bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Synthesis and Cytotoxicity Evaluation of Biaryl‐Based Chalcones and Their Potential in TNFα‐Induced Nuclear Factor‐ϰB Activation Inhibition.
Authors: Zuo Yinglin , Yu Yi , Wang Shuni , Shao Weiyan , Zhou Binhua , Lin Li , Luo Zhuoyu , Huang Ruogo , Du Jun , Bu Xianzhang 
Published: August 2012

AbstractA variety of biaryl‐based chalcones are designed, synthesized and evaluated for their inhibitory activities against five cancer cell lines.
ChemInform Abstract: One‐Pot Synthesis of Amidoalkyl Naphthols Using POCl3/Na2B4O7 as a Heterogeneous Catalyst.
Authors: Jafari Hadi , Moghanian Hassan 
Published: August 2012

AbstractA convenient and efficient multicomponent procedure for the synthesis of 1‐amidoalkyl‐2‐naphthols under solvent‐free conditions is described.
ChemInform Abstract: Copper‐Catalyzed Skeletal Rearrangement of O‐Propargylic Aryloximes into Four‐Membered Cyclic Nitrones — Chirality Transfer and Mechanistic Insight.
Authors: Nakamura Itaru , Kudo Yu , Araki Toshiharu , Zhang Dong , Kwon Eunsang , Terada Masahiro 
Published: August 2012

AbstractThe cyclization process is investigated with respect to regio‐ and E/Z‐selectivity.
ChemInform Abstract: Palladium‐Catalyzed Synthesis of 4‐Oxaspiro[2.4]heptanes via Central Attack of Oxygen Nucleophiles to π‐Allylpalladium Intermediates.
Authors: Shintani Ryo , Ito Tomoaki , Hayashi Tamio 
Published: August 2012

AbstractTreatment of lactones of type (I) and (V) with aldehydes under conditions A) results in selective formation of 4‐oxaspiro[2.4]heptanes.
ChemInform Abstract: Three‐Component Reactions of Isocyanides, Dialkyl Acetylenedicarboxylates, and trans‐Cinnamoyl Chlorides for the Synthesis of Highly Functionalized 2‐Vinyl Furans.
Authors: Esmaeili Abbas Ali , Zangouei Mahdieh , Hosseinabadi Rahele , Fakhari Ali Reza 
Published: August 2012

Abstractas synthons for natural products and pharmaceutical substances
ChemInform Abstract: Ultrasound‐Assisted Bismuth Nitrate‐Induced Green Synthesis of Novel Pyrrole Derivatives and Their Biological Evaluation as Anticancer Agents.
Authors: Bandyopadhyay Debasish , Mukherjee Sanghamitra , Granados Jose C. , Short John D. , Banik Bimal K. 
Published: August 2012

AbstractTwo compounds, compounds (IIId) and (IIIe), show good cytotoxicity against some cancer cell lines and exhibit cytotoxic specificity against liver cancer cell lines in vitro when compared with cultured primary hepatocytes.
ChemInform Abstract: A Synthetic Approach to Diverse 3‐Acyltetramic Acids via O‐ to C‐Acyl Rearrangement and Application to the Total Synthesis of Penicillenol Series.
Authors: Sengoku Tetsuya , Nagae Yuta , Ujihara Yasuaki , Takahashi Masaki , Yoda Hidemi 
Published: August 2012

AbstractThe efficient route to various biologically important 3‐acyltetramic acids can be applied to prepare penicillenol A2 (XIII).
ChemInform Abstract: Asymmetric Allylic Alkylation of Pyrroles and 4,7‐Dihydroindoles with Alkene—Phosphine Ligands.
Authors: Liu Yilin , Cao Ziping , Du Haifeng 
Published: August 2012

AbstractUnder conditions A), isomerization of cis‐alkenes to trans isomers is observed.
ChemInform Abstract: A N‐Heterocyclic Carbene (NHC) Platinum Complex as Pre‐Catalyst for the Intramolecular Hydroamination of Olefins with Secondary Alkylamines and Oxidative Amination of ω‐Alkenic Amines.
Authors: Zhang Rui , Xu Qin , Mei Liang‐yong , Li Sheng‐ke , Shi Min 
Published: August 2012

AbstractThe novel complex (NHCPT) along with AgBF4 is a highly efficient system for the title reaction.
ChemInform Abstract: Highly Reactive meso‐Like Positions of Dipyrihexaphyrin.
Authors: Setsune Jun‐ichiro , Yamato Kyohei 
Published: August 2012

AbstractThe meso‐like positions in the pyridine‐containing porphyrin analogue (I), structurally related to amethyrin, are highly reactive towards addition of alcohols, amines, or cyanide.
ChemInform Abstract: One‐Pot, Pseudo Five‐Component Synthesis of Spirooxindole Derivatives Containing Fused 1,4‐Dihydropyridines in Water.
Authors: Alizadeh Abdolali , Mikaeili Azadeh , Firuzyar Tahereh 
Published: August 2012

AbstractThe reaction of nitroethylene (III) with ammonia generates a ketene diaminal intermediate which reacts with a Knoevenagel product, formed in situ from isatins and 1,3‐dicarbonyl compounds, to yield the title compounds.
ChemInform Abstract: Synthesis of 6H‐Isoindolo[2,1‐a]indol‐6‐ones Through a Sequential Copper‐Catalyzed C—N Coupling and Palladium‐Catalyzed C—H Activation Reaction.
Authors: He Hua‐Feng , Dong Sheng , Chen Yi , Yang Yang , Le Yueqin , Bao Weiliang 
Published: August 2012

AbstractThe one‐pot reaction comprises a copper‐catalyzed C—N coupling cyclization and a palladium‐catalyzed C—H activation course.
ChemInform Abstract: Facile, Novel Two‐Step Syntheses of Benzimidazoles, Bis‐benzimidazoles, and Bis‐benzimidazole‐dihydroquinoxalines.
Authors: Xu Zhigang , Shaw Arthur Y. , Dietrich Justin , Cappelli Alexandra P. , Nichol Gary , Hulme Christopher 
Published: August 2012

AbstractA series of title compounds is synthesized by a strategy which involves Ugi four‐component condensation of the isonitrile (I) followed by TFA‐mediated deprotection and cyclization.
ChemInform Abstract: Synthesis of Benzothiazoles Through Copper‐Catalyzed One‐Pot Three‐Component Reactions with Use of Sodium Hydrosulfide as a Sulfur Surrogate.
Authors: Park Namjin , Heo Yumi , Kumar Manian Rajesh , Kim Yong , Song Kwang Ho , Lee Sunwoo 
Published: August 2012

AbstractA variety of 2‐iodoanilines and aromatic/heteroaromatic aldehydes undergo the title reaction.
ChemInform Abstract: Alkyne—Azide Cycloaddition Catalyzed by Fe—Cu Nanoparticles.
Authors: Garcia‐Munoz Angel , Gonzalez Jaime , Trujillo‐Reyes Jessica , Morales‐Luckie Raul A. , Sanchez‐Mendieta Victor , Gonzalez Carlos , Fuentes Aydee , Cuevas‐Yanez Erick 
Published: August 2012

AbstractParamagnetic Fe—Cu nanoparticles are used to catalyze typical azide—alkyne cycloadditions.
ChemInform Abstract: New Triazole Derivatives as Antifungal Agents: Synthesis via Click Reaction, in vitro Evaluation and Molecular Docking Studies.
Authors: Zou Yan , Zhao Qingjie , Liao Jun , Hu Honggang , Yu Shichong , Chai Xiaoyun , Xu Mingjuan , Wu Qiuye 
Published: August 2012

AbstractA series of fluconazole analogues (I) is designed and synthesized using a click chemistry approach.
ChemInform Abstract: Design, Synthesis, Computational and Biological Evaluation of Some New Hydrazino Derivatives of DHA (III) and Pyrazopyrazoles (IV).
Authors: Kumar Ajay , Lohan Poonam , Aneja Deepak K. , Gupta Girish Kumar , Kaushik Dhirender , Prakash Om 
Published: August 2012

AbstractNew hydrazino derivatives of dehydroacetic acid (DHA) and their cyclic analogues (IV) are synthesized starting from 3‐acetyl‐4‐chloropyranone (I).
ChemInform Abstract: Facile Synthesis of 4‐Substituted 3,4‐Dihydrocoumarins via an Organocatalytic Double Decarboxylation Process.
Authors: Peng Shiyong , Wang Lei , Guo Haibing , Sun Shaofa , Wang Jian 
Published: August 2012

AbstractThe first organocatalytic double decarboxylation strategy for an efficient and convenient synthesis of the title compounds is presented.
ChemInform Abstract: Palladium‐Catalyzed Asymmetric 6‐endo Cyclization of Dienamides with Substituent‐Driven Activation.
Authors: Tsuchikawa Hiroshi , Maekawa Yuya , Katsumura Shigeo 
Published: August 2012

AbstractThe activation by the tosyl and the C‐3 ester function is essential for the cyclization.
ChemInform Abstract: Deprotonative Metalation of Aromatic Compounds Using Mixed Lithium—Iron Combinations.
Authors: Nagaradja Elisabeth , Chevallier Floris , Roisnel Thierry , Jouikov Viatcheslav , Mongin Florence 
Published: August 2012

AbstractThe electrophilic trapping with LiFe(TMP)3 affords mostly the desired product together with the 2,2‐dimer of the substrate.
ChemInform Abstract: Dihydropyridones: Catalytic Asymmetric Synthesis, N‐ to C‐Sulfonyl Transfer, and Derivatizations.
Authors: Simal Carmen , Lebl Tomas , Slawin Alexandra M. Z. , Smith Andrew D. 
Published: August 2012

AbstractA scalable addition reaction and the first example of a N‐ to C‐sulfonyl photoisomerization reaction of a dihydropyridone, cf.
ChemInform Abstract: A Concise Synthesis of Tetrahydroisoquinoline‐1‐carboxylic Acids Using a Petasis Reaction and Pomeranz—Fritsch—Bobbitt Cyclization Sequence.
Authors: Chrzanowska Maria , Grajewska Agnieszka , Meissner Zofia , Rozwadowska Maria , Wiatrowska Iwona 
Published: August 2012

AbstractThe sequence affords the target compounds in only 2 steps.
ChemInform Abstract: A Concise Synthesis of 6H‐Indolo[2,3‐b]quinolines: Formal Synthesis of Neocryptolepine.
Authors: Kadam Hari K. , Parvatkar Prakash T. , Tilve Santosh G. 
Published: August 2012

AbstractThe convenient two‐step approach to indoloquinolines (IV) proceeds via C‐3 alkylation of indoles (I) followed by a one‐pot reduction—cyclization—aromatization sequence.
ChemInform Abstract: Bis(imino)pyridine (BIMP) Fe(II) Catalyzes One‐Pot Green Condensation of Resorcinol, Malononitrile, Aromatic Aldehydes and Cyclohexanone.
Authors: Damavandi Saman , Sandaroos Reza 
Published: August 2012

AbstractTitle reaction proceeds smoothly under ultrasound irradiation and under solvent‐free conditions to give the tetracyclic pyrano[2,3‐b]pyridines (V) with excellent regioselectivity.
ChemInform Abstract: Prins Cyclization of Styrenes or Acetophenone Catalyzed by DBSA in Water.
Authors: Zhang Juan , Hua Lin , Li Feifei , Wu Xuefen , Tian Shengzhin , Yang Jing 
Published: August 2012

AbstractDodecylbenzenesulfonic acid (DBSA) is shown to be an efficient catalyst for the Prins cyclization of styrene derivatives with formaldehyde or acetaldehyde in water to give a variety of aryl‐substituted dioxane derivatives.
ChemInform Abstract: Use of (Z)‐β‐(2‐Fluorobenzenesulfonyl)vinylamines as Novel Synthons in the Synthesis of 1,4‐Benzothiazine Derivatives.
Authors: Tsui Gavin Chit , Singjunla Yuttapong , Lautens Mark 
Published: August 2012

AbstractThe Rh‐catalyzed reaction of fluorophenylsulfonyl acetonitriles with boronic acids gives vinylamines of type (V) which can be readily cyclized to 1,4‐benzothiazine 1,1‐dioxides (VI).
ChemInform Abstract: Design, Synthesis, in vitro Antimicrobial and Anticancer Activity of Novel Methylenebis‐isoxazolo[4,5‐b]azepines Derivatives.
Authors: Rajanarendar E. , Reddy M. Nagi , Krishna S. Rama , Reddy K. Govardhan , Reddy Y. N. , Rajam M. V. 
Published: August 2012

AbstractCompounds (IVe) and (IVf) exhibit potent antimicrobial and anticancer activities comparable to the standard drugs.
ChemInform Abstract: A New Pancreatic Lipase Inhibitor from Broussonetia kanzinoki.
Authors: Ahn Jong Hoon , Liu Qing , Lee Chul , Ahn Mi‐Jeong , Yoo Hwan‐Soo , Hwang Bang Yeon , Lee Mi Kyeong 
Published: August 2012

AbstractBroussonone A (I) shows inhibitory activity on pancreatic lipase and on adipocyte differentiation (3T3‐L1 cells).
Pyruvate kinase M2 is a novel diagnostic marker and predicts tumor progression in human biliary tract cancer
Authors: Dhar Dipok Kumar , Olde Damink Steven W.M. , Brindley James Hal , Godfrey Andrew , Chapman Michael H. , Sandanayake Neomal S. , Andreola Fausto , Mazurek Sybille , Hasan Tayyaba , Malago Massimo , Pereira Stephen P. 
Published: August 2012

AbstractBACKGROUND:The early diagnosis of biliary tract cancer (BTC) remains challenging, and there are few effective therapies. This study investigated whether the M2 isotype of pyruvate kinase (M2‐PK), which serves as the key regulator of cellular energy metabolism in proliferating cells, could play a role in the diagnosis and therapy of BTC.METHODS:Plasma and bile M2‐PK concentrations were measured by enzyme‐linked immunosorbent assay in 88 patients with BTC, 79 with benign biliary diseases, and 17 healthy controls. M2‐PK expression was assayed in a BTC tissue array by immunohistochemistry. The role of M2‐PK in tumor growth, invasion, and angiogenesis was evaluated in BTC cell lines by retrovirus‐mediated M2‐PK transfection and short hairpin RNA silencing techniques.RESULTS:Sensitivity (90.3%) and specificity (84.3%) of bile M2‐PK for malignancy were significantly higher than those for plasma M2‐PK and serum carbohydrate antigen 19‐9. M2‐PK expression was specific for cancer cells and correlated with microvessel density. M2‐PK positivity was a significant independent prognostic factor by multivariable analysis. Transfection of M2‐PK in a negatively expressed cell line (HuCCT‐1 cells) increased cell invasion, whereas silencing in an M2‐PK–positive cell line (TFK cells) decreased tumor nodule formation and cellular invasion. A significant increase in endothelial tube formation was noted when supernatants from M2‐PK–transfected cells were added to an in vitro angiogenesis assay, whereas supernatants from silenced cells negated endothelial tube formation.CONCLUSIONS:Bile M2‐PK is a novel tumor marker for BTC and correlates with tumor aggressiveness and poor outcome. Short hairpin RNA–mediated inhibition of M2‐PK indicates the potential of M2‐PK as a therapeutic target. Cancer 2013. © 2012 American Cancer Society.
Type 2 diabetes mellitus and survival in pancreatic adenocarcinoma
Authors: Hwang Allen , Narayan Vivek , Yang Yu‐Xiao 
Published: August 2012

AbstractBACKGROUND:Recent evidence has identified pre‐existing type 2 diabetes mellitus (T2DM) as a risk factor for the development of PAC, but relatively little is known about its effects on survival. Our aim was to determine the effect of varying durations of pre‐existing T2DM on survival in patients with PAC.METHODS:We conducted a retrospective cohort study using The Health Improvement Network (THIN), a primary care electronic medical record database from the UK (2003‐2010). The study cohort included all subjects with a diagnostic code for PAC. Subjects with a diagnostic code for T2DM before their PAC diagnosis were classified as exposed; otherwise, subjects were classified as unexposed. The primary outcome was overall survival. The analysis was performed using univariate and multivariable Cox proportional‐hazards models. Additional analysis was performed to assess the effect of increasing duration of pre‐existing T2DM [i.e., <90 days, 90 days to <1 year, 1 to <3 years, 3 to 5 years, >5 years] on survival.RESULTS:The study included 3,147 patients with PAC, with 745 patients having pre‐existing T2DM and 2,402 patients without pre‐existing T2DM. In the primary multivariate analysis, there was no difference in survival between those exposed and those unexposed to pre‐existing T2DM (HR 1.02 [0.93, 1.12], p = 0.620). In the secondary analysis, only those patients with T2DM > 5 years duration had a significantly increased mortality (HR 1.16 [1.00, 1.33], p < 0.05).CONCLUSIONS:Long‐term pre‐existing T2DM is associated with increased mortality in patients diagnosed with PAC. Cancer 2013. © 2012 American Cancer Society.
Modeling and biomechanical analysis of craniosynostosis correction with the use of finite element method
Authors: Wolański Wojciech , Larysz Dawid , Gzik Marek , Kawlewska Edyta 
Published: August 2012

SUMMARYCraniosynostosis is a skull malformation because of premature fusing of one or more cranial sutures. The most common types of craniosynostosis are scaphocephaly (with the sagittal suture fused) and trigonocephaly (with the metopic suture fused). In this paper we describe and discuss how finite element analysis and three‐dimensional modeling can be used for preoperative planning of the correction of craniosynostosis and for the postoperative evaluation of the treatment results. We used the engineering software MIMICS MATERIALISE to obtain three‐dimensional geometry from computed tomography scans, and applied finite element method for the sake of biomechanical analysis. These simulations help to improve the surgical treatment, making it more accurate, safer, and faster. Copyright © 2012 John Wiley & Sons, Ltd.
Contrast in Electron‐Transfer Mediation between Graphene Oxide and Reduced Graphene Oxide
Authors: Hongthani Wiphada , Patil Avinash J. , Mann Stephen , Fermín David J. 
Published: August 2012

AbstractThe properties of graphene oxide (GO) and DNA‐stabilised reduced graphene‐oxide (rGO) sheets as electron‐transfer mediators in partially blocked electrodes are evaluated employing electrochemical impedance spectroscopy. Evidences obtained from UV/Vis, Raman and FTIR spectroscopies, as well as atomic force microscopy, confirm that the reduction of exfoliated GO single sheets by hydrazine yields partially reduced graphene oxide featuring a high defect density. Two‐dimensional assemblies of GO and rGO were formed through electrostatic adsorption at Au electrodes, sequentially modified with 11‐mercaptoundecanoic acid (MUA) and poly‐diallyldimethylammonium chloride (PDADMAC). The MUA:PDADMAC generates a strong blocking layer to the electron‐transfer reaction involving the ferri/ferrocyanide redox couple. This blocking behaviour is not significantly affected upon adsorption of GO. However, adsorption of a sub‐monolayer of rGO decreases the charge‐transfer resistance by more than two orders of magnitude. Analysis of cyclic voltammograms and impedance spectra suggests that electron transfer in rGO assemblies is mediated by occupied states located just below the redox Fermi energy of the probe. These findings are discussed in the context of on‐going controversies regarding the electrochemical reactivity of sp2‐carbon basal planes.
Extended DNA Tile Actuators
Authors: Kristiansen Martin , Kryger Mille B. L. , Zhang Zhao , Voigt Niels V. , Birkedal Victoria , Gothelf Kurt V. 
Published: August 2012

AbstractA dynamic linear DNA tile actuator is expanded to three new structures of higher complexity. The original DNA actuator was constructed from a central roller strand which hybridizes with two piston strands by forming two half‐crossover junctions. A linear expansion of the actuator is obtained by fusing two actuators of different sequence designs with a third central roller strand. This structure spans 35 nm and its integrity was verified by PAGE analysis. Owing to sequence homology around the crossovers the actuator can obtain 12 different states. The states of the actuator are controlled by a lock strand inserted at one end of the actuator and monitored by Förster resonance energy transfer (FRET) spectroscopy between a fluorophore pair which is located at the other end of the actuator. Two other designs were made where the linear actuator monomer is expanded into two dimensions by forming triangular and quadrilateral actuators. This could be attained by extending the central roller to three or four repeated 32 nucleotide regions that are complementary to the same piston. The triangular and quadrilateral actuators were characterized by PAGE analysis and it was shown that they could be locked in states 0, 5, and 10 and furthermore that they could be switched between the different states by strand displacement reactions.
Modeling complex systems macroscopically: Case/agent‐based modeling, synergetics, and the continuity equation
Authors: Rajaram Rajeev , Castellani Brian 
Published: August 2012

AbstractRecently, the continuity equation (also known as the advection equation) has been used to study stability properties of dynamical systems, where a linear transfer operator approach was used to examine the stability of a nonlinear equation both in continuous and discrete time (Vaidya and Mehta, IEEE Trans Autom Control 2008, 53, 307–323; Rajaram et al., J Math Anal Appl 2010, 368, 144–156). Our study, which conducts a series of simulations on residential patterns, demonstrates that this usage of the continuity equation can advance Haken's synergetic approach to modeling certain types of complex, self‐organizing social systems macroscopically. The key to this advancement comes from employing a case‐based approach that (1) treats complex systems as a set of cases and (2) treats cases as dynamical vsystems which, at the microscopic level, can be conceptualized as k dimensional row vectors; and, at the macroscopic level, as vectors with magnitude and direction, which can be modeled as population densities. Our case‐based employment of the continuity equation has four benefits for agent‐based and case‐based modeling and, more broadly, the social scientific study of complex systems where transport or spatial mobility issues are of interest: it (1) links microscopic (agent‐based) and macroscopic (structural) modeling; (2) transforms the dynamics of highly nonlinear vector fields into the linear motion of densities; (3) allows predictions to be made about future states of a complex system; and (4) mathematically formalizes the structural dynamics of these types of complex social systems.
Coevolution of role preference and fairness in the ultimatum game
Authors: Ichinose Genki 
Published: August 2012

AbstractTraditional economics assumes that humans are rational. However, it is known that humans behave fairly in the ultimatum game (UG). There are various explanations for this apparent paradox, such as the “inequity aversion.” However, the role preference (proposer or responder) of humans in the UG is obscure. I conducted a UG scenario experiment where subjects were asked their role preference in addition to their decision in the game. The results showed that the subjects prefer to be proposers rather than responders. In particular, it was found that rational subjects had a high preference for the proposer role. On the basis of these results, I conducted evolutionary simulations of the UG, where each individual has role preference intensity. A role is allocated to the individual proportional to the preference intensity. The results showed coevolution of role preference and fairness. The preference for the proposer role evolved when rational strategy evolved, whereas this preference weakened as rationality decreased. This indicates that fairness has a strong link with role preference; in other words, human fairness is always threatened by the “power and position” of some particular individuals. Hence, its equal distribution among individuals may be effective in maintaining a high level of fairness. © 2012 Wiley Periodicals, Inc. Complexity, 2012
Basal state hyperinsulinemia in healthy normoglycemic adults heralds dysglycemia after more than two decades of follow up
Authors: Dankner R. , Chetrit A. , Shanik M.H. , Raz I. , Roth J. 
Published: August 2012

AbstractBackgroundIn a preliminary report, we found an association between hyperinsulinemia in the basal (fasting) state and the development of diabetes.ObjectivesThe current analysis further explored the long term link between basal hyperinsulinemia and conversion to dysglycemia.MethodsThis is a prospective study with up to 24 years of follow‐up of 515 normoglycemic individuals (mean age at follow up = 70.3 ± 7.0; range 58–94) of an Israeli cohort. Fasting glucose and insulin were measured, and dysglycemia was defined as fasting glucose > 100 mg/dL.ResultsAt the end of the follow‐up period, almost half had progressed to dysglycemia. Male sex and elevated baseline levels of basal insulin, body mass index, blood glucose and blood pressure each favoured progression to dysglycemia over the subsequent two decades. A multivariate logistic regression model identified basal hyperinsulinemia as the strongest predictor for progression to dysglycemia (odds ratio = 1.79; 95% confidence interval 1.12–2.88), while controlling for ethnicity, blood pressure, fasting glucose, male sex, body mass index and age.ConclusionsBasal hyperinsulinemia in normoglycemic adults constitutes an independent risk factor for metabolic deterioration to dysglycemia over adulthood, and may help to identify apparently healthy subjects at increased risk for diabetes. Copyright © 2012 John Wiley & Sons, Ltd.