bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unlocking Giant Third‐Order Optical Nonlinearity in (MA)2CuX4 through Introducing Jahn‐Teller Distortion
Authors: Li Bingyue , Li Hui , Wu Chao , Fu LuLu , Boukhvalov Danil W. , Humphrey Mark G. , Zhang Chi , Huang Zhipeng 
Published: May 2024

AbstractNonlinear absorption coefficient and modulation depth stand as pivotal properties of nonlinear optical (NLO) materials, while the existing NLO materials exhibit limitations such as low nonlinear absorption coefficients and/or small modulation depths, thereby severely impeding their practical application. Here we unveil that introducing Jahn–Teller distortion in a Mott‐Hubbard system, (MA)2CuX4 (MA=methylammonium; X=Cl, Br) affords the simultaneous attainment of a giant nonlinear absorption coefficient and substantial modulation depth. The optimized compound, (MA)2CuCl4, demonstrates a nonlinear absorption coefficient of (1.5±0.08)×105 cm GW−1, a modulation depth of 60 %, and a relatively low optical limiting threshold of 1.22×10−5 J cm−2. These outstanding attributes surpass those of most reported NLO materials. Our investigation reveals that a more pronounced distortion of the [CuX6]4− octahedron emerges as a crucial factor in augmenting optical nonlinearity. Mechanism study involving structural and spectral characterization along with theoretical calculations indicates a correlation between the compelling performance and the Mott‐Hubbard band structure of the materials, coupled with the Jahn–Teller distortion‐induced d‐d transition. This study not only introduces a promising category of high‐performance NLO materials but also provides novel insights into enhancing the performance of such materials.
The synthesis, structure, and catalytic properties of Cl‐substituted tridentate ONO Schiff base molybdenum(VI) complexes: Expeditious synthesis of 1,8‐dioxo‐octahydro‐xanthene derivatives
Authors: Li Xinran , Li Tong , Zhuo Zihan , Li Liping , Fu Rao , Yu Honglei , Jin Juan , Gao Xiuwei , Wang Weili , Jin Guanghua 
Published: May 2024

A family of molybdenum complexes with a general formula of [MoO2L]2 have been synthesized and fully characterized, where L is a tridentate ONO Schiff base ligand featuring a Cl substituent in different positions on the aromatic ring of salicylidene‐2‐aminophenolato backbone. The solvent molecule stabilized the monomeric structure of [MoO2LD] (D = DMF or DMSO) allowing single‐crystal X‐ray diffraction of the three new complexes. The dimeric complexes are utilized to catalyze the reaction of aldehydes/ketones with dimedone, leading to 1,8‐dioxo‐octahydro‐xanthene derivatives in N,N‐dimethylformamide. We found that their catalytic activity is enhanced by the electron‐withdrawing group of the Cl substituent on the ONO ligand. In addition, the position of the Cl substituent can also positively influence the catalysis performance: (ortho (L1) > para (L3) > meta (L2) ≈ meta (L4)). The high efficiency of the catalysts promises high yields and selectivity with a low catalyst loading and allows a wide substrate scope of aldehydes/ketones for the reaction. In addition, the method employs recrystallization for purifying products and can be easily scaled up to gram levels, indicating a strong potential for industrial utilization.
Two Broad Categories Overlapping With Rheumatoid Arthritis Observed in Synovial Biopsies from Patients With Juvenile Idiopathic Arthritis
Authors: Triaille Clément , Tilman Gaëlle , Baert Charlotte A. , Sokolova Tatiana , Loriot Axelle , Nzeusseu‐Toukap Adrien , Meric de Bellefon Laurent , Galant Christine , Boulanger Cécile , Fonseca Joao E. , Bouzin Caroline , Durez Patrick , Lauwerys Bernard R. , Limaye Nisha 
Published: May 2024

ObjectiveThe objective is to characterize transcriptomic profiles and immune cell composition and distribution in juvenile idiopathic arthritis (JIA) synovial biopsies, assess for associations of these features with clinical parameters, and compare JIA and rheumatoid arthritis (RA) synovial features.MethodsRNA sequencing (RNASeq) was performed on 24 samples, with pathway analysis and inference of relative abundance of immune cell subsets based on gene expression data. Two multiplex fluorescence immunohistochemistry (IHC) panels were performed on 28 samples (including 13 on which RNASeq was performed), staining for CD206− classical and CD206+ nonclassical macrophages, and CD8+ and CD4+ T and B lymphocytes. Data were compared to a published series of early RA synovial biopsies.ResultsPathway analysis of the most variably expressed genes (n = 339) identified a B and plasma cell signature as the main driver of heterogeneity in JIA synovia, with strong overlap between JIA and RA synovitis. Multiplex IHC confirmed heterogeneity of immune cell infiltration. M1‐like macrophage–rich synovial lining was associated with greater lining hypertrophy and higher (CD45+) pan–immune cell and CD8+ T cell infiltration.ConclusionOur study indicates significant similarities between JIA and RA synovitis. Similar to RA, JIA synovia may be broadly categorized into two groups: (1) those with an inflammatory/adaptive immune transcriptomic signature, M1‐like macrophage and CD8+ T cell infiltration, and thicker, M1‐like macrophage–rich synovial lining, and (2) those with an M2‐like macrophage transcriptomic signature, greater M2/M1‐like macrophage ratios, and thinner, M2‐like macrophage–rich synovial lining. Synovial features were not significantly associated with clinical parameters, likely because of group size and heterogeneity.
Child and caregiver predictors of primary caregiver participation in families of school‐aged Autistic children
Authors: Davy Gemma , Barbaro Josephine , Unwin Katy , Clark Megan , Jellett Rachel , Date Perrin , Muniandy Melanie , Dissanayake Cheryl 
Published: May 2024

AbstractEngaging in meaningful activities (e.g., leisure, spiritual, fitness) significantly affects caregivers' quality of life (QoL), yet the determinants of participation in caregivers of Autistic children remain largely unknown. The current study examined child and caregiver correlates of primary caregiver participation in meaningful activities. One hundred and six primary caregivers of Autistic children (7–12 years) were recruited from three unique cohorts of Autistic children in this cross‐sectional study. Primary caregivers completed online questionnaires measuring occupational gaps (i.e., desired activities caregivers are not participating in), QoL, parenting stress, perceived family outcomes, and social support. In addition to undertaking direct assessments of children's cognition and language, primary caregivers also reported on their child's adaptive behavior, social–emotional skills, and participation. Caregivers reporting fewer occupational gaps (i.e., ≤2 desired activities) were more likely to have Autistic children with no co‐occurring conditions, who were older, and with better adaptive behaviors, social–emotional skills, and more frequent home and school participation, compared to caregivers reporting many gaps (i.e., ≥3 desired activities). Caregivers with fewer occupational gaps also reported improved QoL, parenting stress, social support, perceived community inclusiveness, and family outcomes. Logistic regression analysis identified child age, child adaptive behavior, social–emotional skills, home participation, and the caregivers' perceived family outcomes and QoL as important predictors of their occupational gaps. The findings demonstrate that caregiver participation in desired activities was associated with increased functional ability and independence of the child, as well as their perceived capacity to meet their child's needs. Supporting parents' sense of efficacy in meeting their children's needs and building their skills and knowledge will serve to improve both caregiver and child outcomes.
Compatibility of Molybdenum Disulfide and Magnesium Fluorinated Alkoxyaluminate Electrolytes in Rechargeable Mg Batteries
Authors: Falyouna Omar , Faizul Idham Mohd , Eljamal Osama , Mandai Toshihiko 
Published: May 2024

AbstractMolybdenum disulfide (MoS2)‐based cathodes have exhibited good electrochemical reactions in all phenyl complex (APC) electrolytes. However, APC electrolytes are highly corrosive and susceptible to oxidation. Alternatively, magnesium fluorinated alkoxyaluminate electrolyte (Mg[Al(HFIP)4]2) is a pioneering chloride‐free electrolyte with remarkable electrochemical activity in rechargeable Mg batteries (RMBs). This study aims to investigate the compatibility of various MoS2 nanomaterials with Mg[Al(HFIP)4]2 in RMBs. Seven MoS2 nanomaterials were synthesized under different hydro/solvothermal conditions and evaluated as cathode materials in RMBs. The results revealed that the electrochemical activity of the as‐synthesized MoS2 in RMBs significantly varied and MoS2 with high content of 1T‐phase (M5) exhibited the best specific capacity of ca. 35 mAh g−1. Heteroatom doping, graphene oxide (GO) incorporation, and dual‐salt electrolytes were employed to enhance the electrochemical performance of M5. The electrochemical tests showed that all doped‐MoS2 and GO‐MoS2 delivered poor specific capacities (<20 mAh g−1), properly due to the disorder of the cathode material and the entrapment of Mg2+ ions. In contrast, dual‐salt electrolytes (0.3 M Mg[Al(HFIP)4]2/0.3 M LiCl) improved the initial specific capacity by 242 %. This is attributed to the preferential intercalation of Li+ ions that reduces the diffusion energy barrier and facilitates the intercalation of Mg+2 ions.
Characteristics and management of post‐circumcision Urethrocutaneous Fistula: a retrospective study in surgical units in Cameroon
Authors: Mbouche Landry Oriole , Mbassi Achille Aurèle , Mekeme Junior Barthelemy Mekeme , Bob Dorcas Nyanit , Ndjock Joseph Lionel , Tamufor Emmanuel Njuma , Tambo Faustin Mouafo 
Published: May 2024

AbstractBackgroundUrethrocutaneous fistula (UCF) is one of the major complications of circumcision. The risk factors associated with UCF are not clear‐cut but its repair remains a challenge for urological surgeons. The aim of this study was to highlight the epidemiological, and clinical features and outcomes obtained from the management of UCF in the context of a country with limited medical resources where ritual circumcision is widely practiced.Patients and methodsFrom February 2010 to December 2022, 35 patients underwent surgical repair for post‐circumcision UCF in two tertiary hospitals in Yaounde, Cameroon. Simple closure, Thiersch‐Duplay‐Snodgrass and Mathieu techniques were performed.ResultsThe mean age of patients was 7.4 ± 4.1 years with a range of 2 to 21 years; the median age at circumcision was 24 months (12; 48). Most (95%) of circumcisions were performed by paramedical staff. The majority of patients (n = 26) consulted for a bifid stream, Three‐quarters of fistulae were located at the corona. Small fistulae represented 74.28% (n = 26) of cases as opposed to large fistulae (25.71%). More than 70% of patients underwent a simple closure. The therapeutic results were satisfactory in 91.4% of cases (n = 32) after an average follow‐up of 91.85 ± 51.92 months. There were no statistically significant differences between the patients with coronal fistula and patients with distal penile fistula concerning demographic, clinical and surgical characteristics.ConclusionUrethrocutaneous fistula is a major and frequent complication of circumcision mostly practiced by non‐qualified personnel on children aged 24 months. The usual presentation is micturition with a bifid stream occurring on average 3 months after circumcision. Coronal fistulas are the commoner location. Simple closure, Thiersch‐Duplay‐Snodgrass and Mathieu technique appear to be safe with the advantages of low recurrence rate. An accurate diagnosis with a timeframe respecting the principles of fistula surgery combined with regular follow‐up is mandatory for good long‐term results with a low recurrence rate. Further prospective studies on the factors affecting the formation of urethrocutaneous fistula should be performed to prevent this complication of circumcision.
The impact of the route to diagnosis in nephroblastoma
Authors: Mergen Marvin , Welter Nils , Furtwängler Rhoikos , Melchior Patrick , Vokuhl Christian , Gessler Manfred , Meier Clemens‐Magnus , Kager Leo , Schenk Jens‐Peter , Graf Norbert 
Published: May 2024

AbstractIntroductionWilms tumor (WT) is the most common childhood kidney cancer. It is a rapid growing embryonal tumor in young children and can be diagnosed with and without tumor related symptoms.MethodsWe retrospectively analyzed the route to diagnosis of WT treated prospectively according to the SIOP 93‐01/GPOH and 2001/GPOH in Germany between 1993 and 2022. Four routes were defined: diagnosis due to tumor‐related symptoms, incidental diagnosis during another disease, diagnosis by preventive examinations, and diagnosis within a surveillance program. For these groups we compared clinical and tumor characteristics and outcome.ResultsOf 2549 patients with WT 1822 (71.5%) were diagnosed by tumor‐related symptoms, 472 (18.5%) incidentally, 213 (8.4%) by preventive medical examinations, and 42 (1.6%) by surveillance. Age, general health status, tumor volume, and local and overall stage varied significantly between these groups. The youngest patients were those diagnosed by preventive medical examination (mean: 1.70 years). These patients also showed the best general health status. Tumor volume at diagnosis (549 mL) and after preoperative chemotherapy (255 mL) was significantly higher for children with tumor‐related symptoms. The highest percentage of local stage I (78.6%) and the lowest percentage of metastatic disease (4.8%) was found in the surveillance group. The outcome of patients was not significantly different, with up to 19.0% relapses in the surveillance group and 3.0% deaths in the group with tumor‐related symptoms.ConclusionThe route to diagnosis of WT correlates with age, general health status, tumor volume, and stage distribution, but does not impact the outcome of patients. Nonetheless, diagnosis without tumor related symptoms results in lower treatment burden and thus improved quality of life.
Efficacy and safety of eribulin mesylate in patients with locally advanced or metastatic breast cancer previously treated with anthracycline/taxanes
Authors: Chen Lan , Yan Xi , Luo Ting , Tian Tinglun , He Ping , Zhong Xiaorong 
Published: May 2024

AbstractBackgroundThis prospective real‐world study aimed to assess the efficacy and safety of eribulin in the clinical practice against advanced breast cancer (ABC) in China.Patients and MethodsIn this study, eligible patients with inoperable locally advanced or metastatic breast cancer who had experienced prior neo−/adjuvant or failed the palliative treatment with anthracycline/taxanes were included. Eribulin (1.4 mg/m2) was infused intravenously on Day 1 and Day 8 every 3 weeks until disease progression or intolerable toxicity occurred. The progression‐free survival (PFS), overall response rate (ORR), disease control rate (DCR), and safety of the treatment were assessed.ResultsOne hundred and thirty‐four patients were enrolled. The median PFS (mPFS) was 4.3 months (95% CI: 0.3–15.4). The ORR and DCR was 32.1% and 79.1%, respectively. The mPFS of patients who received eribulin as first‐ or second‐line treatment was significantly better than those who received eribulin as ≥3‐line treatment (6.9 months [95% CI: 3.2–8.8] vs. 4.0 months [95% CI: 3.4–4.6], p = 0.006). The mPFS of patients with triple‐negative, HER2‐positive, and HER2(−)/HR(+) was 3.4 (95% CI: 2.7–4.1), 6.2 (95% CI: 2.3–10.1) and 5.0 months (95% CI: 4.1–5.9), respectively. HER2(+) patients had significantly longer PFS than TNBC patients (p = 0.022). Patients received combination therapy had a significantly longer mPFS than those who received eribulin monotherapy (5.0 months [95% CI 3.6–6.3] vs. 4.0 months [95% CI: 3.3–4.7] [p = 0.016]). Multivariate analysis revealed that MBC patients with a molecular typing of non‐TNBC receiving eribulin as ≤2‐line therapy and combination therapy had a low risk of disease progression. Neutropenia (33.58%), leukopenia (11.94%), and thrombocytopenia (4.48%) were the most common treatment‐related adverse events.ConclusionEribulin demonstrated effective clinical activity and a favorable tolerability profile in Chinese patients with ABC in the real‐world. The efficacy and safety profile were consistent with those reported in previous randomized phase 3 trials.
Identification of the molecular subtypes and signatures to predict the prognosis, biological functions, and therapeutic response based on the anoikis‐related genes in colorectal cancer
Authors: Zhai Xiang , Chen Baoxiang , Hu Heng , Deng Yanrong , Chen Yazhu , Hong Yuntian , Ren Xianghai , Jiang Congqing 
Published: May 2024

AbstractBackgroundTumors that resist anoikis, a programmed cell death triggered by detachment from the extracellular matrix, promote metastasis; however, the role of anoikis‐related genes (ARGs) in colorectal cancer (CRC) stratification, prognosis, and biological functions remains unclear.MethodsWe obtained transcriptomic profiles of CRC and 27 ARGs from The Cancer Genome Atlas, the Gene Expression Omnibus, and MSigDB databases, respectively. CRC tissue samples were classified into two clusters based on the expression pattern of ARGs, and their functional differences were explored. Hub genes were screened using weighted gene co‐expression network analysis, univariate analysis, and least absolute selection and shrinkage operator analysis, and validated in cell lines, tissues, or the Human Protein Atlas database. We constructed an ARG‐risk model and nomogram to predict prognosis in patients with CRC, which was validated using an external cohort. Multifaceted landscapes, including stemness, tumor microenvironment (TME), immune landscape, and drug sensitivity, between high‐ and low‐risk groups were examined.ResultsPatients with CRC were divided into C1 and C2 clusters. Cluster C1 exhibited higher TME scores, whereas cluster C2 had favorable outcomes and a higher stemness index. Eight upregulated hub ARGs (TIMP1, P3H1, SPP1, HAMP, IFI30, ADAM8, ITGAX, and APOC1) were utilized to construct the risk model. The qRT‐PCR, Western blotting, and immunohistochemistry results were consistent with those of the bioinformatics analysis. Patients with high risk exhibited worse overall survival (p < 0.01), increased stemness, TME, immune checkpoint expression, immune infiltration, tumor mutation burden, and drug susceptibility compared with the patients with low risk.ConclusionOur results offer a novel CRC stratification based on ARGs and a risk‐scoring system that could predict the prognosis, stemness, TME, immunophenotypes, and drug susceptibility of patients with CRC, thereby improving their prognosis. This stratification may facilitate personalized therapies.
Impact of different respiratory gating methods on target delineation and a radiotherapy plan for solitary pulmonary tumors
Authors: Shang Dongping , Duan Jinghao , Yin Yong , Wang Ruozheng 
Published: May 2024

AbstractBackground and PurposeRespiratory movement has an important impact on the radiotherapy for lung tumor. Respiratory gating technology is helpful to improve the accuracy of target delineation. This study investigated the value of prospective and retrospective respiratory gating simulations in target delineation and radiotherapy plan design for solitary pulmonary tumors (SPTs) in radiotherapy.MethodsThe enrolled patients underwent CT simulation with three‐dimensional (3D) CT non gating, prospective respiratory gating, and retrospective respiratory gating simulation. The target volumes were delineated on three sets of CT images, and radiotherapy plans were prepared accordingly. Tumor displacements and movement information obtained using the two respiratory gating approaches, as well as the target volumes and dosimetry parameters in the radiotherapy plan were compared.ResultsNo significant difference was observed in tumor displacement measured using the two gating methods (p > 0.05). However, the internal gross tumor volumes (IGTVs), internal target volumes (ITVs), and planning target volumes (PTVs) based on the retrospective respiratory gating simulation were larger than those obtained using prospective gating (group A: pIGTV = 0.041, pITV = 0.003, pPTV = 0.008; group B: pIGTV = 0.025, pITV = 0.039, pPTV = 0.004). The two‐gating PTVs were both smaller than those delineated on 3D non gating images (p < 0.001). V5Gy, V10Gy, V20Gy, V30Gy, and mean lung dose in the two gated radiotherapy plans were lower than those in the 3D non gating plan (p < 0.001); however, no significant difference was observed between the two gating plans (p > 0.05).ConclusionsThe application of respiratory gating could reduce the target volume and the radiation dose that the normal lung tissue received. Compared to prospective respiratory gating, the retrospective gating provides more information about tumor movement in PTV.
Impulse buying in the digital age: An exploration using systematic literature review approach
Authors: Kaur Kawaljeet , Sharma Tejinder 
Published: May 2024

AbstractThe article synthesizes online impulse buying research conducted through a systematic literature review (SLR) approach. The present review covers the diverse range of literature, from 2001 to 2024, conducted using the SPAR‐4‐SLR protocol. Drawing upon the theory‐context‐characteristics‐method (TCCM) framework, a literature synthesis provides an overview of article's descriptives, underpinning theories, contextual overview and methodological aspects. The review also highlights the variables related to the antecedents, mediators, moderators and consequences of online impulse buying and proposes the integrated conceptual framework of the concept. Lastly, the review highlights the gap in the literature and offers insightful directions to advance research in online impulse buying domain. Overall, this review is an attempt to make significant theoretical and practical contributions to the field of online impulse buying research.
Design, Synthesis and Antibacterial Assessment of Active (4‐Arylazo‐3‐Methyl‐2‐Thienyl) 4‐Antipyrine Ketones
Authors: Barakat Khouloud M. , Adel Elsayed Shymaa , Yılmaz Murat , Abdel‐Latif Ehab , Etman Hassan Ali , Hamed Mohamed A. , El Nemr Ahmed 
Published: May 2024

AbstractThe chemicals formed from antipyrines are flexible organic building blocks that are employed in the development of pharmaceuticals. By diazotizing (4‐arylazo‐3‐hydroxy‐2‐thienyl) 4‐antipyrine ketones 1a, 1b and 1c and (4‐arylazo‐3‐methyl‐2‐thienyl) 4‐antipyrine ketones (2a, 2b and 2c) further replaced with six other coupling components, a broad spectrum of hybrid molecules have been created. Mass spectra, NMR, FTIR, and elemental analyses have all been used to confirm the structures of the synthesised compounds. The antimicrobial screening was investigated by agar well diffusion and diluting the broth technique against both Gram‐negative and positive‐tested bacterial strains. (3‐methyl‐5‐(phenylamino)‐4‐(4‐tolylazo)‐2‐thienyl) 4‐antipyrine ketone (2a) was found to be superior to Ciprofloxacin against test strains: Acinetobacter sp (34.33±1.15 mm), Listeria monocytogenes (29.33±1.15 mm) and Streptococcus sp. (19.33±1.15 mm). Also, good to moderate activities were expressed as minimum inhibitory concentration (MIC) and minimum bacterial concentration (MBC) which were recorded at 9±1 to 59.67±4.51 μg/mL and 16±4 to >512 μg/mL, respectively, using compounds 2a, 2b, and 2c. MBC/MIC ratio showed, that only, 2a and 2b have a bactericidal effect but other antipyrines with bacteriostatic strength. To conclude, it was suggested that the use of these novel synthesized (4‐arylazo‐3‐methyl‐2‐thienyl) 4‐antipyrine ketone derivatives molecules as a new chemical class of antimicrobial agents to perform new drug discovery in pharmaceutical preparations and medicinal research.