bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantification of Efavirenz Hydroxymetabolites in Human Plasma Using LC-HRMS/MS
Authors: Pettersson Bergstrand Madeleine , Soeria-Atmadja Sandra , Barclay Victoria , Tolic Jelena , Navér Lars , Gustafsson Lars L. , Pohanka Anton 
Published: June 2024

Background:
Efavirenz (EFV) is a drug used to treat HIV. Low plasma concentrations of EFV result in suboptimal viral suppression, whereas high concentrations can cause adverse neuropsychiatric side reactions. Some studies have identified a correlation between the plasma concentrations of EFV metabolites and neurotoxicity. To our knowledge, no studies have investigated the metabolism of EFV in young children and its effect on treatment outcomes. Therefore, the aim of this study was to develop and validate a method for quantifying EFV and its metabolites in human plasma derived from children.

Methods:
Sample preparation was performed using protein precipitation of 100 µL plasma. Thereafter, an aliquot of the supernatant was used to quantify EFV, 7-hydroxyefavirenz (7-OH-EFV), 8-hydroxyefavirenz (8-OH-EFV), and a newly discovered metabolite (“EFAdeg”) associated with 8-OH-EFV. A second aliquot of the supernatant was hydrolyzed using β-glucuronidase/arylsulfatase and used with the first aliquot to quantify phase II metabolites. The analyses were performed using a Dionex Ultimate 3000RS LC-system coupled with a Q Exactive Orbitrap mass spectrometer.

Results:
The method has a measuring range of 100–50,000 ng/mL (EFV, 8-OH-EFV), 125–25,000 ng/mL (7-OH-EFV), and 200–10,000 ng/mL (“EFAdeg”). All criteria of the European Medicines Agency guidelines regarding precision, accuracy, and selectivity were met. Of note, carryover must be considered for 8-OH-EFV. Overall, the validated method was successfully applied to plasma samples obtained from children and confirmed the presence of the newly discovered metabolite, “EFAdeg.”

Conclusions:
An LC-HRMS/MS method for the quantification of EFV and its phase I and II metabolites was developed and validated. This method is suitable for analyzing plasma samples from children. Furthermore, studies using this method identified an additional metabolite that may influence the concentration of 8-OH-EFV in patient samples.
Long-Term Effectiveness of Vestibulectomy for the Treatment of Vulvodynia: A Retrospective Cohort Study
Authors: Coryn Nele , Vergauwe Bart , Weyers Steven , Verstraelen Hans 
Published: June 2024

Objective
To evaluate the effectiveness and complication rate of vestibulectomy for vulvodynia.

Methods
A retrospective cohort study in a teaching and university hospital analyzing patients with vulvodynia with insufficient response to conservative treatment who underwent a vestibulectomy. Data from 114 consecutive vestibulectomy procedures done between September 2009 and October 2018 were retrospectively analyzed. All procedures were performed by the same surgeon.
The primary outcome was difference in pain scale (6-point Q-tip test, Nociceptive Rating Scale) between preoperative consultation, postoperative visit, and last follow-up consultation. The secondary outcome was surgical complications, such as wound dehiscence and hematoma.

Results
Complete data were available for 80 patients. There was a significant reduction in median pain scores of between 65% and 80% on all 6 evaluated vestibular points during Q-tip tests. The median follow-up was 21 months, ranging from 1 to 92 months (interquartile range [IQR]). Overall, 75% of patients needed no further treatment at the end of the follow-up period. In 22.6% (18/80), a limited wound dehiscence was noted. No other complications were reported nor were there any cases of worsening of the complaints.

Conclusion/Discussion
In this retrospective cohort study, a significant pain reduction occurred after vestibulectomy in patients who were not responding to conservative treatment. The complication rate of this surgical procedure is low. Vestibulectomy seems to be an effective technique for management of vulvodynia.
Prevalence of Hypertensive Disorders of Pregnancy and Gestational Diabetes Mellitus by Race and Ethnicity in Illinois, 2018 to 2020
Authors: Reed Tiffany , Patil Crystal , Kershaw Kiarri N. , Crooks Natasha , Jeremiah Rohan , Park Chang 
Published: June 2024

Abstract

Purpose:
Use administrative discharge data from 2018 to 2020 to determine if there are differences in the prevalence of hypertensive disorders of pregnancy (HDP) and gestational diabetes mellitus (GDM) by race and ethnicity in Illinois.

Study Design and Methods:
This retrospective cross-sectional study used administrative discharge records from all patients who had live births in Illinois over a 3-year period; 2018, 2019, 2020. Multivariate analyses were performed to control for covariates and determine if associations vary by race and ethnicity for HDP and GDM.

Results:
A total of 287,250 discharge records were included. Multivariate analyses showed that after adjusting for covariates, non-Hispanic Black women had 1.60 increased odds of HDP compared to non-Hispanic White women (OR, 1.60; 95% CI, 1.55-1.65). Hispanic women (OR, 1.45; 95% CI, 1.40-1.50), Asian/Pacific Islander women (OR, 2.07; 95% CI, 1.97-2.17), and American Indian/Alaska Native women (OR, 1.43; 95% CI, 1.17-1.74) had an increased odds of GDM compared to non-Hispanic White women.

Clinical Implications:
Women of color were at increased odds for HDP and GDM in Illinois. To eliminate poor maternal outcomes in women of color at risk for HDP and GDM, more culturally congruent health equity practices, policies, and comprehensive care interventions must be adopted.
Expanding Integrated Physiatric Care
Authors: Fortin Christian D. , Robinson Lawrence R. 
Published: June 2024

Abstract
Siloed and episodic care delivery is often not equitable, high quality, or sustainable. Transitioning from separate care settings, with potentially divergent care models, to an integrated care model is not always straightforward. Some experiences in expanding collaborative care between physiatrists and other healthcare providers for a variety of patient populations and care settings within a university physical medicine and rehabilitation division are shared as a means to inspire the uptake of care integration initiatives more broadly within the specialty. After an initial survey of care integration across multiple clinical sites, the university division highlighted successful integrated care models, discussed integrated care models at every divisional retreat, reached out to clinicians in other specialties to collaboratively explore expansion, developed a “one-pager” on what physiatrists do, and invited collaborative specialists from integrated clinics to physical medicine and rehabilitation national and/or international meetings. Since 2019, divisional activity in integrated care has grown and evolved substantially. Future work will focus on further expansion of integrated clinical care, scholarly evaluation of integrated care models, expansion of academic activity resulting from integration, and advocacy to healthcare providers, hospital administrators, and health system funders about the potential value of care integration in improving rehabilitation outcomes.
INTERVENTIONS TO IMPROVE PATIENT SAFETY DURING THE COVID-19 PANDEMIC: A SYSTEMATIC REVIEW
Authors: Wu AW , Trigg K , Zhang A , Alexander GC , Haut ER , Rock C , McDonald KM , Padula WV , Fisseha S , Duncan R , Black J , Newman-Toker DE , Papieva I , Dhingra N , Wilson R 
Published: June 2024

AbstractObjectiveTo summarize the literature on health care interventions to reduce harm to patients caused by the COVID-19 pandemic across six domains: medication errors, diagnostic errors, surgical errors, health care-associated infections, pressure injuries, and falls.MethodsWe performed a mixed methods systematic review, with the intention to present results narratively. We combined parallel searches and experiential evidence across each domain of interest. We included studies published between 11 March 2020 and 28 August 2023 that reported an intervention in response to an identified patient safety issue. We identified 13,019 unique articles across the six domains. Of these, 590 full texts were assessed for eligibility. Seven were included for the medication safety domain; seven for diagnostic safety; 32 for surgical safety; 11 for health care-associated infections; six for the pressure injuries; and two for falls (Annex C). Overall, a total of 61 unique articles were included – four articles were represented across more than one domain.FindingsThere were few rigorous evaluations of specific interventions to reduce patient harm caused by the pandemic. Adjustments in treatments, triage, and procedures, and use of risk stratification tools reduced delays and permitted more elective surgery and diagnostic testing to proceed, improvements in medication safety practices, and prevention of health care-associated infections. Publications emphasized the importance of implementing existing practices and following the latest guidelines to prevent health care-associated infections, medication errors, pressure injuries and falls.ConclusionThere is little research on interventions to reduce patient harm caused in health care settings during the COVID-19 pandemic. Interventions focused on preventing nosocomial transmission of COVID-19, and on permitting access to urgent surgical and diagnostic needs. A few studies tested strategies to reduce new risks imposed by the pandemic for medication errors, health care-associated infections, pressure injuries, and falls. They also urged extra efforts to implement existing practices and following the latest guidelines already known to be effective. Development of high-reliability health systems and health care organizations to protect patients and health workers from harm, will be essential to mitigating the impact of future pandemics within the objectives of the Global Patient Safety Action Plan 2021-2030.
Home-based transcranial direct current stimulation (tDCS) in major depressive disorder: enhanced network synchronization with active relative to sham and deep learning-based predictors of remission
Authors: Xiao Wenyi , Moncy Jijomon C. , Woodham Rachel D. , Selvaraj Sudhakar , Lajmi Nahed , Hobday Harriet , Sheehan Gabrielle , Ghazi-Noori Ali-Reza , Lagerberg Peter J. , Machado-Vieira Rodrigo , Soares Jair C. , Young Allan H. , Fu Cynthia H.Y. 
Published: June 2024

AbstractAimTo investigate neural oscillatory networks in major depressive disorder (MDD), effects of home-based transcranial direct current stimulation (tDCS) treatment, and potential predictors of treatment remission.MethodsIn a randomised controlled trial (RCT) of home-based tDCS treatment, EEG data were acquired a subset: 21 MDD participants (16 women) (mean age 36.63 ± 9.71 years) in current depressive episode of moderate to severe severity (mean Hamilton Depression Rating Scale (HAMD) score 18.42 ± 1.80). Participants were randomised to either active (n=11) or sham tDCS (n=8). Treatment was home-based tDCS treatment for 10 weeks in a bifrontal montage (anode over left dorsolateral prefrontal cortex) consisting of 5 sessions per week for 3 weeks and 3 sessions per week for 7 weeks. Active tDCS was 2mA and sham tDCS 0mA with brief ramp up and ramp down period to mimic active stimulation. Each session was 30 minutes. Clinical remission was defined as HAMD score ≤ 7. Resting-state EEG data were acquired at baseline, prior to the start of treatment, and at 10-week end of treatment. EEG data were acquired using portable 4-channel EEG device (electrode positions: AF7, AF8, TP9, TP10). EEG band power was extracted for each electrode and functional connectivity phase synchronization by phase locking value (PLV). Deep learning was applied to baseline PLV features to identify predictors of treatment remission.ResultsMain effect of group was observed in gamma PLV in frontal and temporal regions, in which active tDCS treatment group showed higher connectivity as compared to sham group. In active treatment group, significant positive correlations between changes in delta, theta, alpha, and beta PLV and improvement in depression severity were observed. The highest treatment remission prediction was achieved by combining PLV features from theta, alpha, and beta: accuracy 71.94% (sensitivity 52.88%, specificity 83.06%).ConclusionsSynchronized brain activity across large-scale networks as reflected in gamma PLV is a potential mechanism of active tDCS as compared to placebo-sham tDCS. Baseline resting-state EEG is a potential predictor of treatment remission. Home-based EEG measures are feasible and potentially useful predictors of clinical outcome.
M2e-Derived Peptidyl and Peptide Amphiphile Micelles as Novel Influenza Vaccines
Authors: Schulte Megan C. , Barcellona Agustin T. , Wang Xiaofei , Ulery Bret D. 
Published: June 2024

AbstractA significant problem with current influenza vaccines is their reliance on predictions of what will be the most prevalent strains for the upcoming season. Mismatches between predictions and reality in any given year can greatly reduce the overall efficacy of an immunization campaign. A universal influenza vaccine, which leverages epitopes conserved across many, if not all, strains of influenza, can reduce the need for such accurate forecasting. The ectodomain of the M2 ion channel protein is highly conserved and includes a B cell epitope in the M22-16region, making it a potentially viable candidate as a universal influenza vaccine. Unfortunately, the use of free peptide antigens as vaccines comes with several disadvantages including poor stability and weak immunogenicityin vivo. However, integrating peptide antigens into nanoparticles can avoid some of those drawbacks. Previous studies have shown that micellar nanoparticles can be generated from peptides by conjugating them with a lipid or lipids. Specifically, hydrophobically-driven, self-assembled peptide amphiphile micelles comprised of Palm2K-peptide-(KE)4have been found to be immunostimulatory. Unlike other peptides previously used for this purpose, the M22-16peptide interestingly formed micelles without any peptidyl or lipid modifications. Because this unmodified peptide self-assembled on its own, it enabled the decoupling of the effect of micellization on immunogenicity from the incorporation of non-vaccine components such as the addition of a lipid moiety (Palm2K) and a zwitterion-like peptide block ((KE)4). The enclosed work shows that M22-16peptidyl micelles had some characteristic differences in shape, critical micelle concentration, and secondary structure when compared to M22-16peptide amphiphile micelles, which produced a few differences in murine antibody responses. These results suggest that peptide amphiphile micelles could be leveraged as a one-dose vaccine, while either micelle formulation induced strong immunological responses with a prime-booster immunization regimen.
Influence of movie-related online consumer reviews on movie choice: are there generational differences in processing information cues?
Authors: Alić Adi , Činjarević Merima 
Published: June 2024

PurposeTo understand how three features of online consumer reviews - the strength of persuasiveness in online consumer reviews (argument quality), the number of online consumer reviews (volume of reviews), and source credibility – are related to the behavioural intentions in the movie consumption context. Besides, the present study aims to explore intergenerational differences (X, Y, and Z) in the patterns of association between three characteristics of online consumer reviews (argument quality, volume of reviews, and source credibility) and an individual’s choice of a movie intended to be watched.Design/methodology/approachThe study sample (n = 518) was recruited from a population of users of IMDb living in Bosnia and Herzegovina. Structural equation modelling and multi-group analysis were used to test the proposed hypotheses.FindingsThe results revealed that argument quality, the volume of reviews, and source credibility of movie-related online consumer reviews are positively related to the intention to watch a movie for all three generational cohorts (X, Y, and Z). Regarding biases in processing information cues, our findings indicate that movie viewers from all three generations (X, Y, and Z) make inferences between source credibility and argument quality. However, biases in the relation between the volume of reviews and the argument quality were found only among X-ers and Y-ers but not among Z-ers.Originality/valueThe present study contributes to the eWOM research stream by examining the role of different characteristics of online consumer reviews (argument quality, the volume of reviews, and the source credibility) in movie consumption. Moreover, it sheds light on how argument quality, the volume reviews and the source credibility interact with the behavioural intentions of different generations and whether these interactions exhibit similarities or differences across three distinct generation cohorts: X-ers, Y-ers, and Z-ers.
A comparative study of minority entrepreneurship: entrepreneurial intention between LGBT versus traditional markets
Authors: Cavalcanti André L. , Ferreira João J. M. , Mota Veiga Pedro , Dabic Marina , Meyer Natanya 
Published: June 2024

PurposeThis study aims to analyze the entrepreneurial intention (EI) manifested by potential entrepreneurs for LGBT (lesbian, gay, bisexual, and transgender) and traditional markets, thereby tracing a comparative EI for both markets. The intention is to understand the vision of potential future entrepreneurs related to markets focused on the LGBT public (i.e. if entrepreneurs perceive this market as an option for future business).Design/methodology/approachUsing a quantitative research design, data were collected from a sample of 157 students in Brazil and analyzed by applying structural equation modeling.FindingsThis study primarily identified a difference between EI when comparing the focus on LGBT and traditional markets. Results show that the impact of personal attitude is significantly higher on EI for general markets (all markets) than for markets focused on LGBT audiences. Furthermore, the impact on entrepreneurship for traditional markets is generally significantly lower than for the LGBT market.Originality/valueThe study explored the EI for LGBT markets, which has not been studied extensively. It aims to gain a better understanding of various aspects that may influence the decision-making and perceptions of potential future entrepreneurs. Furthermore, the study compares traditional and LGBT audiences, providing valuable insights for potential future entrepreneurs in both scenarios. This comparison is a unique contribution to the literature and contributes to important analyses and debates.
How does enterprise social media use affect employees’ psychological well-being and innovative work performance? Findings from hybrid approaches
Authors: Bodhi Rahul 
Published: June 2024

PurposeRecent studies have suggested that the workplace fear of missing out (Workplace FoMO) harms employees' health and performance. Thus, the present study examines the impact of workplace FoMO and organisational support (OSP) on innovative work performance (IP) using dual theoretical lenses based on the conservation of resource theory (COR) and self-determination theory (SDT). Furthermore, this study investigates the mediating role of enterprise social media (ESM) use and psychological well-being (PW).Design/methodology/approachThe present study uses a rigorous methodology using structural equation modelling (SEM) and fuzzy-set qualitative comparative analysis (fsQCA). The author has conducted a cross-sectional survey to collect data on working professionals in India’s service industries (i.e. IT & ITeS; information technology enables services). Moreover, SEM was employed to analyse the data based on (n = 240) responses. Furthermore, fsQCA was used to reveal configurational models.FindingsThe SEM results revealed that workplace FoMO harms PW and stimulates ESM use. OSP has a positive impact on ESM use and PW. Furthermore, ESM use is positively associated with PW and enriches IP. The ESM use partially and significantly mediates (a) workplace FoMO and PW, and (b) OSP and PW. The fsQCA results revealed that two configurational models, (a) “ESM” and (b) “OSP*PW”, are vital in enhancing IP.Originality/valueThe present study utilises symmetric and asymmetric modelling approaches considering a separate prediction-oriented pioneer method. This study provides a novel perspective and adds new insights to the literature on ESM use, workplace FoMO and employee-related outcomes.
Peer observation in ELT at higher education: the implementation in synchronous online teaching
Authors: Sari Senorica Yulia , Fatimah Sitti 
Published: June 2024

PurposeOur paper examines how ELT lecturers perceive the feasibility of implementing Peer Observation (PO) in synchronous online settings, drawing on their prior experiences with offline PO. We also aim to identify potential areas for synchronous online PO.Design/methodology/approachWe employed semi-structured interviews with eight lecturers as participants. Data analysis included identifying keywords, transcribing and labeling responses, and sorting and categorizing the themes.FindingsFirstly, our findings indicate that lecturers reported several benefits from conducting offline PO, such as identifying teaching weaknesses, learning new techniques of teaching, gaining motivation, and receiving peer feedback. Participants also agreed that synchronous online PO is feasible and may offer greater benefits, especially with the shift to online teaching. Finally, the interview data highlighted potential areas for observation in synchronous online settings, including both pedagogical and technological aspects.Research limitations/implicationsFirstly, our study did not explore the potential and focus areas of synchronous online PO based on lecturers' actual experiences. Instead, we derived these potential and focuses from their experiences with offline PO. Secondly, the potential observation areas have not been validated.Practical implicationsThis study aims to contribute to the existing literature by exploring the potential of synchronous online PO and identifying key aspects for observation. Furthermore, in terms of practical implications, our findings may serve as a basis for developing validated guidelines for synchronous online PO, involving more practitioners. Additionally, lecturers and higher education institutions can consider implementing synchronous online PO to enhance teaching quality.Originality/valuePrevious literature has discussed ELT teachers' perceptions of offline PO, but limited research exists on its implementation in synchronous online contexts. Additionally, identifying potential areas for observation in synchronous online PO remains a concern.