of acetylene gas. This process is catalyzed by a chiral copper catalyst, operates without specialized equipment or pressurization, and provides chiral skipped dienes bearing stereodefined and orthogonally functionalized olefins with excellent levels of chemo‐, regio‐, enantio‐ and diastereoselectivity. The combined stereochemical features and orthogonal functionalization make the products privileged structural scaffolds to access the complete set of stereoisomers of the chiral skipped diene core through simple enantio‐ and diastereodivergent pathways. The utility of the method is demonstrated with the enantioselective synthesis of three bioactive natural skipped diene products, namely (+)‐Nyasol, (+)‐Hinokiresinol and Phorbasin C, and other related synthetically relevant chiral molecules.
Efficient Silver(I)‐Containing I–Motif DNA Hybrid Catalyst for Enantioselective Diels–Alder Reactions
Authors: Dong Xingchen , Qiu Ziyang , Wang Zixiao , Li Jiaqi , Qin Weijun , Dang Jingshuang , Zhou Wenqin , Jia Guoqing , Chen Yashao , Wang Changhao 
Published: June 2024

AbstractThe inherent chiral structures of DNA serve as attractive scaffolds to construct DNA hybrid catalysts for valuable enantioselective transformations. Duplex and G‐quadruplex DNA‐based enantioselective catalysis has made great progress, yet novel design strategies of DNA hybrid catalysts are highly demanding and atomistic analysis of active centers is still challenging. DNA i‐motif structures could be finely tuned by different cytosine‐cytosine base pairs, providing a new platform to design DNA catalysts. Herein, we found that a human telomeric i‐motif DNA containing cytosine‐silver(I)‐cytosine (C‐Ag+‐C) base pairs interacting with Cu(II) ions (i‐motif DNA(Ag+)/Cu2+) could catalyze Diels–Alder reactions with full conversions and up to 95 % enantiomeric excess. As characterized by various physicochemical techniques, the presence of Ag+ is proved to replace the protons in hemiprotonated cytosine‐cytosine (C : C+) base pairs and stabilize the DNA i‐motif to allow the acceptance of Cu(II) ions. The i‐motif DNA(Ag+)/Cu2+ catalyst shows about 8‐fold rate acceleration compared with DNA and Cu2+. Based on DNA mutation experiments, thermodynamic studies and density function theory calculations, the catalytic center of Cu(II) ion is proposed to be located in a specific loop region via binding to one nitrogen‐7 atom of an unpaired adenine and two phosphate‐oxygen atoms from nearby deoxythymidine monophosphate and deoxyadenosine monophosphate, respectively.
Remarkable Second Harmonic Generation Response in (C5H6NO)+(CH3SO3)−: Unraveling the Role of Hydrogen Bond in Thermal Driven Nonlinear Optical Switch
Authors: Zhang Zi‐Peng , Liu Xin , Wang Rui‐Xi , Zhao Shuang , He Wen‐Jie , Chen Hong‐Yu , Deng Xue‐Bin , Wu Li‐Ming , Zhou Zhengyang , Chen Ling 
Published: June 2024

AbstractHeat‐activated second harmonic generation (SHG) switching materials are gaining interest for their ability to switch between SHG on and off states, offering potential in optoelectronic applications. The novel nonlinear optical (NLO) switch, (C5H6NO)+(CH3SO3)− (4‐hydroxypyridinium methylsulfonate, 4HPMS), is a near‐room‐temperature thermal driven material with a strong SHG response (3.3 × KDP), making it one of the most potent heat‐stimulated NLO switches. It offers excellent contrast of 13 and a high laser‐induced damage threshold (2.5 × KDP), with reversibility > 5 cycles. At 73 °C, 4HPMS transitions from the noncentrosymmetric Pna21 room temperature phase (RTP) to the centrosymmetric P21/c phase, caused by the rotation of the (C5H6NO)+ and (CH3SO3)− due to partially thermal breaking of intermolecular hydrogen bonds. The reverse phase change exhibits a large 50 °C thermal hysteresis. Density functional theory (DFT) calculations show that (C5H6NO)+ primarily dictates both the SHG coefficient (dij) and birefringence (▵n(Zeiss) = 0.216 vs ▵n(cal.) = 0.202 at 546 nm; Δn(Immersion) = 0.210 vs ▵n(cal.) = 0.198 at 589.3 nm), while the band gap (Eg) is influenced synergistically by (C5H6NO)+ and (CH3SO3)−. Additionally, 4HPMS‐RTP also exhibits mechanochromism upon grinding as well as an aggregation‐enhanced emission in a mixture of acetone and water.
Using MXene as a Chemically Induced Initiator to Construct High‐Performance Cathodes for Aqueous Zinc‐Ion Batteries
Authors: Chen Jie , Liu Yanpeng , Xiao Baoquan , Huang Juanjuan , Chen Hongwei , Zhu Kun , Zhang Junkai , Cao Guozhong , He Guanjie , Ma Jing , Peng Shanglong 
Published: June 2024

AbstractMXene usually exhibits weak pseudo‐capacitance behavior in aqueous zinc‐ion batteries, which cannot provide sufficient reversible capacity, resulting in the decline of overall capacity when used as the cathode materials. Taking inspiration from polymer electrolyte engineering, we have conceptualized an in situ induced growth strategy based on MXene materials. Herein, 5.25 % MXene was introduced into the nucleation and growth process of vanadium oxide (HVO), providing the heterogeneous nucleation site and serving as an initiator to regulate the morphology and structural of vanadium oxide (T‐HVO). The resulted materials can significantly improve the capacity and rate performance of zinc‐ion batteries. The growth mechanism of T‐HVO was demonstrated by both characterizations and DFT simulations, and the improved performance was systematically investigated through a series of in situ experiments related to dynamic analysis steps. Finally, the evaluation and comparison of various defect introduction strategies revealed the efficient, safety, and high production output characteristics of the in situ induced growth strategy. This work proposes the concept of in situ induced growth strategy and discloses the induced chemical mechanism of MXene materials, which will aid the understanding, development, and application of cathode in aqueous zinc‐ion batteries.
Ultrasonic weldability of thick and heavier nonwoven fabrics
Authors: Kara Sukran 
Published: June 2024

AbstractNonwovens have wide application areas due to their advantageous properties like low cost, high production efficiency, and tuneable properties. They are mostly used for disposable products. Combining bicomponent fiber spinning with hydroentanglement method is one of the innovative methods to obtain nonwovens for durable applications. On the other hand, ultrasonic welding is an alternative assembling method for disposable products made of low weight nonwovens. In this study, the ultrasonic weldability of relatively heavier weight and thicker nonwoven fabrics made of polyester: polyamide bicomponent microfilaments were examined in order to combine the advantages of nonwovens and ultrasonic welding. Relatively higher thickness and weight, and also fiber composition of the nonwoven fabrics were compelling effects of the study that drove the motivation. Overall 60 samples were produced using five nonwoven fabrics with varying unit masses and 12 selected ultrasonic welding types. Seam strength and strain assessments were supported with stereomicroscope and visual inspections in evaluating the welds. Results showed that despite having thick seam lines up to 1.6 mm, successful welded seams could be obtained. Depending on the welding parameters, seam lines of some samples exhibited waviness, color changes, and deformations but these situations did not drastically affect the seam strength of samples.
Combined effect of montmorillonite Cloisite 30B and graphene nanoplatelets on high‐density polyethylene matrix under high strain rate dynamic compression
Authors: Grison Vagner , Romanzini Daiane , Dias Rafael R. , Pereira Iaci M. , Zattera Ademir J. , Piazza Diego 
Published: June 2024

AbstractLaminated polymer composites are widely used in ballistic barriers where polyethylene can be applied. The mechanical properties of polymers can be improved with the addition of nanofillers. Therefore, this work evaluates the effect of the combination of montmorillonite Cloisite 30B (OMt) and graphene (Gr) on the dynamics compression properties obtained from a split‐Hopkinson pressure bar (SHPB) test for nanostructured maleinized high‐density polyethylene (HDPE). The nanofillers are incorporated into the polymeric matrix in its molten state, and their dispersion is evaluated through x‐ray diffraction and transmission electron microscopy analyses. Thermal analysis, including differential scanning calorimetry and thermogravimetric analysis are performed. Additionally, the viscoelastic behavior of the materials is studied from the results of storage and loss modulus obtained by dynamic‐mechanical analysis. Under the SHPB test conditions, it is possible to evaluate the material stress–strain curve, identifying its yield point, compressive strength, and deformations to calculate the elastic stiffness and toughness of the material. The nanocomposite with 3% OMt and 0.75% Gr (wt.%) shows the highest average compressive strength and toughness values. Furthermore, this sample shows similar Tpeak temperature, improved crystallinity index, storage, and loss modulus, with similar glass transition temperature compared to the HDPE sample.
Gender‐inclusive financial and demographic literacy: Monetizing the gender mortality gap
Authors: Apicella Giovanna , De Giorgi Enrico , Di Lorenzo Emilia , Sibillo Marilena 
Published: June 2024

AbstractLongevity crucially affects demand for pensions, insurance products and annuities. Consistent empirical evidence shows that women have historically experienced lower mortality rates than men. In this article, we study a measure of the gender gap in mortality rates, we call “Gender Gap Ratio”, across a wide range of ages and for four countries: France, Italy, Sweden, and USA. We show the stylized facts that characterize the trend of the Gender Gap Ratio, both in its historical evolution and future projection. Focusing on an example temporary life annuity contract, we give a monetary consistency to the Gender Gap Ratio. We show evidence that a Gender Gap Ratio that ranges between 1.5 and 2.5, depending on age, translates into a significant reduction of up to 23% in the benefits from a temporary life annuity contract for women with respect to men, against the same amount invested in the life annuity. The empirical evidence discussed in this article documents the crucial importance of working toward a more widespread demographic literacy, for example, a range of tools and strategies to raise longevity consciousness among individuals and policy‐makers, in the framework of gender equality policies.
Die Digitalisierung der Prüfung des Standsicherheitsnachweises
Authors: Achenbach Marcus , Weber Beatrix , Rivas Paul 
Published: June 2024

AbstractDie Einführung des digitalen Bauantragsverfahrens ermöglicht, die Prüfung des Standsicherheitsnachweises vollständig papierlos durchzuführen. Dadurch können sowohl statische Berechnung als auch Konstruktionspläne medienbruchfrei geprüft werden, weshalb eine Beschleunigung des Verfahrens erwartet werden kann. Der Übergang von Papier zu PDF stellt einen deutlichen Fortschritt für die beteiligten Parteien dar, kann aber hinsichtlich des Grads der Digitalisierung nur ein Anfang sein. Der größtmögliche Grad der Digitalisierung wird durch die Verwendung von BIM (BIM: Building Information Modeling) in Verbindung mit den notwendigen Datenumgebungen (CDE) erreicht. Da der Einsatz von BIM bei Planung, Errichtung und Betrieb von Gebäuden erhebliche Vorteile bietet, ist die weitere Verbreitung absehbar bzw. wird von der Bundes‐ und den Landesregierungen die Anwendung teilweise bereits vorgeschrieben. Auswirkungen auf die Prüfung und Genehmigung von Bauwerken sind daher zu erwarten. In diesem Aufsatz wird untersucht, wie digitalisierte Prüfprozesse gestaltet werden können. Die Prozesse werden vorgestellt und hinsichtlich des Reifegrads der Digitalisierung bewertet.
Comparative investigation of tellurium‐doped transition metal nanoparticles (Zn, Sn, Mn): Unveiling their superior photocatalytic and antibacterial activity
Authors: Umar Misbah , Ajaz Humayun , Javed Mohsin , Bahadur Ali , Iqbal Shahid , Mahmood Sajid , Sarwar Afifa , Alotaibi Khalid M. , Alshalwi Matar 
Published: June 2024

AbstractIn this study, tellurium‐doped and undoped metal oxide nanoparticles (NPs) (ZnO, Mn3O4, SnO2) are compared, and a practical method for their synthesis is presented. Nanocomposites were created using the coprecipitation process, and comparisons between the three material categories under study were made using a range of characterization methods. The produced materials were subjected to structural, morphological, elemental composition, and functional group analyses using XRD, FESEM in combination with EDS, and FTIR. The optical characteristics in terms of cutoff wavelength were evaluated using UV–visible spectroscopy. Catalyzing the breakdown of methylene blue (MB) dye, the isolated nanocomposites demonstrated very consistent behavior when utilized as catalysts. Regarding both doped and undoped ZnO NPs, the maximum percentage of degradation was found to be 98% when exposed to solar Escherichia coli and Staphylococcus aureus, which stand for gram‐positive and gram‐negative bacteria, respectively, and were chosen as model strains for both groups using the disk diffusion technique in the context of in vitro antibacterial testing. Doped and undoped ZnO NPs exhibited greater antibacterial efficacy, with significant inhibition zones measuring 31.5 and 37.8 mm, compared with other metal oxide NPs.
Chemiluminescence data modeling using parallel factor analysis for the simple and sensitive determination of diphenoxylate in human plasma and tablets
Authors: Koohsarian Maryam , Mokhtari Ali , Hooshmand Shabnam 
Published: June 2024

AbstractIn this study, a chemiluminescence (CL) method was developed to determine diphenoxylate in tablets and human plasma. This is the first CL method proposed to determine diphenoxylate. Creating three‐dimensional data caused the parallel factor analysis algorithm (PARAFAC) to be used for the first time in CL methods. The method is based on the fact that diphenoxylate enhances the weak CL produced in the reaction of Ru(phen)32+ and acidic Ce(IV), and the concentration of Ce(IV) solution has a different effect on the CL response of diphenoxylate and the blank plasma. The calibration curve was linear from 4.0 × 10−8 to 1.6 × 10−6 mol L−1 (R2 = 0.9954), and the detection limit was 1.3 × 10−8 mol L−1 (S/N = 3). The sampling rate was about 30 samples per hour, and the % RSD for 10 repeated measurements of 4 × 10−7 mol L−1 diphenoxylate was 5.4%. The interference effects of some ions, amino acids, and common additives were also investigated. The CL method was successfully used to determine diphenoxylate in tablets, and the results were statistically confirmed by the reference method. The proposed CL method and the PARAFAC algorithm were successfully used to determine the concentration of diphenoxylate in human blood plasma samples.
Chromogenic fusion proteins as alternative textiles dyes
Authors: Watkins Tyson , Moffitt Kaylee , Speight Robert E. , Navone Laura 
Published: June 2024

AbstractThe widespread adoption of fast fashion has led to a significant waste problem associated with discarded textiles. Using proteins to color textiles can serve as a sustainable alternative to chemical dyes as well as reduce the demand for new raw materials. Here, we explore the use of chromogenic fusion proteins, consisting of a chromoprotein and a carbohydrate‐binding module (CBM), as coloring agents for cellulose‐based textiles such as cotton. We examined the color properties of chromoproteins AeBlue, SpisPink and Ultramarine alone and fused to CBM under various conditions. AeBlue, SpisPink and Ultramarine exhibited visible color between pH 4‐9 and temperatures ranging from 4 to 45℃. Fusing CBM Clos from Clostridium thermocellum and CBM Ch2 from Trichoderma reesei to the chromoproteins had no effect on the chromoprotein color properties. Furthermore, binding assays showed that chromoprotein fusions did not affect binding of CBMs to cellulosic materials. Cotton samples bound with Ultramarine‐Clos exhibited visible purple color that faded progressively over time as the samples dried. Applying 10% 8000 polyethylene glycol to cotton samples markedly preserved the color over extended periods. Overall, this work highlights the potential of chromoprotein‐CBM fusions for textile dying which could be applied as a color maintenance technology or for reversible coloring of textiles for events or work wear, contributing to sustainable practices and introducing new creative opportunities for the industry.
Upper end of the central canal of the human spinal cord: Quantitative anatomical study and 3D modeling
Authors: Lefevre Etienne , Quang Megane Le , Chotard Guillaume , Knafo Steven , Mengelle Pierre , Taupin Yanis , Liguoro Dominique , Jecko Vincent , Vignes Jean‐Rodolphe , Roblot Paul 
Published: June 2024

AbstractThe upper end of the central canal of the human spinal cord has been repeatedly implicated in the pathogenesis of various diseases, yet its precise normal position in the medulla oblongata and upper cervical spinal cord remains unclear. The purpose of this study is to describe the anatomy of the upper end of the central canal with quantitative measurements and a three‐dimensional (3D) model. Seven formalin‐embalmed human brainstems were included, and the central canal was identified in serial axial histological sections using epithelial membrane antigen antibody staining. Measurements included the distances between the central canal (CC) and the anterior medullary fissure (AMF) and the posterior medullary sulcus (PMS). The surface and perimeter of the CC and the spinal cord were calculated, and its anterior–posterior and maximum lateral lengths were measured for 3D modeling. The upper end of the CC was identified in six specimens, extending from the apertura canalis centralis (ACC) to its final position in the cervical cord. Positioned on the midline, it reaches its final location approximately 15 mm below the obex. No specimen showed canal dilatation, focal stenosis, or evidence of syringomyelia. At 21 mm under the ACC in the cervical cord, the median distance from the CC to the AMF was 3.14 (2.54–3.15) mm and from the CC to the PMS was 5.19 (4.52–5.43) mm, with a progressive shift from the posterior limit to the anterior third of the cervical spinal cord. The median area of the CC was consistently less than 0.1 mm2. The upper end of the CC originates at the ACC, in the posterior part of the MO, and reaches its normal position in the anterior third of the cervical spinal cord less than 2 cm below the obex. Establishing the normal position of the upper end of this canal is crucial for understanding its possible involvement in cranio‐cervical junction pathologies.
A novel method to manage a dislodged self‐expanding transcatheter aortic valve
Authors: Qureshi Waqas , Walker Jennifer , Mina George , Kakouros Nikolaos 
Published: June 2024

AbstractDespite advancements in technology, operator experience, and procedural planning, transcatheter aortic valve replacement (TAVR) procedures are complex, and complications remain inevitable. Valve embolization may prove to be fatal and conventional rescue techniques are dependent on the anatomy of the aorta. We describe a case of postimplant embolization of a self‐expanding valve during valve‐in‐valve application where the valve could not be stabilized due to the anatomy of the aorta and a novel technique was utilized to stabilize the valve in the aortic arch using a wire fixed to the left axillary artery.
Percutaneous intervention of a giant native coronary artery aneurysm using self‐expanding stents
Authors: Chaturvedi Abhishek , Haberman Dan , Waksman Ron , Bernardo Nelson L. 
Published: June 2024

AbstractIn the absence of standardized management guidelines, coronary artery aneurysms (CAAs) present therapeutic challenges. Percutaneous coronary intervention (PCI) is rarely explored, especially in giant aneurysms with persistent angina, where surgery might be presumed as a preferred option. We describe the technical aspects and feasibility of PCI using Gore Viabahn expanded polytetrafluoroethylene (ePTFE)‐covered nitinol self‐expanding stents in a 66‐year‐old woman with a complex medical history and an enlarging, symptomatic right coronary artery aneurysm. The case was complicated by endoleak after the first stent, but intravascular ultrasound guidance enabled the precise deployment of additional stents, resulting in the successful exclusion of the aneurysm. This case demonstrates steps to successful CAA PCI with Gore Viabahn ePTFE‐covered nitinol self‐expanding stents and emphasizes that in unsuitable surgical candidates, PCI might be a potential alternative for symptomatic CAAs.
Immune checkpoint inhibitor‐induced myasthenia gravis, myocarditis, and myositis: A case report
Authors: Basnet Arjun , Sharma Nava Raj , Gautam Sudarshan , Lamichhane Saral , Kansakar Sajog , Tiwari Kripa , Pokhrel Madalasa , Singh Sehajpreet 
Published: June 2024

Key Clinical MessageImmune checkpoint inhibitors can rarely lead to occurrence of myositis, myocarditis, and myasthenia gravis (MG). Early recognition and multidisciplinary management are crucial for optimal outcomes. Vigilance for overlapping toxicities is essential in patients receiving combination immunotherapy.AbstractThe use of immune checkpoint inhibitors (ICIs) has revolutionized cancer treatment, but it is associated with immune‐related adverse events (IRAEs) affecting various organ systems. The simultaneous occurrence of MG, myocarditis, and myositis highlights the complex nature of IRAEs. Early recognition and comprehensive multidisciplinary management are crucial for optimal patient outcomes. We present a unique case report of a 76‐year‐old male patient with advanced melanoma who developed concurrent myositis, myocarditis, and MG while receiving combination immunotherapy with Nivolumab and Ipilimumab. This case underscores the significance of recognizing and addressing the “Terrible Triad” of IRAEs in patients receiving ICIs. Healthcare providers should maintain a high index of suspicion for overlapping toxicities and promptly initiate appropriate interventions.