bluuebunny/crossref_metadata_2025_split huggingface dataset:
Understory bamboo removal impacts on woody seedling regeneration in forest ecosystems: a meta-analysis
Authors: Luo Weixue , Ma Yuxuan , Luo Jie , Han Shunxin , Sun Chengxiang , You Ziyi , Du Haohan , Li Zongfeng , Liu Jinchun , Tao Jianping 
Published: June 2024

Abstract
Background
Tree seedling regeneration in forests is often hindered by the competitive influence of dense understory bamboo competition. While localized studies have investigated the ecological effects of understory bamboo removal on tree seedlings, a comprehensive analysis at a global scale is lacking. In this meta-analysis, we synthesized 497 observations from 32 experimental studies to assess the overall effects of understory bamboo removal on tree seedling regeneration.

Results
The results showed that understory bamboo removal enhanced tree seedling survival, emergence, and height growth. However, the response of tree seedlings to bamboo removal varied depending on regeneration characteristics, forest types, and bamboo removal methods. Specifically, understory bamboo removal increased the survival rate of deciduous seedlings but had no significant effect on evergreen seedlings. For regeneration stages, bamboo removal had a significant positive effect on the survival rate of saplings but not on seedlings. Regarding differences across forest types, bamboo removal significantly increased the emergence density of seedlings in deciduous broadleaf forests but had a significant negative influence in evergreen and mixed evergreen-deciduous forests. Additionally, natural removal of bamboo showed a greater positive effect on seedlings than bamboo removal by artificial or animal gnawing methods. Furthermore, we found that the duration of bamboo removal, mean annual temperature, precipitation of seasonality, and soil pH strongly influenced the response ratios of tree seedling regeneration.

Conclusions
Our meta-analysis demonstrates the significant effects of understory bamboo removal on multiple facets of tree seedling dynamics across different regeneration characteristics, forest types, and bamboo removal methods. In addition, our study emphasizes that the duration of bamboo removal, climate, and soil pH have a critical effect on tree seedling regeneration. Our findings elucidate the effects of understory bamboo removal on seedling regeneration, offering robust scientific insights for sustainable forest management.
Using 42 CFR part 2 revisions to integrate substance use disorder treatment information into electronic health records at a safety net health system
Authors: Tillman Alexandra R. , Bacon Emily , Bender Brooke , McEwen Dean , Blum Joshua , Hoag Matthew , Scott Kenneth A. , Everhart Rachel , Hanratty Rebecca , Podewils Laura J. , Close Carolina , Mills John , Davidson Arthur J. 
Published: June 2024

Abstract
Background
Regulations put in place to protect the privacy of individuals receiving substance use disorder (SUD) treatment have resulted in an unintended consequence of siloed SUD treatment and referral information outside of the integrated electronic health record (EHR). Recent revisions to these regulations have opened the door to data integration, which creates opportunities for enhanced patient care and more efficient workflows. We report on the experience of one safety-net hospital system integrating SUD treatment data into the EHR.

Methods
SUD treatment and referral information was integrated from siloed systems into the EHR through the implementation of a referral order, treatment episode definition, and referral and episode-related tools for addiction therapists and other clinicians. Integration was evaluated by monitoring SUD treatment episode characteristics, patient characteristics, referral linkage, and treatment episode retention before and after integration. Satisfaction of end-users with the new tools was evaluated through a survey of addiction therapists.

Results
After integration, three more SUD treatment programs were represented in the EHR. This increased the number of patients that could be tracked as initiating SUD treatment by 250%, from 562 before to 1,411 after integration. After integration, overall referral linkage declined (74% vs. 48%) and treatment episode retention at 90-days was higher (45% vs. 74%). Addiction therapists appreciated the efficiency of having all SUD treatment information in the EHR but did not find that the tools provided a large time savings shortly after integration.

Conclusions
Integration of SUD treatment program data into the EHR facilitated both care coordination in patient treatment and quality improvement initiatives for treatment programs. Referral linkage and retention rates were likely modified by a broader capture of patients and changed outcome definition criteria. Greater preparatory workflow analysis may decrease initial end-user burden. Integration of siloed data, made possible given revised regulations, is essential to an efficient hub-and-spoke model of care, which must standardize and coordinate patient care across multiple clinics and departments.
Opioid-sparing effects of ultrasound-guided erector spinae plane block for video-assisted thoracoscopic surgery: a randomized controlled study
Authors: Xu Huan , Wu Wei , Chen Xue , He Wenxin , Shi Hong 
Published: June 2024

Abstract
Background
The erector spinae plane block (ESPB) is a new analgesic method used in thoracic surgery. However, few studies have characterized their effects on perioperative opioid consumption. We aimed to evaluate the effects of ESPB on perioperative opioid consumption in patients who underwent video-assisted thoracoscopic surgery (VATS).

Methods
This was a randomized, observer-blinded clinical trial at a single-centre academic hospital. Eighty patients were scheduled for thoracoscopic segmentectomy or lobectomy by VATS for lung cancer. Forty participants were randomly assigned to ESPB or control group. All patients received intravenous patient-controlled postoperative analgesia. Perioperative opioid consumption, visual analogue scale (VAS) scores, and adverse events were recorded.

Results
Intraoperative and postoperative opioid consumption and static/dynamic VAS scores were significantly lower in the early hours after VATS in the ESPB group (p < 0.05) than the control group. No significant differences were observed in adverse effects between the two groups.

Conclusions
ESPB reduced intraoperative opioid consumption and early postoperative pain in patients undergoing VATS. Our findings support the view that ESPB is a safe and highly effective option for regional analgesia for VATS.

Trial registration
http://www.chictr.org.cn, ChiCTR1800019335.
C-reactive protein is a predictor for lower-extremity deep venous thrombosis in patients with primary intracerebral hemorrhage
Authors: Wang Gang , Wu Bao-Fang , Zhao Wen-Jun , Hu Wei-Peng , Wang Jia-Yin , Gao Hong-Zhi 
Published: June 2024

Abstract
Objective
Our study aimed to determine whether there exists an association between low-grade systemic inflammation, as measured by serum C-reactive protein (CRP), and the risk of lower-extremity deep venous thrombosis (LEDVT) in patients with primary intracerebral hemorrhage (ICH).

Methods
This observational study was retrospectively conducted on patients with primary ICH who were presented to two tertiary medical centers between January 2021 and August 2022. The primary outcome was detecting LEDVT occurrence within 14 days from the onset of the acute ICH episode. Weighted logistic regression and restricted cubic spline models were employed to estimate the association between CRP and LEDVT following 1:1 propensity score matching (PSM).

Results
Of the 538 patients with primary ICH who met the inclusion criteria, 76 (14.13%) experienced LEDVT. Based on the cut-off levels of CRP measured upon admission from the receiver operating characteristic (ROC) curve, patients with primary ICH were categorized into two groups: (i) CRP < 1.59 mg/L and (ii) CRP ≥ 1.59 mg/L. After 1:1 PSM, the LEDVT events occurred in 24.6% of patients with CRP ≥ 1.59 mg/L and 4.1% of patients with CRP < 1.59 mg/L (P < 0.001). ROC curve revealed the area under the ROC curve of 0.717 [95% confidence interval (CI) 0.669–0.761, P < 0.001] for CRP to predict LEDVT with a sensitivity of 85.71% and specificity of 56.29%. After adjusting for all confounding variables, the occurrence of LEDVT in ICH patients with higher CRP levels (≥ 1.59 mg/L) was 10.8 times higher compared to those with lower CRP levels (95% CI 4.5–25.8, P < 0.001). A nonlinear association was observed between CRP and an increased risk of LEDVT in the fully adjusted model (P for overall < 0.001, P for nonlinear = 0.001). The subgroup results indicated a consistent positive link between CRP and LEDVT events following primary ICH.

Conclusions
Higher initial CRP levels (CRP as a dichotomized variable) in patients with primary ICH are significantly associated with an increased risk of LEDVT and may help identify high-risk patients with LEDVT. Clinicians should be vigilant to enable early and effective intervention in patients at high risk of LEDVT.
Effect of atractylenolide III on zearalenone-induced Snail1-mediated epithelial–mesenchymal transition in porcine intestinal epithelium
Authors: Kim Na Yeon , Kim Myoung Ok , Shin Sangsu , Kwon Woo-Sung , Kim Bomi , Lee Joon Yeop , In Lee Sang 
Published: June 2024

Abstract
Background
The intestinal epithelium performs essential physiological functions, such as nutrient absorption, and acts as a barrier to prevent the entry of harmful substances. Mycotoxins are prevalent contaminants found in animal feed that exert harmful effects on the health of livestock. Zearalenone (ZEA) is produced by the Fusarium genus and induces gastrointestinal dysfunction and disrupts the health and immune system of animals. Here, we evaluated the molecular mechanisms that regulate the effects of ZEA on the porcine intestinal epithelium.

Results
Treatment of IPEC-J2 cells with ZEA decreased the expression of E-cadherin and increased the expression of Snai1 and Vimentin, which induced Snail1-mediated epithelial-to-mesenchymal transition (EMT). In addition, ZEA induces Snail-mediated EMT through the activation of TGF-β signaling. The treatment of IPEC-J2 cells with atractylenolide III, which were exposed to ZEA, alleviated EMT.

Conclusions
Our findings provide insights into the molecular mechanisms of ZEA toxicity in porcine intestinal epithelial cells and ways to mitigate it.
The relationship between self-regulation, cognitive flexibility, and resilience among students: a structural equation modeling
Authors: Nakhostin-Khayyat Mohammad , Borjali Mahmoud , Zeinali Maryam , Fardi Deniz , Montazeri Ali 
Published: June 2024

Abstract
Background
Cognitive flexibility is an important construct that contributes to one’s own thoughts, behaviors, and feelings to achieve his or her goals. Thus, it could play an essential role in students’ educational achievements. This study aimed to investigate the mediating role of cognitive flexibility in the relationship between self-regulation and resilience among students.

Method
This was a cross-sectional study conducted on a sample of students during the 2022 and 2023 academic years. Students were selected from Tehran and Karaj universities (two metropolitans in central Iran). Data collection instruments included the Bouffard’s Self-Regulation Scale, the Cognitive Flexibility Inventory (CFI), and the Connor-Davidson Resilience Scale (CD-RSC). Subsequently, the data were analyzed using structural equation modeling via SPSS and AMOS software to examine the relationships among variables.

Results
In all 302 students participated in the study. The mean age of students was 25.8 (SD = 4.05) years. The findings indicated that self-regulation had a marked positive direct effect on cognitive flexibility (β = 0.23, p < 0.001), and resilience (β = 0.88, t = 19.50, p < 0.001). Similarly, cognitive flexibility displayed a strong positive influence on resilience (β = 0.1, p < 0.001) it showed an indirect mediating role between self-regulation and resilience (0.02), while resilience demonstrated a negative indirect effect on self-regulation and cognitive flexibility (-0.23). The goodness of fit indices validated the proposed model. Furthermore, the analysis revealed the significance of the final model’s direct path coefficients, underscoring the mediating role of cognitive flexibility between self-regulation and resilience among students.

Conclusion
The findings indicated a pivotal interrelationship among self-regulation, cognitive flexibility, and resilience in students. The significant positive relationship among these constructs underscores the importance of fostering cognitive flexibility practices and self-regulation in educational settings.
A case of successful contribution of therapeutic drug monitoring of valganciclovir as the prophylaxis against cytomegalovirus infection in a lung transplant recipient
Authors: Katada Yoshiki , Umemura Keisuke , Nakagawa Shunsaku , Katsube Yurie , Tsuda Masahiro , Tanaka Satona , Date Hiroshi , Nagao Miki , Terada Tomohiro 
Published: June 2024

Abstract
Background
Ganciclovir and its prodrug, valganciclovir, are first-line agents for cytomegalovirus infection prophylaxis after lung transplantation. Although valganciclovir prophylaxis is known to result in severe leukopenia as an adverse effect, dosage adjustment based on therapeutic drug monitoring (TDM) of ganciclovir concentration is not generally implemented in clinical practice.

Case presentation
In this report, we describe the case of a female in her fifties after lung transplantation who successfully maintained valganciclovir prophylaxis under TDM with a minimal occurrence of severe leukopenia. Valganciclovir administration was initiated at a conventional dose of 450 mg/day on postoperative day 43 but was reduced to 450 mg/2 days on postoperative day 69 because of a decrease in white blood cell count and an increase in trough ganciclovir concentration. Subsequently, the valganciclovir dose adjustment was switched from label-indicated renal function-guided dosing to TDM-based dosing, targeting a trough level of 300–800 ng/mL. This target range was determined through deliberations with infectious disease specialists and pharmacists based on previously reported data. The TDM-based dose adjustment successfully prevented cytomegalovirus reactivation without causing significant adverse effects. Valganciclovir prophylaxis was completed on postoperative day 256, and the patient was transferred to another hospital for rehabilitation.

Conclusions
The findings of the present case suggest that TDM-based dosing could be helpful for clinicians in optimizing the prophylactic administration of valganciclovir in patients undergoing lung transplantation.
The Effect of Palmitoylethanolamide (PEA) on Skeletal Muscle Hypertrophy, Strength, and Power in Response to Resistance Training in Healthy Active Adults: A Double-Blind Randomized Control Trial
Authors: Huschtscha Zoya , Silver Jessica , Gerhardy Michael , Urwin Charles S. , Kenney Nathan , Le Viet Hung , Fyfe Jackson J. , Feros Simon A. , Betik Andrew C. , Shaw Christopher S. , Main Luana C. , Abbott Gavin , Tan Sze-Yen , May Anthony , Smith Craig M. , Kuriel Vicky , Barnard Jackson , Hamilton D. Lee 
Published: June 2024

Abstract
Background
Palmitoylethanolamide (PEA) has analgesic/anti-inflammatory properties that may be a suitable alternative to over-the-counter (OTC) non-steroidal analgesics/anti-inflammatories. While OTC pain medications can impair strength training adaptations, the mechanism of action of PEA is distinct from these and it may not negatively affect skeletal muscle adaptations to strength training.

Methods
The primary aim of this study was to investigate the effects of daily PEA supplementation (350 mg Levagen + equivalent to 300 mg PEA) combined with 8-weeks of resistance training on lean body mass with secondary aims addressing strength, power, sleep, and wellbeing compared to placebo (PLA) in young, healthy, active adults. In a randomized, controlled, double-blinded trial, 52 untrained, recreationally active participants aged 18–35 y were allocated to either the PEA or PLA groups. Participants consumed either 2 × 175 mg Levagen + PEA or identically matched maltodextrin capsules during an 8-week period of whole-body resistance training. This trial assessed the pre- to post- changes in total and regional lean body mass, muscular strength (1-RM bench, isometric mid-thigh pull), muscular power [countermovement jump (CMJ), bench throw], pain associated with exercise training, sleep, and wellbeing compared with the PEA or PLA condition.

Results
48 Participants were included in the final intention to treat (ITT) analysis and we also conducted per protocol (PP) analysis (n = 42). There were no significant between-group differences for total or regional lean muscle mass post-intervention. There was a significantly higher jump height (CMJ) at week 10 in the PEA group compared to the PLA (Adjusted mean difference [95% CI] p-value; ITT: − 2.94 cm [− 5.15, − 0.74] p = 0.010; PP: − 2.93 cm [− 5.31, − 0.55] p = 0.017). The PLA group had higher 1-RM bench press post-intervention compared with the PEA group (ITT: 2.24 kg [0.12, 4.37] p = 0.039; PP: 2.73 kg [0.40, 5.06] p = 0.023). No significant treatment effects were noted for any of the other outcomes.

Conclusion
PEA supplementation, when combined with 8 weeks of strength training, did not impair lean mass gains and it resulted in significantly higher dynamic lower-body power when compared with the PLA condition.
Trial Registration: Australian New Zealand Clinical Trials Registry (ANZCTR: ACTRN12621001726842p).
Statin therapy improves outcomes in infective endocarditis: evidence from a meta-analysis
Authors: Yaghoobi Mojtaba Hedayat , Heidari Ehsan , Shafiee Arman , Seighali Niloofar , Maghsoodi Mohammad Reza , Bakhtiyari Mahmood 
Published: June 2024

Abstract
Background
Beyond its ability to decrease cholesterol, statin medication has been proved to have a variety of pleiotropic effects, such as anti-inflammatory and immunomodulatory effects. Statins are an appealing therapeutic option for individuals with infective endocarditis because of these effects, as the condition is linked to a strong inflammatory response.

Methods
A comprehensive search was done in Medline/PubMed, Cochrane database (CENTRAL), and Google Scholar to identify relevant studies reporting outcomes of interest (rate of mortality, intensive care unit admission, and embolic events) comparing those who are on statin therapy to nonusers were included. We performed a random effect meta-analysis to pool each study's individual results.

Results
Three articles were included in the study. The pooled results regarding our primary endpoint showed there was a significant reduction in mortality among statin users in all time points (1-year mortality: OR 0.69, 95% CI 0.61–0.79, I2: 0%; Chi2 = 0.01; p < 0.0001). Meta-analysis for the secondary outcome showed statin users are less frequently admitted to the intensive care unit (OR 0.73, 95% CI 0.59–0.90, I2: 0%; Chi2 = 0.00; p = 0.0004). The rate of mortality was significantly lower for those with a previous history of cerebrovascular disease who were on statin therapy compared to those without cerebrovascular diseases (CVD).

Conclusions
The results of the present study support a significant association with statin therapy as a potential treatment proposed for individuals at risk of infective endocarditis.
Endometrial cancer and obesity trends in the United States in the 21st century.
Authors: Francoeur Alex Andrea , Liao Cheng-I , Chang Jenny , Johnson Caitlin Ruth , Clair Kiran , Tewari Krishnansu Sujata , Kapp Daniel Stuart , Chan John K , Bristow Robert E. 
Published: June 2024

5507 Background: Using two comprehensive national databases, we explore trends in obesity and endometrial cancer rates in the United States. Methods: Data on endometrial adenocarcinoma were obtained from the United States Cancer Statistics (USCS) from 2001-2018 and corrected for hysterectomy and pregnancy using Behavioral Risk Factor Surveillance System data. Data on obesity was collected from the National Health and Nutrition Examination Survey (NHANES) database from 1988-2018. Average annual percentage changes (AAPC) were used to describe trends. SEER*Stat 8.3.9.2 and Joinpoint regression program 4.9.0.0 were used for statistical analysis. Results: Using USCS data, 615,656 cases of endometrial adenocarcinoma were identified from 2001-2018. The annual increase in endometrial cancer is as follows: Hispanic 1.37% (p<0.0001), Black 1.30% (p<0.0001), and White: -0.17 (p=0.656). Women aged 20-29 have a 4.48% annual increase (p<0.0001) and women aged 30-39 have a 3.00% annual increase (p<0.0001). On intersection analysis, Hispanic women have the largest rate of increase in the 30-39 age group at 4.67% (p<0.0001), followed by Black women, 3.85% (p<0.0001), and White women 2.12% (p=0.02). In the 20-29 age group, rates of endometrial adenocarcinoma are increasing in White women at 4.79% (p<0.0001) and in Hispanic women 4.29% annually (p<0.0001) (Table). Using the NHANES data, the prevalence of obesity in 2018 in adult women is as follows: Black 56.8%, Hispanic 44.1%, and White 40.9%. Rates of obesity for all women are rising 4.6% yearly since 1988 (p<0.05). Class III obesity rates are rising at 9.19% annually (p<0.05). When looking at trends by age, the 20–29 year old women have the highest annual rise in obesity compared to other age groups (AAPC 7.36%, p<0.05). Rates of Class III obesity are increasing at the highest rate in this group as well (AAPC 14.22%, p<0.05). In the 30–39 year old age group, Class III obesity has been increasing 9.48% annually, p<0.05. Conclusions: The current data demonstrate a temporal association between the increasing incidence of endometrial cancer and obesity, and this effect disproportionately impacts younger women and women of color. While additional research is required to confirm a causal relationship, these data warrant targeted health services and public health interventions to stabilize and ultimately reverse the concomitantly rising rates of obesity and endometrial cancer. [Table: see text]