bluuebunny/crossref_metadata_2025_split huggingface dataset:
Challenges in Ventricular Arrhythmia Ablation: Difficult Substrates and Advanced Ablation Strategies
Authors: Zarębski Łukasz , Futyma Piotr 
Published: April 2024

Abstract
Purpose of review
During challenging scenarios of ventricular arrhythmia (VA) ablation, novel strategies to target the arrhythmogenic substrate are sometimes essential for clinical success. While catheter ablation (CA) can offer relatively high efficacy, it may not always lead to complete VA eradication in certain individuals. This article provides a brief overview of difficult substrate ablation strategies in patients with premature ventricular contractions (PVC) or ventricular tachycardia (VT) and explores methods to improve outcomes for cases that do not respond to typical ablation techniques.

Recent findings
Recent developments highlight the crucial role of advanced imaging and mapping techniques in the visualization, characterization, and localization of challenging ventricular substrates. Additionally, some novel and advanced ablation strategies may be useful when PVC/VT is refractory to conventional ablation treatment.

Summary
An expanding spectrum of techniques which can optimize the precision and effectiveness of catheter ablation procedures may improve PVC/VT ablation outcomes. Novel ablation therapies such as alcohol ablation, optimization of dispersive patch positions, or bipolar ablation, can overcome obstacles associated with the challenging anatomy of arrhythmia.
How appropriate is treating patients diagnosed with advanced esophageal cancer with anticancer drugs? A multicenter retrospective cohort Spanish study
Authors: Santero Marilina , Requeijo Carolina , Quintana Maria Jesus , Rodríguez Dulce , Bottaro David , Macias Ismael , Pericay Carles , Farina Natalie , Blanco Jesus Manuel , Urreta-Barallobre Iratxe , Punti Laura , Nava Maria Angeles , Bonfill Cosp Xavier 
Published: April 2024

Abstract
Aim
To assess the appropriateness of systemic oncological treatments (SOT) provided to patients diagnosed with advanced esophageal cancer (EC) across a group of participating hospitals.

Methods
Multicenter, retrospective cohort study in five Spanish hospitals including newly confirmed advanced EC cases between July 1, 2014, and June 30, 2016, with a 5-year follow-up.

Results
We identified 157 patients fulfilling the inclusion criteria (median age: 65 years, 85.9% males). Most patients, 125 (79.6%) were treated at least with one active treatment, and 33% received two or more lines of SOT. The 1-, 2- and 5-year overall survival rates were 30.3% [95%CI: 23.8, 38.7], 14.0% [95%CI: 9.3, 21.0], and 7.1% [95% CI: 3.8, 13.1] respectively, and the median survival time 8 months (95% CI: 6, 19) for stages IIIb IIIc and 7 months (95% CI: 5, 9) for stage IV. Clinical stage, receiving more than one line of SOT, and treatment with radiotherapy accelerated the time to death (0.4, 0.9-, and 0.8-times shorter survival respectively, p < 0.05). Better performance status (ECOG < 2) extended survival time by 2.2 times (p = 0.04). Age < 65 years (OR 9.4, 95% CI 3.2, 31.4, p < 0.001), and being treated in one particular hospital (OR 0.2, 95% CI 0.0, 0.8, p < 0.01) were associated with the administration of two or more lines of SOT. Altogether, 18.9% and 9.0% of patients received chemotherapy in the last four and two weeks of life, respectively. Moreover, 2.5% of patients were prescribed a new line of chemotherapy during the last month of life. The proportion of all patients who did not have access to palliative care reached 29.3%, and among those who had access to it, 34.2% initiated it in the last month of life.

Conclusion
A high proportion of advanced EC patients receive many treatments not based on sound evidence and they do not benefit enough from palliative care services. The most accepted appropriateness indicators point out that some of the analyzed patients could have been overtreated. This study provides important insights into the quality of care provided to advanced EC, and furthermore, for giving valuable insight and opportunities for improvement.
Social Theory and Transgender: Beyond Polarization
Authors: Turner Charles 
Published: April 2024

AbstractThis paper argues that social theory can cast light on some of the main themes in current debates about trans issues. It considers four such themes: social classification and social control; tensions between individual and group rights; access to public spaces; and the relationship between personal pronouns and social identity. In so doing, it seeks to reframe local disagreement and polemic through more general questions about our modes of living together, and concludes that these debates are at bottom about the future of civility.
Flight control design for a hypersonic waverider configuration: A non-linear model following control approach
Authors: Autenrieb Johannes , Fezans Nicolas 
Published: April 2024

Abstract
DLR is currently investigating the potential of hypersonic flight systems in the context of different mission scenarios. One configuration type of higher interest for civil and military purposes is the hypersonic glide vehicle (HGV). Such HGVs operate over broad flight envelopes and pose complex flight dynamic characteristics. This article presents DLR’s generic hypersonic glide vehicle 2 (GHVG-2) and proposes an integrated non-linear flight control architecture that is based on the idea of the non-linear dynamic inversion and non-linear model following control methodologies. The proposed control scheme is designed to sufficiently and robustly handle the system dynamics of the over-actuated flight vehicle. The approach is first discussed, and the performance of the suggested control laws is later investigated via simulations of a high-fidelity non-linear flight dynamic model in the nominal case and under the presence of parametric uncertainties. The presented results demonstrate that the proposed NMFC approach provides benefits for the robust control of the regarded hypersonic system.
Structural correlation and chemistry of molten NaF–ScF3 with dissolved metal aluminium: TG/DTA, XRD, NMR and molecular dynamics simulations
Authors: Rakhmatullin Aydar , Šimko František , Zanghi Didier , Netriová Zuzana , Polovov Ilya B. , Dimiev Ayrat , Maksimtsev Konstantin V. , Bessada Catherine , Korenko Michal 
Published: April 2024

AbstractFor the first time, the mechanism of metal aluminum dissolution in NaF–ScF3 eutectic melts and the chemical interaction between the constituents of this mixture have been thoroughly studied by a combination of differential thermal analysis (DTA), high temperature and solid-state nuclear magnetic resonance (NMR), and X-ray diffraction (XRD) coupled with the molecular dynamic simulations. The formation of an insoluble Al3Sc alloy in molten (NaF–ScF3)eut system was proven, and the chemical mechanism of this aluminothermic Al3Sc alloy production was elucidated. Corresponding ex situ examinations bring to light the formation of NaScF4 and solid solution of Na3(Al,Sc)F6 in cooled bath. The molecular dynamics calculations of the bath allow us to construct the structural model and to predict viscosity, density and electrical conductivity of the reagent melt to help to optimize the conditions of the alloy synthesis.
Graphical abstract
An endothelial-related prognostic index for bladder cancer patients
Authors: Li Deng-xiong , Wu Rui-cheng , Wang Jie , Yu Qing-xin , Tuo Zhou-ting , Ye Lu-xia , Feng De-chao , Deng Shi 
Published: April 2024

Abstract
Background
Within the tumor microenvironment, endothelial cells hold substantial sway over bladder cancer (BC) prognosis. Herein, we aim to elucidate the impact of endothelial cells on BC patient outcomes by employing an integration of single-cell and bulk RNA sequencing data.

Methods
All data utilized in this study were procured from online databases. R version 3.6.3 and relevant packages were harnessed for the development and validation of an endothelial-associated prognostic index (EPI).

Results
EPI was formulated, incorporating six genes (CYTL1, FAM43A, GSN, HSPG2, RBP7, and SLC2A3). EPI demonstrated significant prognostic value in both The Cancer Genome Atlas (TCGA) and externally validated dataset. Functional results revealed a profound association between EPI and endothelial cell functionality, as well as immune-related processes. Our findings suggest that patients with low-risk EPI scores are more likely to respond positively to immunotherapy, as indicated by immune checkpoint activity, immune infiltration, tumor mutational burden, stemness index, TIDE, and IMvigor210 analyses. Conversely, individuals with high-risk EPI scores exhibited heightened sensitivity to cisplatin, docetaxel, and gemcitabine treatment regimens.

Conclusion
We have effectively discerned pivotal genes from the endothelial cell perspective and constructed an EPI for BC patients, thereby offering promising prospects for precision medicine.
Factors Influencing the Provision of Healthcare Professional-Led Sexual Support to Patients with Cancer and Their Partners: An Integrative Review of Studies from 2017 to 2022
Authors: Bingham Sharon Linsey , Cassells Claire Victoria , Semple Cherith Jane 
Published: April 2024

Abstract
Introduction
Patients with cancer and partners often face difficult and enduring sexual concerns. Reviews up to 2017 identified that the provision of a healthcare professional (HP)-led sexual support was not routine practice. Since 2017, there has been a burgeoning growth in research and evidenced-based interventions targeting HP’s sexual support provision in cancer care. Therefore, this review presents a synthesis of HP-led sexual support and factors impacting provision in cancer care from 2017 to 2022 to ascertain if sexual support in clinical practice has changed.

Methods
Using an integrative review design, searches were performed on five electronic databases (CINAHL, MEDLINE, ProQuest, PubMed and PsycInfo), Google Scholar and manual review of reference lists from 2017 to 2022. Data extracted from studies meeting predefined inclusion/exclusion criteria was synthesised using thematic analysis. Papers were appraised using the Mixed Methods Appraisal Tool.

Results
From the twelve empirical studies included, three themes were identified: (1) Theory–practice gap: HP’s recognition of the need to provide sexual support to patients with cancer and partners but current provision is lacking, (2) professional and organisational barriers to HPs providing sexual support for patients with cancer and (3) equipping HPs and enabling patients to discuss sexual challenges in cancer care could enhance delivery of sexual support.

Conclusion
Provision of HP-led sexual support in cancer care is still not routine practice and when provided is considered by HPs as sub-optimal.

Policy Implications
Providing HPs with education, supportive resources and referral pathways could enhance the provision of sexual support in cancer care.
Development and field application of strongly resilient temporary plugging diversion agent for fracturing
Authors: Liu Yi , Chen Renbao , Liu Jing , Yu Yangyang , Zhu Kuanliang 
Published: April 2024

AbstractTemporary plugging diversion fracturing in multistage horizontal well is normally used to improve stimulation efficiency and increase production in unconventional reservoirs. Temporary plugging agent plays an important role in diversion fracturing. A strongly resilient temporary plugging diversion agent can improve the effectiveness of fracturing diversion. Therefore, a novel organosilicon temporary plugging diversion agent (QBZU) was developed through micellar copolymerization method. Self-synthesized strongly resilient temporary plugging diversion agent (QBZU gel) was prepared by using acrylamide, N, N′-methylene bisacrylamide, surfactants, organosilicon, ammonium persulfate and sodium bisulfite as chemical raw materials. The micellar copolymerization is investigated to overcome the incompatibility of hydrophobic organosilicon and water-soluble monomer by adding some appropriate surfactants. The experimental results indicated that the combination of sodium dodecyl sulphonate and Tween 80 provided excellent copolymerization results. The characteristics of compressive resistance, salt resistance, shearing resistance, resilience and degradation are superior compared with traditional rigid granular temporary plugging agent widely used in oilfields (QG hydrogel). According to the experimental evaluation results of QBZU, its pressure-bearing capacity can reach 56.3MPa, shearing strength can reach 410N, elastic modulus can reach 80MPa, and Poisson ratio can reach 0.48. Meanwhile, the main synthetic factors affecting the resilient performance of QBZU were investigated, including polymer concentration, organosilicon concentration and the types of surfactant. Based on the fracturing pressure curve and microseismic monitoring results, the plugging and fracture diversion effectiveness was further confirmed.
Rituximab potentially improves clinical outcomes of CAR-T therapy for r/r B-ALL via sensitizing leukemia cells to CAR-T-mediated cytotoxicity and reducing CAR-T exhaustion
Authors: Li Yangzi , Cui Qingya , Liu Sining , Liu Lingling , Li Megyn , Gao Jun , Li Zheng , Cui Wei , Zhu Xiaming , Kang Liqing , Yu Lei , Wu Depei , Tang Xiaowen 
Published: April 2024

Abstract
Purpose
Despite chimeric antigen receptor (CAR) T-cell therapy has achieved great advances in recent year, approximately 50% of relapsed/refractory B cell acute lymphoblastic leukemia (r/r B-ALL) patients treated with CAR-T experience relapse 6 months post CAR-T treatment. CD20 express on 30 to 50% of B-ALL, which makes CD20 Monoclonal Antibody as one of the potential therapy strategies to decrease the tumor burden and improve the efficacy of CAR-T therapy. Adding Rituximab to chemotherapy protocol had been demonstrated to improve the outcome for CD20-positive ALL. However, rare study explored the influence of Rituximab combined with CAR-T therapy.

Methods
We retrospectively analyzed 20 r/r B-ALL patients who received CAR-T therapy, all of whom had failed multiple lines of therapy. Before CAR-T infusion, we administered Rituximab to 10 patients with high CD20 expression at a dose of 375 mg/m2 for 1 day. Meanwhile, we selected 10 patients with the comparable features who underwent CAR-T treatment without Rituximab in the same period as the control group. In vitro, the surface molecule expression and killing of CAR-T post Rituximab-treated B-ALL cells co-incubated with CAR-T cells were detected by flow cytometry.

Results
The median follow-up of Rituximab and Control groups were 29.27 and 9.83 months. We found that adding Rituximab may confer a favorable prognosis compared with Control group. The 2-year overall survival (OS) and leukemia-free survival (LFS) rates both were longer in the Rituximab group (90% vs. 26.7%, p = 0.0342; 41.7% vs. 25%, p = 0.308). In vitro, we observed that Rituximab-treated tumour cells are more sensitive to CAR-T killing and a broad range of cytokines and chemokines were produced when Rituximab-treated Nalm-6 cells co-cultured with 19-22CAR-T cells, such as interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α) and interleukin-2 (IL-2). To investigate whether Rituximab has an effect on CAR-T persistence, we stimulated CAR-T cells repeatedly in vitro with Rituximab-treated Nalm-6 to evaluate the changes in CAR-T surface exhaustion molecules at different times. We found that the expression of exhaustion molecules (LAG-3, PD-1, TIM-3) on CAR-T cells were significantly lower in the Rituximab group than in the Control group.

Conclusion
Rituximab combined with CAR-T therapy is effective for improving the long-term prognosis of B-ALL patients who have failed multiple lines of therapy. In vitro, we observed that rituximab potentially improves CAR-T efficacy by sensitizing ALL to CART-mediated cytotoxicity and reducing CAR-T exhaustion.
One-misrecorded Poisson INAR(1) model via two random operators with application to crime and economics data
Authors: Gabr M. M. , Bakouch Hassan S. , El-Hadidy Shimaa M. 
Published: April 2024

AbstractIn this paper, we propose a first-order non-negative integer-valued autoregressive (INAR(1)) model with one-misrecorded Poisson (OMP) marginal via a combination of the generalized binomial thinning and mixture Pegram operators for zero-inflated and one deflated count time series. The suggested model is suitable for multimodal, equi- and over-dispersed data modeling. It contains two particular cases: the mixture of Pegram and thinning of a first-order integer-valued autoregressive (MPT(1)) with Poisson and one-misrecorded Poisson. The distribution of the innovation term is derived as a mixture of degenerate distributions at 0 and 1, and two Poisson distributions with certain parameters. Regression and several statistical properties of the proposed model are discussed. We investigate the distribution of the runs (the lengths of zeros and ones). The parameters of the model are estimated using the maximum-likelihood, modified Yule–Walker, and modified conditional least squares methods. The estimation of the parameters, their behavior, and their performance are presented through a simulation study. Two practical data sets on the monthly cases of criminal records and weekly sales are applied to check the proposed process’s performance against other relevant INAR(1) models, showing its capabilities in the challenging case of over-dispersed count data. Furthermore, the proposed model discusses data forecasting.
Understanding Typing Skill in Students With Developmental Disorders
Authors: Barnett Anna L. , Stuart Nichola 
Published: April 2024

Abstract
Purpose of Review
Typing is an important skill for education and beyond and is often recommended for those with developmental coordination disorder (DCD) and/or specific learning disorder (SLD) when handwriting is a challenge. This review outlines a model of typing to demonstrate the language, perceptual, and motor components involved. It then summarises selected research on typing skill in DCD and SLD. The purpose of the review is to identify current knowledge of typing skill in these groups to enhance understanding and inform future work on assessment, accommodations, and intervention.

Recent Findings
Thirteen relevant studies, published between 2008 and 2024, were identified. These vary widely in the types of disorder/difficulties studied, participant age, and language. They also include a range of tasks (alphabet writing, writing to dictation, copywriting, compositional writing) and employ different measures of typing. Taken together, they examine aspects of the typed ‘product’ (speed and accuracy), the ‘process’ of typing (efficiency, gaze, and finger movements), and student ‘perceptions’ of typing. Despite the varied groups studied and methods employed, findings are consistent. Most studies report that in groups with developmental disorders, typing is poorer than handwriting, and typing is poorer compared to typically developing peers.

Summary
The findings have important implications for research and practice. They indicate the need for further research on typing in specific diagnostic groups. They also emphasise the need for practical tools to assess typing performance across a range of tasks. This will aid the identification of typing difficulties and help plan appropriate accommodations and/or intervention.
An overview of sentence ordering task
Authors: Shi Yunmei , Zhang Haiying , Li Ning , Yang Teng 
Published: April 2024

AbstractThe sentence ordering task aims to organize complex, unordered sentences into readable text. This improves accuracy, validity, and reliability in various natural language processing domains, including automatic text generation, text summarization, and machine translation. We begin by analyzing and summarizing the sentence ordering algorithm from two perspectives: the input data approach and the implementation technique approach. Based on the different ways of input data formats, they are classified into pointwise, pairwise, and listwise, and the advantages, disadvantages and representative algorithmic features of each are discussed. Based on the different implementation technologies, we classify them into sentence ordering algorithms based on learning to rank and deep learning, and the core ideas, typical algorithms and research progress of these two categories of methods were specifically explained. We summarize the datasets and evaluation metrics of currently commonly used sentence ordering tasks. Additionally, we analyze the problems and challenges of sentence ordering tasks and look forward to the future direction of this field.
Design and analysis of ultra-wideband microstrip patch antenna with various conductive materials for terahertz gap
Authors: Singh Kritika , Dhayal Marshal , Dwivedi Smrity 
Published: April 2024

AbstractThe paper explores the design and analysis of a wideband microstrip patch antenna with a metallic patch and a 3 × 3 split ring resonator (SRR) array operating in the 0.1–5 THz frequency range. The antenna's structure incorporates different conductive materials such as gold, silver, and graphene as a metallic patch. The dimensions of the metallic patch and SRR are calculated to achieve wideband operation within the desired THz range. The SRR array enhances electromagnetic resonance, thereby improving bandwidth and radiation characteristics for medical imaging. The study discusses the equivalent circuit and design equations for the microstrip patch antenna and SRR unit cell. For designing and analyzing the proposed antenna, CST Microwave Studio 2019 software have been used. Performance parameters such as return loss, bandwidth, gain, efficiency, directivity, VSWR, and radiation pattern have been evaluated. The advantages and limitations of each conductive material are evaluated to determine their suitability for THz-based medical imaging applications. The goal is to maximize the antenna's bandwidth, gain, and image resolution for medical imaging purposes. The findings highlight the performance characteristics of gold, silver, and graphene as conductive materials for medical imaging applications, facilitating the development of high-resolution, non-invasive imaging systems with improved diagnostic capabilities.