bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epoetin alpha decreases the number of erythrocyte transfusions in patients with acute lymphoblastic leukemia, lymphoblastic lymphoma, and Burkitt leukemia/lymphoma
Authors: Cabanillas Maria E. , Kantarjian Hagop , Thomas Deborah A. , Mattiuzzi Gloria N. , Rytting Michael E. , Bruera Eduardo , Xiao Lianchun , Bekele B. Nebiyou , Foudray Maria C. , Cortes Jorge E. 
Published: July 2011

AbstractBACKGROUND:Anemia is an expected consequence of intensive chemotherapy regimens administered to patients with acute leukemia. This study was designed to determine whether epoetin alpha would decrease the number of transfusion events and units of packed erythrocytes (PRBCs) transfused, and the secondary objective was to study the effects of epoetin alpha on quality of life (QOL) and complete remission (CR) rates.METHODS:Patients with acute lymphoblastic leukemia (ALL), lymphoblastic lymphoma (LL), or Burkitt lymphoma (BL) who were receiving frontline myelosuppressive chemotherapy were randomized to receive epoetin alpha or no epoetin during the first 6 cycles of their planned chemotherapy. QOL was assessed by using the Edmonton Symptom Assessment Scale (ESAS) and the Functional Assessment of Cancer Therapy (FACT)‐Anemia questionnaires.RESULTS:Fifty‐five patients were randomized to receive epoetin alpha, and 54 patients received no epoetin. Transfusion data were available for 79 of 81 evaluable patients (98%) who completed the treatment/observation period. The trial was stopped early because of poor accrual before the target of 123 evaluable patients was met. A mean of 10.6 units of PRBCs over 5 months were administered to those who received epoetin alpha compared with 13 units for those who did not receive epoetin (P = .04). There was no significant difference in QOL as assessed by the FACT‐Anemia or ESAS instruments. The CR rate and the 3‐year CR duration were not affected adversely by use of epoetin alpha.CONCLUSIONS:Epoetin alpha decreased the number of PRBC transfusions and did not appear to have a negative impact on remission duration. No difference in QOL was observed. Cancer 2012;. © 2011 American Cancer Society.
Partial differential equation transform—Variational formulation and Fourier analysis
Authors: Wang Yang , Wei Guo‐Wei , Yang Siyang 
Published: July 2011

SUMMARYNonlinear partial differential equation (PDE) models are established approaches for image/signal processing, data analysis, and surface construction. Most previous geometric PDEs are utilized as low‐pass filters, which give rise to image trend information. In an earlier work, we introduced mode decomposition evolution equations (MoDEEs), which behave like high‐pass filters and are able to systematically provide intrinsic mode functions (IMFs) of signals and images. Because of their tunable time–frequency localization and perfect reconstruction, the operation of MoDEEs is called a PDE transform. By appropriate selection of PDE transform parameters, we can tune IMFs into trends, edges, textures, noise, and so forth, which can be further utilized in the secondary processing for various purposes. This work introduces variational formulation, performs the Fourier analysis, and conducts biomedical and biological applications of the proposed PDE transform. The variational formulation offers an algorithm to incorporate two image functions and two sets of low‐pass PDE operators in the total energy functional. Two low‐pass PDE operators have different signs, leading to energy disparity, while a coupling term, acting as a relative fidelity of two image functions, is introduced to reduce the disparity of two energy components. We construct variational PDE transforms by using Euler–Lagrange equation and artificial time propagation. Fourier analysis of a simplified PDE transform is presented to shed light on the filter properties of high‐order PDE transforms. Such an analysis also offers insight on the parameter selection of the PDE transform. The proposed PDE transform algorithm is validated by numerous benchmark tests. In one selected challenging example, we illustrate the ability of PDE transform to separate two adjacent frequencies of sin (x) and sin(1.1x). Such an ability is due to PDE transform's controllable frequency localization obtained by adjusting the order of PDEs. The frequency selection is achieved either by diffusion coefficients or by propagation time. Finally, we explore a large number of practical applications to further demonstrate the utility of the proposed PDE transform. Copyright © 2011 John Wiley & Sons, Ltd.
Near‐Infrared Fluorescent Sensors based on Single‐Walled Carbon Nanotubes for Life Sciences Applications
Authors: Boghossian Ardemis A. , Zhang Jingqing , Barone Paul W. , Reuel Nigel F. , Kim Jong‐Ho , Heller Daniel A. , Ahn Jin‐Ho , Hilmer Andrew J. , Rwei Alina , Arkalgud Jyoti R. , Zhang Cathy T. , Strano Michael S. 
Published: July 2011

AbstractMany properties of single‐walled carbon nanotubes (SWCNTs) make them ideal candidates for sensors, particularly for biological systems. Both their fluorescence in the near‐infrared range of 820–1600 nm, where absorption by biological tissues is often minimal, and their inherent photostability are desirable attributes for the design of in vitro and in vivo sensors. The mechanisms by which a target molecule can selectively alter the fluorescent emission include primarily changes in emission wavelength (i.e., solvatochromism) and intensity, including effects such as charge‐transfer transition bleaching and exciton quenching. The central challenge lies in engineering the nanotube interface to be selective for the analyte of interest. In this work, we review the recent development in this area over the past few years, and describe the design rules that we have developed for detecting various analytes, ranging from stable small molecules and reactive oxygen species (ROS) or reactive nitrogen species (RNS) to macromolecules. Applications to in vivo sensor measurements using these sensors are also described. In addition, the emerging field of SWCNT‐based single‐molecule detection using band gap fluorescence and the recent efforts to accurately quantify and utilize this unique class of stochastic sensors are also described in this article.
Visible‐Light Harvesting with Cyclometalated Iridium(III) Complexes Having Long‐Lived 3IL Excited States and Their Application in Triplet–Triplet‐Annihilation Based Upconversion (Eur. J. Inorg. Chem. 21/2011)
Authors: Sun Jifu , Wu Wanhua , Guo Huimin , Zhao Jianzhang 
Published: July 2011

AbstractThe cover picture shows the triplet‐triplet‐annihilation (TTA) upconversion between a visible‐light harvesting IrIII complex and 9,10‐diphenylanthracene (DPA). In the upper left‐hand corner is the qualitative Jablonski diagram describing the photophysical process involved in the TTA upconversion. Although the coumarin‐containing IrIII complexes are weakly phosphorescent, we proved that the long‐lived 3IL excited state was populated upon photoexcitation by using time‐resolved transient absorption spectroscopy, emission spectroscopy at 77 K, and DFT calculations. The complexes were used as triplet sensitizers for TTA upconversion, and an upconversion quantum yield of up to 23.4 ° was observed. Thus, we propose that the T1 excited state of the triplet sensitizers does not necessarily have to be emissive. Details are discussed in the article by J. Zhao et al. on p. 3165 ff. The cover art was produced by Dr. Xin Liu (Dalian University of Technology).
The Asymmetric Friedel–Crafts Reaction of Indoles with Fluoroalkylated Nitroalkenes Catalyzed by Chiral Phosphoric Acid
Authors: Lin Jin‐Hong , Xiao Ji‐Chang 
Published: July 2011

AbstractThe enantioselective Friedel–Crafts fluoroalkylation of indoles with fluoroalkylated nitroalkenes, catalyzed by chiral phosphoric acid is described. The regioselectivity of fluoroalkylated nitroalkenes is a problem worth discussing, and it was found that the carbon atom adjacent to the fluoroalkyl group is more reactive than that adjacent to NO2 group.
Prevalence and clinical correlates of restless legs syndrome among psychogeriatric patients
Authors: Agüera‐Ortiz Luis , Perez M. Isabel Ramos‐García , Osorio Ricardo S. , Sacks Hayley , Palomo Tomás 
Published: July 2011

AbstractObjectiveTo evaluate the prevalence, clinical features, and comorbidities of restless legs syndrome (RLS) among psychogeriatric patients in an out‐patient clinical setting.MethodsCross‐sectional study of a sample of 100 non‐demented psychogeriatric outpatients that were assessed for the presence of RLS using the Revised International Restless Legs Syndrome Study Group criteria and other support criteria. Medical and psychiatric illnesses, drug treatments, and other risk factors for RLS were documented.ResultsPrevalence of definite RLS in our sample was 11.11% with an additional prevalence of 10.10% of possible RLS. None of these patients had received a diagnosis of RLS previously. RLS was associated with major depressive disorder and with hypertension, but not with other previously described risk factors as female gender, some medical conditions, or psychoactive drug treatments.ConclusionsRLS is a frequent condition in psychogeriatric patients, especially among those with depression, and is commonly underdiagnosed and undertreated. Clinicians should routinely ask for RLS symptoms when assessing their patients in their regular clinical practice. Copyright © 2011 John Wiley & Sons, Ltd.
X‐ray structural analysis and theoretical studies of new phosphite‐derived ylides
Authors: Rostamizadeh Mohsen , Maghsoodlou Malek Taher , Habibi‐Khorassani Sayyed Mostafa , Hazeri Nourallah , Charati Faramarz Rostami , Kazemian Mohammad Amin , Skelton Brian W. , Makha Mohamed 
Published: July 2011

AbstractThe reaction between dialkyl acetylenedicarboxylates and NH heterocyclic compounds in the presence of triethyl phosphite leads to stable phosphorus ylide derivatives in good yields. The X‐ray crystallographic data and theoretical study show that there is a resonance between two bonds of C19P1 and C191O191 in phosphorus ylide 4d. This compound crystallizes in the orthorhombic system, space group (Pca21), with unit cell parameters a = 17.3699(3) Å, b = 13.5500(2) Å, c = 18.4627(3) Å, α = 90°, β = 90°, γ = 90°, Z = 8, and V = 4345.4(12) Å3. © 2011 Wiley Periodicals, Inc. Heteroatom Chem 22:715–722, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/hc.20739
Neuroimmunomodulative properties of dipeptidyl peptidase IV/CD26 in a TNBS‐induced model of colitis in mice
Authors: Baticic Lara , Detel Dijana , Kucic Natalia , Buljevic Suncica , Pugel Ester Pernjak , Varljen Jadranka 
Published: July 2011

AbstractCausal connections between dipeptidyl peptidase IV, also known as CD26 molecule (DPP IV/CD26) and inflammatory bowel disease (IBD) have been shown, but mechanisms of these interactions are unclear. Our hypothesis was that DPP IV/CD26 could affect the neuroimmune response during inflammatory events. Therefore, we aimed to evaluate its possible role and the relevance of the gut–brain axis in a model of IBD in mice. Trinitrobenzenesulfonic acid‐induced (TNBS) colitis was induced in CD26‐deficient (CD26−/−) and wild‐type (C57BL/6) mice. Pathohistological and histomorphometrical measurements were done. Concentrations and protein expressions of DPP IV/CD26 substrates neuropeptide Y (NPY) and vasoactive intestinal peptide (VIP) were determined. Concentrations of IL‐6 and IL‐10 were evaluated. Investigations were conducted at systemic and local levels. Acute inflammation induced increased serum NPY concentrations in both mice strains, more enhanced in CD26−/− mice. Increased NPY concentrations were found in colon and brain of C57BL/6 mice, while in CD26−/− animals only in colon. VIP and IL‐6 serum and tissue concentrations were increased in both mice strains in acute inflammation, more pronouncedly in CD26−/− mice. IL‐10 concentrations, after a decrease in serum of both mice strains, increased promptly in CD26−/− mice. Decreased IL‐10 concentration was found in brain of C57BL/6 mice, while it was increased in colon of CD26−/− mice in acute inflammation. DPP IV/CD26 deficiency affects the neuroimmune response at systemic and local levels during colitis development and resolution in mice. Inflammatory changes in the colon reflected on investigated parameters in the brain, suggesting an important role of the gut–brain axis in IBD pathogenesis. J. Cell. Biochem. 112: 3322–3333, 2011. © 2011 Wiley Periodicals, Inc.
Involvement of ubiquitin–proteasome system in icariin‐induced cardiomyocyte differentiation of embryonic stem cells using two‐dimensional gel electrophoresis
Authors: Zhu Dan‐yan , Cui Rong , Zhang Ying‐ying , Li Huan , Zhou Li‐min , Lou Yi‐jia 
Published: July 2011

AbstractIcariin has been shown to significantly facilitate the differentiation of embryonic stem (ES) cells into cardiomyocytes in vitro. However, the mechanism underlying the icariin‐induced cardiomyocyte differentiation is still not fully understood. In the present study, 52 differentially displayed proteins selected from two‐dimensional electrophoresis gels were identified by MALDI‐TOF mass spectrometry analysis. More than half of proteins could be assigned to six main categories: (1) protein synthesis, metabolism, processing and degradation, (2) stress response, (3) cytoskeleton proteins, (4) energy metabolism, (5) carbohydrate metabolism/transport, and (6) RNA/other nucleic acids metabolisms and transport, nuclear proteins. MALDI‐TOF/MS showed that icariin treatment resulted in the induction of five ubiquitin–proteasome system (UPS)‐related proteins, such as ubiquitin carboxy‐terminal hydrolase L1 (UCH‐L1), ubiquitin‐conjugating enzyme E2N, proteasome 26S, proteasome subunit‐alpha type 6, and proteasome subunit‐alpha type 2 in the differentiated cardiomyocytes. These results implied that UPS might play an important role in the control of cardiomyocyte differentiation. Epoxomicin (a proteasome inhibitor) significantly reduced the cardiomyocyte differentiation rate of ES cells and proteasome activities, as well as inhibited NF‐κB translocation into the nucleus, which were evidently reversed by presence of icariin. Meanwhile, icariin could significantly reverse the reduction of four proteins (proteasome subunit‐alpha type 6, proteasome subunit‐alpha type 2, UCH‐L1, and ubiquitin‐conjugating enzyme E2N) expressions owing to application of epoxomicin. These suggest UPS could be a means by which icariin may regulate expressions of key proteins that control cardiomyocyte differentiation. Taken together, these results indicated that UPS played an important role in ES cell differentiate into cardiomyocytes induced by icariin. J. Cell. Biochem. 112: 3343–3353, 2011. © 2011 Wiley Periodicals, Inc.
Glucocorticoid receptor‐mediated transcriptional activation of S100P gene coding for cancer‐related calcium‐binding protein
Authors: Tothova Veronika , Isola Jorma , Parkkila Seppo , Kopacek Juraj , Pastorek Jaromir , Pastorekova Silvia , Gibadulinova Adriana 
Published: July 2011

AbstractS100P is a member of the S100 family of calcium‐binding proteins involved in calcium sensing and signal transduction. Its abnormal expression and biological activities are linked to tumor phenotype, namely to increased survival, proliferation, invasion and metastatic propensity of tumor cells. Association of S100P with outcome of tumor treatment and preliminary data from S100P promoter analysis prompted us to study regulation of S100P expression by glucocorticoids, which are implicated in tumor response to chemotherapy. We showed that dexamethasone (DX), a representative glucocorticoid, was capable to induce activity of S100P promoter by means of increased expression, nuclear translocation, and transactivation properties of the glucocorticoid receptor (GR). Moreover, DX treatment led to decreased phosphorylation of ERK1/2, reduced transcriptional activity of AP1, and modulated activity of some additional transcription factors. We identified a promoter region responsible for DX‐mediated transactivation and proved GR binding to S100P promoter. We found that the effect of DX was enhanced by partial but not complete inhibition of the MAPK/ERK pathway, supporting an active crosstalk between GR and MAPK/ERK signal transduction in control of S100P expression. On the other hand, suppression of GR mRNA level by transient siRNA expression resulted in reduced S100P transcription. The role of GR activation in S100P regulation was supported by co‐expression of GR with S100P in cells treated with DX. These data suggest that S100P is a direct transcriptional target of glucocorticoid‐mediated signaling in tumor cells that is activated through the interplay of GR and MAPK pathways. J. Cell. Biochem. 112: 3373–3384, 2011. © 2011 Wiley Periodicals, Inc.
Interleukin‐4 inhibits RANKL‐induced NFATc1 expression via STAT6: A novel mechanism mediating its blockade of osteoclastogenesis
Authors: Cheng Jing , Liu Jianzhong , Shi Zhenqi , Xu Duorong , Luo Shaokai , Siegal Gene P. , Feng Xu , Wei Shi 
Published: July 2011

AbstractInterleukin‐4 (IL‐4) is an important immune regulatory protein that possesses potent anti‐osteoclastogenic properties, and does so via the transcription factor STAT6. Previous studies have shown that IL‐4 selectively blocks RANKL‐induced activation of NF‐κB and mitogen‐activated protein kinase (MAPK) pathway molecules, suggesting that the cytokine arrests osteoclastogenesis by blockade of these signaling cascades. However, the fact that the inhibitory effect on these pathways requires prolonged IL‐4 pretreatment, and that the cytokine fails to exert an anti‐osteoclastogenic effect after short‐term pre‐exposure of RANKL to osteoclast precursors, suggests that an additional, more immediate mechanism may also be involved. In this study, we found that simultaneous exposure of IL‐4 did not alter RANKL‐dependent activation of NF‐κB or MAPKs, whereas the cytokine did block RANKL‐induced nuclear factor activated T cells c1 (NFATc1), a master osteoclastogenic transcription factor. This inhibitory effect of IL‐4 required STAT6, consistent with its functional role in osteoclastogenesis. In addition, the cytokine also partially impaired RANKL‐stimulated bone resorption. Furthermore, IL‐4 suppressed expression of RANKL‐induced osteoclast specific genes in a STAT6‐dependent manner, but failed to do so when osteoclast precursors were pre‐exposed to RANKL. Thus, we provide the first evidence that IL‐4 inhibits osteoclast formation by inhibiting RANKL induction of NFATc1 via STAT6 as an early event, in addition to its suppression of other signaling pathways. The inhibitory effect is ultimately regulated at the gene expression transcriptional level. J. Cell. Biochem. 112: 3385–3392, 2011. © 2011 Wiley Periodicals, Inc.
Plasma glutamine decreases immediately after surgery and is related to incisiveness
Authors: Viggiano Emanuela , Passavanti Maria Beatrice , Pace Maria Caterina , Sansone Pasquale , Spaziano Giuseppe , Viggiano Alessandro , Aurilio Caterina , Monda Marcellino , Viggiano Andrea , Pota Vincenzo , De Luca Bruno , De Luca Elena 
Published: July 2011

AbstractGlutamine (gln) is the most abundant free amino acid in the blood. It is involved in important metabolic and biochemical processes, like cell proliferation and oxidative stress. Previous studies have demonstrated that gln concentration in human plasma decreases in several conditions such as sepsis, ischemia‐reperfusion, trauma, major surgery and burn. The aim of the present work was to compare the acute effects of different types of surgical interventions and of anesthetization on blood gln concentration. Plasma samples from 88 subjects (30 males and 58 females) were collected before and after major or minor surgery and the gln concentration was analyzed with high‐performance liquid chromatography. The results showed that plasma gln concentration after surgery was lower than pre‐surgery values and that in major surgery the decrease of gln was higher than in minor surgery. No significant effect was shown for sex or type of anesthesia. These results demonstrate the importance of a gln supplementation before a surgical intervention and show that the amount of gln supplementation should also be adjusted based on the type of surgery. J. Cell. Physiol. 227: 1988–1991, 2012. © 2011 Wiley Periodicals, Inc.
A multipotent clonal human periodontal ligament cell line with neural crest cell phenotypes promotes neurocytic differentiation, migration, and survival
Authors: Tomokiyo Atsushi , Maeda Hidefumi , Fujii Shinsuke , Monnouchi Satoshi , Wada Naohisa , Kono Kiyomi , Yamamoto Naohide , Koori Katsuaki , Teramatsu Yoko , Akamine Akifumi 
Published: July 2011

AbstractRepair of injured peripheral nerve is thought to play important roles in tissue homeostasis and regeneration. Recent experiments have demonstrated enhanced functional recovery of damaged neurons by some types of somatic stem cells. It remains unclear, however, if periodontal ligament (PDL) stem cells possess such functions. We recently developed a multipotent clonal human PDL cell line, termed cell line 1‐17. Here, we investigated the effects of this cell line on neurocytic differentiation, migration, and survival. This cell line expressed the neural crest cell marker genes Slug, SOX10, Nestin, p75NTR, and CD49d and mesenchymal stem cell‐related markers CD13, CD29, CD44, CD71, CD90, CD105, and CD166. Rat adrenal pheochromocytoma cells (PC12 cells) underwent neurocytic differentiation when co‐cultured with cell line 1‐17 or in conditioned medium from cell line 1‐17 (1‐17CM). ELISA analysis revealed that 1‐17CM contained approximately 50 pg/ml nerve growth factor (NGF). Cell line 1‐17‐induced migration of PC12 cells, which was inhibited by a neutralizing antibody against NGF. Furthermore, 1‐17CM exerted antiapoptotic effects on differentiated PC12 cells as evidenced by inhibition of neurite retraction, reduction in annexin V and caspase‐3/7 staining, and induction of Bcl‐2 and Bcl‐xL mRNA expression. Thus, cell line 1‐17 promoted neurocytic differentiation, migration, and survival through secretion of NGF and possibly synergistic factors. PDL stem cells may play a role in peripheral nerve reinnervation during PDL regeneration. J. Cell. Physiol. 227: 2040–2050, 2012. © 2011 Wiley Periodicals, Inc.
Decreased brain stiffness in Alzheimer's disease determined by magnetic resonance elastography
Authors: Murphy Matthew C. , Huston John , Jack Clifford R. , Glaser Kevin J. , Manduca Armando , Felmlee Joel P. , Ehman Richard L. 
Published: July 2011

AbstractPurpose:To test patient acceptance and reproducibility of the 3D magnetic resonance elastography (MRE) brain exam using a soft vibration source, and to determine if MRE could noninvasively measure a change in the elastic properties of the brain parenchyma due to Alzheimer's disease (AD).Materials and Methods:MRE exams were performed using an accelerated spin‐echo echo planar imaging (EPI) pulse sequence and stiffness was calculated with a 3D direct inversion algorithm. Reproducibility of the technique was assessed in 10 male volunteers, who each underwent four MRE exams separated into two imaging sessions. The effect of AD on brain stiffness was assessed in 28 volunteers, 7 with probable AD, 14 age‐ and gender‐matched PIB‐negative (Pittsburgh Compound B, a PET amyloid imaging ligand) cognitively normal controls (CN−), and 7 age‐ and gender‐matched PIB‐positive cognitively normal controls (CN+).Results:The median stiffness of the 10 volunteers was 3.07 kPa with a range of 0.40 kPa. The median and maximum coefficients of variation for these volunteers were 1.71% and 3.07%. The median stiffness of the 14 CN− subjects was 2.37 kPa (0.44 kPa range) compared to 2.32 kPa (0.49 kPa range) within the CN+ group and 2.20 kPa (0.33 kPa range) within the AD group. A significant difference was found between the three groups (P = 0.0055, Kruskal–Wallis one‐way analysis of variance). Both the CN+ and CN− groups were significantly different from the AD group.Conclusion:3D MRE of the brain can be performed reproducibly and demonstrates significantly reduced brain tissue stiffness in patients with AD. J. Magn. Reson. Imaging 2011;. © 2011 Wiley‐Liss, Inc.