bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ag/SiOxCy plasma polymer coating for antimicrobial protection of fracture fixation devices
Authors: Khalilpour Poroshat , Lampe Kai , Wagener Michael , Stigler Brigitte , Heiss Christian , Ullrich Matthias S. , Domann Eugen , Schnettler Reinhard , Alt Volker 
Published: April 2010

AbstractImplant‐related infections are often devastating situations in orthopaedic trauma surgery particularly if multiresistant bacteria are involved. Protection of the implant surface by an antimicrobial coating exhibiting activity against multiresistant bacterial strains is of high interest. Aim of this study was to investigate the antimicrobial effects of an Ag/SiOxCy plasma polymer coating for fracture fixation devices, such as nails, plates, and external fixators, including tests against methicillin‐resistant Staphylococcus aureus (MRSA) and its biocompatibility. The antimicrobial activity of the coating deposited onto 12 × 3 mm2 stainless steel implants was tested in vitro against Staphylococcus aureus, Staphylococcus epidermidis, and MRSA using different testing methods (ASTM E‐2810, JIS Z 2801, proliferation assay). Additionally, the coated devices were implanted into the paravertebral muscle of rabbits and explanted after 2, 7, 14, and 28 days to test the remaining ex vivo antimicrobial activity. For biocompatibility assessment the Ag/SiOxCy plasma polymer coating was tested in vitro according to ISO 10993‐5. The Ag/SiOxCy coating exhibited excellent antimicrobial activity against all tested bacterial strains in all three in vitro tests. Ex vivo testing proved suppression of more than 99.9 % of bacterial proliferation by the coating compared to non‐coated samples even after 28 days. ISO 10993‐5 showed good biocompatibility of the coating without any indications of cytotoxic effects. In summary, Ag/SiOxCy plasma polymer coating showed excellent antimicrobial activity including effectiveness against MRSA and good in vitro biocompatibility. Therefore, it possesses high potential as a prophylactic agent in orthopaedic trauma surgery. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2010.
Cyclin D1 and cyclin D3 show divergent responses to distinct mitogenic stimulation
Authors: Anderson Alexandra A. , Child Emma S. , Prasad Aarathi , Elphick Lucy M. , Mann David J. 
Published: April 2010

AbstractD‐type cyclins predominantly regulate progression through the cell cycle by their interactions with cyclin‐dependent kinases (cdks). Here, we show that stimulating mitogenesis of Swiss 3T3 cells with phorbol esters or forskolin can induce divergent responses in the expression levels, localization and activation state of cyclin D1 and cyclin D3. Phorbol ester‐mediated protein kinase C stimulation induces S phase entry which is dependent on MAPK activation and increases the levels and activation of cyclin D1, whereas forskolin‐mediated cAMP‐dependent protein kinase A stimulation induces mitogenesis that is independent of MAPK, but dependent upon mTor and specifically increases the level and activation of cyclin D3. These findings uncover additional levels of complexity in the regulation of the cell cycle at the level of the D‐type cyclins and thus may have important therapeutic implications in cancers where specific D‐cyclins are overexpressed. J. Cell. Physiol. 225: 638–645, 2010. © 2010 Wiley‐Liss, Inc.
Dynamic MR perfusion imaging: Capability for quantitative assessment of disease extent and prediction of outcome for patients with acute pulmonary thromboembolism
Authors: Ohno Yoshiharu , Koyama Hisanobu , Matsumoto Keiko , Onishi Yumiko , Nogami Munenobu , Takenaka Daisuke , Yoshikawa Takeshi , Matsumoto Sumiaki , Sugimura Kazuro 
Published: April 2010

AbstractPurpose:To compare directly the capabilities of multidetector‐row computed tomography (MDCT) and MRI for disease severity assessment and outcome prediction for acute pulmonary thromboembolism (APTE) patients.Materials and Methods:Fifty consecutive APTE patients underwent MDCT, MR angiography, dynamic perfusion MRI, treatment and follow‐up examination. Pulmonary blood flow (PBF), pulmonary blood volume, and mean transit time maps were generated from perfusion MRI, and all segmental parameters were determined by using region of interest measurements. Receiver operator curve analyses were used to determine the most accurate parameter for diagnosis of the APTE segment. Then, APTE index from perfusion MRI (PEperfusion MRI index), right ventricle/left ventricle (RV/LV) diameter ratio and APTE indexes from embolic burdens observed on MDCT (PECT index) and MR angiography (PEMRA index) were calculated. Finally, ability to differentiate mortality (n = 8) from survival (n = 42) groups and to predict patient outcome were statistically assessed.Results:PBF was a significantly more accurate parameter than others (P < 0.05). When feasible threshold value was applied, specificity and accuracy of RV/LV diameter ratio and PEPerfusion MRI index were significantly higher than those of PECT and PEMRA indexes (P < 0.05). Logistic regression analysis demonstrated that each index was a significant predictor (P < 0.05).Conclusion:Dynamic perfusion MRI can be effective for disease extent assessment and outcome prediction for APTE patients. J. Magn. Reson. Imaging 2010;31:1081–1090. © 2010 Wiley‐Liss, Inc.
Improved coronary MR angiography using wideband steady state free precession at 3 tesla with sub‐millimeter resolution
Authors: Lee Hsu‐Lei , Shankaranarayanan Ajit , Pohost Gerald M. , Nayak Krishna S. 
Published: April 2010

AbstractPurpose:To suppress off‐resonance artifacts in coronary artery imaging at 3 Tesla (T), and therefore improve spatial resolution.Materials and Methods:Wideband steady state free precession (SSFP) sequences use an oscillating steady state to reduce banding artifacts. Coronary artery images were obtained at 3T using three‐dimensional navigated gradient echo, balanced SSFP, and wideband SSFP sequences.Results:The highest in‐plane resolution of left coronary artery images was 0.68 mm in the frequency‐encoding direction. Wideband SSFP produced an average SNR efficiency of 70% relative to conventional balanced SSFP and suppressed off‐resonance artifacts.Conclusion:Wideband SSFP was found to be a promising approach for obtaining noncontrast, high‐resolution coronary artery images at 3 Tesla with reliable image quality. J. Magn. Reson. Imaging 2010;31:1224–1229. © 2010 Wiley‐Liss, Inc.
Depression severity evaluation for female patients based on a functional MRI model
Authors: Qing Lu , Haiteng Jiang , Haiyan Liu , Gang Liu , Gaojun Teng , Zhijian Yao 
Published: April 2010

AbstractPurpose:To develop a functional MRI (fMRI) signal based model that can evaluate depression severity in a numeric form; therefore, depressed patients can be identified during the course of illness, independent from symptoms.Materials and Methods:Data from 20 medication‐free depressed patients and 16 healthy subjects were analyzed. The event‐related fMRI scanning features under sad facial emotional stimuli were extracted as model inputs. Fuzzy logic and a genetic algorithm were used to provide suitable model outputs for numeric estimations of depression.Results:The correlation value r between the model estimations and the professional Hamilton Depression Rating Scales (HAMD) was 0.7886 with P < 0.00016. A typical tracking history for a particular subject has also promised the possibility for early disease warning, when the clinal symptoms are ambiguous or recessive.Conclusion:A numeric and objective estimation for the course of illness can be provided. The model can be used by psychiatrists to track the recovery process. As a simple extended application, the proposed model can be applied to classify subjects into different patterns: major depression, moderate depression, or healthy. J. Magn. Reson. Imaging 2010;31:1067–1074. © 2010 Wiley‐Liss, Inc.
CARS thermometry revisited in lightof the intramolecular perturbation
Authors: Marrocco Michele 
Published: April 2010

AbstractThe rigid rotor approximation (RRA) is commonly assumed in the Raman cross section used in thermometric analysis based on coherent anti‐Stokes Raman scattering (CARS). In this paper, we discuss instead the role of the coupling between molecular vibrations and rotations in view of the alterations found in the amplitude of CARS signals of basic molecules and, in the end, we demonstrate that the deviation of a few percent from the RRA results in corrections to the measured temperature that are comparable to the thermometric accuracy of very well‐known Q‐branch CARS measurements on nitrogen, which is unanimously regarded as the fundamental molecule in CARS thermometry. Copyright © 2010 John Wiley & Sons, Ltd.
Continuously moving table time‐of‐flight angiography of the peripheral veins
Authors: Huff Sandra , Honal Matthias , Baumann Tobias , Hennig Jürgen , Markl Michael , Ludwig Ute 
Published: April 2010

AbstractTime‐of‐flight (TOF) MR angiography allows for noninvasive vessel imaging. To overcome the limited volumetric coverage of standard TOF techniques, the aim of this study was to investigate the combination of TOF and continuously moving table (CMT) acquisitions for peripheral vein imaging based on image subtraction. Two acquisition strategies are presented: a simple two‐step method based on 2‐fold CMT acquisition and an advanced one‐step method requiring only one continuous scan. Image quality of both CMT TOF techniques was evaluated by semiquantitative image grading and by signal‐to‐noise ratio and contrast‐to‐noise ratio analysis for veins of the upper and lower leg in 10 healthy volunteers. Results were compared to a standard stationary two‐dimensional (2D) TOF multistation acquisition. Image grading revealed good image quality for both CMT TOF methods, thereby confirming the feasibility of axial 2D CMT TOF to assess the veins of the lower extremities during a single scan. Quantitative evaluation showed no significant difference in signal‐to‐noise ratio and contrast‐to‐noise ratio compared to the stationary experiment. Additional measurements in three patients with postthrombotic changes and varicosities demonstrated the clinical applicability of the presented methods. CMT TOF provides promising results and permits the detection of various pathologic changes of the venous system. Magn Reson Med 63:1219–1229, 2010. © 2010 Wiley‐Liss, Inc.
Noninvasive temperature mapping with MRI using chemical shift water‐fat separation
Authors: Soher Brian J. , Wyatt Cory , Reeder Scott B. , MacFall James R. 
Published: April 2010

AbstractTissues containing both water and lipids, e.g., breast, confound standard MR proton reference frequency‐shift methods for mapping temperatures due to the lack of temperature‐induced frequency shift in lipid protons. Generalized Dixon chemical shift–based water‐fat separation methods, such as GE's iterative decomposition of water and fat with echo asymmetry and least‐squares estimation method, can result in complex water and fat images. Once separated, the phase change over time of the water signal can be used to map temperature. Phase change of the lipid signal can be used to correct for non‐temperature‐dependent phase changes, such as amplitude of static field drift. In this work, an image acquisition and postprocessing method, called water and fat thermal MRI, is demonstrated in phantoms containing 30:70, 50:50, and 70:30 water‐to‐fat by volume. Noninvasive heating was applied in an Off1‐On‐Off2 pattern over 50 min, using a miniannular phased radiofrequency array. Temperature changes were referenced to the first image acquisition. Four fiber optic temperature probes were placed inside the phantoms for temperature comparison. Region of interest (ROI) temperature values colocated with the probes showed excellent agreement (global mean ± standard deviation: −0.09 ± 0.34°C) despite significant amplitude of static field drift during the experiments. Magn Reson Med 63:1238–1246, 2010. © 2010 Wiley‐Liss, Inc.
Magnetic nanoparticles for imaging dendritic cells
Authors: Kobukai Saho , Baheza Richard , Cobb Jared G. , Virostko Jack , Xie Jingping , Gillman Amelie , Koktysh Dmitry , Kerns Denny , Does Mark , Gore John C. , Pham Wellington 
Published: April 2010

AbstractWe report the development of superparamagnetic iron oxide (SPIOs) nanoparticles and investigate the migration of SPIO‐labeled dendritic cells (DCs) in a syngeneic mouse model using magnetic resonance (MR) imaging. The size of the dextran‐coated SPIO is roughly 30 nm, and the DCs are capable of independent uptake of these particles, although not at levels comparable to particle uptake in the presence of a transfecting reagent. On average, with the assistance of polylysine, the particles were efficiently delivered inside DCs within one hour of incubation. The SPIO particles occupy approximately 0.35% of cell surface and are equivalent to 34.6 pg of iron per cell. In vivo imaging demonstrated that the labeled cells migrated from the injection site in the footpad to the corresponding popliteal lymph node. The homing of labeled cells in the lymph nodes resulted in a signal drop of up to 79%. Furthermore, labeling DCs with SPIO particles did not compromise cell function, we demonstrated that SPIO‐enhanced MR imaging can be used to track the migration of DCs effectively in vivo. Magn Reson Med 63:1383–1390, 2010. © 2010 Wiley‐Liss, Inc.
Characterization and reduction of saturation banding in multiplanar coherent and incoherent steady‐state imaging
Authors: Derakhshan Jamal J. , Griswold Mark A. , Nour Sherif G. , Sunshine Jeffrey L. , Duerk Jeffrey L. 
Published: April 2010

AbstractHypointense band artifacts occur at intersections of nonparallel imaging planes in rapidly acquired MR images; quantitative or numerical analysis of these bands and strategies to mitigate their appearance have largely gone unexplored. The magnetization evolution in the different regions of multiplanar images was simulated for three common rapid steady‐state techniques (spoiled gradient echo, steady state free precession, balanced steady state free precession). Saturation banding was found to be highly dependent on the pulse sequence, acquisition time, and phase‐encoding order. Encoding the center of k‐space at the end of the acquisition of each slice (i.e., reverse centric phase encoding) is demonstrated to be a simple and robust method for significantly reducing the relative saturation in all imaging planes. View ordering and resolution dependence were confirmed in multiplanar abdominal images. The added importance of reducing the artifact in accelerated acquisition techniques (e.g., parallel imaging) is particularly notable in multiplanar balanced steady state free precession images in the brain. Magn Reson Med 63:1415–1421, 2010. © 2010 Wiley‐Liss, Inc.
Neurological patients need evidence‐based urological care
Authors: Wyndaele J.J. , Bruschini H. , Madersbacher H. , Moore K. , Pontari M. , Wein A. 
Published: April 2010

AbstractAimsTo report the conclusion of the Think Thank on Neurourology discussions during the first ICI‐RS meeting in 2009.MethodsDuring a 3‐day meeting a group of specialists discussed evidence‐based medicine in neurourology and made suggestions for future research.ResultsIn the vast majority of patients with neurological disease bladder dysfunction occurs. The actual rules of diagnosis and treatment lack a study related evidence base. From a long list of possible research subjects, prevalence, detrusor pressure, imaging, catheterization and surgery have been first discussed.ConclusionIn each of these subjects, research items are suggested which can help to improve the care in this patient group. Neurourol. Urodynam. 29:662–669, 2010. Copyright © 2010 Wiley‐Liss, Inc.
Secondary relaxations and electrical conductivity in hyperbranched polyester amides
Authors: Turky G. , Sangoro J. R. , Abdel Rehim M. , Kremer F. 
Published: April 2010

AbstractBroadband dielectric spectroscopy is used to investigate molecular dynamics and charge transport in three hyperbranched polyester amides with hydroxyl, phenyl, and stearate terminal groups. At higher temperatures, the dielectric spectra are interpreted in terms of hopping conduction in a spatially randomly varying energy landscape, whereas two secondary dipolar relaxations attributed to librations of the terminal and amide groups dominate the low temperature regime. Despite a shift of more than 3 decades in the dc conductivity upon variation of the end groups, the Barton–Nakajima–Namikawa relation is shown to hold. © 2010 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 48: 1651–1657, 2010
Immiscibility–miscibility phase transformation in blends of poly(ethylene succinate) with poly(L‐lactic acid)s of different molecular weights
Authors: Woo E. M. , Hsieh Ya‐Ting , Chen Wei‐Ting , Kuo Nai‐Tzu , Wang Lai‐Yen 
Published: April 2010

AbstractUsing differential scanning calorimetry (DSC), polarizing optical microscopy (POM), and Fourier transformed infrared spectroscopy (FTIR), upper critical solution temperature (UCST) phase behavior with immiscibility–miscibility transformation in blends of poly(ethylene succinate) (PESu) with poly(lactic acid)s (PLAs), such as poly(D,L‐lactic acid) (PDLLA), poly(L‐lactic acid) (PLLA), poly(D‐lactic acid) (PDLA), differing in D/L configurations and molecular weights were investigated. All three binary blends of PDLLA/PESu, PLLA/PESu, and PESu/PDLA exhibit UCST behavior, which means they are immiscible at ambient temperature but can become miscible upon heating to higher temperatures at 240–268 °C depending on molecular weights. The PLLAs/PESu blends at UCST could be reverted back to the original phase‐separated morphology, as proven by solvent redissolution. The blends upon quenching from above UCST could be frozen into a quasi‐miscible state, where the Flory‐Huggins interaction parameter (χ12) was determined to be a negative value (by melting point depression technique). The interaction between PDLLA and PESu in blend resulted in significant reduction in spherulite growth rate of PESu. Furthermore, blends of PESu with lower molecular weight PLLA or PDLA (Mw of PLLA and PDLA are 152,000 and 124,000 g/mol, respectively), instead of the higher Mw of PDLLA (Mw of PDLLA = 157,000 g/mol), are immiscible with UCST phase behavior, which are affected by molecular weights rather than the ratio of L/D monomer in the chemical structure of PLAs. © 2010 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 48: 1135–1147, 2010
Modelling and analyzing flow diversion in branching channels with symmetric geometry
Authors: Yousefi Somayeh , Ghiassi Reza , Yousefi Saied 
Published: April 2010

AbstractThis paper aims at the investigation and analysis of numerical and laboratory modelling of flow in branched channels with symmetrical geometry and varying hydraulic conditions. Details of velocity and water‐level profiles in branching locations are discussed. In some low‐slop regions like plains, rivers may be branching; or in alluvial plains where the slop is low, meanders may appear. On the other hand, in the mountainous and semi‐mountainous areas with relatively steep slops, arterial rivers can be formed. Therefore, it is important to learn the behaviour of rivers in branching location and to simulate water flow in branching part of rivers.Details of two‐dimensional numerical model in a main channel and secondary downstream branches are explained and results are analysed and compared against experimental data. With respect to the numerical simulation, velocity and depth in different sections of laboratory model are calculated and the corresponding profiles are developed. The water‐level profiles are calculated and drawn using both the numerical and experimental models. Some long narrow eddies are predicted along internal bank of junction. The comparison of numerical and experimental models proves reasonable results for this research. Copyright © 2010 John Wiley & Sons, Ltd.
The effects of organic vapor on alkanethiol deposition via Dip‐pen nanolithography
Authors: Salaita Khalid , Amarnath Anand , Higgins Thomas B. , Mirkin Chad A. 
Published: April 2010

AbstractDip‐pen nanolithography (DPN) is a scanning probe‐based technique that allows for direct delivery of molecules to a range of substrates with sub‐50 nm resolution. This study describes the effect of organic solvent vapor on the deposition rate and feature size of nanostructures deposited via DPN. The transport rate of model molecular inks, 1‐octadecanethiol, and 16‐mercaptohexadecanoic acid were examined under atmospheres of ethanol, methanol, hexane, and dichloromethane. In all cases, presence of an organic vapor increased deposition rate and feature size, in some cases by an order of magnitude. This underscores how the environment can be used to regulate molecular transport rates in a DPN experiment. SCANNING 32: 9–14, 2010. © 2010 Wiley Periodicals, Inc.
Tailored analytical strategies for the investigation of metallic artefacts from the Ayanis Fortress in Turkey
Authors: Angelini E. , Batmaz A. , Cilingiroglu A. , Grassini S. , Ingo G. M. , Riccucci C. 
Published: April 2010

AbstractA noteworthy number of metallic artefacts dating back to 673–645 BC have been found during excavations in the Ayanis Fortress, near the lake of Van. They are large bronze shields, quivers, helmets, arrows and plates, some of which are decorated with cuneiform inscriptions, and demonstrate a high‐level quality of technological competence reached by the ancient craftsmen of Ayanis during the reign of King Rusa II. The artefacts have been studied from a microchemical, micromorphological and microstructural point of view by means of different techniques, from optical microscopy to scanning electron microscopy (SEM), to X‐ray diffraction.Microchemical and microstructural investigations showed metallurgical features of the bronze artefacts and of the corrosion products' layered structures that can be explained in terms of manufacturing processes (repeated cycles of mechanical work and annealing thermal treatments) and environmental context (presence of high amounts of chlorides in the soil that preferentially attack the bronze along the grain boundaries). In particular, the repeated cycles of mechanical work and annealing thermal treatments were carried out to restore the ductility and the malleability of the alloy, thus inducing the crystallisation and the growth of flattened grains as well as impurities segregation phenomena along grain boundaries. Copyright © 2010 John Wiley & Sons, Ltd.
An application for near‐real‐time analysis of XPS data
Authors: Lea A. S. , Swanson K. R. , Haack J. N. , Castle J. E. , Tougaard S. , Baer D. R. 
Published: April 2010

AbstractA platform‐independent application for the analysis of XPS data has been developed with the goal of providing rapid data processing of survey spectra at a more sophisticated level than is typically performed. This application uses an expert systems approach to invoke a set of rules that are applied to the data. The application then uses simple, automated data analysis calculations to generate information on the thickness of any carbon contamination layer, atomic composition corrected for carbon contamination, and segregation (layering) information as soon as the data are collected. Batch processing and automated report generation are features incorporated into this application that would also improve the throughput for data analysis, resulting in substantial labor reduction and cost savings. Copyright © 2010 John Wiley & Sons, Ltd.