bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combined lineage tracing and scRNA‐seq reveal the activation of Sox9+ cells in renal regeneration with PGE2 treatment
Authors: Chen Shang , Liu Yue , Chen Xiaoniao , Tao Hongyan , Piao Yongjun , Huang Haoyan , Han Zhibo , Han Zhong‐Chao , Chen Xiang‐Mei , Li Zongjin 
Published: May 2024

AbstractUncovering mechanisms of endogenous regeneration and repair through resident stem cell activation will allow us to develop specific therapies for injuries and diseases by targeting resident stem cell lineages. Sox9+ stem cells have been reported to play an essential role in acute kidney injury (AKI). However, a complete view of the Sox9+ lineage was not well investigated to accurately elucidate the functional end state and the choice of cell fate during tissue repair after AKI. To identify the mechanisms of fate determination of Sox9+ stem cells, we set up an AKI model with prostaglandin E2 (PGE2) treatment in a Sox9 lineage tracing mouse model. Single‐cell RNA sequencing (scRNA‐seq) was performed to analyse the transcriptomic profile of the Sox9+ lineage. Our results revealed that PGE2 could activate renal Sox9+ cells and promote the differentiation of Sox9+ cells into renal proximal tubular epithelial cells and inhibit the development of fibrosis. Furthermore, single‐cell transcriptome analysis demonstrated that PGE2 could regulate the restoration of lipid metabolism homeostasis in proximal tubular epithelial cells by participating in communication with different cell types. Our results highlight the prospects for the activation of endogenous renal Sox9+ stem cells with PGE2 for the regenerative therapy of AKI.
Current status and future perspectives of robotic liver surgery
Authors: Soyama Akihiko , Hamada Takashi , Adachi Tomohiko , Eguchi Susumu 
Published: May 2024

AbstractRobotic liver resection has been reported in case series since the early 2000s. The surgical robot is capable of precise operation using articulated forceps with seven degrees of freedom. The robot also eliminates tremors and provides a good surgical field with highly detailed 3D high‐definition images. The clinical results demonstrating their usefulness have been increasing year by year. Initially, a shorter hospital stay was observed in comparison with open hepatectomy. Recent reports have also shown lower conversion and complication rates in comparison with laparoscopic hepatectomy. The clamp and crush method with bipolar forceps, sealing devices, ultrasonic shears, and the combined procedure of Cavitron ultrasonic surgical aspirator and robotic forceps as hybrid procedures have been reported as effective methods of parenchymal transection in robotic surgery. Theoretically, the advantages of the robotic platform allow for more complex liver resection around hilar structures and major blood vessels, as well as for vascular reconstruction or biliary reconstruction. The application of robotic liver surgery for hilar cholangiocarcinoma, living donor hepatectomy, and living donor liver transplantation has been reported. Robotic liver surgery is becoming more popular for certain indications; however, it is important to further evaluate its long‐term surgical and oncological outcomes and costs in comparison with conventional laparoscopic and open liver surgery, based on accumulated experience.
Ulcerated nodules with zosteriform distribution on the upper extremity
Authors: Wang Fan , Wei Zhen‐Dong 
Published: May 2024

AbstractEccrine porocarcinoma (EPC) is a rare skin adnexal malignancy with a high potential for metastases. The most common metastatic sites are the lymph nodes and lungs. CCutaneous metastasis is extremely rare, particularly the zosteriform variant, with fewer than 5 cases reported in the literature. Here, we report a unique case of EPC in a 71‐year‐old male, clinically presenting with multiple clusters of ulcerated nodules distributing as a zosteriform pattern throughout his upper left limb, along with draining lymphatic metastases and lymphedema.
Exploring pharmacological treatment for trichotillomania: do we need better education?
Authors: Krajewski Piotr K. , Zirpel Henner , Saceda‐Corralo David , Thaçi Diamant , Szepietowski Jacek C. 
Published: May 2024

AbstractBackgroundTrichotillomania, also known as hair‐pulling disorder, is a chronic psychiatric condition with a fluctuating course in which an individual pulls out their hair, leading to visible hair loss and psychosocial sequelae. Due to the unknown pathogenesis, the treatment of this disorder is complex and remains a challenge for dermatologists and psychiatrists. Since guidelines for treating trichotillomania are lacking and, consequently, no common treatment strategy exists, we decided to perform a large‐scale, global retrospective cohort study to assess the characterized real‐world prescription patterns in treating trichotillomania.MethodsThe research used the TrinetX database for patients with trichotillomania (ICD 10 – F63.3) within the European and the United States Collaborative Network (EC and UC, respectively). After consulting with a psychodermatology expert, a list of 25 medications was investigated.ResultsData on the prescription drugs of 1,275 patients from the EC and 109,741 patients from the UC were collected. In both the EC and UC cohorts, benzodiazepine derivatives, particularly lorazepam and midazolam, were the most commonly prescribed sedatives/hypnotics. Antipsychotic prescriptions, primarily haloperidol, followed benzodiazepines. After the trichotillomania diagnosis, notable changes in drug prescriptions for the EC cohort, including an increased likelihood of receiving acetylcysteine, haloperidol, quetiapine, sertraline, olanzapine, and risperidone were observed. The UC cohort showed minimal changes. Overall, both cohorts leaned toward benzodiazepine prescriptions (37% UC, 21% EC) and had limited antidepressant usage. Haloperidol (19.3%) and quetiapine (15.1%) were commonly prescribed in both cohorts.ConclusionsThe results of our study indicate that the real‐world prescription patterns for trichotillomania differ significantly from the expert‐proposed therapeutic approach and point toward the necessity of creating standards of pharmacological care and better education.
Soy protein isolate with higher solubility and improved gel properties when co‐assembled with walnut protein
Authors: Li Junyou , Chen Yunqi , Hua Xiaohan , Yin Lijun , Zang Jiachen , Yu Wenhua , Zhang Tuo 
Published: May 2024

SummaryPhytoproteins have been widely implemented in the food industry benefiting from their good functionalities, vast reserves and relatively low cost. However, phytoproteins frequently experience poor solubility, which limits their applications. In our study, the solubility of soy protein isolate (SPI) treated with pH‐shifting increased over 1.8 times; however, the transglutaminase‐induced gel properties were sacrificed. To solve this problem, walnut protein (WP) was used to co‐assemble with SPI during the treatment. The co‐assembly hybrid protein shows significantly better solubility, meanwhile, maintaining the transglutaminase‐induced gel properties and improving the cohesiveness and resilience properties compared with untreated SPI, which behaved an improved water holding capacity during storage. The detailed mechanisms were investigated with rheological analysis, SEM, textural analysis and Fourier transform infrared spectroscopy (FTIR). Overall, our study provided a promising strategy to develop SPI/WP hybrid composites with high solubility and improved gel properties to extend the application of SPI in the food industry.
Climate change, tax avoidance, and shareholder value: Evidence from the Paris Agreement
Authors: Chatjuthamard Pattanaporn , Chintrakarn Pandej , Jiraporn Pornsit , Lee Sang Mook 
Published: May 2024

AbstractMotivated by the rapidly emerging literature on climate change and finance, we explore the effect of corporate tax avoidance on shareholder value around the adoption of the Paris Climate Agreement. Companies engaging in greater tax avoidance experience significantly more favorable stock market reactions. Companies that achieve greater savings through tax avoidance have a larger surplus of resources that can be directed toward climate‐related actions in alignment with the Paris Agreement, resulting in enhanced shareholder value. Furthermore, the advantageous impact of tax avoidance on shareholder wealth is significantly less pronounced for companies that pay out larger dividends.
Effect of the cycle number of multistep sintering on the properties of FeSe0.4Te0.6 superconductors
Authors: Miao Chaohang , Liu Linfei , Li Yijie 
Published: May 2024

AbstractFeSe0.4Te0.6 polycrystal bulks were synthesized using the solid‐state sintering method. We developed a novel multistep sintering process and studied the impact of the sintering cycle number. Different cycles of multistep sintering, ranging from one to four cycles were systematically arranged. It was found that the superconducting properties of the FeSe0.4Te0.6 polycrystal bulk using three cycles of sintering surpassed those of other samples, reaching a maximum of = 13.4 K, = 14.7 K, and a minimum of ∆ = 1.3 K. And the superconducting current density at 4 K reached 1.77 × 104 A/cm2, exhibiting a weak fishtail effect. At 9 K, a composite pinning effect emerged, consisting of normal point pinning and ∆κ surface pinning. The enhancement in superconductivity is attributed to improve uniformity in grain arrangement and more effective element diffusion. After multiple sintering cycles, the stacked grains exhibited increased thickness and the grain arrangement became dense.
Measurement of medical students' knowledge, attitude and practice towards antibiotic use and resistance: A scoping review
Authors: Sun Hui , Gao Yinyan , Liu Wenqi , Zhang Jiajia , Wu Irene Xy 
Published: May 2024

AbstractObjectiveMedical students are demanders and future suppliers of antibiotic use. Understanding their knowledge, attitude and practice is important for appropriately using antibiotics and controlling antibiotic resistance. The objective of this study was to assess the measurement properties of existed instruments and summarize measurement items and results.MethodsFive English and Chinese databases were searched to comprehensively identify related studies between January 2000 and May 2023. Included instruments were assessed using consensus‐based standards for the selection of health measurement instruments checklist. Descriptive tables and narrative texts were applied to summary the data.ResultsOf 3524 studies identified, 25 were finally included, from which 22 measurement instruments were included. Of these, 14 instruments were found with adequate content validity, only one study reported structural validation process and two studies reported reliability test results. Similar items were divided into different dimensions in different studies. Gaps and misconceptions in knowledge and attitude were indicated in antibiotic use principles, including antibiotic use indications and selection.ConclusionsLimitations existed in the current measurement instrument including lacking validation, inconsistent classification of item and lacking item regarding the perspective of suppliers. Scientific tools for objective and accurate measure are needed.
Metabolic organization of pregnant freshwater stingray and their offspring
Authors: da Silva Natalia Carvalho Fabricio , de Sousa Rangel Bianca , dos Santos Zacheo Évillyn , de Castro Ribeiro Douglas , da Silva Ribeiro Cristiéle 
Published: May 2024

AbstractThe elucidation of energetic patterns in adult viviparous elasmobranchs and their offspring can contribute to understanding ecophysiological questions, such as maternal‐fetal metabolism and group life‐history traits. We characterized the energetic substrates in pregnant individuals and stages of offspring development in the freshwater stingray Potamotrygon amandae. Our results show that the energetic distribution of the yolk is composed of more lipids than proteins, whereas the inverse pattern is observed in the egg and uterus, proving the plasticity of the energy provision of the species. As a novelty, we describe that yolk/intestine transfer occurs in this species.
Immune signature and therapeutic approach of natural killer cell in chronic liver disease and hepatocellular carcinoma
Authors: Shin Seung Kak , Oh Sooyeon , Chun Su‐Kyung , Ahn Min‐Ji , Lee Seung‐Min , Kim Kayun , Kang Hogyeong , Lee Jeongwoo , Shin Suk Pyo , Lee Jooho , Jung Young Kul 
Published: May 2024

AbstractNatural killer (NK) cells are one of the key members of innate immunity that predominantly reside in the liver, potentiating immune responses against viral infections or malignant tumors. It has been reported that changes in cell numbers and function of NK cells are associated with the development and progression of chronic liver diseases (CLDs) including non‐alcoholic fatty liver disease, alcoholic liver disease, and chronic viral hepatitis. Also, it is known that the crosstalk between NK cells and hepatic stellate cells plays an important role in liver fibrosis and cirrhosis. In particular, the impaired functions of NK cells observed in CLDs consequently contribute to occurrence and progression of hepatocellular carcinoma (HCC). Chronic infections by hepatitis B or C viruses counteract the anti‐tumor immunity of the host by producing the sheddases. Soluble major histocompatibility complex class I polypeptide‐related sequence A (sMICA), released from the cell surfaces by sheddases, disrupts the interaction and affects the function of NK cells. Recently, the MICA/B‐NK stimulatory receptor NK group 2 member D (NKG2D) axis has been extensively studied in HCC. HCC patients with low membrane‐bound MICA or high sMICA concentration have been associated with poor prognosis. Therefore, reversing the sMICA‐mediated downregulation of NKG2D has been proposed as an attractive strategy to enhance both innate and adaptive immune responses against HCC. This review aims to summarize recent studies on NK cell immune signatures and its roles in CLD and hepatocellular carcinogenesis and discusses the therapeutic approaches of MICA/B‐NKG2D‐based or NK cell‐based immunotherapy for HCC.
Relationship between social support and self‐care ability among patients with breast cancer during rehabilitation: The multiple mediating roles of resilience and depression
Authors: Tang Xiu‐Ying , Wei Yu‐Xian , Kong Ling‐Na , Lu Fang 
Published: May 2024

AbstractAimsTo identify the multiple mediating effects of resilience and depression between social support and self‐care ability among patients with breast cancer during rehabilitation to provide reference for developing and implementing targeted interventions.DesignA cross‐sectional study reported according to the STROBE checklist.MethodsA convenience sample of 320 patients with breast cancer during rehabilitation was recruited from one hospital in China. Data were collected from April to August 2022 using a self‐report questionnaire, including the demographic and clinical information, Appraisal of Self‐Care Agency Scale‐Revised, Multidimensional Scale of Perceived Social Support, Connor‐Davidson Resilience Scale‐10 item, and Patient Health Questionnaire‐9. The mediation analysis was conducted using the SPSS Process macro.ResultsSelf‐care ability was positively associated with social support (β = .229) and resilience (β = .290), and negatively associated with depression (β = −.208). The relationship between social support and self‐care ability was mediated by resilience and depression, respectively, and together in serial. The multiple mediating effects accounted for 34.0% of the total effect of social support on self‐care ability.ConclusionOur findings identify resilience and depression as multiple mediators between social support and self‐care ability and highlight the important roles of social support, resilience and depression in improving self‐care ability.Relevance to Clinical PracticeHealthcare providers should pay great attention to the underlying mechanisms of how social support affects patients' self‐care ability during breast cancer rehabilitation. Integrated intervention programmes targeted at enhancing social support, building resilience and alleviating depression might be beneficial to the improvement of self‐care ability.Patient or Public ContributionNo patient or public contribution.Reporting MethodThe Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) checklist for cross‐sectional studies was applied to report the results.
Measurement properties of patient‐reported outcome measures for women with dysmenorrhea: A systematic review
Authors: de Arruda Guilherme Tavares , Driusso Patricia , de Godoy Amanda Garcia , de Sousa Ana Paula , Avila Mariana Arias 
Published: May 2024

AbstractBackgroundDysmenorrhea, or menstrual pain, is a subjective experience, and can only be assessed by patient‐reported outcomes. These instruments should be reliable, valid and responsive.AimTo identify and critically appraise the available evidence for the measurement properties of specific patient‐reported outcome measures used for dysmenorrhea.MethodsThe PRISMA statement was used to report this systematic review. Databases searched were PubMed, SCOPUS, CINAHL, Web of Science, ScienceDirect and Google Scholar (April 2021; updated on February 2023). Original studies with primary data collection, with no restriction on language and publication date that reported psychometric properties of one or more dysmenorrhea‐related patient‐reported outcome measure. The literature searches, selection of studies, data extraction and assessment of the risk of bias were performed independently by two reviewers and followed the COSMIN guidelines.ResultsThirty studies were analysed in this review, and 19 patient‐reported outcome measures were evaluated. The instruments varied in relation to the measured construct and measurement properties (validity, reliability and responsiveness). The methodological quality of the studies and the quality of evidence of the patient‐reported outcome measures were variable. Among the 13 studies that reported the development of patient‐reported outcome measures, most had inadequate methodological quality, and the overall rating was insufficient or inconsistent.ConclusionsThe Dysmenorrhea Symptom Interference (DSI) scale was the only identified patient‐reported outcome measure that has the potential to be recommended because of its sufficient rating combined with moderate quality of evidence for content validity. Future studies should further evaluate the measurement properties of the existing patient‐reported outcome measures, or develop new patient‐reported outcome measures following the COSMIN methodology.Patient or public contributionNot applicable as this is a systematic review.Trial registrationPROSPERO protocol: CRD42021244410. Registration on April 22, 2021.
Referred pain is associated with greater odontogenic spontaneous pain and a heightened pain sensitivity in patients with symptomatic irreversible pulpitis
Authors: de Souza Paulo Roberto Jara , Ardestani Soraya Salmanzadeh , Costa Vanessa Abreu Sanches Marques , Alcalde Murilo Priori , Hungaro Duarte Marco Antônio , Vivan Rodrigo Ricci , Conti Paulo César Rodrigues , Costa Yuri Martins , Bonjardim Leonardo Rigoldi 
Published: May 2024

AbstractBackgroundSymptomatic irreversible pulpitis often results in heightened reactions to thermal stimuli such as pain evoked by a cold stimulus, and spontaneous odontogenic pain (unprovoked pain).ObjectiveThis study primarily compared the clinical manifestations of odontogenic spontaneous pain and pain provoked by cold stimulus specifically focusing on their sensory discriminative characteristics (intensity, duration and quality) between symptomatic irreversible pulpitis patients with and without referred pain.MethodsTwenty‐three patients with symptomatic irreversible pulpitis with referred pain and 12 patients without referred pain were included in this cross‐sectional study. The following outcomes were assessed: odontogenic spontaneous pain and its descriptors; pain evoked by cold stimulus and qualitative sensory testing before and after local anaesthesia; referred pain location; use of analgesic medication; complementary anaesthesia efficacy. T‐test, chi‐squared and McNemar tests were applied to the data (p < .50).ResultsPatients with referred pain presented a greater odontogenic pain intensity (p < .05) when considered the average of the last 24 h. These patients also showed higher pain rating and pain descriptors (p < .05). Intensity and duration of the pain evoked by cold stimulus in the non‐affected contralateral tooth at baseline were higher for patients with referred pain (p < .05).ConclusionSymptomatic irreversible pulpitis patients with referred pain present greater odontogenic spontaneous pain and a heightened pain sensitivity. Therefore, patients with referred pain seem more complex from a pain severity perspective, supporting the clinical utility of discriminating symptomatic irreversible pulpitis with and without referred pain.
Stable and efficient networks with neighborhood‐influenced externalities
Authors: Sun Ping , Parilina Elena 
Published: May 2024

AbstractThis paper analyzes the incentives of individuals to add or sever links that imply the formation of stable and efficient networks when a society is partitioned into groups. In terms of group partitioning, we determine cost topology by arranging a model in which a pair of players pays equally for the link connecting them and in which such a cost depends on the neighborhood composition of the pair when they belong to different groups. To be more precise, the cost of a link between players can be reduced if at least one of these players has neighbors from the group the other player belongs to. We examine specific network structures (i.e., minimal networks, minimally connected networks, complete networks, majority complete networks, and complete bipartite networks) when they are stable and efficient. Our analysis demonstrates how players' distribution among groups modifies the conditions of stability and efficiency. More significantly, we identify some fascinating phenomena which sharply contrast with most literature dealing with stable and efficient networks: (i) the nonminimal network can be stable in the absence of a benefit decay through the path; (ii) a player may prefer to link with players in other groups with a higher average link cost abandoning connection with the partners from her own group; (iii) it is impossible to ensure that the complete network will be efficient for partition with certain characteristics irrespective of the decay factor and the value of costs. The numerical examples are provided to illustrate our theoretical findings.