bluuebunny/crossref_metadata_2025_split huggingface dataset:
The genus <i>Trichaptum</i> in North Asia
Authors: Mukhin V. A. , Knudsen H. , Corfixen P. , Zhuykova E. V. , Nepryakhin I. O. , Diyarova D. K. 
Published: April 2024

It is shown that in North Asia (Urals, Siberia, Far East) the genus Trichaptum is represented by four widespread sympatric species (Trichaptum abietinum, T. biforme, T. fuscoviolaceum, T. laricinum) and T. quercinum found in the Far East. The geographic range of T. fuscoviolaceum, T. abietinum, T. biforme cover the whole of North Asia, whereas T. laricinum is absent in the Far East. The revealed sympatric nature of species is based on their predominant use of wood various coniferous (T. fuscoviolaceum, T. abietinum, T. laricinum) and deciduous (T. biforme) tree species. The widest trophic niche is in T. fuscoviolaceum and it overlaps by 70–80% with the niches of T. abietinum, T. laricinum. The narrowest trophic niche that does not overlap with other species of the genus is in T. biforme. The trophic spectra and preferences of all species in North Asia are close to those in Europe, and it shows stability and species specificity of these ecological characteristics. Phylogenetically, T. abietinum and T. fuscoviolaceum are the closest in ITS and LSU rDNA regions, while T. biforme and T. laricinum are strongly and equally distant from each other and from T. abietinum and T. fuscoviolaceum. During ITS and LSU clustering, the sequences are grouped in full accordance with the hymenophore structure of the fungi from which they were isolated; the same groups also include sequences of the corresponding fungi from Europe, China, and North America. This shows that in T. fuscoviolaceum, T. abietinum, T. biforme, T. laricinum, the structure of the hymenophore is a good diagnostic species character, and also that their North Asian populations do not show significant differences from European and North American populations. A database on diversity, distribution, ecology of fungi of the genus Trichaptum in North Asia has been uploaded to GBIF for public access.
The Functional State of Emotion-Motivational Brain Regulatory Systems and Risk-Taking Propensity in Adolescents
Authors: Lomakin D. I. 
Published: April 2024

The aim of this study was to identify relationships between the functional state of the different brain regulatory systems (BRS), voluntary control and emotional-motivational regulation in adolescents (n = 95, age ~13.96 ± 1.13, girls 34%). We also analyzed the relationship between individual characteristics of emotional-motivational regulation and risk-taking tendencies in separated groups with specific EEG signs of suboptimal functional state of the BRS. Five tests were performed: 1) assessment of individual traits of achievement motivation vs. failure avoidance using the Mehrabian Questionnaire (TMD), 2) emotional intelligence (EI) using the MSCEIT 2.0, 3) assessment of propensity to risky decision-making by monetary computer game Baloon Analog Risk Task. On the basis of a qualitative analysis of the EEG, 4) the participants were classified into groups showing evidence of suboptimal functioning of the frontothalamic (FTS), limbic (LMB), frontobasal (FBZ) and to control group in the case of absence of specific signes. All groups, except control, showed a decrease in the EI scale, which associate sensations with emotions. A specific decrease in EI indicators was found in experimental groups in comparison with the control group: FTS – on the scale of understanding blended emotions; LMB — on the scale of facilitation of cognitive activity by emotions; FBZ group — on a scale reflecting the ability to manage one’s own emotions. The indicators of the Mehrabian questionnaire showed propensity towards achievement motivation in the LMB. Correlations between EI, achievement motivation and risk-taking: in FTS, LMB a positive correlation of the risk-taking with the scale associate sensations with emotions. For LMB there is also a positive correlation between risk-taking, understanding and management of emotions. The results are discussed in terms of the influence of the suboptimal state of brain regulatory systems on the emotional and motivational regulation in adolescents.
Recovery of the Functional Activity of K<sub>ATP</sub>-Channels of Pial Arteries after Ischemia/Reperfusion Using Cell Therapy
Authors: Sokolova I. B. , Gorshkova O. P. 
Published: April 2024

This study aims to examine the efficiency of intravenous transplantation of human mesenchymal stem cells (hMSCs) performed 7 days after cerebral ischemia/reperfusion (I/R) for recovery of the functional activity of KATP-channels of cerebral arteries. Using a device for intravital visualization of pial vessels, the reaction of arteries to the KATP-channel blocker glibenclamide (GB), the activator of the same channels of pinacidil (PI), acetylcholine (ACh), and ACh against a background of GB action (ACh/GB) 14 and 21 days after I/R and intravenous hMSC transplantation performed 7 days after ischemic exposure. On exposure to GB 14 days after I/R, 1.5–1.8 times fewer arteries narrowed than in the sham–operated (SO) rats. By day 21 after I/R, the constriction reaction was completely restored, except for arteries with a diameter more 40 μm. In the cell–therapy group, the constrictor response to GB was completely recovered to the level of SO animals in arteries with a diameter less than 40 μm by 14 day after I/R exposure; in arteries with a diameter of more than 40 μm, the constriction reaction did not recover until 21 days. The number of dilations per ACh/GB compared to a clear ACh in SO rats was reduced in 1.6–1.8 times on 14 day after I/R and in 1.6–6.6 after 21 days. In I/R animals on 14 day, the number of dilatations per ACh/GB compared to clear ACh was significantly increased in arteries with a diameter of more than 20 μm by 1.5–1.7 times, and after 21 days in arteries with a diameter of more than 40 μm by 1.2 times. After the introduction of hMSC, GB blocked ACh–mediated dilation in arteries less than 40 μm in diameter both on days 14 and 21 after I/R. In arteries with a diameter of more than 40 μm the functional activity of KATP-channels did not recover until 21 days. Conclusion. I/R of the rat cerebral cortex reduces the contribution of KATP-channels to maintaining the basal tone of the pial arteries and almost completely excludes these channels from the formation of ACh–mediated dilation during 21 days of the postischemic period. Practically did not participate in the dilatory response. Intravenous transplantation of hMSC, performed 7 days after I/R, results in restoration of participation of SMC KATP-channels in maintaining the basal tone and ACh–mediated dilatation of pial arteries with a diameter less than 40 μm already 14 days after I/R.
Effect of Heparin on the Formation and Healing of Gastric Ulcers Induced by Acetic Acid Application on the Gastric Mucosa in Rats
Authors: Efimov A. L. , Sakhno D. S. , Sigua B. V. , Yarushkina N. I. , Filaretova L. P. 
Published: April 2024

The key factor in maintaining the integrity of the gastric mucosa is its normal blood supply, respectively, the use of drugs that improve it, including through a positive effect on the rheological properties of blood, is in demand for the treatment of gastric ulcer. These drugs include the anticoagulant heparin. The aim of the work is to study the effect of heparin on the formation and healing of gastric ulcers induced by the application of 60% acetic acid to the gastric mucosa in rats, while assessing the possible risk of bleeding. After application of acetic acid (day 0), the area of gastric ulcers was assessed on the 4th day (formation of the ulcers) and the 7th day (healing of the ulcers). To assess the effect on ulcer formation, heparin (1000 IU/kg/day, subcutaneously) was administered from days 0 to 3, and on the healing from days 4 to 6 after acid application. To check for possible bleeding under the influence of heparin, the level of hemoglobin in the blood was tested before acid application (basal), on the 4th and 7th days after application. The degree of bleeding was assessed based on the relative decrease in hemoglobin levels. The administration of heparin led to a decrease in the average area of ulcers both on the 4th and on the 7th day compared with that in control rats (heparin vehicle). In control rats, both on the 4th and on the 7th day, the hemoglobin level was reduced compared to the corresponding basal level. Heparin had no effect on the hemoglobin level at day 4, but potentiated the decrease in mean hemoglobin level at day 7, increasing the number of animals having a greater relative decrease in hemoglobin level compared to the corresponding control group. Thus, heparin may have a gastroprotective effect, manifested both in the weakening of the formation of an ulcer and in the acceleration of its healing, however, there is a risk of bleeding when the ulcer heals.
Neutralization Dialysis of Phenylalanine and Mineral Salt Mixed Solution: Effect of Concentration and Flow Rate of Acid and Alkali Solutions
Authors: Porozhnyy M. V. , Gil V. V. , Kozmai A. E. 
Published: April 2024

Amino acids that are ampholytes can be effectively separated and purified by the method of neutralization dialysis (ND), whose advantage is the ability to control the pH value of the solution without adding reagents. An important task is to optimize the parameters of the ND process to ensure minimal losses of amino acids during their isolation from mixed solutions. An experimental study of the process of demineralization of the phenylalanine and sodium chloride equimolar mixture by the ND method was carried out. It is established that varying the concentration and flow rate of acid and alkali solutions in the corresponding compartments of the dialysis cell allows for regulating the pH value of the solution being desalted and controlling the amount of amino acid loss. Halving the acid concentration (from 0.10 to 0.05 M) allowed reducing the losses of phenylalanine from 18.3 to 16.4%, and using a lower solution flow rate in the acid compartment (0.75 instead of 1.50 cm s–1) made it possible to reduce these losses to 14.2%. At the same time, in all experiments, the electrical conductivity of the desalted solution decreased by 90%, which suggests a high degree of demineralization and the effectiveness of the method used to isolate phenylalanine from the mixed solution.
Gas Transport Properties of Vinylidene Fluoride-Tetrafluoroethylene Copolymers
Authors: Alentiev A. Yu. , Nikiforov R. Yu. , Levin I. S. , Tsarev D. A. , Ryzhikh V. E. , Syrtsova D. A. , Belov N. A. 
Published: April 2024

The influence of the content of tetrafluoroethylene (TFE) groups on the gas transport properties of vinylidene fluoride (VDF) and tetrafluoroethylene copolymers has been studied. Experimental values of the permeability coefficients P and diffusion coefficients D for gases H2, He, N2, O2, CO2, as well as lower hydrocarbons CH4, C2H4 and C2H6 were measured and their solubility coefficients S were calculated. The values of the solubility coefficients of CO2 and C2H4 were found to deviate from the linear correlation of lg S on the Lennard-Jones potential. An explanation of this effect was proposed based on facilitated transport models. It was demonstrated that an increase in the content of TFE groups leads to a significant increase in the permeability coefficients of the penetrants studied mainly due to an increase in their diffusion coefficients. So, the permeability coefficient of helium and hydrogen increases approximately in 2.5 times, for carbon dioxide in 3 times, for argon, oxygen, methane and ethylene in 3.5 times, and for nitrogen and ethane in 4.4 times, respectively. These gas separation parameters in combination with good film-forming properties and commercial availability allows us to consider the studied VDF-TFE copolymers as promising materials for the fabrication of composite gas separation membranes.
Correlation Between HbA1c and Body Mass Index Among Patients with High Lipid Profile Attending Johns Hopkins Aramco Healthcare Hospital in Saudi Arabia
Authors: Kheir Omer , Dossary Sheikha , Dhalaan Mohammad , AlHajri Salman , Aljeshi Ali , Wali Dawoud Raseel , Ghamdi Mohammad 
Published: April 2024

BACKGROUND: Dyslipidemia is a modifiable risk factor for cardiovascular diseases, diabetes, and stroke. Obesity and elevated HbA1c levels are both risk factors for cardiovascular diseases.

OBJECTIVES: The main objective of this study was to examine the relationship between HbA1C and body mass index among patients with high lipid profiles.

METHODS: This retrospective, hospital-based study was conducted at Johns Hopkins Aramco Healthcare Facilities. Data were extracted from medical health records and included demographics, lipid profiles, and HbA1c measurements. The study included 2368 non-diabetic participants, and DATAtab was used to analyze the data.

RESULTS: The participants were 57.05% male and 78.42% Saudi. The mean age was 41.48±12.1 years, and the mean body mass index was 28.44±5.53. There was a statistically significant relationship between the use of lipid lowering medicine and HbA1c (P<0.001). There was a very weak positive but statistically significant relationship between HbA1c and body mass index (r = 0.18, P<0.001). HbA1c and systolic blood pressure appeared to have a statistically significant positive association (r = 0.16, P< 0.001). There was no correlation between HbA1c and low-density lipoprotein cholesterol, total cholesterol, or diastolic blood pressure. There was an inverse correlation between HbA1c and high-density lipoprotein cholesterol (r = -0.11, P< 0.001). Regression was performed using a linear multivariable analysis with HbA1c as the dependent variable and age (B 0.192, P<0.001), body mass index (B 0.119, P<0.001), high-density lipoprotein cholesterol (B -0.058, P<0.005), triglyceride (B 0.093, P<0.001), lipid-lowering medication (B 0.104, P<0.001), and systolic blood pressure (B 0.060, P< 0.003) as independent variables.

CONCLUSION: The results indicated that HbA1c is linked to body mass index, age, systolic blood pressure, triglycerides, and high-density lipoprotein cholesterol levels. There was no correlation between HbA1c and low-density lipoprotein cholesterol, total cholesterol, or diastolic blood pressure.
PERSEPSI DAN SIKAP REMAJA TENTANG SEKS PRANIKAH DENGAN KEJADIAN KEHAMILAN PRANIKAH DI KELURAHAN RUMBALIBUNGA KOTA TIDORE KEPULAUAN TAHUN 2017
Authors: Suaib Nurkila 
Published: April 2024

Latar Belakang : Berdasarkan data World Health Organization (WHO) Tahun 2010, sekitar 16 jutaperempuan berusia 15-19 tahun melahirkan setiap tahunnya, sekitar 11% dari semua kelahiran di seluruh dunia. Wanita yang hamil pada usia 15-19 tahun mempunyai risiko yang lebih besar untuk mengalami komplikasi kehamilan dan persalinan dibandingkan wanita yang hamil pada usia 20-24 tahun (Aera, 2012). Tujuan Penelitian :Mengetahui Hubungan persepsi dan sikap remaja tentang seks pranikah dengan kejadian kehamilan Pranikah di Kel. Rumbalibunga Tahun 2017. MetodePenelitian : Penelitian ini merupakan jenis penelitian Observasional dengan rancangan penelitianCross sectional. Hasil Penelitian: Menunjukkan adanya hubungan yang sangat positif antara Persepsidan Sikap Remaja dengan Kehamilan Pranikah di Kelurahan Rumbalibunga dengan menunjukkan nilai signifikansi 0.001 atau lebih kecil 0.05. Kesimpulan: Terdapat Hubungan Persepsi dan Sikap Remaja tentang Seks Pranikah dengan Kehamilan Pranikah di Kelurahan Rumbalibunga Kota Tidore Kepulauan.
Hukum Lingkungan: Implementasi Peraturan Daerah tentang Pengelolaan Sampah Perkotaan di Kota Makassar
Authors: Irawan Arry , Patawari  
Published: April 2024

Abstract-This study aims to examine the urgency of applying environmental law in waste management and its impact on environmental protection, public health, and the achievement of sustainable development goals. This research method uses a qualitative approach. The data collection stage is done through interviews, observations, and document reviews. Observation of this research was carried out by direct observation at the location of the Final Disposal Site (TPA) in Makassar City and the surrounding urban environment. The document review is needed to collect data in the form of reports or information related to the implementation of local regulation number 4 of 2011 concerning Waste Management in Makassar City. The documents include regional regulation number 4 of 2011 concerning waste management in Makassar City, data on the amount of waste entering Antang Landfill, and evaluation data related to waste management in Makassar City. After the data has been collected, the process of processing and analyzing the research data is carried out. The data was analyzed by utilizing the Nvivo 12 Plus tool. The main finding of this research is that the application of environmental law in waste management is urgent because it is directly related to maintaining a clean and healthy environment, although the effort has been implemented, but it is still considered to need optimization. Environmental law plays a central role in regulating waste management practices that are safe, environmentally friendly, and in accordance with established standards. The main recommendations of this study are the need to strengthen the application of environmental law in waste management, increase public understanding of the importance of sustainable waste management practices, and promote green technology innovation in waste management to achieve sustainable development goals.

Keywords-: Environmental law; regulation; local regulation; waste
Gamificação inclusiva: crianças atípicas e o desenvolvimento de habilidades sociais
Authors: Ana Paula da Silva  , Roseneide Maria Batista Cirino  
Published: April 2024

Este artigo é parte da pesquisa de mestrado que se encontra em andamento e aborda a interação e comunicação de crianças com Transtorno do Espectro Autista em contextos inclusivos, propondo o uso da gamificação para auxiliar no desenvolvimento dessas habilidades e fortalecer práticas inclusivas. Surge da observação de lacunas nas práticas educacionais atuais em relação ao aprimoramento das habilidades de comunicação e interação em estudantes com Transtorno do Espectro Autista. Tem como objetivo avaliar como as práticas pedagógicas, com o suporte da gamificação, podem influenciar no desenvolvimento da comunicação e interação em crianças com Transtorno do Espectro Autista. A pesquisa se baseia na teoria Histórico-Cultural, com referências em Vygotsky, e em autores que defendem o uso de metodologias ativas, como Busarello, Baich e Moran. A metodologia adotada consiste em pesquisa bibliográfica e de campo como método de coleta de dados e aplicou-se experimento didático. O estudo está em desenvolvimento sendo aplicado em uma escola do município de Umuarama-PR. Os participantes são alunos com transtorno que estudam entre 1º ao 5º do ensino fundamental e que apresentam barreiras nas habilidades de comunicação e interação. Os dados produzidos inicialmente indicam, na análise comparativa, que dentre as propostas em prosa e gamificadas os estudantes respondem mais assertivamente, àquelas gamificadas.
Coronary artery lesions in children with Kawasaki disease: status quo and nursing care
Authors: Chen Cen , Chen Qiuhui , Zhang Tong , Ling Yanping 
Published: April 2024

AimCoronary artery lesion (CAL) is a common yet serious complication in children with Kawasaki disease. The aim of the present study was to evaluate the influencing factors of CAL in children with Kawasaki disease, to provide reference for the clinical treatment and care of children with Kawasaki disease.DesignA retrospective cohort study.MethodsChildren with Kawasaki disease treated in a tertiary hospital in China between 1 January 2021 and 31 December 2022 were selected. The characteristics and clinical data of children with Kawasaki disease were analyzed. Spearman’s correlation analysis was conducted to evaluate the relationship between CAL and the characteristics of children with Kawasaki disease. A logistic regression analysis was used to analyze the influencing factors of CAL in children with Kawasaki disease.ResultsIn total, 185 children with Kawasaki disease were included; the incidence of CAL in children with Kawasaki disease was 18.38%. Pearson’s correlation analysis showed that gender (r = 0.504), age (r = 0.611), duration of fever ≥10 days (r = 0.579), hemoglobin (Hb) (r = 0.623), and C-reactive protein (CRP) (r = 0.558) were all correlated with the CAL in children with Kawasaki disease (allp &lt; 0.05). Logistic regression analyses showed that male [odds ratio (OR) = 2.543, 95% confidence interval (CI): 1.801–3.077,p = 0.040], age ≤2 years (OR = 3.002, 95% CI: 2.744–3.641,p = 0.012), duration of fever ≥10 days (OR = 2.089, 95% CI: 1.624–2.515,p = 0.028), Hb ≤105 g/L (OR = 1.914, 95% CI: 1.431–2.406,p = 0.013), and CRP ≥100 mg/L (OR = 2.168, 95% CI: 1.893–2.531,p = 0.035) were the risk factors of CAL in children with Kawasaki disease (allp &lt; 0.05).ConclusionsThe incidence of CAL in children with Kawasaki disease is high and there are many related risk factors. Clinical medical workers should take early warning and carry out interventions and nursing care according to these risk factors to improve the prognosis of children with Kawasaki disease.
Inflammatory cytokines may mediate the causal relationship between gut microbiota and male infertility: a bidirectional, mediating, multivariate Mendelian randomization study
Authors: Zou Haoxi , Xu Ningning , Xu Huanying , Xing Xiaoyan , Chen Yanfen , Wu Suzhen 
Published: April 2024

IntroductionStudies have shown that the gut microbiota is associated with male infertility (MI). However, their causal relationship and potential mediators need more evidence to prove. We aimed to investigate the causal relationship between the gut microbiome and MI and the potential mediating role of inflammatory cytokines from a genetic perspective through a Mendelian randomization approach.MethodsThis study used data from genome-wide association studies of gut microbes (Mibiogen, n = 18, 340), inflammatory cytokines (NFBC1966, FYPCRS, FINRISK 1997 and 2002, n=13, 365), and male infertility (Finngen, n=120, 706) to perform two-way Mendelian randomization (MR), mediated MR, and multivariate MR(MVMR) analyses. In this study, the inverse variance weighting method was used as the primary analysis method, and other methods were used as supplementary analysis methods.ResultsIn the present study, two gut microbes and two inflammatory cytokines were found to have a potential causal relationship with MI. Of the two gut microorganisms causally associated with male infertility, Anaerotruncus increased the risk of male infertility (odds ratio = 1.81, 95% confidence interval = 1.18-2.77, P = 0.0062), and Bacteroides decreased the risk of male infertility (odds ratio = 0.57, 95% confidence interval = 0.33-0.96, P = 0.0363). In addition, of the two inflammatory cytokines identified, hepatocyte growth factor(HGF) reduced the risk of male infertility (odds ratio = 0.50, 95% confidence interval = 0.35-0.71, P = 0.0001), Monocyte chemotactic protein 3 (MCP-3) increased the risk of male infertility (odds ratio = 1.28, 95% confidence interval = 1.03-1.61, P = 0.0039). Mediated MR analysis showed that HGF mediated the causal effect of Bacteroides on MI (mediated percentage 38.9%). Multivariate MR analyses suggest that HGF may be one of the pathways through which Bacteroides affects MI, with other unexplored pathways.ConclusionThe present study suggests a causal relationship between specific gut microbiota, inflammatory cytokines, and MI. In addition, HGF may mediate the relationship between Bacteroides and MI.