bluuebunny/crossref_metadata_2025_split huggingface dataset:
From yield stress to elastic instabilities: Tuning the extensional behavior of elastoviscoplastic fluids
Authors: Abdelgawad Mohamed S , Haward Simon J , Shen Amy Q , Rosti Marco E 
Published: June 2024

Abstract
In this study, we delve into the intricacies of elastoviscoplastic (EVP) fluids, particularly focusing on how polymer additives influence their extensional behavior. Our findings reveal that polymer additives significantly alter the extensional properties of the EVP fluids, such as relaxation time and extensional stresses while having negligible impact on the shear rheology. Interestingly, the modified fluids exhibit a transition from yield stress-like behavior to viscoelastic-like behavior under high extensional rates, ultimately leading to destabilization under extreme deformation. This research enhances the fundamental understanding of EVP fluids and highlights potential advancements in applications, especially in precision-demanding fields like 3D printing.
Fiscal Federalism, ARPA, and the Politics of Repair
Authors: Xu Yuanshuo , Warner Mildred E 
Published: June 2024

AbstractThe American Rescue Plan Act (ARPA) represents a politics of repair for American Federalism. The unprecedented size, scope, and timeliness of ARPA enable local governments to address some of the structural inequities laid bare by the pandemic. U.S. Federalism was broken before the pandemic, with states exerting a triangle of pressures that created a tightening vice on local government through revenue restrictions, downloading expenditure responsibilities, and restricting local policy authority. Recent federal action through ARPA has helped ease the pressure on local revenue, enabling new expenditures and new policy action. ARPA is larger, longer, and more expansive than the American Rescue and Recovery Act passed after the Great Recession. We analyze revenue and expenditure data for all local governments and special districts from 2000 through 2022. ARPA represents a layer in the palimpsest of federalist policy, a politics of repair, that reminds us that more cooperative federal-local relations are possible.
Pneumococcal vaccine uptake in patients with inflammatory arthritis: a single centre cohort study
Authors: Nagra Deepak , Bechman Katie , Russell Mark D , Yang Zijing , Adas Maryam A , Molabanti Hemanth Kumar , Khan Asim , Wincup Chris , Alveyn Edward , Baldwin Christopher , Rutherford Andrew I , Subesinghe Sujith , Cope Andrew , Galloway James B 
Published: June 2024

AbstractIntroductionCurrent guidelines recommend pneumococcal vaccination in individuals who are over the age of 65 or are immunosuppressed due to a disease or treatment. The objective of this study was to assess vaccine uptake rates in people with inflammatory arthritis for the pneumococcal, influenza and Covid-19 vaccines and factors determining uptake.MethodsWe conducted a retrospective single centre cohort study in the UK of individuals with rheumatoid arthritis, psoriatic arthritis and axial spondyloarthritis between October and December 2023. Data were collected for age, gender, co-morbidities, immunosuppressive therapies and dates of vaccines. Logistic regression was used to evaluate predictors of vaccine uptake, with adjustments for demographic and clinical factors.ResultsNine hundred and six individuals were identified; 46% were receiving treatment with conventional synthetic DMARD (csDMARD), 26% were on biologic monotherapy, and 23% were on both biologic and csDMARDs. Three hundred and sixteen individuals (35%) received a pneumococcal vaccine, lower than uptake for influenza (63%) and Covid-19 (87%) vaccines. Predictors of pneumococcal vaccine uptake included age, with older patients more likely to be vaccinated (odds ratio [OR] for age ≥ 65 years: 1.67; 95% CI: 1.21, 2.29). Those on biologic therapy demonstrated higher likelihood of vaccination (OR for biologic therapy: 1.81; 95% CI: 1.33, 2.47). Additional Joint Committee on Vaccination and Immunisation Green Book indicators also positively influenced vaccine uptake (OR: 1.67; 95% CI: 1.19, 2.33).ConclusionPneumococcal vaccine uptake in inflammatory rheumatic diseases is low, especially in younger patients and those not on biologic therapy. The study highlights the need for a focused approach, distinct from strategies for other vaccines, to address this public health challenge.
The exposure analysis of the long-term broadband EMF monitoring in the campus area of the University of Novi Sad
Authors: Kljajic Dragan , Djuric Nikola , Skoric Tamara , Djuric Snezana 
Published: June 2024

Abstract
Due to wide prevalence of electromagnetic field (EMF) sources in human surrounding, EMF-level measurements and corresponding exposure assessment have imposed as an important topic. With an intention to present an approach to the long-term exposure assessment in EMF RATEL network, this paper conveys a high-level statistical analysis of the high-frequency exposure data, acquired during the 5-y time period, for the case study of monitoring sensor installed in the area of the Novi Sad University campus. Time series of exposure values were averaged on a daily, weekly, and monthly basis, and their yearly comparison was performed. Results showed clear differences between the day and night hours, as well between working and weekend days. Regarding exposure values, averaged on the monthly basis, the impact of COVID-19 pandemic in 2020 and 2021 can be noticed. Finally, the highest obtained exposure values (electric field squared) were 22 times below the maximal allowable level, according to the Serbian legislation.
Long-term monitoring of outdoor natural gamma absorbed dose rate in air in Bengaluru, Karnataka, India
Authors: Mitra Pratip , Srivastava Saurabh , Reddy Gade Priyanka , Garg Saurabh , Kumar Aerattukkara Vinod 
Published: June 2024

Abstract
This research forms a part of the comprehensive Indian Environmental Radiation Monitoring Network program, focusing on the continuous measurement of absorbed dose rate in outdoor air due to natural gamma radiation (cosmic and terrestrial) in Bengaluru, Karnataka, India. Over the course of a decade (2013–2023), data were collected from 41 monitoring locations in the city using permanently field-installed Geiger-Mueller detector-based environmental radiation monitors. This paper presents an analysis of the extensive long-term monitoring results. The mean absorbed gamma dose rate in outdoor air across the monitoring locations ranged from 84 ± 9 to 156 ± 4 nGy.h−1, with a calculated mean value of 124 ± 15 nGy.h−1. The estimated mean annual effective dose due to outdoor natural gamma radiation varied from 0.10 ± 0.01 to 0.19 ± 0.01 mSv.y−1, with an overall mean of 0.15 ± 0.02 mSv.y−1.
Exploring the clinical transition of engineered exosomes designed for intracellular delivery of therapeutic proteins
Authors: Kim Minseong , Choi Hojun , Jang Deok-Jin , Kim Hye-Jung , Sub Yujin , Gee Heon Yung , Choi Chulhee 
Published: June 2024

Abstract
Extracellular vesicles, particularly exosomes, have emerged as promising drug delivery systems owing to their unique advantages, such as biocompatibility, immune tolerability, and target specificity. Various engineering strategies have been implemented to harness these innate qualities, with a focus on enhancing the pharmacokinetic and pharmacodynamic properties of exosomes via payload loading and surface engineering for active targeting. This concise review outlines the challenges in the development of exosomes as drug carriers and offers insights into strategies for their effective clinical translation. We also highlight preclinical studies that have successfully employed anti-inflammatory exosomes and suggest future directions for exosome therapeutics. These advancements underscore the potential for integrating exosome-based therapies into clinical practice, heralding promise for future medical interventions.
Network analysis of toxic endpoints of fungicides in zebrafish
Authors: Pamanji Rajesh , Ragothaman Prathiviraj , Koigoora Srikanth , Sivan Gisha , Selvin Joseph 
Published: June 2024

Abstract
Zebrafish being the best animal model to study, every attempt has been made to decipher the toxic mechanism of every fungicide of usage and interest. It is important to understand the multiple targets of a toxicant to estimate the toxic potential in its totality. A total of 22 fungicides of different classes like amisulbrom, azoxystrobin, carbendazim, carboxin, chlorothalonil, difenoconazole, etridiazole, flusilazole, fluxapyroxad, hexaconazole, kresoxim methyl, mancozeb, myclobutanil, prochloraz, propiconazole, propineb, pyraclostrobin, tebuconazole, thiophanate-methyl, thiram, trifloxystrobin and ziram were reviewed and analyzed for their multiple explored targets in zebrafish. Toxic end points in zebrafish are highly informative when it comes to network analysis. They provide a window into the molecular and cellular pathways that are affected by a certain toxin. This can then be used to gain insights into the underlying mechanisms of toxicity and to draw conclusions on the potential of a particular compound to induce toxicity. This knowledge can then be used to inform decisions about drug development, environmental regulation, and other areas of research. In addition, the use of zebrafish toxic end points can also be used to better understand the effects of environmental pollutants on ecosystems. By understanding the pathways affected by a given toxin, researchers can determine how pollutants may interact with the environment and how this could lead to health or environmental impacts.
Prospective Randomized Controlled Trial Comparing Anesthetic Management With Remimazolam Besylate and Flumazenil Versus Propofol During Awake Craniotomy Following an Asleep-awake-asleep Method
Authors: Sato Takehito , Ando Takahiro , Ozeki Kanako , Asano Ichiko , Kuwatsuka Yachiyo , Ando Masahiko , Motomura Kazuya , Nishiwaki Kimitoshi 
Published: June 2024

Background:
Awake craniotomy is performed to resect brain tumors in eloquent brain areas to maximize tumor reduction and minimize neurological damage. Evidence suggests that intraoperative anesthetic management of awake craniotomy with remimazolam is safe. We compared the time to arousal and efficacy of anesthetic management with remimazolam and propofol during awake craniotomy.

Methods:
In a single-institution randomized, prospective study, patients who underwent elective awake craniotomy were randomized to receive remimazolam and reversal with flumazenil (group R) or propofol (group P). The primary end point was time to awaken. Secondary end points were time to loss of consciousness during induction of anesthesia, the frequency of intraoperative complications (pain, hypertension, seizures, nausea, vomiting, and delayed arousal), and postoperative nausea and vomiting. Intraoperative task performance was assessed using a numerical rating scale (NRS) score.

Results:
Fifty-eight patients were recruited, of which 52 (26 in each group) were available for the efficacy analysis. Patients in group R had faster mean (±SD) arousal times than those in the P group (890.8±239.8 vs. 1075.4±317.5 s; P=0.013)and higher and more reliable intraoperative task performance (NRS score 8.81±1.50 vs. 7.69±2.36; P=0.043). There were no significant intraoperative complications.

Conclusions:
Compared with propofol, remimazolam was associated with more rapid loss of consciousness and, after administration of flumazenil, with faster arousal times and improved intraoperative task performance.
Optic Nerve Sheath Diameter Point-of-Care Ultrasonography Quality Criteria Checklist: An International Consensus Statement on Optic Nerve Sheath Diameter Imaging and Measurement*
Authors: Hirzallah Mohammad I. , Lochner Piergiorgio , Hafeez Muhammad Ubaid , Lee Andrew G. , Krogias Christos , Dongarwar Deepa , Hartman Nicholas D. , Ertl Michael , Robba Chiara , Malojcic Branko , Valaikiene Jurgita , Sarwal Aarti , Hakimi Ryan , Schlachetzki Felix ,   for the Optic Nerve Sheath Diameter Point-of-Care Ultrasonography Quality Criteria Checklist (ONSD POCUS QCC) Expert Panelists
Published: June 2024

OBJECTIVES:
To standardize optic nerve sheath diameter (ONSD) point-of-care ultrasonography (POCUS) and improve its research and clinical utility by developing the ONSD POCUS Quality Criteria Checklist (ONSD POCUS QCC).

DESIGN:
Three rounds of modified Delphi consensus process and three rounds of asynchronous discussions.

SETTING:
Online surveys and anonymous asynchronous discussion.

SUBJECTS:
Expert panelists were identified according to their expertise in ONSD research, publication records, education, and clinical use. A total of 52 panelists participated in the Delphi process.

INTERVENTIONS:
None.

MEASUREMENTS AND MAIN RESULTS:
Three Delphi rounds and three asynchronous discussion rounds generated consensus on quality criteria (QC). This started with 29 QC in addition to other QC proposed by expert panelists. The QC items were categorized into probe selection, safety, body position, imaging, measurement, and research considerations. At the conclusion of the study, 28 QC reached consensus to include in the final ONSD POCUS QCC. These QC were then reorganized, edited, and consolidated into 23 QC that were reviewed and approved by the panelists.

CONCLUSIONS:
ONSD POCUS QCC standardizes ONSD ultrasound imaging and measurement based on international consensus. This can establish ONSD ultrasound in clinical research and improve its utility in clinical practice.
Association between birth weight and risk of nonneurological childhood cancers: a systematic review and meta-analysis
Authors: Rashti Roya , Ghasemi Faezeh , Poorolajal Jalal 
Published: June 2024

Objectives
This systematic review aims to synthesize the available literature to determine the association between birthweight and the risk of nonneurological childhood cancers.

Methods
We conducted a systematic search of PubMed, Web of Science, and Scopus databases up to May 2023 to identify observational studies. Heterogeneity between studies was evaluated using the I
2 statistics. Publication bias was assessed using Begg and Egger tests. We calculated the odds ratio (OR) or risk ratio (RR) with a 95% confidence interval (CI) using a random-effects model.

Results
Of 11 034 studies retrieved from the search, 56 studies (including 10 568 091 participants) were eligible. The ORs (95% CI) of low (<2500 g) versus normal birthweight (2500–4000 g) and childhood cancers were as follows: leukemia, 0.92 (0.77–1.11); acute lymphoblastic leukemia, 0.82 (0.72–0.94); acute myeloid leukemia, 0.98 (0.77–1.24); lymphoma, 0.99 (0.47–2.10); Hodgkin, 0.79 (0.61–1.03); non-Hodgkin, 0.85 (0.60–1.20); neuroblastoma, 1.34 (1.14–1.58); retinoblastoma, 0.95 (0.68–1.32); rhabdomyosarcoma, 0.86 (0.61–1.20); embryonal, 0.97 (0.66–1.43); alveolar, 1.92 (0.43–8.51); and Wilms tumor, 1.01 (0.83–1.24). The ORs (95% CI) of high (>4000 g) versus normal birthweight and childhood cancers were as follows: leukemia, 1.30 (1.18–1.42); acute lymphoblastic leukemia, 1.27 (1.16–1.39); acute myeloid leukemia, 1.13 (0.98–1.30); lymphoma, 1.69 (0.72–3.94); Hodgkin, 1.22 (1.02–1.46); non-Hodgkin, 1.22 (0.80–1.86); neuroblastoma, 1.20 (1.02–1.41); retinoblastoma, 1.17 (0.93–1.48); rhabdomyosarcoma, 1.07 (0.90–1.27); embryonal, 1.22 (1.00–1.49); alveolar, 1.02 (0.46–2.27); and Wilms tumor, 1.49 (1.34–1.67).

Conclusion
This meta-analysis identified high birth weight as a potential risk factor for some childhood cancers, while low birth weight might be protective against a few.
Open Surgical Excision of Dorsal Wrist Ganglia: Puncturing the Dome Reduces Surgery Time
Authors: Al-Qattan Mohammad M. , Altwaijri Nouf A. , Al-Mohrij Saad A. , Al-Qattan Ahmed M. 
Published: June 2024

Background:
The following study is retrospective and compared the operative time and complications using two techniques of surgical resection of primary dorsal wrist ganglia in adults.

Methods:
Surgery was performed by the senior author (M.M.A.) through a transverse skin incision. The dome of the ganglion is dissected in both techniques. In the first technique (group A patients, n = 20 patients), dissection is continued to the base of the ganglion to reach the stalk near the scapho-lunate ligament. The stalk is transected and cauterized near the ligament. This surgical technique has been practiced by the senior author for 25 years. Over the last 5 years, the author has modified the technique (group B patients, n = 20 patients) by puncturing the dome of the ganglion following dome dissection. About two-thirds of the content of the ganglion is removed, and a mosquito is then used to close the puncture site. Dissection of the base of the ganglion to the stalk becomes easier and quicker, and the stalk is transected and cauterized near the scapho-lunate ligament.

Results:
There was one recurrence in each group. Other complications were not seen in either group. The mean operative time (SD) was 30.75 (SD = 2.98) minutes for group A; and 20.75 (SD = 2.25) minutes for group B. An independent-samples t test was used to compare the operative time of both groups, which showed the difference was statistically significant (P < 0.001).

Conclusions:
Our study showed that intentionally puncturing the dome of the ganglion makes the dissection of the base quicker, without increasing the risk of complications.
Lymphovenous Anastomosis for the External and Internal Types of Head and Neck Lymphedema: A Case Series and Preliminary Clinical Results
Authors: Lin Ying-Sheng , Liu Chia-Ju , Chou Chen-Han 
Published: June 2024

Background:
Head and neck lymphedema (HNL), including external and internal types, could be a possible consequence for patients who have received neck dissection and radiotherapy for head and neck cancer. Initially, the common presentations are heaviness or tightness, followed by swelling in appearance, or difficulty speaking and swallowing in internal edema cases. Lymphovenous anastomosis (LVA) is an established approach to treat extremity lymphedema. We hereby present our preliminary experience in using LVA to treat HNL.

Methods:
Between March 2021 and January 2024, six patients with HNL were treated with LVA via a preauricular or submandibular incision of the obstructed side. Lymphedema Symptom Intensity and Distress Surveys—Head and Neck (LSIDS-H&N) were used for evaluation. In addition, for the external type, MD Anderson Cancer Center Head and Neck Lymphedema (MDACC HNL) rating scale was used for evaluation. For the internal type, Swallowing Quality of Life was used for evaluation.

Results:
With an average follow-up period of 15.4 ± 15.9 months, LSIDS-H&N improved from 1.11 ± 0.54 to 0.44 ± 0.66 (P = 0.02). For patients with the external type, within an average follow-up period of 15 ± 16.1 months, the MDACC HNL rating scale improved from level 2 to 0 or 1a (P = 0.008). For patients with the internal type, within an average follow-up period of 21 ± 17.3 months, Swallowing Quality of Life improved from 130.5 ± 9.2 to 151 ± 19.8 (P = 0.5).

Conclusions:
Based on our preliminary results, LVA could be a potential solution to both external and internal HNL.
Nicotine aggravates liver fibrosis via α7 nicotinic acetylcholine receptor expressed on activated hepatic stellate cells in mice
Authors: Mihara Taiki , Hori Masatoshi 
Published: June 2024

Background:
Smoking is a risk factor for liver cirrhosis; however, the underlying mechanisms remain largely unexplored. The α7 nicotinic acetylcholine receptor (α7nAChR) has recently been detected in nonimmune cells possessing immunoregulatory functions. We aimed to verify whether nicotine promotes liver fibrosis via α7nAChR.

Methods:
We used osmotic pumps to administer nicotine and carbon tetrachloride to induce liver fibrosis in wild-type and α7nAChR-deficient mice. The severity of fibrosis was evaluated using Masson trichrome staining, hydroxyproline assays, and real-time PCR for profibrotic genes. Furthermore, we evaluated the cell proliferative capacity and COL1A1 mRNA expression in human HSCs line LX-2 and primary rat HSCs treated with nicotine and an α7nAChR antagonist, methyllycaconitine citrate.

Results:
Nicotine exacerbated carbon tetrachloride–induced liver fibrosis in mice (+42.4% in hydroxyproline assay). This effect of nicotine was abolished in α7nAChR-deficient mice, indicating nicotine promotes liver fibrosis via α7nAChR. To confirm the direct involvement of α7nAChRs in liver fibrosis, we investigated the effects of genetic suppression of α7nAChR expression on carbon tetrachloride–induced liver fibrosis without nicotine treatment. Profibrotic gene expression at 1.5 weeks was significantly suppressed in α7nAChR-deficient mice (−83.8% in Acta2, −80.6% in Col1a1, −66.8% in Tgfb1), and collagen content was decreased at 4 weeks (−22.3% in hydroxyproline assay). The in vitro analysis showed α7nAChR expression in activated but not in quiescent HSCs. Treatment of LX-2 cells with nicotine increased COL1A1 expression (+116%) and cell proliferation (+10.9%). These effects were attenuated by methyllycaconitine citrate, indicating the profibrotic effects of nicotine via α7nAChR.

Conclusions:
Nicotine aggravates liver fibrosis induced by other factors by activating α7nAChR on HSCs, thereby increasing their collagen-producing capacity. We suggest the profibrotic effect of nicotine is mediated through α7nAChRs.
Enhancing Cardiorespiratory Fitness Through Sauna Bathing
Authors: Kunutsor Setor K. , Isiozor Nzechukwu M. , Kurl Sudhir , Laukkanen Jari A. 
Published: June 2024

Purpose:
The physiological adaptations stimulated by a sauna bath (SB) are similar to those produced by moderate- or high-intensity physical activity (PA), but the relationship between SB and cardiorespiratory fitness (CRF) is not clear. The objective of this study was to evaluate the cross-sectional and longitudinal associations between frequency and duration of SB with CRF.

Methods:
Baseline SB habits were assessed in 2012 men aged 42 -61 yr. CRF was directly measured using a respiratory gas exchange analyzer during cardiopulmonary exercise testing at baseline and 11 yr later. The associations of SB frequency and duration with baseline and 11-yr levels of CRF were examined using robust regression analyses adjusted for several confounders, including lifestyle factors such as PA.

Results:
In baseline analysis, a unit increase in sauna sessions/wk was associated with an increase in CRF 0.30 mL/kg/min (standard error [SE]: 0.14; P = .034). Alternatively, compared with a single sauna sessions/wk, 2-3 and 4-7 sauna sessions/wk was each associated with significant increases in levels of CRF: 0.84 mL/kg/min (SE: 0.32; P = .008) and 1.17 mL/kg/min (SE: 0.57; P = .041), respectively. In longitudinal analysis, frequent SB was associated with increases in 11-yr CRF levels, but this was only significant for 2-3 sauna sessions/wk compared with a single sauna sessions/wk: 1.22 mL/kg/min (SE: 0.59; P = .038). Duration of SB was not significantly associated with CRF levels in cross-sectional and longitudinal analyses.

Conclusions:
Frequent SB may improve levels of CRF independently of PA. These results warrant replication in robust definitive randomized controlled trials.