bluuebunny/crossref_metadata_2025_split huggingface dataset:
What Can Eye‐Trackers Visualize? — An Approach to Capture the Reality of Search Processes
Authors: Miwa Makiko , Erdelez Sanda , Lund Haakon , Gwizdka Jacek 
Published: January 2010

AbstractEye‐trackers have widely been used to judge whether user interfaces fit the searchers' cognitive style, but not often used to examine search processes. We have been using eye‐trackers to capture the behavior of people doing information searches on the web and attained an understanding of information search processes as cognitive processes with length and depth. We think eye‐trackers are useful for identifying various aspects of information search processes. In the past, eye‐trackers were quite expensive and required skill to use. Recently, however, less‐expensive and easy‐to‐use eye‐trackers have become available. Now it is possible to gather, compare, and contrast various research methods, findings, and implications about using eye‐trackers in behavior research particularly regarding web searches, in order to develop a firm foundation for future research.We would like to invite researchers from all over the globe who have been conducting a research using eye‐trackers for studying information seeking behaviors. Panel members' topics are as follows
On the challenges of implementing Library 2.0 services: A (diverse) panel discussion
Authors: Zimmer Michael , Corrado Edward , Ramirez Marisa , Reuter Kara , Rofofsky Marcus Sara , Saleh Nasser , Vaughan KT 
Published: January 2010

AbstractToday, many libraries are at a crossroads: several of the services they have traditionally provided within their walls are increasingly made available online, often by non‐library, commercial entities. For example, Web search engines provide easy access to millions of Websites, online databases provide convenient gateways to news and scholarship, and book‐scanning projects make roaming the shelves seem antiquated. Meanwhile, the traditional authority and expertise enjoyed by librarians has been challenged by the emergence of peer‐produced and collaborative knowledge projects, such as Wikipedia, Yahoo! Answers, or Amazon's personalized book recommendation system. Further, the professional, education, and social spheres of our lives are increasingly merging, marked by the rise of social networking services providing new interfaces for interacting with friends, the sharing of information, and professional collaboration.Libraries face a key question in this new environment: what is the role of the library in providing access to knowledge in today's digitally networked world? One answer has been to actively incorporate features of the online – “Web 2.0” – world into library services, thereby creating “Library 2.0.”Library 2.0 means bringing interactive, collaborative, user‐centered, and web‐based technologies to library services and collections. Launching such Library 2.0 features, however, often brings unique challenges to librarians, administrators, and patrons alike. These include: technological constraints, issues of accessibility and diversity, staffing and cost, IP/copyright concerns, privacy and data retention policies, and the overall impact on the nature and culture of the library itself.By bringing together a diverse collection of information professionals tasked with delivering Library 2.0 services, this panel discussion will outline many of the challenges of implementing Library 2.0, as well as illuminate some solutions and directions for the future. The goal of the panel is to help other information professionals navigate this uncharted terrain to foster the creation of innovative Library 2.0 services for their patrons, and reveal areas that require further attention by the profession and academia alike. This will be accomplished through guided conversation and sharing of ideas, not the traditional presentation of papers.
The DataNet partners: Sharing science, linking domains, curating data
Authors: Sandusky Robert J. , Palmer Carole L. , Allard Suzie , Cragin Melissa H. , Cruse Patricia , Renear Allen , Tenopir Carol 
Published: January 2010

AbstractThis panel introduces the first two DataNet partners funded through the National Science Foundation's Sustainable Digital Data Preservation and Access Network Partners (DataNet) solicitation (National Science Foundation, 2007). The first two of an expected five projects are The Data Conservancy: A Digital Research and Curation Virtual Organization, based at Johns Hopkins University (Sayeed Choudhury, PI), and DataONE: Observation Network for Earth, based at the University of New Mexico (William K. Michener, PI). Following a brief overview of NSF's DataNet vision and goals, each funded project will be introduced and positioned within the context of NSF's vision for the DataNet Partners. The next part of the panel will describe how information scientists and librarians are integrated into the projects, including research, educational, and service development objectives. The final part of the panel will discuss collaboration between the DataNet partners in order to serve as “elements of an interoperable data preservation and access network” (NSF, 2007).
Shared personal space: Meeting the needs of multiple users and multiple purposes
Authors: Barreau Deborah , Teevan Jaime 
Published: January 2010

AbstractInteresting things happen at the edges of our personal workspaces, where our own space butts up against that of others. This panel will focus on the challenges of sharing workspaces – with our families, with our colleagues, and with ourselves across roles, tasks, and locations. In keeping with the conference theme, Thriving on Diversity, the panel will explore both the benefits and challenges of shared workspace.
Image indexing and retrieval: Current projects and a comprehensive research agenda for the future
Authors: Jorgensen Corinne , Beaudoin Joan E. , Ménard Elaine , Neal Diane , Stvilia Besiki 
Published: January 2010

AbstractThis panel focuses on the major research questions needing further exploration in the areas of image organization, retrieval, and use. The panel will first have short presentations on several ongoing image research projects and presenters will briefly comment on their current research, new tools and approaches to image indexing, and the broader research areas they address. The panel will then move into an interactive mode and the moderator will present a brief outline of a broad‐based image research agenda for panel/audience dialogue, through which the agenda will be expanded and refined. In particular, current research in image indexing and retrieval focuses on the conference topic of “Thriving on Diversity – Information Opportunities in a Pluralistic World” as many newer tools (e.g., geotagging) and many new voices are joining in the image description process. The brief presentations relate to topics now appearing in the image indexing literature: information and knowledge behavior in diverse contexts, social networking in a linguistically and culturally rich environment, and challenges of harmony versus hegemony, as well as quality and relevance to particular audiences.
An analysis of formally published usability and Web usability definitions
Authors: Chen Yu‐Hui , Germain Carol Anne , Rorissa Abebe 
Published: January 2010

AbstractUsability in general and web usability in particular are complex concepts with multiple dimensions and elements/attributes. What is more, there is no comprehensive definition that takes into account the varying aspects of usability. This leads to discrepancies in policies/standards/guidelines which facilitate good usability practices. To initially address this problem, we took the first step of systematically analyzing the terms represented in formally published definitions from a number of sources in the subject areas of library & information science and computer science/information systems. Our results reveal that there are approximately 11 elements/attributes of usability and web usability addressed within these sources. The top five attributes are: learnability, effectiveness, user‐related attributes, users' attitude/satisfaction, and efficiency. However, other critical usability attributes received little to no attention in publications of either discipline.
Phytate in foods and significance for humans: Food sources, intake, processing, bioavailability, protective role and analysis
Authors: Schlemmer Ulrich , Frølich Wenche , Prieto Rafel M. , Grases Felix 
Published: January 2010

AbstractThe article gives an overview of phytic acid in food and of its significance for human nutrition. It summarises phytate sources in foods and discusses problems of phytic acid/phytate contents of food tables. Data on phytic acid intake are evaluated and daily phytic acid intake depending on food habits is assessed. Degradation of phytate during gastro‐intestinal passage is summarised, the mechanism of phytate interacting with minerals and trace elements in the gastro‐intestinal chyme described and the pathway of inositol phosphate hydrolysis in the gut presented. The present knowledge of phytate absorption is summarised and discussed. Effects of phytate on mineral and trace element bioavailability are reported and phytate degradation during processing and storage is described. Beneficial activities of dietary phytate such as its effects on calcification and kidney stone formation and on lowering blood glucose and lipids are reported. The antioxidative property of phytic acid and its potentional anticancerogenic activities are briefly surveyed. Development of the analysis of phytic acid and other inositol phosphates is described, problems of inositol phosphate determination and detection discussed and the need for standardisation of phytic acid analysis in foods argued.
Green tea polyphenols improve cardiac muscle mRNA and protein levels of signal pathways related to insulin and lipid metabolism and inflammation in insulin‐resistant rats
Authors: Qin Bolin , Polansky Marilyn M. , Harry Dawson , Anderson Richard A. 
Published: January 2010

AbstractEpidemiological studies indicate that the consumption of green tea polyphenols (GTP) may reduce the risk of coronary artery disease. To explore the underlying mechanisms of action at the molecular level, we examined the effects of GTP on the cardiac mRNA and protein levels of genes involved in insulin and lipid metabolism and inflammation. In rats fed a high‐fructose diet, supplementation with GTP (200 mg/kg BW daily dissolved in distilled water) for 6 wk, reduced systemic blood glucose, plasma insulin, retinol‐binding protein 4, soluble CD36, cholesterol, triglycerides, free fatty acids and LDL‐C levels, as well as the pro‐inflammatory cytokines, tumor necrosis factor‐α (TNF‐α) and IL‐6. GTP did not affect food intake, bodyweight and heart weight. In the myocardium, GTP also increased the insulin receptor (Ir), insulin receptor substrate 1 and 2 (Irs1 and Irs2), phosphoinositide‐3‐kinase (Pi3k), v‐akt murine thymoma viral oncogene homolog 1 (Akt1), glucose transporter 1 and 4 (Glut1 and Glut4) and glycogen synthase 1 (Gys1) expression but inhibited phosphatase and tensin homolog deleted on chromosome ten (Pten) expression and decreased glycogen synthase kinase 3β (Gsk3β) mRNA expression. The sterol regulatory element‐binding protein‐1c (Srebp1c) mRNA, microsomal triglyceride transfer protein (Mttp) mRNA and protein, Cd36 mRNA and cluster of differentiation 36 protein levels were decreased and peroxisome proliferator‐activated receptor (Ppar)γ mRNA levels were increased. GTP also decreased the inflammatory factors: Tnf, Il1b and Il6 mRNA levels, and enhanced the anti‐inflammatory protein, zinc‐finger protein, protein and mRNA expression. In summary, consumption of GTP ameliorated the detrimental effects of high‐fructose diet on insulin signaling, lipid metabolism and inflammation in the cardiac muscle of rats.
Empirical and DFT GIAO quantum‐mechanical methods of 13C chemical shifts prediction: competitors or collaborators?
Authors: Elyashberg Mikhail , Blinov Kirill , Smurnyy Yegor , Churanova Tatiana , Williams Antony 
Published: January 2010

AbstractThe accuracy of 13C chemical shift prediction by both DFT GIAO quantum‐mechanical (QM) and empirical methods was compared using 205 structures for which experimental and QM‐calculated chemical shifts were published in the literature. For these structures, 13C chemical shifts were calculated using HOSE code and neural network (NN) algorithms developed within our laboratory. In total, 2531 chemical shifts were analyzed and statistically processed. It has been shown that, in general, QM methods are capable of providing similar but inferior accuracy to the empirical approaches, but quite frequently they give larger mean average error values. For the structural set examined in this work, the following mean absolute errors (MAEs) were found: MAE(HOSE) = 1.58 ppm, MAE(NN) = 1.91 ppm and MAE(QM) = 3.29 ppm. A strategy of combined application of both the empirical and DFT GIAO approaches is suggested. The strategy could provide a synergistic effect if the advantages intrinsic to each method are exploited. Copyright © 2010 John Wiley & Sons, Ltd.
Characterization of Spetex‐1, a new component of satellite fibrils associated with outer dense fibers in the middle piece of rodent sperm flagella
Authors: Kaneko Takane , Murayama Emi , Kurio Hitoshi , Yamaguchi Akihiko , Iida Hiroshi 
Published: January 2010

AbstractSpetex‐1, which has been isolated by differential display as a haploid spermatid‐specific gene, encodes a protein with two coiled‐coil motifs located in the middle piece of flagella in rodent spermatozoa. The middle piece of flagella is composed of axoneme and peri‐axonemal elements including outer dense fibers (ODFs) and satellite fibrils. Pre‐embedding immunoelectron microscopy clearly demonstrated that Spetex‐1 is located at satellite fibrils associated with ODFs in the middle piece of flagella of rat spermatozoa. Extraction of Spetex‐1 from spermatozoa by SDS or urea required dithiothreitol, suggesting crosslinking by disulfide bond is involved in the assembly of satellite fibrils containing Spetex‐1. We identified putative Spetex‐1 orthologs in many animal species, and both cysteine residues and coiled‐coil motifs were well conserved in mammalian orthologs of Spetex‐1. When Spetex‐1 was co‐transfected into COS‐7 cells with myc‐tagged Tektin4, another filamentous protein associated with ODFs, the two molecules were co‐localized in various sizes of aggregates in the cells. These data suggested that Spetex‐1, a new component of satellite fibrils, might be involved in the structural stability of the sperm flagellar middle piece and functions in co‐operation with Tektin4. Mol. Reprod. Dev. 77: 363–372, 2010. © 2010 Wiley‐Liss, Inc.
The life and times of Dr David M. Young, Jr
Authors: Kincaid David R. , Varga Richard S. , Warlick Charles H. 
Published: January 2010

AbstractProfessor David M. Young, Jr was instrumental in the development of iterative algorithms and software for solving large sparse systems of linear algebraic equations of the type that typically arise in the numerical solution of partial differential equations. We present a brief overview of his life, accomplishments, and research. Copyright © 2010 John Wiley & Sons, Ltd.
Access to specialized pediatric cancer care in Switzerland
Authors: Adam Martin , Weid Nicolas von der , Michel Gisela , Zwahlen Marcel , Lutz Jean‐Michel , Probst‐Hensch Nicole , Niggli Felix , Kuehni Claudia ,   for the Swiss Pediatric Oncology Group (SPOG),   and for the Swiss Association of Cancer Registries (ASRT)
Published: January 2010

AbstractBackgroundSpecialized pediatric cancer centers (PCCs) are thought to be essential to obtain state‐of‐the‐art care for children and adolescents. We determined the proportion of childhood cancer patients not treated in a PCC, and described their characteristics and place of treatment.ProcedureThe Swiss Childhood Cancer Registry (SCCR) registers all children treated in Swiss PCCs. The regional cancer registries (covering 14/26 cantons) register all cancer patients of a region. The children of the SCCR with data from 7 regions (11 cantons) were compared, using specialized software for record linkage. All children <16 years of age at diagnosis with primary malignant tumors, diagnosed between 1990 and 2004, and living in one of these regions were included in the analysis.Results22.1% (238/1,077) of patients recorded in regional registries were not registered in the SCCR. Of these, 15.7% (169/1,077) had never been in a PCC while 6.4% (69/1,077) had been in a PCC but were not registered in the SCCR, due to incomplete data flow. In all diagnostic groups and in all age groups, a certain proportion of children was treated outside a PCC, but this proportion was largest in children suffering from malignant bone tumors/soft tissue sarcomas and from malignant epithelial neoplasms, and in older children. The proportion of patients treated in a PCC increased over the study period (P < 0.0001).ConclusionsOne in six childhood cancer patients in Switzerland was not treated in a PCC. Whether these patients have different treatment outcomes remained unclear. Pediatr Blood Cancer 2010;54:721–727. © 2010 Wiley‐Liss, Inc.
Comparison of proteomic biomarker panels in urine and serum for ovarian cancer diagnosis
Authors: Petri Anette Lykke , Simonsen Anja Hviid , Høgdall Estrid , Christensen Ib Jarle , Kjaer Susanne Krüger , Yip Christine , Risum Signe , Pedersen Anette Tønnes , Hartwell Dorte , Fung Eric T. , Høgdall Claus 
Published: January 2010

AbstractPurpose: The purposes of this study were to confirm previously found candidate epithelial ovarian cancer biomarkers in urine and to compare a paired serum biomarker panel and a urine biomarker panel from the same study cohort with regard to the receiver operating characteristic curve (ROC) area under the ROC curve (AUC) values.Experimental design: Four significant urine biomarkers were confirmed among 130 pelvic mass patients in the present study. The four biomarkers form a potential urine biomarker panel. From the same study cohort, the potential urine biomarker panel was compared to a serum biomarker panel, consisting of seven proteins/peptides, OvaRI.Results: Multivariate analysis of the urine panel demonstrated a significant differentiation (p<0.0001) between epithelial ovarian cancer patients and patients with benign ovarian pelvic masses.The ROC AUC of the urine panel was 0.84 and the ROC AUC of OvaRI was 0.83. Combining the urine panel with OvaRI demonstrated a significant contribution from both, for urine peaks, OR=2.12 and for OvaRI, OR=1.39; the ROC AUC of this model was 0.88.Conclusions and clinical relevance: We demonstrated that both urine and serum can be used individually or in combination to potentially aid in ovarian cancer diagnostics. Urine proteomic profiling could provide biomarkers for the non‐invasive test required in clinical practice.
Determining the Vapor Pressures of Diacetone Diperoxide (DADP) and Hexamethylene Triperoxide Diamine (HMTD)
Authors: Oxley Jimmie C. , Smith James L. , Luo Wei , Brady Joseph 
Published: January 2010

AbstractThe vapor signature of diacetone diperoxide (DADP) and hexamethylene triperoxide diamine (HMTD) were examined by a gas chromatography (GC) headspace technique over the range of 15 to 55 °C. Parallel experiments were conducted to redetermine the vapor pressures of 2,4,6‐trinitrotoluene (TNT) and triacetone triperoxide (TATP). The TNT and TATP vapor pressures were in agreement with the previously reported results. Vapor pressure of DADP was determined to be 17.7 Pa at 25 °C, which is approximately 2.6 times higher than TATP at the same temperature. The Clapeyron equation, relating vapor pressure and temperature, was LnP (Pa)=35.9−9845.1/T (K) for DADP. Heat of sublimation, calculated from the slope of the line for the Clapeyron equation, was 81.9 kJ mole−1. HMTD vapor pressure was not determined due to reduced thermal stability resulting in vapor phase decomposition products.
Study of peripheral muscle strength and severity indexes in individuals with chronic obstructive pulmonary disease
Authors: Marino Diego Marmorato , Marrara Kamilla Tays , Ike Daniela , De Oliveira Antônio Delfino , Jamami Maurício , Di Lorenzo Valéria Amorim Pires 
Published: January 2010

AbstractBackground and Purpose. Individuals with chronic obstructive pulmonary disease (COPD) present reduced peripheral muscle strength, which leads to impaired mobility and increased mortality risk. However, it is not clear whether there is any relationship between muscle strength, muscle mass and the body mass index, airflow obstruction, dyspnea, exercise performance (BODE) index scale, which is considered to be the best predictor of survival for individuals with COPD. The BODE Index is a multidimensional system that measures body composition (B), airway obstruction (O), dyspnea perception (D) and the ability to exercise (E), and rates the severity of the major changes found in individuals with COPD. The objective of this study was to verify any relationship between the BODE Index, muscle mass and maximum muscle strengths of the upper limb (UL) and lower limb (LL) in subjects with moderate to very severe COPD. Methods. Twenty‐six individuals with moderate to very severe COPD were evaluated by body composition (body mass index and muscle mass), BODE Index, handgrip strength (HS) and one repetition maximum (1RM) test of the UL and LL. Results. There was a positive correlation (Pearson, p < 0.05) of peripheral muscle strength, evaluated by HS and 1RM (pectoral and triceps, round muscles and dorsal section, quadriceps), to muscle mass (0.74, 0.57, 0.74 and 0.62, respectively) and the distance walked in the six‐minute walking test (0.52, 0.50, 0.46 and 0.58, respectively), but no correlation of muscle strength was found to forced expiratory volume in one second to dyspnea or the BODE Index. Conclusion. In accordance with the results of this study, peripheral muscle strength as measured by HS and 1RM is not related to the severity indexes for COPD, unlike UL and LL muscle strength. Therefore, UL and LL measurements now have an additional importance in COPD evaluation. Copyright © 2010 John Wiley & Sons, Ltd.