bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Gamma‐Aminobutyric Acid on the Release of Prolactin, Luteinizing Hormone and Follicle Stimulating Hormone in Spayed Rats
Authors: Ohkawa Tomi , Sato Naoki , Okinaga Shoichi , Arai Kiyoshi 
Published: August 2010

AbstractThe effect of Gamma‐Aminobutyric Acid (GABA) on the release of Prolactin (PRL), Luteinizing Hormone (LH), and Follicle Stimulating Hormone (FSH) in spayed rats was studied. Adult female rats of the Wistar strain were ovariectomized 30 days prior to the experiments and various doses of GABA and/or picrotoxin (PCT) were injected into the third ventricle under Nembutal anesthesia. A dose of 10‐8 mole GABA produced a marked decrease in plasma PRL levels. On the other hand, the addition of 10‐8 mole PCT to 10‐8 mole GABA antagonized the inhibitory effect of GABA, whereby plasma PRL levels returned to pretreatment values. Plasma LH levels increased significantly after intraventricular administration of 10‐7 mole of GABA. FSH concentrations remained unchanged after the same treatment. Intraventricular injection of GABA interfered with central nervous system (CNS) function in the periventricular region and activated hypothalamic nerve cells. Participation of the hypothalamic inhibitory interneurons in inhibition of PRL release and the LH secretion stimulatory mechanism were discussed.
The Guinea Pig Hypothalamo‐Neurohypophyseal Complex in Organ Culture for Oxytocin Studies
Authors: Suzuki Hideaki , Makino Tsunehisa , Haginiwa Ichigen , Iizuka Rihachi 
Published: August 2010

AbstractThe guinea pig hypothalamo‐neurohypophyseal complex (HNC) was assessed as a possible in vitro model for oxytocin (OT) studies. The hypothalamus was incised in such a way as to contain intact supraoptic and paraventricular nuclei. The HNC was maintained for a week on a steel grid in Eagle's Minimum Essential culture medium (containing 10% fetal bovine serum and kanamycin 60 mg/1, pH 7.0) and incubated at 37°C under 95% air and 5% CO2. OT released from the HNC into the culture medium in a 20 minute period was measured every day. OT concentrations were fairly constant from Day 1 to Day 7 in culture.The hypothalamus and the pituitary were also incubated in the same conditions as the HNC in culture for comparison. Our studies indicate that OT was released from the HNC in constant quantities.Histological observations under light microscopy showed that the neurosecretory cells remained viable during the culture period.We believe organ culture of the HNC could be a useful model for further OT studies.
C‐Reactive Protein in EPH Gestosis
Authors: Nayel Sayed A. , Kandil Kamal K. , Mustafa Essam M. Abu 
Published: August 2010

AbstractC‐reactive protein (C R P) was measured in thirteen normal non pregnants, thirty four normal gravidas, and seventeen cases of EPH gestosis. No significant differences were found between the normal non pregnants and the normal pregnants. It was found to be significantly higher in EPH gestosis than in the other two groups.
Total Platelet Count, Adhesive Platelet Count, Platelet Adhesiveness in Normal Menstrual Cycle and Functional Uterine Bleeding: A Comparative Study
Authors: Abbott R. , Chandra M. , Chandra R. 
Published: August 2010

AbstractThe menstrual cycle is known to influence the haemodynamic and the thrombocytic elements in women.All 100 cases in this study were investigated to exclude any bleeding disorder or severe anaemia.In a control group of 50 women, with normal and regular menstrual cycle it was observed that the total platelet count (TPC) and adhesive platelet count (APC) increased gradually to a peak from menstrual to the mid cycle phase and subsequently declined to an intermediate level in the premenstrual phase. Platelet adhesiveness (PA) showed negligible change.In other 50 cases of FUB (Group A: 25 cases of FUB with menorrhagia; Group B: 25 cases of FUB with continuous irregular bleeding), the mean values of TPC and APC were consistently lower but a phasis trend was maintained similar to control cases. However, PA was consistently elevated and declined only during the mid cycle. The above changes in FUB seem to be due to:(a) reduced absorption of necrotic material into circulation(b) deranged hormonal levels‐,(c) acceleration of thrombin formation
The Establishment of Human Choriocarcinoma Cell Line in Vitro
Authors: Suzumori Kenji , Sugimoto Yoshie , Suzjmori Kaoru , Yagami Yoshiaki , Takeda Akihiro 
Published: August 2010

AbstractA new tissue culture cell line, designated NUC‐1, has been established from human choriocarcinoma of the uterus. The cell line has now been growing in vitro for 28 months and has been subcultured 32 times. The cell grew in a monolayer sheet, showed a marked tendency to pile up, and released human chorionic gonadotropin (hCG) in media. During logarithmic growth in vitro, the doubling time for NUC‐1 was 36 hr. Light and electron microscopic observation showed that the cultured cells consist of various types of trophoblastic cells ranging from cytotrophoblasts to syncytiotrophoblasts. The chromosomal constitution of this cell line was hyperdiploid, and the marker chromosome could be identified in the A‐group. Cultured cells at the seventh passage were transplanted to nude mice; histological examination of the tumor which developed in nude mice showed close resemblance to the original tumor.
Effect of Ritodrine Hydrochloride on Uterine Activity and Maternal and Fetal Circulations in the Pregnant Sheep
Authors: Fujimoto Seiichiro , Akahane Masuo , Uzuki Katsuya , Inagawa Akira , Sakai Keiichiro , Ichinoe Kihyoe 
Published: August 2010

AbstractThe effects of ritodrine hydrochloride on uterine activity and maternal and fetal circulations were investigated in chronically prepared pregnant sheep. Ritodrine inhibited oxytocin‐induced uterine contractions in a dose‐dependent manner. The inhibition of uterine activity at 3 mcg/kg/min of ritodrine was about 70%, and greater infusion rates resulted in only minimal further inhibition of the uterine activity. Maternal tachycardia but no hypotension were observed during ritodrine infusion. There were no significant changes in fetal heart rate or blood pressure. Uterine arterial blood flow decreased remarkably at higher doses of ritodrine. These changes were, however, less pronounced when ritodrine was infused at a constant dose of 3 mcg/kg/min, which was sufficient to inhibit the uterine activity.In addition, propranolol blocked the effect of ritodrine on uterine activity and maternal heart rate. This supports the view that ritodrine produces its effects through activation of adrenergic β‐receptor.
Management of Hydatidiform Mole in Women over 45 Years Old*
Authors: Soma Hiroaki , Takayama Masaomi , Saito Toshiki , Isaka Keiichi 
Published: August 2010

AbstractIn order to estimate the incidence of hydatidiform mole in older women, the records of 369 cases of hydatidiform mole including 27 patients over 45 years of age were investigated and compared with total numbers and distributions of 4964 pregnancies by maternal age during a 6‐year period (1975 – 1980) at Tokyo Medical College Hospital.The incidence of hydatidiform mole in women over 45 years of age was extremely high, in spite of the low rate of pregnancy for that age. The increase was 45‐fold in such older patients. Eighteen of 27 cases over 45 years of age developed subsequently into malignant changes. The rate of such malignant progressions as choriocarcinoma or invasive mole was 66% in women over the age of 45 as compared with around 15% in those under 44 years of age. Thus, women aged 45 years or more are subject to a 4.4‐fold increase in the risk of choriocarcinoma or invasive mole.
Pregnancy Gingivitis and Estimation of Oxygen Consumption in Gingival Tissue
Authors: Saleh F.M. , Abd‐El‐Gawad A.H. , Ragheb A. , Nour Z.M. , El‐Negoumi I.A. , El‐Bassyouni A.M. 
Published: August 2010

AbstractForty females were included for the clinical dental examination and estimation of oxygen consumption in the gingival tissue using the Warburg manometrictechnique. In the twenty pregnant females there were no significant difference in the plaque and retention indices as compared to the non‐pregnant females. However the gingival index was significantly higher in pregnant women. The oxygen consumption in the gingival tissue showed a statistically significant increase in the pregnant women. Explanation for these changes were discussed.
On‐line Computer System for Storage and Retrieval of Perinatal Records
Authors: Kitazoe Yasuhiro , Yamamoto Koji , Hashimoto Hiroshi , Ogura Hisakazu , Furutani Hiroshi , Takeda Yoshihiko 
Published: August 2010

AbstractAn on‐line computer system for easy entry and retrieval of perinatal records is described. Using this on‐line system, physicians without any knowledge of computer language can make simple statistical calculations. Originally developed as a data entry system for perinatal records gathered by the Committee on Perinatal Statistics of the Japan Society of Obstetrics and Gynecology, this system was then merged into IMIS, the Integrated Medical Information System of Kochi Medical School. 448 cases of perinatal deaths were registered by the end of 1982. Using these death cases, dependence of main clinical causes of death on gestational week and birth weight is shown as an example of the results obtained using this computer system.
Relation of the Site of Congenital Upper Gastrointestinal Obstruction to Amniotic Fluid Bilirubin Concentration
Authors: Hisanaga Sachio , Shimokawa Hiroshi , Kurokawa Tatsuro , Maesato Soei , Nakano Hitoo 
Published: August 2010

AbstractIn order to ascertain relative amniotic fluid bilirubin concentrations and to assess their value in antenatal diagnosis of upper gastrointestinal obstruction, amniotic fluid samples obtained from eight women who gave birth to infants with congenital upper gastrointestinal obstruction were analyzed spectrophotometrically.Types of congenital upper gastrointestinal obstruction in the study included esophageal atresia (1), pyloric atresia (1), high jejunal atresia (1), annular pancreas (2), and duodenal atresia (3).Amniotic fluid bilirubin concentration of the six women who gave birth to infants with intestinal obstruction distal to Vater's ampulla increased above the mean + 2 S.D. of the control. By contrast, the two who gave birth to infants with esophageal atresia or pyloric atresia had normal levels of amniotic fluid bilirubin.These findings suggest that when the obstruction is distal to Vater's ampulla, bile is regurgitated into the amniotic fluid by the fetus, resulting in a significant increase in amniotic bilirubin concentration. However, amniotic fluid bilirubin doesn't originate from the upper gastrointestinal tract in normal pregnancies: its concentration was within the normal range in the two fetuses with esophageal or pyloric atresia who couldn't regurgitate bile into the amniotic fluid.
Effects of Domperidone on Serum Prolactin Levels in Rats with Hypothalamic Deafferentation
Authors: Kato Hiroshi , Ueda Kazuyuki , Tamura Haruyo , Fujino Toshio , Toyoshima Hiroyuki , Hiratsuka Keisuke , Mano Takafumi , Torigoe Tadashi 
Published: August 2010

AbstractThe sites of action of domperidone, a dopamine antagonist, in stimulating prolactin secretion were studied in female rats subjected to one of the following treatments: Hypophysectomy and pituitary‐autotransplantation beneath the kidney capsule; hypothalamic deafferentation at the medial hypothalamus between the anterior hypothalamic area and the nucleus dorso‐medialis hypothalami (MHD); hypothalamic deafferentation in the posterior part of the hypothalamus just caudal of the nucleus mamillaris (PHD); MHD plus PHD. In the hypophysectomized pituitary‐auto‐transplanted rats, intravenous injections of domperidone (200 μg/100 g body weight) neither increased serum prolactin levels nor reversed the inhibition caused by bromocriptine. On the other hand, domperidone caused significant increases in serum prolactin levels in all groups of rats with hypothalamic deafferentation. These results indicated that domperidone, at least at high concentrations, acts through the caudal part of the hypothalamus to stimulate prolactin secretion.
Pivmecillinam in Treatment of Complicated Urinary Tract Infections during Initial Prophylactic Therapy after Radical Hysterectomy
Authors: Tamaya Teruhiko , Tsurusaki Toshihide , Kusanishi Hiroshi , Okada Hiroji 
Published: August 2010

AbstractThe clinical efficacy of pivmecillinam was evaluated in the treatment of complicated urinary tract infections occurring during prophylactic initial therapy immediately after radical hysterectomy with pelvic lymphadenectomy in 29 patients with uterine cervical cancer. Pivmecillinam was administered 400mg daily for 2 weeks. Overall clinical evaluation was done in 24 cases. The result was excellent in 5, good in 10, and a failure in 9 cases, for an overall efficacy rate of 62.5%, based on the assessments of pyuria and bacteriuria. Side effects in patients who received pivmecillinam were not remarkable.Pivmecillinam appears to be useful for maintenance therapy against complicated urinary tract infection in gynecology. Clinical considerations concerning the bacteriological findings are also discussed.
Evaluation of Male Infertility by Penetrability (or Penetration Assay) of the Human Spermatozoa through Zona‐Free Hamster Ova
Authors: Tang Lawrence C. H. , Chan Steven Y. W. , Ma Ho‐kei 
Published: August 2010

AbstractThe human spermatozoa zona‐free hamster ova penetration assay (SPA) and seminal fluid analysis (SFA) were performed on 44 infertile and 35 fertile couples. The mean penetration rate for semen samples from fertile males (44% ± 3%) was significantly higher (p<0.05) than that of semen samples from infertile males (10% ± 1%). Penetration rates below 20% were not observed with fertile semen samples. No correlation (p>0.05) was observed between the spermatozoal density, total spermatozoal count, percentage of motile spermatozoa, or percentage of normal morphology and the penetration rate. The sensitivity of the SPA was 91% and the specificity was 100% as compared to 73% and 83% respectively for the SFA. These findings indicate that the SPA is useful in the assessment of the fertility potential of human semen samples in the evaluation of male fertility and infertility.
Uterine Contractile Effect of an Oxytocin‐like Substance in the Human Placenta
Authors: Nakazawa Kazumi , Makino Tsunehisa , Nagai Takashi , Lizuka Rihachi , Lshii Kunio 
Published: August 2010

AbstractsThe bioactivity of an oxytocin‐like substance in human term placental tissue was examined using rat uterine muscle obtained during diestrus.The human term placental tissue extract contracted the rat uterine muscle on a Magnus apparatus. Placental tissue extract incubated with oxytocin antiserum did not induce significant contraction of the muscle, whereas placental tissue extract incubated with normal rabbit serum induced a significant effect on the rat uterine muscle. Synthetic oxytocin caused contraction similar to that caused by placental tissue extract in rat uterine muscle. This contraction was also inhibited when synthetic oxytocin was incubated with anti‐oxytocin serum for 24 hr at 4°. Normal rabbit serum and anti‐oxytocin serum alone did not cause contraction. These results suggest that the oxytocin‐like substance in the human placenta may possess uterine contractile activity.
Surgical Induction of Labour
Authors: Wong P. C. , Ratnam S. S. 
Published: August 2010

SummarySix hundred and forty‐one patients who underwent induced labour over a 12 month period were analysed. The ethnic group distribution was similar to that in the obstetric population. 54.6% of these were primiparous patients. The common indications of induced labour were hypertensive disorder of pregnancy, static weight and post‐term pregnancy. The mean induction delivery interval was 8.52 hours in primiparous and 5.18 hours in multi‐parous patients. The caesarean section rate was 15% and this was statistically more than those with spontaneous labour. The rate of complication was very low.
The Effect of Electro‐cutting and Diathermy Coagulation on Wound Healing in Gynecological Surgery
Authors: Nayel Sayed A. , Habashy Mostaf A. El , Osman Ahmed M. , Gawad Aly A. 
Published: August 2010

AbstractThirty patients were enrolled in this study. In half of the group, electrocutting was used in transecting the abdomen, while in other half, the conventional scalpel was used. From our observations; diathermy incisions showed some impairment of the healing, but no serious complications has occurred. The observation of the wound healing and complications of the procedures used were discussed in the light of the available data.
Clinical Significance of Antithrombin III, Plasminogen and Alpha2‐plasmin Inhibitor in Perinatal Period
Authors: Fuse Yoji , Fuse Kozue 
Published: August 2010

AbstractWe studied changes in antithrombin III, plasminogen and alpha2‐plasmin inhibitor levels in the maternal and cord blood by a newly developed fluorescent substrate assay method. Correlations between bleeding on parturition and weight of the newborn were also studied.No marked changes in antighrombin III, plasminogen and alpha2 ‐plasmin inhibitor levels were noted before or after parturition in either the normal bleeding or the abnormal bleeding group, but preparturient plasminogen and alpha2‐plasmin inhibitor values correlated with amount of bleeding on parturition, and could therefore be used to predict intrapartal bleeding.The SGA (small for gestational age) group showed a significant decrease of plasminogen and alpha2‐plasmin inhibitor compared with the AGA (appropriate for gestational age) and LGA (large for gestational age) group, which was understood to be due to mild acidosis caused by stress in pregnancy and on parturition and immaturity of the neonatal liver.
Some Characteristics of Breech Deliveries
Authors: Wong P.C. , Widjaya Kusuma , Heng S.H. , Ratnam S.S. 
Published: August 2010

AbstractTwo hundred and forty‐four patients with breech presentation occurring in a one year period of a total of 7676 deliveries were analysed. The incidence of breech deliveries was 3.2%. 57.4% of breeches occurred in primiparous patients and a quarter of them were delivered premature. 80% went into spontaneous labour whilst a third were delivered abdominally. 10.2% of the babies were less than 2270 g. The overall perinatal mortality rate of breeches over 1000 g was 55 per 1000. Some of the factors affecting the perinatal mortality were discussed.
The Management of Female Hirsutism with the Anti‐Androgen Agent Cyproterone
Authors: Kwok Peter C. , Correy Joseph F. , Senator Gordon B. 
Published: August 2010

AbstractThe treatment of female hirsutism with a combination of the anti‐androgen agent Cyproterone Acetate and Ethinyl Oestradiol is discussed in 53 patients of whom 37 have completed 12 months' treatment. Assessment was carried out by serial scoring using the Ferriman and Gallwey method. The majority of patients experienced satisfactory subjective improvement, and objective improvement was recorded in approximately half of the patients who completed the full course of 12 months' treatment. Side effects of treatment were experienced by 27 of the 37 patients completing 12 months' treatment but in most instances were mild and related to the oestrogen. Minimal disturbances of liver function tests and lipids were noted which did not reach significance. The maximum response to treatment was noted after 6 months of therapy, and it is recommended that this be the standard initial course of treatment.
Duplication of Ileum in Fetus: A Case Report
Authors: K‐ozuka Mitsuo , Sato Akira , Tanigawara Shingo , Suzuki Toshiaki , Kimura Kazuhiko 
Published: August 2010

AbstractFetal abdominal c‐st different from the urinar‐ bladder was detected b‐ real‐time ultrasonograph‐.The c‐st, which had grown to approximatel‐ 60 mm in diameter at the 29th week of gestation, was punctured under real‐time ultrasonographic guidance. Fetograph‐ revealed no distinctive external malformation.Examination of the fluid from the c‐st did not reveal the c‐st̂s origin.Laparotom‐ conducted on the 19th da‐ after birth revealed duplication of the ileum at approximatel‐ 95 cm from the end of ileum.Indications for intra‐uterine treatment are discussed.
Postoperative Arterial Thrombosis
Authors: Pal S. K. , Chowdhur‐ N. N. Ro‐ 
Published: August 2010

AbstractArterial thrombosis following pelvic surger‐ is a rare phenomenon. In the present communication unilateral thrombosis of common iliac and external iliac arter‐ is reported in the postoperative period in a case of carcinoma cervix who had bilateral internal iliac arter‐ ligation done, as an emergenc‐ procedure to control vaginal bleeding. Patient developed evidence of arterial obstruction of right leg on third postoperative da‐ and the level of obstruction was determined b‐ doppler ultrasonic velocit‐ detector. Right external arteriotom‐ was done and thrombi were removed b‐ Fogart‐ balloon catheter. Unfortunatel‐ patient died of postoperative shock.It is highl‐ probable that thrombosis superimposed on a preexisting atheromatous patch in the iliac vessel. The exiciting factors in the present case were slowing of circulation which occurred during the last bout of vaginal haemorrhage and also handling of the arteries during the operation which might have initiated arterial spasm thus favouring thrombus formation.
Collaborative Stud‐ on Preterm Breeches: Vaginal Deliver‐ Versus Caesarean Section
Authors: Viegas Osborn A. C. , Ingemarsson Ingemar , Sim Low Poh , Singh Kuldip , Cheng Mark , Ratnam S. S. , Chow K. K. , Ho T. H. , Vengadasalam D. 
Published: August 2010

SummaryPerinatal outcome and infant development in 73 preterm breech deliveries is described in relation to mode of deliver‐.32 such cases were delivered b‐ caesarean section and 41 b‐ the vaginal route between April 1982 and December 1983 at the 5 major government deliver‐ units in Singapore ‐ all with comparable neonatal services.Vaginal deliver‐ was associated with a higher intrapartum and neonatal mortalit‐ and morbidit‐ when compared with infants delivered b‐ caesarean section (mortalit‐ rate in vaginal deliver‐ group = 17.1% compared with 6.3% in caesarean section group). Furthermore, amongst the 25 children assessed at 12 months of age, there was a tendenc‐ to better performance in gross motor function and language abilit‐ in those delivered abdominall‐. The present results suggest that the preterm breech might benefit from caesarean section even if variables other than the mode of deliver‐ influence the outcome. These findings are consistent with previous reports which have also been briefl‐ reviewed.However, the higher maternal morbidit‐ associated with caesarean deliver‐ and the risk for unnecessar‐ surgical intervention (eg in cases of malformed fetuses) make a careful preoperative assessment imperative.
Recurrence of Invasive Moles and Choriocarcinomas
Authors: Hirokawa Kiyoji , Tomoda Yutaka , Kaseki Shigeaki , Ishizuka Takao , Nishikawa Yoshiki , Goto Setsuko 
Published: August 2010

AbstractPrevention of the recurrence is the most important issue to be considered for improving the results of treatment of trophoblastic disease. The authors strictly differentiated choriocarcinoma and invasive mole and studied problems related to their recurrence. There were 17 recurrent cases out of 320 invasive moles treated until 1979. Among them histologically confirmed cases were all found to be choriocarcinoma at the time of recurrence. By applying strict criteria for judgement of complete remission, a drop of 7.7 — 1.8% in the recurrence rate was achieved.Regarding 159 choriocarcinoma cases treated until 1979, the remission rate was remarkably improved, but decrease in the recurrence rate could not be achieved. The risk factors involved in the recurrence of the disease were investigated, and factors such as history of hydatidiform mole, tumor localization, alteration of platelet count, and number of chemotherapeutic courses needed after hCG dropped to minimum level were found to be related. Since 1980, observance of the risk factors and improved treatment regimen has decreased the recurrence rate of choriocarcinoma.