bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnosis and treatment of bacterial peritonitis in patients with gastrointestinal cancer: an observational multicenter study
Authors: Riescher-Tuczkiewicz Alix , Grégory Jules , Bert Frederic , Zappa Magaly , Pellat Anna , Lalande Valerie , Gallois Claire , Mainardi Jean-Luc , Bachet Jean-Baptiste , Robert Jérôme , Bourrel Anne Sophie , Coriat Romain , Thabut Dominique , Hammel Pascal , Rebours Vinciane , Lorenzo Diane 
Published: June 2024

Background: Bacterial peritonitis (BP) in patients with gastrointestinal (GI) cancer has been poorly described, and its prevalence is unknown. Objectives: This study aimed to evaluate in patients with both GI cancer and ascites the prevalence of BP, associated features, mechanisms, prognosis, and the diagnostic performance of neutrophil count in ascites. Design: A retrospective, multicenter, observational study. Methods: All patients with GI cancer and ascites who underwent at least one paracentesis sample analyzed for bacteriology over a 1-year period were included. BP was defined by a positive ascites culture combined with clinical and/or biological signs compatible with infection. Secondary BP was defined as BP related to a direct intra-abdominal infectious source. Results: Five hundred fifty-seven ascites from 208 patients included were analyzed. Twenty-eight patients had at least one episode of BP and the annual prevalence rate of BP was 14%. Among the 28 patients with BP, 19 (65%) patients had proven secondary BP and 17 (59%) patients had multi-microbial BP, mainly due to Enterobacterales. A neutrophil count greater than 110/mm3 in ascites had negative and positive predictive values of 96% and 39%, respectively, for the diagnosis of BP. The median survival of patients with BP was 10 days (interquartile range 6–40) after the diagnosis. Conclusion: BP is not rare in patients with GI cancer and is associated with a poor short-term prognosis. When a patient with GI cancer is diagnosed with BP, a secondary cause should be sought. Further studies are needed to better define the best management of these patients.
Observing executive functioning of neurodivergent students and supporting practices of their teachers in the classroom
Authors: Safer-Lichtenstein Jonathan , Kenworthy Lauren , Verbalis Alyssa , Ba Caroline , Mikulich-Gilbertson Susan , Anthony Bruno J. , Anthony Laura G. 
Published: June 2024

Executive function (EF) challenges, including difficulties with cognitive flexibility, planning/ organization, and emotional control, are common in neurodivergent children. We developed the Behavioral Observation of Classroom Executive Functioning (BOCEF) tool to examine observable EF-related behaviors of elementary students and EF-supporting strategies of their teachers. The BOCEF student score correlated significantly with teacher-completed ratings of similar behaviors. Autistic students ( n = 48) and students with ADHD ( n = 98) were rated as having similar rates of several EF-related behaviors, while autistic students were rated as significantly more likely to get “stuck.” Teachers were found to be more likely to display strategies of planning, clear instructions, and visual supports, and less likely to utilize favorable praise to correction ratios, transition priming, flexibility, rule referencing, or behavioral reward systems. Praise was the teacher strategy found to have the greatest association with student behavior. Implications for student accommodation/support and teacher training are discussed. Lay abstract Autistic children and children with ADHD often have difficulties with thinking flexibility, planning, and managing frustration. We developed a tool called the Behavioral Observation of Classroom Executive Functioning (BOCEF) to evaluate how children struggle with these executive functioning behaviors in the classroom, and how often teachers are using strategies known to support these behaviors. Our ratings of students on the BOCEF were similar to how teachers rated these same types of behaviors in these students. Autistic students ( n = 48) and students with ADHD ( n = 98) were rated as having similar rates of difficulties in the classroom, with the exception that autistic students got “stuck” more often, meaning they had more difficulty moving on from specific ideas or topics. Teachers were found to be more likely to display strategies of planning, clear instructions, and visual supports, and less likely to utilize adequate praise, warnings prior to transitions, flexibility, rule referencing, or behavioral reward systems. Praise was the teacher strategy found to be most related to student behavior. Findings from this study indicate the BOCEF could be helpful for schools to determine how much these types of challenges are impacting neurodivergent students in the classroom. Additional teacher training on incorporating praise and other ways to support neurodivergent students in the classroom is also likely to be important moving forward.
Characteristics of exacerbators in the US Bronchiectasis and NTM Research Registry: a cross-sectional study
Authors: Lapinel Nicole C. , Choate Radmila , Aksamit Timothy R. , Feliciano Joseph , Winthrop Kevin L. , Schmid Andreas , Fucile Sebastian , Metersky Mark L. 
Published: June 2024

BackgroundExacerbations of noncystic fibrosis bronchiectasis (bronchiectasis) are associated with reduced health-related quality of life and increased mortality, likelihood of hospitalisation and lung function decline. This study investigated patient clinical characteristics associated with exacerbation frequency.MethodsA cross-sectional cohort study of patients ≥18 years with bronchiectasis enrolled in the US Bronchiectasis and Nontuberculous Mycobacteria (NTM) Research Registry (BRR) September 2008–March 2020. Patients were stratified by exacerbation frequency in their 2 years before enrolment. Patient demographics, respiratory symptoms, healthcare resource utilisation, microbiology, modified bronchiectasis severity index (mBSI) and select comorbidities were collected at enrolment. Patient characteristics associated with exacerbation frequency were assessed using a negative binomial model.ResultsThe study included 2950 patients (mean age 65.6 years; 79.1% female). Frequency of moderate to severe airway obstruction (forced expiratory volume in 1 s (FEV1) % predicted <50%; most recent measure) was 15.9%, 17.8%, and 24.6% in patients with 1, 2, and ≥3 exacerbationsversus8.9% in patients with 0 exacerbations; severe disease (mBSI) was 27.8%, 24.2% and 51.1%versus13.2%; respiratory hospitalisation was 24.5%, 33.0% and 36.5%versus4.1%; andPseudomonas aeruginosainfection was 18.8%, 23.4% and 35.2%versus11.9%. In multivariable model analysis, respiratory hospitalisation, cough, haemoptysis,P. aeruginosa, younger age, lower FEV1% predicted, asthma, and gastro-oesophageal reflux disease were associated with more exacerbations.ConclusionsThese findings demonstrate a high disease burden, including increased respiratory symptoms, healthcare resource utilisation, andP. aeruginosainfection in patients with bronchiectasis and multiple exacerbations.
Global, regional, and national burden and trends of migraine among women of childbearing age from 1990 to 2021: insights from the Global Burden of Disease Study 2021
Authors: Cen Jing , Wang Qian , Cheng Lin , Gao Qian , Wang Hongping , Sun Fengjun 
Published: June 2024

Abstract
Background
Migraine, a neurological disorder with a significant female predilection, is the leading cause of disability-adjusted life years (DALYs) in women of childbearing age (WCBA). There is currently a lack of comprehensive literature analysis on the overall global burden and changing trends of migraines in WCBA.

Methods
This study extracted three main indicators, including prevalence, incidence, and DALYs, related to migraine in WCBA from the Global Burden of Disease(GBD) database from 1990 to 2021. Our study presented point estimates with 95% uncertainty intervals (UIs). It evaluated the changing trends in the burden of migraine in WCBA using the estimated annual percentage change (EAPC) and percentage change.

Results
In 2021, the global prevalence, incidence, and DALYs cases of migraine among WCBA were 493.94 million, 33.33 million, and 18.25 million, respectively, with percentage changes of 48%, 43%, and 47% compared to 1990. Over the past 32 years, global prevalence rates and DALYs rates globally have increased, with an EAPC of 0.03 (95% UI: 0.02 to 0.05) and 0.04 (95% UI: 0.03 to 0.05), while incidence rates have decreased with an EAPC of -0.07 (95% UI: -0.08 to -0.05). Among the 5 Socio-Demographic Index (SDI) regions, in 2021, the middle SDI region recorded the highest cases of prevalence, incidence, and DALYs of migraine among WCBA, estimated at 157.1 million, 10.56 million, and 5.81 million, respectively, approximately one-third of the global total. In terms of age, in 2021, the global incidence cases for the age group 15–19 years were 5942.5 thousand, with an incidence rate per 100,000 population of 1957.02, the highest among all age groups. The total number of migraine cases and incidence rate among WCBA show an increasing trend with age, particularly in the 45–49 age group.

Conclusions
Overall, the burden of migraine among WCBA has significantly increased globally over the past 32 years, particularly within the middle SDI and the 45–49 age group. Research findings emphasize the importance of customized interventions aimed at addressing the issue of migraines in WCBA, thus contributing to the attainment of Sustainable Development Goal 3 set by the World Health Organization.
Highly conductive and durable nanocomposite hard coatings of carbon fiber reinforced thermoplastic composites against lightning strikes
Authors: Parten Clay , Subeshan Balakrishnan , Asmatulu Ramazan 
Published: June 2024

AbstractThe growing use of thermoplastic composites (TPCs) like low-melting polyaryletherketone (LM-PAEK) matrices reinforced with unidirectional carbon fiber (CF) in aircraft structures presents a significant challenge in terms of lightning strikes and electromagnetic interference shielding during aircraft operations. This is due to the weak electrical conductivity of TPC structures, which results in widespread damage when struck by lightning. The repair and maintenance of these extended damaged sites can increase operational costs and loss of flights. Several lightning strike protection (LSP) systems have been developed and implemented to address these concerns. This study evaluated a highly conductive coating with a low filler rate for its effectiveness as an LSP solution for TPCs on exterior aircraft surfaces. The TPC panel without any coatings was first studied. Subsequently, the level of conductivity was increased by incorporating the nanoscale conductive fillers, silver-coated copper (Ag/Cu) nanoflakes, with a silver content of 20 wt.% (Ag20/Cu) and 30 wt.% (Ag30/Cu), correspondingly, into the coating at two loadings of 55 wt.% and 70 wt.% in an epoxy carrier for the surface coatings. The behavior of electrical and surface conductivity was thoroughly examined to understand the impact of Ag/Cu with a high aspect ratio and the effectiveness of the LSP solution. In addition, the spray-coated TPC panels underwent rigorous Zone 2A lightning strike testing using simulated lightning current, in agreement with the industry standard of Society of Automotive Engineers (SAE) Aerospace Recommended Practice (ARP) 5412B. Despite the higher resistance due to the lower conductive coating weight, the TPC panels with Ag30/Cu at loading of 70 wt.% achieved better results than those with Ag30/Cu at loading of 55 wt.%. This is evidenced by the minor structural delamination and CF breakage on the front surface, which proposes a new economic route for a sustainable post-processed LSP system in the aviation industry.
dgfr: an R package to assess sequence diversity of gene families
Authors: Almeida Laila Viana , Reis-Cunha João Luís , Bartholomeu Daniella C. 
Published: June 2024

Abstract
Background
Gene families are groups of homologous genes that often have similar biological functions. These families are formed by gene duplication events throughout evolution, resulting in multiple copies of an ancestral gene. Over time, these copies can acquire mutations and structural variations, resulting in members that may vary in size, motif ordering and sequence. Multigene families have been described in a broad range of organisms, from single-celled bacteria to complex multicellular organisms, and have been linked to an array of phenomena, such as host–pathogen interactions, immune evasion and embryonic development. Despite the importance of gene families, few approaches have been developed for estimating and graphically visualizing their diversity patterns and expression profiles in genome-wide studies.

Results
Here, we introduce an R package named dgfr, which estimates and enables the visualization of sequence divergence within gene families, as well as the visualization of secondary data such as gene expression. The package takes as input a multi-fasta file containing the coding sequences (CDS) or amino acid sequences from a multigene family, performs a pairwise alignment among all sequences, and estimates their distance, which is subjected to dimension reduction, optimal cluster determination, and gene assignment to each cluster. The result is a dataset that allows for the visualization of sequence divergence and expression within the gene family, an approximation of the number of clusters present in the family.

Conclusions
dgfr provides a way to estimate and study the diversity of gene families, as well as visualize the dispersion and secondary profile of the sequences. The dgfr package is available at https://github.com/lailaviana/dgfr under the GPL-3 license.
The influence of climate change on the sesame yield in North Gondar, North Ethiopia: Application Autoregressive Distributed Lag (ARDL) time series model
Authors: Abebe Dagnew Melake , Mengistie Dagne Tesfaye , Mekonen Aychew Alemie 
Published: June 2024

AbstractSesame is a major annual oil crop that is grown practically everywhere in tropical and subtropical Asia, as well as Africa, for its very nutritious and tasty seeds. Rising temperatures, droughts, floods, desertification, and weather all have a significant impact on agricultural production, particularly in developing countries like Ethiopia. Therefore, the main objective of this study is to examine the influence of climate change on the sesame yield in North Gondar, North Ethiopia, by using the autoregressive distributed Lag (ARDL) time series model. This study employed climate data from the Bahirdar Agrometeorological Center and secondary data on sesame production from the Ethiopian Statistical Service, spanning 36 years, from 1987 to 2023. Autoregressive Distributed LAG (ARDL) includes diagnostic tests for both short- and long-term autoregressive models. The results for the long-run and short-run elastic coefficients show a significant positive association between temperatures and sesame yield. Sesame yield and rainfall have a significant negative long-run and short-run relationship in North Gondar, North Ethiopia. ARDL results confirm that temperature and rainfall have significant effects on sesame productivity. Temperature had a considerable favorable effect on sesamen production, but rainfall had a negative effect in North Gondar, Ethiopia. Based on the evidence acquired from our study, we made several policy recommendations and suggestions to government officials, policymakers, new technologies, researchers, policy development planners, and other stakeholders in order to develop or implement new technology to halt its production and direct adaptation measures in light of the certainty of global warming and the characteristics of climate-dependent agricultural production.
Left atrial appendage closure in a patient previously implanted with an interatrial shunt device: a case report
Authors: Lin Dawei , Li Mingfei , Weng Zilong , Pan Wenzhi , Zhou Daxin , Ge Junbo 
Published: June 2024

AbstractPatients with previous interatrial shunt device (IASD) implantation may face greater challenges during future left atrial interventional procedures. Herein, we report the first case of left atrial appendage closure (LAAC) in a patient with previous IASD implantation. The patient successfully underwent LAAC using the LAmbre device without complications.
Determinants of sedentary behavior in community-dwelling older adults with type 2 diabetes based on the behavioral change wheel: a path analysis
Authors: Zhang Xiaoyan , Yang Dan , Luo Jiayin , Meng Meiqi , Chen Sihan , Li Xuejing , Yin Yiyi , Hao Yufang , Sun Chao 
Published: June 2024

Abstract
Background
Sedentary behavior (SB) is deeply ingrained in the daily lives of community-dwelling older adults with type 2 diabetes mellitus (T2DM). However, the specific underlying mechanisms of the determinants associated with SB remain elusive. We aimed to explore the determinants of SB based on the behavior change wheel framework as well as a literature review.

Methods
This cross-sectional study recruited 489 community-dwelling older adults with T2DM in Jinan City, Shandong Province, China. Convenience sampling was used to select participants from relevant communities. This study used the Measure of Older Adults’ Sedentary Time-T2DM, the Abbreviated-Neighborhood Environment Walkability Scale, the Social Support Rating Scale, the Lubben Social Network Scale 6, the Subjective Social Norms Questionnaire for Sedentary Behavior, the Functional Activities Questionnaire, the Numerical Rating Scale, the Short Physical Performance Battery, and the Montreal Cognitive Assessment Text to assess the levels of and the determinants of SB. Descriptive statistical analysis and path analysis were conducted to analyze and interpret the data.

Results
Pain, cognitive function, social isolation, and social support had direct and indirect effects on SB in community-dwelling older adults with T2DM (total effects: β = 0.426, β = -0.171, β = -0.209, and β = -0.128, respectively), and physical function, walking environment, and social function had direct effects on patients’ SB (total effects: β = -0.180, β = -0.163, and β = 0.127, respectively). All the above pathways were statistically significant (P < 0.05). The path analysis showed that the model had acceptable fit indices: RMSEA = 0.014, χ 2/df = 1.100, GFI = 0.999, AGFI = 0.980, NFI = 0.997, RFI = 0.954, IFI = 1.000, TLI = 0.996, CFI = 1.000.

Conclusion
Capability (physical function, pain, and cognitive function), opportunity (social isolation, walking environment, and social support), and motivation (social function) were effective predictors of SB in community-dwelling older adults with T2DM. Deeper knowledge regarding these associations may help healthcare providers design targeted intervention strategies to decrease levels of SB in this specific population.
Short-term culture for rapid identification by mass spectrometry and automated antimicrobial susceptibility testing from positive bottles
Authors: Tian Peng-Peng , Su Shan-Shan , Zhu Li-Sha , Wang Tian , Yang Hui , Du Meng-Yao , Ding Cai-Zhi , Wang Li , Fan Wen , Yi Hua-Wei 
Published: June 2024

Abstract
Background
Early and appropriate antibiotic treatment improves the clinical outcome of patients with sepsis. There is an urgent need for rapid identification (ID) and antimicrobial susceptibility testing (AST) of bacteria that cause bloodstream infection (BSI). Rapid ID and AST can be achieved by short-term incubation on solid medium of positive blood cultures using MALDI-TOF mass spectrometry (MS) and the BD M50 system. The purpose of this study is to evaluate the performance of rapid method compared to traditional method.

Methods
A total of 124 mono-microbial samples were collected. Positive blood culture samples were short-term incubated on blood agar plates and chocolate agar plates for 5 ∼ 7 h, and the rapid ID and AST were achieved through Zybio EXS2000 MS and BD M50 System, respectively.

Results
Compared with the traditional 24 h culture for ID, this rapid method can shorten the cultivation time to 5 ∼ 7 h. Accurate organism ID was achieved in 90.6% of Gram-positive bacteria (GP), 98.5% of Gram-negative bacteria (GN), and 100% of fungi. The AST resulted in the 98.5% essential agreement (EA) and 97.1% category agreements (CA) in NMIC-413, 99.4% EA and 98.9% CA in PMIC-92, 100% both EA and CA in SMIC-2. Besides, this method can be used for 67.2% (264/393) of culture bottles during routine work. The mean turn-around time (TAT) for obtaining final results by conventional method is approximately 72.6 ± 10.5 h, which is nearly 24 h longer than the rapid method.

Conclusions
The newly described method is expected to provide faster and reliable ID and AST results, making it an important tool for rapid management of blood cultures (BCs). In addition, this rapid method can be used to process most positive blood cultures, enabling patients to receive rapid and effective treatment.
Tuberculous ciliary body granuloma initially diagnosed as bullous retinal detachment: a case report
Authors: Zhu Jie , Xu Huirong , Chang Qing , Chen Fang 
Published: June 2024

Abstract
Background
Ocular tuberculosis is a relatively rare extrapulmonary manifestation of tuberculosis. This vision-threatening disease is extremely challenging to diagnose, particularly because it can mimic other diseases. We report a case of tuberculous ciliary body granuloma initially diagnosed as bullous retinal detachment.

Case report
A 52-year-old female presented with bullous retinal detachment in her left eye, and ultrasound biomicroscopy (UBM) verified the presence of a lesion with ciliary body granulomatous inflammation. The T-SPOT was positive, and the purified protein derivative (PPD) test was strongly positive (diameter of 20 mm). Following the administration of oral anti-tuberculosis regimen combined with prednisone, the retina gradually became reattached, the ciliary body granuloma became significantly reduced in size, and the visual acuity of the patient noticeably improved.

Conclusions
Tuberculous ciliary body granulomas can cause bullous exudative retinal detachment and can be diagnosed with UBM. Early and full-course anti-tuberculosis treatment (ATT) combined with corticosteroid therapy can improve the patient prognosis.