bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Acid Controlled Diastereoselectivity in Asymmetric Aldol Reaction of Cycloketones with Aldehydes Using Enamine‐Based Organocatalysts.
Authors: Gao Jinsuo , Bai Shiyang , Gao Qiang , Liu Yan , Yang Qihua 
Published: September 2011

AbstractA high syn‐selectivity is achieved in the asymmetric aldol reaction of cycloalkanones (I) with aromatic aldehydes (II) using a chiral diamine organocatalyst and succinic acid as an acidic additive capable of hydrogen bonding.
ChemInform Abstract: Synthesis of New Pyrazolopyrimidinedithiones and Pyrazolopyrimidinephosphines from Aminocyanopyrazoles.
Authors: Allouche Fatma , Chabchoub Fahker , Salem Mansour , Kirsch Gilbert 
Published: September 2011

AbstractTitle compounds (III) and (V) are formed in a one‐pot procedure via Dimroth rearrangement of intermediates obtained primarily from the reaction of pyrazoles (I) with carbon disulfide and Lawesson reagent, respectively.
ChemInform Abstract: Vanadium‐Catalyzed Atmospheric Oxidation of Benzyl Alcohols Using Water as Solvent.
Authors: Kodama Shintaro , Hashidate Suguru , Nomoto Akihiro , Yano Shigenobu , Ueshima Michio , Ogawa Akiya 
Published: September 2011

AbstractAn inexpensive and environmentally benign method for the oxidation of benzyl alcohols is reported employing a vanadium catalyst and using water as reaction solvent under an atmospheric pressure of oxygen.
ChemInform Abstract: Palladium‐Catalyzed Oxidative Borylative Carbocyclization of Enallenes.
Authors: Persson Andreas K. A. , Jiang Tuo , Johnson Magnus T. , Baeckvall Jan‐E. 
Published: September 2011

AbstractThe protocol gives alkylboronates in good yield and stereoselectivity and requires only minimal amounts of reactants.
ChemInform Abstract: Ionic Liquid‐Accelerated Allylation of Carbonyl Compounds with a Catalytic Amount of Indium Generated from in situ Reduction of InCl3 with Aluminum.
Authors: Hirashita Tsunehisa , Sato Yuki , Yamada Dai , Takahashi Fusako , Araki Shuki 
Published: September 2011

AbstractA combination of catalytic InCl3 and stoichiometric aluminum efficiently mediates the allylation of carbonyl compounds in an ionic liquid/H2O solvent system.
ChemInform Abstract: Alkenylphosphonates: Unexpected Products from Reactions of Methyl 2‐[(Diethoxyphosphoryl)methyl]benzoate under Horner—Wadsworth—Emmons Conditions.
Authors: Baird Lynton J. , Colomban Cedric , Turner Claire , Teesdale‐Spittle Paul H. , Harvey Joanne E. 
Published: September 2011

AbstractReaction of benzoate (I) with several aldehydes affords alkenylphosphonates (III) as the major products, together with the expected Horner—Wadsworth—Emmons products (IV).
ChemInform Abstract: New Effective Synthetic Method for Preparation of N,N‐Dichlorocarbamates.
Authors: Gutch P. K. , Singh Ravindra , Prabha S. , Suryanarayana M. V. S. 
Published: September 2011

AbstractA rapid, efficient, and easy to scale method for the conversion of carbamates into the corresponding N,N‐dichlorocarbamates is described.
ChemInform Abstract: Nickel‐Catalyzed Allylic Substitution of Simple Alkenes.
Authors: Matsubara Ryosuke , Jamison Timothy F. 
Published: September 2011

AbstractA variety of 1,4‐dienes is prepared with high regioselectivity by Ni—phosphine‐catalyzed allylic substitution of allylic alcohols, allylsilanes, vinylepoxides and vinyltetrahydrofuran derivatives with simple alkenes (in parts published previously).
ChemInform Abstract: Direct Reductive Amination of Aromatic Aldehydes Catalyzed by Gold(I) Complex under Transfer Hydrogenation Conditions.
Authors: Zhang Ming , Yang Hongwei , Zhang Yan , Zhu Chengjian , Li Wei , Cheng Yixiang , Hu Hongwen 
Published: September 2011

AbstractAn efficient method is elaborated for the gold‐catalyzed reductive amination of aldehydes (I) and ketones (IV) with an equimolar amount of anilines in the presence of Hantzsch ester as reducing agent.
ChemInform Abstract: New Simple and Recyclable O‐Acylation Serine Derivatives as Highly Enantioselective Catalysts for the Large‐Scale Asymmetric Direct Aldol Reactions in the Presence of Water.
Authors: Wu Chuanlong , Fu Xiangkai , Li Shi 
Published: September 2011

AbstractThe new serine derivative efficiently promotes the reaction of ketones with aromatic aldehydes in water.
ChemInform Abstract: Highly Efficient and Modularly Tuned Bicyclic Organocatalyst for the Enantioselective Michael Addition of Aldehydes to Nitroalkenes.
Authors: Xiao Jian , Xu Feng‐Xia , Lu Yun‐Peng , Liu Yan‐Ling , Loh Teck‐Peng 
Published: September 2011

AbstractThe catalyst system ICA/DMAP is successfully applied to the reaction to give syn‐adducts (III) as major products with good levels of enantioselectivity.
ChemInform Abstract: Palladium Nanoparticles on Graphite Oxide as Catalyst for Suzuki—Miyaura, Mizoroki—Heck, and Sonogashira Reactions.
Authors: Rumi Luigi , Scheuermann Gil M. , Muelhaupt Rolf , Bannwarth Willi 
Published: September 2011

AbstractThe reaction of a variety of aryl bromides with ester (II) affords the products with moderate to good high yields.
ChemInform Abstract: Facile Synthesis of Symmetrical 3,3‐Diarylacrylates by a Heck—Matsuda Reaction: An Expedient Route to Biologically Active Indanones.
Authors: Taylor Jason G. , da Silva Ribeiro Rodrigo , Correia Carlos Roque D. 
Published: September 2011

AbstractA regioselective Heck—Matsuda reaction is developed to synthesize various title compounds as ubiquitous structural motifs.
ChemInform Abstract: Heterogeneous Copper‐Free Sonogashira Reaction Catalyzed by a Reusable Palladium Schiff Base Complex in Water.
Authors: He Ying , Cai Chun 
Published: September 2011

AbstractThe reaction of various aryl iodides tolerates electron‐donating and ‐withdrawing substituents at para‐, meta‐ and ortho positions.
ChemInform Abstract: C—H Amination/Cyclocarbonylation of Allene Carbamates: A Versatile Platform for the Synthesis of α,β‐Unsaturated γ‐Lactams.
Authors: Grigg R. David , Schomaker Jennifer M. , Timokhin Vitaliy 
Published: September 2011

AbstractThe ratio of CH‐amidation to aziridination in a series of allene carbamates is investigated with respect to conditions and substrate structure.
ChemInform Abstract: Catalytic Asymmetric Synthesis of Trisubstituted Aziridines.
Authors: Huang Li , Wulff William D. 
Published: September 2011

AbstractN‐Boc imines and some related compounds react with both α‐diazo oxazolidinones and α‐diazo esters to give trisubstituted aziridines with excellent diastereo‐ and enantioselectivities.
ChemInform Abstract: Novel Synthetic Methodologies. Part 210. Indium(III) Chloride‐Catalyzed Conversion of {[(Benzyloxy)carbonyl]amino}‐Substituted Sulfones with 2‐[(Trimethylsilyl)oxy]furan: A Facile Access to γ‐Butenolactone Derivatives Containing a Protected Amino Group.
Authors: Das Biswanath , Sudhakar Chithaluri , Reddy Parigi Raghavendar , Kashanna Jajula 
Published: September 2011

AbstractVarious racemic γ‐butenolactones are prepared with moderate anti‐selectivities tolerating aromatic, heteroaromatic and aliphatic substituents and a range of functional groups.
ChemInform Abstract: Asymmetric Vinylogous Michael Reaction of α,β‐Unsaturated Aldehyde with Buteno‐4‐lactone.
Authors: Luo Xiaoyan , Zhou Zhiqiang , Yu Feng , Li Xin , Liang Xinmiao , Ye Jinxing 
Published: September 2011

Abstractusing the Joergensen—Hayashi catalyst
ChemInform Abstract: Cesium Carbonate as a Heterogeneous Base Catalyst for Synthesis of 2‐Aminothiophenes via Gewald Reaction.
Authors: Moeinpour Farid , Omidinia Raheleh , Dorostkar‐Ahmadi Nadieh , Khoshdeli Bentalhoda 
Published: September 2011

AbstractCesium carbonate can readily be separated from the reaction mixture and reused at least three times without significant loss of activity.
ChemInform Abstract: Effective Synthesis of Symmetrical Oxygen‐ and Nitrogen‐Heterocycles from Electron‐Deficient Alkynes via the Catalysis of Electrogenerated Base and Fe3+ Ions.
Authors: Li Chuan‐Hua , Yuan Gao‐Qing , Zheng Jun‐Hua , He Zai‐Jun , Qi Chao‐Rong , Jiang Huan‐Feng 
Published: September 2011

AbstractIt provides a new method to prepare highly functionalized pyrroles and furans.
ChemInform Abstract: Use of 1,3‐Dipolar Reactions for the Preparation of SF5‐Substituted Five‐Membered Ring Heterocycles. Pyrroles and Thiophenes.
Authors: Dolbier William R. Jr. , Zheng Zhaoyun 
Published: September 2011

AbstractA variety of SF5‐substituted pyrrole and hitherto not reported SF5‐substituted thiophene derivatives are synthesized by 1,3‐dipolar cycloaddition reactions of SF5‐substituted alkynes (I) with in situ generated azomethine ylides or thiocarbonyl ylides, respectively.
ChemInform Abstract: Chiral Phosphoric Acid‐Catalyzed Friedel—Crafts Alkylation Reaction of Indoles with Racemic Spiro Indolin‐3‐ones.
Authors: Yin Qin , You Shu‐Li 
Published: September 2011

AbstractThe resulting adducts bearing a quaternary stereocenter are obtained with excellent enantioselectivities.
ChemInform Abstract: A Scalable Nenitzescu Synthesis of 2‐Methyl‐4‐(trifluoromethyl)‐1H‐indole‐5‐carbonitrile.
Authors: Boros Eric E. , Kaldor Istvan , Turnbull Philip S. 
Published: September 2011

AbstractThe title compound (VIII) is a key intermediate in the synthesis of selective androgen receptor modulators.
ChemInform Abstract: Reactions of 2‐(Diformylmethylidene)‐3,3‐dimethylindole with Hydrazides: Synthesis of New Pyrazolylindolenine Derivatives — The Unprecedented One‐Pot Pyrazole—Thiadiazole Double Annulation.
Authors: Khaledi Hamid , Ali Hapipah Mohd , Thomas Noel Francis , Ng Seik Weng 
Published: September 2011

AbstractThe reactions of compound (I) lead to the expected new compounds (III), (V), (VII), and (X), to the by‐product (VIII), and to the unprecedented formation of the compound (XI).
ChemInform Abstract: Nucleophilic Substitution in 1‐Methyl‐3,4,5‐trinitro‐1H‐pyrazole
Authors: Dalinger Igor L. , Vatsadze Irina A. , Shkineva Tatyana K. , Popova Galina P. , Shevelev Svyatoslav A. 
Published: September 2011

Abstractby amines, NH‐azoles, phenols, thiols, and oximes
ChemInform Abstract: An Easy One‐Step Photocatalytic Synthesis of 1‐Aryl‐2‐alkylbenzimidazoles by Platinum Loaded TiO2 Nanoparticles under UV and Solar Light.
Authors: Selvam K. , Swaminathan M. 
Published: September 2011

AbstractPt loaded on TiO2 nanoparticles promotes the photolytic reaction of N‐monosubstituted o‐phenylenediamines (I) with aliphatic alcohols to give 1,2‐disubstituted benzimidazoles directly.
ChemInform Abstract: Enantioselective Synthesis of Cyclic Carbamimidates via a Three‐Component Reaction of Imines, Terminal Alkynes, and p‐Toluenesulfonylisocyanate Using a Monophosphine Gold(I) Catalyst.
Authors: Campbell Matthew J. , Toste F. Dean 
Published: September 2011

AbstractIn all cases, a mixture of five‐ and six‐membered rings is obtained favoring oxazole derivatives (ratio 1,6:1 up to ≥ 20:1).
ChemInform Abstract: New Approach to Oligotriazoles Using a Cobalt Complex of Propargyl Azides as a Synthetic Component.
Authors: Tsukada Yuichi , Yamada Kohei , Kunishima Munetaka 
Published: September 2011

AbstractThe target compounds are prepared by repetitive sequence involving a 1,3‐dipolar cycloaddition of alkynes with alkyne—cobalt complexes and subsequent oxidative deprotection.
ChemInform Abstract: Dye‐Sensitized Solar Cells Based on Novel Diphenylpyran Derivatives.
Authors: Bolag Altan , Nishida Jun‐ichi , Hara Kohjiro , Yamashita Yoshiro 
Published: September 2011

AbstractA series of novel diphenylpyran derivatives (VII) is synthesized as photosensitizers of dye‐sensitized solar cells.
ChemInform Abstract: Environmentally Benign Syntheses of Flavanones.
Authors: Chen Po‐Yuan , Wang Tzu‐Pin , Chiang Michael Y. , Huang Keng‐Shian , Tzeng Cherng‐Chyi , Chen Yi‐Long , Wang Eng‐Chi 
Published: September 2011

AbstractThe mild, efficient, and environmentally friendly method allows to prepare biologically important flavanones.
ChemInform Abstract: L‐Proline Catalyzed Condensation—Cyclization Tandem Process: Facile and Effective Synthesis of 3‐Polyfluoroalkanesulfonyl Coumarin.
Authors: Han Jainwei , Xin Yong , Zhao Jingwei , Zhu Shizheng 
Published: September 2011

AbstractNitrile (I) reacts readily with aldehydes (II) to afford acrylonitriles (III), whilst the analogous reaction of esters (IV) with salicylaldehydes (V) gives rise to coumarin derivatives (VI) in good yields.
ChemInform Abstract: Synthesis of Novel Quinoline Analogues of Nimesulide: An Unusual Observation.
Authors: Reddy Lingam Venkata , Nakka Mamatha , Suman Alishetty , Ghosh Soumen , Helliwell Madeleine , Mukkanti Khagga , Mukherjee Alok Kumar , Pal Sarbani 
Published: September 2011

AbstractTreating N‐acetyl derivative (I) with the Vilsmeier—Haack reagent results in the formation of the unexpected N‐formyl derivative (III) along with the expected product (IV).
ChemInform Abstract: In vitro Cytotoxic Evaluation of Some New Heterocyclic Sulfonamide Derivatives.
Authors: Ghorab Mostafa M. , Al‐Said Mansour S. , El‐Hossary Ebaa M. 
Published: September 2011

AbstractA variety of new quinoline, pyrimidoquinoline and oxazinoquinoline derivatives bearing a sulfonamide moiety is synthesized and evaluated for their anticancer activities.
ChemInform Abstract: Synthesis of Isoquinolines from α‐Aryl Vinyl Azides and Internal Alkynes by Rh—Cu Bimetallic Cooperation.
Authors: Wang Yi‐Feng , Toh Kah Kah , Lee Jian‐Yuan , Chiba Shunsuke 
Published: September 2011

AbstractOptimized reaction condition including a Rh/Cu‐bimetallic catalyst system.
ChemInform Abstract: Simple Efficient Synthesis of 4‐Aminoquinazoline via Amidine of N‐Arylamidoxime.
Authors: Patil Sachin S. , Mhaske Pravin C. , Patil Sachin V. , Bobade Vivek D. 
Published: September 2011

AbstractExtra cyano‐substituents remain unaffected by using the presented method, cf.
ChemInform Abstract: Synthesis of Novel 2‐Alkoxy(aralkoxy)‐4H‐[1,2,4]triazolo[1,5‐a]quinazolin‐5‐ones Starting with Dialkyl‐N‐cyanoimidocarbonates.
Authors: Al‐Salahi Rashad , Geffken Detlef 
Published: September 2011

AbstractThe title compounds (III) can also be converted to a variety of derivatives.
ChemInform Abstract: One‐Pot Synthesis of 2‐Substituted 4‐Aryl‐4,5‐dihydro‐3,1‐benzoxazepines from 2‐(2‐Aminophenyl)‐1‐arylethanols via Dehydration of the Corresponding Amides.
Authors: Fukamachi Shuhei , Konishi Hisatoshi , Kobayashi Kazuhiro 
Published: September 2011

AbstractThe reaction proceeds under mild conditions from easily available starting materials.
ChemInform Abstract: Synthesis of the B‐seco Limonoid Scaffold.
Authors: Schuster Hannah , Martinez Remi , Bruss Hanna , Antonchick Andrey P. , Kaiser Markus , Schuermann Markus , Waldmann Herbert 
Published: September 2011

AbstractThe B‐seco limonoid scaffold (V) is prepared via a ring closing metathesis of diene (II) and an Ireland—Claisen rearrangement of ester (IV) as key steps.
ChemInform Abstract: Dialiumoside, an Olean‐18‐ene Triterpenoid from Dialium excelsum
Authors: Awantu Angelbert F. , Lenta Bruno N. , Bogner Tobias , Fongang Yanick F. , Ngouela Silvere , Wansi Jean D. , Tsamo Etienne , Sewald Norbert 
Published: September 2011

Abstractisolation, structure elucidation and cytotoxic activity
ChemInform Abstract: New Antiplasmodial Indole Alkaloids from Hunteria zeylanica.
Authors: Nugroho Alfarius E. , Sugai Masatomo , Hirasawa Yusuke , Hosoya Takahiro , Awang Khalijah , Hadi A. Hamid A. , Ekasari Wiwied , Widyawaruyanti Aty , Morita Hiroshi 
Published: September 2011

AbstractTwo new indole alkaloids, bisnicalaterine D(I), possessing an eburnane and a corynanthe type skeleton, and nicalaterine A(II) are isolated from the bark of H.zeylanica. The antimalarial activity of the new compounds as well as that of three previously isolated bisindole alkaloids, bisnicalaterines A—C, is investigated.
ChemInform Abstract: Phenylethanoid Glycosides from Digitalis purpurea L.
Authors: Jin Qinglong , Jin Hong‐Guang , Shin Ji Eun , Hong Jongki , Woo Eun‐Rhan 
Published: September 2011

AbstractThe new phenylethanoid glycosides, purpureaside D (Ia) and purpureaside E (Ib), are isolated together with two known phenylethanoid glycosides.
ChemInform Abstract: Phenolic Compounds with NF‐ϰB Inhibitory Effects from the Fungus Phellinus baumii.
Authors: Wu Chang‐Sheng , Lin Zhao‐Min , Wang Lo‐Ning , Guo Dong‐Xiao , Wang Shu‐Qi , Liu Yong‐Qing , Yuan Hui‐Qing , Lou Hong‐Xiang 
Published: September 2011

AbstractNine new compounds, five hispidin‐derived polyphenols, phellibaumin A (III), B (II), C (IV), D (Ia), and E (Ib) benzyl dihydroflavones methylphelligrin A (Vb) and B (Va) and their epimers are isolated from the fruit body of P.
ChemInform Abstract: Radiosynthesis of [11C]Vandetanib and [11C]chloro‐Vandetanib as New Potential PET Agents for Imaging of VEGFR in Cancer.
Authors: Gao Mingzhang , Lola Christian M. , Wang Min , Miller Kathy D. , Sledge George W. , Zheng Qi‐Huang 
Published: September 2011

AbstractVandetanib and chloro‐vandetanib are synthesized following published procedures.
ChemInform Abstract: Survey of Briarane‐Type Diterpenoids. Part 4.
Authors: Sung Ping‐Jyun , Su Jui‐Hsin , Wang Wei‐Hsien , Sheu Jyh‐Horng , Fang Lee‐Shing , Wu Yang‐Chang , Chen Yung‐Husan , Chung Hsu‐Ming , Su Yin‐Di , Chang Yu‐Chia 
Published: September 2011

AbstractReview: structures, names and bioactivities of 90 briarane‐type diterpenoids; 45 refs.
Enantiomers of naringenin as pleiotropic, stereoselective inhibitors of cytochrome P450 isoforms
Authors: Lu Wenjie Jessie , Ferlito Valentina , Xu Cong , Flockhart David Alastair , Caccamese Salvatore 
Published: September 2011

AbstractInteractions between naringenin and the cytochrome P450 (CYP) system have been of interest since the first demonstration that grapefruit juice reduced CYP3A activity. The effects of naringenin on other CYP isoforms have been less investigated. In addition, it is well known that interactions with enzymes are often stereospecific, but due to the lack of readily available pure naringenin enantiomers, the enantioselectivity of its effects has not been characterized. We isolated pure naringenin enantiomers by chiral high‐performance liquid chromatography and tested the ability of (R)‐,(S)‐ and rac‐naringenin to inhibit several important drug‐metabolizing CYP isoforms using recombinant enzymes and pooled human liver microsomes. Naringenin was able to inhibit CYP19, CYP2C9, and CYP2C19 with IC50 values below 5 μM. No appreciable inhibition of CYP2B6 or CYP2D6 was observed at concentrations up to 10 μM. Whereas (S)‐naringenin was 2‐fold more potent as an inhibitor of CYP19 and CYP2C19 than (R)‐naringenin, (R)‐naringenin was 2‐fold more potent for CYP2C9 and CYP3A. Chiral flavanones like naringenin are difficult to separate into their enantiomeric forms, but enantioselective effects may be observed that ultimately impact clinical effects. Inhibition of specific drug metabolizing enzymes by naringenin observed in vitro may be exploited to understand pharmacokinetic changes seen in vivo. Chirality, 2011. © 2011 Wiley‐Liss, Inc.
From Material and Energy Flow Analysis to Carbon Footprinting – Suggestions from Cost Accounting
Authors: Schmidt Mario 
Published: September 2011

AbstractIn der Ökobilanzierung werden Material‐ und Energieflussanalysen für die sogenannte Sachbilanz eingesetzt. Der Carbon Footprint vereinfacht die Ökobilanz durch seinen Bezug auf eine einzige Ergebnisgröße. Allerdings treten dann einige Parallelen zur Kostenrechnung deutlich zu Tage, etwa können die Emissionsfaktoren von Rohstoffen oder anderen Vorleistungen als Preise aufgefasst werden. Bekannte Verfahren aus der Kostenrechnung können für die Berechnung und Auswertung eingesetzt werden und Aspekte wie Kuppelprozesse, Recyclingprozesse, Kreislaufführungen oder Allokationen elegant lösen. Herausforderungen beim Carbon Footprint sind der Umgang mit der Speicherung von Kohlenstoff, mit Kohlendioxid biogenen Ursprungs und der Berücksichtigung von Landnutzungsänderungen. In dem Beitrag wird aufgezeigt, wie mit einer stringenten Methodik solche Fragen in Material‐ und Energieflussanalysen behandelt werden können.
Peak and decline in cancer incidence, mortality, and prevalence at old ages
Authors: Harding Charles , Pompei Francesco , Wilson Richard 
Published: September 2011

AbstractBACKGROUND:Cancer incidence and mortality increase with age through much of adulthood, but earlier work has found that these rates decline among the very elderly. To compare incidence and mortality at the oldest ages, the authors investigated both in the same large population, which comprised 9.5% of the United States in 2000. The authors also report age‐specific prevalence among the elderly, which has received little attention.METHODS:Twenty‐three cancer types were studied in men, and 24 cancer types were studied in women. Patient records were obtained from the SEER 9 cancer registries, and population figures were taken from the 2000 US Census. The authors explored the reliability of census data on the oldest old, which has been questioned.RESULTS:Age‐specific incidence, prevalence, and mortality results are presented for the years 1998 to 2002. Incidence and mortality usually decreased or plateaued at very old ages. Prevalence usually decreased swiftly at ages >90 years. When there was statistical power, incidence normally peaked between ages 75 years and 90 years, dropping abruptly afterward. With several large exceptions, peak incidence and mortality coincided within ±5 years. Both rates often trended toward zero among centenarians, who may be asymptomatic or insusceptible.CONCLUSIONS:The current results were found to be consistent with autopsy and survival studies. Most age‐specific models of carcinogenesis are based on cancer rate data for ages <85 years. The authors argue that these models could not fit the current results without fundamental modification and outline biologic mechanisms for such modification, mostly cellular and tissue senescence. They also recommend caution to researchers who use census data on the very elderly. Cancer 2012;. © 2011 American Cancer Society.
MutYH mutation carriers have increased breast cancer risk
Authors: Rennert Gad , Lejbkowicz Flavio , Cohen Ilana , Pinchev Mila , Rennert Hedy S. , Barnett‐Griness Ofra 
Published: September 2011

AbstractBACKGROUND:Variants of the mutY homolog gene MutYH, a DNA repair gene, are associated with increased risk of colorectal cancer; however, it remains unclear whether these variants also are associated with the risk of other cancers. The authors studied the risk of breast cancer associated with MutYH variants in a unique ethnic group of Sephardi Jews in Israel with a high prevalence of MutYH mutations.METHODS:The study participants were 930 Sephardi Jewish women of North African origin who were recruited into the population‐based case‐control Breast Cancer in Northern Israel Study (BCINIS) either as breast cancer cases or as healthy controls. All participants contributed a blood sample and completed an interview. Two MutYH variants, a glycine‐to‐aspartic acid substitution at codon 396 (G396D) and a tyrosine‐to‐cysteine substitution at codon 179 (Y179C), were studied.RESULTS:In the Sephardi Jews, among the healthy controls, 20 women (3.7%) were homozygote or heterozygote carriers of the G396D variant, and 4 women (0.7%) were heterozygote carriers of the Y179C variant. Breast cancer cases had a 6.7% prevalence of G396D, yielding a significantly elevated risk estimate for breast cancer (odds ratio, 1.86; 95% confidence interval, 1.02‐3.39; P = .039). The tumors detected in carriers with MutYH variants were similar in characteristics to those without MutYH variants, as was the age at diagnosis.CONCLUSIONS:Carriers of variants in MutYH, although not very common, may have an increased risk of breast cancer in Jews of North African origin. Identification of such carriers and special surveillance protocols may be warranted. Cancer 2012;. © 2011 American Cancer Society.