bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognosis and influencing factors of ER-positive, HER2-low breast cancer patients with residual disease after neoadjuvant chemotherapy: a retrospective study
Authors: Tang Lingfeng , Jiang Linshan , Shu Xiujie , Jin Yudi , Yu Haochen , Liu Shengchun 
Published: May 2024

AbstractPreviously, we found that patients with estrogen receptor (ER)-positive, HER2-low breast cancer are resistant to neoadjuvant chemotherapy (NACT) and have worse outcomes than those who achieve pathological complete response (pCR) after NACT. This study aimed to investigate the prognosis and influencing factors in these patients. A total of 618 patients with ER-positive breast cancer who received standard thrice-weekly NACT were enrolled, including 411 patients with ER-positive, HER2-low breast cancer. Data on the clinicopathological features of these patients before and after NACT were collected. Univariate and multivariate Cox regression analyses were used to identify the independent factors affecting 5-year disease-free survival (DFS). Among the ER-positive, HER2-low patients, 49 (11.9%) achieved a pCR after NACT. A significant difference in survival was observed between patients with and without residual disease after NACT. Additionally, changes in immunohistochemical markers and tumor stages before and after NACT were found to be significant. According to univariate and multivariate analyses, cN_stage (P = 0.002), ER (P = 0.002) and Ki67 (P = 0.023) expression before NACT were significantly associated with 5-year DFS, while pT_stage (P = 0.015), pN_stage (P = 0.029), ER (P = 0.020) and Ki67 (P < 0.001) levels after NACT were related to 5-year DFS in ER-positive, HER2-low patients with residual disease. Our study suggested that high proliferation, low ER expression and advanced stage before and after NACT are associated with a poor prognosis, providing useful information for developing long-term treatment strategies for ER-positive, HER2-low breast cancer in patients with residual disease in the future.
The manatee variational autoencoder model for predicting gene expression alterations caused by transcription factor perturbations
Authors: Yang Ying , Seninge Lucas , Wang Ziyuan , Oro Anthony , Stuart Joshua M. , Ding Hongxu 
Published: May 2024

AbstractWe present the Manatee variational autoencoder model to predict transcription factor (TF) perturbation-induced transcriptomes. We demonstrate that the Manatee in silico perturbation analysis recapitulates target transcriptomic phenotypes in diverse cellular lineage transitions. We further propose the Manatee in silico screening analysis for prioritizing TF combinations targeting desired transcriptomic phenotypes.
Evolution characteristics and multi-scenario prediction of habitat quality in Yulin City based on PLUS and InVEST models
Authors: Li Shifeng , Hong Zenglin , Xue Xuping , Zheng Xiaofeng , Du Shaoshao , Liu Xiaofeng 
Published: May 2024

AbstractAs a major energy city in China, Yulin City has faced huge challenges to the ecological environment with its rapid economic development and rapid urbanization. Therefore, it is of great significance to study the impact of land use changes on habitat quality. Based on three periods of land use data in Yulin City in 1995, 2005 and 2015, the PLUS model was used to simulate the land use changes in 2015. The measured kappa coefficient was 0.8859, which met the simulation accuracy requirements. By setting development zone boundaries and adjusting parameters, three progressive scenarios are designed to predict the spatial distribution of land use in Yulin City in 2035. The InVEST model was used to analyze the spatiotemporal evolution of Yulin City’s habitat quality in the past 20 years and evaluate the distribution of Yulin City’s habitat quality under three scenarios after 20 years. The results are as follows: (1) During the study period, construction land in Yulin City expanded rapidly, with an area increase of 380.87 km2 in 20 years, and ecological land gradually shrank. (2) The land use simulation results of Yulin City under various scenarios in 2035 show that future land use changes in Yulin City will mainly be concentrated in the central and western regions. (3) During the study period, the habitat quality of Yulin City was at a medium level and the overall habitat quality showed a downward trend. Spatially, the degree of habitat quality degradation in Yulin City showed a characteristic of gradually decreasing from West to East. (4) By 2035, under the scenario of suitable urban economic development, Yulin City’s habitat quality has been improved to a certain extent, which not only protects ecological security but also meets the demand for construction land for urban development. The results of this study help the government better understand the evolution of land use and habitat quality in Yulin City in the past 20 years, and provide theoretical support and reference for the formulation of Yulin City’s ecological environment protection policies and the implementation of ecological protection work under the current land spatial planning.
Optimizing hematite filter cake treatment using reducing agents
Authors: Siddig Osama , Elkatatny Salaheldin , Alafnan Saad 
Published: May 2024

AbstractIn drilling operations, the formation of a filter cake is crucial for well stability, but its removal post-drilling is essential to restore rock formation productivity. This study focuses on hematite-based filter cakes and investigates factors influencing their solubility and removal, addressing a significant knowledge gap in the field. The research methodology involves examining the effects of various factors, including types and concentrations of reducing agents, temperature, particle size, and treatment duration, on the dissolution process. Notably, Nuclear Magnetic Resonance (NMR) tests are employed to assess the treatment's impact on core porosity. Among the diverse reducing agents examined, ferrous chloride emerges as the optimal choice for effectively enhancing hematite solubility. Particularly, a composite solution of ferrous chloride (10 wt.%) and hydrochloric acid (6 wt.%), was highly efficient demonstrated by exhibiting rapid solubilization of hematite filter cakes. A removal efficiency of approximately 99%, with a parallel enhancement in core permeability was achieved. NMR tests reveal the treatment's success in reinstating the porosity system, which had undergone reduction due to drilling fluid particles. Crucially, the solution exhibits a considerably lower corrosion rate than concentrated hydrochloric acid, highlighting its potential to mitigate environmental concerns while ensuring efficient filter cake removal. The findings of this research provide valuable insights into optimizing post-drilling operations, balancing environmental sustainability and operational efficiency. The identified composite solution offers a promising approach to efficient filter cake removal while mitigating environmental concerns associated with corrosion. Overall, this study contributes to advancing the understanding and practice of well productivity enhancement in the oil and gas industry.
A molecular glue RBM39-degrader induces synthetic lethality in cancer cells with homologous recombination repair deficiency
Authors: Kohsaka Shinji , Yagishita Shigehiro , Shirai Yukina , Matsuno Yusuke , Ueno Toshihide , Kojima Shinya , Ikeuchi Hiroshi , Ikegami Masachika , Kitada Rina , Yoshioka Ken-ichi , Toshimitsu Kohta , Tabata Kimiyo , Yokoi Akira , Doi Toshihiko , Yamamoto Noboru , Owa Takashi , Hamada Akinobu , Mano Hiroyuki 
Published: May 2024

AbstractE7820 and Indisulam (E7070) are sulfonamide molecular glues that modulate RNA splicing by degrading the splicing factor RBM39 via ternary complex formation with the E3 ligase adaptor DCAF15. To identify biomarkers of the antitumor efficacy of E7820, we treated patient-derived xenograft (PDX) mouse models established from 42 patients with solid tumors. The overall response rate was 38.1% (16 PDXs), and tumor regression was observed across various tumor types. Exome sequencing of the PDX genome revealed that loss-of-function mutations in genes of the homologous recombination repair (HRR) system, such as ATM, were significantly enriched in tumors that responded to E7820 (p = 4.5 × 103). Interestingly, E7820-mediated double-strand breaks in DNA were increased in tumors with BRCA2 dysfunction, and knockdown of BRCA1/2 transcripts or knockout of ATM, ATR, or BAP1 sensitized cancer cells to E7820. Transcriptomic analyses revealed that E7820 treatment resulted in the intron retention of mRNAs and decreased transcription, especially for HRR genes. This induced HRR malfunction probably leads to the synthetic lethality of tumor cells with homologous recombination deficiency (HRD). Furthermore, E7820, in combination with olaparib, exerted a synergistic effect, and E7820 was even effective in an olaparib-resistant cell line. In conclusion, HRD is a promising predictive biomarker of E7820 efficacy and has a high potential to improve the prognosis of patients with HRD-positive cancers.
Pharmacological inhibition of the LIF/LIFR autocrine loop reveals vulnerability of ovarian cancer cells to ferroptosis
Authors: Ebrahimi Behnam , Viswanadhapalli Suryavathi , Pratap Uday P. , Rahul Gopalam , Yang Xue , Pitta Venkata Prabhakar , Drel Viktor , Santhamma Bindu , Konda Swapna , Li Xiaonan , Sanchez Alondra Lee Rodriguez , Yan Hui , Sareddy Gangadhara R. , Xu Zhenming , Singh Brij B. , Valente Philip T. , Chen Yidong , Lai Zhao , Rao Manjeet , Kost Edward R. , Curiel Tyler , Tekmal Rajeshwar R. , Nair Hareesh B. , Vadlamudi Ratna K. 
Published: May 2024

AbstractOf all gynecologic cancers, epithelial-ovarian cancer (OCa) stands out with the highest mortality rates. Despite all efforts, 90% of individuals who receive standard surgical and cytotoxic therapy experience disease recurrence. The precise mechanism by which leukemia inhibitory factor (LIF) and its receptor (LIFR) contribute to the progression of OCa remains unknown. Analysis of cancer databases revealed that elevated expression of LIF or LIFR was associated with poor progression-free survival of OCa patients and a predictor of poor response to chemotherapy. Using multiple primary and established OCa cell lines or tissues that represent five subtypes of epithelial-OCa, we demonstrated that LIF/LIFR autocrine signaling is active in OCa. Moreover, treatment with LIFR inhibitor, EC359 significantly reduced OCa cell viability and cell survival with an IC50 ranging from 5-50 nM. Furthermore, EC359 diminished the stemness of OCa cells. Mechanistic studies using RNA-seq and rescue experiments unveiled that EC359 primarily induced ferroptosis by suppressing the glutathione antioxidant defense system. Using multiple in vitro, ex vivo and in vivo models including cell-based xenografts, patient-derived explants, organoids, and xenograft tumors, we demonstrated that EC359 dramatically reduced the growth and progression of OCa. Additionally, EC359 therapy considerably improved tumor immunogenicity by robust CD45+ leukocyte tumor infiltration and polarizing tumor-associated macrophages (TAMs) toward M1 phenotype while showing no impact on normal T-, B-, and other immune cells. Collectively, our findings indicate that the LIF/LIFR autocrine loop plays an essential role in OCa progression and that EC359 could be a promising therapeutic agent for OCa.
A novel sparse recovery space‐time adaptive processing algorithm using the log‐sum penalty to approximate the ℓ0 − norm penalty
Authors: Liu Kun , Wang Tong 
Published: May 2024

AbstractApplying the sparse recovery (SR) technique to airborne radar space‐time adaptive processing (STAP) can greatly reduce the number of required training samples, which is advantageous in detecting targets in non‐homogeneous and non‐stationary clutter environments. However, the poor performance, the slow convergence speed or the high computational complexity of the traditional SR STAP algorithms limit their practical application. To tackle this problem, a novel efficient SR STAP algorithm is proposed. The newly proposed SR STAP algorithm utilises the log‐sum penalty to approximate the penalty, which exhibits improved convergence performance and clutter suppression performance compared to the traditional SR STAP algorithms. Besides, the proposed algorithm can ensure the convergence in each iteration by offering a closed‐form analytic solution. Furthermore, the result of the mathematical derivation demonstrates the essential equivalence between our method and the iterative reweighted method. By utilising this equivalence, two additional methods are proposed that incorporate the knowledge of the clutter Capon spectrum and the clutter spectrum of the iterative adaptive approach (IAA) as the components of weighted values, resulting in further performance improvement of the proposed algorithm. Finally, simulation results with both simulated data and Mountain‐Top data demonstrate the high effectiveness and performance of the proposed methods.
Analysis of electrical contact characteristics of strap contacts used in high voltage bushings under eccentric conditions
Authors: Wang Qingyu , Zhou Xiaoyu , Yang Wei , Hu Di , Jin Shoufeng , Xie Tao , Liu Peng , Peng Zongren 
Published: May 2024

AbstractThe contact finger electrical connection structure is a crucial component of high voltage bushings, and its safety and reliability directly impact the operational stability of the bushing. To investigate electrical contact performance of the contact finger under eccentric conditions, a three‐dimensional electrical, thermal, and force multi‐physics coupling calculation model was established. Additionally, a test platform was constructed to measure electrical contact characteristics of the contact finger. The contact characteristics of the contact finger when the male head was axially deflected and radially offset compared to the female head were obtained. The research findings indicate when the male head deflects axially, the contact force changes of the contact finger blades on both sides are opposite. Moreover, as the axial deflection angle of the male head increases, the resistance of the electrical connection structure shows a rising‐slow decreasing‐fluctuating trend. The resistance is highest at 3°, with a resistance increase rate of 7.35%. Furthermore, the resistance of the electrical connection structure varies with the radial offset of the male head, following a power function. Contact failure occurs when the radial offset is 1.31 mm, and the resistance increase rate reaches 24.9% at a radial offset of 1.58 mm.
Acute Appendicitis in Children with Hematological Malignancies: The Need for Early Diagnosis and Prompt Treatment—A Single-Center Case Series
Authors: Kakkar Shruti , Jain Arihant , Jain Evani , Gupta Anubhavv , Kaur Navneet , Jain Anirudh , Grewal Alka , Budhiraja Sushil , Kakkar Chandan 
Published: May 2024

Abstract
Introduction Appendicitis in patients with hematological malignancies presents with vague symptoms, thus requiring a high degree of suspicion for early diagnosis and treatment to prevent complications.
Objectives The aim of this article was to describe the demographic, clinicoradiological, operative findings, and outcomes in patients with acute appendicitis with underlying hematological malignancies.
Materials and Methods A retrospective review of pediatric patients with hematological malignancy who developed acute appendicitis was conducted. Medical records of patients were reviewed for patient demographics, disease status, signs, and symptoms at the time of diagnosis of acute appendicitis, and outcome. The laboratory, radiological, and histological findings were retrieved from the hospital records.
Results Six (2.4%) patients developed acute appendicitis over the past 8 years among a total of 254 patients treated for hematological malignancies in the unit. Five patients had underlying acute lymphoblastic leukemia (ALL) and one had acute myeloid leukemia (AML). Of the five patients, three were in postremission consolidation, one each in the delayed intensification and maintenance phase of chemotherapy. The child with AML was on induction chemotherapy for the first relapse at the time of diagnosis. Fever and abdominal pain were the common presenting symptoms. Diagnosis was made on ultrasound abdomen in five patients, and one patient was diagnosed on computed tomography. All patients underwent open appendectomy. Two patients had evidence of appendiceal perforation. Three patients had neutropenia at the time of developing appendicitis and underwent appendectomy regardless of the absolute neutrophil count (ANC). Five patients recovered well, and chemotherapy was restarted within 2 weeks of appendectomy. One patient developed a superficial surgical site infection. and one patient with relapsed AML expired due to refractory septic shock.
Conclusion Acute appendicitis in patients with hematological malignancies can present with subtle signs and symptoms. Appendectomy can be safely performed irrespective of the ANC.
A multi-criteria simulation of European coastal shipping routes in the ‘age of sail’
Authors: Litvine Alexis D. , Lewis Joseph , Starzec Arthur W. 
Published: May 2024

AbstractThis article introduces a new method to model sailing routes before the age of steam based on real-world sailing conditions. Using a broad range of historical meteorological data, it offers monthly routing predictions for historical shipping corridors and tests them against historical evidence. In this article the model was applied to French and British ports. The output reveals the presence of historical shipping corridors and offer the first journey-time metrics to and from all European ports.
How does narcissistic leadership influence change-oriented organizational citizenship behavior? Empirical evidence from China
Authors: Fang Yangchun , Liu Yonghua , Yu Peiling , Chen Nuo 
Published: May 2024

AbstractBased on conservation of resources theory and the work–home resources model, this study examines how and when narcissistic leadership influences employees’ change-oriented organizational citizenship behavior. A total of 363 employees from 61 teams across numerous enterprises based in central China were surveyed using a questionnaire. The study hypotheses were tested using structural equation modeling and Monte Carlo simulation analysis. The findings revealed that narcissistic leadership results in the development of a negative team climate, termed “team chaxu climate,” which, in turn, hinders employees’ change-oriented organizational citizenship behavior. Furthermore, this study explored the moderating role of leaders’ family affective support in the relationship between narcissistic leadership and team chaxu climate. This study contributes to our understanding of the relationship between narcissistic leadership and employee organizational citizenship behavior and empirically validates the work–home resources model.
What do we mean by British architecture?
Authors: Arnold Dana 
Published: May 2024

Abstract
This chapter introduces the key concepts of British architecture. It provides an overview with examples of what is understood by the term architect, and how this has been diversified. The different ways in which histories of British architecture have been written and approached influence the understanding of the field, including women’s involvement with architecture. Additionally, the National Heritage List for England presents another way in which historic architecture in Britain has been evaluated and recorded. The chapter explains that the social and cultural value of a building can assume equal significance to its architectural style or authorship when assessing its merit.
Testis-Specific Protein, Y-Encoded-Like 2 Activates JAK2/STAT3 Pathway in Hypothalamic Paraventricular Nucleus to Sustain Hypertension
Authors: Li Ying , Xu Yang-Fei , Chi Hong-Li , Yu Jia-Yue , Gao Ya-Nan , Li Hong-Bao , Kang Yu-Ming , Yu Xiao-Jing 
Published: May 2024

Abstract

BACKGROUND
In the hypothalamic paraventricular nucleus (PVN) of spontaneously hypertensive rats (SHRs), the expression of the testis-specific protein, Y-encoded-like 2 (TSPYL2) and the phosphorylation level of Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) are higher comparing with the normotensive Wistar Kyoto rats (WKY). But how they are involved in hypertension remains unclear. TSPYL2 may interact with JAK2/STAT3 in PVN to sustain high blood pressure during hypertension.

METHODS
Knockdown of TSPYL2 via adeno-associated virus (AAV) carrying shRNA was conducted through bilateral microinjection into the PVN of SHR and WKY rats. JAK2/STAT3 inhibition was achieved by intraperitoneally or PVN injection of AG490 into the SHRs. Blood pressure (BP), plasma norepinephrine (NE), PVN inflammatory response, and PVN oxidative stress were measured.

RESULTS
TSPYL2 knock-down in the PVN of SHRs but not WKYs led to reduced BP and plasma NE, deactivation of JAK2/STAT3, decreased expression of pro-inflammatory cytokine IL-1β, and increased expression of anti-inflammatory cytokine IL-10 in the PVN. Meanwhile, AG490 administrated in both ways reduced the BP in the SHRs and deactivated JAK2/STAT3 but failed to change the expression of TSPYL2 in PVN. AG490 also downregulated expression of IL-1β and upregulated expression of IL-10. Both knockdown of TSPYL2 and inhibition of JAK2/STAT3 can reduce the oxidative stress in the PVN of SHRs.

CONCLUSION
JAK2/STAT3 is regulated by TSPYL2 in the PVN of SHRs, and PVN TSPYL2/JAK2/STAT3 is essential for maintaining high BP in hypertensive rats, making it a potential therapeutic target for hypertension.
Plasmatic NT-proBNP is strongly associated with atrial fibrillation in patients with Implantable cardioverter defibrillator
Authors: Allgaier R , Strack C , Wallner S , Hubauer U , Lehn P , Luchner A , Maier L , Jungbauer C 
Published: May 2024

Abstract

Background and objectives
Atrial fibrillation is common in patients with chronic heart failure and associated with poor outcome in these patients. Plasmatic NT-proBNP represents the gold standard biomarker for chronic heart failure. Further, recent studies showed prognostic impact of urinary NT-proBNP. Aim of the study was to assess the association of plasmatic as well as urinary NT-proBNP and atrial fibrillation in a cohort of patients with implantable cardioverter defibrillator (ICD).

Methods
412 patients were included in the study. Fresh spot urine and blood samples were used to assess urinary as well as plasmatic NT-proBNP. Urinary NT-proBNP was normalized to urinary creatinine. Follow-up was performed after 45 months. Heart rhythm history was evaluated and a 12-lead electrocardiogram was performed at enrollment (sinus rhythm (SR, n = 306), atrial fibrillation (AFib, n = 79)).

Results
Patients suffering from atrial fibrillation showed significant higher age, reduced left ventricular ejection fraction (LVEF), higher rates of chronic kidney disease, hypertension and urinary as well as plasmatic NT-proBNP compared to patients with sinus rhythm (each p &lt; 0.05). There were no differences regarding Diabetes, primary prevention ICD indication, coronary artery disease and dilatative cardiomyopathy (each p = n.s.).
In ROC analysis, plasmatic NT-proBNP showed promising predictive values regarding AFib (AUC: 0.80, IQR 0.76-0.85, p &lt; 0.001) as well as urinary NT-proBNP (AUC: 0.76, IQR 0.71-0.81, p &lt; 0.001). There was no significant difference between plasmatic and urinary NT-proBNP according to ROC analysis (p = n.s.).
Plasmatic NT-proBNP was shown as a significant predictor regarding existence of atrial fibrillation in binary logistic regression analysis, beside age (p &lt; 0.05). Diabetes, hypertension, serum creatinine, LVEF, coronary artery disease and primary prevention ICD indication were no significant predictors (p = n.s.). Urinary NT-proBNP was not shown as a significant predictor regarding existence of atrial fibrillation in binary logistic regression analysis (p = n.s.).

Conclusion
Elevated levels of plasmatic NT-proBNP are strongly associated with the prevalence of atrial fibrillation in a cohort of ICD patients.