bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of dietary intervention on diabetic nephropathy: an umbrella review of systematic reviews and meta-analyses of randomized controlled trials
Authors: Cai Linli , Huang Yin , Li Xingyuan , Cao Dehong , Liu Fang 
Published: April 2024

ObjectiveTo evaluate the quality of evidence, potential biases, and validity of all available studies on dietary intervention and diabetic nephropathy (DN).MethodsWe conducted an umbrella review of existing meta-analyses of randomized controlled trials (RCTs) that focused on the effects of dietary intervention on DN incidence. The literature was searched via PubMed, Embase, Web of Science, and the Cochrane Database of Systematic Reviews. According to the Grading of Recommendations, Assessment, Development and Evaluation (GRADE), evidence of each outcome was evaluated and graded as “high”, “moderate”, “low” or “very low” quality to draw conclusions. Additionally, we classified evidence of outcomes into 4 categories.ResultsWe identified 36 meta-analyses of RCTs and 55 clinical outcomes of DN from 395 unique articles. Moderate-quality evidence suggested that probiotic supplementation could significantly improve blood urea nitrogen (BUN), total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels in DN patients. Low-quality evidence indicated that probiotic supplementation significantly improved the serum creatinine concentration, urinary albumin–creatinine ratio (UACR), fasting blood glucose (FBG), HbA1c and high-density lipoprotein cholesterol (HDL-C) in DN patients. In addition, low-quality evidence suggested that a salt restriction diet could significantly improve the creatinine clearance rate (CrCl) in patients with DN. Low-quality evidence suggested that vitamin D supplementation could significantly improve the UACR in patients with DN. In addition, low-quality evidence has indicated that soy isoflavone supplementation could significantly improve BUN, FBG, total cholesterol (TC), triglyceride (TG) and LDL-C levels in patients with DN. Furthermore, low-quality evidence suggested that coenzyme Q10 supplementation could significantly improve HbA1c, TC and HDL-C in patients with DN, and dietary polyphenols also significantly improved HbA1c in patients with DN. Finally, low-quality evidence suggested that supplementation with antioxidant vitamins could significantly improve the serum creatinine concentration, systolic blood pressure, and HbA1c level in patients with DN. Given the small sample size, all significantly associated outcomes were evaluated as class IV evidence.ConclusionModerate to low amounts of evidence suggest that supplementation with probiotics, vitamin D, soy isoflavones, coenzyme Q10, dietary polyphenols, antioxidant vitamins, or salt-restricted diets may significantly improve clinical outcomes in patients with DN.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42024512670.
Wind farm site selection using GIS-based mathematical modeling and fuzzy logic tools: a case study of Burundi
Authors: Placide Gatoto , Lollchund Michel Roddy 
Published: April 2024

Introduction: The electricity generated from nuclear plants and petroleum-based products has a negative influence on the environment as a whole. It has shown the utility to search out and promote the utilization of renewable, environmentally friendly, and sustainable energy sources such as solar, wind, and geothermal. Nowadays, Wind energy resource has quickly emerged as the world’s fastest-growing energy source.Methods: However, the selection of the most suitable places for developing a wind farm is a crucial challenge that can be seen as a problem of site selection, which involves numerous conflicting variables. Therefore, it is classified as an MCDM (multi-criteria decision-making) problem. The main objective of this research is to determine the best locations in Burundi for the installation of wind farms. The Fuzzy Analytic Hierarchy Process (FAHP) was used to weigh the criteria considering their relative importance. This study considers several key factors when determining the optimal location for a wind farm. These factors include wind speed, slope, proximity to the grid network, distance to roads, and land use/land cover (LULC). Furthermore, a geographic information system (GIS) is utilized to generate the final suitability wind farm locations map.Results and Discussion: The obtained results indicate that 20.91% of the whole study area is suitable nevertheless, only 1.96% is tremendously suitable for wind turbine placement. The western part of Burundi is the optimal area for constructing a wind farm, and the most is in Lake Tanganyika.
Myeloperoxidase induces monocyte migration and activation after acute myocardial infarction
Authors: Peters Vera B.M. , Matheis Friederike , Erdmann Immanuel , Nemade Harshal N. , Muders David , Toubartz Martin , Torun Merve , Mehrkens Dennis , Geißen Simon , Nettersheim Felix Sebastian , Picard Felix , Guthoff Henning , Hof Alexander , Arkenberg Per , Arand Birgit , Klinke Anna , Rudolph Volker , Hansen Hinrich Peter , Bachurski Daniel , Adam Matti , Hoyer Friedrich Felix , Winkels Holger , Baldus Stephan , Mollenhauer Martin 
Published: April 2024

IntroductionMyocardial infarction (MI) is a significant contributor to morbidity and mortality worldwide. Many individuals who survive the acute event continue to experience heart failure (HF), with inflammatory and healing processes post-MI playing a pivotal role. Polymorphonuclear neutrophils (PMN) and monocytes infiltrate the infarcted area, where PMN release high amounts of the heme enzyme myeloperoxidase (MPO). MPO has numerous inflammatory properties and MPO plasma levels are correlated with prognosis and severity of MI. While studies have focused on MPO inhibition and controlling PMN infiltration into the infarcted tissue, less is known on MPO’s role in monocyte function.Methods and resultsHere, we combined human data with mouse and cell studies to examine the role of MPO on monocyte activation and migration. We revealed a correlation between plasma MPO levels and monocyte activation in a patient study. Using a mouse model of MI, we demonstrated that MPO deficiency led to an increase in splenic monocytes and a decrease in cardiac monocytes compared to wildtype mice (WT). In vitro studies further showed that MPO induces monocyte migration, with upregulation of the chemokine receptor CCR2 and upregulation of inflammatory pathways identified as underlying mechanisms.ConclusionTaken together, we identify MPO as a pro-inflammatory mediator of splenic monocyte recruitment and activation post-MI and provide mechanistic insight for novel therapeutic strategies after ischemic injury.
Ultrastructural insights into cellular organization, energy storage and ribosomal dynamics of an ammonia-oxidizing archaeon from oligotrophic oceans
Authors: Zhou Yangkai , Yan An , Yang Jiawen , He Wei , Guo Shuai , Li Yifan , Wu Jing , Dai Yanchao , Pan Xijiang , Cui Dongyu , Pereira Olivier , Teng Wenkai , Bi Ran , Chen Songze , Fan Lu , Wang Peiyi , Liao Yan , Qin Wei , Sui Sen-Fang , Zhu Yuanqing , Zhang Chuanlun , Liu Zheng 
Published: April 2024

IntroductionNitrososphaeria, formerly known as Thaumarchaeota, constitute a diverse and widespread group of ammonia-oxidizing archaea (AOA) inhabiting ubiquitously in marine and terrestrial environments, playing a pivotal role in global nitrogen cycling. Despite their importance in Earth’s ecosystems, the cellular organization of AOA remains largely unexplored, leading to a significant unanswered question of how the machinery of these organisms underpins metabolic functions.MethodsIn this study, we combined spherical-chromatic-aberration-corrected cryo-electron tomography (cryo-ET), scanning transmission electron microscopy (STEM), and energy dispersive X-ray spectroscopy (EDS) to unveil the cellular organization and elemental composition of Nitrosopumilus maritimus SCM1, a representative member of marine Nitrososphaeria.Results and DiscussionOur tomograms show the native ultrastructural morphology of SCM1 and one to several dense storage granules in the cytoplasm. STEM-EDS analysis identifies two types of storage granules: one type is possibly composed of polyphosphate and the other polyhydroxyalkanoate. With precise measurements using cryo-ET, we observed low quantity and density of ribosomes in SCM1 cells, which are in alignment with the documented slow growth of AOA in laboratory cultures. Collectively, these findings provide visual evidence supporting the resilience of AOA in the vast oligotrophic marine environment.
Neurological manifestations of nontuberculous mycobacteria in adults: case series and review of the literature
Authors: Mina Yair , Kline Ahnika , Manion Maura , Hammoud Dima A. , Wu Tianxia , Hogan Julie , Sereti Irini , Smith Bryan R. , Zerbe Christa S. , Holland Steven M. , Nath Avindra 
Published: April 2024

IntroductionNontuberculous mycobacteria (NTM) mediated infections are important to consider in cases with neuroinflammatory presentations. We aimed to characterize cases of NTM with neurological manifestations at the National Institutes of Health (NIH) Clinical Center and review the relevant literature.Materials and methodsBetween January 1995 and December 2020, six cases were identified. Records were reviewed for demographic, clinical, and radiological characteristics. A MEDLINE search found previously reported cases. Data were extracted, followed by statistical analysis to compare two groups [cases with slow-growing mycobacteria (SGM) vs. those with rapidly growing mycobacteria (RGM)] and evaluate for predictors of survival. NIH cases were evaluated for clinical and radiological characteristics. Cases from the literature were reviewed to determine the differences between SGM and RGM cases and to identify predictors of survival.ResultsSix cases from NIH were identified (age 41 ± 13, 83% male). Five cases were caused by SGM [Mycobacterium avium complex (MAC) n = 4; Mycobacterium haemophilum n = 1] and one due to RGM (Mycobacterium abscessus). Underlying immune disorders were identified only in the SGM cases [genetic (n = 2), HIV (n = 1), sarcoidosis (n = 1), and anti-interferon-gamma antibodies (n = 1)]. All cases were diagnosed using tissue analysis. A literature review found 81 reports on 125 cases (SGM n = 85, RGM n = 38, non-identified n = 2). No immune disorder was reported in 26 cases (21%). Within SGM cases, the most common underlying disease was HIV infection (n = 55, 65%), and seizures and focal lesions were more common. In RGM cases, the most common underlying condition was neurosurgical intervention or implants (55%), and headaches and meningeal signs were common. Tissue-based diagnosis was used more for SGM than RGM (39% vs. 13%, p = 0.04). Survival rates were similar in both groups (48% SGM and 55% in RGM). Factors associated with better survival were a solitary CNS lesion (OR 5.9, p = 0.01) and a diagnosis made by CSF sampling only (OR 9.9, p = 0.04).DiscussionNTM infections cause diverse neurological manifestations, with some distinctions between SGM and RGM infections. Tissue sampling may be necessary to establish the diagnosis, and an effort should be made to identify an underlying immune disorder.
Risk factor of postoperative adverse events among children with duplex kidney undergoing upper pole heminephrectomy: a single-center experience
Authors: Wang Denghui , Cui Mengjie , Chu Xiangyang , Han Xiaojiang , Liu Pengpeng , Zhao Xiang , Fan Yingzhong 
Published: April 2024

ObjectiveThe aim of this study was to identify the risk factors for postoperative adverse events in children with duplex kidney undergoing upper pole heminephrectomy.MethodsWe collected clinical data from pediatric patients with duplex kidney who underwent upper pole heminephrectomy. Based on the presence or absence of postoperative adverse events, the patients were divided into two groups: an adverse events group (n = 16) and a non- adverse events group (n = 37), using multivariate logistic regression analysis to screen for independent risk factors for postoperative adverse events.ResultsThrough univariate and multivariate analysis, we found that the presence of upper renal ureterocele (P = 0.042, OR = 7.116, 95% CI 1.073–47.172), as well as the presence of accessory renal artery type (P = 0.016, OR = 10.639, 95% CI 1.551–72.978) and other types (P = 0.039, OR = 3.644, 95% CI 0.351–37.836) as the upper kidney's blood supply artery increase the risk of postoperative adverse events, with these differences being statistically significant.ConclusionsIn pediatric patients with duplex kidney undergoing upper pole heminephrectomy, the presence of upper renal ureterocele and the presence of accessory renal artery type and other types as the upper kidney's blood supply artery are independent risk factors for postoperative adverse events.
Effects of N application methods on cotton yield and fertilizer N recovery efficiency in salinity fields with drip irrigation under mulch film using 15N tracing technique
Authors: Luo Zhen , Tang Wei , Wang Xiaowen , Lu Hequan , Li Chenyang , Liang Jun , Kong Xiangqiang 
Published: April 2024

IntroductionDrip irrigation under mulch film promotes a non-uniform salinity distribution in salt fields. The effect of different N application methods on the growth and yield of cotton under drip irrigation under mulch film conditions in eastern coastal saline-alkaline soils in China remain remained unclear.MethodsA randomized complete block design was used in the experiment. Three N application methods were assigned: N applied under mulch film (low-salinity area; UM), N applied between mulch films (high-salinity area; BM), and half N applied under mulch film and half between mulch films (HUHB).ResultsPlant height, photosynthesis, Chl content, boll load, biomass, boll weight and boll density under UM were all significantly higher than those under the other two treatments. The N absorption of UM was higher than in the other two treatments, which might be attributed to the expression of GHNRT1.5 and GHNRT2.1. The net NO3- influx in the roots in UM increased significantly compared with that in BM. The yield and FNRE of UM were 3.9% and 9.1%, respectively, and were 26.52% and 90.36% higher than under HUHB and BM treatments.DiscussionUM not only improved cotton yield but also alleviated the pollution of N residue on drip irrigation under mulch film conditions in salt areas.
Development and validation of Adaptability to Return-to-Work Scale (ARTWS) for cancer patients
Authors: Guo Yu-Jie , Xue Ping , Gu Wen-wen , Su Xiao-qin , Li Jia-mei , Kuai Ben-xin , Xu Jia-shuo , Xie Hui-wen , Han Ping-ping 
Published: April 2024

IntroductionThe research on cancer patients returning to work in China is still in its infancy, and there is no research and discussion on the adaptability to return-to-work for cancer patients. It is critical to develop the Adaptability to Return-to-Work Scale (ARTWS) for cancer patients and evaluate its psychometric properties.MethodsThe items of the initial scale were compiled based on the theoretical model and literature review results. Through two rounds of Delphi expert consultation (N = 15) and a pilot survey (N = 40), the initial scale was further checked and revised. Conduct a large sample survey (N = 376) and the construct validity and reliability of the ARTWS were assessed by confirmatory factor analysis (CFA) and exploratory factor analysis (EFA).ResultsThe final ARTWS consisted of 24 items. “Focusing on rehabilitation,” “Rebuilding Self-efficiency,” and “Adjusting plans” as common factors in determining adaptability to return to work for cancer patients, and the cumulative variance contribution rate for these three factors was 66.6%. The S-CVI of the total scale was 0.979. The Cronbach’s α coefficient was 0.937 and the 2-week test–retest reliability was 0.814.DiscussionARTWS has good correlation validity and can be used as a tool to measure the adaptability of cancer patients’ return to work. The presentation of the manuscript in Research Square (https://doi.org/10.21203/rs.3.rs-2323264/v1).
Physical activity and school adaptation among Chinese junior high school students: chain mediation of resilience and coping styles
Authors: Wu Xinbo , Liang Junwen , Chen Jiaxi , Dong Weixin , Lu Chunxia 
Published: April 2024

BackgroundAs a crucial juncture in students’ educational journey, junior high school presents challenges that profoundly influence well-being and academic performance. Physical activity emerges as a pivotal factor shaping the holistic development of junior high school students. Beyond its recognized impact on physical and mental health, engaging in regular physical activity proves effective in augmenting students’ adaptability to school life. Despite its importance, the mechanisms through which physical activity influences school adaptation in junior high school students remain understudied in academic research.ObjectiveIn exploring the potential mechanisms, this study aims to validate the mediating roles of resilience and coping styles by examining the association between physical activity and school adaptation among junior high school students.MethodsThis study employed cross-sectional survey approach among junior high school students in China. Through the convenience sampling, 1,488 participants aged from 12 to 16 years old (Average age = 13.59, SD = 1.017) from two Junior high schools in Changsha City, Hunan Province were recruited to complete the Physical Activity Scale, School Adaptation Questionnaire for Junior High School Students, Resilience Scale for Adolescents, and Simple Coping Styles Questionnaire. For data analysis, the SPSS 26.0 and Amos 26.0 were used for statistical processing.ResultsThe results showed that physical activity exhibited a significant correlation with school adaptation (r = 0.656, p &lt; 0.001). Resilience, positive coping style and negative coping style played partial mediating roles between physical activity and school adaptation, with the effect size were 0.229, 0.170, 0.171. The chain mediation effect size of resilience and positive coping style was 0.042, while the chain mediation effect size of resilience and negative coping style was 0.050.ConclusionPhysical activity positively predicts Chinese junior high school students’ school adaptation through resilience and coping styles, suggesting that junior high school students should engage in regular physical activity, so as to improve their resilience and positive coping styles, mitigating negative coping styles, thus promoting their school adaptation.
How did you perform? Investigating football players’ perception of self-regulated passing performances under auditory noise environments
Authors: Klatt Stefanie , Otte Fabian Werner , Beavan Adam , Schumacher Tom , Millar Sarah Kate 
Published: April 2024

IntroductionThis paper deals with the question on how sport performances may be influenced by internal, emotional processes, which stem from outside feedback.MethodsIn terms of methods, players’ subjective performance ratings for four experimental auditory cue conditions were examined; these included both ‘positive’ and ‘negative’ stadium noise, ‘no (auditory) conditions,’ and a control/‘baseline’ condition. This resulted in a qualitative-analytic data set that was obtained succeeding each auditory cue condition using a unique football training machine (i.e., known as ‘Footbonaut’). Without having received any coaching/performance feedback, players were asked to rate and individually comment on their perceived performance ratings for each experimental auditory condition.ResultsFindings indicate stronger and more significant correlations between auditory conditions and subjective ratings compared to the non-auditory condition and its subjective rating. Furthermore, data provides initial insight into players’ emotional experiences during each of the practice conditions.DiscussionThese noteworthy findings on players’ abilities to accurately judge their performances based on selfmonitoring and intrinsic feedback are discussed from an Ecological Dynamics perspective, linked to a Nonlinear Pedagogy for coaching. Here, representative and affective learning designs for skill learning and performance preparation are presented. Finally, a hypothetical catalyst effect of auditory stadium noise on subjective performance rating is proposed.
Time trends in surgical provision and cancer-specific outcomes in patients with stage T2-3 kidney cancer: a SEER-based study
Authors: Song Zhuo , Xing Jizhang , Sun Zhijia , Kang Xiaoli , Li Hongzhao , Ren Gang , Wang Yingjie 
Published: April 2024

Background and objectiveSurgery is the primary therapy that crucially affects the survival of patients with kidney cancer (KC). However, pertinent surgical decision criteria for individuals with stage T2-3 KC are lacking. This study aimed to display the practical choices and evolving trends of surgical procedures and elucidate their implied value.MethodsThrough the Surveillance, Epidemiology, and End Results (SEER) dataset, the levels and evolving trends of different surgical methods were examined to determine cancer-specific risk of death (CSRD). Additionally, stratification analysis and survival rate analysis were performed to explore the effectiveness of partial nephrectomy (PN).ResultsIn this study, 9.27% of patients opted for PN. Interestingly, an upward trend was observed in its decision, with an average annual percentage change (AAPC) of 7.0 (95% CI: 4.8–9.3, P &lt; 0.05). Patients who underwent PN and were in a relatively less severe condition exhibited more favorable CSRD levels (0.17–0.36 vs. 0.50–0.67) and an improvement trend compared with those who underwent radical nephrectomy (RN) (AAPC: −1.9 vs. −0.8). Further analysis showed that the levels of CSRD and survival rates for patients opting for different surgical methods followed a similar pattern.ConclusionsThis study showed that RN was still the most common surgical method. Patients with stage T2-3 KC had an increasing preference for PN and exhibited more favorable cancer-related survival outcomes, which underscores the need for further investigation and validation.
Navigating HIV-Related Stigma in Switzerland: A Qualitative Study
Authors: Gilles Ingrid , Jackson-Perry David , Le Saux Clara , Storari Chiara , Cart-Richter Ellen , Keserue Pittet Oriana , Darling Katharine E. A. 
Published: April 2024

Objectives: This study sought to understand how people living with HIV experience, perceive, and navigate stigma in their everyday life and in care settings in an urban French-speaking area in Switzerland.Methods: Semi-structured interviews were carried out with 19 people living with HIV in Lausanne concerning their experience of HIV-related stigma in both everyday life and in healthcare settings. Content analysis was performed to identify main and sub-themes.Results: “Living with HIV” posed little or no difficulty for participants. However, the burden of anticipated and internalized HIV-related stigma played a disproportionately large role in their lives. Participants considered the general population’s low level of knowledge about HIV as problematic in this regard. While participants reported few examples of enacted stigma generally, healthcare environments were sometimes experienced as sites of prejudice and discrimination. However, some healthcare professionals were also sources of information and knowledge, contributing to participants’ “journeys of self-acceptance.”Conclusion: Even in an urban environment in a country with ready access to healthcare and education, HIV-related stigma remains a concern for people living with HIV.