bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI MINAT WISATAWAN BERKUNJUNG KE OBJEK WISATA BAHARI PULAU GILI LABAK KABUPATEN SUMENEP
Authors: Bulan Melkianus Teddison , Fawahid Ahmad 
Published: June 2024

This research aimed to analyze the factors that influenced tourists' interest in visiting the marine tourist attraction Gili Labak Island, Sumenep district. The type of research used in this research was quantitative. The population involved in this re­search was tourists who had visited the marine tourist attraction Gili Labak Island, Sumenep district, at least once, using purposive sampling, so the total sample required was 100 respondents. The data analysis used was multiple linear regression. The fin­dings showed that the promotion, tourist attrac­tion, and tourism motivation variables had a positive and significant effect on tourist’ interest in visiting, while the service quality variable had a negative and significant effect on tourists' interest in visiting the marine tourism area of Giri Labak Island, Sumenep district. The implications of this research provided direction for the management of marine tourism, object­­ed Gili Labak Isl­and, and Sumenep district, to continue to pay attention to service quality as an in­dica­tor that is given more attention than other factors so that service quality could inc­rease tourist interest in visiting. Penelitian ini bertujuan untuk menganalisis faktor-faktor yang memengaruhi mi­nat wisatawan berkunjung ke objek wisata bahari pulau Gili Labak kabupaten Su­me­nep. Jenis penelitian yang digunakan dalam penelitian ini adalah kuantitatif. Populasi yang dilibatkan dalam penelitian ini adalah para wisatawan yang pernah mengunjungi ke objek wisata bahari pulau Gili Labak kabupaten Sumenep minimal satu kali dengan pengambilan sampel purpo­sive sampling, sehingga total sampel yang dibutuhkan ada­lah 100 responden. Analisis data yang digunakan adalah regresi linear berganda. Hasil temuan menunjukkan bahwa variabel promosi, daya tarik wisata, dan motivasi wisata berpengaruh positif dan signifikan pada minat wisatawan berkunjung, sedangkan va­ri­abel kualitas pelayanan berpengaruh negatif dan signi­­­fikan pada ke wi­sa­ta minat wisatawan berkunjung bahari pulau Giri Labak kabupaten Sumenep. Implikasi pe­ne­li­ti­an ini mem­be­ri­kan arahan bagi manajemen objek wisata bahari pulau Gili Labak ka­bupaten Sumenep untuk terus memperhatikan kualitas pelayanan sebagai indikator yang lebih banyak diperhatikan dibandingkan dengan faktor lain, sehingga kualitas pelayanan dapat me­ningkatkan minat wisatawan berkunjung.
PENGARUH TENAGA KERJA DAN PENGELUARAN PEMERINTAH TERHADAP PRODUK DOMESTIK REGIONAL BRUTO SEKTOR PERTANIAN DI KAWASAN TIMUR INDONESIA
Authors: Himari Nadia Wahyuni , Suwandi Dai Sri Indriyani , Saleh Sri Endang , Santoso Ivan Rahmat 
Published: June 2024

Labor absorption and government expenditure were closely related to the agricul­tu­ral sector's gross regional domestic product (GRDP). This research aimed to analyze the influence of labor and government expenditure on GRDP in the agricultural sector in eastern Indonesia in 2017–2021. This research used a multiple linear regression analysis approach for panel data with a fixed effect model (FEM). The data used in this research were se­con­dary data obtained from Statistics Indonesia and the Directorate General of Financial Ba­lance (DJPK) of the Ministry of Finance of the Republic of Indonesia, obtained from 13 pro­vinces in Indonesia. The results of this research indicated that (1) labor in the agricultural sec­tor possessed a positive and insignificant effect on GRDP in the agricultural sector, mean­ing that every one percent increase in labor in the agricultural sector could increase GRDP in the agricultural sector in eastern Indonesia, but labor in the agricultural sector was not yet able to explain in real terms; (2) government spending in the agricultural sector possessed a positive and significant effect on the GDP of the agricultural sector, meaning that for every one Rupiah increase in government spending in the agricultural sector could increase the GDP value of the agricultural sector. This study provides practical implications for the go­vern­ment as a policymaker regarding labor and expenditure, especially in the agricultural sector. Penyerapan tenaga kerja dan pengeluaran pemerintah sangat erat kaitannya dengan Produk Domestik Regional Bruto (PDRB) sektor pertanian. Penelitian ini bertujuan untuk menganalisis pengaruh tenaga kerja dan pengeluaran pemerintah pada PDRB sektor per­tanian di Kawasan Timur Indonesia tahun 2017­–­2021. Penelitian ini menggu­na­kan pendekatan analisis regresi linear berganda data panel dengan fixed effect model (FEM). Data yang digunakan dalam penelitian ini adalah data sekunder yang ber­sum­ber dari Badan Pusat Sta­tistik dan Direktorat Jenderal Perimbangan Keuangan (DJPK) Kementerian Keuangan Repu­blik Indonesia yang diperoleh dari 13 provinsi di Indonesia. Hasil penelitian ini menunjukan bahwa (1) tenaga kerja sektor perta­ni­an berpengaruh positif dan tidak signifikan pada PDRB sektor pertanian, artinya se­tiap peningkatan satu persen tenaga kerja sektor pertanian, maka dapat mening­kat­kan PDRB sektor pertanian di Kawasan Timur Indonesia, akan tetapi tenaga kerja sek­tor pertanian belum mampu menjelaskan secara nyata; (2) pengeluaran peme­rin­tah di sektor pertanian berpengaruh positif dan signifikan pada PDRB sektor perta­ni­an, ar­ti­nya setiap peningkatan sebesar satu Rupiah pengeluaran pemerintah di sektor per­­ta­nian, maka dapat meningkatkan nilai PDRB sektor pertanian. Studi ini membe­rikan implikasi praktis bagi pemerintah selaku pengambil kebijakan terkait tenaga kerja dan pengeluaran khususnya di sektor pertanian.
Efektivitas Potongan Harga saat Festival Belanja Online 10.10 dan 11.11 di Toko Shopee @Bintang.lima_online
Authors: Wangnardy Winnie , Sutanto Eddy Madiono 
Published: June 2024

This study aimed to determine the effectiveness of discounted prices during the 10.10 and 11.11 online shopping festivals at the Bintang Lima online store. This qualitative research method involved semi-structured interviews with three informants, namely the owner, super­vi­sor, and customer of Toko Online Bintang Lima. The results showed that discounts effectively increased sales growth, consumer growth, and customer retention. The company is advised to consistently participate in online shopping festivals by providing discounts and other forms of promotion. Penelitian ini bertujuan untuk mengetahui efektivitas potongan harga saat festival be­lanja online 10.10 dan 11.11 di toko online Bintang Lima. Metode penelitian yang digunakan dalam penelitian ini adalah metode kualitatif yang melibatkan tiga orang informan, yaitu pemilik, supervisor, dan pelanggan Toko Online Bintang Lima dalam wawancara semi-ter­struk­tur. Teknik analisis data menggunakan analisis data Miles dan Huberman. Hasil penelitian ini menunjukkan bahwa potongan harga memiliki efektivitas dalam meningkatkan pertum­buh­an penjualan dan pertumbuhan konsumen, serta meningkatkan retensi pelanggan. Perusahaan disarankan untuk konsisten berpartisipasi dalam festival belanja online dengan memberikan potongan harga dan bentuk promosi lainnya.
Genetics of Neonatal Lupus Erythematosus Risk and Specific Manifestations
Authors: Misztal Melissa C. , Gold Nick , Cao Jingjing , Diaz Talia , Dominguez Daniela , Thompson Kendal , Jaeggi Edgar , Knight Andrea M. , Laskin Carl , Ng Lawrence , Silverman Earl D. , Hiraki Linda T. 
Published: June 2024

ObjectiveNeonatal lupus erythematosus (NLE) is a passively acquired autoimmune disease in infants born to anti-Ro and/or anti-La autoantibody-positive mothers. Genetics may affect NLE risk. We analyzed the genetics of infants and anti-Ro antibody-positive mothers, with NLE and NLE-specific manifestations.MethodsInfants and mothers from a tertiary care clinic underwent genotyping on the Global Screening Array. We created additive non-HLA and HLA polygenic risk scores (PRS) for systemic lupus erythematosus (SLE), from one of the largest genome-wide association studies. Outcomes were any NLE manifestations, cardiac NLE, and cutaneous NLE. We tested the association between SLE-PRS in the infant, mother, and the PRS difference between the mother and infant with NLE outcomes, in logistic regression and generalized linear mixed models (BonferroniP< 0.02). We also performed HLA-wide analyses for the outcomes (P< 5.00 × 10–8).ResultsThe study included 332 infants, 270 anti-Ro antibody-positive mothers, and 253 mother-infant pairs. A large proportion of mothers (40.4%) and infants (41.3%) were European, and 50% of infants were female. More than half of the infants had NLE (53%), including 7.2% with cardiac NLE and 11.7% with cutaneous NLE. We did not identify significant associations between infant PRS, maternal PRS, or maternal-infant PRS difference and any NLE outcomes. HLA-wide analyses did not identify NLE risk alleles.ConclusionIn a multiethnic cohort of infants and anti-Ro antibody-positive mothers, we did not identify a significant association between SLE genetics and risk of NLE outcomes.
Exploring Reproductive Experiences With Women Enrolled in the International Vasculitis Pregnancy Registry
Authors: Sims Catherine A. , Perry Brian , Yeung Christine , Tam Heather , Kullman Joyce , Borchin Renée L. , Burroughs Cristina , Merkel Peter A. , Clowse Megan E.B. 
Published: June 2024

ObjectiveThis study explored the reproductive journeys of women with vasculitis, including their conversations with healthcare providers, disease activity, medication changes, and delivery experiences.MethodsInterviews were conducted with women registered in the Vasculitis Pregnancy Registry (VPREG), an online patient-reported registry of pregnant women with vasculitis. A team of physicians, patients, and qualitative researchers developed a qualitative interview guide. Participant responses were evaluated using thematic analysis.ResultsEighteen patients with vasculitis who had experienced pregnancy were interviewed (10 antineutrophil cytoplasmic antibody–associated vasculitis, 4 Takayasu arteritis, 2 Behçet disease, 1 IgA vasculitis, 1 relapsing polychondritis). Thematic analysis revealed common experiences in the decision-making process during pregnancy planning, including accessing information from multiple sources, communicating with medical professionals, and changing treatment for vasculitis. Women sought information about vasculitis and pregnancy from various sources, including social media; however, opinions from their physicians and family members were most influential. Patients were more likely than providers to initiate conversations regarding family planning. Balancing differing opinions from subspecialists was challenging as many patients recalled acting as a liaison between multiple physicians during pregnancy. The need for self-advocacy was a common experience among patients. Most women had pregnancies that resulted in live births with delivery at term.ConclusionWhen making decisions about pregnancy, women of reproductive age with vasculitis used multiple resources. Patients consistently valued their medical provider's opinion over alternative sources of information. To ensure comprehensive medical care, half of women relied on self-advocacy to coordinate communication among subspecialists. Most women had pregnancies that resulted in live births with delivery at term.
Telerheumatology Shared-Care Model: Leveraging the Expertise of an Advanced Clinician Practitioner in Arthritis Care (ACPAC)-Trained Extended Role Practitioner in Rural-Remote Ontario
Authors: Steiman Amanda , Inrig Taucha , Lundon Katie , Murdoch Jocelyne , Shupak Rachel 
Published: June 2024

ObjectiveA shortage of rheumatologists has led to gaps in inflammatory arthritis (IA) care in Canada. Amplified in rural-remote communities, the number of rheumatologists practicing rurally has not been meaningfully increased, and alternate care strategies must be adopted. In this retrospective chart review, we describe the impact of a shared-care telerheumatology model using a community-embedded Advanced Clinician Practitioner in Arthritis Care (ACPAC)–extended role practitioner (ERP) and an urban-based rheumatologist.MethodsA rheumatologist and an ACPAC-ERP established a monthly half-day hub-and-spoke-telerheumatology clinic to care for patients with suspected IA, triaged by the ACPAC-ERP. Comprehensive initial assessments were conducted in-person by the ACPAC-ERP (spoke); investigations were completed prior to the telerheumatology visit. Subsequent collaborative visits occurred with the rheumatologist (hub) attending virtually. Retrospective analysis of demographics, time-to–key care indices, patient-reported outcomes, clinical data, and estimated travel savings was performed.ResultsData from 124 patients seen between January 2013 and January 2022 were collected; 98% (n = 494/504 visits) were virtual. The average age of patients at first visit was 55.6 years, and 75.8% were female. IA/connective tissue disease (CTD) was confirmed in 65% of patients. Mean time from primary care referral to ACPAC-ERP assessment was 52.5 days, and mean time from ACPAC-ERP assessment to the telerheumatology visit was 64.5 days. An estimated 493,470 km of patient-related travel was avoided.ConclusionAn ACPAC-ERP (spoke) and rheumatologist (hub) telerheumatology model of care assessing and managing patients with suspected IA in rural-remote Ontario was described. This model can be leveraged to increase capacity by delivering comprehensive virtual rheumatologic care in underserved communities.
Efficacy and Safety of Tofacitinib in Ankylosing Spondylitis by Baseline C-Reactive Protein Level: Post Hoc Analysis of Phase II and Phase III Clinical Trials
Authors: Deodhar Atul , Baraliakos Xenofon , Magrey Marina , Gensler Lianne S. , Thorat Amit V. , Pemmaraju Surya Kiran , Cadatal Mary Jane , Nash Peter 
Published: June 2024

ObjectiveThis post hoc analysis assessed the effect of baseline C-reactive protein (CRP) on the efficacy and safety of tofacitinib (TOF) use in ankylosing spondylitis (AS), as well as patient-reported outcomes (PROs).MethodsPhase II (ClinicalTrials.gov:NCT01786668) and phase III (ClinicalTrials.gov:NCT03502616) data from patients with active AS were used. Endpoints (weeks 12, 16, and 48), including 20% and 40% improvement in Assessment of SpondyloArthritis international Society (ASAS), AS Disease Activity Score with CRP low disease activity, 50% improvement in Bath AS Disease Activity Index (BASDAI50), and PROs (pain and fatigue), were stratified by baseline CRP (mg/L) as follows: < 5 (normal), ≥ 5 (elevated), < 10, and ≥ 10. Safety outcomes were evaluated between < 5 and ≥ 5 mg/L subgroups.ResultsOverall, 372 patients were included (69.6% ≥ 5mg/L; 50.8% ≥ 10 mg/L). At baseline in the < 5mg/L group, more placebo-treated than TOF-treated patients received concomitant nonsteroidal antiinflammatory drugs (NSAIDs) or sulfasalazine (SSZ). Week 12 efficacy and PRO responses were generally higher for TOF vs placebo, regardless of baseline CRP. The treatment effect (placebo-adjusted response) at week 12 was generally numerically higher in ≥ 5 mg/L and ≥ 10 mg/L vs < 5 mg/L and < 10 mg/L groups. Incidence rates for treatment-emergent adverse events (TEAEs) and “all infections” were numerically higher for TOF vs placebo in patients in the < 5 mg/L group, but similar for TOF vs placebo in patients in the ≥ 5 mg/L group.ConclusionRegardless of baseline CRP, TOF was more efficacious vs placebo at week 12. The placebo-adjusted efficacy and PRO responses were generally numerically higher in patients with CRP ≥ 5 mg/L and ≥ 10 mg/L vs < 5 mg/L and < 10 mg/L. The higher concomitant NSAID/SSZ exposure may have improved efficacy responses in the baseline < 5 mg/L placebo group, and ultimately affected the TOF treatment effect. Safety was consistent with previous studies of TOF use in AS, with numerically higher incidence rates for TEAEs and “all infections” for TOF vs placebo in patients with CRP < 5 mg/L.
Effects of Radiotherapy for Malignancy in Systemic Sclerosis: A Systematic Review
Authors: Aboabat Aos , Aldohan Mohammed , Cheung Patrick , Orchanian-Cheff Ani , Johnson Sindhu R. 
Published: June 2024

ObjectiveConcerns regarding offering radiotherapy to patients with systemic sclerosis (SSc) stem from the potential worsening of SSc manifestations and radiotherapy toxicity. We conducted a systematic review to evaluate the effects of radiotherapy on SSc outcomes and radiotherapy-related toxicity.MethodsMEDLINE, Embase, Cochrane Database of Systematic Reviews, and Cochrane Central Register of Controlled Trials were searched for SSc and radiotherapy. Inclusion criteria were SSc diagnosis, subsequent cancer development, and radiotherapy exposure. Outcomes were SSc manifestations (cutaneous thickening, pulmonary fibrosis, and SSc flare) and radiotherapy toxicity (acute and late) using Common Terminology Criteria for Adverse Events for grading. Grade 1 and 2 toxicities were categorized as nonsevere and grade 3 to 5 toxicities as severe.ResultsOf 121 patients with SSc undergoing radiotherapy (mean age 56.4 years, 83.3% female, median radiotherapy dose 50 Gy), most did not show worsened SSc skin thickening (74.5%) or pulmonary complications (74%) post radiotherapy. In retrospective studies, the average rates of acute adverse effects were 57.3% for nonsevere and 25.8% for severe, whereas the rates of late adverse effects were 32.4% for nonsevere and 24% for severe.ConclusionAlthough most patients with SSc do not exhibit significant worsening of SSc manifestations post radiotherapy, there is a variable risk of acute and late toxicity. These findings suggest that although radiotherapy may be a viable option for patients with cancer with SSc, it requires caution.
Reproductive Outcomes for Women With Vasculitis
Authors: Sims Catherine A. , Eudy Amanda M. , Larson Kalen , Yeung Christine , Tam Heather , Kullman Joyce , Borchin Renée L. , Burroughs Cristina , Merkel Peter A. , Clowse Megan E.B. 
Published: June 2024

ObjectiveThere are limited data on the reproductive health of women with vasculitis. This study used a prospective, international vasculitis pregnancy registry to survey women during and after pregnancy.MethodsThe Vasculitis Pregnancy Registry (VPREG) is imbedded within the Vasculitis Patient-Powered Research Network, an international online research infrastructure. Any pregnant woman with a diagnosis of vasculitis can self-enroll. After enrollment, women are invited to complete online surveys at study entry, once per trimester, and postpartum. Descriptive statistics are reported here.ResultsBetween 2015 and 2022, 147 women with 149 pregnancies enrolled in VPREG from 16 countries. Data on 78 pregnancies with known outcomes were included in this analysis. During pregnancy, women on average experienced low levels of pain related to vasculitis (scale 0-10, median 2 [IQR 1-5]) and preserved feelings of wellness (scale 0-10, median 3 [IQR 1-5]). Thirty-six percent of women reported their vasculitis was active during pregnancy. Of the 14 women requiring hospitalization during pregnancy outside of delivery, 4 cited active vasculitis as the indication. Most women (54/73, 74%) were prescribed medications for vasculitis during pregnancy. Seventy-six (97%) pregnancies resulted in live births, with 64% delivering vaginally and 21% experiencing a preterm delivery.ConclusionThese results demonstrate that most women with vasculitis can experience pregnancies that result in live births delivered at term. During pregnancy, a minority of women reported flares of vasculitis or the need for hospitalization due to vasculitis. These data are useful to rheumatologists and patients to inform and facilitate discussions about reproductive health and vasculitis.
Implementation of a Clinician-led Medication Adherence Intervention Among Patients With Systemic Lupus Erythematosus
Authors: Sun Kai , Molokwu Nneka J. , Hanlen-Rosado Emily , Corneli Amy L. , Pollak Kathryn I. , Rogers Jennifer L. , Sadun Rebecca E. , Criscione-Schreiber Lisa G. , Doss Jayanth , Bosworth Hayden B. , Clowse Megan E.B. 
Published: June 2024

ObjectiveMedication nonadherence in systemic lupus erythematosus (SLE) leads to poor clinical outcomes. We developed a clinician-led adherence intervention that involves reviewing real-time pharmacy refill data and using effective communication to address nonadherence. Prior pilot testing showed promising effects on medication adherence. Here, we describe further evaluation of how clinicians implemented the intervention and identify areas for improvement.MethodsWe audio recorded encounters of clinicians with patients who were nonadherent (90-day proportion of days covered [PDC] < 80% for SLE medications). We coded recordings for intervention components performed, communication quality, and time spent discussing adherence. We also conducted semistructured interviews with patients and clinicians on their experiences and suggestions for improving the intervention. We assessed change in 90-day PDC post intervention.ResultsWe included 25 encounters with patients (median age 39, 100% female, 72% Black) delivered by 6 clinicians. Clinicians performed most intervention components consistently and exhibited excellent communication, as coded by objective coders. Adherence discussions took an average of 3.8 minutes, and 44% of patients had ≥ 20% increase in PDC post intervention. In structured interviews, many patients felt heard and valued and described being more honest about nonadherence and more motivated to take SLE medications. Patients emphasized patient-clinician communication and financial and logistical assistance as areas for improvement. Some clinicians wanted additional resources and training to improve adherence conversations.ConclusionWe provide further evidence to support the feasibility, acceptability, and fidelity of the adherence intervention. Future work will optimize clinician training and evaluate the intervention’s effectiveness in a large, randomized trial.
Evaluation of the Rheumatoid Arthritis Impact of Disease (RAID) Score in Assessing Rheumatoid Arthritis Activity in Teleconsultation
Authors: Avouac Jérôme , Molto Anna , Allanore Yannick 
Published: June 2024

ObjectiveTo evaluate the relevance of the Rheumatoid Arthritis Impact of Disease (RAID) score as a disease activity marker of rheumatoid arthritis (RA) in a teleconsultation setting.MethodsA prospective, observational, 24-month, single-center study involving patients with RA who underwent teleconsultations was performed. The RAID score was sent to all patients by email and completed the day before the scheduled session. The RAID questionnaire was also completed just prior to the next scheduled face-to-face consultation. The same physician performed teleconsultation/in-person consultations and was unaware of the RAID results.ResultsWe included 70 patients (mean age 50 [SD 14] yrs, mean disease duration 10 [SD 9] yrs). The RAID score correlated with the following items: patient global assessment (r0.55,P< 0.001), patient-reported swollen joint count (r0.50,P< 0.001), and Disease Activity Score in 28 joints based on C-reactive protein (DAS28-CRP) calculated with patient self-reported tender/swollen joints (r0.74,P< 0.001). The RAID score completed during the next face-to-face consultation for 45 patients also correlated with the DAS28-CRP performed by the clinician (r0.65,P< 0.001). A RAID score > 2 was associated with the best combination of sensitivity (94%) and specificity (43%) for the indication of rapid in-person consultation because of insufficiently controlled disease activity, with an area under the curve of 0.74. All 23 patients with RAID < 2 had no intercurrent flares; overall physician global assessment was 1.6 of 10 (SD 1.4), DAS28-CRP 1.5 (SD 0.2), and CRP 1.8 (SD 1.4) mg/L.ConclusionOur findings reinforce the RAID score as a valuable tool in teleconsultation, exhibiting a good correlation with disease activity variables. Using a RAID score threshold of 2 during teleconsultations could distinguish patients with good disease control and those with the potential need for an in-person visit.