bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of radial‐to‐aorta vascular anatomical variants on risk of failure in trans‐radial coronary procedures
Authors: Burzotta Francesco , Brancati Marta Francesca , Trani Carlo , Tommasino Antonella , Porto Italo , Niccoli Giampaolo , Leone Antonio Maria , Coluccia Valentina , Di Noi Paola , Crea Filippo 
Published: March 2012

AbstractObjectivesTo assess the impact of an “operative” classification of vascular anatomic variants on the feasibility of trans‐radial approach.BackgroundVascular anatomic variants located from the wrist to the aorta may influence the feasibility of trans‐radial procedures. Recently, a new “operative” classification of these variants was proposed.MethodsConsecutive trans‐radial diagnostic or interventional catheterizations were considered. Vascular anatomic variants were classified according to 10 categories and sub‐grouped according to the ABC classification (A: radial‐brachial arterial axis; B: axillary‐subclavian‐anonymous axis; C: aortic arch). Primary study end‐point was failure of trans‐radial approach (necessity to cross‐over to another approach to complete the procedure).ResultsThree thousand four hundred seventy‐seven consecutive radial procedures were considered. Anatomic variants were diagnosed in 308 procedures (8.8%): A variants: 7.2%, B variants: 1.9%; C variants: 0.3%. Failure occurred in 2.0% of procedures. Failure rate was 0.7% in the absence of variants vs.15.2% in the presence of any variant (P < 0.0001, OR 27.7, 95%CI 16.3–46.9). Each of the 10 variants was significantly associated with increased failure rate. Each of the three level‐subgroups of variants was significantly associated to the risk of failure (failure 14.7% in A level, 13.9% in B level, 33.3% in C level; P < 0.0001 vs. absence of variants).ConclusionsFailure of trans‐radial procedures is associated to anatomic variants located from the wrist to the aorta. The “operative” ABC classification of anatomic variants is useful not only to categorize these anatomic variants, but also to predict the risk of failure of trans‐radial approach. © 2012 Wiley Periodicals, Inc.
Treatment of an iatrogenic femoral artery pseudoaneurysm with concomitant arteriovenous fistula with percutaneous implantation of an amplatzer vascular plug
Authors: Shetty Ranjith , Lotun Kapildeo 
Published: March 2012

AbstractIatrogenic pseudoaneurysms can occur following percutaneous cardiac and peripheral procedures. There are multiple modalities available for the treatment of pseudoaneurysms including ultrasound guided compression repair, ultrasound guided thrombin injection, or endovascular repair with covered stent placement. If these methods are not indicated or unsuccessful, patients typically require open surgical repair. We report a case of a woman with a post‐procedural pseudoaneurysm with concomitant arteriovenous fistula who was treated percutaneously with the implantation of an Amplatzer vascular plug. This novel technique was safe and effective and allowed our patient to avoid the morbidity and mortality associated with surgical repair. © 2012 Wiley Periodicals, Inc.
Heme Oxygenase Inhibition by α‐(1H‐Imidazol‐1‐yl)‐ω‐phenylalkanes: Effect of Introduction of Heteroatoms in the Alkyl Linker
Authors: Vlahakis Jason Z. , Lazar Carmen , Roman Gheorghe , Vukomanovic Dragic , Nakatsu Kanji , Szarek Walter A. 
Published: March 2012

AbstractSeveral α‐(1H‐imidazol‐1‐yl)‐ω‐phenylalkanes were synthesized and evaluated as novel inhibitors of heme oxygenase (HO). These compounds were found to be potent and selective for the stress‐induced isozyme HO‐1, showing mostly weak activity toward the constitutive isozyme HO‐2. The introduction of an oxygen atom in the alkyl linker produced analogues with decreased potency toward HO‐1, whereas the presence of a sulfur atom in the linker gave rise to analogues with greater potency toward HO‐1 than the carbon‐containing analogues. The most potent compounds studied contained a five‐atom linker between the imidazolyl and phenyl moieties, whereas the most HO‐1‐selective compounds contained a four‐atom linker between these groups. The compounds with a five‐atom linker containing a heteroatom (O or S) were found to be the most potent inhibitors of HO‐2; 1‐(N‐benzylamino)‐3‐(1H‐imidazol‐1‐yl)propane dihydrochloride, with a nitrogen atom in the linker, was found to be inactive.
Comparative Binding Energy (COMBINE) Analysis Supports a Proposal for the Binding Mode of Epothilones to β‐Tubulin
Authors: Coderch Claire , Klett Javier , Morreale Antonio , Díaz J. Fernando , Gago Federico 
Published: March 2012

AbstractThe conformational preferences of epothilone A (EPA) and a 12,13‐cyclopropyl C12‐epimerized analogue were explored in aqueous solution using molecular dynamics simulations. The simulated conformers that provided an optimal fit in the paclitaxel binding site of mammalian β‐tubulin were then selected. The resulting modeled complexes were simulated before and after refinement of the M‐loop to improve the fitting and assess ligand stability within the binding pocket. The tubulin‐bound conformation of EPA was found to be unlike a previously reported solution obtained through mixed crystallographic/NMR/modeling studies. However, our conformation was in agreement with an NMR‐based proposal although the exact binding pose within the site was different. Molecular models were built for the complexes of 14 epothilone derivatives with β‐tubulin. A projection to latent structures regression method succeeded in providing a good prediction of the experimentally measured binding enthalpies for the whole set of ligands by assigning weights to a selection of interaction energy terms. These receptor‐based, quantitative structure–activity relationships support the proposed binding mode, help confirm and interpret previously acquired experimental data, shed additional light on the effect of several β‐tubulin mutations on ligand binding, and can potentially direct further experimental studies.
Nonspecific predictors of weight gain in the early stages of outpatient cognitive behavioral therapy for adults with anorexia nervosa: Replication and extension
Authors: Marcoulides Olivia Kyriacou , Waller Glenn 
Published: March 2012

AbstractObjective:This study extends previous work, examining psychological factors that influence the level of weight gain across the first 20 sessions of cognitive behavioral therapy (CBT) for anorexia nervosa.Method:Thirty‐two patients with anorexia nervosa (mean body mass index (BMI) = 16.0; SD = 1.11) completed measures of eating attitudes and comorbid axis 1 pathology at the outset of CBT, and their weight gain was measured at the 6th and 20th sessions of the therapy.Results:Unhealthy eating attitudes at the start of therapy were associated with slower weight gain across the first 20 sessions of CBT. In contrast, higher levels of pretreatment axis 1 pathology were associated with slower weight gain only after the 6th session. The axis 1 features that moderated weight gain over 20 sessions of CBT were broader than those that had previously been shown to predict weight gain over the first 10 CBT sessions.Discussion:During CBT for anorexia nervosa, weight gain might be enhanced by addressing a range of aspects of axis 1 pathology (e.g., depression, hostility, and features of anxiety). However, the approach is likely to be less important at first than directly addressing eating pathology and overvalued ideas about eating, shape, and weight. © 2012 by Wiley Periodicals, Inc. (Int J Eat Disord 2012; 45:746–750)
DFT Studies on the Mechanism of Alcohol Oxidation Catalyzed by the NiIII/bipy Complex
Authors: Cheng Lin , Li Jie , Li Jianing , Zheng Hongna , Wu Zhijian 
Published: March 2012

AbstractOn the basis of our previous DFT calculations on the catalytic reaction cycle catalyzed by CuII/bipy (2,2′‐bipyridine), a new NiIII/bipy catalyst has been designed. By examining the mechanism of alcohol oxidation catalyzed by the NiIII/bipy catalyst, it was found that the barrier calculated for the rate‐determining step (16.3 kcal/mol) is 12.2 kcal/mol lower than that for the corresponding CuII/bipy catalyst. This indicates that the NiIII/bipy catalyst might be a potential catalyst for green alcohol oxidation. In addition, the reasons for the higher activity of the NiIII/bipy catalyst relative to the CuII/bipy catalyst are discussed. It was found that the unoccupied NiIII (d7) d orbital might be the reason for the higher activity of the NiIII/bipy catalyst. The singly occupied NiIII (d7) d orbital plays a very important role in producing the final product (CH3CHO) in the absence of an oxidation auxilliary.
Diversified Aminohydantoins from Ureas and Thioureas Tethered to Amides
Authors: Bepary Sukumar , Youn In Kwon , Lim Hee‐Jong , Lee Ge Hyeong 
Published: March 2012

AbstractIntramolecular cyclization of thioureas or ureas tethered to amides afforded 2‐iminohydantoins and 2‐amino‐1H‐imidazol‐4(5H)‐ones in very high yields (87–100 %) regardless of the substituent (alkyls or aryls). This reaction proceeds through carbodiimides and iminium ions as intermediates. Among the reagents used to generate the carbodiimides, CBr4/Ph3P, CCl4/Ph3P, O,O′‐bis(2′‐pyridyl)thiocarbonate, and HgO were investigated.
Initial experience using a bipolar radiofrequency ablation device for hemostasis during thyroidectomy
Authors: Baldwin Keith , Haniff Michelle , Somasundar Ponnandai 
Published: March 2012

AbstractBackgroundThe purpose of this study was to evaluate a novel bipolar radiofrequency ablation (BRFA) device using nanotechnology for division of all named vessels during thyroidectomy.MethodsAll thyroidectomies from January 2008 to July 2010 at a single institution used the BRFA device (EnSeal, Ethicon Endo‐Surgery, Cincinnati, OH) for hemostasis. Clinicopathologic data and complications were recorded and compared with existing literature using other energy devices.ResultsFifty‐eight thyroidectomies were performed. Mean age was 54.7 years, and mean operating room time was 81 minutes. The average estimated blood loss was 46 mL. Ninety percent of patients were discharged in <23 hours. There were no hemorrhages. There was 1 recurrent laryngeal nerve (RLN) injury, and 1 case of transient hypocalcemia.ConclusionThis first small series using the BRFA device reveals initial safety and effectiveness for thyroid hemostasis, and warrants further study. The minimal thermal spread inherent in this device may make it an attractive option when structures such as the RLN may be near the zone of hemostasis. © 2012 Wiley Periodicals, Inc. Head Neck, 2013
Overexpression of the nuclear factor‐kappa B (p65) in association with local failure in patients with head and neck carcinoma undergong radiotherapy or chemoradiotherapy
Authors: Quintana Ana , Avilés Francesc X , Terra Ximena , Alcolea Sonia , Camacho Mercedes , Quer Miquel , Vila Luis , León Xavier 
Published: March 2012

AbstractBackgroundThe aim of this study was to evaluate nuclear factor‐kappa B (NF‐κB) expression as a biologic marker to predict local control in patients with head and neck squamous cell carcinoma (HNSCC) treated with radiotherapy or chemoradiotherapy.MethodsThe mRNA expression levels of the NF‐κB family genes were determined with real‐time–polymerase chain reaction in 77 patients with HNSCC treated with radiotherapy or chemoradiotherapy.ResultsThe mRNA NF‐κB (p65) expression in pretreatment tumors was significantly related to local control (p = .03). The 5‐year local recurrence‐free survival rate in patients with low‐level NF‐κB (p65) expression (n = 42) was 79.9%, and in patients with a high level of expression it was 42.1% (p = .001). In a multivariate analysis, the mRNA NF‐κB (p65) expression level was the only variable related to local control of the tumor.ConclusionExpression of the NF‐κB (p65) gene may be a radiosensitivity marker for patients with a HNSCC. © 2012 Wiley Periodicals, Inc. Head Neck, 2013
Efficient Synthesis of Novel Coumarin‐3‐carboxamides (=2‐Oxo‐2H‐1‐benzopyran‐3‐carboxamides) Containing Lipophilic Spacers
Authors: Balalaie Saeed , Bigdeli Mohammad Ali , Sheikhhosseini Enayatollah , Habibi Azizollah , Moghadam Hamed Piri , Naderi Mehrnoush 
Published: March 2012

AbstractThe novel coumarin‐3‐carboxamides (=2‐oxo‐2H‐1‐benzopyran‐3‐carboxamides) 5a–5g containing lipophilic spacers were synthesized through the Ugi‐four‐component reaction (Scheme 1). The reactions of aromatic aldehydes 1, 4,4′‐oxybis[benzenamine] or 4,4′‐methylenebis[benzenamine] as diamine 2, coumarin‐3‐carboxylic acid (=2‐oxo‐2H‐benzopyran‐3‐carboxylic acid; 3), and alkyl isocyanides 4 lead to the desired substituted coumarin‐3‐carboxamides 5a–5g at room temperature with high bond‐forming efficiency. These novel coumarin derivatives exhibit brilliant fluorescence at 544 nm in CHCl3.
‘Click Synthesis’ of Some Novel O‐Substituted Oximes Containing 1,2,3‐Triazole‐1,4‐diyl Residues as New Analogs of β‐Adrenoceptor Antagonists
Authors: Rad Mohammad Navid Soltani , Behrouz Somayeh , Karimitabar Fatemeh , Khalafi‐Nezhad Ali 
Published: March 2012

AbstractThe ‘click synthesis’ of some novel O‐substituted oximes, 7a–7t, which contain 1,2,3‐triazolediyl residues, as new analogs of β‐adrenoceptor antagonists is described (Schemes 1–4). The synthesis of these compounds was achieved in four to five steps. The formation of oximes of 9H‐fluoren‐9‐one and benzophenone, i.e., 9a and 9b, respectively, followed by their reaction with propargyl bromide, afforded O‐propargyl oximes 10a and 10b, respectively, which by a subsequent CuI‐catalyzed Huisgen cycloaddition with prepared β‐azido alcohols 11a–11j (Schemes 2 and 3), led to the target compounds 7a–7t in good yields.
Preparation of Pseudo‐Peptide Building Blocks with retro‐Thioamide Bond Mediated via Thiocarbamoyl Meldrum's Acid
Authors: Janikowska Karolina , Makowiec Sławomir , Rachoń Janusz 
Published: March 2012

AbstractAn easy and efficient synthesis of pseudo‐tripeptide containing a thiomalonamide moiety was developed. Isothiocyanate derivatives of amino acids react smoothly with 2,2‐dimethyl‐1,3‐dioxane‐4,6‐dione (Meldrum's acid) to yield new thiocarbamoyl derivatives of Meldrum's acids. Thermal decomposition of these new derivatives leads to thiocarbamoyl ketenes, which acylate amino acid esters to give pseudo‐tripeptides.
Exaltone® (=Cyclopentadecanone) from Isomuscone® (=Cyclohexadecanone), a One‐C‐Atom Ring‐Contraction Methodology via a Stereospecific Favorskii Rearrangement: Regioselective Application to (−)‐(R)‐Muscone
Authors: Chapuis Christian , Robvieux Fabrice , Cantatore Carole , Saint‐Léger Christine , Maggi Laurent 
Published: March 2012

AbstractTreatment of cyclohexadecanone (1g; with I2 (2.2 mol‐euqiv.) and KOH in MeOH) furnished the unsaturated (Z)‐ester 2g in 83% yield, via a stereospecific Favorskii rearrangement (Scheme 1). Further treatment with 3‐chloroperbenzoic acid (m‐CPBA) afforded the unreported epoxy ester 3g (88% yield), which was cleaved in 33% yield to Exaltone® (=cyclopentadecanone; 1f) with NaOH in MeOH/H2O and then HCl at 65°. This methodology was similarly extended to higher (C17) and lower (C15 to C11) cyclic ketone analogues, as well as regioselectively to (−)‐(R)‐muscone (5c) and homomuscone (5f) (Scheme 2). Olfactive properties of the corresponding macrocyclic 1‐oxaspiro[2,n]alkanes and ‐alkenes 4 and 8, resulting from a CoreyChaykovsky oxiranylation, are also presented.
Characterization of drug resistance mutations in naïve and ART‐treated patients infected with HIV‐1 in Yaounde, Cameroon
Authors: Ceccarelli Laura , Salpini Romina , Moudourou Sylvie , Cento Valeria , Santoro Maria M. , Fokam Joseph , Takou Desire , Nanfack Aubin , Dori Luca , Torimiro Judith , Sarmati Loredana , Andreoni Massimo , Perno Carlo F. , Colizzi Vittorio , Cappelli Giulia 
Published: March 2012

AbstractCurrently the prevalence of HIV‐1 infection in Cameroon is 5.1%, CRF02_AG subtype is responsible for about 50% of infections. Since an HIV‐1 drug resistance test is not yet available widely, accurate data on the prevalence of resistant viral strains are missing. The objective of this study was to determine HIV‐1 genetic diversity and to characterize HIV‐1 mutations conferring drug resistance among antiretroviral therapy (ART)‐naïve and ART‐treated patients. A cohort of 239 patients infected with HIV were followed‐up between January 2007 and July 2010 in Cameroon. Two hundred and sixteen plasma samples were sequenced for phylogenetic analysis and identification of drug resistance mutations in the HIV‐1 pol region. A significant genetic diversity was found: Seven pure subtypes (A1, A3, D, F1, F2, G, H), nine circulating recombinant forms (CRFs: 01_AE, 02_AG, 06cpx, 09cpx, 11cpx, 13cpx, 16cpx, 18cpx, 37cpx) and one new unique recombinant form (URF) (G/F2). The rate of transmitted drug resistance (TDR) in naïve patients was 8.2% (4/49). Around 80% of patients failing a first‐line ART harbored a virus with at least one resistance mutation to two antiretroviral (ARV) classes, and 36% of those failing a second‐line regimen carried a virus with at least one resistant mutation to three ARV classes. The high level of drug resistance observed in the cohort is alarming because this occurred as a result of only few years of treatment. Adherence to therapy, adequate education of physicians, and the appropriate use of genotypic resistance assay are critical points of intervention for the improvement of patient care. J. Med. Virol. 84:721–727, 2012. © 2012 Wiley Periodicals, Inc.
Genetic characterization of measles viruses that circulated in Thailand from 1998 to 2008
Authors: Pattamadilok Sirima , Incomserb Patcha , Primsirikunawut Athiwat , Lukebua Atchariya , Rota Paul A. , Sawanpanyalert Pathom 
Published: March 2012

AbstractDuring the period between 1998 and 2008, 48 representative measles viruses (MeVs) circulating in Thailand were subjected to genetic characterization. Three genotypes, G2, D5, and D9 were detected. The results suggested that measles genotype D5, which has been circulating since at least 1998, is the endemic genotype in Thailand. Genotype G2 was detected between 1998 and 2001. In addition, almost all of the MeVs detected throughout the country in 2008 were genotype D9. This is the first report of genotype D9 in Thailand. This report provides important baseline data about measles genotypes in Thailand and this information will be needed to help verify measles elimination in Thailand. J. Med. Virol. 84:804–813, 2012. © 2012 Wiley Periodicals, Inc.
Increased frequency of Th17 cells in the peripheral blood of children infected with enterovirus 71
Authors: Chen Jianguo , Tong Jia , Liu Haibing , Liu Yingzhao , Su Zhaoliang , Wang Shengjun , Shi Yan , Zheng Dong , Sandoghchian Siamak , Geng Jianzhong , Xu Huaxi 
Published: March 2012

AbstractEnterovirus 71 (EV71) affects the health of young children globally causing severe neurologic diseases. The relationship between EV71 infection and T helper type 17 (Th17) has not been described, although this new Th subset or interleukin‐17 (IL‐17) has been reported to be associated with other viral infections. The purpose of the current study was to describe the immune profile involving Th17 cells, neutrophils, and related factors and to speculate on the possible immunopathogenesis of EV71 infections. Flow cytometry and an automatic blood cell counter were used to analyze circulating Th17 cells and count neutrophils, respectively. Expression of acid‐related orphan nuclear receptor gamma t (ROR γt) was evaluated by reverse‐transcriptional PCR, and enzyme linked immunosorbent assays (ELISAs) were used for detecting concentrations of IL‐17, IL‐23, and IFN‐γ. The results showed that the frequencies of Th17 cells (1.47 ± 0.87%) and the number of neutrophils (7.4 ± 4.1 × 109/L) in peripheral blood samples from children infected with EV71 were significantly higher compared to controls. In addition, there was a statistically higher expression of ROR γt in peripheral blood mononuclear cells (PBMCs) and elevated concentrations of IL‐17 and IL‐23 in sera, but lower IFN‐γ production during EV71 infections. The findings suggest that Th17 cells are mediators during the immunologic process. J. Med. Virol. 84:763–767, 2012. © 2012 Wiley Periodicals, Inc.
Protection by cilostazol against amyloid‐β1–40‐induced suppression of viability and neurite elongation through activation of CK2α in HT22 mouse hippocampal cells
Authors: Lee Hye Rin , Park So Youn , Kim Hye Young , Shin Hwa Kyoung , Lee Won Suk , Rhim Byung Yong , Hong Ki Whan , Kim Chi Dae 
Published: March 2012

AbstractAmyloid‐β peptide (Aβ) deposits in the brain are critical in the neurotoxicity induced by Aβ. This study elucidates the underlying signaling pathway by which cilostazol protects HT22 neuronal cells from Aβ1–40 (3–30 μM)‐induced deterioration of cell proliferation, viability, and neurite elongation. Cilostazol rescued HT22 cells from the apoptotic cell death induced by Aβ toxicity through the downregulation of phosphorylated p53 (Ser15), Bax, and caspase‐3 and the upregulation of Bcl‐2 expression, which improved neuronal cell proliferation and viability. Furthermore, Aβ1–40 suppressed both phosphorylated CK2α protein expression and CK2 activity in the cytosol; these were concentration dependently recovered by cilostazol (3–30 μM). Cilostazol significantly increased the levels of GSK‐3β phosphorylation at Ser9 and β‐catenin phosphorylation at Ser675 in the cytosol and nucleus. Cilostazol effects were reversed by KT5720 (1 μM, PKA inhibitor) and TBCA (40 μM, inhibitor of CK2) and CK2α knockdown by siRNA transfection. Likewise, Aβ‐stimulated GSK‐3β phosphorylation at Tyr 216 was decreased by cilostazol in the control but not in the CK2α siRNA‐transfected cells. Furthermore, the Aβ (10 μM)‐induced suppression of neurite elongation was recovered by cilostazol; this recovery was attenuated by inhibitors such as KT5720 and TBCA and blocked by CK2α knockdown. In conclusion, increased cAMP‐dependent protein kinase‐linked CK2α activation underlies the pharmacological effects of cilostazol in downregulating p53 phosphorylation at Ser15 and upregulating GSK‐3β phosphorylation at Ser9/β‐catenin phosphorylation at Ser675, thereby suppressing Aβ1–40‐induced neurotoxicity and improving neurite elongation. © 2012 Wiley Periodicals, Inc.
Neural correlates of cognitive ability
Authors: Brancucci Alfredo 
Published: March 2012

AbstractThe challenge to neuroscientists working on intelligence is to discover what neural structures and mechanisms are at the basis of such a complex and variegated capability. Several psychologists agree on the view that behavioral flexibility is a good measure of intelligence, resulting in the appearance of novel solutions that are not part of the animal's normal behavior. This article tries to indicate how the supposed differences in intelligence between species can be related to brain properties and suggests that the best neural indicators may be the ones that convey more information processing capacity to the brain, i.e., high conduction velocity of fibers and small distances between neurons, associated with a high number of neurons and an adequate level of connectivity. The neural bases of human intelligence have been investigated by means of anatomical, neurophysiological, and neuropsychological methods. These investigations have led to two important findings that are briefly discussed: the parietofrontal integration theory of intelligence, which assumes that a distributed network of cortical areas having its main nodes in the frontal and parietal lobes constitutes a probable substrate for smart behavior, and the neural efficiency hypothesis, according to which intelligent people process information more efficiently, showing weaker neural activations in a smaller number of areas than less intelligent people. © 2012 Wiley Periodicals, Inc.