bluuebunny/crossref_metadata_2025_split huggingface dataset:
Need for standard outcome reporting systems in craniosynostosis
Authors: Szpalski Caroline , Weichman Katie , Sagebin Fabio , Warren Stephen M. 
Published: August 2011

Craniosynostosis is the premature fusion of one or more cranial sutures. When a cranial suture fuses prematurely, skull growth is altered and the head takes on a characteristic pathological shape determined by the suture(s) that fuses. Numerous treatment options have been proposed, but until recently there were no parameters or guidelines of care. Establishing such parameters was an important step forward in the treatment of patients with craniosynostosis, but results are still assessed using radiographic measurements, complication rates, and ad hoc reporting scales. Therefore, clinical outcome reporting in the treatment of craniosynostosis is inconsistent and lacks methodological rigor.
Today, most reported evidence in the treatment of craniosynostosis is level 5 (expert opinion) or level 4 (case series) data. Challenges in obtaining higher quality level 1 or level 2 data include randomizing patients in a clinical trial as well as selecting the appropriate outcome measure for the trial. Therefore, determining core outcome sets that are important to both patients and health care professionals is an essential step in the evolution of caring for patients with craniosynostosis.
Traditional clinical outcomes will remain important, but patient-reported outcomes, such as satisfaction, body image, functional results, and aesthetic outcomes, must also be incorporated if the selected outcomes are to be valuable to patients and families making decisions about treatment. In this article, the authors review the most commonly used tools to assess craniosynostosis outcomes and propose a list of longitudinal parameters of care that should be considered in the evaluation, diagnosis, and treatment evaluation of a patient with craniosynostosis.
Streptococcus Bovis Peritonitis Complicating Peritoneal Dialysis—A Review of 10 Years’ Experience
Authors: Yap Desmond Y.H. , To Kelvin K.W. , Yip Terence P.S. , Lui Sing Leung , Chan Tak Mao , Lai Kar Neng , Lo Wai Kei 
Published: August 2011

Objective An association of Streptococcus bovis bacteremia with carcinoma of colon has been reported, but data regarding peritoneal dialysis (PD) peritonitis caused by S. bovis is scarce. In this study, we examined the clinical characteristics, associations, and outcomes of this disease entity. Methods The case records of patients with S. bovis PD peritonitis presenting to 2 renal centers between January 2000 and September 2010 were reviewed. Clinical features and outcomes were identified and analyzed. Results Of cultures from 23 episodes of S. bovis peritonitis in 20 patients (1.28% of all peritonitis episodes at our center), 19 (82.6%) showed S. bovis alone, and 4 (17.4%) showed mixed growth. In 7 episodes, the S. bovis was moderately resistant to penicillin G. Rates of resistance to clindamycin and erythromycin were 43.5% and 47.8% respectively. In 18 episodes (78.3%), a primary response was achieved with a first-generation cephalosporin and an aminoglycoside. In 4 episodes, a secondary response was achieved after a switch from cephalosporin to vancomycin, and in 1 episode with mixed growth, the Tenckhoff catheter had to be removed. Repeat peritonitis occurred in 3 patients at a mean of 50.0 months (range: 24.2 – 83.1 months). Of the 20 patients of S. bovis peritonitis, 10 (50%) underwent either a barium enema or a colonoscopy. One patient had history of colonic carcinoma 2 years before the peritonitis, and a subsequent work-up revealed no recurrence. Three patients had diverticulosis, and one had a concomitant sigmoid polyp. Findings in the other 6 patients were normal. No colorectal malignancy had developed in the remaining 10 patients after a mean follow-up of 76.6 months (range: 0.8 – 125.1 months). Conclusions Outcomes in S. bovis PD peritonitis were favorable, and an association with colorectal cancer was not found in our patients. Routine colonoscopy in these patients remains controversial and should be individualized.
Serum Interleukin 9 Levels Are Increased in Patients with Systemic Sclerosis: Association with Lower Frequency and Severity of Pulmonary Fibrosis
Authors: YANABA KOICHI , YOSHIZAKI AYUMI , ASANO YOSHIHIDE , KADONO TAKAFUMI , SATO SHINICHI 
Published: August 2011

Objective.To determine serum interleukin 9 (IL-9) levels and their clinical associations in patients with systemic sclerosis (SSc).Methods.Serum IL-9 levels were examined by ELISA in 71 patients with SSc, 15 with systemic lupus erythematosus (SLE), 15 with dermatomyositis (DM), 39 with atopic dermatitis, and 28 healthy individuals.Results.Serum IL-9 levels were significantly elevated in SSc patients (84.6 ± 76.0 pg/ml) compared with healthy individuals (40.4 ± 41.7 pg/ml; p < 0.001), and patients with SLE (50.7 ± 52.0 pg/ml; p < 0.05) or DM (50.6 ± 55.8 pg/ml; p < 0.05) or atopic dermatitis (41.8 ± 38.8 pg/ml; p < 0.001). Among SSc patients, there were no differences in serum IL-9 levels between those with limited cutaneous SSc and those with diffuse cutaneous SSc. Patients with SSc and raised IL-9 levels less often had pulmonary fibrosis and decreased percentage vital capacity than those with normal IL-9 levels. IL-9 levels were positively correlated with percentage vital capacity in patients with SSc.Conclusion.Serum IL-9 level was increased in patients with SSc, and was associated with lower frequency and severity of pulmonary fibrosis in SSc. IL-9 could be a protective factor against the development of pulmonary fibrosis in this disease, and as such would be a possible therapeutic target.
Nonpharmacologic Interventions Need Outcomes for Evaluating Complex Interventions in Rheumatic Diseases
Authors: GUILLEMIN FRANCIS , IVERSEN MAURA D. , RAT ANNE-CHRISTINE , OSBORNE RICHARD , PETERSSON INGEMAR F. 
Published: August 2011

Introduction.Nonpharmacologic interventions are themselves complex and are often combined with drugs and other interventions in the treatment of rheumatic diseases. Therefore, overall strategies for treatment are complex interventions. These should be evaluated regarding their processes and outcomes.Methods.The CARE network, an international organization of health professionals (physicians and nonphysicians) and patients conducted a survey in 2008 to identify core outcomes in the ICF perspective, completed with a second survey (2009–2010) with patients in routine practice. These surveys have provided new information about domains to investigate as a basis for evaluating complex interventions.Results.Outcome Measures in Rheumatology Clinical Trials (OMERACT) participants in this Special Interest Group agreed that current outcomes used in pharmacological research are not sufficient if the nonpharmacologic independent or combined contributions are to be assessed; other domains need to be addressed. This is an area of interest for further development.Conclusion.Recommendations are proposed to develop research in the area of outcome for evaluation of complex interventions in rheumatic diseases.
Physical and Social Play of Preschool Children with and without Coordination Difficulties: Preliminary Findings
Authors: Kennedy-Behr Ann , Rodger Sylvia , Mickan Sharon 
Published: August 2011

Introduction: This preliminary study investigated the play skills and frequency of engagement in play of young children with and without motor coordination difficulties. Method: Using a quasi-experimental design with two independent groups, the play of 21 children aged 4–6 years with (n = 11) and without coordination difficulties (n = 10) was assessed using the Revised Knox Preschool Play Scale and the Play Observation Scale, based on 30 minutes of videotape of play at preschool. Motor skills were assessed using the Developmental Coordination Disorder Questionnaire — German and the Movement Assessment Battery for Children — Second Edition. Results: Significant differences were found in developmental play skills between the two groups, specifically in the children's overall play age and in gross and fine motor play, with lower play ages found for children with coordination difficulties. Frequency of engagement and social interaction in play was significantly different: children with coordination difficulties spent more time as onlookers, or in transition, than their typically developing peers. They were more frequently involved in an aggressive incident and had higher frequency of negative affect than the control children during play. Conclusion: Children with coordination difficulties engaged in less mature gross and fine motor play than the control group. Difficulties in social interaction seem to be evident at a younger age than has previously been described. Early identification of these difficulties may provide directions for intervention; however, this needs to be more fully explored with a larger sample.
CA 15–3 Serum Levels in Patients with Ductal Breast Carcinoma: Relationship with Clinicopathological Parameters and Tumor Markers
Authors: González-Sistal Angel , Arias José Ignacio , Ruibal Álvaro 
Published: August 2011

Introduction Cancer antigen 15–3 (CA 15–3) is the most widely used serum marker in diagnosing and monitoring breast cancer. The aim of this work was to analyze preoperative CA 15–3 serum levels in patients with ductal breast carcinoma in relation to 1) clinicopathological parameters, 2) hormone receptors, and 3) tissue-based tumor markers. Methods A group of 340 women with infiltrating ductal carcinoma of the breast who had undergone no prior treatment was studied. These women ranged in age between 27 and 83 years (mean age 61.5±9.9 years). Preoperative CA 15–3 serum levels were determined by an immunoradiometric method. Hormone receptors (estrogen, progesterone and androgen receptors), p53, bcl-2 and Ki67 were determined by different immunohistochemical methods. Epidermal growth factor receptor (EGFR) was analyzed in the cell membranes by radioligand assay whereas cathepsin D and pS2 were determined by immunoradiometric analysis. Tumor ploidy and S-phase fraction were studied by flow cytometry. Results CA 15–3 serum levels were higher in postmenopausal women (p=0.032), in patients with tumors exceeding 2 cm (p=0.003), lymph node involvement (p=0.026), distant metastases (M1) (p<0.0001), S-phase fraction <7% (p=0.015), EGFR <6 fmol/mg protein (p=0.025), and cathepsin D <50 pmol/mg protein (p=0.023). Conclusions Preoperative CA 15–3 serum levels were associated with cell proliferation determined by the S-phase fraction, the concentration of cathepsin D in the cytosol, and the EGFR concentration in the cell membrane.
Isolation and Maintenance of Brachyspira Species
Authors: Stanton Thad B. 
Published: August 2011

AbstractBrachyspira species are anaerobic spirochetes inhabiting intestinal tracts of animals and humans. Several species cause transmissible intestinal diseases of swine and birds. This unit describes methods for the isolation of Brachyspira from fecal samples, cultivation on liquid and solid media, and long term and short term preservation of Brachyspira species. Curr. Protoc. Microbiol. 22:12D.1.1‐12D.1.14. © 2011 by John Wiley & Sons, Inc.
How Word Familiarity Facilitates Visual Search for Verbal Material
Authors: Dampuré Julien , Ros Christine , Rouet Jean‐François , Vibert Nicolas 
Published: July 2011

SummaryTwo experiments assessed the impact of word familiarity on visual search for phrases. Participants' eye movements were recorded while they memorized target phrases and then searched for them within more or less similar phrases. The phrases were written with either familiar or unfamiliar, neuroscience‐specific vocabulary. Most participants did not search for the target by reading lines in a systematic way but scanned the first words of phrases to identify those beginning with the same words as the target. Visual search for unfamiliar target phrases was associated with an increase in the number of non‐target phrases that were scanned. The only search phase during which fixation durations depended on word familiarity was the final recognition of the target phrase. Hence, the data support a model of search within menu‐like displays in which searchers primarily rely on fast, visual match mechanisms and engage in reading‐like processing only during the critical decision‐making phase. Copyright © 2011 John Wiley & Sons, Ltd.
Femoral Morphology and Femoropelvic Musculoskeletal Anatomy of Humans and Great Apes: A Comparative Virtopsy Study
Authors: Morimoto Naoki , De León Marcia S. Ponce , Nishimura Takeshi , Zollikofer Christoph P.E. 
Published: August 2011

AbstractThe proximal femoral morphology of fossil hominins is routinely interpreted in terms of muscular topography and associated locomotor modes. However, the detailed correspondence between hard and soft tissue structures in the proximal femoral region of extant great apes is relatively unknown, because dissection protocols typically do not comprise in‐depth osteological descriptions. Here, we use computed tomography and virtopsy (virtual dissection) for non‐invasive examination of the femoropelvic musculoskeletal anatomy in Pan troglodytes, P. paniscus, Gorilla gorilla, Pongo pygmaeus, and Homo sapiens. Specifically, we analyze the topographic relationship between muscle attachment sites and surface structures of the proximal femoral shaft such as the lateral spiral pilaster. Our results show that the origin of the vastus lateralis muscle is anterior to the insertion of gluteus maximus in all examined great ape specimens and humans. In gorillas and orangutans, the insertion of gluteus maximus is on the inferior (anterolateral) side of the lateral spiral pilaster. In chimpanzees, however, the maximus insertion is on its superior (posteromedial) side, similar to the situation in modern humans. These findings support the hypothesis that chimpanzees and humans exhibit a shared–derived musculoskeletal topography of the proximal femoral region, irrespective of their different locomotor modes, whereas gorillas and orangutans represent the primitive condition. Caution is thus warranted when inferring locomotor behavior from the surface topography of the proximal femur of fossil hominins, as the morphology of this region may contain a strong phyletic signal that tends to blur locomotor adaptation. Anat Rec, 2011. © 2011 Wiley‐Liss, Inc.
Matrigel‐Induced Tubular Morphogenesis of Human Eccrine Sweat Gland Epithelial Cells
Authors: Lei Xia , Liu Bo , Wu Jinjin , Lu Yuangang , Yang Yadong 
Published: August 2011

AbstractHuman eccrine sweat glands are tubule‐structured glands of the skin that are vital in thermoregulation, secretion, and excretion of water and electrolytes. A study of tubular morphogenesis in vitro would facilitate the development of a tissue engineering model for eccrine sweat glands and other tubule‐structured glands. Matrigel, a basement membrane matrix, has been shown to promote differentiation and morphogenesis of many different cell types, including tubular cells. This study investigated the growth, differentiation, and tubular morphogenesis of human eccrine sweat gland epithelial cells cultured in Matrigel. Human eccrine gland epithelial cells were isolated and cultured in vitro. The cell growth in Matrigel was evidenced by the formation of cell clusters, which were observed under an inverted microscope. The internal structure of the cell clusters was further investigated by hematoxylin–eosin (HE) staining and confocal laser scanning microscopy (CLSM) of propidium iodide‐stained nuclei. The results demonstrated that although on a plastic surface or in a collagen gel the cells could not form tubular structures, they formed tubular structures when cultured in Matrigel. Consequently, we conclude that Matrigel can promote tubular morphogenesis of human eccrine sweat gland epithelial cells. Anat Rec, 2011. © 2011 Wiley‐Liss, Inc.
LPV modeling and synthesis for DC propulsion of electric scooters
Authors: Hong Boe‐Shong , Lin Tsu‐Yu , Su Wen‐Jui 
Published: August 2011

AbstractFor electric scooters, this work develops linear parameter‐varying systems (LPV) control synthesis to fulfill the trade‐off between energy consumption per distance and propulsion capability in transience. The synthesized regulator functions as the transmission in the transient state, which is analogous to gear transmission in the steady state. Simulations and experiments are provided to verify the proposed synthesis, wherein a per‐distance strategy is shown to have better performance in terms of energy and motion than a per‐time strategy.Copyright © 2011 John Wiley and Sons Asia Pte Ltd and Chinese Automatic Control Society
Knotenverbindungen für Betonfertigteile – Hinweise für Bemessung und Konstruktion
Authors: Tillmann Mathias 
Published: August 2011

AbstractDas Bemessen und Konstruieren von Knotenverbindungen ist ein Aspekt, in dem sich das Bauen mit Stahlbeton‐ und Spannbetonfertigteilen von der monolithischen Bauweise unterscheidet. Das Verbinden einzeln angefertigter Teile zu einem Gesamttragwerk wird erst durch eine vernünftige Planung und Bemessung und eine richtige Ausführung vor Ort möglich. Der folgende Beitrag ist ein Auszug aus und enthält neben wichtigen Anmerkungen und Hinweisen auch Konstruktionsskizzen, die das Bemessen und Konstruieren von Knotenverbindungen im Betonfertigteilbau erleichtern sollen. Dabei wurde insbesondere darauf geachtet, die Anforderungen nach Eurocode 2 den Anforderungen nach DIN 1045‐1 gegenüberzustellen und Gemeinsamkeiten bzw. Unterschiede herauszuarbeiten.
Entwurf‐ und Bemessungskonzept zum Nachweis von Stahl‐Stahlbetonverbindungen
Authors: Heidolf Thorsten , Roeser Wolfgang 
Published: August 2011

AbstractDas kraftschlüssige Verbinden von Stahlbauteilen mit Stahlbetonbauteilen ist von besonderer Bedeutung im allgemeinen Hochbau und im Fertigteilbau genauso wie auch im Ingenieurbau. Durch die bauaufsichtliche Zulassung des innovativen HSC‐B Schraubanschlusses ist es nun möglich, große Lasten in hybriden Strukturen über Schraubanschlüsse zu übertragen, so dass die spezifischen Werkstoffeigenschaften von Baustahl und Stahlbeton optimal genutzt werden. Im vorliegenden Beitrag werden die Ergebnisse der Zulassungsversuche sowie das daraus abgeleitete Bemessungskonzept des Stahlbauanschlusses vorgestellt. Das Bemessungskonzept wurde auf Basis der Versuchsergebnisse abgeleitet und ist Bestandteil der allgemeinen bauaufsichtlichen Zulassung Z‐15.6‐284.Design concept for concrete steel connectionsThe secure connection between steel components and reinforced concrete structures is important in general, especially in precast construction as well as in civil engineering. Due to the technical approval for innovative HSC‐B concrete steel connection, it is now possible to transfer high loads in hybrid structures with screwed connection. The specific material properties of steel and reinforced concrete are used optimally. In this paper the results of approval tests and the derived design method for the concrete steel connection are presented. The design concept is based on experimental results and is part of National Technical Approval Z‐15.6‐284.
Zulässige Montagestützweiten von Elementdecken mit verstärkten Gitterträgern
Authors: Bertram Guido , Furche Johannes , Hegger Josef , Bauermeister Ulrich 
Published: August 2011

AbstractElementdecken bestehen aus vorgefertigten Stahlbetonplatten und einer aufbetonierten Ortbetonschicht. Die vorgefertigten etwa 5 cm dicken Stahlbetonplatten dienen als verlorene Schalung für den Ortbeton und sind integraler Bestandteil der fertigen Stahlbetondecke. Die Fertigteilplatten sind mit Gitterträgern bewehrt, welche die Eigenbiegesteifigkeit und die Tragfähigkeit der Platten im Montagezustand erhöhen. Das Tragverhalten im Montagezustand kann aufgrund des aufgelösten Querschnitts nicht mit den Berechnungsansätzen für Stahlbetonplatten beschrieben werden. Die Bemessung wird daher in bauaufsichtlichen Zulassungen auf der Grundlage von Versuchen geregelt. Ein bereits zugelassener Gitterträgertyp (Bild 1a) wurde zur Erzielung größerer Montagestützweiten mit größeren Stabquerschnitten versehen. Das Tragverhalten von Fertigteilplatten mit diesen verstärkten Gitterträgern wurde am Institut für Massivbau der RWTH Aachen University in 78 Biege‐ und Querkraftversuchen untersucht. Die wesentlichen Versuchsergebnisse und die daraus abgeleiteten Montagestützweiten der erweiterten allgemeinen bauaufsichtlichen Zulassung werden in diesem Beitrag vorgestellt.Permissible Span of Semi‐precast Slabs in Case of ErectionThe construction of semi‐preacast slabs made of precast lattice girder planks and insitu topping is economic in a large application field. The precast planks consist of a 5 cm thick RC slab serving as permanent formwork for the topping. Lattice girders, set into the slab concrete with their lower chord bars, are used to increase the bending stiffness as well as the bearing capacity of the planks. Furthermore, the described lattice girders consist of an upper chord bar, two lower chord bars and in between diagonal bars. Due to the upper chord bar located above the concrete slab the section modulus as well as the moment of inertia is increased resulting in clearly enlarged permissible spans in the case of erection. The bearing behaviour cannot be described with common bending and shear design methods due to the divided cross section with a slender compression chord. A structural design according to DIN 1045‐1 is not possible, thus the use of lattice girders is regulated by approvals from the German Building Authorities.The lattice girder type E (Fig. 1a) is already approved. Additionally, the diameter of the upper chord bar and the diagonals were enlarged to improve the bearing behaviour in case of erection. The Institute of Structural Concrete at RWTH Aachen University has carried out 78 bending and shear tests to investigate the bearing behaviour of the strengthened lattice girders. The main test results as well as the evaluated permissible spans for the current enhanced approval are presented in this paper.
ST‐Elevation myocardial infarction as a complication of retrograde chronic total occlusion recanalization
Authors: Prayaga Sastry , Uretsky Barry F. , Sachdeva Rajesh 
Published: July 2011

AbstractWith the advent of new tools and techniques including the retrograde approach, success rates for recanalization of chronic total occlusion (CTO) have improved. Numerous cardiac and extracardiac complications during retrograde CTO recanalization have been described. To date the development of ST‐segment elevation myocardial infarction (STEMI) with retrograde recanalization as a result of atheroembolization has not been reported. We report such a case following retrograde recanalization of a totally occluded right coronary artery. © 2011 Wiley Periodicals, Inc.
ChemInform Abstract: Crystallographic, Magnetic and Dielectric Studies of the Potential Multiferroic Cryolite (NH4)3FeF6.
Authors: Goff Richard J. , Tang Chiu C. , Parker Julia E. , Morrison Finlay D. , Lightfoot Philip 
Published: July 2011

AbstractThe title compound is characterized by variable temperature powder XRD and dielectric and magnetic measurements.
ChemInform Abstract: Synthesis, Crystal Structure and Properties of a New Bi‐Dentate Decavanadate [Cu(en)2H2O]2 [H2V10O28]·12H2O.
Authors: Ma Huiyuan , Meng Xin , Sha Jingquan , Pang Haijun , Wu Lizhou 
Published: July 2011

AbstractTitle compound (III) crystallizes in the triclinic space group P$\bar 1$ with Z = 2 (single crystal XRD).
ChemInform Abstract: Ionic Liquid‐Supported (ILS) (S)‐Pyrrolidine Sulfonamide for Asymmetric Michael Addition Reactions of Aldehydes with Nitroolefins.
Authors: Omar Emmy M. , Dhungana Kritanjali , Headley Allan D. , Abdul Rahman Mohd Basyaruddin 
Published: July 2011

AbstractA novel ionic liquid supported organocatalyst (ILOC) is developed, which efficiently catalyzed asymmetric Michael addition reactions of aldehydes to nitroolefins using only two equivalents of the aldehyde.