bluuebunny/crossref_metadata_2025_split huggingface dataset:
First derivative synchronous spectrofluorimetric method for the simultaneous determination of tramadol and celecoxib in their dosage forms and human plasma
Authors: Ramadan Hesham Sameh , Abdel Salam Randa A. , Hadad Ghada M. , Belal Fathalla , Salim Mohamed M. 
Published: May 2024

AbstractOne of the most common features of many different clinical conditions is pain; hence, there is a crucial need for eliminating or reducing it to a tolerable level to retrieve physical, psychological and social functioning. A first derivative synchronous spectrofluorimetry technique is proposed for the simultaneous determination of celecoxib and tramadol HCl, a recent coformulation authorized for treating acute pain in adults. The method includes using synchronous spectrofluorimetry at ∆λ = 80 nm where tramadol HCl was determined using first derivative technique at λ = 230.2 nm, while celecoxib was determined at λ = 288.24 nm. The proposed method was successfully applied to their co‐formulated dosage forms in addition to spiked human plasma and validated in agreement with the guidelines of the International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use (ICH). The linear ranges were found to be 0.50–5.0 and 0.15–0.50, the limits of detection to be 0.088 and 0.011 and the limits of quantification to be 0.266 and 0.032 μg/ml for celecoxib and tramadol, respectively. Statistical analysis revealed no significant difference when compared with previously reported methods as evidenced by the values of the variance ratio F‐test and Student t‐test. The proposed method was successfully applied to commercial dosage forms and spiked human samples. Moreover, the greenness of the proposed method was investigated based on the analytical eco‐scale approach, with the results showing an excellent green scale with a score of 95.
A multi‐species material point method with a mixture model
Authors: Li Bo , Liu Shiguang 
Published: May 2024

AbstractThe material point method (MPM) has attracted more and more attention in computer graphics. It is very successful in simulating both fluid flow and solid deformation, but may fail in simulating multiple fluids and solids coupling. We propose a unified MPM solver for multi‐species simulations. Compared to traditional MPM, we extend the degree of freedom on background grid to store information of multiple materials, so that our framework is able to deal with multiple materials well. The proposed method leverages the advantages of MPM as a hybrid method. We introduce the mixture model into the framework, which was the most widely used for grid‐based multi‐fluid flows. This enables MPM to capture the interaction and relative motion, and animates complex and coupled fluids and solids in a unified manner. A series of experiments are presented to demonstrate effectiveness of our method.
Facial action units detection using temporal context and feature reassignment
Authors: Yang Sipeng , Huang Hongyu , Huang Ying Sophie , Jin Xiaogang 
Published: May 2024

AbstractFacial action units (AUs) encode the activations of facial muscle groups, playing a crucial role in expression analysis and facial animation. However, current deep learning AU detection methods primarily focus on single‐image analysis, which limits the exploitation of rich temporal context for robust outcomes. Moreover, the scale of available datasets remains limited, leading models trained on these datasets to tend to suffer from overfitting issues. This paper proposes a novel AU detection method integrating spatial and temporal data with inter‐subject feature reassignment for accurate and robust AU predictions. Our method first extracts regional features from facial images. Then, to effectively capture both the temporal context and identity‐independent features, we introduce a temporal feature combination and feature reassignment (TC&FR) module, which transforms single‐image features into a cohesive temporal sequence and fuses features across multiple subjects. This transformation encourages the model to utilize identity‐independent features and temporal context, thus ensuring robust prediction outcomes. Experimental results demonstrate the enhancements brought by the proposed modules and the state‐of‐the‐art (SOTA) results achieved by our method.
PIPformers: Patch based inpainting with vision transformers for generalize paintings
Authors: Lee Jeyoung , Kang Hochul 
Published: May 2024

AbstractImage inpainting is a field that has been traditionally attempted in the field of computer vision. After the development of deep learning, image inpainting has been advancing endlessly together with convolutional neural networks and generative adversarial networks. Thereafter, it has been expanded to various fields such as image filing through guiding and image inpainting using various masking. Furthermore, the field termed image out‐painting has also been pioneered. Meanwhile, after the recent announcement of the vision transformer, various computer vision problems have been attempted using the vision transformer. In this paper, we are trying to solve the problem of image generalization painting using the vision transformer. This is an attempt to fill images with painting no matter whether the areas where painting is missing are in or out of the images, and without guiding. To that end, the painting problem was defined as a problem to drop images in patch units for easy use in the vision transformer. And we solved the problem with a simple network structure created by slightly modifying the vision transformer to fit the problem. We named this network PIPformers. PIPformers achieved better values than other papers compared to PSNR, RMSE and SSIM.
Zinc Ions Doping in Layered Bimetallic Nickel‐Cobalt Glycerol Nanosheets for Enhanced Electrochemical Performance of Supercapacitors
Authors: Zhang Lingling , Luo Yumei , Wei Dan , Qiu Shujun , Xu Fen , Cao Weiping , Wang Qingyong , Sun Lixian , Chu Hailiang 
Published: May 2024

AbstractSupercapacitors, distinguished by their high power density, rapid charge‐discharge rates, and prolonged cycle life, hold significant promise in various technological applications. However, limited lower energy density still hinder their practical application. Enhancing intrinsic conductivity by smart choice of elemental combination along with design of nanostructures has the potential to significantly improve the electrochemical performance. Herein, a self‐template method was used for the synthesis of Zn‐doped hydrolyzed NiCo‐glycerate nanosphere (ZnNiCo−G−H) electrode material, assembled with a large number of nanosheets by simple hydrothermal reaction, which can provide abundant active sites and thus achieve superior electrochemical performance. The optimized electrode material displayed a specific capacitance of 1145 F g−1 at 1 A g−1. The fabricated asymmetric supercapacitor, composed of ZnNiCo−G−H and activated carbon as two electrodes, delivered excellent cycling performance with a capacitance retention of 93.8 % after 5000 cycles at the current density of 5 A g−1 and a high energy density of 40 Wh kg−1 at 825 W kg−1, offering great potential as a qualified candidate for the electrochemical energy storage devices.
Ligand‐Free Nickel‐Catalyzed Carbonyl Addition with Organoborons
Authors: Wu Sha‐Sha , Ye Xiaodong , Wang Zi‐Chao , Shi Shi‐Liang 
Published: May 2024

AbstractCarbonyl addition serves as a strategically straightforward and versatile approach for synthesizing alcohols, which are often encountered within bioactive molecules. Herein, we present a ligand‐free, nickel‐catalyzed carbonyl addition process using organoboron reagents. This method enables efficient arylation of readily available ketones or aldehydes, affording a variety of tertiary and secondary alcohols. Key highlights of this protocol include the obviation of external ligands and the tolerance to many functional groups and heterocycles, thereby enhancing its practicality and utility in synthetic organic chemistry.
Thio and Seleno‐Psoralens as Efficient Triplet Harvesting Photosensitizers for Photodynamic Therapy
Authors: Jena Subhrakant , Mohanty Pranay , Rout Rout Saiprakash , Kumar Pati Saswat , Biswal Himansu S. 
Published: May 2024

AbstractThe Psoralen (Pso) molecule finds extensive applications in photo‐chemotherapy, courtesy of its triplet state forming ability. Sulfur and selenium replacement of exocyclic carbonyl oxygen of organic chromophores foster efficient triplet harvesting with near unity triplet quantum yield. These triplet‐forming photosensitizers are useful in Photodynamic Therapy (PDT) applications for selective apoptosis of cancer cells. In this work, we have critically assessed the effect of the sulfur and selenium substitution at the exocyclic carbonyl (TPso and SePso, respectively) and endocyclic oxygen positions of Psoralen. It resulted in a significant redshifted absorption spectrum to access the PDT therapeutic window with increased oscillator strength. The reduction in singlet‐triplet energy gap and enhancement in the spin‐orbit coupling values increase the number of intersystem crossing (ISC) pathways to the triplet manifold, which shortens the ISC lifetime from 10−5 s for Pso to 10−8 s for TPso and 10−9 s for SePso. The intramolecular photo‐induced electron transfer process, a competitive pathway to ISC, is also considerably curbed by exocyclic functionalizations. In addition, a maximum of 115 GM of two‐photon absorption (2PA) with IR absorption (660–1050 nm) confirms that the Psoralen skeleton can be effectively tweaked via single chalcogen atom replacement to design a suitable PDT photosensitizer.
Activation of SO2F2 at a Rhodium PNP Pincer Complex: Ligand Supported S−F Bond Cleavage to Generate NSO2F Derivatives
Authors: Jaeger Ruben , Rachor Simon G. , Ahrens Mike , Braun Thomas 
Published: May 2024

AbstractThe κ2‐(P,N)−phosphine ligand precursor NH(CH2CH2PCy2)2 can be used for the synthesis of the rhodium(I) complex [Rh(CO){ĸ3‐(P,N,P)−Cy2PC2H4NHC2H4PCy2}][Cl] (1). The deprotonated complex [Rh(CO){ĸ3‐(P,N,P)−Cy2PC2H4NC2H4PCy2}] (2) shows a cooperative reactivity of the PNP ligand in the activation reaction of SO2F2 to yield the rhodium fluorido complex trans‐[Rh(F)(CO){ĸ2‐(P,P)−Cy2PC2H4N(SO2F)C2H4PCy2}]2 (3) by S−F bond cleavage. It is remarkable that no reaction was observed when 3 was treated with hydrogen sources e. g. dihydrogen, organosilicon compounds such as triethylsilane or TMS−CF3 and different fluorine sources such as SF4 or Selectfluor®. However, the treatment of complex 3 with XeF2 in the presence of CsF resulted in the formation of the unique fluorido rhodium(III) complex cis,trans‐[Rh(F)3(CO){ĸ2‐(P,P)−Cy2PC2H4N(SO2F)C2H4PCy2}]2 (4). In the presence of pyridine(HF)X or BF3 the fluorido complex 3 converted into the dicationic complexes [Rh(CO){ĸ2‐(P,P)−Cy2PC2H4N(SO2F)C2H4PCy2}]2[XF]2, X=HF (5) or BF3 (6), respectively.
Social relationships and their impact on health‐related quality of life in a long‐term breast cancer survivor cohort
Authors: Belau Matthias Hans , Jung Lisa , Maurer Tabea , Obi Nadia , Behrens Sabine , Seibold Petra , Becher Heiko , Chang‐Claude Jenny 
Published: May 2024

AbstractBackgroundHealth‐related quality of life (HRQOL) has become increasingly important for breast cancer survivors, but clinically relevant declines often persist for many years after treatment. This study aimed to investigate whether social relationships can mitigate or prevent this decline in HRQOL.MethodsData were used from the German population‐based Mamma Carcinoma Risk Factor Investigation (MARIE) cohort of 2022 breast cancer cases with follow‐up information for more than 15 years after diagnosis. Correlations between social integration, social support, and global health status (GHS) as an overall measure of HRQOL were analyzed, and linear regression analysis was performed with structural equation modeling.ResultsThe majority of participants reported high levels of social integration and social support and moderate levels of GHS. Social integration 5 years after diagnosis was associated with GHS 5 years after diagnosis (β = 1.12; 95% CI, 0.25–1.99), but no longitudinal effects were found. Social support 5 years after diagnosis was associated with better GHS 5 years (β = 0.42; 95% CI, 0.36–0.48) and 10 years after diagnosis (β = 0.12; 95% CI, 0.02–0.22), whereas social support 10 years after diagnosis was associated with GHS 10 years (β = 0.29; 95% CI, 0.20–0.39) and 15 years after diagnosis (β = 0.10; 95% CI, 0.01–0.21).ConclusionsThese results confirm that social relationships positively influence HRQOL in long‐term breast cancer survivors and that their association should receive more attention clinically and beyond routine care.
Posttransplant cyclophosphamide versus anti‐thymocyte globulin versus combination for graft‐versus‐host disease prevention in haploidentical transplantation for adult acute myeloid leukemia: A report from the European Society for Blood and Marrow Transplantation Acute Leukemia Working Party
Authors: Bazarbachi Abdul‐Hamid , Labopin Myriam , Raiola Anna Maria , Blaise Didier , Arcese William , Santarone Stella , Koc Yener , Bramanti Stefania , Kulagin Alexander , Kwon Mi , Sica Simona , Sanz Jaime , Brissot Eolia , Nagler Arnon , Ciceri Fabio , Mohty Mohamad 
Published: May 2024

AbstractBackgroundThe optimal choice for graft‐versus‐host disease (GVHD) prophylaxis in haploidentical stem cell transplantation (haplo‐SCT) remains debatable. Posttransplant cyclophosphamide (PTCy) and anti‐thymocyte globulin (ATG) are two common strategies, but little is known about their combination.MethodsUsing the European Society for Blood and Marrow Transplantation (EBMT) registry, the authors identified 3649 adult patients with acute myeloid leukemia (AML) who underwent haplo‐SCT in complete remission between 2007 and 2021 at 260 EBMT‐participating centers who received either PTCy (n = 2999), ATG (n = 358), or combination prophylaxis (n = 292). Cord blood transplants, combined bone marrow and peripheral grafts, and transplants with ex vivo graft manipulation were excluded. Median follow‐up was 31.8 months.ResultsOn multivariate analysis, adjusting for patient age and performance status, disease status at transplant, cytogenetic risk, conditioning intensity, stem cell source, female‐to‐male graft, and donor and patient CMV status, we present the following. Compared to PTCy, ATG had a higher risk of nonrelapse mortality (hazard ratio [HR], 1.6; p = .003), worse leukemia‐free survival (HR, 1.4; p = .002), overall survival (HR, 1.49; p = .0009), and GVHD‐free and relapse‐free survival (HR, 1.29; p = .012). The combination of PTCy and ATG, however, led to significantly reduced rates of grade 2–4 (HR, 0.51; p = .0003) and grade 3–4 (HR, 0.5; p = .018) acute GVHD and did not affect any transplant outcomes compared to PTCy without ATG.ConclusionThe authors conclude that ATG alone is a less effective prophylaxis strategy compared to PTCy, however, the combination of PTCy and ATG is superior to either monotherapy. They propose that this combination could be considered a potential new standard of care for GVHD prophylaxis in haplo‐SCT for AML.
Efficacy of teplizumab for treatment of type 1 diabetes: A meta‐analysis of randomized controlled trials
Authors: Heidari Ehsan , Shafiee Arman , Noorian Shahab , Rafiei Mohammad Ali , Abbasi Mohammad , Amini Mohammad Javad , Safari Omid , Aghamahdi Fatemeh , Bakhtiyari Mahmood 
Published: May 2024

AbstractBackgroundThe management of Type 1 Diabetes Mellitus (T1DM) is a significant clinical challenge. This study evaluated the efficacy of teplizumab, an immunomodulatory drug, in patients with T1DM, using a systematic review and meta‐analysis approach.MethodsWe systematically searched multiple databases including Medline, Scopus, and others up to 10 January 2024, without language or regional restrictions. We included randomized controlled trials (RCTs) comparing teplizumab with placebo in T1DM patients.ResultsOur analysis incorporated 8 RCTs, predominantly involving participants aged 7–35 years, diagnosed with T1DM and treated with 14‐day courses of teplizumab. The primary outcomes included insulin use, C‐peptide levels, and HbA1c levels. We observed a significant reduction in insulin use in the teplizumab group standardised mean difference of −0.50 (95% Confidence Interval [CI]: −0.76 to −0.23, p < 0.001; I2 = 49%). C‐peptide levels were consistently higher in the teplizumab group, indicating improved endogenous insulin production. However, no significant change was noted in HbA1c levels between the groups. Quality assessment indicated a low risk of bias in most studies.ConclusionsTeplizumab has a significant impact on reducing insulin dependence and enhancing endogenous insulin production in T1DM patients. However, its effect on long‐term glycaemic control, as indicated by HbA1c levels, remains inconclusive.
Implications of trial eligibility in patients with heart failure with mildly reduced or preserved ejection fraction
Authors: Peters Anthony E. , Clare Robert M. , Chiswell Karen , Harrington Josephine , Kelsey Anita , Hernandez Adrian , Felker Gary Michael , Mentz Robert J. , DeVore Adam D. 
Published: May 2024

AbstractAimsClinical trials in heart failure with mildly reduced or preserved ejection fraction (HFmrEF/HFpEF) commonly have detailed eligibility criteria. This may contribute to challenges with efficient enrolment and questions regarding the generalizability of trial findings.Methods and resultsPatients with HFmrEF/HFpEF from a large US healthcare system were identified through a computable phenotype applied in linked imaging and electronic health record databases. We evaluated shared eligibility criteria from five recent/ongoing HFmrEF/HFpEF trials (PARAGON‐HF, EMPEROR‐Preserved, DELIVER, FINE‐ARTS, and SPIRRIT‐HFpEF) and compared clinical and echocardiographic features as well as outcomes between trial‐eligible and trial‐ineligible patients. Among 5552 patients with HFpEF/HFmrEF, 792 (14%) were eligible for trial consideration, having met all criteria assessed. Causes of ineligibility included lack of recent loop diuretics (37%), significant pulmonary disease (24%), reduced estimated glomerular filtration rate (17%), recent stroke/transient ischaemic attack (13%), or low natriuretic peptides (12%); 53% of ineligible patients had >1 reason for exclusion. Compared with eligible patients, ineligible patients were younger (age 71 vs. 75 years, P < 0.001) with higher rates of coronary artery disease (66% vs. 59%, P < 0.001) and peripheral vascular disease (40% vs. 33%, P < 0.001), but less mitral regurgitation, lower E/e′ ratio, and smaller left atrial sizes. Both eligible and ineligible patients demonstrated high rates of structural heart disease consistent with HFpEF [elevated left atrial size or left ventricular (LV) hypertrophy/increased LV mass], although this was slightly higher among eligible patients (95% vs. 92%, P = 0.001). The two cohorts demonstrated similar LV global longitudinal strain along with a similar prevalence of atrial fibrillation/flutter, hypertension, and obesity. Ineligible patients had similar all‐cause mortality (33% vs. 33% at 3 years) to those eligible but lower rates of heart failure hospitalization (20% vs. 28% at 3 years, P < 0.001).ConclusionsAmong patients with HFmrEF/HFpEF from a large health system, approximately one in seven were eligible for major trials based on key criteria applied through a clinical computable phenotype. These findings highlight the large proportion of patients with HFmrEF/HFpEF ineligible for contemporary trials for whom the generalizability of trial findings may be questioned and further investigation would be beneficial.
TMPA‐based Cavitary Cobalt (II) Funnel Complexes
Authors: Nyssen Nicolas , Abudayyeh Abdullah , Zhurkin Fedor , Aoun Pamela , Višnjevac Aleksandar , Colasson Benoit , Jabin Ivan , Reinaud Olivia 
Published: May 2024

AbstractThe synthesis of a series of mononuclear, dicationic CoII funnel complexes is reported herein. Three ligands Calix‐TMPAX present a calix[6]arene cone closed at its small rim by a tris(2‐pyridylmethyl)amine (TMPA) unit and differ by the nature of three cavity walls, anisole, phenol or quinone. The X‐ray diffraction structure of [CoII(MeCN)Calix‐TMPAOMe](ClO4)2 displays a trigonal bipyramidal geometry, with Co bound to all 4 nitrogen atoms of the TMPA cap, and to one MeCN guest molecule buried inside the calixarene cavity. All complexes were fully characterized in solution as high spin 5‐coordinate species using various techniques, including 1H NMR spectroscopy. For comparison purpose, an analogous CoII complex based on the TMPACH2OH ligand, devoid of a calixarene core, was synthetized. Its X‐ray structure shows a dicationic 7‐coordinate cobalt(II) center in the N4O3 environment provided by the ligand, leaving no space for exogenous ligand binding. This contrasts with the 5‐coordinate complexes obtained with the calix‐ligands that allow guest‐ligand binding and exchange. A brief overview of the coordination properties of the calix‐complexes, compared to those obtained with TMPA ligands, devoid of a cavity, highlights major differences in terms of complexation kinetics, geometry, coordination to the labile site, anion affinity, nuclearity, and stability.
Burnout in emergency physicians in Hong Kong—A cross‐sectional study on its prevalence, associated factors, and impact
Authors: Chan Tsz Kit , Lui Chun Tat , Wu Wing Yee Clara , Rainer Timothy , Leung Chin San 
Published: May 2024

AbstractObjectiveTo evaluate the prevalence of burnout, its underlying personal or occupational stressors, and impact on individual well‐being and patient care.DesignCross‐sectional survey.ParticipantsAll emergency physicians in the public and the private sector in Hong Kong.MethodSelf‐administered, anonymous, voluntary questionnaires were distributed in physical and electronic forms from April to June 2022. Burnout was assessed by the Maslach Burnout Inventory (MBI). Stressors were assessed by questions on demographic, occupational, and social background. Impact was assessed by the Patient Health Questionnaire‐9 (PHQ‐9) for depression and questions on job satisfaction and self‐perceived patient care.ResultsThe response rate was 37.8% (n = 241). Prevalence of high overall burnout was 28.2% (n = 68), with 47.7% (n = 115) having high emotional exhaustion, 63.1% (n = 152) high depersonalization, and 56% (n = 135) low personal accomplishment. A higher burnout rate was observed in younger age, female, not married, job position (associate consultant, resident specialist, and higher trainee), working on shift duty, more night shifts, and consecutive shifts. Burnout is also associated with depression, suicidal idea, consideration of quitting, less job satisfaction, and less favorable patient care (p < 0.05).ConclusionBurnout is prevalent in emergency physicians in Hong Kong, and its impact on individual well‐being and clinical care was evident. A higher burnout rate was observed in younger doctors and also fellows. Identified stressors such as shift pattern should be addressed and potentially improved. Further strategies should be explored to reduce burnout in our colleagues.