bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Reduction of Oximes with Sodium Borohydride—Copper(II) Sulfate in Methanol.
Authors: Rao H. Surya Prakash , Bharathi B. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Ene‐Type Chlorination of Functionalized Olefins Using Sulfuryl Chloride in the Absence of a Base.
Authors: Bhamare Nana K. , Lai Gaifa , Anderson Wayne K. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: 3‐Phosphono‐2‐(N‐cyanoimino)thiazolidine Derivatives, New Phosphorylating Agents for Alcohols.
Authors: Maezaki Naoyoshi , Furusawa Akemi , Hirose Yuki , Uchida Shuji , Tanaka Tetsuaki 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: New Approaches to High‐Activity Transition‐Metal Catalysts for Carbon—Carbon Bond Forming Reactions. Rhenium‐Containing Phosphorus Donor Ligands for Palladium‐Catalyzed Suzuki Cross‐Couplings.
Authors: Eichenseher Sandra , Kromm Klemenz , Delacroix Olivier , Gladysz J. A. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
“The β1‐selective adrenoceptor agonist dobutamine”: A fallacy being perpetuated
Authors: Waldeck Bertil 
Published: June 2010

AbstractDobutamine is a cardiotonic agent, developed as a racemate more than 30 years ago. The compound soon got the label “the β1‐selective adrenoceptor agonist”. However, a closer examination of the enantiomers showed that (+)‐dobutamine is predominantly a β1‐ and β2‐adrenoceptor agonist with modest selectivity whereas (−)‐dobutamine is predominantly an α1‐adrenoceptor agonist. Nevertheless,racdobutamine is still frequently used as a tool for classification of β‐adrenoceptors. This ignorance of chiralilty may lead to erroneous conclusions and consolidate false labels. Chirality, 2011. © 2010 Wiley‐Liss, Inc.
100 Jahre Bakelit
Authors: Braun Dietrich , Collin Gerd 
Published: June 2010

AbstractAuf der Suche nach einem Ersatz für das Naturprodukt Schellack entstand vor rund 100 Jahren mit dem synthetischen “Bakelit” eine neue und die zugleich jüngste Werkstoffklasse der Menschheit, die unserer Zeit technisch und kulturell ihren Stempel aufgedrückt hat. Die Erfindung der duroplastischen (härtbaren) Bakelite‐Harze durch dem flämischen Chemiker Leo Hendrik Baekeland aus Steinkohlenteer‐Phenol und Formaldehyd markiert den Beginn des “Zeitalters der Kunststoffe” im 20. Jahrhundert.
Häcksler bekommt Nebenjob
Authors: Groß Michael 
Published: June 2010

AbstractEin Enzym namens Dicer (nach einem Küchenwerkzeug zum Gemüsehäckseln) zerschnipselt normalerweise RNA‐Moleküle, was sowohl in der Natur als auch im Labor dem zeitweiligen Ausschalten von Genen dienen kann. Völlig überraschend kam nun der Befund, dass Würmer den RNA‐Häcksler auf DNA umschalten und im programmierten Zelltod einsetzen können.
Intra‐arterial iodine‐131‐lipiodol for unresectable hepatocellular carcinoma
Authors: Chua Terence C. , Chu Francis , Butler S. Patrick , Quinn Richard J. , Glenn Derek , Liauw Winston , Morris David L. 
Published: June 2010

AbstractBACKGROUND:Hepatic artery administration of iodine‐131‐Lipiodol serves as a modality that delivers targeted radiation therapy to hepatocellular carcinoma. Its efficacy has been promising according to trials conducted in the adjuvant setting after hepatic resection. Further investigation of its role in the palliative setting is warranted.METHODS:A retrospective review of 72 patients with unresectable hepatocellular carcinoma treated with iodine‐131‐Lipiodol and followed up by the St. George Hospital Sydney's hepatobiliary service was conducted. Efficacy of treatment was determined based on progression‐free and overall survival as the endpoints using the Kaplan‐Meier method.RESULTS:Sixty men and 12 women with a mean age of 65 years (standard deviation = 11) underwent iodine‐131‐Lipiodol treatment. Chronic viral hepatitis was present in 29 (41%) patients. Fifty (69%) patients were Child‐Pugh class A. Median progression‐free survival was 6 months, and overall survival was 14 months; the 1‐, 2‐, and 3‐year survival rates were 52%, 33% and 20%, respectively. Factors associated with survival include the American Joint Committee on Cancer stage (P = .03), Barcelona Clinic Liver Cancer stage (P = .05), Cancer of the Liver Italian Program score (P = .008), tumor size (P = .01), extrahepatic disease (P < .001), previous surgery (P = .02), and response to treatment (P < .001). The response to treatment was identified through a multivariate analysis as the single independent predictor for survival (hazard ratio, 3.5; 95% confidence interval, 2.2‐5.4; P < .001).CONCLUSIONS:Encouraging survival outcomes may be derived through administration of iodine‐131‐Lipiodol in patients with unresectable hepatocellular carcinoma. The overall success of treatment may be determined by the response to treatment. Cancer 2010. © 2010 American Cancer Society.
Timing of palliative care referral and symptom burden in phase 1 cancer patients
Authors: Hui David , Parsons Henrique , Nguyen Linh , Palla Shana L. , Yennurajalingam Sriram , Kurzrock Razelle , Bruera Eduardo 
Published: June 2010

AbstractBACKGROUND:Phase 1 trials offer patients with advanced cancer the opportunity to pursue life‐prolonging cancer treatments. In the current study, the timing of referral and symptom burden between patients referred to palliative care by phase 1 oncologists and those referred by non‐phase 1 oncologists were compared.METHODS:All 57 patients with advanced solid tumors who were referred by phase 1 oncologists to the palliative care outpatient clinic at The University of Texas M. D. Anderson Cancer Center (MDACC) between 2007 and 2008 were included. The comparison cohort was comprised of 114 non‐phase 1 patients who were stratified by age, sex, and cancer diagnosis in a 1:2 ratio. Information regarding patient characteristics, Edmonton Symptom Assessment Scale (ESAS), timing of referral, and survival was retrieved.RESULTS:Both cohorts had the following matched characteristics: average age of 57 years, with44% of the patients being female and 47% having gastrointestinal cancers. At the time of palliative care consultation, patients referred by phase 1 oncologists were more likely than patients referred by non‐phase 1 oncologists to have a better performance status (Eastern Cooperative Oncology Group 0–1: 61% vs 36% [P = .003). The ESAS was not significantly different with the exception of better well‐being in the phase 1 cohort (mean, 4.5 vs 5.5; P = .03). No difference was found for the duration between registration at MDACC and palliative care consultation (13 months vs 11 months; P = .41) and overall survival from the time of palliative care consultation (5 months vs 4 months; P = .69).CONCLUSIONS:Outpatients referred to palliative care by phase 1 oncologists were found to have a better performance status but similar symptom burden compared with patients referred by non‐phase 1 oncologists. Patients with phase 1 involvement did not appear to have delayed palliative care referral compared with non‐phase 1 patients. The results of the current study support the development of a simultaneous care model. Cancer 2010. © 2010 American Cancer Society.
Renewed Insight into the Promoting Mechanism of Magnesium Hydride on Ammonia Borane
Authors: Luo Junhong , Kang Xiangdong , Wang Ping 
Published: June 2010

AbstractOur previous study found that mechanically milling with magnesium hydride (MgH2) could dramatically improve the dehydrogenation property of ammonia borane (AB). Meanwhile, it appears that the MgH2 additive maintains its phase stability in the milling and subsequent heating process. In an effort to further the mechanistic understanding of the AB/MgH2 system, we reinvestigated the property and structure evolution in the hydrogen release process of the AB/0.5MgH2 sample. Property examination using volumetric method and synchronous thermal analyses showed that the AB/0.5 MgH2 sample releases ∼13.8 wt % hydrogen after being heated at 300 °C. This hydrogen amount is in excess of that available from AB, indicative of the participation of a faction of MgH2 in the dehydrogenation process of AB. Structural and chemical state analyses using Fourier transformation infrared spectroscopy and solid‐state 11B nuclear magnetic resonance techniques further showed that part of MgH2 participates in the dehydrogenation process of AB from the first step, resulting in the formation of MgBNH intermediate species. The incorporation of Mg in AB is believed to be a crucial event leading to dehydrogenation property improvements, particularly for the release of the last equivalent of H2 in AB at relatively moderate temperature. These findings have provided renewed insight into the promoting mechanism of MgH2 on the hydrogen release from AB.
A 120–420 MHz delay‐locked loop with multi‐band voltage‐controlled delay unit
Authors: Kuo Ko‐Chi , Hsu Yi‐Hsi 
Published: June 2010

SUMMARYA low‐jitter and low‐power dissipation delay‐locked loop (DLL) is presented. A proposed multi‐band voltage control delay unit (MVCDU) is employed to extend the operation frequency of the DLL by controlling the delay cell within the MVCDU. The jitter of DLL is reduced due to MVCDU's low sensitivity. The delay cell in the MVCDU employs a differential configuration to further reduce the noise impact from the fluctuation in the supply and ground voltage. The operating frequency of the proposed DLL ranges from 120 to 420 MHz. The proposed design has been fabricated in a TSMC 0.18µm CMOS process. The measured RMS and peak‐to‐peak jitters are 4.86 and 34.55 ps, respectively, at an operating frequency of 300 MHz. The power dissipation is below 14.85 mW at an operating frequency of 420 MHz. Copyright © 2010 John Wiley & Sons, Ltd.
Levels of circulating endothelial cells in normotensive and severe preeclamptic pregnancies
Authors: Strijbos Michiel H. , Snijder Claudia A. , Kraan Jaco , Lamers Cor H. J. , Gratama Jan W. , Duvekot Johannes J. 
Published: June 2010

AbstractBackground:Preeclampsia is a disease hypothesized to originate from widespread endothelial dysfunction or damage. This study investigated whether circulating endothelial cells (CEC) can serve as a surrogate marker for disease severity in patients with preeclampsia, and if their number correlates to serum endothelial biomarkers for activation, dysfunction, or damage of those cells.Methods:Blood was drawn consecutively from 30 patients admitted with a diagnosis of severe preeclampsia. Thirty healthy, normotensive, patients matched for age, body mass index, and gestational age served as a control group. We determined the number of CEC and serum concentrations of biomarkers indicative of endothelial damage (thrombomodulin) and activation (E‐selectin), and the antiangiogenic protein (endoglin), which reflects endothelial dysfunction.Results:Median CEC counts did not differ significantly between preeclamptic patients and the control group (median 5.3 vs. 3.5 CEC/mL, respectively) and were mostly within the normal range (i.e., <20 CEC/mL). However, serum concentrations of thrombomodulin (median 3.6 vs. 5.2 ng/mL; P = 0.006), E‐selectin (median 32.0 vs. 42.9 ng/mL; P = 0.02), and especially endoglin (median 5.0 vs. 76.2 ng/mL; P < 0.0001) were significantly increased in severe preeclamptic patients. CEC counts did not correlate with any of the clinical parameters or routinely determined laboratory indices.Conclusion:Preeclampsia is characterized by endothelial dysfunction and activation rather than actual endothelial damage as characterized by increased CEC counts. © 2010 International Clinical Cytometry Society
Opioid mediation of amniotic fluid effects on chemosensory responsiveness in the neonatal rat
Authors: Méndez‐Gallardo Valerie , Robinson Scott R. 
Published: June 2010

AbstractThe present study investigated if oral exposure to milk or amniotic fluid (AF) alters responsiveness to sensory stimulation in the neonatal rat, and whether these effects are mediated by the opioid system. Facial wiping evoked by intraoral lemon infusion was used as a measure of sensory responsiveness. Pups were tested in a supine posture, because they showed more paw‐face strokes during facial wiping than pups tested prone (Experiment 1). Moreover, pups orally exposed to milk (Experiment 2) or AF (Experiment 3) showed a diminished wiping response to lemon compared to controls exposed to water. Blockade of opioid receptors with the nonselective antagonist naltrexone (Experiment 4) or the kappa antagonist nor‐binaltorphimine (Experiment 5) reinstated higher levels of facial wiping after AF exposure. These findings confirm developmental continuity between fetal and neonatal behavioral responses to AF and the ability of AF to induce activity at kappa receptors of the endogenous opioid system. © 2010 Wiley Periodicals, Inc. Dev Psychobiol 52: 740–754, 2010.
Neuroplasticity of the central hypercapnic ventilatory response: Teratogen‐induced impairment and subsequent recovery during development
Authors: Brundage Cord M. , Taylor Barbara E. 
Published: June 2010

AbstractNeuroventilation is highly plastic and exposure to either of two distinct teratogens, nicotine or ethanol, during development results in a similar loss of the neuroventilatory response to hypercapnia in bullfrog tadpoles. Whether this functional deficit is permanent or transient following nicotine or ethanol exposure was unknown. Here, we tested the persistence of hypercapnic neuroventilatory response impairments in tadpoles exposed to either 30 μg/L nicotine or 0.12–0.06 g/dL ethanol for 10 weeks. Brainstem breathing‐related neural activity was assessed in tadpoles allowed to develop teratogen‐free after either nicotine or ethanol exposure. Nicotine‐exposed animals responded normally to hypercapnia after a 3‐week teratogen‐free period but the hypercapnic response in ethanol‐exposed tadpoles remained impaired. Tadpoles allowed to develop for only 1 week nicotine free after chronic exposure were unable to respond to hypercapnia. The hypercapnic response of ethanol‐exposed tadpoles returned by 6 weeks following chronic ethanol exposure. These findings suggest that some nicotine‐ and ethanol‐induced impairments can be resolved during early development. Understanding both the disruptive effects of nicotine and ethanol exposure and how impaired responses return when teratogen exposure stops may offer insight on the function and plasticity of respiratory control. © 2010 Wiley Periodicals, Inc. Develop Neurobiol 70: 726–735, 2010
Three consecutive generations of nephridia occur during development of Platynereis dumerilii (Annelida, Polychaeta)
Authors: Hasse Christian , Rebscher Nicole , Reiher Wencke , Sobjinski Kathrin , Moerschel Erhard , Beck Lothar , Tessmar‐Raible Kristin , Arendt Detlev , Hassel Monika 
Published: June 2010

AbstractMolecular data for nephridial development in polychaetes are not available yet. The scope of our work was to establish a reference system for future investigations using two markers for nephridial development: β‐tubulin as marker for cilia and alkaline phosphatase (AP) activity for secretory epithelia. The markers identified, unexpectedly, three consecutively forming generations of nephridia: (1) a transitory unciliated, but AP‐positive head kidney, (2) a transitory larval nephridium, which undergoes a morphological transition from a protonephridium to a funnelled nephridium concomitant with the development of the coelomic cavity and finally, (3) the serially arranged metanephridia. The spatial arrangement of larval and definitive nephridia, revealed an up to now unknown developmental boundary between the synchronously forming larval and the serially proliferating definitive segments. Development of three consecutive sets of nephridia with different morphology and biochemical properties was unexpected and reveals an interesting multistep process in the development of excretory structures in Platynereis. Developmental Dynamics 239:1967–1976, 2010. © 2010 Wiley‐Liss, Inc.
Unexpected Oxidative Dimerisations of a Cyclopentadienyl‐Phosphane – Formation of Unprecedented, Structurally Remarkable Phosphacyclic Compounds
Authors: Lichtenberg Crispin , Elfferding Michael , Sundermeyer Jörg 
Published: June 2010

AbstractThe reactions of Me2PCp# (1) (Cp# = C5HMe4) with Ph3PCH2X+ X–(X = Cl, Br, I) and diiodomethane as potential electrophiles have been investigated. Unexpectedly, in all four cases unprecedented oxidative dimerisations of the cyclopentadienylphosphane 1 have been observed. In the reactions with the phosphonium salts, an ionic group 15 analogue of octamethyl‐tetrahydro‐s‐indacene with different counterions X– has been obtained (5–7) as a result of X+ transfer and H+ elimination. In the reaction of 1 with diiodomethane a fourfold anellated, partially unsaturated, heterocyclic compound 9 exhibiting two spiro carbon centres, which are directly linked, was formed, presumably as a result of iodine radical transfer. Both of the novel phosphorus heterocycles have been characterised by means of single crystal XRD analysis.
Macrocyclic 14‐Membered‐Ring Diketal Dilactams: Spectroscopic Studies and Conformational Analysis of Their Complexes with Divalent Cations
Authors: Valade Anne‐Gaëlle , Harakat Dominique , Guyot Jacques , Laprévote Olivier , Dugat Denise 
Published: June 2010

AbstractThe complexation behaviour of four new 14‐membered‐ring diketal dilactam macrocycles towards some divalent cation perchlorates has been investigated. Stoichiometries and binding constants were determined by 1H NMR titration experiments. The structures of the complexes were studied by IR, NMR (1H and 13C) and electrospray mass spectrometry. 13C longitudinal relaxation time data allowed identification of the donor atoms involved in the complexation and provided information on the intramolecular mobility of the complexed ligands. Molecular modelling was also used to gain further insights into the conformational changes undergone by these molecules as a result of metal ligation. It was found that i. the macrocycles formed complexes of essentially 1:1 stoichiometry in the binding order Sr2+ ≥ Ca2+ > Mg2+ > Ba2+, ii. the coordination process caused conformational changes that resulted in cleavage of the hydrogen bonds in the ligand structure and a new orientation of the NH–CO bonds and iii. the coordination of the cations involved either all six oxygen atoms of the ligands or five of them, depending on whether the OMe groups were cis or trans, and probably two oxygen atoms from the ClO4– counter‐anion.
Linear Tetranickel String Complexes with Mixed Supported Ligands and Mixed‐Valence Units [Ni2]3+: Synthesis, Crystal Structure, and Magnetic Studies
Authors: Yeh Che‐Wei , Liu Isiah Po‐Chun , Wang Rui‐Ren , Yeh Chen‐Yu , Lee Gene‐Hsiang , Peng Shie‐Ming 
Published: June 2010

AbstractThe synthesis, crystal structures, and magnetic properties of linear tetranickel string complexes supported by mixed 2‐(α‐pyridylamino)‐1,8‐naphthyridine (Hpyany) and N‐(p‐tolylsulfonyl)dipyridyldiamine (H2tsdpda) ligands are reported. In comparing the crystal structure of [Ni4(pyany)2(tsdpda)2Cl] (1) with that of [Ni4(pyany)2(tsdpda)2Cl(H2O)](PF6) (2), the one‐electron‐reduced compound 1 displays shorter Ni(3)–Ni(4) (ca. 2.28 Å) and longer Ni(3)–N (ca. 2.02 Å) bond lengths. Similar trends have also been observed for axial NCS–‐substituted derivatives [Ni4(pyany)2(tsdpda)2(NCS)] (3) and [Ni4(pyany)2(tsdpda)2(NCS)2] (4). These structural variations indicate the formation of a mixed‐valence [Ni2]3+ unit and a three‐electron, two‐center Ni(4)–Ni(3) σ bond. Magnetic measurements of 2 and 4 show that both terminal Ni(1) and Ni(4) ions are in the high‐spin states (S = 1) and are antiferromagnetically coupled. The one‐electron‐reduced complexes 1 and 3, however, exhibit a delocalized mixed‐valence [Ni2]3+ unit (S = 3/2), which is antiferromagnetically coupled with the terminal high‐spin NiII ion.
Strong Circularly Polarized Luminescence from Highly Emissive Terbium Complexes in Aqueous Solution
Authors: Samuel Amanda P. S. , Lunkley Jamie L. , Muller Gilles , Raymond Kenneth N. 
Published: June 2010

AbstractTwo luminescent terbium(III) complexes have been prepared from chiral ligands containing 2‐hydroxyisophthalamide (IAM) antenna chromophores and their non‐polarized and circularly‐polarized luminescence properties have been studied. These tetradentate ligands, which form 2:1 ligand/TbIII complexes, utilize diaminocyclohexane (cyLI) and diphenylethylenediamine (dpenLI) backbones, which we reasoned would impart conformational rigidity and result in TbIII complexes that display both large luminescence quantum yield (Φ) values and strong circularly polarized luminescence (CPL) activities. Both TbIII complexes are highly emissive, with Φ values of 0.32 (dpenLI‐Tb) and 0.60 (cyLI‐Tb). Luminescence lifetime measurements in H2O and D2O indicate that while cyLI‐Tb exists as a single species in solution, dpenLI‐Tb exists as two species: a monohydrate complex with one H2O molecule directly bound to the TbIII ion and a complex with no water molecules in the inner coordination sphere. Both cyLI‐Tb and dpenLI‐Tb display increased CPL activity compared to previously reported TbIII complexes made with chiral IAM ligands. The CPL measurements also provide additional confirmation of the presence of a single emissive species in solution in the case of cyLI‐Tb, and multiple emissive species in the case of dpenLI‐Tb.
Preparation of Highly Hindered Polyenynes
Authors: Kiliçkiran Pinar , Hopf Henning , Dix Ina , Jones Peter G. 
Published: June 2010

AbstractThe terminal enynes 10–12 were prepared from the corresponding aldehydes 6–8 by applying conventional methods of acetylene chemistry. After exploratory study of the reactivity of these hydrocarbons (preparation of 13, 18, and 19 from 10) these building blocks were subsequently oxidatively dimerized (Glaser coupling) to the sterically protected oligoenynes 22–25; McMurry coupling of 13 yielded 26 as a mixture of diastereomers. Whereas 22 is inert towards sodium sulfide the higher vinylogs/ethynylogs 23–25 furnished the novel thiophene derivatives 28–31. The structures of several (22–25, 28, 29) of the new highly unsaturated compounds were determined by single‐crystal X‐ray structural analysis.
A DFT Study of 1,4‐Biradical Intermediates Involved in Stereoselective Paternò–Büchi Reactions
Authors: D'Auria Maurizio , Racioppi Rocco 
Published: June 2010

AbstractThe stereoselectivity of the reaction of silyl enol ethers with benzaldehyde is explained by using DFT calculations, considering the relative stability of the possible stereoisomers of the biradical intermediates and the coupling between the single occupied molecular orbitals (SOMOs) of these intermediates. The same approach can be used to justify the observed endo stereoselectivity in the reaction of 2,3‐dihydrofuran with 2,4,6‐trimethylbenzaldehyde and the exostereoselectivity in the reaction of the same substrate with 2‐naphthaldehyde.