bluuebunny/crossref_metadata_2025_split huggingface dataset:
Material Objects, Constitution, and Mysterianism
Authors: Benbaji Hagit 
Published: March 2010

AbstractIt is sometimes claimed that ordinary objects, such as mountains and chairs, are not material in their own right, but only in virtue of the fact that they are constituted by matter. As Fine puts it, they are “only derivatively material” (2003, 211). In this paper I argue that invoking “constitution” to account for the materiality of things that are not material in their own right explains nothing and renders the admission that these objects are indeed material completely mysterious. Although there may be metaphysical contexts in which mysterianism can be accepted with equanimity, I further argue, the question of the materiality of quotidian objects is not one of them.
The Main Argument for Value Incommensurability (and Why It Fails)
Authors: Ellis Stephen 
Published: March 2010

AbstractArguments for value incommensurability ultimately depend on a certain diagnosis of human motivation. Incommensurablists hold that each person's basic ends are not only irreducible but also incompatible with one another. It isn't merely that some goals can't, in fact, be jointly realized; values actually compete for influence. This account makes a mistake about the nature of human motivation. Each value underwrites a ceteris paribus evaluation. Such assessments are mutually compatible because the observation that there is something to be said for an outcome from a particular perspective allows for any ultimate evaluation of that outcome; Values can be irreducible without thereby being incommensurable.
Disappearing Appearances: On the Enactive Approach to Spatial Perceptual Content
Authors: Jagnow René 
Published: March 2010

AbstractMany viewers presented with a round plate tilted to their line of sight will report that they see a round plate that looks elliptical from their perspective. Alva Noë thinks that we should take reports of this kind as adequate descriptions of the phenomenology of spatial experiences. He argues that his so‐called enactive or sensorimotor account of spatial perceptual content explains why both the plate's circularity and its elliptical appearance are phenomenal aspects of experience. In this paper, I critique the phenomenal adequacy of Noë's sensorimotor account of spatial perceptual content. I begin by showing that some of its central claims are in conflict with the phenomenology of perceptual experience. I then argue that shape appearances have no phenomenal reality, thus undermining this central motivation for his account.
Higher‐Order Thought and the Problem of Radical Confabulation
Authors: Lane Timothy , Liang Caleb 
Published: March 2010

AbstractCurrently, one of the most influential theories of consciousness is Rosenthal's version of higher‐order‐thought (HOT). We argue that the HOT theory allows for two distinct interpretations: a one‐component and a two‐component view. We further argue that the two‐component view is more consistent with his effort to promote HOT as an explanatory theory suitable for application to the empirical sciences. Unfortunately, the two‐component view seems incapable of handling a group of counterexamples that we refer to as cases of radical confabulation. We begin by introducing the HOT theory and by indicating why we believe it is open to distinct interpretations. We then proceed to show that it is incapable of handling cases of radical confabulation. Finally, in the course of considering various possible responses to our position, we show that adoption of a disjunctive strategy, one that would countenance both one‐component and two‐component versions, would fail to provide any empirical or explanatory advantage.
Categories of Life: The Status of the Camp in Derrida and Agamben
Authors: Cisney Vernon 
Published: March 2010

AbstractThis essay is an exploration of the relationship between Agamben's 1995 text, Homo Sacer, and Derrida's 1992 “Force of Law” essay. Agamben attempts to show that the camp, as the topological space of the state of exception, has become the biopolitical paradigm for modernity. He draws this conclusion on the basis of a distinction, which he finds in an essay by Walter Benjamin, between categories of life, with the “pro‐tagonist” of the work being what he calls homo sacer, or bare life—life that is stripped of its humanity and value. Five years earlier, in 1990, Derrida had given a lecture at UCLA (later published in its entirety as “The Force of Law”) in which he had analyzed the very same essay by Benjamin and had highlighted the distinction between “base life” and “just life.” The implications of his analysis show a discomforting prox‐imity between Benjaminian messianism and the Nazi “final solution,” a conclusion that Agamben dismisses entirely. In this paper, however, I demonstrate that the structures of the two works are quite similar in many important ways. I argue that, though the broad scope of Agamben's work is original in many respects, and I would not wish to reduce Agamben's work to Derridean repetitions, he nevertheless utilizes much more of Derrida's analysis, specifically with respect to the categori‐zation of life, than he would like the reader to believe.
Moral Status As a Matter of Degree?
Authors: DeGrazia David 
Published: March 2010

AbstractSome people contend that fetuses have moral status but less than that of paradigm persons. Many people hold views implying that sentient animals have moral status but less than that of persons. These positions suggest that moral status admits of degrees. Does it? To address this question, we must first clarify what it means to speak of degrees of moral status. The paper begins by clarifying the more basic concept of moral status and presenting two models of degrees of moral status. It then sketches several significant considerations in favor of, and several against, the assertion of degrees of moral status. The paper concludes by drawing lessons from the discussion.
Four Varieties of Character‐Based Virtue Epistemology
Authors: Baehr Jason 
Published: March 2010

AbstractThe terrain of character‐based or “responsibilist” virtue epistemology has evolved dramatically over the last decade — so much so that it is far from clear what, if anything, unifies the various views put forth in this area. In an attempt to bring some clarity to the overall thrust and structure of this movement, I develop a fourfold classification of character‐based virtue epistemologies. I also offer a qualified assessment of each approach, defending a certain account of the probable future of this burgeoning subfield.
Putting the Burden of Proof in Its Place: When Are Differential Allocations Legitimate?
Authors: Dare Tim , Kingsbury Justine 
Published: March 2010

AbstractIt is widely assumed that legitimate differential allocations of the burden of proof are ubiquitous: that in all cases in which opposing views are being debated, one side has the responsibility of proving their claim and if they fail, the opposing view wins by default. We argue that the cases in which one party has the burden of proof are exceptions. In general, participants in reasoned discourse are all required to provide reasons for the claims they make. We distinguish between truth‐directed and non‐truth‐directed discourse, argue that the paradigm contexts in which there are legitimate differential allocations of the burden of proof (law and formal debate) are non‐truth‐directed, and suggest that in truth‐directed contexts, except in certain special cases, differential allocation of the burden of proof is not warranted.
A Phenomenology for Homi Bhabha's Postcolonial Metropolitan Subject
Authors: Lee Emily S. 
Published: March 2010

AbstractHomi Bhabha attends to the figure of the postcolonial metropolitan subject — a racialized subject who is not representative of the first world, yet a symbol of the metropolitan sphere. Bhabha describes their daily lives as inextricably split or doubled. His analysis cannot account for the agonistic moments when one is caught in not knowing, in focusing attention, and in developing understanding. Maurice Merleau‐Ponty's phenomenology with the openness in the horizon of the gestaltian framework better accounts for such splits as moments on the horizon for becoming and grasping something new.
Malebranche and Descartes on Method: Psychologism, Free Will, and Doubt
Authors: Scott David 
Published: March 2010

AbstractThe subject of this paper is Malebranche's relation to Descartes on the question of method. Using recent commentary as a springboard, it examines whether Malebranche advances a nonpsychologistic account of method, in contrast to the psychologism typically thought to characterize the Cartesian view. I explore this question with respect to two issues of central importance to method generally: doubt and free will. My argument is that, despite superficial differences of emphasis, Descartes and Malebranche adopt positions on doubt and free will that effectively ensure that their respective accounts of method are substantially the same.
Leibniz on Concurrence and Efficient Causation
Authors: Bobro Marc E. 
Published: March 2010

AbstractLeibniz defends concurrentism, the view that both God and created substances are causally responsible for changes in the states of created substances. Interpretive problems, however, arise in determining just what causal role each plays. Some recent work has been revisionist, greatly downplaying the causal role played by created substances—arguing instead that according to Leibniz only God has productive causal power. Though bearing some causal responsibility for changes in their perceptual states, created substances are not efficient causes of such changes. This paper argues against such revisionism; not only was Leibniz a consistent advocate of concurrentism (at least in his “mature” years), but also his account of concurrentism involves both God and created substances as efficient causes of the changes in the states of created substances.
Biological Species Are Natural Kinds
Authors: Elder Crawford L. 
Published: March 2010

AbstractThis paper argues that typical biological species are natural kinds, on a familiar realist understanding of natural kinds—classes of individuals across which certain properties cluster together, in virtue of the causal workings of the world. But the clustering is far from exceptionless. Virtually no properties, or property‐combinations, characterize every last member of a typical species—unless they can also appear outside the species. This motivates some to hold that what ties together the members of a species is the ability to interbreed, others that it is common descent. Yet others hold that species are scattered individuals, of which organisms are parts rather than members. But not one of these views absolves us of the need to posit a typical phenotypic profile. Vagueness is here to stay. Some seek to explain the vagueness by saying species are united by “homeostatic property clusters”; but this view collapses into the more familiar realist picture.
Tension within Triangulation
Authors: Goldberg Nathaniel 
Published: March 2010

AbstractPhilosophers disagree about how meaning connects with history. Donald Davidson, who helped deepen our understanding of meaning, even disagreed with himself. As Ernest Lepore and Kirk Ludwig note, Davidson's account of radical interpretation treats meaning as ahistorical; his Swampman thought experiment treats it as historical. Here I show that while Lepore and Ludwig are right that Davidson's views are in tension, they are wrong about its extent. Unbeknownst to them, Davidson's account of radical interpretation and Swampman thought experiment both rely—in different ways—on the same model of triangulation. I revise one of those ways to resolve the tension within Davidson's views. I close by detailing what role history should play in Davidson's views overall.
Open your eyes and look harder! (An investigation into the idea of a responsible visual search)
Authors: Schroer Robert 
Published: March 2010

AbstractIn this paper, I explore and defend the idea that we have epistemic responsibilities with respect to our visual searches, responsibilities that are far more fine‐grained and interesting than the trivial responsibilities to keep our eyes open and “look hard.” In order to have such responsibilities, we must be able to exert fine‐grained and interesting forms of control over our visual searches. I present both an intuitive case and an empirical case for thinking that we do, in fact, have such forms of control over our visual searches. I then show how these forms of control can be used to aim the visual beliefs that result from our searches toward various epistemic goals.
Reasons, Motivations, and Obligations
Authors: Wyckoff Jason 
Published: March 2010

AbstractI argue against Reasons Internalism, the view that possession of a normative reason for the performance of an action entails that one can be motivated to perform that action, and Motivational Existence Internalism, the view that if one is obligated to perform an action, then one can be motivated to perform that action. My thesis is that these positions cannot accommodate the fact that reasonable moral agents are frequently motivated to act only because they believe their contemplated actions to be morally obligatory. The failure to accommodate this fact is reason to reject these two types of internalism about reasons.
The Solution to the Surprise Exam Paradox
Authors: Levy Ken 
Published: March 2010

AbstractThe Surprise Exam Paradox continues to perplex and torment despite the many solutions that have been offered. This paper proposes to end the intrigue once and for all by refuting one of the central pillars of the Surprise Exam Paradox, the “No Friday Argument,” which concludes that an exam given on the last day of the testing period cannot be a surprise. This refutation consists of three arguments, all of which are borrowed from the literature: the “Unprojectible Announcement Argument,” the “Wright & Sudbury Argument,” and the “Epistemic Blindspot Argument.” The reason that the Surprise Exam Paradox has persisted this long is not because any of these arguments is problematic. On the contrary, each of them is correct. The reason that it has persisted so long is because each argument is onlypartof the solution. The correct solution requires all three of them to be combined together. Once they are, we may seeexactlywhy the No Friday Argument fails and therefore why we have a solution to the Surprise Exam Paradox that should stick.
A Defense of Descriptive Moral Content
Authors: Wisdom Jeff 
Published: March 2010

AbstractTerry Horgan and Mark Timmons have recently provided an updated presentation and defense of a metaethical view that they call cognitivist expressivism. Expressivists claim that moral judgments express propositional attitudes that do not represent or describe the external world. Horgan and Timmons agree with this claim, but they also deny the traditional expressivist claim that moral judgments do not express beliefs. On their view, moral judgments are genuine, truth‐apt beliefs, thus making their form of expressivism a cognitivist one. In this essay, I argue that Horgan and Timmons have failed to demonstrate that moral judgments express sui generis, nondescriptive content by showing that at least some moral content is descriptive. In addition, I show how the descriptivist can account for those properties that Horgan and Timmons consider distinctive of moral belief. In doing so, I remove one of the expressivist's most important lines of motivation for positing nondescriptive moral content in the first place. At the end of the essay, I briefly sketch a view that I call partial or modest moral realism.
Free Love: A Hegelian Defense of Same‐Sex Marriage Rights
Authors: Vernon Jim 
Published: March 2010

AbstractBy revisiting Hegel's Philosophy of Right, I mount a Hegelian defense of same‐sex marriage rights. I first argue that Hegel's account of the Idea of freedom articulates both the necessity of popular shifts in the determinations of the institutions of right, as well as the duty to struggle to progressively actualize freedom through them. I then contend that Hegel, by grounding marriage in free consent, clears the path for expanding this ethical institution to include all monogamous couples. Lastly, I close by sketching the specifically Hegelian reasons we ought to actively struggle to expand the institution of marriage.
Decreased
In Vitro
Susceptibility of
Plasmodium falciparum
Isolates to Artesunate, Mefloquine, Chloroquine, and Quinine in Cambodia from 2001 to 2007
Authors: Lim Pharath , Wongsrichanalai Chansuda , Chim Pheaktra , Khim Nimol , Kim Saorin , Chy Sophy , Sem Rithy , Nhem Sina , Yi Poravuth , Duong Socheat , Bouth Denis Mey , Genton Blaise , Beck Hans-Peter , Gobert Jean Gerard , Rogers William O. , Coppee Jean-Yves , Fandeur Thierry , Mercereau-Puijalon Odile , Ringwald Pascal , Le Bras Jacques , Ariey Frederic 
Published: March 2010

ABSTRACT

This study describes the results of
in vitro
antimalarial susceptibility assays and molecular polymorphisms of
Plasmodium falciparum
isolates from Cambodia. The samples were collected from patients enrolled in therapeutic efficacy studies (TES) conducted by the Cambodian National Malaria Control Program for the routine efficacy monitoring of artemisinin-based combination therapy (ACT) (artesunate-mefloquine and artemether-lumefantrine combinations). The isolates (
n
= 2,041) were obtained from nine sentinel sites during the years 2001 to 2007. Among these, 1,588 were examined for their
in vitro
susceptibilities to four antimalarials (artesunate, mefloquine, chloroquine, and quinine), and 851 isolates were genotyped for single nucleotide polymorphisms (SNPs). The geometric means of the 50% inhibitory concentrations (GMIC
50
s) of the four drugs tested were significantly higher for isolates from western Cambodia than for those from eastern Cambodia. GMIC
50
s for isolates from participants who failed artesunate-mefloquine therapy were significantly higher than those for patients who were cured (
P
, <0.001).
In vitro
correlation of artesunate with the other drugs was observed. The distributions of the SNPs differed between eastern and western Cambodia, suggesting different genetic backgrounds of the parasite populations in these two parts of the country. The GMIC
50
s of the four drugs tested increased significantly in eastern Cambodia during 2006 to 2007. These results are worrisome, because they may signal deterioration of the efficacy of artesunate-mefloquine beyond the Cambodian-Thai border.
Synergistic Activities of Three Triazoles with Caspofungin against
Candida glabrata
Isolates Determined by Time-Kill, Etest, and Disk Diffusion Methods
Authors: Kiraz Nuri , Dag Ilknur , Yamac Mustafa , Kiremitci Abdurrahman , Kasifoglu Nilgun , Oz Yasemin 
Published: March 2010

ABSTRACT

Combinations of voriconazole, fluconazole, and itraconazole with caspofungin were evaluated against 50
Candida glabrata
isolates by the time-kill, disk diffusion, and Etest methods. The majority of antifungal combinations were indifferent. By the time-kill method, synergistic activity was detected with eight (16%) of the caspofungin-voriconazole and seven (14%) of the caspofungin-fluconazole combinations, but synergy was not seen with the caspofungin-itraconazole combination. Further comparisons of the Etest and disk diffusion synergy techniques with the time-kill method are warranted.
Detection of E119V and E119I Mutations in Influenza A (H3N2) Viruses Isolated from an Immunocompromised Patient: Challenges in Diagnosis of Oseltamivir Resistance
Authors: Okomo-Adhiambo Margaret , Demmler-Harrison Gail J. , Deyde Varough M. , Sheu Tiffany G. , Xu Xiyan , Klimov Alexander I. , Gubareva Larisa V. 
Published: March 2010

ABSTRACTThe clinical use of the neuraminidase inhibitor (NAI) oseltamivir is associated with the emergence of drug resistance resulting from subtype-specific neuraminidase (NA) mutations. The influenza A/Texas/12/2007 (H3N2) virus isolated from an oseltamivir-treated immunocompromised patient exhibited reduced susceptibility to oseltamivir in the chemiluminescent neuraminidase inhibition (NI) assay (∼60-fold increase in its 50% inhibitory concentration [IC50] compared to that for a control virus). When further propagated in cell culture, the isolate maintained reduced susceptibility to oseltamivir in both chemiluminescent and fluorescent NI assays (∼50- and 350-fold increases in IC50, respectively). Sequencing analysis of the isolate revealed a mix of nucleotides coding for amino acids at position 119 of the NA [E119(V/I)]. Plaque purification of the isolate yielded E119V and E119I variants, both exhibiting reduced susceptibility to oseltamivir. The E119I variant also showed decreased susceptibility to zanamivir and the investigational NAIs peramivir and A-315675. The emergence of E119V variants in oseltamivir-treated patients has been previously reported; however, the E119I mutation detected here is a novel one which reduces susceptibility to several NAIs. Both mutations were not detected in unpropagated original clinical specimens using either conventional sequencing or pyrosequencing, suggesting that these variants were present in very low proportions (<10%) in clinical specimens and gained dominance after virus propagation in MDCK cells. All virus isolates recovered from the patient were resistant to adamantanes. Our findings highlight the potential for emergence and persistence of multidrug-resistant influenza viruses in oseltamivir-treated immunocompromised subjects and also highlight challenges for drug resistance diagnosis due to the genetic instability of the virus population upon propagation in cell culture.
The 6-Aminoquinolone WC5 Inhibits Human Cytomegalovirus Replication at an Early Stage by Interfering with the Transactivating Activity of Viral Immediate-Early 2 Protein
Authors: Loregian Arianna , Mercorelli Beatrice , Muratore Giulia , Sinigalia Elisa , Pagni Silvana , Massari Serena , Gribaudo Giorgio , Gatto Barbara , Palumbo Manlio , Tabarrini Oriana , Cecchetti Violetta , Palù Giorgio 
Published: March 2010

ABSTRACT
WC5 is a 6-aminoquinolone that potently inhibits the replication of human cytomegalovirus (HCMV) but has no activity, or significantly less activity, against other herpesviruses. Here we investigated the nature of its specific anti-HCMV activity. Structure-activity relationship studies on a small series of analogues showed that WC5 possesses the most suitable pattern of substitutions around the quinolone scaffold to give potent and selective anti-HCMV activity. Studies performed to identify the possible target of WC5 indicated that it prevents viral DNA synthesis but does not significantly affect DNA polymerase activity. In yield reduction experiments with different multiplicities of infection, the anti-HCMV activity of WC5 appeared to be highly dependent on the viral inoculum, suggesting that WC5 may act at an initial stage of virus replication. Consistently, time-of-addition and time-of-removal studies demonstrated that WC5 affects a phase of the HCMV replicative cycle that precedes viral DNA synthesis. Experiments to monitor the effects of the compound on virus attachment and entry showed that it does not inhibit either process. Evaluation of viral mRNA and protein expression revealed that WC5 targets an event of the HCMV replicative cycle that follows the transcription and translation of immediate-early genes and precedes those of early and late genes. In cell-based assays to test the effects of WC5 on the transactivating activity of the HCMV immediate-early 2 (IE2) protein, WC5 markedly interfered with IE2-mediated transactivation of viral early promoters. Finally, WC5 combined with ganciclovir in checkerboard experiments exhibited highly synergistic activity. These findings suggest that WC5 deserves further investigation as a candidate anti-HCMV drug with a novel mechanism of action.