bluuebunny/crossref_metadata_2025_split huggingface dataset:
Closed‐loop performance metrics for fault detection and isolation filter and controller interaction
Authors: Pandita Rohit , Bokor József , Balas Gary 
Published: December 2011

SUMMARYFault detection and isolation (FDI) filters are typically synthesized for open‐loop or closed‐loop systems. The controller affects the FDI filter performance in the closed‐loop system. FDI filter performance and closed‐loop controller–filter interaction in the presence of uncertain dynamics were investigated as was the role of controller robustness on the FDI filter performance. The NASA Generic Transport Model aircraft was considered as a motivating application. Multiple example scenarios were presented to highlight the utility of FDI filter performance metrics. For example, comparing fault detection performance of different filters under identical uncertain plant dynamics and controller, the effect of different controllers on the FDI filter performance, and the effect of model uncertainty on filter performance. The Generic Transport Model aircraft FDI filter results are validated using worst‐case analysis and linear simulations. Copyright © 2011 John Wiley & Sons, Ltd.
Variation in breeding parameters of Eleonora's falcon (Falco eleonorae) and factors affecting its reproductive performance
Authors: Xirouchakis S. M. , Fric J. , Kassara C. , Portolou D. , Dimalexis A. , Karris G. , Barboutis C. , Latsoudis P. , Bourdakis S. , Kakalis E. , Sfenthourakis S. 
Published: December 2011

AbstractWe gathered data for a four‐year period (2004–2007) on the nesting ecology and reproductive performance of Eleonora's falcon in the Aegean Sea. We investigated in an indirect way the relation between clutch size and pre‐laying food availability, the significance of site and pair quality on productivity, and the effects of habitat and intraspecific competition on breeding success. Overall, the species selected nest sites sheltered from sun exposure but not from the prevailing wind. Hatching, fledging, and breeding success rates were estimated at 64, 72%, and 60%, respectively. Fledglings per breeding pair ranged from 1.19 to 1.75, and fledglings per successful pair from 1.84 to 2.0, between the years. Productivity depended on parental care rather than nest‐site quality. Breeding parameters varied significantly between the years, exhibiting a strong spatial yet local effect. Low success rates were recorded in specific colonies, which were attributed to adverse weather conditions and habitat degradation. Insect food availability prior to egg‐laying, estimated via plant biomass, was positively correlated to clutch size. Meanwhile, low wind strengths in August, large distances from the mainland, and population size in the vicinity of the colonies had negative effects on breeding success. Considering data at the Mediterranean scale, a longitudinal trend is observed across the breeding range of this species, with breeding parameters slightly decreasing from west to east.
Branch and bound algorithms for the maximum clique problem under a unified framework
Authors: Carmo Renato , Züge Alexandre 
Published: December 2011

Abstract
In this paper we review branch and bound-based algorithms proposed for the exact solution of the maximum clique problem and describe them under a unifying conceptual framework. As a proof of concept, we actually implemented eight of these algorithms as parametrized versions of one single general branch and bound algorithm.
The purpose of the present work is double folded. In the one hand, the implementation of several different algorithms under the same computational environment allows for a more precise assessment of their comparative performance at the experimental level. On the other hand we see the unifying conceptual framework provided by such description as a valuable step toward a more fine grained analysis of these algorithms.
Sentiment-based influence detection on Twitter
Authors: Bigonha Carolina , Cardoso Thiago N. C. , Moro Mirella M. , Gonçalves Marcos A. , Almeida Virgílio A. F. 
Published: December 2011

Abstract
The user generated content available in online communities is easy to create and consume. Lately, it also became strategically important to companies interested in obtaining population feedback on products, merchandising, etc. One of the most important online communities is Twitter: recent statistics report 65 million new tweets each day. However, processing this amount of data is very costly and a big portion of the content is simply not useful for strategic analysis. Thus, in order to filter the data to be analyzed, we propose a new method for ranking the most influential users in Twitter. Our approach is based on a combination of the user position in networks that emerge from Twitter relations, the polarity of her opinions and the textual quality of her tweets. Our experimental evaluation shows that our approach can successfully identify some of the most influential users and that interactions between users provide the best evidence to determine user influence.
Mental health promotion: Guidance and strategies
Authors: Kalra G. , Christodoulou G. , Jenkins R. , Tsipas V. , Christodoulou N. , Lecic-Tosevski D. , Mezzich J. , Bhugra D. 
Published: December 2011

AbstractPublic mental health incorporates a number of strategies from mental well-being promotion to primary prevention and other forms of prevention. There is considerable evidence in the literature to suggest that early interventions and public education can work well for reducing psychiatric morbidity and resulting burden of disease. Educational strategies need to focus on individual, societal and environmental aspects. Targeted interventions at individuals will also need to focus on the whole population. A nested approach with the individual at the heart of it surrounded by family surrounded by society at large is the most suitable way to approach this. This Guidance should be read along with the European Psychiatric Association (EPA) Guidance on Prevention. Those at risk of developing psychiatric disorders also require adequate interventions as well as those who may have already developed illness. However, on the model of triage, mental health and well-being promotion need to be prioritized to ensure that, with the limited resources available, these activities do not get forgotten. One possibility is to have separate programmes for addressing concerns of a particular population group, another that is relevant for the broader general population. Mental health promotion as a concept is important and this will allow prevention of some psychiatric disorders and, by improving coping strategies, is likely to reduce the burden and stress induced by mental illness.
Availability and quality of emergency obstetric and neonatal care services in Afghanistan
Authors: Kim Young‐Mi , Zainullah Partamin , Mungia Jaime , Tappis Hannah , Bartlett Linda , Zaka Nabila 
Published: December 2011

AbstractObjectiveTo assess the availability and utilization of emergency obstetric and neonatal care (EmONC) facilities in Afghanistan, as defined by UN indicators.MethodsIn a cross‐sectional study of 78 first‐line referral facilities located in secure areas of Afghanistan, EmONC service delivery was evaluated by using Averting Maternal Deaths and Disabilities (AMDD) Program assessment tools.ResultsForty‐two percent of peripheral facilities did not perform all 9 signal functions required of comprehensive EmONC facilities. The study facilities delivered 17% of all neonates expected in their target populations and treated 20% of women expected to experience direct complications. The population‐based rate of cesarean delivery was 1%. Most maternal deaths (96%) were due to direct causes. The direct and indirect obstetric case fatality rates were 0.8% and 0.2%, respectively.ConclusionNotable progress has been made in Afghanistan over the past 8 years in improving the quality, coverage, and utilization of EmONC services, but gaps remain. Re‐examination of the criteria for selecting and positioning EmONC facilities is recommended, as is the provision of high‐quality, essential maternal and neonatal health services at all levels of the healthcare system, linked by appropriate communication and functional referral systems.
Bacterial Phosphoproteomic Analysis Reveals the Correlation Between Protein Phosphorylation and Bacterial Pathogenicity
Authors: Ge Ruiguang , Shan Weiran 
Published: December 2011

Abstract
Increasing evidence shows that protein phosphorylation on serine, threonine and tyrosine residues is a major regulatory post-translational modification in the bacteria. This review focuses on the implications of bacterial phosphoproteome in bacterial pathogenicity and highlights recent development of methods in phosphoproteomics and the connectivity of the phosphorylation networks. Recent technical developments in the high accuracy mass spectrometry have dramatically transformed proteomics and made it possible the characterization of a few exhaustive site-specific bacterial phosphoproteomes. The high abundance of tyrosine phosphorylations in a few bacterial phosphoproteomes suggests their roles in the pathogenicity, especially in the case of pathogen–host interactions; the high abundance of multi-phosphorylation sites in bacterial phosphoprotein is a compensation of the relatively small phosphorylation size and an indicator of the delicate regulation of protein functions.
Cloning, Expression, and Homology Modeling of GroEL Protein from Leptospira Interrogans Serovar Autumnalis Strain N2
Authors: Natarajaseenivasan Kalimuthusamy , Shanmughapriya Santhanam , Velineni Sridhar , Artiushin Sergey C. , Timoney John F. 
Published: December 2011

Abstract
Leptospirosis is an infectious bacterial disease caused by Leptospira species. In this study, we cloned and sequenced the gene encoding the immunodominant protein GroEL from L. interrogans serovar Autumnalis strain N2, which was isolated from the urine of a patient during an outbreak of leptospirosis in Chennai, India. This groEL gene encodes a protein of 60 kDa with a high degree of homology (99% similarity) to those of other leptospiral serovars. Recombinant GroEL was overexpressed in Escherichia coli. Immunoblot analysis indicated that the sera from confirmed leptospirosis patients showed strong reactivity with the recombinant GroEL while no reactivity was observed with the sera from seronegative control patient. In addition, the 3D structure of GroEL was constructed using chaperonin complex cpn60 from Thermus thermophilus as template and validated. The results indicated a Z-score of −8.35, which is in good agreement with the expected value for a protein. The superposition of the Cα traces of cpn60 structure and predicted structure of leptospiral GroEL indicates good agreement of secondary structure elements with an RMSD value of 1.5 Å. Further study is necessary to evaluate GroEL for serological diagnosis of leptospirosis and for its potential as a vaccine component.
Forecasting F10.7 with solar magnetic flux transport modeling
Authors: Henney C. J. , Toussaint W. A. , White S. M. , Arge C. N. 
Published: December 2011

A new method is presented here to forecast the solar 10.7 cm (2.8 GHz) radio flux, abbreviated F10.7, utilizing advanced predictions of the global solar magnetic field generated by a flux transport model. Using indices derived from the absolute value of the solar magnetic field, we find good correlation between the observed photospheric magnetic activity and the observed F10.7 values. Comparing magnetogram data observed within 6 hours of the F10.7 measurements during the years 1993 through 2010, the Spearman correlation coefficient, rs, for an empirical model of F10.7 is found to be 0.98. In addition, we find little change in the empirical model coefficients and correlations between the first and second 9 year intervals of the 18 year period investigated. By evolving solar magnetic synoptic maps forward 1–7 days, this new method provides a realistic estimation of the Earth‐side solar magnetic field distribution used to forecast F10.7. Spearman correlation values of approximately 0.97, 0.95, and 0.93 are found for 1 day, 3 day, and 7 day forecasts, respectively. The method presented here can be expanded to forecast other space weather parameters, e.g., total solar irradiance and extreme ultraviolet flux. In addition, near‐term improvements to the F10.7 forecasting method, e.g., including far‐side magnetic data with solar magnetic flux transport, are discussed.
Time Trends for Livestock Production in Saskatchewan, Canada: 1905-2011
Authors: Rayne Sierra , Forest Kaya 
Published: December 2011

AbstractSaskatchewan, Canada, with a total land area of 651,900 km^2^, is one of the world’s most productive agricultural regions. A broad variety of livestock are raised in the province, including cattle, pigs, poultry, sheep/goats, llama, ostrich, elk, deer, and bison. In 2010, the total revenue from the Saskatchewan livestock sector was CAD$1.6 billion. Over the past century, changing industry economics and advances in scientific, technical, and engineering knowledge and practices have affected the amount and type of livestock produced. The current work examines time trends for livestock production since Saskatchewan was created in 1905. While production trends vary widely by livestock type, most sectors display clearly increasing amounts of industry consolidation over time, warranting more detailed investigations into the socio-economical and technological drivers behind such changes.
Episodic Long-Term Memory of Spoken Discourse Masked by Speech: What Is the Role for Working Memory Capacity?
Authors: Sörqvist Patrik , Rönnberg Jerker 
Published: December 2011

Purpose
To investigate whether working memory capacity (WMC) modulates the effects of to-be-ignored speech on the memory of materials conveyed by to-be-attended speech.

Method
Two tasks (reading span, Daneman & Carpenter, 1980; Rönnberg et al., 2008; and size-comparison span, Sörqvist, Ljungberg, & Ljung, 2010) were used to measure individual differences in WMC. Episodic long-term memory of spoken discourse was measured by requesting participants to listen to stories masked either by normal speech or by a rotated version of that speech and to subsequently answer questions on the content of the stories.

Results
Normal speech impaired performance on the episodic long-term memory test, and both WMC tasks were negatively related to this effect, indicating that individuals with high WMC are less susceptible to disruption. Moreover, further analyses revealed that size-comparison span (a task that requires resolution of semantic confusion by inhibition processes) is a stronger predictor of the effect than is reading span.

Conclusions
Cognitive control processes support listening in adverse conditions. In particular, inhibition processes acting to resolve semantic confusion seem to underlie the relationship between WMC and susceptibility to distraction from masking speech.
Predictors of dose escalation of adalimumab in a prospective cohort of Crohn’s disease patients
Authors: Bultman E. , de Haar C. , van Liere‐Baron A. , Verhoog H. , West R. L. , Kuipers E. J. , Zelinkova Z. , Janneke van der Woude C. 
Published: December 2011

SummaryBackground  Adalimumab is effective for the induction and maintenance of remission in Crohn’s disease (CD)‐patients.Aim  To find predictors for adalimumab dose escalation at initiation of adalimumab.Methods  Crohn’s disease patients in a single tertiary referral centre who started adalimumab between July 2007 and March 2010 at an induction dose (week 0 160 mg subcutaneously (sc), week 2 80 mg sc) and maintenance dose of 40 mg sc thereafter every other week were followed prospectively. Patients on adalimumab for at least 3 months were included. The number of patients needing dose escalation was assessed. Patients that needed dose escalation were compared with patients that did not need dose escalation.Results  Of 199 CD patients treated with adalimumab and followed prospectively, 122 patients (M/F 54/68, median age 35 years, range 18–66 years, median CDAI 164, range 6–468) were treated for 3 months. In total 38% of these patients (46/122) needed a dose escalation within a median time of 21 weeks after adalimumab introduction (range 4–105). Body mass index (BMI) (P < 0.03) and secondary non‐response to infliximab (IFX) (P < 0.06) were identified as predictors for dose escalation. Concomitant use of immunomodulators at initiation of adalimumab and the presence of autoantibodies to IFX did not predict dose escalation.Conclusions  Over one‐third adalimumab‐treated patients are dose escalated within a median of 5 months. Higher BMI and secondary non‐response to IFX treatment are predictive for a dose escalation during adalimumab treatment.
The pan‐histone deacetylase inhibitor CR2408 disrupts cell cycle progression, diminishes proliferation and causes apoptosis in multiple myeloma cells
Authors: Baumann Philipp , Junghanns Carmen , Mandl‐Weber Sonja , Strobl Stefan , Oduncu Fuat , Schmidmaier Ralf 
Published: December 2011

SummaryIn view of the fact that histone deacetylases (HDACs) are promising targets for myeloma therapy, we investigated the effects of the HDAC inhibitor CR2408 on multiple myeloma (MM) cells in vitro. CR2408 is a direct pan‐HDAC inhibitor and inhibits all known 11 HDACs with a 50% inhibitory concentration (IC50) of 12 nmol/l (HDAC 6) to 520 nmol/l (HDAC 8). Correspondingly, CR2408 induces hyperacetylation of histone H4, inhibits cell growth and strongly induces apoptosis (IC50 = 0·1–0·5 μmol/l) in MM cell lines and primary MM cells. CR2408 leads to fragmentation of cells and induces an accumulation in the subG1 phase accompanied with moderately decreased levels of cyclin D1 and cdk4 and strongly decreased levels of cdc25a, pRb and p53. Interruption of the cell cycle is reflected by inhibition of cell proliferation and is accompanied by decreased phosphorylation of 4E‐BP1 and p70S6k. Treatment with CR2408 results in increased protein levels of Bim and pJNK and downregulation of Bad and Bcl‐xL and activation of Caspases 3, 8 and 9. Furthermore, as HDAC inhibitors have shown synergism with other drugs, these effects were investigated and synergism was observed for combinations of CR2408 with doxorubicin and bortezomib. In conclusion, we have identified potent anti‐myeloma activity for this novel HDAC inhibitor that gives further insights into the biological sequelae of HDAC inhibition in MM.
Nano‐indentation testing of new and fractured nickel‐titanium endodontic instruments
Authors: Jamleh A. , Sadr A. , Nomura N. , Yahata Y. , Ebihara A. , Hanawa T. , Tagami J. , Suda H. 
Published: December 2011

Jamleh A, Sadr A, Nomura N, Yahata Y, Ebihara A, Hanawa T, Tagami J, Suda H. Nano‐indentation testing of new and fractured nickel‐titanium endodontic instruments. International Endodontic Journal, 45, 462–468, 2012.AbstractAim  To investigate the effect of cyclic fatigue on nickel‐titanium (NiTi) endodontic instruments using a nano‐indentation test.Methodology  Eight ProFile NiTi rotary instruments (size 30, taper 0.06; Dentsply Maillefer, Ballaigues, Switzerland) were tested using a cyclic fatigue set‐up until fracture. The fractured instruments and eight new NiTi instruments of the same size and taper were used for a nano‐indentation test on the internal surfaces of a NiTi instruments in the region just adjacent to their fractured edge (group I) and in the same region of the new group (group II), and the cutting part beside the shaft for both instruments [group III (fractured) and group IV (new)]. Data were statistically analyzed using one‐way analysis of variance and Games–Howell post hoc test. The alpha‐type error was set at 0.05.Results  Significant differences in terms of hardness and elastic modulus for each group (P < 0.05) were found, with group I having the lowest mean values followed by group III. Additionally, standard deviations increased remarkably after failure, as represented by groups I and III.Conclusion  The nano‐indentation technique can be applied to determine the performance and the failure mechanism of NiTi instruments. The fatigue process revealed a significant decrease in the hardness and elastic modulus of the NiTi instrument. As indicated by the low hardness, the fatigue process did not result in work hardening but rather work softening.
An exploratory study investigating the impact of the procedures used to manage patient substance misuse on nurse–patient relationships in a medium secure forensic unit
Authors: PRICE O. , WIBBERLEY C. 
Published: December 2011

Accessible summary
This study investigated the perspectives of mental health nurses working in a medium secure unit, regarding the impact of the security procedures used to manage patient substance misuse on nurse–patient relationships.
Data from the interviews were analysed and revealed that the participants perceived that the intrusive nature of the procedures was detrimental to their relationship with patients. Both the relative degree of intrusion posed by the procedure, and the communication skills of nurses were important factors in determining the extent and duration of negative effects on relationships.
A number of recommendations were made to improve policy and practice in relation to the application of the procedures. Firstly, that the use of partial strip searching should be minimized. Secondly, that unit managers should ensure consistent application of urine drug screening policies and that responsibility for undertaking the procedures should be spread evenly throughout nursing teams to avoid patients ‘splitting’ teams into ‘good’ and ‘bad’ nurses; Finally, that staff should receive further training in both substance misuse and communication skills.
AbstractThe role conflict experienced by forensic psychiatric nurses between their therapeutic responsibilities and their responsibility to operationalize security procedures is well established in the literature. There has been less investigation into how this role conflict is played out specifically in the management of inpatient substance misuse in forensic units. This study, therefore, aimed to explore the views of nurses working in one medium secure unit of the impact of the procedures used to manage substance misuse (partial strip searching, room searching, canine searching, ‘pat’ (or ‘rubdown’) searching, urine drug screening) on their relationships with patients. Ten interviews of registered mental health nurses working in a medium secure unit in the Northwest were carried out. The interview data were transcribed verbatim and framework analysis used to identify emergent themes. The impact of the procedures on nurse–patient relationships was reported as largely negative by the participants. They reported that the intrusion of the procedures had a detrimental effect on their relationships with patients. The relative degree of intrusion posed by each of the procedures was an important factor in determining the extent and duration of damage to nurse–patient relationships, as was the communication skills of the nurse conducting the procedure.