bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cyclin D2 and the CDK substrate p220NPAT are required for self‐renewal of human embryonic stem cells
Authors: Becker Klaus A. , Ghule Prachi N. , Lian Jane B. , Stein Janet L. , van Wijnen Andre J. , Stein Gary S. 
Published: November 2009

AbstractSelf‐renewal of pluripotent human embryonic stem (hES) cells utilizes an abbreviated cell cycle that bypasses E2F/pRB‐dependent growth control. We investigated whether self‐renewal is alternatively regulated by cyclin/CDK phosphorylation of the p220NPAT/HiNF‐P complex to activate histone gene expression at the G1/S phase transition. We show that cyclin D2 is prominently expressed in pluripotent hES cells, but cyclin D1 eclipses cyclin D2 during differentiation. Depletion of cyclin D2 or p220NPAT causes a cell cycle defect in G1 reflected by diminished phosphorylation of p220NPAT, decreased cell cycle dependent histone H4 expression and reduced S phase progression. Thus, cyclin D2 and p220NPAT are principal cell cycle regulators that determine competency for self‐renewal in pluripotent hES cells. While pRB/E2F checkpoint control is relinquished in human ES cells, fidelity of physiological regulation is secured by cyclin D2 dependent activation of the p220NPAT/HiNF‐P mechanism that may explain perpetual proliferation of hES cells without transformation or tumorigenesis. J. Cell. Physiol. 222: 456–464, 2010. © 2009 Wiley‐Liss, Inc.
Synthesis of 9‐amino‐5,6,7,8‐tetrahydrothieno[3,2‐b]quinoline and 9‐amino‐5,6,7,8‐tetrahydrothieno[3,2‐b]quinolin‐8‐ol derivatives
Authors: Song Yang‐Heon , Jo Boung Sun 
Published: November 2009

Abstract
magnified image The synthesis of 9‐amino‐5,6,7,8‐tetrahydrothieno[3,2‐b]quinoline (3) and 9‐amino‐5,6,7,8‐tetrahydrothieno[3,2‐b]quinolin‐5‐ol derivatives (4a, 4b, 4c, 4d, 4e, 4f, 4g) in good yield by three‐step procedures starting from 3‐aminothiophene‐2‐carbonitrile and 5‐substituted cyclohexane‐1,3‐dione is described. J. Heterocyclic Chem., (2009).
One‐pot synthesis of polyfunctionalized pyrans catalyzed by basic ionic liquid in aqueous media
Authors: Gong Kai , Wang Hua‐Lan , Luo Jun , Liu Zu‐Liang 
Published: November 2009

Abstract
magnified image An efficient and convenient method for the synthesis of polyfunctionalized 4H‐pyrans has been achieved through the one‐pot condensation of aromatic aldehydes, malononitrile, and 4‐hydroxycoumarin, phenols or active methylene carbonyl compounds such as 1, 3‐cyclohexanedione and dimedone in the presence of 1‐butyl‐3‐methyl imidazolium hydroxide ([bmim]OH) as catalyst in aqueous media. This method offers several advantages short reaction time, high yields, and simple procedure. J. Heterocyclic Chem., (2009).
Influence of soil fertility on dye flavonoids production in weld (Reseda luteola L.) accessions from Portugal
Authors: Gaspar Helena , Moiteiro Cristina , Turkman Antonia , Coutinho João , Carnide Valdemar 
Published: November 2009

AbstractA HPLC‐diode array detector (DAD) methodology was developed to allow the simultaneous identification and quantification of Reseda luteola L. (weld) dye flavonoids, luteolin, apigenin, luteolin 7‐O‐glucoside, apigenin 7‐O‐glucoside, luteolin 3′,7‐O‐diglucoside and luteolin 4′‐O‐glucoside. The method was validated with excellent results in linearity, sensibility, accuracy and precision. This method was applied to evaluate the influence of soil fertility on the production of weld dye flavonoids. The results showed that weld dye capacity is dependent on soil fertility and the origin of seeds. This method proved its reproducibility and can be used to evaluate the dyeing potential of R. luteola samples in a simple and accurate way.
Synthesis of POSS‐Functionalized Polyisobutylene via Direct Initiation
Authors: Hayat Soytaş Serap , Lim Goy Teck , Puskas Judit E. 
Published: November 2009

AbstractPOSS‐functionalized polyisobutylenes (PIBs) were synthesized by carbocationic polymerization using an epoxy‐POSS/TiCl4 initiating system in hexane/methyl chloride (60:40 v/v) solvent mixture at −80 °C. 1H NMR spectroscopy verified the incorporation of one epoxy‐POSS per polymer chain. Light scattering and TEM analysis demonstrated the formation of 50–100 nm sized aggregates and micron‐sized clusters.magnified image
Fluorinated Copolymer Nanoparticles for Multimodal Imaging Applications
Authors: Bailey Mark M. , Mahoney Christine M. , Dempah Kassibla E. , Davis Jeffrey M. , Becker Matthew L. , Khondee Supang , Munson Eric J. , Berkland Cory 
Published: November 2009

AbstractNanomaterials have emerged as valuable tools in biomedical imaging techniques. Here, the synthesis and characterization of a novel fluorinated nanoparticle with potential applications as an MRI contrast agent is reported. Particles were synthesized using a free radical polymerization technique. Secondary ion mass spectrometry analysis showed that the particles' surface contained fluorinated groups and nitrogen‐containing groups. Solid‐state NMR spectroscopy suggested the presence of two distinct fluorine resonances, which conforms to the structure of the fluorinated monomer. Ongoing studies aim to evaluate the performance of the nanoparticles as MRI contrast agents both in vitro and in vivo.magnified image
Nitroxide‐Mediated Copolymerization of 2‐Hydroxyethyl Acrylate and 2‐Hydroxypropyl Acrylate: Copolymerization Kinetics and Thermoresponsive Properties
Authors: Hoogenboom Richard , Popescu Dragos , Steinhauer Wiktor , Keul Helmut , Möller Martin 
Published: November 2009

AbstractPoly(2‐hydroxyethyl acrylate) (PHEA) is an interesting biomaterial with similar biocompatibility as the widespread used poly(2‐hydroxyethyl methacrylate). Poly(2‐hydroxypropyl acrylate) (PHPA) is a less frequently studied polymer that exhibits thermoresponsive behavior in water. Therefore, copolymers of HEA and HPA are interesting thermoresponsive polymers to evaluate as potential biomaterials. Here, we report the copolymerization kinetics of HEA and HPA by nitroxide‐mediated polymerization, employing Blocbuilder® initiator and SG‐1 free nitroxide, revealing an ideal random copolymerization. Furthermore, the thermoresponsive properties of the resulting copolymers are discussed, whereby the cloud points are related to both polymer composition as well as polymer concentration.magnified image
Feasibility and early outcomes of supine‐position craniospinal irradiation
Authors: Huang Fleur , Parker William , Freeman Carolyn R. 
Published: November 2009

AbstractFrom 2000–2007, we treated 14 patients (median age 5.8 years) with medulloblastoma (MB) with craniospinal irradiation (CSI) in the supine position for comfort, setup reproducibility and anaesthesia airway access. Acute toxicity included nausea/vomiting (N = 9), weight loss (median 10.3% (2.2–18.2), N = 10), lymphopenia (all), neutropenia (N = 3) and pancreatitis with Mallory–Weiss tear (N = 1). Five children required hospitalization during treatment. Chemotherapy was adjusted in 6, without CSI delay. After a median follow‐up of 32.4 months (13.3–83.2), two patients recurred, two died of a second CNS malignancy, and one developed leukaemia. All others remain in complete remission. In this small series, CSI was delivered safely in the supine position with early outcomes in line with classical CSI literature. Pediatr Blood Cancer 2010;54:322–325. © 2009 Wiley‐Liss, Inc.
Successful treatment of refractory donor lymphocyte infusion‐induced immune‐mediated pancytopenia with rituximab
Authors: Kato Itaru , Umeda Katsutsugu , Awaya Tomonari , Yui Yoshihiro , Niwa Akira , Fujino Hisanori , Matsubara Hiroshi , Watanabe Ken‐Ichiro , Heike Toshio , Adachi Naoto , Endo Fumio , Mizukami Tomoyuki , Nunoi Hiroyuki , Nakahata Tatsutoshi , Adachi Souichi 
Published: November 2009

AbstractA 6‐year‐old male with chronic granulomatous disease, who was transplanted with bone marrow and exhibited increasing mixed chimerism, subsequently received two donor lymphocyte infusions (DLI). Two weeks after the second DLI, the patient developed acute graft‐versus‐host disease (GVHD) and progressive pancytopenia that was associated with autoantibody production. Conventional treatment did not improve the pancytopenia. However, administration of Rituximab (RTX) (375 mg/m2/week for four consecutive weeks) resulted in a rapid resolution of the pancytopenia. The patient achieved full donor chimerism without GVHD symptoms. RTX can be valuable for managing immune‐mediated cytopenias that arise after DLI and are refractory to conventional therapies. Pediatr Blood Cancer 2010;54:329–331. © 2009 Wiley‐Liss, Inc.
FDG PET imaging of childhood sarcomas
Authors: Mody Rajen J. , Bui Chuong , Hutchinson Raymond J. , Yanik Greg A. , Castle Valerie P. , Frey Kirk A. , Shulkin Barry L. 
Published: November 2009

AbstractBackgroundPositron‐emission tomography (PET) imaging using [18F]fluorodeoxyglucose (FDG) is useful for detection, staging, and monitoring a variety of malignancies, including lymphoma, in adults, but its utility in sarcomas, especially soft tissue sarcomas (STS), in children and young adults is not clear.ProcedureTo evaluate the potential utility of FDG PET in the care of STS in children and young adults, we analyzed 46 PET scans in 25 patients acquired over 12 years. Scans were interpreted by two imaging physicians blinded to findings from other imaging studies and clinical information. Results were compared with computed tomography and magnetic resonance imaging, biopsy results, where available, and clinical follow‐up of at least 12 months.ResultsFor a total of 46 scans in 25 patients, there were 25 true‐positive scans, 3 false‐positive scans, 12 true‐negative scans, and 6 false‐negative scans. The sensitivity of the PET scan was 86%, specificity was 80%, positive predictive value was 89%, and negative predictive value was 67%.ConclusionFDG PET may be a useful imaging modality in the management of children and young adults with STS, although prospective studies are needed to establish its true utility. Pediatr Blood Cancer 2010;54:222–227. © 2009 Wiley‐Liss, Inc.
Identification of distinctive protein expression patterns in colorectal adenoma
Authors: F. Lam Francis , Jankova Lucy , Dent Owen F. , Molloy Mark P. , Kwun Sun Young , Clarke Candice , Chapuis Pierre , Robertson Graham , Beale Philip , Clarke Stephen , Bokey E. Les , Chan Charles 
Published: November 2009

AbstractPurpose: As a pre‐malignant precursor, adenoma provides an ideal tissue for proteome profiling to investigate early colorectal cancer development and provide possible targets for preventive interventions. The aim of this study was to identify patterns of differential protein expression that distinguish colorectal adenoma from normal tissue. Experimental design: Twenty paired samples of adenoma and normal mucosa were analysed by 2‐DE and MALDI‐TOF/TOF MS to detect proteins with ≥2‐fold differential expression. Results: Four proteins were up‐regulated in adenoma (Annexin A3, S100A11, S100P and eIF5A‐1) and three were down‐regulated (Galectin‐1, S100A9 and FABPL). S100P, galectin‐1, S100A9 and FABPL expression was localised by immunohistochemistry. Conclusions and clinical relevance: Distinctive patterns of in vivo protein expression in colorectal adenoma were identified for the first time. These proteins have important functions in cell differentiation, proliferation and metabolism, and may play a crucial role in early colorectal carcinogenesis. The ability to recognise premalignant lesions may have important applications in cancer prevention.
Qlaira: novel multiphasic oral contraceptive taken continuously
Authors: Chaplin Steve , Mansour Diana 
Published: November 2009

AbstractQlaira is a new multiphasic COC that is taken continuously and comprises four combinations of estradiol valerate and the progestogen dienogest, plus two inert tablets. In our New products review, Steve Chaplin presents the clinical data relating to its efficacy, and adverse effects and Dr Mansour discusses its place in contraception. Copyright © 2009 Wiley Interface Ltd
First selective agonist of the neuropeptide Y1‐receptor with reduced size
Authors: Zwanziger Denise , Böhme Ilka , Lindner Diana , Beck‐Sickinger Annette G. 
Published: November 2009

AbstractSelective NPY analogues are potent tools for tumour targeting. Their Y1‐receptors are significantly over‐expressed in human breast tumours, whereas normal breast tissue only expresses Y2‐receptors. The endogenous peptide consists of 36 amino acids, whereas smaller peptides are preferred because of better labelling efficiencies. As Y1‐receptor agonists enhance the tumour to background ratio compared to Y1‐receptor antagonists, we were interested in the development of Y1‐receptor selective agonists. We designed 19 peptides containing theC‐terminus of NPY (28–36) with several modifications. By using competition receptor binding affinity assays, we identified three NPY analogues with high Y1‐receptor affinity and selectivity. Metabolic stability studies in human blood plasma of theN‐terminally 5(6)‐carboxyfluorescein (CF) labelled peptides resulted in half‐lives of several hours. Furthermore, the degradation pattern revealed proteolytic degradation of the peptides by amino peptidases. The most promising peptide was further investigated in receptor activation and internalization studies. Signal transduction assays revealed clear agonistic properties, which could be confirmed by microscopy studies that showed clear Y1‐receptor internalization. For the first time, here we show the design and characterization of a small Y1‐receptor selective agonist. This agonist might be a useful novel ligand for NPY‐mediated tumour diagnostics and therapeutics. Copyright © 2009 European Peptide Society and John Wiley & Sons, Ltd.
Spatially resolved determination of dark saturation current and series resistance of silicon solar cells
Authors: Glatthaar Markus , Haunschild Jonas , Kasemann Martin , Giesecke Johannes , Warta Wilhelm , Rein Stefan 
Published: November 2009

AbstractLuminescence images of silicon solar cells contain information about local recombination properties and local series resistance. It is difficult to separate the information and interpret single images correctly and quantitatively though, which greatly limits the use of single luminescence images, in particular for the application as an in‐production characterization tool. We therefore developed a fast method based on photoluminescence imaging for a spatially resolved coupled determination of the dark saturation current and series resistance (C‐DCR). (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Ab initio studies of the characteristics of hydrogen bonds involving aromatically bound hydroxyl and amino groups and the effects of aromatic fluorine substitution on these interactions
Authors: Riley Kevin E. 
Published: November 2009

AbstractIn this work, we study the hydrogen bonds (H‐bonds) involving hydroxyl and amino groups bonded to phenyl and pyrimidine rings (as H‐bond donors). These types of interactions play important roles in the recognition of ligands by proteins and are also important in the design of materials. The effects of aromatic fluorine substitutions on aromatic rings are also investigated, and it is found that these substitutions can have large effects on the hydrogen bonding interactions that occur in our model systems, making them substantially stronger. This finding offers a new mechanism for the modification of these types of interactions, potentially opening new paths in the design of novel pharmaceuticals and materials. © 2009 Wiley Periodicals, Inc. Int J Quantum Chem, 2010
Chemical reactivity and magnetism of graphene
Authors: Sheka Elena F. , Chernozatonskii Leonid A. 
Published: November 2009

AbstractThe basic problem of weak interaction between odd electrons in graphene is considered within the framework of broken spin‐symmetry single‐determinant approach. The modern implementations of the approach in the form of either unrestricted Hartree‐Fock scheme (UBS HF) or spin‐polarized DFT (UBS DFT) were discussed with particular attention to the applicability of spin‐contaminated solutions of both techniques for the description of electronic properties of graphene. The UBS DFT applications generally reveal the open‐shell character of the singlet state of the object and manifest an extra spin density concentrated on zigzag edge atoms. The UBS HF approach supports these findings but exhibits the extra spin density not only on zigzag edge atoms but on all atoms of the sheet. This very peculiarity permits to quantitatively describe the odd electron behavior via both enhanced chemical reactivity and magnetism. The former is presented in terms of a quantified atomic chemical susceptibility. The magnetic response of graphene sheets is provided by a collective action of all odd electrons and is size dependent. The relative magnetic coupling constant J decreases when the sheet size increases and J approaches the limit value of 10−2 to 10−3 kcal/mol when the sheet size is of a few nanometers. © 2009 Wiley Periodicals, Inc. Int J Quantum Chem, 2010.
Theoretical investigation on sulfur‐containing chelating resin‐divalent metal complexes
Authors: Niu Yuzhong , Feng Shengyu , Ding Yunqiao , Qu Rongjun , Wang Dengxu , Han Jianjun 
Published: November 2009

AbstractThe complex structures and interactions of sulfur‐containing chelating resin poly[4‐vinylbenzyl‐(2‐hydroxyethyl)]sulfide (PVBS), poly[4‐vinylbenzyl‐(2‐hydroxyethyl)]sulfoxide (PVBSO), and poly[4‐vinylbenzyl‐(2‐hydroxyethyl)]sulfone (PVBSO2) with divalent metal chlorides (Cu(II), Ni(II), Zn(II), Cd(II), and Pd(II)) were investigated theoretically. Results indicate that PVBS tends to coordinate with metal ions by sulfur and oxygen atoms forming five‐membered ring chelating complexes; while PVBSO and PVBSO2 prefer to interact with metal ions by the oxygen atom of the sulfoxide or sulfone and hydroxyl group to form six‐membered ring chelating compounds. Theoretical calculations reveal that sulfur atoms of PVBS are the main contributor when coordinate with metal ions, while oxygen atoms also take part in the coordination with Cu(II), Zn(II), and Cd(II). As for PVBSO, the oxygen atoms of sulfoxide group play a key role in the coordination, but sulfur and hydroxyl oxygen also participate in the coordination. Similarly, sulfone group oxygen atoms of PVBSO2 dominate the coordination of Ni(II), Cu(II), and Pd(II), while the affinities of Zn(II) and Cd(II) are mainly attributed to the hydroxyl oxygen atoms. The computational results are in good agreement with the XPS analysis. Combined the theoretical and experimental results, further understanding of the structural information on the complexes was achieved and the adsorption mechanism was confirmed. © 2009 Wiley Periodicals, Inc. Int J Quantum Chem, 2010
Comparative study on formamide–water complex
Authors: Nagaraju M. , Narahari Sastry G. 
Published: November 2009

AbstractThe hydrogen bonding of 1:1 complexes formed between formamide and water molecule have been investigated systematically using Hartree–Fock (HF), hybrid density functional theory (B3LYP), and post‐Hartree–Fock (MP2 and CCSD(T)) methods with range of basis sets 6‐31G(d), cc‐pVXZ (X = D, T, Q) and aug‐cc‐pVYZ (Y = D, T). Three stable structures are considered on the potential energy surface of formamide and water system. The optimized geometric parameters and interaction energies for various isomers at different levels are estimated. The IR frequencies, intensities, and frequency shifts are reported. This study shows that B3LYP/aug‐cc‐pVDZ method gives better performance for formamide‐water complexes. © 2009 Wiley Periodicals, Inc. Int J Quantum Chem, 2010.
Evaluation of one‐electron molecular integrals over complete orthonormal sets of Ψα ‐ETO using auxiliary functions
Authors: Guseinov Israfil I. , Sahin Ercan 
Published: November 2009

AbstractBy the use of expansion and one‐range addition theorems, the one‐electron molecular integrals over complete orthonormal sets of Ψα ‐exponential type orbitals arising in Hartree–Fock–Roothaan equations for molecules are evaluated. These integrals are expressed through the auxiliary functions in ellipsoidal coordinates. The comparison is made using Slater‐, Coulomb‐Sturmian‐, and Lambda‐type basis functions. Computation results are in good agreement with those obtained in the literature. The relationships obtained are valid for the arbitrary quantum numbers, screening constants, and location of orbitals. © 2009 Wiley Periodicals, Inc. Int J Quantum Chem, 2010
Quasi‐classical trajectory stereodynamics study of the Li + HF(v = 0, j = 0) → LiF + H reaction
Authors: Yuan Ming‐Hu , Zhao Guo‐Jun 
Published: November 2009

AbstractIn this work, quasi‐classical trajectory (QCT) calculations for the Li + HF (v = 0, j = 0) → LiF + H reaction, on the Aguado‐Paniagua2‐potential energy surface (AP2‐PES) constructed by Aguado et al. (Aguado et al., J Chem Phys 1997, 107, 10085), have been performed to study the vector properties of the products. The dihedral angle distribution P(ϕr) characterizing the k‐k′‐j′ correlation and the P(θr) distribution characterizing the k‐j′ correlation are calculated and discussed. Furthermore, the angular distribution P(θr, ϕr) of product rotational vectors plotted in polar form in θr and ϕr is presented. Finally, the average rotational alignment factor <P2(cosθr)> is calculated over a collision energy range of 20–450 meV to investigate the variation of the rotational alignment with collision energy. © 2009 Wiley Periodicals, Inc. Int J Quantum Chem, 2010
Quantum chemical topology: The electronic structure of the alkaline nitrites MONO (M = Li, Na, K) studied by means of topological analysis of the electron localization function
Authors: Berski Sławomir , Latajka Zdzisław 
Published: November 2009

AbstractIn the search of the protocovalent bonding, previously recognized in the nitrous acid (HONO), a nature of the chemical bonds in the alkaline nitrites MONO (M = Li, Na, K) has been studied by means of the topological analysis of the Electron Localization Function (ELF) and Electron Localizability Indicator (ELI‐D). Calculations carried out with the B3LYP and MP2(full) methods, in conjunction with the aug‐cc‐pVTZ and 6‐311++G(3df,3pd) basis sets, revealed the cis (C2v, more stable) and trans (Cs) isomers as minima on PES. Alkaline nitrites consist of the alkali metal cation Mδ+ interacting, mainly via electrostatic forces, with the nitrite anion [ONO]δ− (δ ≈ 1e). The covalent NO bonds are characterized by disynaptic basins V(N,O) with the basin populations: 1.58÷1.62e for cis‐Mδ+[ONO]δ− but 1.39÷1.49e for single NO bond and 1.81÷1.87e for formally double NO bond in trans Mδ+[ONO]δ−. The protocovalent nitrogen–oxygen bond has not been observed. The NO bonds are slightly polarized towards the nitrogen atom with the polarity index pNO ≤ 0.12. Two different sets of the hybrid (Lewis) structures are compared leading to different pictures of the bonding. According to NBO data there is a delocalization between the single NO and double NO type bonds, meanwhile results of the ELF analysis emphasize an electron delocalization between the single NO and ionic O−N+ hybrids. © 2009 Wiley Periodicals, Inc. Int J Quantum Chem, 2010
A switching system approach to actuator assignment with limited channels
Authors: Guo Ge , Jin Hui 
Published: November 2009

AbstractThe problem of integrated design of controller and communication sequences is addressed for networked control systems with simultaneous consideration of medium access limitations and network‐induced delays, packet dropouts and measurement quantization. By exploiting a Lyapunov–Krasovskii functional and by making use of novel techniques for switching delay systems, it is shown that linear time invariant systems can be stabilized with delay‐dependent state feedback controllers and communication sequences satisfying appropriate delay‐dependent conditions in terms of linear matrix inequalities. Illustrative examples are provided to show the usefulness and advantage of the developed results. Copyright © 2009 John Wiley & Sons, Ltd.