bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationships Among Baseline Concussion Balance Test and Gaze Stability Test Scores in Division-I Collegiate Athletes
Authors: Quintana Carolina P. , Olson Anne D. , Heebner Nicholas R. , Hoch Matthew C. 
Published: April 2024

Context: Sports-related concussions are commonly occurring injuries as a result of sports and recreation that may cause alterations in brain functioning. It is important to be able to evaluate the impact of these injuries on function to manage the injury recovery and ensure recovery. Recent literature suggests the use of objective evaluation strategies in a multifaceted approach to evaluate and manage these injuries. It is important to understand the relationships between the assessments and how best to utilize each assessment. The purpose of this study was to investigate if relationships exist between measures of vestibular function at baseline in assessments that may be used following sports-related concussions. Additionally, a secondary purpose was to determine if self-reported symptoms were related to performance on the assessments. This study aimed to identify if these assessments measured independent functions of the vestibulo–ocular reflex or if some redundancy existed among the assessment strategies. Design: A cross-sectional study design was used in a cohort of collegiate athletes ages 18–24. Methods: Participants completed demographics questionnaires, the Post-Concussion Symptom Scale, Gaze Stabilization Test, and Concussion Balance Test. Spearman rho correlations were used to examine the relationships between the measures. Results: One hundred and thirty-five collegiate athletes (82 males and 53 females) were included, representative of 3 sports (cheerleading, soccer, and football) with a mean age of 19.77 (1.42) years old. There were weak to moderate, significant relationships between measures of Gaze Stabilization Test and Concussion Balance Test errors (r = .20–.31, P = .001–.03). Conclusions: The direction of these relationships indicated that greater Concussion Balance Test errors were associated with greater Gaze Stabilization Test performance. These relationships may be attributed to the difficulty created by the foam conditions and the integration of more complex sensory tasks required to maintain balance during the more difficult conditions.
The nucleoside analog 4′-fluorouridine suppresses the replication of multiple enteroviruses by targeting 3D polymerase
Authors: Chen Yongkang , Li Xiaohong , Han Fengyang , Ji Beihong , Li Yuan , Yan Jingjing , Wang Min , Fan Jun , Zhang Shuye , Lu Lu , Zou Peng 
Published: April 2024

ABSTRACT

Human enteroviruses are the major pathogens causing hand-foot-and-mouth disease in infants and young children throughout the world, and infection with enterovirus is also associated with severe complications, such as aseptic meningitis and myocarditis. However, there are no antiviral drugs available to treat enteroviruses infection at present. In this study, we found that 4′-fluorouridine (4′-FlU), a nucleoside analog with low cytotoxicity, exhibited broad-spectrum activity against infections of multiple enteroviruses with EC50 values at low micromolar levels, including coxsackievirus A10 (CV-A10), CV-A16, CV-A6, CV-A7, CV-B3, enterovirus A71 (EV-A71), EV-A89, EV-D68, and echovirus 6. With further investigation, the results indicated that 4′-FlU directly interacted with the RNA-dependent RNA polymerase of enterovirus, the 3D
pol
, and impaired the polymerase activity of 3D
pol
, hence inhibiting viral RNA synthesis and significantly suppressing viral replication. Our ﬁndings suggest that 4′-FlU could be promisingly developed as a broad-spectrum direct-acting antiviral agent for anti-enteroviruses therapy.
Identification of novel resistance-associated mutations and discrimination within whole-genome sequences of fluoroquinolone-resistant
Mycobacterium tuberculosis
isolates
Authors: Chong Yingzhi , Li Xueying , Long Yifei , Pei Shengfei , Ren Qi , Feng Fumin , Zhang Haibo 
Published: April 2024

ABSTRACT

This study aims to elucidate additional mutation loci associated with fluoroquinolone (FQ) resistance and evaluate the discriminatory capacity of mutation loci and allele mutation frequencies in identifying FQ-resistant
Mycobacterium tuberculosis
(MTB) isolates. A random selection of isolates was extracted from an ongoing collection. Drug resistance was determined using the resazurin microtiter assay (REMA) as the gold standard. Mutation loci and the burden of mutations in the quinolone resistance-determining region (QRDR) were elucidated through whole-genome sequencing (WGS). Novel amino acid mutations, namely, G520D and G520T, were identified in the gyrB and associated with FQ resistance. In the context of distinguishing FQ-resistant isolates, the AUC for the QRDR mutation frequency burden (0.969) surpassed that of the mutation locus (0.929), and this difference was statistically significant (
P
= 0.03). Furthermore, using the resistance mutation locus as a reference, setting the QRDR mutation frequency burden threshold at 1.31% resulted in a 3.60% increase in the accuracy of classifying FQ-resistant isolates (NRI = 3.60%,
P
< 0.001). The QRDR mutation frequency burden appears to offer superior diagnostic efficacy in discriminating FQ-resistant isolates compared to qualitative detection of mutant loci.

IMPORTANCE

Fluoroquinolone (FQ) drugs are recommended as second-line drugs for the treatment of multidrug-resistant tuberculosis. With the massive use of FQ drugs in the clinical treatment of tuberculosis (TB), there is an increasing rate of drug resistance to FQ drugs. In this study, we identified and demonstrated novel amino acid mutations associated with FQ resistance in
Mycobacterium tuberculosis
(MTB), and we quantified the mutation sites and identified the quinolone resistance-determining region (QRDR) mutation frequency burden as a novel diagnostic method for FQ resistance. We hope that the results of this study will provide data support and a theoretical basis for the rapid diagnosis of FQ-resistant MTB.
Thick- and thin-skinned contractional styles and the tectonic evolution of the northern Sangre de Cristo Mountains, Colorado, USA
Authors: Lindsey David A. , Caine Jonathan Saul 
Published: April 2024

AbstractThe Sangre de Cristo Mountains of southern Colorado and northern New Mexico, USA, contain an unusual combination of thick- and thin-skinned contractional structures involving both basement and cover rocks in the Laramide Rocky Mountain foreland. These structures are truncated by down-faulted extensional basins to the east and west. Together with synorogenic sediments, these structures preserve a record of the rise of the Ancestral Rocky Mountains, the Laramide orogeny, and Rio Grande rifting. Laramide structures within the mountains provide clues to processes that link the three events and to necessary conditions for thin-skinned and thick-skinned contractional structures to form together in continental interiors.To examine the full variety of structural styles, a portion of the northern Sangre de Cristo fold- and-thrust belt in Colorado was described and interpreted using geologic maps and structural cross-sections. Stratigraphic relations of the Ancestral Rocky Mountain highlands and basin fill were reconstructed from existing maps. These relations allow identification of faults inherited from the Ancestral Rocky Mountains, differentiation of thrust sheets, and in some cases, estimation of the magnitude of displacement. To examine relations between Laramide thrusts and Rio Grande rifting, kinematic data were collected from a thrust fault adjacent to rift faults.Three thrust fault styles were recognized: thin-skinned basement, thin-skinned cover rocks, and thick-skinned basement. Thin-skinned thrusts arising from a hinterland beneath the present San Luis Valley carried sheets of Proterozoic basement rocks northeast over a Laramide foreland. These basement thrusts are interpreted to be faults of the Ancestral Rocky Mountains that reactivated during the Laramide orogeny. The Laramide foreland consists of thin-skinned thrusts and folds in sedimentary cover rocks as young as 49 Ma. Both thin-skinned thrusts in basement and cover rocks are bounded by thick-skinned basement thrusts that moved intermittently throughout the Laramide orogeny.We infer that thin-skinned thrusts form in continental interiors where deformation is focused in weak strata of thick basin fill and in fluid-reaction weakened preexisting faults in basement rocks. Both conditions are met in the Sangre de Cristo Mountains. Basement thrusts adjacent to the San Luis Valley contain evidence of plastic contractional microstructures overprinted by extensional microstructures that may record the transition from Laramide contraction to Rio Grande extension of the crust.
Trends in outcomes used to measure the effectiveness of UK-based support interventions and services targeted at adults with experience of domestic and sexual violence and abuse: a scoping review
Authors: Carlisle Sophie , Bunce Annie , Prina Matthew , Cook Elizabeth , Barbosa Estela Capelas , McManus Sally , Feder Gene , Lewis Natalia V 
Published: April 2024

ObjectivesIn the UK, a range of support services and interventions are available to people who have experienced or perpetrated domestic and sexual violence and abuse (DSVA). However, it is currently not clear which outcomes and outcome measures are used to assess their effectiveness. The objective of this review is to summarise, map and identify trends in outcome measures in evaluations of DSVA services and interventions in the UK.DesignScoping review.Data sourcesMEDLINE, EMBASE, PsycINFO, Social Policy and Practice, ASSIA, IBSS, Sociological abstracts and SSCI electronic databases were searched from inception until 21 June 2022. Grey literature sources were identified and searched.EligibilityWe included randomised controlled trials, non-randomised comparative studies, pre–post studies and service evaluations, with at least one outcome relating to the effectiveness of the support intervention or service for people who have experienced and/or perpetrated DSVA. Outcomes had to be assessed at baseline and at least one more time point, or compared with a comparison group.Charting methodsOutcome measures were extracted, iteratively thematically grouped into categories, domains and subdomains, and trends were explored.Results80 studies reporting 87 DSVA interventions or services were included. A total of 426 outcome measures were extracted, of which 200 were used more than once. The most commonly reported outcome subdomain was DSVA perpetration. Cessation of abuse according to the Severity of Abuse Grid was the most common individual outcome. Analysis of temporal trends showed that the number of studies and outcomes used has increased since the 1990s.ConclusionsOur findings highlight inconsistencies between studies in outcome measurement. The increase in the number of studies and variety of measures suggests that as evaluation of DSVA services and interventions matures, there is an increased need for a core of common, reliable metrics to aid comparability.Protocol registrationhttps://osf.io/frh2e.
Appropriateness of prescribing profiles and intake adherence to non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation: analysis of a retrospective longitudinal study using real-world data from Northern Portugal (AF-React Study)
Authors: Silva Pinto Susana , Henriques Teresa S , Teixeira Andreia Sofia Costa , Monteiro Hugo , Martins Carlos 
Published: April 2024

ObjectivesThis study aimed to assess the appropriateness of prescribing profiles and intake adherence to non-vitamin K antagonist oral anticoagulants (NOACs) in patients with atrial fibrillation (AF).DesignRetrospective longitudinal study.SettingThe study was conducted in the Regional Health Administration of Northern Portugal.ParticipantsThe authors selected a database of 21 854 patients with prescriptions for NOACs between January 2016 and December 2018 and were classified with AF until December 2018.Outcome measuresThe appropriate dosage of NOAC for patients with AF divided into three categories: contraindicated, inconsistent and consistent, based on the 2020 European Society of Cardiology guidelines for AF.ResultsDabigatran had a lower percentage of guideline-consistent doses (n=1657, 50.1%) than other drugs such as rivaroxaban (n=4737, 81.6%), apixaban (n=3830, 78.7%) and edoxaban (n=436, 82.1%). Most patients with an inconsistent dose were prescribed a lower dose than recommended based on their glomerular filtration rate (GFR). Among patients younger than 75 years with GFR >60 mL/min, 59.8% (n=10 028) had an adequate GFR range, while 27.8% (n=7166) of GFR measurements from patients older than 75 years old and 29.4% (n=913) of GFR measurements from patients younger than 75 years with GFR <60 mL/min were within an adequate time range. Adherence to NOACs varied across different drugs, with 59.1% (n=540) adhering to edoxaban, 56.3% (n=5443) to rivaroxaban, 55.3% (n=3143) to dabigatran and 53.3% (n=4211) to apixaban.ConclusionsDabigatran had the lowest percentage of guideline-consistent doses. Patients younger than 75 years with GFR >60 mL/min had the highest percentage with an adequate GFR range, while other groups who require closer GFR monitoring had lower percentages within an adequate GFR range. Adherence to NOACs differed among different drugs, with greater adherence to treatment with edoxaban and less adherence to apixaban.
Carbon footprint of healthcare systems: a systematic review of evidence and methods
Authors: Keil Mattis , Frehse Leonie , Hagemeister Marco , Knieß Mona , Lange Oliver , Kronenberg Tobias , Rogowski Wolf 
Published: April 2024

ObjectiveGiven the demand for net-zero healthcare, the carbon footprint (CF) of healthcare systems has attracted increasing interest in research in recent years. This systematic review investigates the results and methodological transparency of CF calculations of healthcare systems. The methodological emphasis lies specifically on input–output based calculations.DesignSystematic review according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guideline.Data sourcesPubMed, Web of Science, EconBiz, Scopus and Google Scholar were initially searched on 25 November 2019. Search updates in PubMed and Web of Science were considered until December 2023. The search was complemented by reference tracking within all the included studies.Eligibility criteriaWe included original studies that calculated and reported the CF of one or more healthcare systems. Studies were excluded if the specific systems were not named or no information on the calculation method was provided.Data extraction and synthesisWithin the initial search, two independent reviewers searched, screened and extracted information from the included studies. A checklist was developed to extract information on results and methodology and assess the included studies’ transparency.Results15 studies were included. The mean ratio of healthcare system emissions to total national emissions was 4.9% (minimum 1.5%; maximum 9.8%), and CFs were growing in most countries. Hospital care led to the largest relative share of the total CF. At least 71% of the methodological items were reported by each study.ConclusionsThe results of this review show that healthcare systems contribute substantially to national carbon emissions, and hospitals are one of the main contributors in this regard. They also show that mitigation measures can help reduce emissions over time. The checklist developed here can serve as a reference point to help make methodological decisions in future research reports as well as report homogeneous results.
Feasibility study of rehabilitation for cardiac patients aided by an artificial intelligence web-based programme: a randomised controlled trial (RECAP trial)—a study protocol
Authors: Witharana Pasan , Chang Lisa , Maier Rebecca , Ogundimu Emmanuel , Wilkinson Christopher , Athanasiou Thanos , Akowuah Enoch 
Published: April 2024

IntroductionCardiac rehabilitation (CR) delivered by rehabilitation specialists in a healthcare setting is effective in improving functional capacity and reducing readmission rates after cardiac surgery. It is also associated with a reduction in cardiac mortality and recurrent myocardial infarction. This trial assesses the feasibility of a home-based CR programme delivered using a mobile application (app).MethodsThe Rehabilitation through Exercise prescription for Cardiac patients using an Artificial intelligence web-based Programme (RECAP) randomised controlled feasibility trial is a single-centre prospective study, in which patients will be allocated on a 1:1 ratio to a home-based CR programme delivered using a mobile app with accelerometers or standard hospital-based rehabilitation classes. The home-based CR programme will employ artificial intelligence to prescribe exercise goals to the participants on a weekly basis. The trial will recruit 70 patients in total. The primary objectives are to evaluate participant recruitment and dropout rates, assess the feasibility of randomisation, determine acceptability to participants and staff, assess the rates of potential outcome measures and determine hospital resource allocation to inform the design of a larger randomised controlled trial for clinical efficacy and health economic evaluation. Secondary objectives include evaluation of health-related quality of life and 6 minute walk distance.Ethics and disseminationRECAP trial received a favourable outcome from the Berkshire research ethics committee in September 2022 (IRAS 315483).Trial results will be made available through publication in peer-reviewed journals and presented at relevant scientific meetings.Trial registration numberISRCTN97352737.
Risk of severe mood and anxiety disorders in the adult children of parents with alcohol use disorder: a nationwide cohort study
Authors: Kane Kimberly , Westman Jeanette , Franck Johan , Gissler Mika 
Published: April 2024

BackgroundGrowing up with parental alcohol use disorder (AUD) is a risk factor for psychiatric disorders. This study investigated the risk of mood disorders and of anxiety disorders in the adult children of parents with AUD, adjusted for sociodemographic factors.MethodsIndividual-level register data on the total population were linked to follow children of parents with AUD from 1973 to 2018 to assess their risk of mood disorders and of anxiety disorders. AUD, mood disorders and anxiety disorders were defined with International Statistical Classification of Diseases and Related Health Problems codes from the National Patient Register. HRs of outcomes were calculated with Cox regression. Model 1 was adjusted for the child’s sex, parental education and death of a parent. Model 2 was adjusted for those factors and parental diagnosis of mood or anxiety disorder.ResultsThose with ≥1 parent with AUD (99 723 of 2 421 479 children) had a higher risk of mood disorder and of anxiety disorder than those whose parents did not have AUD (HR mood 2.32, 95% CI 2.26 to 2.39; HR anxiety 2.66, 95% CI 2.60 to 2.72). The risk remained elevated after adjustment for sociodemographic factors and parental psychiatric diagnosis (HR mood 1.67, 95% CI 1.63 to 1.72; HR anxiety 1.74, 95% CI 1.69 to 1.78). The highest risks were associated with AUD in both parents, followed by AUD in mothers and then in fathers.ConclusionAdult children of parents with AUD have a raised risk of mood and anxiety disorders even after adjustment for sociodemographic factors and parental mood or anxiety disorder. These population-level findings can inform future policies and interventions.
Hybrid quantum-classical systems: Quasi-free Markovian dynamics
Authors: Barchielli Alberto , Werner Reinhard F. 
Published: April 2024

In the case of a quantum-classical hybrid system with a finite number of degrees of freedom, the problem of characterizing the most general dynamical semigroup is solved, under the restriction of being quasi-free. This is a generalization of a Gaussian dynamics, and it is defined by the property of sending (hybrid) Weyl operators into Weyl operators in the Heisenberg description. The result is a quantum generalization of the Lévy–Khintchine formula; Gaussian and jump contributions are included. As a byproduct, the most general quasi-free quantum-dynamical semigroup is obtained; on the classical side the Liouville equation and the Kolmogorov–Fokker–Planck equation are included. As a classical subsystem can be observed, in principle, without perturbing it, information can be extracted from the quantum system, even in continuous time; indeed, the whole construction is related to the theory of quantum measurements in continuous time. While the dynamics is formulated to give the hybrid state at a generic time [Formula: see text], we show how to extract multi-time probabilities and how to connect them to the quantum notions of positive operator-valued measure and instrument. The structure of the generator of the dynamical semigroup is analyzed, in order to understand how to go on to non-quasi-free cases and to understand the possible classical-quantum interactions; in particular, all the interaction terms which allow to extract information from the quantum system necessarily vanish if no dissipation is present in the dynamics of the quantum component. A concrete example is given, showing how a classical component can input noise into a quantum one and how the classical system can extract information on the behavior of the quantum one.
Pretty good measurement for bosonic Gaussian ensembles
Authors: Mishra Hemant K. , Lami Ludovico , Mandayam Prabha , Wilde Mark M. 
Published: April 2024

The pretty good measurement is a fundamental analytical tool in quantum information theory, giving a method for inferring the classical label that identifies a quantum state chosen probabilistically from an ensemble. Identifying and constructing the pretty good measurement for the class of bosonic Gaussian states is of immediate practical relevance in quantum information processing tasks. Holevo recently showed that the pretty good measurement for a bosonic Gaussian ensemble is a bosonic Gaussian measurement that attains the accessible information of the ensemble [IEEE Trans. Inf. Theory 66(9) (2020) 5634]. In this paper, we provide an alternate proof of Gaussianity of the pretty good measurement for a Gaussian ensemble of multimode bosonic states, with a focus on establishing an explicit and efficiently computable Gaussian description of the measurement. We also compute an explicit form of the mean square error of the pretty good measurement, which is relevant when using it for parameter estimation. Generalizing the pretty good measurement is a quantum instrument, called the pretty good instrument. We prove that the post-measurement state of the pretty good instrument is a faithful Gaussian state if the input state is a faithful Gaussian state whose covariance matrix satisfies a certain condition. Combined with our previous finding for the pretty good measurement and provided that the same condition holds, it follows that the expected output state is a faithful Gaussian state as well. In this case, we compute an explicit Gaussian description of the post-measurement and expected output states. Our findings imply that the pretty good instrument for bosonic Gaussian ensembles is no longer merely an analytical tool, but that it can also be implemented experimentally in quantum optics laboratories.