bluuebunny/crossref_metadata_2025_split huggingface dataset:
Generalization of a Deep Learning Model for Continuous Glucose Monitoring–Based Hypoglycemia Prediction: Algorithm Development and Validation Study
Authors: Shao Jian , Pan Ying , Kou Wei-Bin , Feng Huyi , Zhao Yu , Zhou Kaixin , Zhong Shao 
Published: June 2024

Abstract

Background
Predicting hypoglycemia while maintaining a low false alarm rate is a challenge for the wide adoption of continuous glucose monitoring (CGM) devices in diabetes management. One small study suggested that a deep learning model based on the long short-term memory (LSTM) network had better performance in hypoglycemia prediction than traditional machine learning algorithms in European patients with type 1 diabetes. However, given that many well-recognized deep learning models perform poorly outside the training setting, it remains unclear whether the LSTM model could be generalized to different populations or patients with other diabetes subtypes.

Objective
The aim of this study was to validate LSTM hypoglycemia prediction models in more diverse populations and across a wide spectrum of patients with different subtypes of diabetes.

Methods
We assembled two large data sets of patients with type 1 and type 2 diabetes. The primary data set including CGM data from 192 Chinese patients with diabetes was used to develop the LSTM, support vector machine (SVM), and random forest (RF) models for hypoglycemia prediction with a prediction horizon of 30 minutes. Hypoglycemia was categorized into mild (glucose=54-70 mg/dL) and severe (glucose<54 mg/dL) levels. The validation data set of 427 patients of European-American ancestry in the United States was used to validate the models and examine their generalizations. The predictive performance of the models was evaluated according to the sensitivity, specificity, and area under the receiver operating characteristic curve (AUC).

Results
For the difficult-to-predict mild hypoglycemia events, the LSTM model consistently achieved AUC values greater than 97% in the primary data set, with a less than 3% AUC reduction in the validation data set, indicating that the model was robust and generalizable across populations. AUC values above 93% were also achieved when the LSTM model was applied to both type 1 and type 2 diabetes in the validation data set, further strengthening the generalizability of the model. Under different satisfactory levels of sensitivity for mild and severe hypoglycemia prediction, the LSTM model achieved higher specificity than the SVM and RF models, thereby reducing false alarms.

Conclusions
Our results demonstrate that the LSTM model is robust for hypoglycemia prediction and is generalizable across populations or diabetes subtypes. Given its additional advantage of false-alarm reduction, the LSTM model is a strong candidate to be widely implemented in future CGM devices for hypoglycemia prediction.
Implementation of Total Productive Maintenance (TPM) Using Overall Equipment Effectiveness (OEE) Method on HPLC Instruments in Laboratory
Authors: Jannahti Adik Bela , Lasmana Cecep , Fauzi Muchammad 
Published: June 2024

The study aimed to assess the efficacy of HPLC instruments in a pharmaceutical laboratory at PT. XYZ by evaluating three OEE matrices (availability, performance, and quality) and identifying the losses leading to low OEE scores affecting the chromatography process performance. The method used is quantitative to calculate the availability rate, performance rate, and quality ratio based on the breakdown data and quantity of product data, followed by calculating the OEE score and comparing the obtained OEE and the world-class standard OEE score. The results demonstrate that the average availability rate in 2022 is 90,73%, the performance rate is 90,45%, and the quality ratio is 95,55%, resulting in the OEE score of 78,42%, which does not meet the world-class OEE standards score. To identify the problems causing the low OEE score, a qualitative analysis is performed using Current Condition Analysis and Fish Bone Diagram. Research indicates that five factors contribute to low OEE scores for HPLC instruments in PT. XYZ, including Method, Man, Machine, Material, and Environment. For each factor, the proposed improvement is described to increase the OEE score, including establishing the maintenance procedure, a training program for laboratory personnel, inventory management for spare parts, and an operating procedure. Keywords: Total Productive Maintenance, Overall Equipment Effectiveness, HPLC, Fish Bone Diagram
Tren Penelitian Kesehatan Mental Mahasiswa: Analisis Bibliometrik
Authors: Hertinjung Wisnu Sri , Taufik Taufik , Purwandari Eny , Karyani Usmi 
Published: June 2024

Kesehatan mental mahasiswa menjadi tren penelitian dalam tiga tahun terakhir. Perlu pemahaman yang komprehensif mengenai masalah kesehatan mental mahasiswa agar dapat diambil tindak lanjut yang tepat untuk mengatasinya. Tujuan analisis bibliometrik ini mengeksplorasi literatur akademis tentang kesehatan mental pada mahasiswa. Data dikumpulkan melalui basis data Scopus untuk artikel yang terbit pada tahun 2018-2023, dengan kata kunci “mental health” AND “college student”. Diperoleh hasil akhir sebanyak 1024 dari 1091 dokumen yang dianalisis secara bibliometric menggunakan perangkat lunak Mendeley, Publish or Perish (PoP), dan VOSviewer. Hasil menunjukkan pada 3 tahun terakhir, tren penelitian kesehatan mental mahasiswa mengalami peningkatan hingga 300% dari penelitian di tahun 2019. Berdasarkan analisis jaringan topik penelitian, diperoleh tujuh klaster penelitian, masing-masing menampilkan berbagai topik yang saling terkait. Topik-topik yang berpeluang untuk diteliti lebih lanjut, yaitu self-esteem, self-efficacy, coping style, dan optimism yang merupakan faktor internal, serta perceived social support dan college counselling sebagai faktor eksternal. Temuan-temuan ini menawarkan wawasan yang berharga bagi para peneliti, praktisi, danpembuat kebijakan, sehingga dapat berkontribusi dalam mewujudkan kesehatan mental untuk semua.
Analysis Of Customer Satisfaction at PT. Sela Kontes Produksi Using Servqual, CSI, And IPA Methods
Authors: Kurniawan Mohammad Yazid , Widyaningrum Dzakiyah 
Published: June 2024

PT. Sela Kontes Produksi is a company in Gresik district that organizes services for children's photo competition events. A significant decrease in participants is a problem PT Sela Kontes Produksi faces due to unresolved customer complaints. This research aimed to determine customer satisfaction with service quality and evaluate the level of service at PT Sela Kontes Produksi. The methods used are Servqual (Service Quality), CSI (Customer Satisfaction Index), and IPA (Importance Performance Analysis). Data was collected by distributing questionnaires to 60 respondents who were service users of PT Sela Kontes Produksi. The results of all questionnaire variables distributed were declared valid and reliable. Servqual data processing results in 7 attribute variables getting negative servqual scores, namely variable T1 (-0.10), T2 (-0.07), T3 (-0.10), T4 (-0.05), RS1 (-0.01), E3 (-0.07), E4 (-0.03). The results of CSI processing are known to get a value of 84.56%, which means that customers are "delighted" with the services provided. The results of IPA data processing show that the T4 variable is in quadrant 1, which means that this variable is the top priority for quality improvement. Keywords: Customer Satisfaction, Servqual, CSI, IPA
Risk Mitigation Design for Supply Chain Activities in Printing Industry with House of Risk Method
Authors: Suaib Robih Alfian Hastrianda , Mansur Agus , Basuki Demas Emirbuwono , Aulia Baiq Putri Rizka 
Published: June 2024

Alvian MSMEs is a company engaged in printing, which serves ordering calendars, banners or billboards. The problem faced by Alvian MSMEs today is supply chain activities and production that are usually late so that products experience a decrease in buying interest from customers. To overcome these problems, MSMEs mitigate risks in supply chain and production activities using the HOR (House Of Risk) Method. Based on Hor phase 1, 12 risk events and risk agents were obtained. The identification results show that the highest risk agent is low-quality raw materials (A9). This risk agent has the highest value because it can cause risk events in the form of poor quality or defects (E9). In HOR phase 2, 6 priorities were obtained for risk mitigation to prevent system failure (PA3), implementing preventive maintenance routines is a top priority. With an ETDk value of 10386, PA3 mitigation measures can reduce risk factors such as manufacturing defects, misconceptions of customer specifications, and quality testing problems, improper maintenance, overuse, system failure, technical problems with printing machines, staff or management failures, no routine monitoring of machine checks (A11,A8,A4,A5,A7).
A Literature Review: Relationship between Interleukin-1 Beta and the Severity of COVID-19
Authors: Maghfirah Andi Ita , Esa Tenri , Bahrun Uleng 
Published: June 2024

COVID-19 disease can cause dysregulation of the immune system, resulting in a cytokine storm. One of the cytokines released is IL-1B, a proinflammatory cytokine due to macrophage stimulation. This study aimed to provide a literature review of the value of Interleukin-1 beta (IL-1B) in patients with severity of COVID-19. This literature review was carried out using the search engines PubMed, Open Accessed Journal, Science Direct, and Google Scholar from December 2019 to December 2022. No studies suggested that IL-1B was associated with the severity of COVID-19. IL-1B is vital during the acute inflammatory response and helps T cells by linking innate and adaptive immunity as a lymphocyte activation factor. A gradual decrease in lymphocyte count was reported in severe COVID-19 diseases. The substantial reduction in lymphocyte count indicates that the SARS-CoV-2 virus increases immune cells and inhibits cellular immunity. This result might explain why IL-1B levels in mild COVID-19 were not significantly different from IL-1B levels in severe COVID-19. There was an increase in IL-1B levels in COVID-19 patients, but there was no relationship between IL-1B and the severity of COVID-19.
Antimicrobial, Antifungal, Antioxidant Activity and Phytochemical Investigation of Phenolcarboxylic Acids by GC–MS of Raspberry (Rubus idaeus L.) Shoot Lipophilic Extract
Authors: Maslov O. , Komisarenko M. , Ponomarenko S. , Kolisnyk S. , Osolodchenko T. , Golik M. 
Published: June 2024

Abstract

Aim
To determine the content of phenolcarboxylic acids using gas chromatography–mass spectrometer (GC–MS) in the obtained extract, conduct a study of the antimicrobial, antifungal, and antioxidant activities of Rubus idaeus shoot lipophilic extract.

Material/methods
The quantification of phenolcarboxylic was accomplished through GC–MS, antioxidant activity was assessed by potentiometric method, antimicrobial and antifungal activities were determined by well method.

Results
The 8 compounds were identified by the GC–MS method. The vanillic acid (2.59 ± 0.08 mg/100 g), benzoic acid (1.51±0.08 mg/100 g), and ferulic acid (0.79±0.04 mg/100 g) dominated in the obtained lipophilic R. idaeus shoot extract. Bacillus subtilis (17.00 ± 0.50 mm) was the most sensitive to lipophilic extract, whereas Proteus vulgaris was the most resistant to the lipophilic extract. Moreover, Candida albicans was medium sensitive to lipophilic extract (13.50 ± 0.50 mm). The antioxidant activity was 1.00 mmol-equiv./mdry res; according to Maslov's antioxidant level classification it has low level.

Conclusions
The lipophilic extract from R. idaeus shoots contains various phenolcarboxylic acids, including vanillic acid, benzoic acid, ferulic acid, p-hydroxybenzoic acid, syringic acid, gentisic acid, salicylic acid, and phenylacetic acid, with the highest concentrations observed for vanillic, benzoic, and ferulic acids. This study highlights the antimicrobial and antifungal properties of the R. idaeus shoot lipophilic extract. However, the obtained lipophilic extract showed a relatively low level of antioxidant activity. Consequently, the derivatives of phenolcarboxylic acids play a substantial role in the antimicrobial and antifungal effects, whereas their contribution to antioxidant activity appears to be limited.
Pemikiran HAMKA tentang Praktik Beragama Orang Minangkabau
Authors: Zikri Adhiya Alfi , Zulqaiyyim Zulqaiyyim 
Published: June 2024

This article aims to explain the condition of religious practices in Minangkabau in the early 20th century through the works of HAMKA. This study uses a historical method approach. Literature review is conducted to obtain primary and secondary sources. From the literature study, books by Haji Abdul Malik Karim Amrullah and other related writings related to the two figures related to the research theme were obtained. HAMKA criticized the practice of tarekat that did not conform to the teachings of the Quran and Hadith, as well as the traditional social system that was not in accordance with Islamic rules, such as in the case of inheritance and communal land. He also brought a new spirit in his preaching with a focus on the spirit of Islamic struggle and unity, as well as criticism of the rigidity of tradition and the importance of education to open up people's perspectives.
Meneropong Morfologi Kota Pekanbaru pada Era Kolonial Belanda (1919-1942)
Authors: Sabrina Sabrina , Zulqaiyyim Zulqaiyyim 
Published: June 2024

This study discusses the morphology changes of Pekanbaru City during the two decades of the Dutch colonial era (1919-1942). This study had used historical research methods with a city morphology perspective. The stages had been heuristics, source criticism, interpretation, and historiography. During that time, Pekanbaru had been developed by the Dutch Colonial Government as an administrative center and trading center. In order to develop that function, the Dutch Colonial Government had built a rubber plantation as a trading commodity at the Pekanbaru Port, which was on the banks of the Siak River. They had also built infrastructure, educational, medical, recreation facilities, etc., so that this city had become attractive to urbanites, resulting in an increase in population. Therefore, a new area of the city had been built to the south so that a morphological transformation had occurred in that city. Thus, in 1919-1942, Pekanbaru had become the administrative center and trade center to support the surrounding plantations.
The potential inflammatory biomarker of bipolar disorder: Neutrophil-to-lymphocyte Ratio – A hospital-based cross-sectional study
Authors: Raj Rajnish , Wani Zaid Ahmad , Dar Shabir Ahmad , Dilawar Tabasum , Altaf Sameera , Beigh Arouf , Haq Inaamul 
Published: June 2024

Objectives:
Inflammation has been hypothesized as one of the pathophysiological factor for mood disorders. The neutrophil-to-lymphocyte ratio (NLR) has been proposed as a potential peripheral biomarker of mood episodes, as this is an economical and accessible marker of inflammation. This study aims to determine the role of inflammation in the pathophysiology of bipolar disorder (BD) and the potential of NLR as a marker for differentiating mood disorders.

Materials and Methods:
A cross-sectional study was conducted on 195 patients who met the inclusion criteria, of whom 80 were diagnosed with BD (mania), 47 with BD (depression), and 68 with major depressive disorder (MDD). Sociodemographic details and a blood sample were taken for hemogram measures. The NLR and MLR were calculated using the following formula: NLR = neutrophil count/lymphocyte count and MLR = monocyte count/lymphocyte count, and statistical analysis was done.

Results:
The mean age (±standard deviation) of patients with mania, bipolar depression, and MDD were 35.97 (±13.14), 39.27 (±14.28), and 33.41 (±13.21) years, respectively, with an almost equal representation of male and female gender. The NLR ratio of 2.41 ± 0.84 was highest in BD (mania), followed by 1.75 ± 0.41 in bipolar depression and 1.67 ± 0.45 in MDD, which was significant (P < 0.001), while MLR ratio in BD (mania) was highest, followed by MDD and bipolar depression.

Conclusion:
Our result indicates NLR as a marker of differentiation and, thus, strengthens the pathophysiological importance of inflammation in mood disorders.
إمكانية تطبيق الشمول المالي في جامعة زاخو "دراسة استطلاعية لآراء عينة من أعضاء هيئة التدريس"
Authors: جبار دلشاد , سلطان حكمت 
Published: June 2024

تسعى الدراسة إلى توضيح مدى توافر الشمول المالي لدى التدريسيين في جامعة زاخو، وكذلك إمكانية تطبيق فلسفة الشمول المالي بشكل ألكتروني ومدى أهميتها بالنسبة للتدرسيين في القيام بأنشطتهم وفعالياتهم سواء في شراء المصادر أو نشر البحوث في المجلات العلمية العالمية، والوقوف على نسب اعتماد الشمول المالي في العينة المبحوثة وأهم التحديات التي تواجه آخرين في عدم تبني هذا المفهوم وقد استخدم الباحثان على المنهج الوصفي لقياس واستكمال متطلبات الدراسة أعتماداً على الاستبانة كأداة رئيسية لجمع البيانات عن أفراد العينة والبالغ عددها (78) وتم تحليل البيانات من خلال البرامج الاحصائي (SPSS. Ver-25).
وقد توصل الباحثان إلى جملة من الاستنتاجات من أهمها إن جودة الخدمات المالية تحتل المرتبة الاولى من إهتمام المبحوثين في الشمول المالي في حين حل استخدام الخدمات المالية وتقنياتها في المرتبة الاخيرة من اهتماماتهم وقد قدم الباحثان مجموعة من المقترحات كان من أهمها تحسين جودة الخدمات المصرفية لإستقطاب أكبر عدد ممكن من الزبائن وتوفير تقنيات تسهيل من مهمة الحصول على الخدمة المالية بسهولة وسرعة وأمان.
Determination of drilling fluid volume for main pipeline crossings construction by direct pipe method
Authors: Исламов Искандар Рамилович , Шарафутдинов Зариф Закиевич , Петров Сергей Олегович , Капаев Рим Амерханович , Соколова Виктория Владимировна 
Published: June 2024

В работе рассмотрены вопросы расхода буровых растворов в процессе сооружения переходов магистральных трубопроводов методом горизонтального направленного бурения щитом. При реализации данного метода строительство осуществляется путем продавливания плети трубопровода одновременно с разработкой и извлечением выбуренной породы, транспортируемой с использованием буровых растворов в виде пульпы по внутренним магистралям (трубопроводам). Определение объема бурового раствора является одной из задач при планировании строительства переходов трубопроводов с использованием рассматриваемой технологии с целью прогнозирования расхода раствора и формирования его компонентного состава для успешной реализации проходки. Авторами разработана комплексная методика определения общего объема бурового раствора при прокладке трубопроводов методом горизонтально-направленного бурения щитом.
The paper considers the issues of drilling fluids consumption during the construction of main pipeline crossings by the direct pipe method. The method allows you to push through the lash of the pipeline simultaneously with the development and extraction of drilled rock in the ground mass with drilling fluid. There are two different types of drilling fluids – pumped into the annular space and used directly in the drilling process by machine’s cutterhead. The need to determine the volume of drilling mud is due to the technology of conducting the construction process, the discreteness of the use of drilling mud for the passage of a particular engineering and geological element along the profile of the site in order to predict its consumption, including the number of its components for the implementation of sinking. The article proposes a system for calculating the total drilling fluid volume during the laying of main pipelines by the direct pipe method.
Experimental determination of elastic-plastic fracture toughness of pipes using non-standard samples
Authors: Матвиенко Юрий Григорьевич , Кузьмин Дмитрий Александрович , Москвитин Геннадий Викторович , Пугачев Максим Сергеевич , Потапов Владимир Вячеславович 
Published: June 2024

С целью повышения точности экспериментального определения упругопластической вязкости разрушения тонкостенных труб малого диаметра предложено использовать нестандартные образцы, применение которых позволит исключить технологические операции по выпрямлению образцов, вносящие в металл дополнительные изменения. Представлены методика и результаты экспериментального определения поправочного коэффициента η и упругопластической вязкости разрушения труб с использованием нестандартных образцов. Методика основана на методе сепарабельных функций. Дано подробное описание метода сепарабельных функций. Приведены результаты определения упругопластической вязкости разрушения труб на двух типах образцов, вырезанных из труб марки стали 20: дугообразном образце с краевой трещиной в условиях внецентренного растяжения и кольцевом образце с двумя диаметральными трещинами в условиях трехточечного изгиба. Отмечено, что поправочный коэффициент η для дугообразного образца с трещиной в условиях внецентренного растяжения практически совпадает с коэффициентом η для стандартного компактного образца при внецентренном растяжении. В то же время поправочный коэффициент η для кольцевого образца с двумя диаметрально противоположными трещинами значительно отличается от коэффициента η для плоского образца с краевой трещиной в условиях трехточечного изгиба.
To improve the accuracy of the experimental determination of the elastic-plastic fracture toughness of thin walled pipes of small diameter, it is proposed to use non-standard samples, the use of which will eliminate technological operations for straightening samples that make additional changes to the metal. The methodology and results of experimental determination of the correction coefficient n and the elastic-plastic fracture toughness of pipes using non-standard samples are presented. The technique is based on the method of separable functions. A detailed description of the method of separable functions is given. The results of determining the elastic-plastic fracture toughness of pipes on two types of samples cut from steel grade 20 pipes are presented: an arc-shaped sample with an edge crack under conditions of off-center stretching and an annular sample with two diametrical cracks under conditions of three-point bending. It is noted that the correction coefficient з for an arc-shaped sample with a crack under conditions of off-center tension practically coincides with the coefficient n for a standard compact sample under off-center tension. At the same time, the correction coefficient з for an annular sample with two diametrically opposite cracks differs significantly from the coefficient з for a flat sample with an edge crack under three-point bending conditions.
Determination of The Essential Micro Element Content of Padina sp from Lemukutan Waters as a Biostimulant Candidate
Authors: Ashari Asri Mulya , Apindiati Rita Kurnia 
Published: June 2024

The search for biostimulant candidates to increase plant fertility is increasingly being encouraged, especially in utilizing abundant marine resources. Padina sp seaweed, which is widely found in Lemukutan waters, is a type of brown seaweed that is not widely used by the local community, and tends to be considered a weed. Determination of micromineral levels in Padina sp using the atomic absorption spectrophotometry method. The aim of this research is to determine the micro mineral content of iron (Fe), zinc (Zn), manganese (Mn), and copper (Cu) in Padina sp seaweed from the waters of Lemukutan Island as a biostimulant candidate. The research results show that the micro mineral elements Padina sp from Lemukutan waters contain Fe, Zn, Mn and Cu elements of 5.05 ppm, 1.3 ppm, 2.87 ppm and 0.1 ppm respectively. Based on the micro mineral content, it indicates that Padina sp can be used as a basic ingredient for biostimulants in the fields of agriculture and aquaculture.