bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Concise Formal Synthesis of Porothramycins A and B via Zincke Pyridinium Ring‐Opening/Ring‐Closing Cascade.
Authors: Michels Theo D. , Kier Matthew J. , Kearney Aaron M. , Vanderwal Christopher D. 
Published: October 2010

AbstractThe Tbs‐protection of the hydroxy‐group prior to the rearrangement as a key step of the method is crucial as no dihydropyrrole product is obtained otherwise.
ChemInform Abstract: Isolation and Characterization of 23‐O‐Mycinosyl‐20‐dihydro‐rosamicin: A New Rosamicin Analogue Derived from Engineered Micromonospora rosaria.
Authors: Anzai Yojiro , Sakai Ayami , Li Wei , Iizaka Yohei , Koike Kazuo , Kinoshita Kenji , Kato Fumio 
Published: October 2010

AbstractThe title compound IZIII (I) is isolated from Micromonospora rosaria TPMA0001.
ChemInform Abstract: Aqabamycins A‐G: Novel Nitro Maleimides from a Marine Vibrio Species. Part 1. Taxonomy, Fermentation, Isolation and Biological Activities.
Authors: Al‐Zereini Wael , Fotso Fondja Yao Clarisse Blanchine , Laatsch Hartmut , Anke Heidrun 
Published: October 2010

AbstractSeven novel maleimide derivatives are isolated from the surface of the soft coral Sinularia polydactyla collected from the Red Sea.
ChemInform Abstract: Xanthoradone C, a New Potentiator of Imipenem Activity Against Methicillin‐Resistant Staphylococcus aureus, Produced by Penicillium radicum FKI‐3765‐2.
Authors: Yamazaki Hiroyuki , Omura Satoshi , Tomoda Hiroshi 
Published: October 2010

AbstractXanthoradone C (I) is isolated from Penicillium radicum FKI‐3765‐2 along with the known xanthoradones A and B.
ChemInform Abstract: Synthetic Strategies and Theoretical Investigations for Tuning the Structure of Silver Coordination Compounds and Their Applications
Authors: Slenters Tunde Vig , Sague Jorge L. , Brunetto Priscilla S. , Zuber Stefanie , Fleury Antoine , Mirolo Laurent , Robin Adeline Y. , Meuwly Markus , Gordon Oliver , Landmann Regine , et al. et al. 
Published: October 2010

AbstractReview: 34 refs.
ChemInform Abstract: The α/β‐Hydrolase Fold 3DM Database (ABHDB) as a Tool for Protein Engineering
Authors: Kourist Robert , Jochens Helge , Bartsch Sebastian , Kuipers Remko , Padhi Santosh Kumar , Gall Markus , Boettcher Dominique , Joosten Henk‐Jan , Bornscheuer Uwe T. 
Published: October 2010

AbstractReview: about 60 refs.
Fluoride Sensing by Catechol‐Based π‐Electron Systems
Authors: An Byeong‐Kwan , Wang Xin , Burn Paul L. , Meredith Paul 
Published: October 2010

AbstractWe have developed new catechol‐based sensors that can detect fluoride via fluorescence or optical absorption even in the presence of other halides. The level and sensitivity of detection of the sensing molecules is dependent on the chromophore length, which is controlled by the number of thiophene units (one to three) within the chromophore. The sensor with three thiophene units, (E)‐2‐(2,2′‐terthiophen‐5‐yl)‐3‐(3,4‐dihydroxyphenyl)acrylonitrile, gives the best response to fluoride. By using fluorescence measurements fluoride is detectable over the concentration range 1.7 μM to 200 μM. Importantly, when adsorbed onto a solid support the fluorescent catechol dye can be used to detect the presence of fluoride in aqueous solution.
Black Specks in Dialysis Fluid: An Unusual Case of Peritonitis in a Pediatric Patient on Peritoneal Dialysis
Authors: Charlton Jennifer R. , Barcia John P. , Norwood Victoria F. 
Published: October 2010

AbstractA 13‐year‐old boy resumed peritoneal dialysis after the loss of a deceased donor renal transplant but was main‐tained on mycophenolate mofetil and monthly infusions of intravenous immunoglobulin to reduce his panel reactive antibody level. He developed low‐grade fever, cloudy fluid, and abdominal pain without peritoneal signs. His mother reported seeing some black “flakes” in his effluent. He was admitted and treated for presumed bacterial peritonitis twice with neither bacterial nor fungal growth on cultures. He received empiric antibiotics and appeared to respond partially. The patient remained asymptomatic with little abdominal pain, but had progressive difficulties with drain‐age. A black “speck” was obtained and identified as Curvularia. The peritoneal dialysis catheter was removed, and he was treated with both intravenous and intraperitoneal amphotericin B. This is the second case of peritonitis caused by Curvularia in a pediatric peritoneal dialysis patient reported in the literature. peritonitis is a serious complication of peritoneal dialy‐Fungal sis. Filamentous species such as Curvularia are uncommon, with a total of 10 reported cases. Although it has been reported as a disseminated infection, it is rarely pathogenic in humans. Of the 10 reported cases, 7 reported the pres‐ence of black proteinaceous material in the lumen of the Tenckhoff catheter. The most important measure in the treatment of peritonitis caused by Curvularia is removal of the peritoneal dialysis catheter. Curvularia species have been found to be susceptible in vitro to many antifungals, but there is no standard for therapy. Black “specks” in dialysate effluent should raise the level of concern for fungal peritonitis. Dial. Transplant. © 2010 Wiley Periodicals, Inc.
The use of terlipressin in hepatorenal syndrome
Authors: Rozov‐Ung Inna , Panesar Mandip 
Published: October 2010

AbstractHepatorenal syndrome (HRS) is a potentially reversible cause of acute renal failure that occurs in patients with hepatic failure resulting from advanced cirrhosis. It is characterized by impaired kidney function in the setting of normal renal parenchyma, alterations in cardiovascular function, splanchnic vasodilation, and overactivity of the sympathetic nervous and the renin‐angiotensin systems causing severe arterial vasoconstriction. Clinically, patients will present with the classic signs and symptoms of liver and renal failure, such as ascites, jaundice, coagulopathy, hepatic encephalopathy, and decreased urine output. Patients with cirrhosis are thought to have extreme circulatory dysfunction caused by portal hypertension‐induced release of vasodilators (primarily nitric oxide) into the splanchnic circulation, causing local vasodilation. Terlipressin is a synthetic long‐acting analogue of vasopressin in which lysine is substituted for arginine at position 8 and the N‐triglycyl residue. It has been shown to cause direct vasoconstriction of the systemic arteriolar and splanchnic vasculature. It affects the V1 vasopressin receptors of systemic vasculature more strongly than the V2 vasopressin receptors of the kidneys. Although it is not currently approved by the U.S. Food and Drug Administration, it has been widely studied and is currently being used in other countries for the treatment of HRS. Terlipressin is quickly emerging as a promising treatment of hepatorenal syndrome. Today its best use may be in improving renal function in preparation for liver transplantation, which has shown to reduce post‐transplant morbidity and mortality.
Patient survival and the combination of vitamin D and phosphorus binder in dialysis
Authors: Konta Tsuneo , Hoshikawa Masato , Takasaki Satoshi , Ichikawa Kazunobu , Mashima Yusuke , Takahashi Toshiyuki , Abiko Hiroshi , Masakane Ikuto , Matsunaga Tomohito , Suzuki Masayuki , Degawa Noriyuki , Kubota Isao 
Published: October 2010

AbstractOBJECTIVETreatment with either vitamin D or phosphorus binder alone improves the survival of dialysis patients. This multicenter observational study investigated whether a combination of these drugs was related to prognosis in Japanese dialysis patients.METHODSMaintenance dialysis patients (n = 466) were registered in 2003 and followed for up to 5 years. Group survival according to their use of vitamin D and phosphorous binder were compared using Cox‐proportional hazard analysis.RESULTSDuring the follow‐up period, 132 deaths (63 cardiovascular and 69 non‐cardiovascular deaths) occurred. Compared with the patients who used vitamin D and phosphorus binder concomitantly (n = 269), all‐cause mortality was higher in patients using neither drug (n = 36, hazard ratio [HR] 3.53, 95% CI 1.39−8.94, p = 0.008), using phosphorus binder alone (n = 115, HR 2.16, 95% CI 1.19–3.90, p = 0.011), and using vitamin D alone (n = 46, HR 1.38, 95% CI 0.55−3.46, p = 0.496) after adjustment with possible confounders. The advantage for patients who used both drugs concomitantly was also significant in cardiovascular mortality, but not in non‐cardiovascular mortality.CONCLUSIONSThe combination of vitamin D and phosphorus binder was significantly related to survival in dialysis patients. Dial. Transplant. © 2010 Wiley Periodicals, Inc.
Unmeasured nitrogen losses in pediatric patients treated with peritoneal dialysis
Authors: Uemura Osamu , Nagai Takuhito , Yamakawa Satoshi , Ushijima Katsumi , Yamada Takuji , Hibi Yoshiko , Mimatsu Haruka , Yamasaki Yasuhito 
Published: October 2010

AbstractBACKGROUNDDue to their active growth, children require more protein intake than adults. We therefore hypoth‐esized that dialysis dosage should be greater in children than in adults to achieve an equivalent BUN level. We assessed unmeasured nitrogen losses to determine whether a higher dialysis dosage is required in pediatric than in adult peritoneal dialysis (PD) patients.METHODSWe examined urea kinetics 25 times in 13 pediatric patients divided into three age groups: <5 years, ≥5 and <10 years, and ≥10 years. Nutrient intake was calculated over 3 days, dietary protein intake (DPI) was aver‐aged, and protein equivalent of nitrogen appearance rates (PNA) were calculated. Anabolism by growth was added to the PNA to calculate the corrected PNA, and the corrected PNA/DPI was compared among the three age groups.RESULTSMedian corrected PNA/DPI differed significantly among the three age groups (p < 0.001), with a significant positive correlation between age and corrected PNA/DPI (p < 0.001). Unmeasured nitrogen losses were 43.7% in children aged 5 years, 27.9% in children ≥5 and <10 years, and 10.7% in children aged ≥10 years.CONCLUSIONSUnmeasured nitrogen losses should be considered when determining the delivered PD dose by Kt/Vurea in children, because these losses are greater in children with PD, especially in infants, than in adults. Therefore, it is not necessary for dialysis dosage to be greater in children than in adults, even when aiming for equal BUN concentrations.
(Carboxymethyl–Dextran)‐Modified Magnetic Nanoparticles Conjugated to Octreotide for MRI Applications
Authors: Han Guo‐Cheng , Ouyang Yang , Long Xue‐Ying , Zhou Yu , Li Meng , Liu You‐Nian , Kraatz Heinz‐Bernhard 
Published: October 2010

AbstractThe synthesis of (octreotide–carboxymethyl–dextran)‐modified magnetic nanoparticles (CMD‐MNPs), which were characterized by FT‐IR, AFM, TEM and XRD, and magnetic hysteresis, is described. Magnetic Resonance Imaging (MRI) experiments were performed on a 1.5 Tesla Magnetom Vision machine. The internalization of CMD‐MNPs‐OC into pancreatic cancer cells Bx‐PC3 and colon cancer cells HCT‐116 were investigated by transmission electron microscopy (TEM) and magnetic resonance imaging (MRI). The nanoparticles can be recognized specifically, via the somatostatin receptor, and which can be used as a T2 MRI contrast agent. TEM and MRI results show that somatostatin receptor can deliver OC‐modified MNPs into the cytoplasm of a cancer cell line.
Influence of natural antioxidants on the formation of trans‐fatty‐acid isomers during heat treatment of sunflower oil
Authors: Filip Sebastjan , Hribar Janez , Vidrih Rajko 
Published: October 2010

AbstractThe intake of foods containing trans fatty acids (TFAs) can have deleterious effects on human health, mainly on the cardiovascular system. Thus, it is important to consider the processes that form TFAs in foods, and the alternatives to minimise their formation. The influence of two added natural antioxidants on TFA formation during heat treatment (120 h at 180°C) of sunflower vegetable oil were examined: rosemary extract (Rosmarinus officinalis L.) (1 g per kg oil) and lutein (0.1 g per kg oil). Changes in FA composition were determined using Ag‐ion SPE and gas–liquid chromatography, with total polar compounds determined using dielectric constant measurements and the index of atherogenicity was calculated. Total TFAs with ≥1 trans double bond increased from 0.91 to 1.71% in control samples; this increase was significantly less with both rosemary extract (1.55%) and lutein (1.43%) additions. Among the individual TFAs, significant increases were seen for C18:1,t‐9, C18:2,t‐9,t‐12 and C18:2,c‐9,t‐12/9‐t,12‐c. Polar compounds also increased, with the highest concentrations in control samples, and significantly less with both rosemary extract and lutein additions. According to results of our study, we can summarize that addition of lutein have greater effect on reduction of TFA formation than rosemary extract.Practical applications: Antioxidants, particularly from plants, are widely used in the food industry. They can provide benefits in food preparation, including improving colour, odour and stability, acting as acid regulators and natural preservatives. They have also become accepted by customers and consumers, and so indirectly they have had effects on consumer perception. Addition of natural antioxidants such as rosemary extract is usually limited by the sensory characteristics of the food, with one study showing that addition of rosemary extract at 1–3 g per kg vegetable oil is recommended. The effects of antioxidants on the formation of TFAs in vegetable oils has not been well studied in the literature. Among the already known benefits, the use of such antioxidants as functional ingredients in lipid technologies might reduce the formation of TFAs during thermal treatment.
Cross‐metathesis of unsaturated triglycerides with methyl acrylate: Synthesis of a dimeric metathesis product
Authors: Biermann Ursula , Meier Michael A. R. , Butte Werner , Metzger Jürgen O. 
Published: October 2010

AbstractHighly functionalized dimeric triglycerides, such as compound 2, are obtained as minor products besides branched macromolecules from the acyclic triene metathesis (ATMET) polymerization of unsaturated triglycerides such as glyceryl triundec‐10‐enoate 1 and methyl acrylate (MA) in the presence of the second generation Hoveyda–Grubbs catalyst. The formed amount of interesting products of lower molecular weight during the ATMET reaction depends on the ratio of MA and triglyceride, reaction time, and temperature. We isolated the dimeric metathesis product 2 and synthesized the respective partially hydrogenated dimer 3 regioselectivly in a seven step reaction sequence starting from 10‐undecenoic acid 7 and glycerol. Product 3 was unambiguously characterized by 13C and 1H NMR and MS as well as the further intermediate products of the seven step reaction including 10,11 bromo‐undecanoic acid 8, the respective brominated 1,3‐diglyceride 9, the brominated 1,3‐triglyceride 6, and the self‐metathesis products 4 and 5 which were isolated and purified.
P‐Phenyl‐2,2,6,6‐tetramethylphosphorinan‐4‐ol: An Air‐Stable P,O‐Type Ligand for Palladium‐Mediated Cross‐Coupling Reactions
Authors: Ullah Ehsan , McNulty James , Larichev Vladimir , Robertson Al J. 
Published: October 2010

AbstractA two‐step entry to a chemically robust, hindered P,O‐type phosphorinane‐based ligand and its application toward Pd‐mediated cross‐coupling reactions of unactivated aryl chlorides is presented.
Low‐level laser therapy for protection against skeletal muscle damage after ischemia–reperfusion injury in rat hindlimbs
Authors: Lakyová Lucia , Toporcer Tomáš , Tomečková Vladimíra , Sabo Ján , Radoňak Jozef 
Published: October 2010

AbstractBackground and ObjectiveDespite numerous hypotheses regarding the action of laser light, the use of low‐level laser therapy (LLLT) in ischemic reperfusion (I/R) injury is still being verified. The present study investigates the effects of low‐level laser irradiation (LLLI) on I/R injury of the musculus gracilis in rats.Materials and MethodsI/R injury of the musculus gracilis flap was induced in male adult Sprague–Dawley rats (n = 84). Rats were subdivided depending on treatment into four subgroups: (1) healthy group, (2) I/R injury without irradiation, (3) R group irradiated only during reperfusion after injury, and (4) IR group irradiated during ischemia and reperfusion injury. LLLT (AlGaInP; λ = 670 nm; 4 J/cm2; 40 mW/cm2) was applied to the injured muscle four times daily until euthanasia.ResultsLactate dehydrogenase (LD) levels were significantly lower (P<0.05) in the irradiated groups during the first 12–120 hours, while the lower creatine kinase (CK) level reached statistical significance only at 24 hours in the irradiated group when compared to the control group. The number of polymorphonuclear leukocytes in the gracilis muscle was significantly lower in the treated group only on the second day (P<0.0001). The lowered percentage of necrosis in the muscle tissue was statistically significant after 6 and 10 days of treatment (P<0.0001), while lower atrophy and higher neovascularization were observed at 6–14 days of irradiation (P<0.05). There was no statistically significant difference between the group irradiated only during reperfusion and that irradiated during ischemia and reperfusion.ConclusionLLLT confers a protective effect against early inflammatory tissue response, further atrophy, and necrosis of the muscle and it stimulates neovascularization after I/R injury. Lasers Surg. Med. 42:825–832, 2010 © 2010 Wiley‐Liss, Inc.
Laser preconditioning on cranial bone site: Analysis of morphological vascular parameters
Authors: Desmons Sophie O. , Salleron Julia , Delfosse Caroline J. , Falgayrac Guillaume , Penel Guillaume , Mordon Serge R. 
Published: October 2010

AbstractBackground and ObjectivesBone vascularization is a key factor in the bone healing process following X‐ray irradiation. Preserving the vascular network from X‐ray‐induced injury is a relevant approach in the promotion of bone healing. Previously, we developed a protocol of laser preconditioning (810 nm diode laser, 36 J/cm2) prior to X‐ray radiation (18.75 Gy) which protects the bone vascular network from deleterious effects of X‐ray radiation. The aim of this present work is to characterize the effects of laser preconditioning on the bone through a morphological analysis of vascular parameters.Materials and MethodsDigital images of the vascular plexus were taken through an optical bone chamber which was implanted onto the calvaria of rabbits. Bespoke software was used for the quantification of the vessels (classified in four groups according to their diameter), vessel length, and number of nodes at weeks 0, 4, and 8. Twenty rabbits were divided into four groups: control group #1 (n = 5); laser group #2 (n = 5). X‐ray radiation group #3 (n = 5), laser preconditioning 24 hours prior to X‐ray radiation group #4 (n = 5).ResultsThe bone vascular network was stable for groups #1 and #2. Statistical analysis showed a significant reduction of each observed vascular parameter for groups #3 and #4. In the laser preconditioned group #4 the loss was less marked than in the X‐ray group #3, especially for large vessels (diameter >50 µm).Discussion and ConclusionWe provide in vivo microcirculatory evidence to support the concept of laser preconditioning of bone. A computer‐based semi‐automatic system is described to quantify superficial bone vascular network parameters that had been treated by laser preconditioning prior to X‐ray radiation. Laser preconditioning significantly attenuates the deletion of the superficial bone vascular network irradiated by X‐ray, especially concerning large diameter vessels. Lasers Surg. Med. 42:791–797, 2010 © 2010 Wiley‐Liss, Inc.
Treatment of leg veins with combined pulsed dye and Nd:YAG lasers: 60 patients assessed at 6 months
Authors: Trelles Mario A. , Weiss Robert , Moreno‐Moragas Javier , Romero Carmen , Vélez Mariano , Álvarez Xavier 
Published: October 2010

AbstractIntroductionLeg telangiectasias have been reported to have been treated with a variety of lasers. This study was designed to measure response to treatment of leg telangiectasias with a unique coupled 585 nm and 1064 nm pulse.MethodsSixty female patients (24–62 y.o., skin types II–IV) with leg vein varicosities were treated with pulses of a combined 585 nm long pulsed dye (LPDL) and 1064 nm Nd:YAG lasers, which were delivered sequentially using a novel dual laser device. Pulses were placed along the entire length of the targeted veins. A beam diameter of 7 mm with pulses of 10 ms and 9J/cm2 of fluence for LPDL, and pulses of 30 ms and 80 J/cm2 for the 106 nm Nd:YAG were utilized and these remained uniform. Time delays between sequential LPDL and Nd:YAG pulses were 125 ms, 250 ms and 500 ms depending on vein diameter of 4, 3 and 2 mm respectively. One or two treatments were given at 2 month intervals, with post‐treatment assessments at 6 months following the final treatment. Patients subjectively assessed the treatment and their results were used to draw up a satisfaction index (SI). Objective assessment was based on clinical photography and computer‐generated data using a vein clearance detection computer program.ResultsThe overall patient satisfaction rate was 47 of 60 patients and the objective assessments, based on blinded evaluation of clinical photography as well as computer assessment, demonstrated good to very good improvement in 47 by photograph evaluation and 49 of 60 patients by computer edge detection data.ConclusionsThe combination of LPDL and Nd:YAG laser pulses offered efficient treatment of leg veins irrespective of skin type. Results were better on blue and vessels larger than 1 mm. Side effects were minimal and transient. Lasers Surg. Med. 42:769–774, 2010 © 2010 Wiley‐Liss, Inc.
Fractional ablative carbon dioxide laser resurfacing for skin rejuvenation and acne scars in Asians
Authors: Chan Nicola P.Y. , Ho Stephanie G.Y. , Yeung Chi K. , Shek Samantha Y.N. , Chan Henry H. 
Published: October 2010

AbstractBackground and ObjectivesAblative fractional resurfacing (AFR) is a new modality for photorejuvenation and acne scars which combines carbon dioxide (CO2) laser ablation with fractional photothermolysis. The objective is to evaluate the efficacy and side effects of a new fractional CO2 ablative device (Fraxel Re:pair) for skin rejuvenation and acne scars in Asians.Materials and MethodsNine patients underwent one full‐face treatment. The energy levels ranged from 30–70 mJ with coverage between 30% and 45%. Improvement in skin texture, laxity, wrinkles, enlarged pores, overall pigmentation irregularity, and adverse effects were assessed up to 6 months post‐treatment. Standardized photographs using the Canfield Visia CR system® were assessed by two independent observers. Subjective improvement was assessed by patient questionnaires.ResultsNine Chinese patients (skin types III and IV, mean age 44.8) were included. Statistically significant improvements were seen for skin texture, skin laxity, wrinkles, enlarged pores, and acne scars. The post‐inflammatory hyperpigmentation rate was 55.5% and 11.1% at 1 and 6 months post‐treatment, respectively. Eighty‐six percent of patients were overall satisfied to very satisfied with the treatment.ConclusionAblative fractional CO2 laser resurfacing was overall safe and effective for skin rejuvenation and acne scars in Asians. However, in view of the high post‐inflammatory rate and the statistically significant but only mild to moderate improvement after a single treatment as observed in this study, there is a need to review the current role of fractional ablative CO2 laser treatment as compared to fractional non‐ablative for skin rejuvenation and acne scar treatment in Asians. Lasers Surg. Med. 42:775–783, 2010 © 2010 Wiley‐Liss, Inc.