bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment of cobalamin C (cblC) deficiency during pregnancy
Authors: Brunel‐Guitton Catherine , Costa Teresa , Mitchell Grant A. , Lambert Marie 
Published: September 2010

AbstractObjectiveTo report the successful pregnancy of a woman with methylmalonic acidemia and hyperhomocysteinemia, cblC type [cobalamin C (cblC) deficiency] (MIM 277400).MethodRetrospective chart review.ResultsA 24‐year‐old woman presented at 14 weeks gestation with nausea, self‐restricted protein diet, and weight loss. She had a past history of asymptomatic methylmalonic acidemia but had been lost to follow‐up since the age of 15 years. Biochemical evaluation revealed combined methylmalonic acidemia and hyperhomocysteinemia. Complementation analysis confirmed cblC deficiency. One copy of the most common mutations in the MMACHC gene, c.271dupA, was identified. The women was treated from 15 weeks of gestation with a low protein diet (64 g/day) (1.1 g /kg of weight/day), L‐carnitine (1 g per os 3 times daily to 3 g per os 3 times daily in the third trimester), aspirin (salicylic acid) 80 mg per day, folic acid 5 mg per day, and hydroxocobalamin 1 mg intramuscular every week to two times per week in the third trimester. The pregnancy was uneventful and the delivery at term. The newborn was healthy at delivery and at follow‐up.ConclusionWe report on the successful outcome of pregnancy in a treated woman with cblC disease. The pregnancy was uneventful for both fetus and mother with the delivery of a term healthy boy. There is a need for an international registry on the management and outcomes of pregnancy in women with inborn errors of metabolism.
Dietary Lecithin Source Affects Growth Potential and Gene Expression in Sparus aurata Larvae
Authors: Alves Martins Dulce , Estévez Alicia , Stickland Neil C. , Simbi Bigboy H. , Yúfera Manuel 
Published: September 2010

AbstractSoybean lecithin (SBL), used as a phospholipid source in larval fish diets, may compromise growth and survival in marine species, and affect gene expression, due to differences in fatty acid composition relative to marine lecithins (ML). The potential of SBL as a phospholipid source in gilthead seabream microdiets as compared to ML was evaluated. Two stocking densities were tested in order to exacerbate possible dietary effects: 5 and 20 larvae L−1. Larvae reflected dietary fatty acid profiles: linoleic acid was higher, whereas eicosapentaenoic and arachidonic acids were lower in SBL fed groups than in ML fed larvae. Highest stocking density decreased survival, and led to elevated saturates and lower docosahexaenoic acid levels in polar lipid. Muscle histology observations showed hindered growth potential in SBL fed larvae. Despite similar cortisol levels between treatments, higher glucocorticoid receptor (GR), as well as hormone‐sensitive lipase (HSL) mRNA levels in SBL fed groups revealed a role for fatty acids in gene regulation. Further analysed genes suggested these effects were independent from the hypothalamus‐pituitary‐interrenal axis control and the endocannabinoid system. Cyclooxygenase‐2 and gluconeogenesis seemed unaffected. For the first time in fish, a link between dietary lecithin nature and HSL gene transcription, perhaps regulated through GR fatty acid‐induced activation, is suggested. Enhanced lipolytic activity could partly explain lower growth in marine fish larvae when dietary ML is not provided.
Trypanorhynch cestodes of teleost fish from the Persian Gulf, Iran
Authors: Haseli M. , Malek M. , Valinasab T. , Palm H.W. 
Published: September 2010

AbstractA total of 299 fish belonging to ten teleost species were studied in Iranian waters at the north-eastern coast of the Persian Gulf for larval trypanorhynch cestode infection. The following trypanorhynch species were identified: Callitetrarhynchus gracilis Pintner, 1931, Pseudogilquinia thomasi (Palm, 2000), Pterobothrium lesteri Campbell and Beveridge, 1996 and Pseudolacistorhynchus shipleyi (Southwell, 1929). The most abundant parasite was C. gracilis which was isolated from seven teleost species. The highest prevalence (62.9%) and dominance (0.98) were demonstrated for P. thomasi with a maximum intensity of 22 in Indian halibut Psettodes erumei. Collections of P. lesteri and P. shipleyi from the Persian Gulf represent new locality records, thus extending the known range of distribution for both species. Four new host records are established. The recorded combination of trypanorhynch species and the established host range correspond to other regions, such as off the Brazilian coast. In terms of species distribution, the north-western part of the Indian Ocean, together with the Gulf of Bengal and the Indonesian archipelago, share the same species, resulting from connected water bodies. All trypanorhynch species were isolated from the body cavity, except for P. thomasi which was recorded from the musculature of P. erumei. Relatively high intensities of infection in P. erumei may be of public health concern in the region, necessitating the consumption of well-cooked fish products.
Transitional Justice and Victims' Rights before the End of a Conflict: The Unusual Case of Colombia
Authors: GARCÍA-GODOS JEMIMA , LID KNUT ANDREAS O. 
Published: September 2010

AbstractIn a context of continuing armed conflict, a comprehensive scheme of transitional justice has been developed in Colombia since 2005 through the Law of Justice and Peace, with the aim of achieving peace with one of the armed actors in the conflict, the paramilitary groups. The clear link between the demobilisation of illegal armed groups and the rights of the victims is the main feature of the Colombian process. This article provides a systematic review of the implementation of the law, focusing on the institutions, mechanisms and procedures put in place to fulfil its goals. Emphasis is given to the legal category of ‘victim’, victims' rights and victim reparation measures. By exploring how the scheme works in principle and in practice, we are able to assess the prospects for victims' rights in Colombia today.
US Labour and Management Fight It Out in Post-1954 Guatemala
Authors: BROCKETT CHARLES D. 
Published: September 2010

AbstractThe differing perspectives and actions of US government, business and labour towards the Guatemalan government and Guatemalan trade unionists themselves in the half-decade or so following the overthrow of the Arbenz administration in 1954 are the focus of this study. Few areas were more important to the US project for Guatemala following the Castillo Armas invasion than helping the Guatemalans to create a ‘free’ and ‘democratic’ labour movement – and few areas would prove more frustrating. Part of the problem was the intransigent stance of Guatemalan elites. An additional challenge was strong opposition from the major US-based companies operating in Guatemala, most notably the United Fruit Company and its affiliates. This work contests interpretations that regard US policy towards countries like Guatemala at the time as simply beholden to business interests or as seeking domination. Rather, as Washington's interest in the transition diminished, officials in the US embassy and representatives of US labour in Guatemala were left isolated, unable to fulfil their vision for a democratic labour movement in the teeth of such opposition.
Agrarian Reform and Revolutionary Justice in Soconusco, Chiapas:Campesinosand the Mexican State, 1934–1940
Authors: NOLAN-FERRELL CATHERINE 
Published: September 2010

AbstractDuring the mid- to late 1930s, rural activism surged in the coffee-growing region of southern Chiapas and north-western Guatemala. This article examines the causes and impacts of sustained campesino protests at the grassroots level on the Mexican side of the border. The porous border between the two nations hindered the development of centralised power networks that prevailed in other parts of Chiapas. Campesinos and reformist federal government officials such as teachers and agrarian engineers built alliances that challenged the power of the coffee growers. This article explores the process of negotiation that occurred among campesinos, federal bureaucrats, regional authorities and elite coffee planters in order both to implement and to challenge agrarian reform.
Anthelmintic resistance: markers for resistance, or susceptibility?
Authors: BEECH R. N. , SKUCE P. , BARTLEY D. J. , MARTIN R. J. , PRICHARD R. K. , GILLEARD J. S. 
Published: September 2010

SUMMARYThe Consortium for Anthelmintic Resistance and Susceptibility (CARS) brings together researchers worldwide, with a focus of advancing knowledge of resistance and providing information on detection methods and treatment strategies. Advances in this field suggest mechanisms and features of resistance that are shared among different classes of anthelmintic. Benzimidazole resistance is characterized by specific amino acid substitutions in beta-tubulin. If present, these substitutions increase in frequency upon drug treatment and lead to treatment failure. In the laboratory, sequence substitutions in ion-channels can contribute to macrocyclic lactone resistance, but there is little evidence that they are significant in the field. Changes in gene expression are associated with resistance to several different classes of anthelmintic. Increased P-glycoprotein expression may prevent drug access to its site of action. Decreased expression of ion-channel subunits and the loss of specific receptors may remove the drug target. Tools for the identification and genetic analysis of parasitic nematodes and a new online database will help to coordinate research efforts in this area. Resistance may result from a loss of sensitivity as well as the appearance of resistance. A focus on the presence of anthelmintic susceptibility may be as important as the detection of resistance.
Diatom-associated bacteria are required for aggregation of Thalassiosira weissflogii
Authors: Gärdes Astrid , Iversen Morten H , Grossart Hans-Peter , Passow Uta , Ullrich Matthias S 
Published: September 2010

Abstract
Aggregation of algae, mainly diatoms, is an important process in marine systems leading to the settling of particulate organic carbon predominantly in the form of marine snow. Exudation products of phytoplankton form transparent exopolymer particles (TEP), which acts as the glue for particle aggregation. Heterotrophic bacteria interacting with phytoplankton may influence TEP formation and phytoplankton aggregation. This bacterial impact has not been explored in detail. We hypothesized that bacteria attaching to Thalassiosira weissflogii might interact in a yet-to-be determined manner, which could impact TEP formation and aggregate abundance. The role of individual T. weissflogii-attaching and free-living new bacterial isolates for TEP production and diatom aggregation was investigated in vitro. T. weissflogii did not aggregate in axenic culture, and striking differences in aggregation dynamics and TEP abundance were observed when diatom cultures were inoculated with either diatom-attaching or free-living bacteria. The data indicated that free-living bacteria might not influence aggregation whereas bacteria attaching to diatom cells may increase aggregate formation. Interestingly, photosynthetically inactivated T. weissflogii cells did not aggregate regardless of the presence of bacteria. Comparison of aggregate formation, TEP production, aggregate sinking velocity and solid hydrated density revealed remarkable differences. Both, photosynthetically active T. weissflogii and specific diatom-attaching bacteria were required for aggregation. It was concluded that interactions between heterotrophic bacteria and diatoms increased aggregate formation and particle sinking and thus may enhance the efficiency of the biological pump.
Prevention of diabetic nephropathy in Ins2+/−AkitaJ mice by the mitochondria-targeted therapy MitoQ
Authors: Chacko Balu K. , Reily Colin , Srivastava Anup , Johnson Michelle S. , Ye Yaozu , Ulasova Elena , Agarwal Anupam , Zinn Kurt R. , Murphy Michael P. , Kalyanaraman Balaraman , Darley-Usmar Victor 
Published: September 2010

Mitochondrial production of ROS (reactive oxygen species) is thought to be associated with the cellular damage resulting from chronic exposure to high glucose in long-term diabetic patients. We hypothesized that a mitochondria-targeted antioxidant would prevent kidney damage in the Ins2+/−AkitaJ mouse model (Akita mice) of Type 1 diabetes. To test this we orally administered a mitochondria-targeted ubiquinone (MitoQ) over a 12-week period and assessed tubular and glomerular function. Fibrosis and pro-fibrotic signalling pathways were determined by immunohistochemical analysis, and mitochondria were isolated from the kidney for functional assessment. MitoQ treatment improved tubular and glomerular function in the Ins2+/−AkitaJ mice. MitoQ did not have a significant effect on plasma creatinine levels, but decreased urinary albumin levels to the same level as non-diabetic controls. Consistent with previous studies, renal mitochondrial function showed no significant change between any of the diabetic or wild-type groups. Importantly, interstitial fibrosis and glomerular damage were significantly reduced in the treated animals. The pro-fibrotic transcription factors phospho-Smad2/3 and β-catenin showed a nuclear accumulation in the Ins2+/−AkitaJ mice, which was prevented by MitoQ treatment. These results support the hypothesis that mitochondrially targeted therapies may be beneficial in the treatment of diabetic nephropathy. They also highlight a relatively unexplored aspect of mitochondrial ROS signalling in the control of fibrosis.
Stochastic models for large interacting systems and related correlation inequalities
Authors: Liggett Thomas M. 
Published: September 2010

A very large and active part of probability theory is concerned with the formulation and analysis of models for the evolution of large systems arising in the sciences, including physics and biology. These models have in their description randomness in the evolution rules, and interactions among various parts of the system. This article describes some of the main models in this area, as well as some of the major results about their behavior that have been obtained during the past 40 years. An important technique in this area, as well as in related parts of physics, is the use of correlation inequalities. These express positive or negative dependence between random quantities related to the model. In some types of models, the underlying dependence is positive, whereas in others it is negative. We give particular attention to these issues, and to applications of these inequalities. Among the applications are central limit theorems that give convergence to a Gaussian distribution.
Feeding ecology of the southern lanternshark (Etmopterus baxteri) and the brown lanternshark (E. unicolor) off southeastern Australia
Authors: Hallett Chris S. , Daley Ross K. 
Published: September 2010

Abstract
Hallett, C. S., and Daley, R. K. 2011. Feeding ecology of the southern lanternshark (Etmopterus baxteri) and the brown lanternshark (E. unicolor) off southeastern Australia. – ICES Journal of Marine Science, 68: 157–165. Little is known about the ecological interactions between bycatch species and orange roughy (Hoplostethus atlanticus) within exploited slope and seamount communities off Tasmania. The diet of Etmopterus baxteri and E. unicolor, two important bycatch species of these fisheries, is described using four indices [percentage frequency of occurrence, percentage by number, percentage by weight, and percentage by the index of relative importance (%IRI)] calculated for broad prey categories, individual prey taxa, and functional prey groups. The identifiable diet of E. unicolor was dominated by benthic cephalopods (96%IRI), whereas benthic teleost prey, notably orange roughy (43%IRI), dominated the diet of E. baxteri. Similar trophic mechanisms appear to support aggregations of orange roughy and Etmopterus spp. off Tasmania; they feed on demersal species and mesopelagic or vertically migrating nekton advected laterally onto the mid-slope. The importance of teleost prey in the diet of E. baxteri apparently increases with shark length, whereas crustaceans become less important, which is a similar diet shift to that of orange roughy. Etmopterus baxteri is both a potential competitor and predator of orange roughy in these ecosystems. Fishery managers need to understand and consider the complex trophic interactions between orange roughy, sharks, and other exploited species in managing recently reopened deep-water fisheries off southeastern Australia.
Identification of Putative Stage-Specific Grapevine Berry Biomarkers and Omics Data Integration into Networks
Authors: Zamboni Anita , Di Carli Mariasole , Guzzo Flavia , Stocchero Matteo , Zenoni Sara , Ferrarini Alberto , Tononi Paola , Toffali Ketti , Desiderio Angiola , Lilley Kathryn S. , Pè M. Enrico , Benvenuto Eugenio , Delledonne Massimo , Pezzotti Mario 
Published: September 2010

Abstract
The analysis of grapevine (Vitis vinifera) berries at the transcriptomic, proteomic, and metabolomic levels can provide great insight into the molecular events underlying berry development and postharvest drying (withering). However, the large and very different data sets produced by such investigations are difficult to integrate. Here, we report the identification of putative stage-specific biomarkers for berry development and withering and, to our knowledge, the first integrated systems-level study of these processes. Transcriptomic, proteomic, and metabolomic data were integrated using two different strategies, one hypothesis free and the other hypothesis driven. A multistep hypothesis-free approach was applied to data from four developmental stages and three withering intervals, with integration achieved using a hierarchical clustering strategy based on the multivariate bidirectional orthogonal projections to latent structures technique. This identified stage-specific functional networks of linked transcripts, proteins, and metabolites, providing important insights into the key molecular processes that determine the quality characteristics of wine. The hypothesis-driven approach was used to integrate data from three withering intervals, starting with subdata sets of transcripts, proteins, and metabolites. We identified transcripts and proteins that were modulated during withering as well as specific classes of metabolites that accumulated at the same time and used these to select subdata sets of variables. The multivariate bidirectional orthogonal projections to latent structures technique was then used to integrate the subdata sets, identifying variables representing selected molecular processes that take place specifically during berry withering. The impact of this holistic approach on our knowledge of grapevine berry development and withering is discussed.
Calcinosis cutis in systemic lupus erythematosus: A case report and review of the published work
Authors: KIM Min Sung , CHOI Kyu Chul , KIM Hyun Sook , SONG In Guk , SHIN Bong Seok 
Published: September 2010

AbstractCalcinosis cutis is a common clinical feature of dermatomyositis and scleroderma but rarely reported in association with systemic lupus erythematosus (SLE). Calcinosis cutis in SLE occurs without calcium and phosphorus metabolic abnormalities and may be localized or generalized. The pathophysiology remains unclear and no effective therapy is currently available. We report a 30‐year‐old woman with a 13‐year history of SLE who developed multiple calcinosis cutis around both knees and we review the relevant published work.
In vitro and in vivo effects of the Mongolian drug Amu‐ru 7 on Helicobacter pylori growth and viability
Authors: Bai Cui Lan , Osaki Takako , Yonezawa Hideo , Hanawa Tomoko , Zaman Cynthia , Kurata Satoshi , Kamiya Shigeru , Tanaka Hideyuki 
Published: September 2010

ABSTRACTAmu‐ru 7, a Mongolian folk medicine, is used to treat digestive diseases such as gastritis and gastric and duodenal ulcers. We examined the effect of Amu‐ru 7 on the growth and viability of Helicobacter pylori in vivo and in vitro. By the agar dilution method, the MIC of Amu‐ru 7 for H. pylori strains was shown to be 100–200 μg/mL with a MIC90 of 200 μg/mL. Two hundred micrograms per milliliter of Amu‐ru 7 exhibited potent bactericidal activity against H. pylori in the stationary phase of growth 6 hr after treatment. Amu‐ru 7 inhibited the growth of both AMPC‐resistant and CAM‐resistant strains, and also had a combined effect with AMPC on AMPC‐resistant strain 403. The Amu‐ru 7 inhibited biofilm formation by H. pylori and induced morphological changes, such as bleb‐like formation and shortening of the cell. Although colonization of the stomach of the Mongolian gerbil by H. pylori was not cured by treatment with Amu‐ru 7, both the mean number of H. pylori colonized and the colonization rate were decreased in Amu‐ru 7 treated gerbils. These results suggest the effectiveness Amu‐ru 7 as an adjunct therapy for eradication therapies consisting of a PPI combined with antibiotics.
Modelling the resource implications of managing adults with Fabry disease in Norway favours home infusion
Authors: Guest Julian F. , Jenssen Trond , Houge Gunnar , Aaseboe Willy , Tøndel Camilla , Svarstad Einar 
Published: September 2010

Eur J Clin Invest 2010; 40 (12): 1104–1112AbstractBackground  The aim of this study was to estimate the resource implications and budget impact of managing adults with Fabry disease in Norway, from the perspective of the publicly funded healthcare system.Methods  A decision model was constructed using published clinical outcomes and clinician‐derived resource utilization estimates. The model was used to estimate the annual healthcare cost of managing a cohort of 64 adult Fabry patients in an average year.Results  The expected annual cost of managing 60 existing Fabry patients and four new patients in Norway each year was estimated to be NOK 55·8 million (€6·7 million). In an average year, patients receiving enzyme replacement therapy (ERT) with agalsidase alfa (Replagal®) at 0·2 mg kg−1 or agalsidase beta (Fabrazyme®) at 1·0 mg kg−1 are collectively expected to make 586 attendances to their family practitioner’s office for their infusions, which equates to 128 eight‐hour days associated with ERT. Encouraging more patients to undergo home‐based infusions has substantial potential to free‐up community‐based resources. In comparison, the community‐related benefit that can be obtained by switching from agalsidase beta (1·0 mg kg−1) to agalsidase alpha (0·2 mg kg−1) is marginal, and dependent on the two doses being clinically equivalent.Conclusion  Maximizing the proportion of adults with Fabry disease undergoing home‐based infusions has the potential to release community‐based resources for alternative use by non‐Fabry patients, thereby improving the efficiency of the publicly funded healthcare system in Norway.