bluuebunny/crossref_metadata_2025_split huggingface dataset:
A microRNA expression signature predicts meningioma recurrence
Authors: Zhi Feng , Zhou Guangxin , Wang Suinuan , Shi Yimin , Peng Ya , Shao Naiyuan , Guan Wei , Qu Hongtao , Zhang Yi , Wang Qiang , Yang Changchun , Wang Rong , Wu Sujia , Xia Xiwei , Yang Yilin 
Published: June 2012

AbstractThe aberrant expression of microRNAs (miRNAs) is associated with a variety of diseases, including cancer. In our study, we examined the miRNA expression profile of meningiomas, which is a common type of benign intracranial tumor derived from the protective meninges membranes that surround the brain and spinal cord. To define a typical human meningioma miRNA profile, the expression of 200 miRNAs in a training sample set were screened using quantitative reverse transcription polymerase chain reaction analysis, and then significantly altered miRNAs were validated in a secondary independent sample set. Kaplan–Meier and univariate/multivariate Cox proportional hazard regression analyses were performed to assess whether miRNA expression could predict the recurrence of meningioma after tumor resection. After a two‐phase selection and validation process, 14 miRNAs were found to exhibit significantly different expression profiles in meningioma samples compared to normal adjacent tissue (NAT) samples. Unsupervised clustering analysis indicated that the 14‐miRNA profile differed between tumor and NAT samples. Downregulation of miR‐29c‐3p and miR‐219‐5p were found to be associated with advanced clinical stages of meningioma. Kaplan–Meier analysis showed that high expression of miR‐190a and low expression of miR‐29c‐3p and miR‐219‐5p correlated significantly with higher recurrence rates in meningioma patients. Cox proportional hazard regression analysis revealed that miR‐190a expression level is an important prognostic predictor that is independent of other clinicopathological factors. Our results suggest that the use of miRNA profiling has significant potential as an effective diagnostic and prognostic marker in defining the expression signature of meningiomas and in predicting postsurgical outcomes.
Thyroid cancer risk and dietary nitrate and nitrite intake in the Shanghai women's health study
Authors: Aschebrook‐Kilfoy Briseis , Shu Xiao‐Ou , Gao Yu‐Tang , Ji Bu‐Tian , Yang Gong , Li Hong Lan , Rothman Nathaniel , Chow Wong‐Ho , Zheng Wei , Ward Mary H. 
Published: June 2012

AbstractNitrate and nitrite are precursors in the endogenous formation of N‐nitroso compounds and nitrate can disrupt thyroid homeostasis by inhibiting iodide uptake. We evaluated nitrate and nitrite intake and risk of thyroid cancer in the Shanghai Women's Health Study that included 73,317 women, aged 40–70 years enrolled in 1996–2000. Dietary intake was assessed at baseline using a food frequency questionnaire. During approximately 11 years of follow‐up, 164 incident thyroid cancer cases with complete dietary information were identified. We used Cox proportional hazards regression to estimate relative risks (RRs). We determined the nitrate and nitrite contents of foods using values from the published literature and focusing on regional values for Chinese foods. Nitrate intake was not associated with thyroid cancer risk [RRQ4 = 0.93; 95% confidence interval (CI): 0.42–2.07; p for trend = 0.40]. Compared to the lowest quartile, women with the highest dietary nitrite intake had about a twofold risk of thyroid cancer (RRQ4 = 2.05; 95%CI: 1.20–3.51), but there was not a monotonic trend with increasing intake (p for trend = 0.36). The trend with increasing nitrite intake from animal sources was significant (p for trend = 0.02) and was stronger for nitrite from processed meats (RRQ4 = 1.96; 95%CI: 1.28–2.99; p for trend < 0.01). Although we did not observe an association for nitrate as hypothesized, our results suggest that women consuming higher levels of nitrite from animal sources, particularly from processed meat, may have an increased risk of thyroid cancer.
Identity exploration in the dating domain: The role of attachment dimensions and parenting practices
Authors: Pittman Joe F. , Kerpelman Jennifer L. , Soto Janet B. , Adler‐Baeder Francesca M. 
Published: June 2012

ABSTRACTWe examined relations among perceived parenting practices (support and psychological control), attachment dimensions for romantic relationships (anxiety and avoidance) and exploration of the dating identity among actively dating adolescents in two high school aged samples. In the all female sample of Study 1 (n = 653) and the gender balanced sample of Study 2 (n = 1003), parenting practices contributed to adolescent exploration of the dating identity. Parent psychological control, but not parental support, also contributed to elevated feeling of avoidance and anxiety in romantic relationships. Avoidance, in turn, was related to less exploration of the dating identity while anxiety seemed to increase it. Gender moderated the model, with parenting practices predicting exploration only for girls and with the links for avoidance and anxiety with exploration stronger for boys than girls. Indirect effects for parenting practices through attachment dimensions on exploration of the dating identity were also noted.
Sadness and consumption
Authors: Garg Nitika , Lerner Jennifer S. 
Published: June 2012

AbstractSadness influences consumption, leading individuals to pay more to acquire new goods and to eat more unhealthy food than they would otherwise. These undesirable consumption effects of sadness can occur without awareness, thus representing more than just conscious attempts at “retail therapy.” In an experiment with real food consumption, the present paper examines the hypothesis that sadness' impact on consumption could be attenuated if the choice context counteracted appraisals of helplessness and enhanced a sense of individual control. Results revealed that: (1) sadness elevates self‐reports of helplessness in response to the emotion‐inducing situation, (2) helplessness mediates the sadness–consumption effect, and (3) inducing a sense of control (via choice) attenuates sadness' effect.
Novel synthetic derivatives of the natural product berbamine inhibit Jak2/Stat3 signaling and induce apoptosis of human melanoma cells
Authors: Nam Sangkil , Xie Jun , Perkins Angela , Ma Yuelong , Yang Fan , Wu Jun , Wang Yan , Xu Rong-zhen , Huang Wendong , Horne David A. , Jove Richard 
Published: June 2012

Persistent Jak/Stat3 signal transduction plays a crucial role in tumorigenesis and immune development. Activated Jak/Stat3 signaling has been validated as a promising molecular target for cancer therapeutics discovery and development. Berbamine (BBM), a natural bis‐benzylisoquinoline alkaloid, was identified from the traditional Chinese herbal medicine Berberis amurensis used for treatment of cancer patients. While BBM has been shown to have potent antitumor activities with low toxicity in various cancer types, the molecular mechanism of action of BBM remains largely unknown. Here, we determine the antitumor activities of 13 synthetic berbamine derivatives (BBMDs) against human solid tumor cells. BBMD3, which is the most potent in this series of novel BBMDs, exhibits over 6‐fold increase in biological activity compared to natural BBM. Moreover, BBMD3, directly inhibits Jak2 autophosphorylation kinase activity in vitro with IC500.69μM. Autophosphorylation of Jak2 kinase at Tyr1007/1008 sites also was strongly inhibited in the range of 15μM of BBMD3 in human melanoma cells at 4h after treatment. Following inhibition of autophosphorylation of Jak2, BBMD3 blocked constitutive activation of downstream Stat3 signaling in melanoma cells. BBMD3 also down‐regulated expression of the Stat3 target proteins Mcl‐1and Bcl‐xL, associated with induction of apoptosis. In sum, our findings demonstrate that the novel berbamine derivative BBMD3 is an inhibitor of the Jak2/Stat3 signaling pathway, providing evidence for a molecular mechanism whereby BBMD3 exerts at least in part the apoptosis of human melanoma cells. In addition, BBMD3 represents a promising lead compound for development of new therapeutics for cancer treatment.
Charge transport in molecular electronic junctions: Compression of the molecular tunnel barrier in the strong coupling regime
Authors: Sayed Sayed Y. , Fereiro Jerry A. , Yan Haijun , McCreery Richard L. , Bergren Adam Johan 
Published: June 2012

Molecular junctions are essentially modified electrodes familiar to electrochemists where the electrolyte is replaced by a conducting “contact.” It is generally hypothesized that changing molecular structure will alter system energy levels leading to a change in the transport barrier. Here, we show the conductance of seven different aromatic molecules covalently bonded to carbon implies a modest range (< 0.5 eV) in the observed transport barrier despite widely different free molecule HOMO energies (> 2 eV range). These results are explained by considering the effect of bonding the molecule to the substrate. Upon bonding, electronic inductive effects modulate the energy levels of the system resulting in compression of the tunneling barrier. Modification of the molecule with donating or withdrawing groups modulate the molecular orbital energies and the contact energy level resulting in a leveling effect that compresses the tunneling barrier into a range much smaller than expected. Whereas the value of the tunneling barrier can be varied by using a different class of molecules (alkanes), using only aromatic structures results in a similar equilibrium value for the tunnel barrier for different structures resulting from partial charge transfer between the molecular layer and the substrate. Thus, the system does not obey the Schottky-Mott limit, and the interaction between the molecular layer and the substrate acts to influence the energy level alignment. These results indicate that the entire system must be considered to determine the impact of a variety of electronic factors that act to determine the tunnel barrier.
Effective lower bounds for the norm of the Poincaré Θ-operator
Authors: Sheingorn Mark 
Published: June 2012

Motivated by McMullen’s proof of Kra’s conjecture that the norm of the Poincaré theta operator

Θ

q
,
Γ

{\Theta _{q,\Gamma }}

is less than

1
1

for every

q
q

and

Γ
\Gamma

of finite volume, this paper provides explicit lower bounds for this norm. These bounds are sufficient to show that

‖

Θ

q
,
Γ

‖

→
1

\left \| {{\Theta _{q,\Gamma }}} \right \| \to 1

for fixed

Γ
\Gamma

as

q
→
∞

q \to \infty

. Here the difference from

1
1

is less than

O
(

(
2
π
e
)

q
−
2

q

q
−
2

)

O(\frac {{{{(2\pi e)}^{q - 2}}}}{{{q^{q - 2}}}})

. For

Γ
(
N
)
⊆
Γ
⊆

Γ
0

(
N
)

\Gamma (N) \subseteq \Gamma \subseteq {\Gamma _0}(N)

,

‖

Θ

q
,
Γ

‖

→
1

\left \| {{\Theta _{q,\Gamma }}} \right \| \to 1

for fixed

q
q

as

N
→
∞

N \to \infty

. Here the difference from

1
1

is

O
(

N

35
−
q

)

O({N^{35 - q}})

. We prove these results by estimating

‖

Θ

q
,
Γ

(

f
p

)

‖

A
q

(
Γ
)

‖

f
p

‖

A
q

\frac {{{{\left \| {{\Theta _{q,\Gamma }}({f_p})} \right \|}_{{A_q}(\Gamma )}}}} {{{{\left \| {{f_p}} \right \|}_{{A_q}}}}}

where the

f
p

{f_p}

are cusp forms of weight

p
≤
q
−
2

p \leq q - 2

. (Thus such functions may in general tend to optimize

Θ

q
,
Γ

{\Theta _{q,\Gamma }}

.) In the case of the congruence subgroups they are taken to be products of

Δ
\Delta

and Eisenstein series. Effective formulae are presented for all implied constants.
Quality of life in asymptomatic children and adolescents before and after diagnosis of hypertrophic cardiomyopathy through family screening
Authors: Bratt Ewa‐Lena , Östman‐Smith Ingegerd , Axelsson Åsa , Berntsson Leeni 
Published: June 2012

Aims and objectives.  The aim of this study was to measure quality of life (QoL) in asymptomatic children with hypertrophic cardiomyopathy (HCM) before and after diagnosis.Background.  Hypertrophic cardiomyopathy is a disease with a 50% risk of inheritance. Children at risk for serious complications can be diagnosed early with family screening, but before embarking on a screening programme, it is important to evaluate the psychosocial consequences of such screening.Design.  Prospective case‐control study.Methods.  Quality of life was measured using a questionnaire by Lindström incorporating both objective and subjective aspects of the three spheres: external, interpersonal and personal, before and two years after diagnosis. The study group consisted of 13 children/adolescents (11 boys), median age 11 (5–18) years, with HCM diagnosed at family screening. All filled out a questionnaire before diagnosis and at follow‐up. 41 healthy children/adolescents (22 boys), median age 11 (2–19) years with a first‐degree relative diagnosed with HCM served as controls; 15/41 also completed follow‐up data.Results.  The total QoL score for all spheres was similar in both groups at baseline and follow‐up. In the interpersonal sphere, it was more common that children diagnosed with HCM had no siblings both at baseline (p = 0·002) and follow‐up (p = 0·005). The family situation, social support and life events were unchanged from baseline to follow‐up. Children with HCM had significantly more psychosomatic symptoms compared with controls at baseline (p < 0·05) but not at follow‐up. Self‐esteem, peer acceptance and satisfaction with school were unchanged and similar between groups.Conclusion.  Family screening for HCM does not appear to negatively influence QoL.Relevance to clinical practice.  This study indicates that family screening of asymptomatic children and adolescents had no significant detrimental effects on QoL. This suggests that the benefits of finding symptomatic individuals at risk for serious complications outweigh concerns about screening asymptomatic individuals.
First flatus time and xerostomia associated with gum‐chewing after liver resection
Authors: Jang Shin Yi , Ju Eun Young , Kim Dae‐Eun , Kim Ji Hye , Kim Yoon Hee , Son Mina , Jang Mija , Jeong Jeong Hee , Kim Kyeong Sug 
Published: June 2012

Aims and objectives.  The aim of this study was to compare the return of bowel function and xerostomia in patients who were and were not instructed to chew gum after elective open liver resection.Background.  Patients who undergo liver resection have limited early ambulation, because they require bed rest after surgery to prevent internal bleeding. They normally also require narcotic analgesics or patient‐controlled analgesia for pain control. For these reasons, they often have symptoms of intestinal gas accumulation, abdominal distension and/or abdominal pain.Design.  Prospective case–control study.Methods.  Forty‐two patients with hepatocellular carcinoma who were treated at Samsung Medical Center from September 2010 to February 2011 were included in this study. Patients who were scheduled for elective liver resection for hepatocellular carcinoma and were over 30 years of age were eligible. Patients were assigned to a gum‐chewing group or a non‐gum‐chewing (control) group before surgery.Results.  The mean age of the gum‐chewing group was 54·9 (±9·7) years, and the mean age of the control group was 55·1 (±8·4) years. The mean values of first flatus time and xerostomia were higher in the control group than in the gum‐chewing group. First flatus time and xerostomia grade were significantly decreased in gum‐chewing group compared with the control group after adjustment for hospitalisation days, duration of surgery and amount of analgesics administered.Conclusion.  Patients who were instructed to chew gum after surgery demonstrated faster bowel function recovery and lower xerostomia grade after elective open liver resection than patients who did not chew gum.Relevance to clinical practice.  Gum‐chewing is an inexpensive, helpful adjunct to standard postoperative care after liver resection.
Dietary counselling with or without oral nutritional supplements in the management of malnourished patients: a systematic review and meta‐analysis of randomised controlled trials
Authors: Baldwin C. , Weekes C. E. 
Published: June 2012

AbstractDietary counselling and oral nutritional supplements (ONS) are recommended for managing malnutrition. A recent systematic review demonstrated (in separate analyses) that dietary counselling and dietary counselling with ONS improved energy intake, weight and some indices of body composition, although there was considerable heterogeneity. The present analysis aimed to examine the effects on mortality and nutritional indices of dietary counselling given with or without ONS and to explore the heterogeneity in the meta‐analyses aiming to characterise the groups most likely to benefit from these interventions. A systematic review and meta‐analysis was performed using Cochrane methodology. Twenty‐six studies were included in the analysis: 12 comparing dietary counselling with usual care and 14 comparing dietary counselling and ONS if required with usual care (2123 participants). Quality of studies varied. Dietary counselling given with or without ONS had no effect on mortality [relative risk (fixed) = 1.12; 95% confidence interval = 0.86–1.46] but was associated with significant but heterogeneous benefits to weight [mean difference (random) = 1.7 kg; 95% confidence interval = 0.86–2.55], energy intake and some aspects of body composition. Subgroup analyses taking into account clinical background, age, nutritional status, type and length of intervention failed to reveal any differences in mortality, weight change and energy intake between groups. There were insufficient data on functional outcomes to explore these findings. Dietary counselling given with or without ONS is effective at increasing nutritional intake and weight but adequately‐powered studies in similar patient populations and standardised for factors that might account for variations in response are required.
The holism of aesthetic knowing in nursing
Authors: Archibald Mandy M. 
Published: June 2012

AbstractIn 1978, Carper identified ‘four fundamental patterns of knowing’ that became largely foundational to subsequent epistemological discourse within the nursing discipline. These patterns of empirical, personal, aesthetic, and ethical knowing were presented as conceptually distinct yet related patterns of knowing. In order to provide an alternative conceptualization of aesthetics in nursing, the main tenants of Carper's discussion of aesthetic knowing will be revisited, and the foundations for her arguments will be examined. Specifically, Dewey's Art as Experience will be examined in relation to the ‘holism’ of nursing, and an alternative position on pragmatic aesthetics in nursing will be offered. A preliminary reintegration of the four patterns of knowing will then be presented as will an example of a potential cultivation of aesthetics in nursing, through an example of Rodin's 19th century sculpture, the Burghers of Calais.
Enhanced expression of glutamine synthetase (GS1a) confers altered fibre and wood chemistry in field grown hybrid poplar (Populus tremula X alba) (717‐1B4)
Authors: Coleman Heather D. , Cánovas Francisco M. , Man Huimin , Kirby Edward G. , Mansfield Shawn D. 
Published: June 2012

SummaryHybrid poplar (Populus tremula X P. alba) genetically engineered to express the pine cytosolic glutamine synthetase gene (GS1a) has been previously shown to display desirable field performance characteristics, including enhancements in growth and nitrogen use efficiency. Analysis of wood samples from a 3‐year‐old field trial of three independently transformed GS1a transgenic hybrid poplar lines revealed that, when compared with wild‐type controls, ectopic expression of GS1a resulted in alterations in wood properties and wood chemistry. Included were significant enhancements in wood fibre length, wood density, microfibre angle, per cent syringyl lignin and elevated concentrations of wood sugars, specifically glucose, galactose, mannose and xylose. Total extractive content and acid‐insoluble lignin were significantly reduced in wood of GS1a transgenics when compared with wild‐type trees. Together, these cell wall characteristics resulted in improved wood pulping attributes, including improved lignin solubilization with no concurrent decrease in yield. Trees with increased GS1a expression have improved characteristics for pulp and paper production and hold potential as a feedstock for biofuels production.
IgA anti‐epidermal transglutaminase autoantibodies: a sensible and sensitive marker for diagnosis of dermatitis herpetiformis in adult patients
Authors: Borroni G. , Biagi F. , Ciocca O. , Vassallo C. , Carugno A. , Cananzi R. , Campanella J. , Bianchi P.I. , Brazzelli V. , Corazza G.R. 
Published: June 2012

AbstractBackground  Dermatitis herpetiformis (DH) is a rare gluten‐sensitive blistering itchy skin disease, strictly related to coeliac disease (CD). Direct immunofluorescence, demonstrating IgA granular deposits localized either in the dermal papillae or along the dermo‐epidermal junction, is currently the gold standard for diagnosis of DH. It has been shown that DH immunocomplexes contain epidermal transglutaminase (eTG) and that sera from patients with DH contain antibodies specifically directed against eTG.Objectives  We studied the usefulness of serum eTG antibodies in discriminating between DH, CD and other gastrointestinal and dermatologic diseases.Methods  eTG antibodies were tested in 308 adult patients’ sera: 44 patients with untreated dermatitis herpetiformis (UDH), 99 patients with untreated coeliac disease (UCD), 70 dermatological controls and 95 gastrointestinal controls.Results  In UDH eTG antibody levels were significantly higher than in DH patients on gluten‐free diet, UCD, gastrointestinal controls and dermatological controls. In UCD eTG antibodies strongly correlated with tissue transglutaminase (tTG) antibodies, whereas in UDH no significant correlation was observed.Conclusion  Serum IgA eTG antibody determination can efficiently distinguish UDH from other dermatological itchy diseases and is highly sensitive to gluten‐free diet.
Etiological agents of superficial mycoses in Kayseri, Turkey
Authors: Kayman T. , Sarıgüzel F.M. , Koç A.N. , Tekinşen F.K. 
Published: June 2012

AbstractObjective  In this study, we aimed to determine the prevalence of agents that cause superficial mycoses and clinical types of superficial mycoses in terms of age and gender in our region were aimed.Methods  Five hundred samples of nails, skin and skin with hair taken from 476 children and adult patients pre‐diagnosed with superficial mycoses were examined by direct microscopy and cultural methods between October 2009 and October 2010.Results  Fungal elements were determined in 212 (42.4%) of the samples by using direct microscopy. Fungal growth was detected in 111 (22.2%) cultures of the same samples. It was found that the most common agents in superficial mycoses were Trichophyton rubrum (43.7%), Candida spp. (28%) and less often, Aspergillus spp., Malassezia spp., Saccharomyces spp., Rhodotorula spp., Trichosporon spp. and Trichophyton verrucosum.Conclusion  The significance of diagnosis by using direct microscopy and culturing together was again shown for the diagnosis of superficial fungal infections that follow a chronic course and affect the quality of life of patients. The most common agents in the superficial mycoses were T. rubrum. With this study, defining the aetiological agents of superficial mycoses in the Kayseri region is expected to contribute to the literature in terms of epidemiological data.