bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immersive language learning: evaluating augmented reality filter for ESL speaking fluency teaching
Authors: Mohd Nabil Nor Sanak , Nordin Hasniza , Ab Rahman Faizahani 
Published: June 2024

PurposeThis study aims to explore how the integration of augmented reality (AR) filters into English as a second language (ESL) can enhance speaking fluency teaching. The study sheds light on how AR filter can be best implemented in speaking fluency teaching by the innovative opportunities to transform language learning experiences. In this study, ESL teachers' perceptions and experiences with AR filters in speaking fluency instructions were examined through qualitative research method.Design/methodology/approachThis study is an evaluation stage study within a bigger study which utilized design and developmental research (DDR) approach. In this third phase of DDR which is the evaluation phase, this study involved semi-structured interviews with six ESL teachers from six different public secondary school settings. Thematic analysis was conducted on the interview transcripts.FindingsData analysis revealed several key findings regarding the utilization of AR filters in ESL speaking fluency teaching. Firstly, participants reported that AR filters can be best used in various educational settings. Secondly, AR filters were found to provide supports for various students’ levels. Thirdly, participants identified that AR filters can be best used to cater students with diverse learning styles.Research limitations/implicationsThe work aims to help ESL educators in using AR filters in their speaking fluency teaching. The limitation of this study is that it includes only the experience of teachers from a public secondary school setting without taking into consideration other secondary institutions such as ESL teachers from private schools or boarding schools. The generalizability of our findings may be affected due to our reliance on self-reported data from a small sample size.Practical implicationsThe implications of these findings for ESL pedagogy and teacher professional development are discussed. By incorporating AR filters into ESL speaking fluency instruction, educators can create speaking fluency teaching in various settings such as formal and informal settings. Furthermore, ESL teachers may immerse students in environments that cater to the diverse language learners' styles and language levels through the use of AR filter. Overall, this research contributes to a deeper understanding of the potential of AR filters to transform ESL teaching and learning practices, paving the way for future innovations in language education.Originality/valueAvailable studies exploring AR in English teaching exist, but very limited of those utilized markerless AR, in the form of AR filters with speaking fluency teaching. Also, this paper focused on teachers’ experience with AR filters in contrast to students’ experience in public secondary school settings.
Navigating brand purpose in the post-pandemic era: insights from marketing agencies on supporting SDGs through strategic delineation and execution
Authors: Feri Alessandro , Ind Nicholas Jonathan , Tjandra Nathalia Christiani 
Published: June 2024

Purpose
This study aims to investigate the role of marketing agencies in aligning brand purpose with the Sustainable Development Goals (SDGs) in the post-pandemic era. This study explores whether and how marketing agencies delineate and execute brand purpose in a way that supports sustainable consumption and marketing models.

Design/methodology/approach
Data were gathered from semi-structured interviews with 35 senior managers at UK-based marketing agencies. The interviews were recorded, transcribed and analysed using NVivo software for inductive coding.

Findings
The study reveals that brand purpose in the post-pandemic era is increasingly aligned with the SDGs. Marketing agencies play a pivotal role in this alignment, as they not only help to delineate and execute the brand purpose but also do so in a way that amplifies perceived authenticity in the eyes of the brand stakeholders.

Originality/value
This research underscores the significance of marketing agencies in delineating and executing brand purpose that aligns with the SDGs. It enriches the literature by illustrating how agency expertise contributes to the evolution of brand purpose, guiding businesses towards responsible marketing practices and consumption patterns that support a sustainable future.
Climate policy uncertainty and energy impacts on trade openness and foreign direct investment in the United States: Evidence from the RALS co‐integration test
Authors: Eweade Babatunde Sunday , Güngör Hasan 
Published: June 2024

AbstractClimate change is becoming an increasingly pressing global issue, and understanding how climate policy uncertainty affects trade openness and foreign direct investment is crucial. This study provides contemporary insights into this complex relationship, particularly in the context of the United States, which is a major player in global trade and investment. The study employed a monthly dataset spanning from January 1990M01 to December 2020M12. Co‐integration exists between all the variables specified by employing Residual Augmented Least Squares (RALS‐EG), climate policy uncertainty, and fossil fuel consumption adverse influence upon trade openness and foreign direct investment, economic growth, and renewable energy consumption positive impact upon trade openness and foreign direct investment via the use of fully modified ordinary least square (FMOLS), and Dynamic Ordinary Least Squares (DOLS). The Fourier Toda‐Yamamoto causality reveals that climate policy uncertainty, economic growth, renewable energy, and trade openness exhibit bidirectional causality, while fossil fuels exhibit unidirectional causality. Based on the findings, policymakers should prioritize reducing climate policy uncertainty to create a more stable environment for trade and foreign direct investment (FDI). Clear and consistent climate policies can mitigate the negative impact of uncertainty on trade openness and FDI.
Combined analysis of metabolomics and 16S rRNA sequencing for ankylosing spondylitis patients before and after secukinumab therapy
Authors: Sun Chao , Chao Yuyan , Xu Haojie , Yang Xinmeng , Pei Lijia , Xu Guixia , Wang Fei , Fan Xiaoyun , Tang Lin , Xie Changhao , Su Yin , Wang Xin 
Published: June 2024

AbstractObjectiveAlterations in gut microbiota have been implicated in the pathogenesis of ankylosing spondylitis (AS), but the underlying mechanisms remain elusive. This study aims to investigate changes in gut microbiota and metabolites in individuals with AS before and after treatment with secukinumab, to identify the biological characteristics specific to AS patients and investigate the potential biomarkers, for optimizing therapeutic strategies more effectively.MethodsFecal microbiome data were collected from 30 AS patients before and after secukinumab therapy and compared with data from 40 healthy controls (HC). Additionally, we analyzed the metabolic profile of both groups from plasma.ResultsFindings indicated that the treatment‐induced changes in the composition of several crucial bacterial groups, including Megamonas, Prevotella_9, Faecalibacterium, Roseburia, Bacteroides, and Agathobacter. Post‐treatment, these groups exhibited a distribution more akin to that of the healthy populations compared with their pretreatment status. We identified three gut microbial taxa, namely Prevotellaceae_bacterium_Marseille_P2831, Prevotella_buccae, and Elusimicrobiota, as potential biomarkers for diagnosing individuals at a higher risk of developing AS and assessing disease outcomes. Plasma metabolomics analysis revealed 479 distinct metabolites and highlighted three disrupted metabolic pathways. Integration of microbiome and metabolomics datasets demonstrated a significant degree of correlation, underscoring the impact of the microbiome on metabolic activity.ConclusionSecukinumab can restore the balance of the gut microbiome and metabolites in AS patients, rendering them more similar to those found in the healthy population. The analysis of microbiome and metabolomics data have unveiled some candidate biomarkers capable of evaluating treatment efficacy.
Efficacy and safety of intrathecal diamorphine: a systematic review and meta‐analysis with meta‐regression and trial sequential analysis
Authors: Grape Sina , El‐Boghdadly Kariem , Jaques Cecile , Albrecht Eric 
Published: June 2024

SummaryBackgroundIntrathecal diamorphine is believed to provide postoperative analgesia but is associated with adverse effects such as nausea and vomiting. There is little evidence of synthesis regarding intrathecal diamorphine in the contemporary literature. We performed a systematic review, meta‐analysis with meta‐regression and trial sequential analysis to determine the magnitude of intrathecal diamorphine efficacy and safety.MethodsWe systematically searched the literature for trials comparing intrathecal diamorphine with a control group in patients undergoing all types of surgery. The primary efficacy and safety outcomes were intravenous morphine consumption and incidence of postoperative nausea and vomiting at 24 h following surgery, respectively.ResultsTwelve trials were identified, which included data for 712 patients. Intrathecal doses of diamorphine ranged from 100 μg to 2500 μg. Intravenous morphine consumption at 24 h postoperatively was significantly reduced in the intrathecal diamorphine group, with a mean difference (95%CI) of ‐8 mg (‐11 to ‐6), I2 = 93%, p < 0.001. There was a significant difference between three intrathecal diamorphine dosing subgroups but without correlation: mean differences (95%CI) ‐1 mg (‐3–0), ‐26 mg (‐40 to ‐11) and ‐6 mg (‐15–4) in patients receiving doses of 0–200 μg, 201–400 μg and > 400 μg, respectively (p = 0.003). Intrathecal diamorphine increased postoperative nausea and vomiting with a risk ratio (95%CI) of 1.37 (1.19–1.58), I2 = 7%, p < 0.001. There were no differences in postoperative nausea and vomiting between the three intrathecal diamorphine dosing subgroups. There was no correlation observed with meta‐regression of the primary efficacy and safety outcomes. The quality of evidence for all outcomes was very low.ConclusionThere is very low level of evidence that intrathecal diamorphine provides effective analgesia after surgery, while increasing postoperative nausea and vomiting with doses > 200 μg.
Laparoscopic Warshaw procedure in pediatric solid pseudopapillary neoplasm of the pancreas: Technical feasibility and oncological outcomes
Authors: Murata Yasuhiro , Tsuji Naoya , Noguchi Daisuke , Ito Takahiro , Hayasaki Aoi , Iizawa Yusuke , Fujii Takehiro , Tanemura Akihiro , Kuriyama Naohisa , Kishiwada Masashi , Mizuno Shugo 
Published: June 2024

AbstractAchieving margin‐negative resection is crucial in treatment of solid pseudopapillary neoplasm (SPN) of the pancreas, while preserving the spleen during distal pancreatectomy is highly desirable in pediatric cases. Laparoscopic Warshaw procedure (Lap‐WT) is invaluable when tumor involvement in splenic vessels complicates preservation. However, the feasibility of Lap‐WT in pediatric patients remains contentious. This study presents the clinical outcomes of three pediatric SPN cases who underwent Lap‐WT. The median age was 10 years, with a median tumor size of 50 mm. Lap‐WT demonstrated successful outcomes with a median operation time of 311 min and blood loss of 12 mL. No postoperative complications occurred, with a median length of hospital stay of 8 days. Long‐term follow‐up showed mild thrombocytopenia and increased spleen volume in two cases, perigastric varices in one, with no bleeding complications. No instances of tumor recurrence were observed. Lap‐WT emerges as a feasible approach for pediatric SPN, ensuring spleen preservation without compromising oncological outcomes.
Who feels happier right now?: The impact of temporal distance on children's judgements of emotional intensity
Authors: O'Brien Bronwyn , Ebeid Mohamed , Atance Cristina M. 
Published: June 2024

AbstractDo children consider temporal distance in their reasoning about the world? Using a novel method that relied minimally on verbal ability, we asked N = 106 3‐ to 6‐year‐olds to judge which of two characters felt more ‘happy’/‘sad’ right now: one engaging in a pleasant/unpleasant activity tomorrow or another engaging in this same activity when they are a year older. That is, we examined whether children understood that the closer in time a future event, the more intense the currently felt emotion. Starting at age 4, children correctly judged which child was more ‘happy’/‘sad’ right now. However, 4‐ to 6‐year‐olds tended not to explain their judgements by referring to temporal distance, per se. Results suggest that children are sensitive to temporal distance early in development, but do not yet verbally express this understanding. Implications for theories about children's future thinking and future areas of research are discussed.
Delta opioid receptor expression correlates to skin ageing and melanin expression in Asian women
Authors: Bigliardi Paul L. , Lo Sydney , Bigliardi Elena , Dancik Yuri , Leblanc‐Noblesse Emmanuelle , Bigliardi‐Qi Mei 
Published: June 2024

AbstractWhile the evidence for the implication of opioid receptors (OPr) in ageing is growing, there is, to our knowledge, no study focusing directly on changes in vivo cutaneous OPr expression with increasing age. We thus investigated OPr expression in 30 healthy female Asian volunteers in Southern China whose ages range from the early 20s to the early 60s. Excisional biopsies were taken from the sun‐exposed extensor area of the lower arm and the photo‐protected area of the upper inner arm. The thickness of the epidermal layers, melanin content, as well as expression of mu‐opioid receptors (MOPr) and delta‐opioid receptors (DOPr) were compared between different age ranges and photo‐exposure status. Significant increased epidermal hypertrophy on the extensor surface was observed. There was significant reduction of DOPr in the epidermis with increasing age, independent of photo‐ageing. The increase of melanin was significantly correlated with epidermal DOPr expression, not with MOPr expression. DOPr expression could thus serve as a marker for real biological ageing unaffected by chronic photo‐exposure. Additionally, DOPr expression was inversely correlated with the deposition of melanin. Based on these results, we hypothesise that regulation of DOPr expression could be used to improve aged skin, including hyperpigmentation.
The Geoeconomics of the Single Market for Financial Services
Authors: Quaglia Lucia , Verdun Amy 
Published: June 2024

AbstractWe discuss the geoeconomics of the Single Market in financial services in the European Union (EU). We examine three case studies that concern the EU and other major jurisdictions and that range from incipient geoeconomic use to outward weaponisation of the Single Market in finance. These cases are (1) the post‐2008 crisis transatlantic tug of war, whereby the EU leveraged its Single Market vis‐à‐vis the United States, seeking to set the rules for global finance; (2) the Brexit negotiations, when the EU acted as a bloc against the United Kingdom and successfully safeguarded the integrity of the Single Market; and (3) the fulsome war in Ukraine, during which the EU ‘weaponised’ its Single Market through the adoption of financial sanctions against Russia. We argue that a combination of external and internal factors accounts for this pattern: the evolution of the international economic and political system, in particular, the increasing challenges to the liberal international order, and intra‐EU developments, namely, the EU's ability to deploy its Single Market geoeconomically.
Designing the Food and Lifestyle Information Program (FLIP) culinary nutrition intervention for adults with mild‐to‐moderate intellectual disability
Authors: Asher Roberta C. , Shrewsbury Vanessa A. , Innes Beth , Fitzpatrick Arron , Simmonds Sarah , Collins Clare E. 
Published: June 2024

AbstractBackgroundPeople with intellectual disability have diverse needs and experience higher rates of diet‐related chronic disease such as type 2 diabetes compared to people without disability. However, they are infrequently included in development and implementation of interventions to address diet‐related chronic disease. The present study describes the process to plan, develop and refine the Food and Lifestyle Information Program (FLIP) culinary nutrition intervention for adults with mild‐to‐moderate intellectual disability.MethodsThe project was initiated by a disability service provider and was guided by the Cook‐Ed™ model and inclusive research principles. Initially the disability service provider and academic research team members co‐designed pre‐program consultation and pilot studies, and draft program resources. Pre‐program consultation explored paid disability support worker (n = 10) perceptions of cooking and food skills, nutrition priorities and optimal program format, which guided further program drafting. Program resources and pilot study design were further developed and refined with co‐researchers with lived experience of intellectual disability who attended a pre‐pilot and then pilot study sessions as remunerated co‐facilitators.ResultsKey characteristics of the FLIP intervention arising from pre‐program consultation included providing cooking task instruction in small steps, enabling participant choice in program activities, promoting an inclusive and social atmosphere, and providing paper‐based resources.ConclusionsFLIP intervention co‐design was enabled through ongoing input from the disability service provider and people with lived experience of intellectual disability. Evaluation of FLIP feasibility, acceptability and preliminary effectiveness to improve diet‐related health is underway.
MYB2 and MYB108 regulate lateral root development by interacting with LBD29 in Arabidopsis thaliana
Authors: Zhang Feng , Wang Junxia , Ding Tingting , Lin Xuefeng , Hu Haiying , Ding Zhaojun , Tian Huiyu 
Published: June 2024

ABSTRACTAUXIN RESPONSE FACTOR 7 (ARF7)‐mediated auxin signaling plays a key role in lateral root (LR) development by regulating downstream LATERAL ORGAN BOUNDARIES DOMAIN (LBD) transcription factor genes, including LBD16, LBD18, and LBD29. LBD proteins are believed to regulate the transcription of downstream genes as homodimers or heterodimers. However, whether LBD29 forms dimers with other proteins to regulate LR development remains unknown. Here, we determined that the Arabidopsis thaliana (L.) Heynh. MYB transcription factors MYB2 and MYB108 interact with LBD29 and regulate auxin‐induced LR development. Both MYB2 and MYB108 were induced by auxin in an ARF7‐dependent manner. Disruption of MYB2 by fusion with an SRDX domain severely affected auxin‐induced LR formation and the ability of LBD29 to induce LR development. By contrast, overexpression of MYB2 or MYB108 resulted in greater LR numbers, except in the lbd29 mutant background. These findings underscore the interdependence and importance of MYB2, MYB108, and LBD29 in regulating LR development. In addition, MYB2–LBD29 and MYB108–LBD29 complexes promoted the expression of CUTICLE DESTRUCTING FACTOR 1 (CDEF1), a member of the GDSL (Gly‐Asp‐Ser‐Leu) lipase/esterase family involved in LR development. In summary, this study identified MYB2–LBD29 and MYB108–LBD29 regulatory modules that act downstream of ARF7 and intricately control auxin‐mediated LR development.
Strength of relationship between body mass index and gross motor capacity in youth with intellectual disabilities
Authors: Pitetti K. , Bertapelli F. , Miller R. A. , Loovis M. , do Amaral‐Junior W. D. , de Barros‐Filho M. M. , Guerra‐Junior G. 
Published: June 2024

AbstractBackgroundAdequate skill levels of gross motor capacity affect activities of daily living, participation in recreational activities and general physical activity levels of youths (7–21 years). Most studies of typically developing youths have reported significant negative relationships between gross motor capacity and body mass index. The latter findings are especially of concern for youths with intellectual disabilities in that it has been estimated that 61% of children and 66% of adolescents were classified as overweight/obese. Therefore, the purpose of this study was to determine the strength of the relationship between body mass index and gross motor capacity among youths with mild to moderate intellectual disability (ID).MethodsComponents of the Bruininks–Oseretsky Test of Motor Proficiency (BOT‐2) were used for designated aspects of gross motor capacity: six items for upper limb coordination (ULC); seven items for balance (BAL); six items for bilateral coordination (BLC); and one item for agility (A‐2). Participants consisted of 654 youths (438 men), ages 8–21 years with ID. Participants were divided into pre‐puberty and post‐puberty men (post ≥12 years) and women (post ≥10 years of age). Body mass index (BMI, kg/m2) was determined by height and weight measurements on the day of testing. A Kendall's tau correlation coefficient (τ) was used to determine the strength of the relationship between body mass index and gross motor capacity (BOT‐2 test scores).ResultsThe τ values for both pre‐puberty and post‐puberty for all BAL, BLC, A‐2 tests and for three of the six ULC tests were negligible to very weak (τ = 0 to ±0.19). Higher τ values were seen for pre‐puberty youths in three of the ULC tests, but they fell within the weak range (τ < 0.24). When combining all pre‐puberty and post‐puberty participants, τ values were in the negligible to very weak range for all tests.ConclusionThe strength of relationship between body mass index and gross motor capacity as measured by the BOT‐2 subtest item scores used in this study is very weak and suggests that they are not clinically relevant.