bluuebunny/crossref_metadata_2025_split huggingface dataset:
An improved noise model of InP HEMT for millimeter wave application
Authors: Li Zhichun , Lv Yuanting , Zhang Ao , Gao Jianjun 
Published: May 2024

AbstractA new temperature noise model, including the influence of gate‐drain series resistance Rgd on the noise performance for an InP HEMT, is presented in this article. An equivalent temperature Tgd of Rgd has been taken into account based on Pospieszalski's noise model. The corresponding extraction procedure of noise parameters is given. Good correlation between the simulated and measured noise parameters in the frequency range of 8–50 GHz for a wide range of bias points verify the validity of the improved noise model.
The pH effects on thermal amyloid fibrillation kinetics of hen egg‐white lysozyme using new normalization factor for Raman spectroscopy
Authors: Liu Dongxiao , Chen Ning , Zhang Tianle , Zhou Xiaoguo , Liu Shilin 
Published: May 2024

AbstractAmyloid fibrillation kinetics of proteins associated with neurodegenerative diseases has been extensively studied using Raman spectroscopy. The normalization factor for the spectra is crucial for obtaining correct kinetics of Raman indicators, especially vibrational band intensities. Here, we compared the concentration dependences between the absorption at 280 nm in UV–vis spectroscopy and the phenylalanine (Phe) Raman band intensity at 1003 cm−1 in amyloid fibrillation kinetics of lysozyme. The former exhibits better performance as normalization factor. Using this new normalization factor, the effect of pH value on the transformation of hen egg‐white lysozyme (HEWL) tertiary and secondary structures was studied subsequently. With increasing acidity, the unfolding of tertiary structures and the transformation of secondary structures are significantly accelerated. Notably, the populations of various secondary structures in the final state remain in the pH < 2.0 solutions, indicating that the branching ratios of “on‐pathway” to amyloid fibrils and “off‐pathway” to gel‐like aggregates are independent on the pH value in the range of 1.1–1.9.
Arthroscopic repair is an effective treatment for dynamic medial ankle instability secondary to posttraumatic and partial injury of the deltoid ligament deep fascicle
Authors: Vega Jordi , Malagelada Francesc , Guelfi Matteo , Dalmau‐Pastor Miki 
Published: May 2024

AbstractPurposeWhen the intermediate or collicular fascicle of the medial collateral ligament (MCL) is injured, the diagnosis of posttraumatic medial ankle instability (MAI) is supported. The aim of this study was to describe an arthroscopic all‐inside MCL repair after posttraumatic MAI secondary to an isolated injury of the MCL deep fascicle with a knotless suture anchor technique.MethodsSeven patients (seven men, median age: 23 [19–28] years) with posttraumatic MAI were treated by arthroscopic means after failing nonoperative management. The median follow‐up was 34 (13–75) months. The MCL was repaired with an arthroscopic all‐inside technique.ResultsA tear affecting the deep and intermediate or collicular fascicle of the MCL was observed in all cases. In addition, five patients were diagnosed with an isolated fibular anterior talofibular ligament (ATFL) detachment, and in two patients, both the ATFL and calcaneofibular ligament were involved. All patients reported subjective improvement after the arthroscopic ligament repair. The median American Orthopedic Foot and Ankle Society score increased from 68 (range: 64–70) preoperatively to 100 (range: 90–100) at final follow‐up.ConclusionPosttraumatic MAI can be successfully treated by an arthroscopic all‐inside repair of the MCL. The presence of an MCL tear affecting the tibiotalar ligament fibres attached to the area of the anterior colliculus should be considered a sign of posttraumatic MAI. This partial deltoid injury at the level of the intermediate or collicular fascicle will conduct to a dynamic MAI.Level of EvidenceLevel IV.
Chimeric versus Multiple Flaps for Composite Oral Cavity Defects: A Systematic Review and Meta‐Analysis
Authors: Punjabi Ayesha , Araya Sthefano , Amadio Grace , Webster Theresa , Mutyala Sudeep , Wu Meagan , Zhao Huaquing , Roth Stephanie , Walchak Adam , Patel Sameer A. 
Published: May 2024

ObjectivesComplex head and neck defects involving composite defects can be reconstructed using chimeric flaps or multiple flaps with separate anastomoses. Limited comparisons exist between chimeric and multiple flap reconstructions. We compare outcomes between chimeric and multiple flap reconstructions in oral cavity reconstruction.Data SourcesPubMed (NLM), Embase (Elsevier), Web of Science (Clarivate Analytics), and Cochrane CENTRAL (Wiley).MethodsA systematic review was conducted, including English articles reporting outcomes of oral cavity reconstruction with either chimeric flaps or multiple flaps. Data extraction included patient characteristics, flap type, and outcomes such as flap survival, partial flap loss, operating room time, hospital length of stay, and postoperative complications.ResultsForty‐seven articles comprising 1435 patients were included. Notably, 552 patients underwent multiple flaps, while 883 received chimeric flaps. Meta‐analysis revealed no statistically significant difference in flap survival between chimeric and multiple flap patients (98% vs. 99%, p = 0.198). Multiple flap patients had higher rates of operating room take‐backs for anastomotic issues and longer hospital stays compared with chimeric flap patients. There were no significant differences in partial flap failure, resumption of diet and speech, need for subsequent flaps, fistula formation, or general complications.ConclusionThis large‐scale meta‐analysis demonstrates equivalent flap survival between chimeric and multiple flaps in the reconstruction of composite oral cavity defects. Both approaches appear to be safe and acceptable, with comparable outcomes in terms of diet and speech resumption, rates of fistulization, and general postoperative complications. Multiple flap patients had higher rates of operating room take‐backs and longer hospital stays.Level of EvidenceNA Laryngoscope, 134:4196–4202, 2024
Development and Initial Validation of a Meniere's Disease Quality of Life Instrument: The MenQOL
Authors: Quimby Alexandra E. , Brant Jason A. , Staab Jeffrey P. , Ruckenstein Michael J. 
Published: May 2024

ObjectiveTo design and validate a disease‐specific quality of life instrument for Meniere's disease.MethodsWe used a sequential process of expert input, patient focus groups, and analyses of responses to draft questionnaires to create a 24‐item Meniere's disease quality of life (MenQOL) instrument. The MenQOL and the SF‐36v2 were administered to a cohort of 50 patients with Meniere's disease and 60 comparison patients with tinnitus, vertigo, or hearing loss from other causes identified at a tertiary academic center. We performed exploratory factor analysis, Cronbach's α, between group comparisons of total MenQOL scores, and regression analyses between the MenQOL and SF‐36v2 to evaluate the instrument's factor structure, internal consistency, face validity, and external validity. Segregation of the instrument into domains was assessed by exploratory factor analysis.ResultsExploratory factor analysis revealed that the MenQOL has a single domain. Cronbach's α = 0.914 indicated high internal consistency for the instrument as a whole. Mean MenQOL scores showing significantly worse quality of life among patients with Meniere's disease than comparison participants (52.5 ± 15.8 vs. 43.2 ± 12.6; p = 0.0051), indicating good construct validity. Significant inverse relationships in bivariate linear regressions between total MenQOL scores and SF‐36v2 physical (slope = −0.94, p < 0.0001) and mental (slope = −1.16, p < 0.0001) composite scores showed acceptable concurrent validity.ConclusionsWe have described the initial development of the MenQOL, a simple, valid patient‐reported outcome measure that, subject to further study, may be used to assess the effects of treatment on disease‐specific quality of life in patients with Meniere's disease.Level of Evidence3 Laryngoscope, 134:4351–4357, 2024
Ultrasensitive DNA Origami Plasmon Sensor for Accurate Detection in Circulating Tumor DNAs
Authors: Chen Zhi , Meng Changle , Wang Xueliang , Chen Jiajie , Deng Jiefeng , Fan Taojian , Wang Lude , Lin Huiling , Huang Hao , Li Shuang , Sun Shuo , Qu Junle , Fan Dianyuan , Zhang Xueji , Liu Yingxia , Shao Yonghong , Zhang Han 
Published: May 2024

AbstractEarly lung cancer screening by computed tomography is hampered by pulmonary nodules caused by massive COVID‐19 infections, necessitating an ultrasensitive approach for the early diagnosis of lung cancers at the single‐base level from circular tumor DNAs (ctDNAs). This study introduces an approach that merges DNA origami and DNA scissors technologies in a framework of surface plasmon resonance (SPR) biosensors. By combining the precision of DNA origami probes with the inherent single‐base resolution of DNA scissors, this method systematically addresses the limitations of conventional SPR techniques, resulting in enhanced detection accuracy. The synergistic interplay between DNA scissors and DNA origami enables the SPR biosensors to achieve unprecedented levels of sensitivity, precision, and practical utility. This efficacy allows the precise identification of mutations, demonstrated here by detection of the T790M mutation in the EGFR gene and the G12C mutation in the KRAS gene of non‐small cell lung cancer patients. With this technique, single‐base resolution as well as near zeptomolar‐level sensitivity is achieved. As a result, this discovery holds significant potential to advance the field of precision diagnostics.
Ethylene homo and co‐polymerization catalyzed by extensively bulky nickel catalysts with shielding wings of chlorine atoms
Authors: Ahmad Naseer , Wang Wenbing , Tian Wanlu , Li Chao , Qasim Muhammad 
Published: May 2024

AbstractDesigning the catalysts to get high molecular weight polyethylene is an art. The catalysts bearing imine functionality derived from 8‐arylnaphthyl amines are more impressive and attractive in this regard. In this work, we synthesize 2,4‐dibenzhydryl‐8‐(3,5‐dichlorophenyl)naphthalen‐1‐amine to condense with picolinaldehyde, pyridine‐N‐oxide‐2‐carbaldehyde and 3,4‐dibutanone and then subsequently the treatment of resulting ligands with nickel precursors to get the corresponding catalysts. It was hypothesized that 3,5‐dichlorophenyl having extended wings of chlorine atoms along with bulky dibenzhydryl groups can provide good shielding on both apical positions of metal in response to slow down the chain transfer. More interestingly, the polymerization was done in industrially claimed n‐heptane solvent. All the catalysts showed activity in an order of 106, whereas a value of 1.04 × 107 g mol−1 h−1 has been recorded from keto‐imine based Ni‐3 catalyst. All catalysts generates polymer with high molecular weight with maximum value was recorded by Ni‐2 up to 37.4 × 104 g mol−1. Ni‐3 can also incorporate methyl 10‐undecenoate up to 2.6% in polyethylene backbone.
Asymmetric Synthesis of Dihydropyrimidinethione Podand in the Presence of C2‐Symmetric Bis(Hydroxy)Proline‐Containing Amides
Authors: Filatova Elena S. , Fedorova Olga V. , Ovchinnikova Irina G. , Kochetkov Sergei V. , Chistiakov Konstantin A. , Rusinov Gennady L. 
Published: May 2024

AbstractA stereoselective Biginelli reaction involving a CH‐active podand, thiourea, and benzaldehyde was carried out using C2‐symmetric bis(hydroxy)proline‐containing amides as chiral inducers. The target dihydropyrimidinethione‐containing podand was obtained with an enantiomeric excess of 65–75 % and a yield of 58 % under mild conditions. It was established that in the process of asymmetric induction the value of ee depended on the presence of OH group in the proline fragment and of the linker structure in the chiral inducer molecule, in particular, on the presence of asymmetric carbon atoms and the movability of the single bond between them in the linker itself. Based on experimental data, one of the probable reaction mechanisms confirming the special role of the L‐proline or trans‐4‐hydroxyproline fragments in asymmetric induction has been proposed. The developed technique for obtaining an active tuberculostatic agent expands the possibilities for using C2‐symmetric chiral inducers in asymmetric catalysis and is of interest for the synthesis of enantiomerically pure compounds of similar structure.
Tidal resonances for fuzzballs
Authors: Di Russo Giorgio , Fucito Francesco , Morales Jose Francisco 
Published: May 2024

Abstract
We study the gravitational tidal response of D1D5, Top Star and (1,0,n) strata horizonless geometries. We find that the tidal interactions in fuzzball geometries, unlike in the case of black holes, exhibits a sequence of resonant peaks associated to the existence of metastable bound states. The spectrum of resonant frequencies is computed by semianalytical and numerical methods.
Mosquito Microbiomes of Rwanda: Characterizing Mosquito Host and Microbial Communities in the Land of a Thousand Hills
Authors: Tokash-Peters Amanda G. , Niyonzima Jean Damascene , Kayirangwa Mirielle , Muhayimana Simon , Tokash Ivan W. , Jabon Jaimy D. , Lopez Sergio G. , Kearns Patrick J. , Woodhams Douglas C. 
Published: May 2024

AbstractMosquitoes are a complex nuisance around the world and tropical countries bear the brunt of the burden of mosquito-borne diseases. Rwanda has had success in reducing malaria and some arboviral diseases over the last few years, but still faces challenges to elimination. By building our understanding of in situ mosquito communities in Rwanda at a disturbed, human-occupied site and at a natural, preserved site, we can build our understanding of natural mosquito microbiomes toward the goal of implementing novel microbial control methods. Here, we examined the composition of collected mosquitoes and their microbiomes at two diverse sites using Cytochrome c Oxidase I sequencing and 16S V4 high-throughput sequencing. The majority (36 of 40 species) of mosquitoes captured and characterized in this study are the first-known record of their species for Rwanda but have been characterized in other nations in East Africa. We found significant differences among mosquito genera and among species, but not between mosquito sexes or catch method. Bacteria of interest for arbovirus control, Asaia, Serratia, and Wolbachia, were found in abundance at both sites and varied greatly by species.
Association between kidney stones and life's essential 8: a population-based study
Authors: Du Yuan-Zhuo , Guo Biao , Hu Hong-Ji , Dong Qian-Xi , Li Yi-He , Zhang Ji , Li Fu-Chun , Guo Ju 
Published: May 2024

Abstract
Background
Kidney stones exhibit a robust correlation with cardiovascular disease (CVD). The objective of this research is to investigate the correlation between kidney stones and Life's Essential 8 (LE8), a newly updated assessment of cardiovascular health (CVH), among adults in the United States.

Methods
In this study, which analyzed data from the 2007–2018 National Health and Nutrition Examination Survey, we employed LE8 scores (ranging from 0 to 100) as the independent variable, classifying them into low, moderate, and high CVH categories. The research examined the relationship between LE8 scores and kidney stones by using multivariate logistic regression and restricted cubic spline models, with kidney stones as the dependent variable.

Results
Out of the 14,117 participants in this research, the weighted mean LE8 score was 69.70 ± 0.27. After accounting for confounding factors, there was an inverse association between higher LE8 scores and the likelihood of developing kidney stones (OR of 0.81 per 10-point increase, with a 95% confidence interval of 0.77–0.85), demonstrating a non-linear dose–response pattern. Similar patterns were observed for health behaviors, health factor scores, and kidney stones. Stratified analyses demonstrated a stable negative correlation between LE8 scores and kidney stones across different subgroups.

Conclusion
LE8 and its subscale scores exhibited a robust and inverse correlation with the occurrence of kidney stones. Encouraging adherence to optimal CVH levels has the potential to serve as an effective strategy in preventing and minimizing the occurrence of kidney stones.
Komplementinhibitorentherapie bei geographischer Atrophie (GA): funktionelle und morphologische Wirksamkeit und relevante Biomarker in der klinischen Praxis
Authors: Schmidt-Erfurth Ursula , Riedl Sophie 
Published: May 2024

ZusammenfassungDie Zulassung komplementinhibitorischer Therapeutika zur Behandlung der geographischen Atrophie (GA) macht die verlässliche und reproduzierbare Messung von Krankheitsfortschreiten und Therapieerfolg unerlässlich. Die optische Kohärenztomographie (OCT) ist aufgrund ihrer Verbreitung und Bildgebungscharakteristiken die Methode der Wahl. Anhand artificial intelligence (AI)-basierter OCT-Analyse konnte die therapeutische Wirksamkeit von Pegcetacoplan auf retinaler Pigmentepithel(RPE)- und Photorezeptor(PR)-Ebene nachgewiesen werden. Cloud-basierte Lösungen, die das GA-Monitoring ermöglichen, stehen bereits zur Verfügung.
Disentangling Ecosystem Necromass Dynamics for Biodiversity Conservation
Authors: Barton Philip S. , Schultz Nick , Butterworth Nathan J. , Ulyshen Michael D. , Mateo-Tomás Patricia , Newsome Thomas M. 
Published: May 2024

AbstractGlobal environmental change has redistributed earth’s biomass and the inputs and dynamics of basal detrital resources in ecosystems, contributing to the decline of biodiversity. Yet efforts to manage detrital necromass for biodiversity conservation are often overlooked or consider only singular resource types for focal species groups. We argue there is a significant opportunity to broaden our perspective of the spatiotemporal complexity among multiple necromass types for innovative biodiversity conservation. Here, we introduce an ecosystem-scale perspective to disentangling the spatial and temporal characteristics of multiple and distinct forms of necromass and their associated biota. We show that terrestrial and aquatic ecosystems contain a diversity of necromass types, each with contrasting temporal frequencies and magnitudes, and spatial density and configurations. By conceptualising an ecosystem in this way, we demonstrate that specific necromass dynamics can be identified and targeted for management that benefits the unique spatiotemporal requirements of dependent decomposer organisms and their critical role in ecosystem biomass conversion and nutrient recycling. We encourage conservation practitioners to think about necromass quantity, timing of inputs, spatial dynamics, and to engage with researchers to deepen our knowledge of how necromass might be manipulated to exploit the distinct attributes of different necromass types to help meet biodiversity conservation goals.
Portfolio Optimization with Prediction-Based Return Using Long Short-Term Memory Neural Networks: Testing on Upward and Downward European Markets
Authors: Martínez-Barbero Xavier , Cervelló-Royo Roberto , Ribal Javier 
Published: May 2024

AbstractIn recent years, artificial intelligence has helped to improve processes and performance in many different areas: in the field of portfolio optimization, the inputs play a crucial role, and the use of machine learning algorithms can improve the estimation of the inputs to create robust portfolios able to generate returns consistently. This paper combines classical mean–variance optimization and machine learning techniques, concretely long short-term memory neural networks to provide more accurate predicted returns and generate profitable portfolios for 10 holding periods that present different financial contexts. The proposed algorithm is trained and tested with historical EURO STOXX 50® Index data from January 2015 to December 2020, and from January 2021 to June 2022, respectively. Empirical results show that our LSTM neural networks are able to achieve minor predictive errors since the average of the MSE of the 10 holding periods is 0.00047, the average of the MAE is 0.01634, and predict the direction of returns with an average accuracy over the 10 investment periods of 95.8%. Our prediction-based portfolios consistently beat the EURO STOXX 50® Index, achieving superior positive results even during bear markets.
Accurate and energy efficient ad-hoc neural network for wafer map classification
Authors: Pinzari Ana , Baumela Thomas , Andrade Liliana , Martin Maxime , Coppola Marcello , Pétrot Frédéric 
Published: May 2024

AbstractYield is key to profitability in semiconductor manufacturing and controlling the fabrication process is therefore a key duty for engineers in silicon foundries. Analyzing the distribution of the defective dies on a wafer is a necessary step to identify process shifts, and a major step in this analysis takes the form of a classification of these distributions on wafer bitmaps called wafer maps. Current approaches use large to huge state-of-the-art neural networks to perform this classification. We claim that given the task at hand, the use of much smaller, purpose defined neural networks is possible without much accuracy loss, while requiring two orders of magnitude less power than the current solutions. Our work uses actual foundry data from STMicroelectronics 28 nm fabrication facilities that it aims at classifying in 58 categories. We performed experiments using different low power boards for which we report accuracy, power consumption and power efficiency. As a result, we show that to classify 224$$\times $$
×
224 wafer maps at foundry-throughput with an accuracy above 97% using a bit more than 1 W, is feasible.
Chemical and Electrophysiological Characterisation of Headspace Volatiles from Yeasts Attractive to Drosophila suzukii
Authors: Castellan Irene , Duménil Claire , Rehermann Guillermo , Eisenstecken Daniela , Bianchi Flavia , Robatscher Peter , Spitaler Urban , Favaro Riccardo , Schmidt Silvia , Becher Paul G. , Angeli Sergio 
Published: May 2024

AbstractChemical control of Drosophila suzukii (Diptera: Drosophilidae) based on the use of insecticides is particularly challenging as the insect attacks ripening fruits shortly before harvest. An alternative strategy may rely on the use of yeasts as phagostimulants and baits, applied on canopy as attract-and-kill formulations. The aim of this research was to identify the most attractive among six yeast species for D. suzukii: Saccharomyces cerevisiae, Hanseniaspora uvarum, Clavispora santaluciae, Saccharomycopsis vini, Issatchenkia terricola, and Metschnikowia pulcherrima. The volatile profile of C. santaluciae was described for the first time. Behavioural experiments identified H. uvarum and S. vini as the most attractive yeasts. The characterization of yeast headspace volatiles using direct headspace (DHS) and solid-phase microextraction (SPME) revealed several strain-specific compounds. With DHS injection, 19 volatiles were characterised, while SPME revealed 71 compounds constituting the yeast headspace. Both analyses revealed terpenoids including β-ocimene, citronellol, (Z)-geraniol (nerol), and geranial as distinct constituents of S. vini. H. uvarum and S. vini were further investigated using closed-loop stripping analysis (CSLA) and electroantennography. Out of 14 compounds quantified by CSLA, ethyl acetate, isoamyl acetate, β-myrcene, benzaldehyde and linalool were detected by D. suzukii antennae and might generate the strong attractiveness of S. vini and H. uvarum. Our results highlight a strong attraction of D. suzukii to various yeasts associated with both the flies and their habitat and demonstrate how different sampling methods can impact the results of volatile compound characterization. It remains to be demonstrated whether the distinct attraction is based on special adaptations to certain yeasts and to what extent the metabolites causing attraction are interchangeable.