bluuebunny/crossref_metadata_2025_split huggingface dataset:
DeepSS2GO: protein function prediction from secondary structure
Authors: Song Fu V , Su Jiaqi , Huang Sixing , Zhang Neng , Li Kaiyue , Ni Ming , Liao Maofu 
Published: May 2024

Abstract
Predicting protein function is crucial for understanding biological life processes, preventing diseases and developing new drug targets. In recent years, methods based on sequence, structure and biological networks for protein function annotation have been extensively researched. Although obtaining a protein in three-dimensional structure through experimental or computational methods enhances the accuracy of function prediction, the sheer volume of proteins sequenced by high-throughput technologies presents a significant challenge. To address this issue, we introduce a deep neural network model DeepSS2GO (Secondary Structure to Gene Ontology). It is a predictor incorporating secondary structure features along with primary sequence and homology information. The algorithm expertly combines the speed of sequence-based information with the accuracy of structure-based features while streamlining the redundant data in primary sequences and bypassing the time-consuming challenges of tertiary structure analysis. The results show that the prediction performance surpasses state-of-the-art algorithms. It has the ability to predict key functions by effectively utilizing secondary structure information, rather than broadly predicting general Gene Ontology terms. Additionally, DeepSS2GO predicts five times faster than advanced algorithms, making it highly applicable to massive sequencing data. The source code and trained models are available at https://github.com/orca233/DeepSS2GO.
Connectome reorganization associated with temporal lobe pathology and its surgical resection
Authors: Larivière Sara , Park Bo-yong , Royer Jessica , DeKraker Jordan , Ngo Alexander , Sahlas Ella , Chen Judy , Rodríguez-Cruces Raúl , Weng Yifei , Frauscher Birgit , Liu Ruoting , Wang Zhengge , Shafiei Golia , Mišić Bratislav , Bernasconi Andrea , Bernasconi Neda , Fox Michael D , Zhang Zhiqiang , Bernhardt Boris C 
Published: May 2024

Abstract
Network neuroscience offers a unique framework to understand the organizational principles of the human brain. Despite recent progress, our understanding of how the brain is modulated by focal lesions remains incomplete. Resection of the temporal lobe is the most effective treatment to control seizures in pharmaco-resistant temporal lobe epilepsy (TLE), making this syndrome a powerful model to study lesional effects on network organization in young and middle-aged adults. Here, we assessed the downstream consequences of a focal lesion and its surgical resection on the brain’s structural connectome, and explored how this reorganization relates to clinical variables at the individual patient level.
We included adults with pharmaco-resistant TLE (n = 37) who underwent anterior temporal lobectomy between two imaging time points, as well as age- and sex-matched healthy controls who underwent comparable imaging (n = 31). Core to our analysis was the projection of high-dimensional structural connectome data—derived from diffusion MRI tractography from each subject—into lower-dimensional gradients. We then compared connectome gradients in patients relative to controls before surgery, tracked surgically-induced connectome reconfiguration from pre- to postoperative time points, and examined associations to patient-specific clinical and imaging phenotypes.
Before surgery, individuals with TLE presented with marked connectome changes in bilateral temporo-parietal regions, reflecting an increased segregation of the ipsilateral anterior temporal lobe from the rest of the brain. Surgery-induced connectome reorganization was localized to this temporo-parietal subnetwork, but primarily involved postoperative integration of contralateral regions with the rest of the brain. Using a partial least-squares analysis, we uncovered a latent clinical imaging signature underlying this pre- to postoperative connectome reorganization, showing that patients who displayed postoperative integration in bilateral fronto-occipital cortices also had greater preoperative ipsilateral hippocampal atrophy, lower seizure frequency and secondarily generalized seizures.
Our results bridge the effects of focal brain lesions and their surgical resections with large-scale network reorganization and interindividual clinical variability, thus offering new avenues to examine the fundamental malleability of the human brain.
Hippocampal excitation-inhibition balance underlies the 5-HT2C receptor in modulating depressive behaviours
Authors: Shi Hu-Jiang , Xue Yi-Ren , Shao Hua , Wei Cheng , Liu Ting , He Jie , Yang Yu-Hao , Wang Hong-Mei , Li Na , Ren Si-Qiang , Chang Lei , Wang Zhen , Zhu Li-Juan 
Published: May 2024

Abstract
The implication of 5-hydroxytryptamine 2C receptor (5-HT2CR) activity in depression is a topic of debate, and the underlying mechanisms remain largely unclear. Here, we elucidate how hippocampal excitation-inhibition (E/I) balance underlies the regulatory effects of 5-HT2CR in depression.
Molecular biological analyses showed that chronic mild stress (CMS) reduced the expression of 5-HT2CR in hippocampus. We revealed that inhibition of 5-HT2CR induced depressive-like behaviours, reduced GABA release and shifted the E/I balance towards excitation in CA3 pyramidal neurons using behavioural analyses, microdialysis coupled with mass spectrometry and electrophysiological recordings. Moreover, 5-HT2CR modulated the neuronal nitric oxide synthase (nNOS)-carboxy-terminal PDZ ligand of nNOS (CAPON) interaction by influencing intracellular Ca2+ release, as determined by fibre photometry and coimmunoprecipitation. Notably, disruption of nNOS-CAPON with the specific small molecule compound ZLc-002 or AAV-CMV-CAPON-125C-GFP abolished 5-HT2CR inhibition-induced depressive-like behaviours, as well as the impairment in soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex assembly-mediated GABA vesicle release and consequent E/I imbalance. Importantly, optogenetic inhibition of CA3 GABAergic neurons prevented the effects of AAV-CMV-CAPON-125C-GFP on depressive behaviours in the presence of a 5-HT2CR antagonist.
Conclusively, our findings disclose the regulatory role of 5-HT2CR in depressive-like behaviours and highlight hippocampal nNOS-CAPON coupling-triggered E/I imbalance as a pivotal cellular event underpinning the behavioural consequences of 5-HT2CR inhibition.
Detached From Humanity: Artificial Gestation and the Christian Dilemma
Authors: Rodger Daniel , Blackshaw Bruce P 
Published: May 2024

Abstract
The development of artificial womb technology (AWT) is continuing to proceed and raises important ethical and theological questions for Christians. While there has been extensive secular discourse on artificial wombs in recent years, there has been minimal Christian engagement with this topic. There are broadly two primary uses of artificial womb technology: first, ectogestation, which is a form of enhanced neonatal care, where only some of the gestation period takes place in an artificial womb, and second, ectogenesis, where the entire period of gestation occurs in an artificial womb. It is plausible that some form of ectogestation in the latter weeks or months of pregnancy could be possible within a decade or so, while ectogenesis for humans remains far more speculative. Ectogestation is likely to significantly reduce maternal and neonatal morbidity and mortality, and so there is a strong prima facie case for supporting its development. Ectogenesis, however, may bring several challenges, including the further commodification of children, and the potential pathologizing of pregnancy and childbirth. Its long-term effects on those created through this process are also unknown. If it becomes ubiquitous, we may also find the central theological significance of pregnancy and birth diminished. The dilemma for Christians is that the development of seemingly unproblematic ectogestation is likely to normalize the use of artificial gestation, and, in time, pave the way for ectogenesis.
Factors influencing farmers’ adoption of solar water-pumping systems in Gujarat
Authors: Sathish Kumar M , Lad Y A , Pundir R S 
Published: May 2024

Abstract
Agriculture has played an important role in the growth of the Indian economy. Water and electricity are essential inputs for agriculture today. India produces the third-largest amount of electricity in the world, behind China and the USA. As an incentive to increase production, most states provide free electricity to farmers. Free electricity has decreased groundwater levels and increased electricity consumption. The objective of this study was to find out the factors that influenced farmers to adopt a solar water-pumping system in Gujarat. The samples were randomly selected. This study examined the entire state of Gujarat. One hundred and fifty farmers who adopted solar water-pumping systems were interviewed, including 50 banana farmers, 50 cotton farmers and 50 groundnut farmers. Primary data were collected through an interview. The adoption of solar water-pumping systems by farmers was identified using factor analysis. SPSS software was used to analyse the data collected. In this study, only two factors contributed to the variance of 59.469%. The adoption of solar water pumps by farmers was influenced by government policy and economic benefits. An economic benefit variance of 33.20% was found, while a government policy variance was 26.27%. A solar water-pumping system has low initial costs, flexible credit policies motivate adoption, solar water-pumping systems can save electricity, and maintenance and repair costs are affordable. Government policy that includes solar water-pumping systems is motivated by awareness, subsidies for adoption and a fair price to sell energy surpluses. Farmers are recommended to adopt a solar water-pumping system in conjunction with a drip irrigation system to receive additional income. The successful scheme will be recommended to other states in India for implementation.
Techno–economic and environmental impact analysis of electric two-wheeler batteries in India
Authors: Gupta Aman , Bose Ditipriya , Tiwari Sandeep , Sharma Vikrant , Prakash Jai 
Published: May 2024

Abstract
This paper presents a comprehensive techno–economic and environmental impact analysis of electric two-wheeler batteries in India. The technical comparison reveals that sodium-ion (Na-ion) and lithium-ion (Li-ion) batteries outperform lead–acid batteries in various parameters, with Na-ion and Li-ion batteries exhibiting higher energy densities, higher power densities, longer cycle lives, faster charge rates, better compactness, lighter weight and lower self-discharge rates. In economic comparison, Na-ion batteries were found to be ~12–14% more expensive than Li-ion batteries. However, the longer lifespans and higher energy densities of Na-ion and Li-ion batteries can offset their higher costs through improved performance and long-term savings. Lead–acid batteries have the highest environmental impact, while Li-ion batteries demonstrate better environmental performance and potential for recycling. Na-ion batteries offer promising environmental advantages with their abundance, lower cost and lower toxic and hazardous material content. Efficient recycling processes can further enhance the environmental benefits of Na-ion batteries. Overall, this research examines the potential of Na-ion batteries as a cheaper alternative to Li-ion batteries, considering India’s abundant sodium resources in regions such as Rajasthan, Chhattisgarh, Jharkhand and others.
Anomaly Metrics on Class Variations For Face Anti-Spoofing
Authors: Liu Weihua , Gong Bing , Che Kai , Ma Jieming , Pan Yushan 
Published: May 2024

Abstract
In face anti-spoofing tasks, distinguishing between live and spoof faces across different data domains presents challenges due to inter-class similarities, intra-class variations and unknown spoof patterns. This hampers generalization in real-world applications. To address this, we propose a novel convolutional neural network framework that utilizes spatial-frequency cues for 2D and 3D attacks. Furthermore, we introduce compact anomaly metrics and design three anomaly metrics-based supervisions from the perspective of Reed-Xiaoli anomaly detection, aiming to tackle the challenge posed by unknown attacks. Thanks to our proposed spatial frequency factorization network and its frequency-related supervisions, the spoofing cues are significantly enhanced, resulting in remarkable improvements in our experimental results. These outcomes demonstrate that our proposed framework achieves state-of-the-art performance on both monocular and multi-spectral benchmark datasets.
In the Name of Mazu: The Use of Religion by China to Intervene in Taiwanese Elections
Authors: Sher Chien-Yuan , Pien Chung-Pei , O'Reilly Colin , Liu Yu-Hsi 
Published: May 2024

Abstract
Foreign policy objectives can be achieved through religious institutions as a form of soft power. However, empirical evidence on this form of soft power is limited. In this study, we provide rigorous empirical evidence of electoral influence through the channel of religious institutions. To test the efficacy of this channel of influence, we study the Chinese government’s attempts to influence Taiwanese elections through religious institutions. By leveraging spatial regression methods, we demonstrate that Mazu temples influence electoral behavior through a localized process. The density of urban Mazu temples in Kaohsiung, Taiwan, which are subject to influence from China, is associated with an increase in vote share for the pro-China party in their neighborhoods. However, the influence on voters in urban and village areas is not homogeneous. In contrast to urban temples, the relationship between village Mazu temples and the electoral results is insignificant.
Political Regimes and Refugee Entries: The Preferences and Decisions of Displaced Persons and Host Governments
Authors: Higashijima Masaaki , Woo Yujin 
Published: May 2024

Abstracts
What drives refugee movements? Focusing on host countries' domestic political institutions, we argue that refugee entry is determined by the political regimes that shape the incentives of both host governments and displaced persons. Specifically, we theorize that there is an inverted U-shaped relationship between political regimes and the volume of refugee entries. When the host country is autocratic, refugee volume becomes smaller due to displaced persons’ unwillingness to risk the high uncertainty of life under such regimes, and when the host country is democratic, refugee volume is similarly curbed due to democratic constraints on the host government. Consequently, a majority of refugees are clustered into anocratic regimes. Using a global dataset, a series of statistical analyses found strong evidence in support of our theoretical expectations regarding not only the hypothesized correlation between regime type and refugee movements but also the preferences of host governments and displaced persons that we theorize underlie this relationship.
The End of the Beginning? Temporality and Bioagency in Pandemic Research
Authors: Mbali Mandisa 
Published: May 2024

Abstract
This paper deals with the ways in which the intellectual and political history of AIDS can assist in the chronological conceptualization of a pandemic such as COVID-19 as it is unfolding. It problematizes the idea of pandemic “beginnings” and “ends” to show that such definitions are shaped by the disciplinary location and thematic foci of relevant scholars. Central to this analysis is the notion that ethical and political contexts affect research on a pandemic in different ways at national and global levels at various points in its trajectory. The article develops this argument in relation to two main themes: firstly, with reference to the history of AIDS research in South Africa; secondly, with the philosophical concept of bioagency to understand the ways in which viruses and humans co-shape the course of epidemics over time. I first make the case for the development of historically informed, long-term ethnographic studies of COVID-19. Using bioagency as a point of departure to consider viruses as social actors, the essay then critiques the notion of bioinformationalism as catalyzing the widening accessibility of biomedical research. Instead, I discuss the biotechnology and pharmaceutical industries as protagonists in the operation of biocapital. I argue that the history of AIDS in South Africa can provide methodological and theoretical insights into how to interpret an unfolding epidemic, outlining an ambitious transdisciplinary research agenda for thinking about the temporality of a pandemic spanning the different, interconnected, scales of life.
Mind the gap: new records of Caenolestes in the Western Andes of Colombia challenge its current biogeographic patterns
Authors: González Baltazar , Ferro-Muñoz Natalia , Calvache-Sánchez Cristian , Rojas Danny , Martin Gabriel M 
Published: May 2024

Abstract
The genus Caenolestes is the most species-rich of the marsupial order Paucituberculata. Two species inhabit Colombia (and also occur in Ecuador) with a discontinuous distribution that has not been accounted for in previous studies—Caenolestes fuliginosus known from the Central and Eastern Andes, and C. convelatus restricted to the Western Andes. Here, we present new and noteworthy records of Caenolestes from the Western Andes at the distributional gap of C. convelatus, and outside the known range of C. fuliginosus. We present detailed comparisons using discrete and continuous diagnostic morphological characters, with type material and additional specimens collected nearby, to assess the identity of the new specimens. We performed statistical analyses at species and subspecies levels, and used a principal components analysis to explore the ordination of the new specimens in morphological space. We found that although these specimens are from the Western Andes, they present traits similar to C. fuliginosus and show great overlap with the morphospace of that species. The new records did not differ statistically with C. fuliginosus or any of its subspecies, but they differed in 20 craniodental measurements from C. convelatus. We also report differences at subspecies level within and between species. Based on these observations, we identified these records as C. fuliginosus, expanding its known distribution to the midportion of the Western Andes, across de Cauca valley. We discuss the biogeography of these 2 species in light of the new data and the context of high Andean habitats, especially regarding the contrasting biogeographical patterns found in other taxa in the Northern Andes. Finally, we discuss the need for a new and exhaustive review of the systematics and biogeography of the genus.
The abundance and distribution of sandflies (with emphasis on Phlebotomus pedifer) (Diptera: Psychodidae) along the altitudinal gradient in Kindo Didaye district, Wolaita Zone, South Ethiopia
Authors: Alemayehu Bereket , Koroto Negese , Tomas Temesgen , Matusala Teshome , Megaze Aberham , Leirs Herwig 
Published: May 2024

Abstract
Understanding the distribution patterns of medically significant sandflies is crucial for effective vector and disease control planning. This study focused on investigating the abundance and distribution of phlebotomine sandflies, specifically emphasizing Phlebotomus pedifer (Diptera: Psychodidae), the vector of Leishmania aethiopica responsible for cutaneous leishmaniasis in the highlands of southern Ethiopia. The study employed CDC light traps and sticky paper traps in various habitats, including human houses, farm fields, and rock cliffs, with and without the presence of hyraxes. The study was conducted along an altitudinal gradient in Kindo Didaye district, Wolaita Zone. A total of 7,994 sandflies belonging to 2 genera, Phlebotomus (26.1%) and Sergentomyia (73.9%), were collected. In the genus Phlebotomus, P. pedifer (74.1%) was the most abundant, followed by P. alexandri (18.05%) and P. gibiensis (7.85%). Altitude showed a strong positive association with the density and distribution of P. pedifer and a negative association with those of P. alexandri, P. gibiensis, and Sergentomyia spp. Furthermore, the study revealed distinct habitat preferences, with P. pedifer showing the highest mean density in hyrax dwellings, followed by human houses, and the lowest in farm fields. These findings provide valuable insights for planning targeted control measures against P. pedifer in both indoor and outdoor environments, particularly in the highland and midland areas of the study region.
Actualizing decolonization: a case for anticolonizing and Indigenizing the curriculum
Authors: Sefa Dei George J , Cacciavillani Alessia 
Published: May 2024

AbstractCalls to decolonize education systems cannot be removed from broader social struggles. Scholars have engaged in theoretical discussions on what decolonization entails, emphasizing the need for transforming thoughts, beliefs, and practices. However, the lack of sustained engagement and widespread resistance to decolonizing the curriculum remain evident, underscoring the urgency to envision new futures and explore relationalities between educators and students.In this article, we delve into the evolving terminologies surrounding decolonization, anticolonization, and Indigenization, emphasizing their pivotal roles in the broader project of educational decolonization. We argue that a reassertion of Indigenous resistance and futurity in higher education forms the cornerstone of this transformative process. Through an examination and understanding of these terminologies, we aim to contribute to the ongoing dialogue surrounding educational decolonization and envision inclusive, equitable, and anticolonial learning environments that centre on Indigenous knowledge and perspectives.
Perianal endometrioma presented as perianal abscess: report of two cases
Authors: Zafirovikj Elena , Nikolovski Andrej , Nane Nikola , Krsteska Blagica 
Published: May 2024

Abstract
Perianal endometriosis is a rare clinical presentation of the extrauterine appearance of endometrium reported in &lt;1% of the cases. The condition is accompanied by perianal cyclic pain and a palpable mass. If diagnosed by physical examination only, the condition may be easily misinterpreted as a perianal abscess and treated improperly with incision, thus resulting in “abscess recurrence.” Additional diagnostic imaging such as endoanal ultrasonography and magnetic resonance imaging should be mandatory to provide an accurate diagnosis and proper treatment resulting in low recurrence rates. We present two cases of perianal endometriomas initially diagnosed and treated as perianal abscesses.