bluuebunny/crossref_metadata_2025_split huggingface dataset:
At-sea distribution of marine predators around South Georgia during austral winter, with implications for fisheries management
Authors: Owen Kate A. , Goggins Meghan , Black Andy , Ashburner Jonathan , Wilson Alastair , Hollyman Philip R. , Trathan Philip N. , Waluda Claire M. , Collins Martin A. 
Published: May 2024

AbstractThe sub-Antarctic island of South Georgia is surrounded by highly productive waters, supporting dense aggregations of Antarctic krill (Euphausia superba), a vital food source for globally important seabird and marine mammal populations. These waters also support a commercial fishery for Antarctic krill. Regular monitoring of key krill predator species is undertaken at South Georgia to detect any changes in the ecosystem in response to harvesting activities. This monitoring provides essential data but is focused on land-breeding animals during the austral summer, whilst the krill fishery operates exclusively in winter. Here, we report the results of at-sea surveys to investigate abundance and distribution of krill-dependent predators from winter 2010 and 2011, which represented a “poor” krill year and “good” krill year, respectively. Correspondingly in 2011 higher numbers of krill predators were observed; notably Antarctic fur seals (Arctocephalus gazella) across the northern shelf. Spatial overlap between fur seals and the krill fishery occurred mainly within the krill fishery hotspot to the north-east, highlighting the potential for locally high levels of competition. Cetaceans were observed during both survey years, but in low numbers compared to recent studies. Gentoo penguins (Pygoscelis papua) were the most frequently observed penguin species, showing an inshore distribution and almost no overlap with the krill fishery. Diving-petrels (Pelecanoides spp.) were the most abundant flying seabirds, observed across all transects, with particularly high densities to the south in early winter 2010. In conclusion, this survey provides valuable baseline data on the distribution of South Georgia’s predators during the winter months.
A comprehensive guide to intracavity absorption spectroscopy
Authors: Fjodorow Peter 
Published: May 2024

AbstractThe enormous sensitivity of intracavity absorption spectroscopy (ICAS), as well as its unique ability to tolerate high broadband losses caused by, e.g., optical windows and light scattering, is being exploited by only a few research groups worldwide. The reason seems to be the lack of comprehensive literature, such that the field remains difficult to access for non-experts, in particular for engineers and chemists, who might derive the most benefits from applying ICAS. In particular, the missing connection to this target audience appears to be two-fold: (i) the seeming complexity of the theory, and (ii) the necessity to setup homemade laser systems. However, once some basic understanding and knowledge is obtained, both aspects appear to be of similar complexity as with other spectroscopic techniques. Therefore, the current work is aiming at (i) providing a comprehensive review of the theoretical basics of ICAS, and (ii) describing the most important practical aspects that need to be considered for a successful realization of ICAS measurements. To ensure maximum clarity, illustrative practical examples of recent work are used throughout the paper.
Spontaneous regression of an interhemispheric arachnoid cyst: illustrative case
Authors: Fuentes Angelica M. , Jane John A. 
Published: May 2024

Abstract
Background
Intracranial arachnoid cysts are benign collections of cerebrospinal fluid that are often asymptomatic and discovered incidentally. An interhemispheric location of these lesions is rare, with only a few such cases reported in the literature. Though spontaneous regression of arachnoid cysts has been described in other locations, to date this phenomenon has not been reported in interhemispheric fissure cysts.

Observations
In this report, we describe a patient with a large, multiloculated interhemispheric arachnoid cyst diagnosed on prenatal ultrasound. She did not exhibit neurologic deficits or signs of increased intracranial pressure and was observed with serial imaging. After several years of observation, imaging revealed spontaneous and progressive decrease in the cyst size.

Lessons
We illustrate a case of regression of an interhemispheric arachnoid cyst in a pediatric patient. To our knowledge, this is the first reported case of spontaneous shrinkage of an arachnoid cyst in this location. Although the current presentation is rare, this reporting adds to the current understanding of natural history of arachnoid cysts and provides an example of radiographical improvement without intervention of a cyst located within the interhemispheric fissure.
Changing epidemiology of inflammatory bowel disease in children and adolescents
Authors: Long Dan , Wang Chenchen , Huang Yingtao , Mao Chenhan , Xu Yin , Zhu Ying 
Published: May 2024

Abstract
Background
The incidence of inflammatory bowel disease (IBD) is rising worldwide, but epidemiological data on children and adolescents are lacking. Understanding the global burden of IBD among children and adolescents is essential for global standardization of methodology and treatment options.

Methods
This is a cross-sectional study based on aggregated data. We estimated the prevalence and incidence of IBD in children and adolescents between 1990 and 2019 according to the Global Burden of Disease Study 2019 (GBD 2019). Age-standardized rates (ASRs) and estimated annual percentage changes (EAPCs) were used to compare the burden and trends between different regions and countries.

Results
In 2019, there were 25,659 new cases and 88,829 prevalent cases of IBD among children and adolescents globally, representing an increase of 22.8% and 18.5%, respectively, compared to 1990. Over the past 30 years, the incidence and prevalence of IBD among children and adolescents have been highest in high SDI regions, with the most significant increases in East Asia and high-income Asia Pacific. At the age level, incidence and prevalence were significantly higher in the 15–19-year-old age group, while the < 5-year-old group showed the most significant increase in incidence and prevalence.

Conclusion
The incidence of IBD in children and adolescents is significantly on the rise in some countries and regions, and IBD will remain an important public health issue with extensive healthcare and economic costs in the future. The reported IBD burden in children and adolescents at the global, regional, and national levels will assist in the development of more precise health policies.
The effect of niacin on inflammatory markers and adipokines: a systematic review and meta-analysis of interventional studies
Authors: Rad Esmaeil Yousefi , Saboori Somayeh , Tammam Jonathan , Thondre Pariyarath Sangeetha , Coe Shelly 
Published: May 2024

Abstract
Purpose
Niacin (nicotinic acid), known for its lipid-modifying effects, has been explored for its potential anti-inflammatory properties and potential to affect adipokines secretion from adipose tissue. The aim of this systematic review and meta-analysis was to assess the effects of niacin on inflammatory markers and adipokines.

Methods
A comprehensive search was conducted across five databases: PubMed, Scopus, Cochrane Library, Embase, and ISI Web of Science. Randomized controlled trials exploring the effects of niacin on inflammatory markers (CRP, IL-6, TNF-α) and adipokines (Adiponectin, Leptin) were included. Pooled effect sizes were analysed using a random-effects model, and additional procedures including subgroup analyses, sensitivity analysis and dose-response analysis were also performed.

Results
From an initial 1279 articles, fifteen randomized controlled trials (RCTs) were included. Niacin administration demonstrated a notable reduction in CRP levels (SMD: -0.88, 95% CI: -1.46 to -0.30, p = 0.003). Subgroup analyses confirmed CRP reductions in trials with intervention durations ≤ 24 weeks, doses ≤ 1000 mg/day, and elevated baseline CRP levels (> 3 mg/l). The meta-analysis of IL-6 and TNF-α revealed significant TNF-α reductions, while IL-6 reduction did not reach statistical significance. Niacin administration also substantially elevated Adiponectin (SMD: 3.52, 95% CI: 0.95 to 6.1, p = 0.007) and Leptin (SMD: 1.90, 95% CI: 0.03 to 3.77, p = 0.04) levels.

Conclusion
Niacin treatment is associated with significant reductions in CRP and TNF-α levels, suggesting potential anti-inflammatory effects. Additionally, niacin positively influences adipokines, increasing Adiponectin and Leptin levels. These findings provide insights for future research and clinical applications targeting inflammation and metabolic dysregulation.
Is there a relationship between the severity of obstructive sleep apnea syndrome and the systemic immune inflammation index?
Authors: Gölen Meltem Karacan , Işık Şaziye Melike , Arıkan Veysel 
Published: May 2024

Abstract
Aim
Vascular dysfunction, oxidative stress and systemic inflammation are considered responsible for the pathophysiology of Obstructive sleep apnea syndrome (OSAS). It is thought that desaturation due to apnea–hypopnea attacks in OSAS patients activates inflammatory pathways. In this study, we aimed to reveal the relationship between inflammation parameters Systemic immune inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratios (PLR) severity of OSAS in patients who underwent polysomnography in our hospital’s sleep laboratory.

Methods
We grouped our 171 patients who were followed up in our sleep laboratory with the diagnosis of OSAS according to their AHI values. We evaluated the correlation of SII, NLR, and PLR values obtained from the complete blood tests of our patients with OSAS diagnosis and OSAS severity.

Results
The mean NLR, PLR and SII values of patients with OSAS were statistically significantly higher than those without OSAS (p < 0.05). A positive correlation of 18% was found between the presence of OSAS and the SII value (p = 0.016). No statistically significant difference was found when comparing OSAS severity and NLR, PLR and SII values (p > 0.05).

Conclusion
We observed that SII, NLR and PLR parameters, which are rapidly assessable systemic inflammation markers of this process, were independently associated in patients diagnosed with OSAS and that there was no change in SII, NLR, and PLR parameters with OSAS severity.
Graph-enhanced deep material network: multiscale materials modeling with microstructural informatics
Authors: Jean Jimmy Gaspard , Su Tung-Huan , Huang Szu-Jui , Wu Cheng-Tang , Chen Chuin-Shan 
Published: May 2024

AbstractThis study addresses the fundamental challenge of extending the deep material network (DMN) to accommodate multiple microstructures. DMN has gained significant attention due to its ability to be used for fast and accurate nonlinear multiscale modeling while being only trained on linear elastic data. Due to its limitation to a single microstructure, various works sought to generalize it based on the macroscopic description of microstructures. In this work, we utilize a mechanistic machine learning approach grounded instead in microstructural informatics, which can potentially be used for any family of microstructures. This is achieved by learning from the graph representation of microstructures through graph neural networks. Such an approach is a first in works related to DMN. We propose a mixed graph neural network (GNN)-DMN model that can single-handedly treat multiple microstructures and derive their DMN representations. Two examples are designed to demonstrate the validity and reliability of the approach, even when it comes to the prediction of nonlinear responses for microstructures unseen during training. Furthermore, the model trained on microstructures with complex topology accurately makes inferences on microstructures created under different and simpler assumptions. Our work opens the door for the possibility of unifying the multiscale modeling of many families of microstructures under a single model, as well as new possibilities in material design.
The 2023 Merger Guidelines: Law, Fact, and Method
Authors: Hovenkamp Herbert 
Published: May 2024

AbstractThe final version of the 2023 Merger Guidelines, which were issued in December 2023, is a vast improvement over an earlier draft—which indicates that the Agencies took the many comments that they received on a draft very seriously. These Guidelines break some new ground that older Guidelines did not address, and make many positive contributions, which this paper spells out. They are also excessively nostalgic for a past era, however, and this may explain their propen sity to treat empirical questions as issues of law: This is one way to insulate these Guidelines from further revision. The excessive reliance on one decision, Brown Shoe, is unfortunate—particularly since that decision has been so often repudiated, even by the Supreme Court itself. This paper pays particular attention to: the Guidelines’ treatment of structural triggers and direct measures of competitive effects; their aggressive position on potential competition mergers; their willingness to weigh a “trend” toward concentration as a factor; and their treatment of serial acquisitions. The Guidelines include a welcome new section on mergers involving multi-sided networks, although their view of networks is too one-sided; and the Guidelines also contain an expanded section on mergers with harmful effects on suppliers—including labor. The Guidelines’ treatment of market definition is likely to lead to underenforcement because they define markets too broadly. Finally, the Guidelines could have made better use of recent retrospective studies—many of which would have provided further support for the substantive positions that the Guidelines take.
White Coat Hypertension & Cardiovascular Outcomes
Authors: Townsend Raymond R. , Cohen Jordana B. 
Published: May 2024

Abstract
Purpose of Review
This review aims to inform the reader of the complexity of blood pressure responses when comparing blood pressure measured in the medical environment to that outside the medical environment. In addition, we summarize what is known about current predictors of white coat hypertension, reevaluate the relationship of white coat hypertension to cardiovascular outcomes, and provide some clinical guidance on management.

Recent Findings
Differences in outcomes exist when white coat effect occurs in unmedicated people versus the white coat effects in those on antihypertensive therapy.

Summary
White coat hypertension is relatively common, carries a small but definite increase in cardiovascular risk, and is prone to conversion to sustained hypertension. Future research will hopefully tease out the roles of ancillary findings that characterize a white coat hypertensive (like modest elevations in creatinine, glucose and triglycerides) in the elevated cardiovascular risk, and test the effectiveness of mitigation strategies in these patients.
Exploring energy selection methods for robust biologically optimized carbon ion arc for head&neck cancer patients
Authors: Volz Lennart , Sheng Yinxiangzi , Kong Lin , Durante Marco , Graeff Christian 
Published: May 2024

Abstract
Background
Due to the advantageous depth dose profile of carbon ion beams, carbon ion therapy is commonly applied in the form of intensity modulated particle therapy (IMPT) with few treatment fields. Carbon ion arc therapy (C-Arc) has recently been proposed to improve dose conformity and increase the dose-averaged linear energy transfer (LETd) inside the target to levels relevant for overcoming tumor radioresistance. In this work, we investigate different energy selection approaches for C-Arc, including a novel greedy energy layer refinement strategy.

Methods
Robust biologically optimized C-Arc plans were generated for six head &neck cancer patient previously treated at the Shanghai Proton and Heavy Ion Center (SPHIC). Different heuristic approaches for mono- and dual-energy C-Arc were implemented, and compared to carbon IMPT pans. A novel greedy energy layer refinement was developed, acting directly on the dose influence matrix, rather than on an iterative plan optimization. A key challenge in C-Arc with few energy layers per angle is the sharpness of the carbon ion Bragg peak, which is challenging for plan robustness. To improve robustness and plan quality, we propose the use of a 6 mm ripple filter instead of the typical 3 mm ripple filter used for carbon IMPT.

Results
Most mono-energetic C-Arc plans were able to meet the established clinical goals, but some of the heuristic energy selection schemes were not universally applicable with low plan quality in some patients. The developed energy layer refinement strategy delivered high quality plans even for complex cases. Mono-energetic C-Arc plans presented an average increase between 10% and 33% in the maximum LETd in the target, with similar or up to 19% improved average target LETd$$_{50\%}$$

50
%

compared to the IMPT carbon ion plans. C-Arc plans with 2 energies per treatment angle, for the employed energy selection heuristic, improved dosimetric quality compared to mono-energetic C-Arc plans, but did not provide the same natural improvement in LETd compared to IMPT.

Conclusions
For small, centrally located targets C-Arc demonstrates the greatest potential, but feasible plans could also be achieved for more complex cases in this work. Further development is necessary for improving C-Arc delivery efficiency and plan quality toward possible clinical application.
Polyamines: the pivotal amines in influencing the tumor microenvironment
Authors: Holbert Cassandra E. , Casero Robert A. , Stewart Tracy Murray 
Published: May 2024

AbstractCellular proliferation, function and survival is reliant upon maintaining appropriate intracellular polyamine levels. Due to increased metabolic needs, cancer cells elevate their polyamine pools through coordinated metabolism and uptake. High levels of polyamines have been linked to more immunosuppressive tumor microenvironments (TME) as polyamines support the growth and function of many immunosuppressive cell types such as MDSCs, macrophages and regulatory T-cells. As cancer cells and other pro-tumorigenic cell types are highly dependent on polyamines for survival, pharmacological modulation of polyamine metabolism is a promising cancer therapeutic strategy. This review covers the roles of polyamines in various cell types of the TME including both immune and stromal cells, as well as how competition for nutrients, namely polyamine precursors, influences the cellular landscape of the TME. It also details the use of polyamines as biomarkers and the ways in which polyamine depletion can increase the immunogenicity of the TME and reprogram tumors to become more responsive to immunotherapy.
Measuring Shame Related to Sexual Orientation: Validation of Sexual Minority—External and Internal Shame Scale (SM-EISS)
Authors: Manão Andreia A. , Seabra Daniel , Salvador Maria do Céu 
Published: May 2024

Abstract
Introduction
Shame is a self-conscious emotion involving negative self-evaluations, being a transdiagnostic factor for psychopathology. Due to stigma and discrimination experiences related to having a minority sexual orientation, LGB+ (lesbian, gay, bisexual, and other minority sexual orientations) people report higher levels of general shame than heterosexual people. To our knowledge, there is no specific measure of shame related to sexual orientation. This study aimed to develop and explore the psychometric properties of the Sexual Minority—External and Internal Shame Scale (SM-EISS) in a sample of Portuguese LGB+ people.

Method
The sample was recruited online between December 2021 and January 2022 and comprised 200 Portuguese LGB+ people (Mage = 27.8 ± 8.9) who completed measures about shame, proximal minority stressors, and mental health.

Results
Good psychometric characteristics were found for a second-order two-factor structure (general, external, and internal shame related to sexual orientation), with the SM-EISS demonstrating good reliability and validity values.

Conclusion
The SM-EISS seems to be a valid and reliable instrument to assess shame related to sexual orientation among LGB+ people and may be beneficial in clinical and research contexts.

Policy Implications
Measuring shame related to sexual orientation experienced by LGB+ people could enhance the clinical understanding of this population. It can help researchers and clinicians to better understand this emotion and how it affects LGB+ people’s mental health and well-being. The research has important implications for clinical practice, social interventions, and public policies to protect LGB+ people’s rights. This is especially relevant in Portugal, where, despite positive legal developments, LGB+ people continue to experience harmful situations that negatively impact their mental health.
Research on pipeline leakage localization method based on CZIM algorithm
Authors: Yue Yuan , Qu Yang , Yan Lei , Wang Zhao , Tang Jun 
Published: May 2024

AbstractThe time difference of arrival is a common method to find the leakage point of water pipeline. The leakage point localization is achieved by calculating the time delay between the signals reaching different sensors. Mainstream time delay estimation algorithms based on signal correlation analysis are susceptible to the introduction of noise signals, low sampling rates, and signal clipping, resulting in inaccurate localization results. The article analyzed the impact of different interference factors and proposed a new time delay estimation algorithm based on signal cross-zero information modulation (CZIM) to address these problems. By normalizing the amplitude of the two signals at the detection points on both sides of the pipeline leakage position, two sets of sparse signal sequences with only two eigenvalues of 0 and 1 are obtained. The error coefficient function is calculated by a similar traversal method to finally index the time delay. In this paper, the principle and characteristics of the algorithm are analyzed and compared with the most commonly used GCC method. In both numerical simulations and actual pipe leakage localization experiments, the CZIM algorithm has shown its wide applicability, low impact by low sampling rate, and adaptability to low signal-to-noise ratios, etc. At the same time, the algorithm is simple in design and has a small amount of calculation and can meet the demand for real-time data processing, providing a new idea for the development of acoustic localization technology.