bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing climate change impacts on water availability in southern Portugal using a daily sequential soil-water budget model
Authors: Nunes Martins Tiago , Oliveira Manuel Mendes , Portela Maria Manuela , Leitão Teresa Eira 
Published: May 2024

ABSTRACT

Climate change poses a significant threat to water resources in southern Portugal. To understand the potential impacts on surface and groundwater resources, this study employed a daily sequential soil-water budget model (BALSEQ) under two representative concentration pathway (RCP) scenarios, RCP 4.5 and 8.5, spanning the periods 2020–2060 and 2061–2100. An analysis of meteorological observations and EURO-CORDEX climate projections showed a decline in annual rainfall, particularly under RCP 8.5. Monthly rainfall patterns exhibited significant decreases occurring from March to June, while in December and January, rainfall is likely to increase in all RCP scenarios and respective time-windows. Potential evapotranspiration (PET) demonstrated an increase across all scenarios. BALSEQ model simulations showed a likely decrease in deep infiltration (Ip) and direct runoff (Ed) under both RCP scenarios. The river basins with the highest reductions in Ed and Ip are Mira, Barlavento, southern Guadiana, and Sotavento. For instance, Ed is projected to decrease by up to 87% in Guadiana (RCP 8.5 [2020–2060]). Similarly, Ip is projected to decrease by up to 60% in Sotavento (RCP 8.5 [2061–2100]). These findings highlight the need for adaptation and mitigation measures to preserve the region's water resources.
Construction of the water balance model for the Bontanga irrigation dam in Northern Ghana
Authors: Mwanga Eliafie , Shaibu Abdul-Ganiyu , Issaka Zakaria 
Published: May 2024

ABSTRACT

Freshwater resources are essential for the sustenance of all living things, for crop production and socio-economic activities. The objective of this study was to construct a water balance model aimed at optimizing reservoir management by analyzing variations in water availability in the reservoir. This model will help dam operators to adopt water allocation strategies, timing of water releases and storage decisions. An echo sounder was used to measure the depth of water. Crop water requirements were computed using FAO CROPWAT 8 software, and the InVEST-SDR model was used to estimate sediments exported downstream of the watershed. Model construction utilized multiple linear regression, and the results were tested at a level of significance α = 0.05. Model performance was evaluated using a coefficient of determination (R2) and the ratio of the root mean square error to the standard deviation of measured data (RSR). The results revealed a coefficient of determination (R2) of 0.743 and a ratio of the root mean square error to the standard deviation of measured data (RSR) of 0.67. The constructed model will provide essential information to stakeholders on drought preparedness and mitigation, including water conservation measures and the management of water releases during critical periods.
Carbapenem-resistant Enterobacterales in wastewater resources and healthy carriers: A survey in Iran
Authors: Khavandi Shabnam , Habibzadeh Nasrin , Hasani Kamal , Sardari Mehran , Arzanlou Mohsen 
Published: May 2024

ABSTRACT
The carbapenem-resistant Enterobacterales (CRE) pose a pressing public health concern. Here, we investigated the frequency of CRE bacteria, carbapenemase-encoding genes, and the molecular epidemiology of carbapenemase-resistant Escherichia coli in wastewater resources and healthy carriers in Iran. Out of 617 Enterobacterales bacteria, 24% were carbapenem-resistant. The prevalence of CRE bacteria in livestock and poultry wastewater at 34% and hospital wastewater at 33% was significantly higher (P ≤ 0.05) than those in healthy carriers and municipal wastewater at 22 and 17%, respectively. The overall colonization rate of CRE in healthy individuals was 22%. Regarding individual Enterobacterales species, the following percentages of isolates were found to be CRE: E. coli (18%), Citrobacter spp. (24%), Klebsiella pneumoniae (28%), Proteus spp. (40%), Enterobacter spp. (25%), Yersinia spp. (17%), Hafnia spp. (31%), Providencia spp. (21%), and Serratia spp. (36%). The blaOXA-48 gene was detected in 97% of CRE isolates, while the blaNDM and blaVIM genes were detected in 24 and 3% of isolates, respectively. The B2 phylogroup was the most prominent group identified in carbapenem-resistant E. coli isolates, accounting for 80% of isolates. High prevalence of CRE with transmissible carbapenemase genes among healthy people and wastewater in Iran underscores the need for assertive measures to prevent further dissemination.
Optimal scheduling of variable speed pumps with mixed integer linear programming
Authors: Janus Tomasz , Ulanicki Bogumil , Diao Kegong 
Published: May 2024

ABSTRACT

Mixed integer linear programming (MILP) has been gaining traction as a method for solving optimal pump scheduling problems in water distribution networks (WDNs). However, inclusion of variable speed pumps (VSPs) in MILP pump scheduling frameworks has not been given adequate treatment. This article addresses this gap by describing a methodology for formulating and solving optimal pump scheduling problems with VSPs using MILP and piece-linear approximations of network components. The methodology proceeds in four steps: (a) WDN simulation with initial pump schedule(s), (b) approximation of network components, including VSP, using linear and piece-linear functions around the chosen operating points, (c) formulation of a fully parameterised mixed integer linear programme, and (d) solution of the optimisation problem and WDN simulation with optimal pump schedule(s). The methodology is coded in MATLAB/OCTAVE and Python and is publicly available on GitHub. It was applied to solve a pump scheduling problem on a two variable speed pump single-tank network that allows the reader to easily understand how the methodology works and how it is applied in practice. The results show that the formulation is robust and the optimiser is able to return a globally optimal solution for a range of operating points.
Enhanced removal of nano-oil droplets utilizing polysilicate aluminum ferric (PSAF): Leveraging bridging and non-polar surface advantages
Authors: Liu Yadan , Zhou Yanjun , Su Hui , Gu Chao , Shangguan Botao , Yan Zhiyang , Qin Jinyi 
Published: May 2024

ABSTRACT

Hydraulic oil leaks during mechanical maintenance, resulting in flushing wastewater contaminated with dispersed nano-oil droplets. In this study, 75 mg L−1 of polysilicate aluminum ferric (PSAF) was stirred at 350 rpm and the optimal chemical oxygen demand (COD) removal was 71%. The increase of PSAF led to more hydrolysis of Fe, and 1,175 cm−1 hydroxyl bridged with negative oil droplets. At the same molar concentration, PSAF hydrolyzes cationic metals more rapidly than polymeric aluminum chloride (PAC). PSAF forms flocs of smaller complex structures with greater bridging. The Al–O and Si–O peaks occurred at 611 and 1,138 cm−1, indicating the formation of Si–O–Fe and Si–O–Al bonds on the flocs surface. Higher stirring speeds did not change the free energy of the flocs surface γTot, mainly because the decrease in the van der Waals force (γLW) offset the increase of Lewis acid–base force (γAB). Preserving the non-polar surface, in summary, owing to its bridging abilities and affinity for non-polar surfaces, PSAF demonstrates superior efficiency over PAC in capturing and removing oil droplets.
Synthesis, Characterization, and Antimicrobial Evaluation of Schiff Base-mixed
Ligand Complexes with Divalent Metal Ions Derived from Amoxicillin and
Vanillin/Nicotinamide
Authors: Bahry Manhel R. , Al-Noor Taghreed H. , Fardous Ali M. , Heydari Ahmad R. , Abdou Aly , Fayez Shaimaa , El-Shazly Mohamed , Saleh Na'il 
Published: May 2024

Introduction:
This study focuses on the development of novel antimicrobial agents. A Schiff base
ligand, 6-(2-(4-hydroxy-3-methoxybenzylideneamino)-2-(4-hydroxyphenyl)acetamido)-3,3-dimethyl-7-oxo-
4-thia-1-azabicyclo [3.2.0] heptane-2-carboxylic acid, synthesized through the condensation of amoxicillin
and vanillin in methanol, served as the foundation. Polydentate mixed ligand complexes were then formed by
reacting the Schiff base with metal ions (Fe(II), Co(II), Ni(II), Cu(II), and Zn(II)) and nicotinamide in specific
ratios.

Methods:
Characterization involved various techniques, such as 1H-NMR, FT-IR, UV-Vis, and elemental
analysis for the ligand, and Atomic Absorption, FT-IR, UV-Vis, magnetic susceptibility, and conductance
measurements for the Schiff base-metal ion complexes.

Results:
Quantum chemical features of both ligands and metal complexes were computed, refining their electronic
and molecular structures theoretically. Antimicrobial activity against Staphylococcus aureus, Escherichia
coli, Klebsiella pneumoniae, Salmonella typhi, Acinetobacter baumannii, and Pseudomonas aeruginosa
was assessed for the starting materials, ligands, and synthesized complexes, revealing significant effects on
certain species. In-silico binding modes with Escherichia coli (PDB ID: 5iq9) were determined through molecular
docking.

Conclusion:
This study underscores the potential applications of the Schiff base ligands and their metal complexes
in developing new antimicrobial agents.
Curcumin in Cancer Prevention: Insights from Clinical Trials and Strategies to
Enhance Bioavailability
Authors: Alam Shabaz , Lee Jaewon , Sahebkar Amirhossein 
Published: May 2024

Abstract:
Cancer remains a leading cause of death worldwide, and current cancer drugs often have high costs
and undesirable side effects. Additionally, the development of drug resistance can reduce their effectiveness
over time. Natural products have gained attention as potential sources for the treatment and prevention of various
diseases. Curcumin, an extract from turmeric (Curcuma longa), is a natural phenolic compound with diverse
pharmacological properties, including antioxidant, anti-inflammatory, antiviral, antibacterial, antifungal,
antiprotozoal, antidiabetic, antivenom, antiulcer, anticarcinogenic, antimutagenic, anticoagulant, and antifertility
activities. Given the increasing interest in curcumin for cancer prevention, this review aims to comprehensively
examine clinical trials investigating the use of curcumin in different types of cancer. Additionally, effective
techniques and approaches to enhance the bioavailability of curcumin are discussed and summarized. This
review article provides insights into the properties of curcumin and its potential as a future anticancer drug.
hdWGCNA and Cellular Communication Identify Active NK Cell
Subtypes in Alzheimer's Disease and Screen for Diagnostic Markers
through Machine Learning
Authors: Song Guobin , Wu Haoyang , Chen Haiqing , Zhang Shengke , Hu Qingwen , Lai Haotian , Fuller Claire , Yang Guanhu , Chi Hao 
Published: May 2024

Background:
Alzheimer's disease (AD) is a recognized complex and severe neurodegenerative
disorder, presenting a significant challenge to global health. Its hallmark pathological
features include the deposition of β-amyloid plaques and the formation of neurofibrillary tangles.
Given this context, it becomes imperative to develop an early and accurate biomarker model for
AD diagnosis, employing machine learning and bioinformatics analysis.

Methods:
In this study, single-cell data analysis was employed to identify cellular subtypes that exhibited
significant differences between the diseased and control groups. Following the identification
of NK cells, hdWGCNA analysis and cellular communication analysis were conducted to pinpoint
NK cell subset with the most robust communication effects. Subsequently, three machine
learning algorithms-LASSO, Random Forest, and SVM-RFE-were employed to jointly screen for
NK cell subset modular genes highly associated with AD. A logistic regression diagnostic model
was then designed based on these characterized genes. Additionally, a protein-protein interaction
(PPI) networks of model genes was established. Furthermore, unsupervised cluster analysis was
conducted to classify AD subtypes based on the model genes, followed by the analysis of immune
infiltration in the different subtypes. Finally, Spearman correlation coefficient analysis was utilized
to explore the correlation between model genes and immune cells, as well as inflammatory
factors.

Results:
We have successfully identified three genes (RPLP2, RPSA, and RPL18A) that exhibit a
high association with AD. The nomogram based on these genes provides practical assistance in diagnosing
and predicting patients' outcomes. The interconnected genes screened through PPI are intricately
linked to ribosome metabolism and the COVID-19 pathway. Utilizing the expression of
modular genes, unsupervised cluster analysis unveiled three distinct AD subtypes. Particularly
noteworthy is subtype C3, characterized by high expression, which correlates with immune cell infiltration
and elevated levels of inflammatory factors. Hence, it can be inferred that the establishment
of an immune environment in AD patients is closely intertwined with the heightened expression
of model genes.

Conclusion:
This study has not only established a valuable diagnostic model for AD patients but
has also delved deeply into the pivotal role of model genes in shaping the immune environment of
individuals with AD. These findings offer crucial insights into early AD diagnosis and patient management
strategies.
Management of Unilateral Impacted Maxillary Permanent Canine: A Case Report
Authors: Halim Himawan , Halim Ivan A. 
Published: May 2024

Introduction
The management of maxillary canine is very complex because it must be carefully planned and carried out as a team. The handling of impacted canine cases must be seen from a clinical and radiological point of view. Maxillary canine impaction can be caused by a lack of space or inadequate seed placement. The time to treat canine impaction is usually between the ages of 11 and 14.

Objective
The aim of this case report was to describe the management of an impacted maxillary left canine of a teenage girl. Successful treatment requires complete diagnostics, such as radiographs, good teamwork, and precise treatment planning of the dental team.

Case Report
An 11-year-old female patient with class I molar relationship, bimaxillary protrusive, and impacted left upper canine visited the clinic for orthodontic treatment. Extraction of four first premolars (bicuspids) was carried out, and exposure by the periodontist was completed on the maxillary left canine for the installation of a traction device (gold chain traction).

Conclusion
The appropriate timing, treatment plan, and proper surgical exposure preparation in handling this case produced optimal and ideal results.
High-Performance Cobalt Chalcogenides for Oxygen Reduction Reaction
Authors: Hazarika Kumar Kashyap , Goswami Chiranjita , Bharali Pankaj 
Published: May 2024

:
The oxygen reduction reaction (ORR) is vital to numerous energy conversion technologies, such as fuel cells and metal-air batteries. Moreover, to
enhance the overall efficacy and durability of these devices, it is crucial to develop catalysts that are both effective and economical. Among the
many explored catalyst materials, cobalt chalcogenides have attracted considerable interest due to their unique properties and exceptional ORR
performance. This review focuses on the synthesis methods, structural characteristics, and electrochemical performance of high-performance cobalt
chalcogenides as catalysts for the ORR. In addition, the influence of various synthetic parameters on the catalytic activity and stability of cobalt
chalcogenides is investigated. Also addressed are the effects of defects, doping, and surface modification on the ORR performance of cobalt
chalcogenides. In addition, the use of cobalt chalcogenides in practical fuel cell devices is discussed, along with their outstanding performance as
ORR catalysts in both acidic and alkaline environments. The durability and long-term stability of cobalt chalcogenides under severe operating
conditions are evaluated, indicating their potential commercial applications. Finally, the field of cobalt chalcogenides for ORR challenges and
prospects are outlined. This review proposes strategies for further enhancing their catalytic activity, selectivity, and durability, such as interface
engineering and synergistic combinations with other catalyst materials. For researchers working on the development of next-generation ORR
catalysts and the practical implementation of cobalt chalcogenides for sustainable energy applications, the insights garnered from this review are
invaluable.
Requirements for and Barriers to Rehabilitation Services for Children With Disabilities in Middle- and High-Income Countries: Scoping Review
Authors: Xie Yijun , Wu Jing , Li Yao , Liu Hui , Peng Yanyan , Zhou Ping , Sun Yizhou , Kang Luyan , Jiang Chenghua , Wu Hengjing 
Published: May 2024

Background
The rehabilitation of children with disabilities has received considerable attention from the United Nations. However, the state of rehabilitation services for children with disabilities worldwide remains far from optimistic, even in economically affluent middle- and high-income countries.

Objective
This scoping review aimed to identify the rehabilitation needs of children with disabilities and their barriers to rehabilitation services in middle- and high-income countries.

Methods
A systematic search was conducted using MEDLINE and Web of Science for papers published from January 2013 to December 2023. Studies were included if they were peer-reviewed, full-text articles related to children with disabilities, reporting on their access to rehabilitation services, and conducted in countries classified by the World Bank 2023 as middle- and high-income economies. Exclusion criteria included duplicates, unavailable full texts, and studies without distinct outcomes. A total of 27 studies were selected following PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, focusing on children, their families, or service providers.

Results
The suitability, availability, and affordability of rehabilitation services were identified as the major needs and barriers for children with disabilities in middle- and high-income countries. This included communication barriers, a need for more personnel and facilities, and the stagnation and inadequacy of economic subsidies.

Conclusions
Middle- and high-income countries have relatively well-established rehabilitation infrastructure and support systems. They are nevertheless insufficient for meeting the needs of children with disabilities. More attention should be paid to these issues to improve the well-being of children with disabilities. The data provided by this review can help raise awareness of rehabilitation needs and barriers at the policy level.
Can an Online Course, Life101: Mental and Physical Self-Care, Improve the Well-Being of College Students?
Authors: Jafari Mahtab 
Published: May 2024

Abstract
The COVID-19 pandemic has had a significant impact on the mental health of college students worldwide. As colleges shifted to online instruction, students faced disruptions and increased stressors, leading to a decline in mental health that appears to continue in the postpandemic era. To alleviate this problem, academic institutions have implemented various interventions to address mental health issues; however, many of these interventions focus on a single approach and lack diverse delivery methods. This viewpoint introduces the concept of a multimodal self-care online course, Life101: Mental and Physical Self-Care, and discusses the potential effectiveness of such an intervention in improving students’ well-being. The course combines evidence-based interventions and incorporates interactive lectures, workshops, and guest speakers. Pre- and postcourse surveys were conducted over a span of 4 academic terms to evaluate the impact of this course on the well-being and self-care practices of students. The survey data suggest positive outcomes in students taking Life101, including the adoption of healthier habits, reduced stress levels, and increased knowledge and practice of self-care techniques. Life101 represents a novel multimodality intervention to address the epidemic of mental health issues faced by students today. By implementing similar evidence-based multimodal didactic curricula across campuses, academic institutions may be able to better equip students to navigate challenges and promote their overall well-being.
EMBARK: A Randomized, Controlled Trial Comparing Three Approaches to Reducing Diabetes Distress and Improving HbA1c in Adults With Type 1 Diabetes
Authors: Hessler Danielle M. , Fisher Lawrence , Guzman Susan , Strycker Lisa , Polonsky William H. , Ahmann Andrew , Aleppo Grazia , Argento Nicholas B. , Henske Joseph , Kim Sarah , Stephens Elizabeth , Greenberg Katherine , Masharani Umesh 
Published: May 2024

OBJECTIVE
To compare the effectiveness of three interventions to reduce diabetes distress (DD) and improve HbA1c among adults with type 1 diabetes (T1D).

RESEARCH DESIGN AND METHODS
Individuals with T1D (n = 276) with elevated DD (a score &gt;2 on the total Type 1 Diabetes Distress Scale) and HbA1c (&gt;7.5%) were recruited from multiple settings and randomly assigned to one of three virtual group-based programs: 1) Streamline, an educator-led education and diabetes self-management program; 2) TunedIn, a psychologist-led program focused exclusively on emotional-focused DD reduction; or 3) FixIt, an integration of Streamline and TunedIn. Assessments of the primary outcomes of DD and HbA1c occurred at baseline and at 3, 6, and 12 months.

RESULTS
All three programs demonstrated substantive and sustained reductions in DD (Cohen’s d = 0.58–1.14) and HbA1c (range, −0.4 to −0.72) at 12-month follow-up. TunedIn and FixIt participants reported significantly greater DD reductions compared with Streamline participants (P = 0.007). Streamline and TunedIn participants achieved significantly greater HbA1c reductions than did FixIt participants (P = 0.006).

CONCLUSIONS
DD can be successfully reduced among individuals with T1D with elevated HbA1c using both the educational/behavioral and emotion-focused approaches included in the study. Although both approaches are associated with significant and clinically meaningful reductions in DD and HbA1c, TunedIn, the emotion-focused program, had the most consistent benefits across both DD and HbA1c. The study findings suggest the overall value of group-based, fully virtual, and time-limited emotion-focused strategies, like those used in TunedIn, for adults with T1D.