bluuebunny/crossref_metadata_2025_split huggingface dataset:
La era de la ebullición global: Desafíos y oportunidades para la resiliencia climática en la región centroamericana
Authors: Rojas  Morales José Rodrigo 
Published: June 2024

[Introduction]: In July 2023 was announced the end of planetary warming and the beginning of the era of the global boiling. A climatic anomaly whose unprecedented, aggressiveness will hit the Central American region. [Methodology]: Through technological surveillance tools and data analytics, this study shows a series of challenges and opportunities to meet this threat and move towards resilient regional performance. [Results]: All countries have signed agreements and declaratory public policies for the climate resilience, however historical failures persist as well environmental passives to reduce greenhouse gas emissions and the strong dependence for the use of fossil energy. In contrast, Central America enjoys a matrix of opportunities to increase the climatic ambition, also a diverse mix of renewable energy sources, environmental pay mechanisms and actions to impulse circular economy and the bioeconomy [Conclusions]: The regional agenda fail in connect to a climate shielding to respond the rigors of the boiling era. Regarding those balances, and the scientific evidence, a road map, with climate smart and socially inclusive actions, is proposed. [Recommendations]: For the monitoring, research, and education programs on the boiling era, a regional observatory, on climate resilience (OR2C), is recommended.
Stress modulation strategies in Kluyveromyces marxianus: Unravelling the effects of shear force and aeration for enhanced specific ergosterol production
Authors: Vidra A. , Németh Á. 
Published: June 2024

AbstractErgosterol, as a precursor for synthesising useful molecules like vitamin D2, possesses significant physiological functions in both fungal and human systems. In fungi, ergosterol plays a crucial role in stress responses. In contrast to Saccharomyces cerevisiae yeast, the changes in specific ergosterol content of Kluyveromyces marxianus under various stress conditions are less known. This study investigated how ergosterol content changes in response to different stress factors. Carbon to nitrogen (C/N) ratio was examined using experimental design. The effects of aeration and shear force beside constant overall volumetric mass transfer coefficient (KLa) were examined. Cell growth and specific ergosterol content were investigated using ethanol stress during a two-stage fermentation. Based on the results, contradictory settings regarding C/N ratio and shear force were found to be favourable for cell growth and specific ergosterol content. However, increased aeration consistently elevated specific ergosterol content and favoured cell growth as well (2.5-fold and 1.5-fold, respectively). In K. marxianus fermentations, higher ergosterol yield can be achieved through a two-stage fermentation (138.9 mg L−1 compared to 52.9 mg L−1), where the first stage provides favourable conditions for cell growth, and the second stage involves stress (beneficial for ergosterol production) conditions. Conclusions drawn from the two-stage fermentation results suggest that early transitioning of cell growth to the second phase will not result higher adaption and specific ergosterol content compared to the transition at the end of exponential growth phase.
Investigation of approaches to designing complex database structures in systems of integrated monitoring of environmental, economic, energy and social parameters of the territory
Authors: Slipchenko Volodymyr , Poliahushko Liubov , Krush Olha , Rudyk Volodymyr 
Published: June 2024

The object of research is the traditional and universal approach of designing the database structure in systems of integrated monitoring of ecological, economic, energy and social parameters of the territory, which include diverse data from various subject areas. In the course of the study, an analysis was performed based on a set of criteria such as scalability, ease of updating data, absence of empty fields, volume of the database, number of tables and fields, ease and speed of execution of requests for a sample set of indicators of the research object. The comparison of these approaches took place on the example of water resources monitoring, since it has several subsystems and a large number of indicators that are used for assessment. It is established that the proposed universal approach to designing complex database structures made it possible to reduce the volume of the database by 2.25 times due to the absence of empty fields. In particular, in the considered example, the filling factor of the database with the traditional approach is 1.75 times less than with the proposed universal approach. It should be noted that the rate of table filling for the traditional design approach can vary depending on the number of indicator values, while the table filling rate for the universal approach is always close to 100 %. Also, the proposed database design approach makes it possible to speed up data loading and processing. For example, with the same volume of significant information, the minimum speed of sampling the characteristics of one research object is 3.87 times greater in a database developed according to the principles of the universal approach than according to the rules of the traditional approach. The proposed structure of the database is successfully used in the system of complex eco-energy-economic monitoring. The developed structure of the database can serve as an effective basis for the formation of an electronic data bank at the level of the enterprise, region and country.
Preaching the Word of God in the Polish synodal synthesis
Authors: Szewczyk Leszek 
Published: June 2024

Launched in the Catholic Church by Pope Francis on October 10, 2021, the Synod on Synodality is entering the next stages. Continental syntheses have already been published, preceded by diocesan and national syntheses. The nationwide synodal synthesis and individual diocesan surveys are valuable sources containing numerous opinions on the state of preaching the Word of God in Poland. Despite the noticeable lack of theological references, Polish syntheses are important for the theory and practice of preaching the Word of God. The syntheses were prepared based on the opinions of 65,000 people participating in parish and diocesan meetings and 42 thousand people who responded to surveys and written correspondence. This study aimed to extract from the syntheses mentioned above issues concerning the nature of the homily and its position in the liturgy, the preacher of the Word of God, the general assessment of preaching in Poland, as well as the assessment of the content and form of homily preaching. However, the opinions and proposals contained in the syntheses should be the subject of further, in-depth research in the theology of preaching the Word of God.
Preparing a homily as an important element of pastoral care
Authors: Sławiński Henryk 
Published: June 2024

The homily, which the Second Vatican Council assigned a special role among various forms of preaching the Word of God, is an important task for those, who are entrusted with pastoral care. The faithful eagerly listen to homilies, but at the same time, they often complain that their level is too low and expect homilies on the good level. Yet, the solution to the problem lies in good preparation of the homily. Also, preachers must be convinced that the time allocated for this is one of their most important pastoral duties. We have evidence of how the last popes, Benedict XVI and Francis, prepared their homilies. Working on a sermon is a creative process that goes through the following phases: research and collection of materials, incubation, illumination, and verification. The fruit of reflection and prayer is a homily characterized by Christocentrism, a positive message from which a moral call arises; it contains the teaching of the Church, actualizes the word of God, introduces the celebrated liturgy, and is single-thematic. Hence, in the pastors’ belief in the important role of the sermon and its reliable preparation, there is an opportunity to improve the quality of the homily.
The truth about man and for man. Practical implications of John Paul II’s encyclical “Fides et ratio”
Authors: Hajduk Ryszard 
Published: June 2024

Twenty-five years ago, John Paul II’s encyclical Fides et ratio was published, where the question of truth occupies a central place. The task of the Church is to transmit to people the truth revealed by Jesus Christ, which discloses the mystery of God and man, is accessible in faith, and appeals to the intellect to accept it. In these times, dominated by a pragmatic approach to reality, a question arises about the practical, existential meaning of the truth proclaimed by the Church. The content analysis of the papal teaching in “Fides et ratio” leads to the conclusion that the truth cannot be reduced to a set of ideas that enrich human cognition. Therefore, the ecclesial ‘diakonia’ of truth serves human life because it helps man use his freedom properly and leads him to the fullness of humanity. The truth allows man to protect himself from relativism and religious egalitarianism threats. The communication of truth should consider people’s needs to perceive it as a precious gift from God, not as a yoke.
The nomination of Rev. Kazimierz Rolewski as bishop of Katowice and the reasons for the refusal
Authors: Szczepaniak Maciej 
Published: June 2024

Rev. Kazimierz Rolewski (1887–1936) — parish priest in the Archdiocese of Poznań, rector of the theological seminary, and radio preacher — remains an inspiring figure to this day, as evidenced by the ongoing beatification process. Many people remember him as a priest who refused to accept the episcopal nobleness. This article refers to this common opinion in light of the Vatican archives. It is an attempt to highlight the important character traits of the discussed figure, especially his humility and sincerity. Based on the source analysis method, the article presents facts about Rev. Rolewski before and after the proposal to take over the bishopric of Katowice. This article presents the genesis of the interest in the parish priest from Ostrów Wielkopolski as a candidate for the diocesan bishop in 1925–1926. It describes the circumstances of the negative decision made at the apostolic nunciature in Warsaw. The above piece, which attempts to highlight the character traits important for the discussed character — his humility and honesty — fills the current biographical gap of Rev. Rolewski.
Activity of oxidative processes and the state of the redox regulating system in tumor tissue in skin cancer
Authors: Goroshinskaya I. A. , Frantsiyants E. M. , Larina N. I. , Przhedetskiy Yu. V. , Kaplieva I. V. , Nemashkalova L. A. , Bandovkina V. A. , Pozdnyakova V. V. , Przhedetskaya V. Yu. 
Published: June 2024

Purpose of the study. To study the intensity of lipid peroxidation (LPO) and the activity of antioxidant protection components in tumor tissues, peritumoral zone and conditionally healthy skin tissue in basal cell carcinoma, depending on the type of tumor growth, gender of patients, and the presence of concomitant diseases.Materials and methods. Tissues from 34 patients with basal cell carcinoma (BCC) were studied, including 17 women (10 with superficial tumor growth and 7 with solid growth) and 17 men (5 and 12 patients, respectively). We used skin flaps obtained during operations on 12 men and 10 women without malignant pathology (“norm”) as a comparison material. The content of malondialdehyde (MDA), diene conjugates (DC), superoxide dismutase (SOD) activity and total peroxidase activity (TPA) were determined. Statistical processing of the results was carried out using the Statistica 10.0 program.Results. In women, the level of MDA was increased in all tissues: with superficial growth of BCC by 2.1–2.5 times (p ≤ 0.05), with solid growth by 1.6–2.1 times (p < 0.05) relative to the “norm”. In men with superficial growth, an MDA increase by 3.2 and 3.1 times in tumor tissue and conditionally healthy tissue was observed (p < 0.02), and no increase in MDA in the tumor was detected in 11 of 12 patients with solid growth. An increase in DC (on average 2–5 times) in BCC patients with concomitant hypertension and diabetes mellitus was observed mainly in women. Activation of SOD in tumor tissue, to a greater extent in men (2.4 times with superficial growth and 1.7 times with solid growth, p < 0.05 relative to conditionally healthy tissue), can be considered as a mechanism of antiradical protection of the tumor.Conclusions. An increase in the level of MDA in BCC was observed in tumor and nearby tissues in women with both types of growth, in men only with superficial growth. Analysis of individual characteristics of LPO indicators in patients with skin carcinoma revealed a dependence of the severity of the increase in MDA and especially DC on the presence of concomitant pathology (hypertension, diabetes mellitus).
Predictive model for determining the indications for automated 3D ultrasound for screening patients at low risk of developing breast tumors
Authors: Garanina A. E. , Kholin A. V. 
Published: June 2024

Automatic ultrasound examination of the breast (3D ultrasound) has become an important tool in the diagnosis of breast cancer. It is believed that 3D ultrasound has high reproducibility, low dependence on the operator, less time spent on obtaining images, and automatic three-dimensional reconstruction of the entire breast.Purpose of the study. To develop indications for 3D ultrasound based on predictive screening models for patients with a low risk of developing breast tumors based on the identification of the most significant risk factors.Patients and methods. A retro-prospective clinical study has been conducted from February 2019 to May 2023. A total of 2794 patients were included in the study. All patients underwent clinical examination, palpation, collected information on socio-demographic data and potential risk factors for breast cancer, and 2D ultrasound was also performed. The group under the age of 40 included 1,511 patients, of whom 628 underwent 3D ultrasound. The sample of 40 years and older included 1,283 patients, 655 of whom underwent 3D ultrasound. Mammography was performed in patients aged 40 and older. Quantitative and qualitative indicators of anamnesis and clinical examination, as well as MMH results in patients over 40 years old, were recorded. Based on these data, a logistic regression was compiled, followed by the selection of the most significant model by cutting off insignificant factors according to the p-level of significance and presenting the model as a ROC curve.Results. The most significant risk factors for the detection of breast cancer were identified. Based on their screening with 3D ultrasound in a group up to 40 years of age, it can be used in 95.96 % and is not indicated in 4.04 %. The presented model in the group up to 40 years worked correctly in 99.21 %. While screening with 3D ultrasound in a group of 40 years and older in 84.26 % is appropriate and not indicated in 15.74 %. The presented model worked correctly in 97.12 %.Conclusion. The study identified important pre-diagnostic factors for the choice of a diagnostic algorithm for breast examination in women of different age groups, and determined the indications for 3D ultrasound. The developed algorithms will help optimize screening and referral for additional examinations, which is of practical importance for improving diagnostics and optimizing healthcare resources.
The role of immunotherapy in the treatment of skin melanoma: a contemporary perspective
Authors: Masaeva P. S. 
Published: June 2024

Purpose of the study. To evaluate the role and possibilities of various types of immunotherapy in the treatment of skin melanoma, as well as the prospects for its use in clinical practice.Materials and methods. The literature was looked up in the PubMed database. Publication date limit was set from 2018 to 2023. The following keywords were used as search queries: "Melanoma", "Melanoma and immunotherapy", "Treatment of Metastatic Melanoma", "Immunological Factors". Full-text versions were selected. Articles that were based on the subjective opinion of the authors were excluded from the study. For each research found, the following parameters were recorded: treatment method, number of patients, follow-up period, time of relapse-free course, survival rate. No meta-analysis of the data was performed due to the high heterogeneity of the studies. Results. A sufficiently high efficiency of adjuvant therapy with inhibitors of immune response control points in the treatment of BRAF-negative patients has been noted. For this reason, the drug ipilimumab, which appeared among the first, demonstrated its effectiveness. The drug nivolumab gave, according to one of the studies, a 5‑year overall survival rate of 35 %. The use of pembrolizumab was associated with a 5‑year overall survival rate of 41 %. In the 2015 meta-analysis It has been demonstrated that the use of nivolumab, as well as pembrolizumab, provides the best overall survival, and therefore can be included in first-line therapy. The combination of these drugs makes it possible to achieve a good response to therapy in patients with BRAF-positive status (5‑year overall survival rate of 52 %).Conclusion. Melanoma immunotherapy with immune response checkpoint inhibitors is currently the most effective treatment method, especially in cases where it complements surgical resection of the tumor. The most commonly used drugs are nivolumab and ipilimumab, which work more effectively when combined. Thus, the 5‑year progression-free survival rate is 36 %, the overall survival rate is 52 %. Resistance to immunotherapy is an important problem of this type of treatment, the solution of which will help to improve the outcomes of control over the local cancer process and improve the response to therapy. It is possible to find a solution to this problem due to the fundamental study of the molecular biology of the tumor in terms of modeling tumor growth and tumor "escape" mechanisms.
STUDENTS’ ERRORS IN PROBLEM-SOLVING REVIEWED FROM THE PERSPECTIVE OF MATH RESILIENCE
Authors: Utami Wikan Budi , Dewi Aulia Puspita , Widodo Sri Adi 
Published: June 2024

<p>The purpose of this research is to: 1) identify students' mistakes in solving mathematical problems in trigonometry in terms of mathematical resilience according to the Newman Procedure, and 2) discuss trigonometric problems from the point of view of mathematical resilience according to the Newman Procedure. This type of research is qualitative. The research subjects were 3 students from SMA Negeri 1 Slawi, selected using a purposive sampling technique. The methods of data collection are tests, questionnaires, interviews, and documentation. The data analysis techniques used are data reduction, data presentation, and drawing conclusions. Based on the results of the data analysis, we obtained the following: (1) Students' mistakes in reading the questions include: students do not understand the context of the sentence, students do not correctly understand the meaning, and students do not read all the meanings of the desired words. (2) The answers to the questions include: answers that do not contradict the accepted answers but do not coincide with the inquiry accepted in the question, and answers that do not address what is required in the problem posed, often being a question of application. (3) Transforming the problem includes: considering a method being investigated, using the wrong method, and not translating the method to be used. (4) Process skills contain: concept errors, errors in computing, not continuing the settlement procedure, and not processing calculations. (5) The final answer includes: an answer that fits the context of the question, and an answer that does not match the conclusion. The contributing factors include: lack of self-confidence, confusion in describing the problem in the form of a picture, hurrying in solving problems, lack of accuracy, inability to manage time well, inability to think about problems thoroughly, forgetting to identify what is suitable and trying, confusion in determining the formula to be used, and solving the problem without completing the conclusion.</p>
FINANCIAL LITERACY, INFORMALITY, AND SMALL BUSINESS OPERATIONAL PERFORMANCE IN ZIMBABWE
Authors: Taruvinga Rutendo , Sakarombe Upenyu 
Published: June 2024

Introduction: The exponential growth of small and medium enterprises (SMEs) in many developing economies is a well-documented phenomenon in business literature. However, research indicates that the expansion of most SMEs is hindered by financial illiteracy and high levels of informality, posing significant challenges to their performance and long-term sustainability. Concerns arise from the fact that only a small fraction of these enterprises successfully transition into larger firms. This study sought to address these issues by investigating the levels of financial literacy among 120 SMEs operating in Harare and Bindura, taking into account the pervasive informality within the sector. The research also aimed to evaluate the relationship between financial literacy and SME operational performance.
Methods: Employing a quantitative approach within an explanatory research design, data collection was facilitated through a structured questionnaire. To capture the diverse landscape of SMEs operating in an informal context, both purposive and convenience sampling methods were utilized to select participants for the survey. Descriptive and inferential analyses were conducted using SPSS software.
Results: The findings of the study revealed a significant positive impact of financial literacy on SME operational performance, indicating that advanced financial literacy can contribute to enhanced business outcomes. Moreover, the research observed an improvement in financial literacy within SME operations, evidenced by increased awareness and application of financial management skills.
Conclusion and suggestion: The study recommends that efforts to promote financial literacy among SMEs should be intensified through advanced financial education initiatives, awareness campaigns, and enhanced financial inclusion strategies. Financial service providers are encouraged to play a proactive role in supporting SME growth by investing in financial awareness programs, funding educational initiatives, and actively engaging SMEs in key economic policy frameworks. Ultimately, SMEs are urged to fully embrace financial literacy as a fundamental pathway for achieving sustainable growth and long-term business success amidst the challenges of informality.
Experiential Marketing and Quality Drive Coffee Shop Loyalty in Indonesia
Authors: Kushenda Dimas Ardyadheva , Hariasi Misti 
Published: June 2024

This study analyzes the effects of Experiential Marketing, Product Quality, and Service Quality on consumer loyalty at a coffee shop in Pandaan. Using an associative quantitative approach, data from 100 consumers were collected via questionnaires and processed with SPSS. Results indicate that all three factors positively and significantly impact consumer loyalty. These findings suggest that improving these aspects can enhance customer loyalty. The study fills a knowledge gap by providing empirical evidence on the importance of experiential marketing, product quality, and service quality in the coffee shop industry.
Highlight:

Experiential Marketing positively impacts consumer loyalty.
High product quality boosts customer retention.
Excellent service quality enhances repeat purchases.

Keywoard: Experiential Marketing, Product Quality, Service Quality, Consumer Loyalty, Coffee Shop