bluuebunny/crossref_metadata_2025_split huggingface dataset:
Demonstration of fusobacteria in eruptions of perioral dermatitis using the tape stripping toluidine blue (TSTB) method
Authors: Berardi Paride , Benvenuti Silvano , Genga Antonio , Cecchini Fabio 
Published: August 2010

AbstractBackground and design To dale the pathogenesis of perioral dermatitis has not been completely‐understood. The role of fusobacteria was postulated by some investigators during the 1970s and subsequently disputed by others, who failed to confirm the presence of these bacteria. In a 6‐year period we investigated 341 patients with various facial eruptions, using the tape stripping toluidine blue (TSTB) method. According 1.0 the first clinical diagnosis 70 patients presented perioral dermatitis and 271 other facial conditions, including seborrheic dermatitis, rosacea, acne, contact dermatitis and bacterial infections.Results Fusobacteria were found in 57 (81%) of the 70 patients with perioral dermatitis, and in 14 (5%) of the 271 with other conditions. When only the clinically typical, unquestionable cases were considered, the percentages were 95% and 0%, respectively.Conclusions Our data support the view that fusobacteria are possibly involved in the pathogenesis of perioral dermatitis.
Can segmental neurofibromatosis be considered a rare disease?
Authors: Calzavara‐Pinton Pier G. , Carlino Anna , Gavazzoni Remo , Zane. Cristina , Panfilis Giuseppe De 
Published: August 2010

Abstract‘True’ segmental neurofibromatosis (SNF) is characterized by the unilateral, segmental appearance of neurofibromas and/or ‘cafe au lait’ spots in the absence of genetic transmission. SNF is apparently rare: only 41 cases have been described since the first report by Crowe in 1956. However, the incidence of SNF is probably higher because more and more patients have been described in the last few years and several cases have been observed by single trained authors in a short time. In 1988 and 1989 we had described two patients affected by ‘true’ SNF. Now we report three additional patients observed in the last two years. ‘True’ SNF is considered to be a consequence of a post‐zygotic (hence non‐transmissible) mutational event but this hypothesis is not suitable for cases with segmental lesions matching deep systemic involvement, bilateral distribution of cutaneous lesions or genetic transmission. Additional reports, with careful investigations of both systemic involvement in SNF patients and apparently unaffected relatives and with long follow‐ups, will help clarify the genetics and the pathogenests of the disease.
Italian multicenter study⋆ on Epiquick®, Rapid Patch Test® and TRUE TestTM
Authors: Ayala F. , Balato N. , Lembo G. , Patruno C. , Angelini G. , Valsecchi R. , Tosti A. , Rivara G. , Pigatto P. , Seidenari S. , Lisi P. , Rafanelli A. , Saccabusi S. , Schena D. , Kokelj F. 
Published: August 2010

AbstractUsing 3 different ready‐to‐apply patch test systems (Epiquick®= EPI; Rapid Patch Test®= RPT; TRUE TestTM= TT), 316 patients sensitive to at least one allergen were studied in order to investigate the reproducibility of these tests in comparison with the Finn Chamber ®(FC) technique. Each patient was tested with a different ready‐to‐use system. Each test was compared to the same allergen applied with FC to either side of the upper back. Comparisons were made using EPI, RPT, and TT in 93 (183 tests), 119 (262 tests), and 104 (242 tests) patients respectively. When a positive test result occurred on only one side of the back, the concordance was defined as negative. Similarly, doubtful reactions on either side corresponding to positive or negative results were considered as non concordant. The concordance of positive reactions was 80.9% between the EPI and the FC technique, 77.5% between the RPT and the FC technique, and 72.3% between the TT and the FC technique. The frequency of questionable (+?) and irritant reactions (IR) was about the same for the different tests. Nevertheless, when comparing the positive reactions vs +?, IR, or negative reactions in paired tests, positive results were more frequently obtained with the FC technique. Our data suggest that the standard method with FC allows a better detection of contact allergy than the new ready‐to‐use systems tested in this study.
Cyclosporin A in chronic actinic dermatitis
Authors: Parodi A. , Gallo R. , Guarrera M. , Rebora A. 
Published: August 2010

AbstractTwo patients with chronic actinic dermatitis received considerable benefit from the administration of cyclosporin A. The drug was initially given at 5 mg/kg/day and then reduced to about 4 mg/kg/day. No side effects have been registered so far. The scanty literature is reviewed. Cyclosporin A may be a useful adjunct to the armamentarium in this difficult‐to‐manage disorder.
Acrokeratosis paraneoplastica (Bazex syndrome) and inappropriate antidiuretic hormone secretion associated with epidermoid and anaplastic bronchial cancer
Authors: Bazex J. , ElSayed F. , Cadilhac H. , Gorguet B. , Soulier M. , Durand D. 
Published: August 2010

AbstractA 54‐year‐old patient received medical consultation for an acrokeratosis paraneoplastica in association with antidiuretic syndrome that revealed a small cell epidermoid and anaplastic bronchial cancer. Treatment of the neoplasm by polychemotherapy with Adriblastine, Carboplastine and Vepeside rapidly cured the acrokeratosis. Similarly, the syndrome of inappropriate antidiuretic hormone secretion was also completely controlled by hydrous restriction and treatment with demeclocyeline. Our observation illustrates quite well the paraneoplastic aspect of acrokeratosis whose association with antidiuretic syndrome has been rarely reported.
Massive gastrointestinal strongyloidiasis following corticosteroid therapy presenting with erythroderma and generalised lymphadenopathy
Authors: Pec Juraj , Straka Stefan , Palencarova Mariana , Adamkov Marian , Michal Ladislav , Vestenieka Gabriela , Minarikova Eva 
Published: August 2010

AbstractA case of Strongyloides stercoralis hyperinfection is described in a retired miner with erythroderma and diabetes mellitus, in a prelymphoma stage, treated with corticosteroids. On admission the patient was excreting massive quantities of rhabditiform and filariform larvae of Strongyloides stercoralis and also parasite ova were detected in his stool. The authors assume the Strongyloidex Stercoratis was a case of hyperinfection despite the negative results of histological examination of biopsies taken from lesions on perianal and gluteal regions. In the patient's biochemical profile the shift of immunologic parameters to levels of immunodeficiency, high values of total IgE without eosinophilia, and high values of proteins were indicative of acute inflammation. The patient's condition included extensive loss of body mass (14 kg) and repeated attacks of bacterial infection of the skin associated with fever. The patient did not report any symptoms indicating disturbances of the gastrointestinal tract cither before or during treatment. After antiparasitic treatment the stool became parasitologically negative, and it remained negative also in follow‐up examinations, and the general condition of the patient improved. However, 6 months later the skin biopsy revealed a malignant lymphoma, mycosis fungoides.
Steatocystoma multiplex and eruptive vellus hair cyst
Authors: Ríos‐Buceta L. , Caballero M. Jones , Montañés M. Aragüés , Fernández J. Fraga , Díez A. Gareía 
Published: August 2010

AbstractBackground of study Steatocystoma multiplex (SM) and eruptive vellus hair cyst (EVHC). are both entities with similar clinical features, hut with important histological differences. In the last few years, several authors have reported examples of both cysts with mixed historical features, and have proposed the idea that the two conditions are related.Subjects We report here 3 cases, histological features of SM. EVHC, and the other presenting cysts with mixed histological findings.Conclusions The different histological findings in the cases reported support the idea that SM and EVHC are extremes of a spectrum
Cryotherapy in cases with leishmaniasis cutis
Authors: Memişoǧlu Hamdi Rifal , Kotogyan Agop , Acar Mehmet Alpaslan , Özpoyraz Metin , Uzun Soner 
Published: August 2010

AbstractAim/Objective To prove the effectiveness of cryotherapy in the treatment of leishmaniasis cutis in a large group of patients.Subjects Two hundred and sixty‐six lesions of 227 patients with leishmaniasis cutis.Methods Cryotherapy with a double freeze‐thaw cycle by a CS‐76 apparatus and liquid nitrogen.Results All lesions responded well with cosmetically acceptable scars. The recurrance rate was only 4%.Conclusion Cryotherapy is an effective method of treatment of leishmaniasis cutis.
Long‐term systemic therapy with dimethylfumarate and monoethylfumarate (Fumaderm®) in psoriasis
Authors: Thio H.B. , van der Schroeff J.G. , Nugteren‐Huying W.M. , Vermeer B.J. 
Published: August 2010

AbstractObjective The aim of this study was to assess the clinical efficacy of long‐term (> 6 months) oral fumarate maintenance treatment regimen and to determine its adverse effect profile.Background We previously showed the efficacy of oral fumarate treatment in psoriasis. However, little is known about long‐term maintenance therapy with oral fumarates. Because of concern about renal toxicity and/or other potentially hazardous adverse effects, their role in the long‐term management of psoriasis is still controversial and limited.Methods Clinical data and laboratory parameters of 83 psoriasis patients who were treated with oral fumarates during an uninterrupted period of 6 or more months, were collected and subsequently analysed.Results In 31 of the 83 patients the oral fumarate therapy was discontinued preliminarily (<6 months) because of intolerable adverse effects (9 patients), lack of clinical efficacy (16 patients), insurance refunding problems (4 patients) and lost to follow‐up (2 patients), A major improvement of the psoriasis was present in 41 of the 83 patients. Long‐term oral fumarate maintenance therapy was accompanied by subjective adverse effects, mainly flushing (28 patients) and gastrointestinal upset (15 patients) and by a relative lymphocytopenia (35 patients).Conclusion Oral fumarates are effective well tolerated drugs suitable for long‐term management of psoriasis. However, this systemic therapy still has to be considered experimental and should only be performed under strictly controlled conditions. The cause and the clinical relevance of the relative lymphocytopenia, which occurs in a high percentage of patients during long‐term oral fumarate maintenance treatment regimen are unknown and still have to be determined.
Drug‐induced pemphigus in a predisposed girl⋆
Authors: Ruocco Vincenzo , Satriano Rocco A. , Lombardi Maria Luisa 
Published: August 2010

AbstractA 10‐year‐oId‐girl, with an atopic background and with certain pemphigus‐prone antigens in her HLA haplotype (DR4, w6; DQwl. w3), developed pemphigus foliaceus while on treatment with feprazone for an acute bout of pharyngitis. The diagnosis of pemphigus was confirmed by cyto‐histologic and immunofluorescence studies. The inducing role of feprazone was supported by a positive MFF test to the drug. The conventional steroid treatment cleared up all lesions in lour weeks. One year later, in absence of any therapy, the patient is well, but pemphigus antibodies are still present in her serum. Interestingly, a second‐degree aunt of the patient, genetically unrelated to her, suffered from pemphigus vulgaris triggered by feprazone.
Ultrasonic therapy for psoriasis
Authors: Clark Adele R. , Feldman Steven R. , Jorizzo Joseph L. 
Published: August 2010

AbstractUltrasound waves are routinely used in various fields of medicine. Ultrasonic cleaning involves the therapeutic application of ultrasound via an aqueous medium. Low frequency ultrasonic debridement and cleaning may be beneficial in the treatment of chronic plaque psoriasis. The mechanism of action is unclear, but may be related to the stable cavitational effects induced by ultrasonic energy.
Cholinergic urticaria simulating aquagenic urticaria: A case report with lesions only occurring after contact with hot water
Authors: Zouboulis Christos C. , Blume Ulrike , Gollnick Harald , Orfanos Constantin E. 
Published: August 2010

AbstractA 20‐year‐otd female presented with a 3‐month history of urticaria induced by water. During evaluation she repeatedly developed disseminated, severely itching. 2 to 5 mm large, anemic wheals at the center of indistinctly marginated patches of erythema on the upper part of the body after hot showers, which disappeared within 30 min. This rush was maximally reproducible twice daily. Serum histamine increased from 100 ng/ml to 140 ng/ml 30 min after provocation of the eruption. No lesions occurred after vigorous exertion or cold showers. A cholinergic and not an aquagenic urticaria was diagnosed because (i) the eruption only occurred after hot showers and not after cold showers or exertion to sweating, and (ii) a refractory period was observed. Provocation tests for other types of urticaria were negative. Cetirizine, in an initial dosis of 10 mg/d. followed 1 h later by a hot shower as a hardening regimen, suppressed the urticarial eruption, however, recurrences occurred twice, immediately after discontinuation of the drug.
Prostate cancer metastatic to skin
Authors: Bellman Betty , Grossman Marc , Spitz Joel 
Published: August 2010

AbstractCutaneous metastases from adenocarcinoma of the prostate are uncommon despite prostate cancer being the second most common malignancy in the American male population. We report bright red “berry‐like” cutaneous metastases in a dermatomal distribution from adenocarcinoma of the prostate. The prostate origin of the adenocarcinoma was confirmed by immunohistochemical staining for prostate‐specific antigen.
A case of hemophagocytic syndrome associated with B‐cell lymphoma
Authors: Ando Iwao , Okitsu Hiroshi , Kukita Atsushi , Kishino Satoshi , Mizuguchi Kunio 
Published: August 2010

AbstractA rare case of hemophagocytic syndrome (HPS) associated with B‐cell lymphoma is reported. A 38‐year old female with dyspnea and fever developed a subcutaneous nodule with purpuric erythema on her right thigh and consulted our department on September 2, 1991. The histologic picture of this nodule revealed a dense infiltration of atypical lymphocytes into the dermis and subcutaneous tissue. A surface marker study of these atypical cells were CD22, CD74, and HLA‐DR positive, indicating a B‐cell origin for these cells. Normal histiocytes phagocyting erythrocytes were mixed with the infiltrating cells. The patient also had pericardial effusion, liver dysfunction, hepatosplenomegaly, and bleeding tendencies. The diagnosis was HPS associated with B‐cell lymphoma. She died of DIC on November 8, 1991.
Bleomycin‐induced flagellate dermatitis in AIDS patients with Kaposi's sarcoma
Authors: Nandwania R. , Money‐Kyrle J. , Hawkins D.A. , Staughton R.C.D. , Phillips R.H. 
Published: August 2010

AbstractObjective To describe and illustrate bleomycin‐induced cutaneous toxicity, which may present atypically in AIDS patients with Kaposi's sarcoma.Design and subjects Case note review of all AIDS patients receiving systemic chemotherapy in the preceding year.Setting Combined oncology and HIV out‐patient clinic at the Chelsea and Westminster Hospital in London.Outcome measured Cutaneous toxicity associated with intravenous bleomycin therapy.Results We report three cases of bleomycin‐induced flagellate dermatitis with atypical presentation of pruritic skin lesions after relatively low doses of bleomycin.Conclusions Bleomycin usage is increasing as an effective agent in the treatment of AIDS‐related Kaposi's sarcoma. Awareness that cytotoxic drugs may produce a range of unusual cutaneous adverse effects in this patient population is important for doctors of all specialities who treat HIV‐infected patients. The pathomechanism of flagellate dermatitis is discussed.
Syphilis incidence in West Saxony (Germany) between 1983 and 1992
Authors: Haustein Uwe‐F. 
Published: August 2010

AbstractBackground Classical sexually transmitted diseases, such as syphilis and gonorrhoea, have shown a marked reduction in incidence over the past decade in industrialised countries. A contrary trend was observed for syphilis in West Saxony.Methods Data compiled on the incidence of syphilis in West Saxony (1.4 Mill, population) from 1983 to 1992.Results The total number of patients notified with syphilis was 1509. The incidence increased between 1984 and 1984 by a factor of 7.7. Seventy one percent were clinically active, whereas 29% were in the latent stages.Conclusion Despite a relatively high level of the health care and strict reporting system, syphilis incidence increased. Reasons are discussed.
Increased prevalence of herpes viruses in high grade CIN and carcinoma of the cervix: the potential for synergistic effect⋆
Authors: Baldauf J‐J. , Dreyfus M. , Monlun E. , Ritter J. , Obert G. 
Published: August 2010

AbstractObjective To assess the prevalence of human papillomavirus (HPV) type 16 and 18, herpes simplex virus (HSV) and human cytomegalovirus (HCMV) in cervical biopsies in order to evaluate their relationship in cervical intraepithelial neoplasia (CIN) and cancer.Setting Colposcopy clinic; Service de Gynécologic‐Obstétrique I, Hôpital de Hautepierre. Hôpitaux Universities de Strasbourg and Laboratoire Commun ULP/Synthélabo et U74 INSERM. Institut de Virologie dc la Faculté de Medecine de Strasbourg, France.Subjects Forty‐two women with low grade and high grade CIN, twenty women with cervical squamous cancer and twenty‐two women with normal cervix assessed by cytological, colposcopical and histological analysis.Methods Viral DNA was detected by PCR technique in colposcopically directed biopsies.Results The prevalence of HPV16 and/or HPV18 with HSV and/or HCMV was significantly higher in cancers (25%) or high grade CIN (29%) than in normal cervices (0%). On the contrary, when only HPV DNA was found, there was no significant difference between cancers (3O%). high grade CIN (29%) and normal cervices (9%).Conclusions The results support the hypothesis of a role of herpes viruses (HSV and HCMV) as cofactors in cervical carcinogenesis.
Concurrent oral and genital infection with HPV DNA types 6 and 11 in a heterosexual male
Authors: Ward Kathleen A. , McKernan Sinead A. , Durnien Natalina N. , Dinsmore Wallace W. 
Published: August 2010

AbstractObjective Detection of HPV DNA in oral and genital lesions of a heterosexual male. 4 months after oral and vaginal intercourse with a woman with vulvar warts. Passible modes of acquisition of oral HPV infection in the male sexual partner are discussed.Setting Genitourinary Medicine clinic.Methods Polymerase chain reaction amplification of genomic DNA from oral and genital lesions. HPV DNA typing by dot blot hybridization.Results HPV DNA types 6 and 11 were identified in a polypoid tongue lesion and in a penile wart from the male sexual partner.Conclusions The acquisition of oral HPV infection in the male sexual partner may have resulted from genital‐oral HPV transfer, either by direct contact with vulvar warts or by digital self‐inoculation.
Treatment of 208 extensive basal cell carcinomas with Mohs micrographic surgery
Authors: Neumann H.A.M. , Krekels G.A.M. , Verhaegh M.E.J.M. 
Published: August 2010

AbstractAim With the rapidly increasing number of basal cell carcinomas in Europe, a close look at Mohs Micrographic Surgery (MMS) is timely.Subject We report the results of MMS in the Netherlands, as treatment for extensive basal cell carcinomas.Methods Patients (n= 198) with extensive basal cell carcinoma (n= 208) were treated with MMS. The mean follow up period was 6.4 years.Results Four of 208 BCCs recurred.Conclusions Considering a recurrence rate of only 2% for the treatment of extensive and mainly recurrent basal cell carcinomas, we suggest that MMS provides the best prospect for total tumour removal.
Anti‐HCV‐core specific IgM in porphyria cutanea tarda
Authors: Gandolfo Luciana D'Alessandro , Ameglio Franco , Biolcati Gianfranco , Pimpinelli Fulvia , Trento Elisabetta , Galante Marisa , Nardi Armando , Topi Giancarlo 
Published: August 2010

AbstractAim Analysis of the prevalence of scrum IgM antibodies directed against the HCV‐core antigen (HCV‐IgM) in patients with Porphyria cutanea tarda (PCT), taking into account the hepatic histological picture, liver biochemical markers and the PCI biochemical indices.Background Hepatic damage, especially that due to HCV infection, has been previously reported as a PCT trigger. HCV‐IgM reactivity, a marker of chronic HCV hepatitis, suggested to be related to active virus replication could also be related to the PCT clinical course.Methods Blood samples of 97 patients, previously analyzed for a panel of clinical, histological and laboratory variables, followed in our Centre for Porphyria. stored at ‐ 80°C, were available to be retrospectively assayed for anti‐HCV‐core IgM (HCV‐IgM. ELISA).Results 61% HCV‐IgM positivity was found, with no apparent significant relationship with the respective histological hepatitis classification. PCT remission phase, and PCT familiarity, when evaluated on overall patients. The levels of HCV‐IgM presented u peculiar behaviour when correlated to the serum AST values. In fact, there was a significant positive correlation in those with HCV‐IgM < 4 and a not significant, inverse correlation in the remaining group. These two groups showed other differences: the HCV‐IgM levels were correlated to histology, PCT remission and to the markers of liver disease (such as AST and ALT) only in the first group.Conclusion a relationship between IgM response, PCT activity and the underlying liver disease is suggested.