bluuebunny/crossref_metadata_2025_split huggingface dataset:
Daily-Mean Temperature Reconstructed for Kansas from Early Instrumental and Modern Observations
Authors: Burnette Dorian J. , Stahle David W. , Mock Cary J. 
Published: October 2009

Abstract
A continuous record of 65 987 daily-mean temperature observations since 1828 has been developed for Manhattan, Kansas, by screening and correcting original station records of the U.S. Army Surgeon General, the Smithsonian Institution, and the Signal Service. Hourly, minimum, and maximum temperature observations from seven discontinuous historical stations and four modern stations in Kansas, Missouri, and Oklahoma were used to compile this unbroken record of daily-mean temperature. The historical temperature data were linked with the modern temperature record for Manhattan after these data were adjusted for time of observation differences, station movements, and changes in the environment around the station. The new daily-mean temperature reconstruction for Manhattan now extends with confidence back to 1 July 1855 and with more uncertainty back to 1 July 1828. The uncertainty prior to 1855 is due to instrumentation changes in 1843 and changes in observation practices in 1855 that occurred at many stations. The error estimates reported in this paper do not reflect these potential inhomogeneities and should be considered lower limits. Nonetheless, this new daily record indicates significant warming in all seasons; in heating and cooling degree-days; in the warmest and coldest days of the year; in extremes above the 90th percentile and below the 10th percentile; in the frequency of winter cold waves and summer heat waves; and in the overall annual-mean temperature, which has warmed by 1.57° ± 0.23°C since 1855 (1.27° ± 0.23°C since 1829). The warm Dust Bowl event in the summer of the 1930s and cold winters of the 1870s and 1880s dominate the reconstruction and included some of the warmest and coldest daily extremes, respectively, of the last 154–180 yr. This new reconstruction is currently the longest unbroken daily corrected record in the Americas. These data indicate that the nineteenth century was fundamentally cooler than the twentieth and early twenty-first century.
Hydrodynamics of the Caribbean Low-Level Jet and Its Relationship to Precipitation
Authors: Cook Kerry H. , Vizy Edward K. 
Published: October 2009

Abstract
The easterly Caribbean low-level jet (CLLJ) is a prominent climate feature over the Intra-America Seas, and it is associated with much of the water vapor transport from the tropical Atlantic into the Caribbean Basin. In this study, the North American Regional Reanalysis (NARR) is analyzed to improve the understanding of the dynamics of the CLLJ and its relationship to regional rainfall variations.
Horizontal momentum balances are examined to understand how jet variations on both diurnal and seasonal time scales are controlled. The jet is geostrophic to the first order. Its previously documented semidiurnal cycle (with minima at about 0400 and 1600 LT) is caused by semidiurnal cycling of the meridional geopotential height gradient in association with changes in the westward extension of the North Atlantic subtropical high (NASH). A diurnal cycle is superimposed, associated with a meridional land–sea breeze (solenoidal circulation) onto the north coast of South America, so that the weakest jet velocities occur at 1600 LT. The CLLJ is present throughout the year, and it is known to vary in strength semiannually. Peak magnitudes in July are related to the seasonal cycle of the NASH, and a second maximum in February is caused by heating over northern South America. From May through September, zonal geopotential gradients associated with summer heating over Central America and Mexico induce meridional flow. The CLLJ splits into two branches, including a southerly branch that connects with the Great Plains low-level jet (GPLLJ) bringing moisture into the central United States. During the rest of the year, the flow remains essentially zonal across the Caribbean Basin and into the Pacific.
A strong (weak) CLLJ is associated with reduced (enhanced) rainfall over the Caribbean Sea throughout the year in the NARR. The relationship with precipitation over land depends on the season. Despite the fact that the southerly branch of the CLLJ feeds into the meridional GPLLJ in May through September, variations in the CLLJ strength during these months do not impact U.S. precipitation, because the CLLJ strength is varying in response to regional-scale forcing and not to changes in the large-scale circulation. During the cool season, there are statistically significant correlations between the CLLJ index and rainfall over the United States. When the CLLJ is strong, there is anomalous northward moisture transport across the Gulf of Mexico into the central United States and pronounced rainfall increases over Louisiana and Texas. A weak jet is associated with anomalous westerly flow across the southern Caribbean region and significantly reduced rainfall over the south-central United States.
No connection between the intensity of the CLLJ and drought over the central United States is found. There are only three drought summers in the NARR period (1980, 1988, and 2006), and the CLLJ was extremely weak in 1988 but not in 1980 or 2006.
Analysis of Severe Rainstorm Characteristics of the Godavari Basin in Peninsular India
Authors: Kulkarni B. D. , Nandargi S. , Mulye S. S. 
Published: October 2009

AbstractThe analysis of rainstorms is of prime importance for the planning and design of water resources of any region. In the absence of actual records of streamflow data, analysis of rainstorms is useful for assessing flood potentialities as well as the runoff of river catchments. This study provides pertinent information on the spatial distribution characteristics of severe rainstorm events that occurred over the Godavari and its subbasins on the basis of 110 yr (1891–2000) of available rainfall data. The analysis showed that the August 1986 rainstorm had its areal extension over more than a 150 000 km2 area. It is also seen that the August 1913 rainstorm was the most efficient rainstorm over the basin. The rain depth data of severe rainstorms given in this paper can provide a reliable set of information to assess water resource planning on a probability basis. The relationship between the point to areal rainfall and area of the rainstorms from 1- to 3-day durations is also determined.
Southern Ocean Thermocline Ventilation
Authors: Sallée Jean-Baptiste , Speer Kevin , Rintoul Steve , Wijffels S. 
Published: October 2009

AbstractAn approximate mass (volume) budget in the surface layer of the Southern Ocean is used to investigate the intensity and regional variability of the ventilation process, discussed here in terms of subduction and upwelling. Ventilation resulting from Ekman pumping is estimated from satellite winds, the geostrophic mean component is assessed from a climatology strengthened with Argo data, and the eddy-induced advection is included via the parameterization of Gent and McWilliams, together with eddy mixing estimates. All three components contribute significantly to ventilation. Finally, the seasonal cycle of the upper ocean is resolved using Argo data.The circumpolar-averaged circulation shows an upwelling in the Antarctic Intermediate Water (AAIW) density classes, which is carried north into a zone of dense Subantarctic Mode Water (SAMW) subduction. Although no consistent net production is found in the light SAMW density classes, a large subduction of Subtropical Mode Water (STMW) is observed. The STMW area is fed by convergence of a southward and a northward residual meridional circulation. The eddy-induced contribution is important for the water mass transport in the vicinity of the Antartic Circumpolar Current. It balances the horizontal northward Ekman transport as well as the vertical Ekman pumping.While the circumpolar-averaged upper cell structure is consistent with the average surface fluxes, it hides strong longitudinal regional variations and does not represent any local regime. Subduction shows strong regional variability with bathymetrically constrained hotspots of large subduction. These hotspots are consistent with the interior potential vorticity structure and circulation in the thermocline. Pools of SAMW and AAIW of different densities are found along the circumpolar belt in association with the regional pattern of subduction and interior circulation.
Vertical Water Velocities from Underwater Gliders
Authors: Merckelbach Lucas , Smeed David , Griffiths Gwyn 
Published: October 2009

Abstract
The underwater glider is set to become an important platform for oceanographers to gather data within oceans. Gliders are usually equipped with a conductivity–temperature–depth (CTD) sensor, but a wide range of other sensors have been fitted to gliders.
In the present work, the authors aim at measuring the vertical water velocity. The vertical water velocity is obtained by subtracting the vertical glider velocity relative to the water from the vertical glider velocity relative to the water surface. The latter is obtained from the pressure sensor. For the former, a quasi-static model of planar glider flight is developed. The model requires three calibration parameters, the (parasite) drag coefficient, glider volume (at atmospheric pressure), and hull compressibility, which are found by minimizing a cost function based on the variance of the calculated vertical water velocity.
Vertical water velocities have been calculated from data gathered in the northwestern Mediterranean during the Gulf of Lions experiment, winter 2008. Although no direct comparison could be made with water velocities from an independent measurement technique, the authors show that, for two different heat loss regimes (≈0 and ≈400 W m−2), the calculated vertical velocity scales are comparable with those expected for internal waves and active open ocean convection, respectively. High noise levels resulting from the pressure sensor require the water velocity time series to be low-pass filtered with a cutoff period of 80 s. The absolute accuracy of the vertical water velocity is estimated at ±4 mm s−1.
The Influence of COX-2 Single Nucleotide Polymorphisms on Abdominal Aortic Aneurysm Development and the Associated Inflammation
Authors: Badger Stephen A. , Soong Chee V. , Young Ian S. , McGinty Ann , Mercer Caroline , Hughes Anneq E. 
Published: October 2009

IntroductionCyclooxygenase (COX)-2 influences cardiovascular disease and serum concentration of high-sensitivity C-reactive protein (hsCRP). The study purpose was to determine the influence of single nucleotide polymorphisms (SNPs) of the COX-2 gene on abdominal aortic aneurysm (AAA) development and serum hsCRP concentrations.Patients and MethodsPatients with AAA and disease-free controls were recruited. High-sensitivity C-reactive protein was measured by an enzyme-linked immunosorbent assay (ELISA) test. The distributions of COX-2 SNPs were investigated (rs20417 and rs4648307). The influence of the COX-2 SNPs on the hsCRP serum concentration was assessed.ResultsA total of 230 patients with AAA and 279 controls were included. No difference was found in the genotype distribution of the COX-2 SNPs rs20417 ( P = .26) and rs4648307 ( P = .90). They did not influence the hsCRP concentration ( P = .24 and P = .61, respectively). Haplotype analysis of COX-2 SNPs revealed no difference.ConclusionThese COX-2 SNPs do not play any role in AAA development and do not influence serum hsCRP. These results differentiate AAA development from atherosclerotic diseases.
Shallow Medial Tibial Plateau and Steep Medial and Lateral Tibial Slopes: New Risk Factors for Anterior Cruciate Ligament Injuries
Authors: Hashemi Javad , Chandrashekar Naveen , Mansouri Hossein , Gill Brian , Slauterbeck James R. , Schutt Robert C. , Dabezies Eugene , Beynnon Bruce D. 
Published: October 2009

BackgroundThe geometry of the tibial plateau has been largely ignored as a source of possible risk factors for anterior cruciate ligament injury. Discovering the anterior cruciate ligament injury risk factors associated with the tibial plateau may lead to delineation of the existing sex-based disparity in anterior cruciate ligament injuries and help develop strategies for the prevention of anterior cruciate ligament injuries regardless of gender.HypothesisIndividuals with a shallower medial tibial depth of concavity, while having increased posteriorly directed slope of their tibial plateau, are at increased risk of suffering an anterior cruciate ligament injury compared with those with decreased posterior slope and increased medial tibial depth. Furthermore, these relationships are different between men and women.Study DesignCase-control study (prevalence); Level of evidence, 3.MethodsThe medial, lateral, and coronal tibial plateau slopes as well as the medial tibial depth of concavity in 55 uninjured controls (33 women and 22 men) and 49 anterior cruciate ligament—injured cases (27 women and 22 men) were measured using magnetic resonance images. First, a preliminary t test was performed to establish any existing differences between groups. Next, a logistic regression model was developed to determine the probability of anterior cruciate ligament injury in an individual based on the measured covariates.ResultsThe female anterior cruciate ligament—injured cases had increased lateral tibial slope (P = .03) and shallower medial tibial depth (P = .0003) compared with the uninjured controls, while male cases had increased lateral and medial tibial slope (P = .02) and shallower medial tibial depth (P = .0004) compared with controls. The logistic regression analysis and odds ratio estimates showed that medial tibial depth is an important risk factor (odds ratio = 3.03 per 1 mm decrease in its value), followed by lateral tibial slope (odds ratio = 1.17 per 1° increase in its value) in all participants. The medial tibial slope (odds ratio = 1.18 per 1° increase in its value) was a risk factor only in men.ConclusionA combination of increased posterior-directed tibial plateau slope and shallow medial tibial plateau depth could be a major risk factor in anterior cruciate ligament injury susceptibility regardless of gender. Different injury risk models may be needed for men and women as other key risk factors are identified.
Zonal Chondrocyte Subpopulations Reacquire Zone-Specific Characteristics during in Vitro Redifferentiation
Authors: Schuurman Wouter , Gawlitta Debby , Klein Travis J. , ten Hoope Werner , van Rijen Mattie H. P. , Dhert Wouter J. A. , van Weeren P. René , Malda Jos 
Published: October 2009

Background If chondrocytes from the superficial, middle, and deep zones of articular cartilage could maintain or regain their characteristic properties during in vitro culture, it would be feasible to create constructs comprising these distinctive zones. Hypothesis Zone-specific characteristics of zonal cell populations will disappear during 2-dimensional expansion but will reappear after 3-dimensional redifferentiation, independent of the culture technique used (alginate beads versus pellet culture). Study Design Controlled laboratory study. Methods Equine articular chondrocytes from the 3 zones were expanded in monolayer culture (8 donors) and subsequently redifferentiated in pellet and alginate bead cultures for up to 4 weeks. Glycosaminoglycans and DNA were quantified, along with immunohistochemical assessment of the expression of various zonal markers, including cartilage oligomeric protein (marking cells from the deeper zones) and clusterin (specifically expressed by superficial chondrocytes). Results Cell yield varied between zones, but proliferation rates did not show significant differences. Expression of all evaluated zonal markers was lost during expansion. Compared to the alginate bead cultures, pellet cultures showed a higher amount of glycosaminoglycans produced per DNA after redifferentiation. In contrast to cells in pellet cultures, cells in alginate beads regained zonal differences, as evidenced by zone-specific reappearance of cartilage oligomeric protein and clusterin, as well as significantly higher glycosaminoglycans production by cells from the deep zone compared to the superficial zone. Conclusion Chondrocytes isolated from the 3 zones of equine cartilage can restore their zone-specific matrix expression when cultured in alginate after in vitro expansion. Clinical Relevance Appreciation of the zonal differences can lead to important advances in cartilage tissue engineering. Findings support the use of hydrogels such as alginate for engineering zonal cartilage constructs.
Acute Hemodynamic Effects of Recruitment Maneuvers in Patients With Acute Respiratory Distress Syndrome
Authors: Kwang Joo Park  , Yoon Jung Oh  , Hyuk Jae Chang  , Seung Soo Sheen  , Choi Junghyun , Keu Sung Lee  , Joo Hun Park  , Sung Chul Hwang  
Published: October 2009

Background: The recruitment maneuver (RM) in acute respiratory distress syndrome (ARDS) can cause hemodynamic derangement. We evaluated circulatory and cardiac changes during RMs. Methods: We performed sustained inflation (SI) with a pressure of 40 cm H2O for 30 seconds as an RM on 22 patients with ARDS. Blood pressure (BP) and heart rate were recorded immediately before, every 10 seconds during, and 30 seconds after the RM. Ventricular dimensions were obtained simultaneously using M-mode echocardiography, and tissue Doppler imaging was performed on the left ventricular wall. Results: Mean, systolic, and diastolic BP decreased at 20 and 30 seconds during 30-second RMs (mean BP: 92 ± 12 at baseline to 83 ± 18 mm Hg at the end of the RM, P < .05) and subsequently recovered. Heart rate decreased at 10 and 20 seconds during the RM, and tended to increase afterward. Both ventricular dimensions decreased significantly during the RM. The left ventricular ejection fraction and peak velocity of the left ventricle during systole remained stable. The fractional changes in mean BP and left ventricular end-diastolic dimension during the RMs were correlated significantly with each other (rs = 0.59). Static compliance of the respiratory system (Crs) was lower in patients with mean BP change ≥15% than in patients in whom the change was <15% (P < .05). Conclusions: A transient decrease in mean BP was observed during the RM, and its degree was correlated with the preload decrease, while cardiac contractility was maintained.
Developing a High-Performance Computing/Numerical Analysis Roadmap
Authors: Trefethen Anne , Higham Nick , Duff Iain , Coveney Peter 
Published: October 2009

A roadmap activity in the UK has leveraged US and European efforts for identifying the challenges and barriers in the development of high-performance computing (HPC) algorithms and software. The activity has identified the Grand Challenge to provide: 1. Algorithms and software that application developers can reuse in the form of high-quality, high performance, sustained software components, libraries and modules 2. A community environment that allows the sharing of software, communication of interdisciplinary knowledge and the development of appropriate skills. Through a series of workshops and discussions with UK HPC application groups and numerical analysts, five areas of challenge have emerged.
The mouse mutation “thrombocytopenia and cardiomyopathy” (trac) disrupts Abcg5: a spontaneous single gene model for human hereditary phytosterolemia/sitosterolemia
Authors: Chase Thomas H. , Lyons Bonnie L. , Bronson Roderick T. , Foreman Oded , Donahue Leah Rae , Burzenski Lisa M. , Gott Bruce , Lane Priscilla , Harris Belinda , Ceglarek Uta , Thiery Joachim , Wittenburg Henning , Thon Jonathan N. , Italiano Joseph E. , Johnson Kenneth R. , Shultz Leonard D. 
Published: October 2009

AbstractThe spontaneous mouse mutation “thrombocytopenia and cardiomyopathy” (trac) causes macrothrombocytopenia, prolonged bleeding times, anemia, leukopenia, infertility, cardiomyopathy, and shortened life span. Homozygotes show a 20-fold decrease in platelet numbers and a 3-fold increase in platelet size with structural alterations and functional impairments in activation and aggregation. Megakaryocytes in trac/trac mice are present in increased numbers, have poorly developed demarcation membrane systems, and have decreased polyploidy. The thrombocytopenia is not intrinsic to defects at the level of hematopoietic progenitor cells but is associated with a microenvironmental abnormality. The trac mutation maps to mouse chromosome 17, syntenic with human chromosome 2p21-22. A G to A mutation in exon 10 of the adenosine triphosphate (ATP)–binding cassette subfamily G, member 5 (Abcg5) gene, alters a tryptophan codon (UGG) to a premature stop codon (UAG). Crosses with mice doubly transgenic for the human ABCG5 and ABCG8 genes rescued platelet counts and volumes. ABCG5 and ABCG8 form a functional complex that limits dietary phytosterol accumulation. Phytosterolemia in trac/trac mice confirmed a functional defect in the ABCG5/ABCG8 transport system. The trac mutation provides a new clinically significant animal model for human phytosterolemia and provides a new means for studying the role of phytosterols in hematologic diseases and testing therapeutic interventions.
AML1/RUNX1 point mutation possibly promotes leukemic transformation in myeloproliferative neoplasms
Authors: Ding Ye , Harada Yuka , Imagawa Jun , Kimura Akiro , Harada Hironori 
Published: October 2009

Abstract
Myeloproliferative neoplasms (MPNs) are clonal hematopoietic stem cell disorders characterized by proliferation of one or more myeloid cell lineages. Some patients exhibit leukemic transformation (LT) by unknown mechanisms, and chemotherapy may increase the risk of LT. To clarify the molecular mechanisms of LT, gene alterations involved in LT from patients in the chronic phase (CP) of MPNs were identified. Among 18 patients who progressed to leukemia, AML1/RUNX1 mutations were detected in 5 patients at the LT but in none at the CP. To investigate the leukemogenic effect of AML1/RUNX1 mutants, the AML1D171N mutant was transduced into CD34+ cells from patients in the CP of MPNs. The D171N transduction resulted in proliferation of immature myeloid cells, enhanced self-renewal capacity, and proliferation of primitive progenitors. Taken together, these results indicate that AML1/RUNX1 point mutations may have a leukemogenic potential in MPN stem cells, and they may promote leukemic transformation in MPN.
International consensus report on the investigation and management of primary immune thrombocytopenia
Authors: Provan Drew , Stasi Roberto , Newland Adrian C. , Blanchette Victor S. , Bolton-Maggs Paula , Bussel James B. , Chong Beng H. , Cines Douglas B. , Gernsheimer Terry B. , Godeau Bertrand , Grainger John , Greer Ian , Hunt Beverley J. , Imbach Paul A. , Lyons Gordon , McMillan Robert , Rodeghiero Francesco , Sanz Miguel A. , Tarantino Michael , Watson Shirley , Young Joan , Kuter David J. 
Published: October 2009

AbstractPreviously published guidelines for the diagnosis and management of primary immune thrombocytopenia (ITP) require updating largely due to the introduction of new classes of therapeutic agents, and a greater understanding of the disease pathophysiology. However, treatment-related decisions still remain principally dependent on clinical expertise or patient preference rather than high-quality clinical trial evidence. This consensus document aims to report on new data and provide consensus-based recommendations relating to diagnosis and treatment of ITP in adults, in children, and during pregnancy. The inclusion of summary tables within this document, supported by information tables in the online appendices, is intended to aid in clinical decision making.