bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Potential Effects and Mechanisms of Rhododendron molle against Rheumatoid Arthritis Based on Network Pharmacology and Molecular Docking
Authors: Zhao Xianxian , Shen Yu , Huang Yongchun , Li Xinyuan , Dai Liangfang , Luo Xiangdong 
Published: June 2024

Background:
Rheumatoid arthritis (RA) is a self-inflammatory disease with increasing
global morbidity and high disability. The Chinese herbal medicine Rhododendron molle G. Dons has
been conventionally used to control RA without side effects for hundreds of years, but its effect and
mechanism for anti-RA are still unclear.

Objective:
The objective of this study is to study the potential effect and mechanism of R. molle
against RA from the perspective of action targets and molecular pathways.

Methods:
In this study, systemic network pharmacology was used to explore the potential effect and
mechanisms of R. molle against RA, including drug active components collection, target prediction,
PPI network construction, and GO and KEGG pathway enrichment analyses. At last, molecular
docking was carried out to estimate the pharmacological effects and mechanisms.

Results:
A total of 19 drug-active compounds from R. molle and 188 potential therapeutic targets for
RA were screened. According to the results of molecular docking, the interaction between 4 key
active compounds (rhodojaponin ???, quercetin, kaempferol, rhodojaponin VI) and 10 core target proteins
(TNF, AKT1, ALB, IL-1β, TP53, EGFR, CASP3, MMP9, PTGS2, BCL2) is the closest. The
results of enrichment analysis showed that the most enriched pathways were pathways related to
inflammation, human T-cell leukemia virus type ??? infection, PI3K-Akt and IL-17.

Conclusion:
The Chinese herbal medicine R. molle may regulate multiple pathways by interacting
with multiple drug-active compounds and core targets, and cause the patient's immune system to
respond accordingly, reducing the release of inflammatory factors, and relieving joint pain.
In silico and In vitro Assessment of Dimeric Flavonoids (Brachydins) on Rhipicephalus microplus Glutathione S-transferase
Authors: dos Santos Bezerra Wallyson André , Tavares Caio Pavão , Lima Victor Antônio Silva , da Rocha Cláudia Quintino , da Silva Vaz Junior Itabajara , Michels Paul A.M. , Costa Junior Livio Martins , dos Santos Soares Alexandra Martins 
Published: June 2024

Introduction:
Rhipicephalus microplus, an important cattle ectoparasite, is responsible
for a substantial negative impact on the economy due to productivity loss. The emergence of resistance
to widely used commercial acaricides has sparked efforts to explore alternative products
for tick control.

Methods:
To address this challenge, innovative solutions targeting essential tick enzymes, like
glutathione S-transferase (GST), have gained attention. Dimeric flavonoids, particularly brachydins
(BRAs), have demonstrated various biological activities, including antiparasitic effects. The objectives
of this study were to isolate four dimeric flavonoids from Fridericia platyphylla roots and to
evaluate their potential as inhibitors of R. microplus GST.

Results:
In vitro assays confirmed the inhibition of R. microplus GST by BRA-G, BRA-I, BRA-J,
and BRA-K with IC50 values of 0.075, 0.079, 0.075, and 0.058 mg/mL, respectively, with minimal
hemolytic effects. Molecular docking of BRA-G, BRA-I, BRA-J, and BRA-K in a threedimensional
model of R. microplus GST revealed predicted interactions with MolDock Scores of -
142.537, -126.831, -108.571, and -123.041, respectively. Both in silico and in vitro analyses show
that brachydins are potential inhibitors of R. microplus GST.

Conclusion:
The findings of this study deepen our understanding of GST inhibition in ticks, affirming
its viability as a drug target. This knowledge contributes to the advancement of treatment modalities
and strategies for improved tick control.
Bibliometric Analysis of MSC-based Therapies for Non-COVID-19 ARDS
Authors: Huang Shengyu , Wang Dan , Wang Yusong , Ma Qimin , Zhu Zhihao , Liu Xiaobin , Shen Tuo , Wang Xin , Yang Guangping , Ma Shaolin , Guo Guanghua , Zhu Feng 
Published: June 2024

Background:
Acute respiratory distress syndrome (ARDS) poses a significant challenge
as it lacks specific treatments and can occur due to various etiologies. Mesenchymal stem
cells (MSCs) have emerged as a promising cell-based therapy for ARDS due to their immunomodulatory,
anti-inflammatory, and anti-fibrotic properties. Despite encouraging findings from preclinical
studies, clinical evidence supporting the efficacy of MSCs in non-COVID-19 ARDS remains
insufficient.

Methods:
We conducted a systematic search of three major databases (Web of Science Core Collection,
Scopus, and PubMed) to identify original articles focusing on MSCs in non-COVID-19
ARDS. Subsequently, we employed the bibliometric package in R Studio to analyze and visualize
bibliometric indicators derived from the retrieved articles.

Results:
Our analysis of 244 original studies revealed a notable trend in research on MSCs and
non-COVID-19 ARDS. While the number of publications in this area saw an increase beginning
in 2007, it exhibited a decline after 2019, with only 20 articles published in 2022. Notably, a significant
proportion (131/244) of these studies originated from Chinese scholars. MSC derivatives
emerged as a recent research focus due to their unique advantages as an alternative to MSCs. Specifically,
umbilical cord/placental-derived MSCs have gained traction, surpassing the use of bone
marrow-derived MSCs by 2022. The route of delivery is still mainly intravenous. Despite the potential
advantages of the intratracheal route for lung-related diseases, the intravenous route remains
the preferred mode of drug delivery.

Conclusion:
Research on non-COVID-19 ARDS deserves further attention and investments. Existing
studies have primarily focused on MSC derivatives that have shown clinical efficacy. Furthermore,
umbilical cord/placental-derived MSCs are expected to replace traditional bone marrow-
derived MSCs in research. Intratracheal delivery, which offers advantages for treating pulmonary
diseases, still requires extensive experiments to validate.
Correction of Warfarin Coagulopathy for Non-bleeding Patients in the Outpatient Setting at an Ambulatory Care Organization: Application of Vitamin K Guidance
Authors: Khan Aaminah , DeiCicchi David , Collins Peter , Ranade Ashwini , Zaiken Kathy 
Published: June 2024

Background:
Warfarin is an effective anticoagulant but requires close International
Normalized Ratio (INR) monitoring and may occasionally require correction of excessive anticoagulation.
Current guidelines provide limited practical guidance on the administration
of vitamin K for the management of supratherapeutic INR levels ≥ 5.0 in non-bleeding outpatients.

Objective:
Based on expert consensus and guidelines, the Atrius Health Anticoagulation Management
Services (AMS) has developed internal guidance for oral vitamin K use in highly selected
populations. This study will describe the internal guidance for oral vitamin K use and present
associated results and clinical outcomes.

Methods:
Episodes with INR > 5.0 were included, with vitamin K considered for episodes with
INR ≥ 6. Moreover, compelling indications and exclusions to select ideal patients for vitamin K
intervention were also defined.

Results:
Overall, episodes were managed conservatively; of the 246 collected episodes of excessive
anticoagulation, in 18 episodes (7%), patients received vitamin K, and in 228 (93%) episodes,
patients did not receive vitamin K. The mean index INR was 6.0 (range 5.0 – 10.5, SD
1.07), with nearly 57% of episodes achieving INR correction and 15% of episodes developing
INR overcorrection. High thrombotic risk patients, regardless of hemorrhagic risk, were less
likely to receive vitamin K. Three episodes (1.2%) resulted in bleeding complications. No
thrombotic complications occurred during the 30-day follow-up of the index INR value ≥ 5.0.

Conclusion:
Our internal guidance is a novel, standardized approach that serves as a decision
support tool for the management of warfarin-associated coagulopathy and vitamin K intervention
using patient-specific characteristics and index INR values. This guidance may assist other anticoagulation
management services with practical applications and require validation in a prospective
clinical trial.
Synthesis, Antibacterial Activity and In Silico Study of 1-(2-ethyl acetate)-2-styryl 5-nitroimidazole Derivatives
Authors: Aragaw Misgana , Degu Sileshi , Abebe Abiy , Abebayehu Mekonnen , Gebreheiwot Bedane Kibrom , Bisrat Daniel , Tadesse Solomon 
Published: June 2024

Background:
For more than six decades, the use of metronidazole has been limited
to anaerobic microorganisms. However, there are accounts of metronidazole derivatives exhibiting
strong effectiveness against facultative anaerobic bacteria, suggesting that there may
be another mechanism of action for metronidazole. Recent studies have shown that the enzyme
FabH (β-ketoacyl-acyl carrier protein synthase III), responsible for the first step of fatty
acid biosynthesis (FAB), is a promising target for nitroimidazole derivatives that can be used
as an effective anti-infective agent.

Objective:
This study aimed to synthesize 1-(2-ethyl acetate)-2-styryl nitroimidazole derivatives
and evaluate their in vitro and in silico antibacterial activity

Methods:
We synthesized 2-styryl 5-nitroimidazole derivatives by first condensing metronidazole
with benzaldehydes and then carrying out an acetylation reaction. We evaluated the
antimicrobial activity of the synthesized compounds against three Gram-positive bacterial
strains (Staphylococcus aureus, Staphylococcus epidermidis, and Streptococcus agalactiae)
and three Gram-negative bacterial strains (Escherichia coli, Pseudomonas aeruginosa and
Klebsiella pneumoniae) using a two-fold serial dilution MTT (3-(4,5-dimethylthiazol-2-yl)-
2,5-diphenyltetrazolium bromide) assay.

Results:
Compounds 2 and 4 exhibited the highest level of antibacterial effectiveness, with
minimum inhibitory concentrations (MIC) of 1.56 μg/mL against S. agalactiae and 3.13
μg/mL against P. aeruginosa. Compounds 2 and 4 also exhibited potent activity against K.
pneumonia, with an MIC value of 6.25 μg/mL and 12.5 μg/mL, respectively. Molecular docking
studies revealed that both compounds have favorable hydrophobic and electrostatic interactions
with conserved residues in the binding site of the E. coli β-Ketoacyl-acyl carrier protein
synthase III (FabH) complex.

Conclusion::
Acetylation of 2-styryl-5-nitroimidazoles improved both their biological activity
and binding interaction with the target protein
The role of higher education policy in planning information governance at UIN Maulana Malik Ibrahim
Authors: Mudawamah Nita Siti , Fajriyah Annisa , Puspitadewi Ganis Chandra , Pamungkas Firman Jati , Firdaus Aulia Mi'rojtin 
Published: June 2024

Introduction. This study aims to explore the role of higher education policy in planning information governance at the Islamic university, UIN Maulana Malik Ibrahim.
Data Collection Methods. The datacollection technique involved was depth interviews with LPM expert staff, the head of the general division of the faculty, public relations, and an archivist. In addition, to conduct the interviews, reference materials were collected to compile previous studies.
Data Analysis. The data analysis technique encompassed data reduction, data presentation, and conclusion drawing and verification.
Results and Discussion. There is an important role of higher education policy in the process of information management at UIN Maulana Malik Ibrahim. This formulation refers to principles of information governance, which include definition of each party's role, the development of policies and implementation strategies in the governance process, monitoring and auditing of processes and stages of the governance process, information organization processes, and classification. Information, stakeholder participation, and the long-term viability of information governance processes are all important considerations.
Conclusion. Information governance should conducted by the policies established by the relevant educational institution. If the information creation, processing, and governance divisions work properly, locating and acquiring information for institutional reasons should be a breeze.
Author productivity analysis in Q1 of authors in journal library and information science Q1 journals using with Lotka’s Law
Authors: Pratiwi Nasya Meilia , Ibrahim Cecep , Alkarimah Nisya Ula , Arifah Zalika Naila , Jatmik Thufailah Hamida , Mutiara Afini , Azzahra Amelia Fatimah , Putri Sherin Wiryani , Kangko Danang Dwijo , Astarika Rina , Jopang Jopang 
Published: June 2024

Introduction. The purpose of this study is to use Lotka's law to determine the pattern of author output in the field of Library Science in the Library Science Journal Q1 indexed by Scopus.
Data Collection Methods. The quantitative descriptive method was conducted, with a bibliometric approach to explore aspects of scientific articles.
Data Analysis. The research data was acquired from the Scopus International Journal, which can be viewed at www.scopus.com from 2018 to 2022, with article types.
Results and Discussion. The research results found that the number of library science journals indexed by Scopus Q1 was 61. Based on the analysis of Lotka’s law calculations, it is found that the value of C is 0,518 and the value of n was 1,717. The productivity equation for SCOPUS-indexed authors in Library Science journals for 2018–2022 was 0,518, which results in the number of author contributions in publishing one article being 51,84%. In addition, the results of the analysis show that Dmax was 0.280 with a critical value of 0,009.
Conclusion. These findings indicate that Dmax is bigger than the crucial value and it does not follow Lotka's law.
Evaluasi kualitas layanan aplikasi Pustabiblia menggunakan metode digiQUAL
Authors: Suryanto Suryanto , Anggraeni Ervina Desi , Majidah Majidah 
Published: June 2024

Introduction. This research focuses on evaluation of digital library quality services using DigiQUAL method. This research provide evaluation results and knowledge regarding the quality of Pustabiblia application services to support further development.
Data Collection Methods. This is quantitative research with descriptive analysis. Data was taken from a sample of 80 respondents.
Data Analysis. Data analysis techniques used mean and grand mean with Microsoft Excel application to calculate the average service quality variable. The categorization criteria was conducted.
Results and Discussion. The results showed that it was in the high or good category with a service quality index of 3.64. The lowest index in the research was the Resource Use with a value of 3.39.
Conclusion. In general, the quality of the library application service is already in the “good” category but it can still be improved to be in the “very good” category. Further, there needs to be promotion and recommendations regarding the use of the library application so that students can access the library application more often, particularly to meet student information needs.
High Quality Product, Good Services, and Competitive Pricing of Local Coffee Shop to Increase Consumer Satisfaction and Loyalty
Authors: Gunawan Aidin Wahyu , Muhaimin Abdul Wahid , Sitawati Riyanti Isaskar 
Published: June 2024

The objective of this work is to analyze the effect of service quality, product quality and price on the consumer satisfaction and loyalty of “Beli Kopi” at Baureno Village. This research used Structural Equation Modeling (SEM) analysis with a sample of 50 respondents. The results show that most customers were highly educated with high income and women as the main consumers. Service quality, product quality and price have a significant contribution to consumer satisfaction and loyalty. The research model is valid with outer loading > 0.706 and reliable with AVE > 0.874 and improving service quality, product quality and prices in line with consumer values will increase consumer satisfaction and loyalty. It is hoped that this research can provide theoretical and practical contributions in increasing consumer satisfaction and loyalty at “Beli Kopi” Baureno Village. The research also showed that service quality, product and price influence consumer satisfaction. Product quality is the strongest factor. Consumer satisfaction also has a strong influence on loyalty. To increase sales, research suggests that “Beli Kopi” improve service, maintain product quality at appropriate prices, and create attractive promotions. Keywords: Coffee, Price, Product quality, Service quality, SEM (Structural Equation Modeling).
Temporaalisesti, kriittisesti, tunteikkaasti
Authors: Rasi-Heikkinen Päivi 
Published: June 2024

Senioreiden medialukutaitoja koskeva tutkimus on viime vuosina lisääntynyt. Aiempi tutkimus on kuitenkin ongelma- ja vajekeskeistä, eikä se ole riittävästi huomioinut senioreiden taitoja kriittisesti arvioida medioita. Artikkeli vastaa tähän tutkimustiedon tarpeeseen, ja siinä tarkastellaan voimavaranäkökulmasta, kuinka seniorit kuvailevat ja arvioivat medioita ja mediasisältöjä. Tutkimusaineistona on Suomalaisen Kirjallisuuden Seuran kanssa yhteistyössä järjestettyyn kirjoitustapahtumaan osallistuneen 54 seniorin (65–91-vuotiaat) kirjoitukset, jotka sisälsivät sekä kuvauksen yhdestä mediapäivästä että mediasta osana kirjoittajan elämänhistoriaa. Kirjoituksia analysoitiin medialukutaidon jäsennyksiä hyödyntäen sen suhteen, miten niissä arvioitiin medioiden ja mediasisältöjen painottuneisuutta, valikoituneisuutta, näkökulmaisuutta, laatua, luotettavuutta ja henkilökohtaista merkitystä. Tutkimuksen päätulos on, että tutkimukseen osallistuneet seniorit kuvailivat ja arvioivat medioita ja niiden sisältöjä temporaalisesti, kriittisesti ja tunteikkaasti. Tutkimuksen merkittävin uusi tulos on senioreiden medialukutaidon temporaalisuus, jolla tarkoitetaan, että seniorit kuvailivat ja arvioivat nykymedioita ajallisesta näkökulmasta, vertaamalla niitä menneisyyden medioihin ja mediasisältöihin. Temporaalisuuden käsite tekee ymmärrettäväksi sen, miksi esimerkiksi joidenkin nykyisten radio- ja TV-toimittajien puheviestintä näyttäytyy osalle senioreita ”lärpätyksenä”.
”Editoin julkaisua, juttua ja kirjoittajaa”
Authors: Heikkinen Eevi 
Published: June 2024

Tässä analyysissä tarkastellaan journalistista tekstineditointia featurejutun editointiprosessissa. Tavoitteena on kartoittaa jutun rakenteeseen, kieliasuun ja merkityksiin tehtyjä muutoksia ja niiden perusteluja. Analyysin kohteena on helmikuussa 2021 julkaistu Rotuteorioiden suurmaa -juttu.
Analyysi toteutettiin ensin analysoimalla jutusta saatuja tekstiversioita versioita kirjoitus- ja editointiprosessin varrelta hyödyntämällä medialingvistiseen tutkimusperinteeseen kytkeytyvää versioanalyysiä. Siinä tarkasteltiin versioiden välillä tekstissä tapahtuneita korvauksia, lisäyksiä, poistoja ja siirtoja. Näihin havaintoihin haettiin perusteluja editoijan ja toimittajan puolistrukturoiduilla teemahaastatteluilla, joissa sovellettiin stimuloitua mieleenpalauttamista.
Tulokseksi muodostui kronologinen malli editointiprosessin etenemisestä. Tulokset osoittavat, että editointiin vaikuttavat olennaisesti sekä editointiprosessin vaihe että editoijan ja toimittajan välinen vuorovaikutus. Keskeinen johtopäätös on, kuinka käsittelevä editointi koskee erityisesti tiettyjä jutun avainkohtia ja rajausta. Viimeistelevässä editoinnissa keskeistä on tiivistää tekstiä ja tehdä jutusta kielellisesti ja visuaalisesti mahdollisimman miellyttävä. Niin ikään tärkeä johtopäätös koskee sitä, kuinka editointi on erottamattomasti sosiaalista. Editoijan ja toimittajan välinen työskentelysuhde vaikuttaa oleellisesti tekstineditoinnin kohteisiin ja laajuuteen. Editointi kohdistuu paitsi juttuun myös kirjoittajan taitoihin.
Environmental Regulation and Renewable Energies: Evidence from Generalized Panel Unconditional Quantile Regression
Authors: Rahmane Amal , Abdelaoui Okba , Djouadi Issam 
Published: June 2024

Abstract
This study aims to measure the impact of environmental regulation on the production of renewable energies in OECD countries from 1990 to 2021. Environmental policies stringency, environmental taxes, and CO2 emissions are variables indicating environmental regulation, which affect renewable energies production. The study relied on unconditional quantitative regression methods. The study found that strict environmental policies do not necessarily enhance renewable energy production in countries with high or low production. Moreover, environmental tax revenues have varying impacts on renewable energy production based on renewable energy production in each country. For countries with below-average levels of renewable energy (Q25), environmental taxes positively affect renewable energy production; however, in countries with high production levels (Q90), environmental taxes show a negative effect. Furthermore, CO2 emissions negatively affect the total production of renewable energy in all quantiles except Q50, whereas R&D spending positively affects renewable energies in all quantiles except Q75. The estimates also showed a significant negative effect of patents on the renewable energy production in quantile Q10. The results underscore the importance of flexibility and adaptability in environmental policies and taxes. Finally, the study indicates that policies must be dynamic and respond to the specificity of each stage of renewable energy development in the studied countries.
Brain Gym and Core Stability Exercises are Superior in Improving Dynamic Balance in 8-9-Year-Old Children
Authors: Larashati Ni Putu Dwi , Sundari Luh Putu Ratna , Wahyuddin Wahyuddin , Adiputra Luh Made Indah Sri Handari , Iswari Ida , Tianing Ni Wayan , Tianing Ni Wayan 
Published: June 2024

Introduction: The COVID-19 pandemic has led to low physical activity levels among children, resulting in a high risk of falls and injuries. Core stability exercises are standard practices to enhance dynamic balance. Brain Gym and balance boards are alternative activities that can be provided to children to improve dynamic balance. This study aims to demonstrate that combining Brain Gym and core stability exercises is more effective in enhancing dynamic balance in 8-9-year-old children than balance boards and core stability exercises.
Methods: This study employed an experimental design using a Randomized Pre-Test and Post-Test Control Group Design involving 32 participants divided into two groups.
Results: The Wilcoxon signed-rank test revealed a significant difference with a p-value of <0.01 in both Group I and Group II. The difference in means-tested by the Mann-Whitney U-test showed an essential difference between Group I and Group II with a p-value of 0.001 (p <0.05).
Conclusion: Brain Gym and core stability exercises are superior in improving dynamic balance in 8-9-year-old children compared to balance boards and core stability exercises.

Keywords: Brain Gym, balance board, core stability exercise, dynamic balance