bluuebunny/crossref_metadata_2025_split huggingface dataset:
Model Kebijakan Pengelolaan dan Pemanfaatan Cagar Budaya Sebagai Potensi Wisata Di Sulawesi Tengah
Authors: Srifridayanti Srifridayanti 
Published: June 2024

Penelitian ini dilakukan dengan maksud dan tujuan agar pemerintah derah bisa mendapatkan model kebijakan yang dapat diterapkan untuk mendukung pengeloaan dan pemanfaat cagar budaya yang ada di Sulawesi Tengah. Metode yang digunakan dalam penelitian ini adalah metode analisis data kualitatif deskriptif dengan pendekatan studi literatur review. Studi Literatur (literature review) merupakan metode penelitian yang dilakukan oleh peneliti dengan mengumpulkan sejumlah buku-buku, majalah, tulisan, artikel ilmiah, atau jurnal yang berkaitan dengan penelitian. metode literatur review adalah metode yang sistematis, eksplisit, dan dapat direproduksi untuk mengidentifikasi, mengevaluasi, dan mensintesis penelitian dan ide-ide yang dihasilkan oleh peneliti dan praktisi. Hasil penelitian menunjukan bahwa pengelolaan dan pengembangan situs cagar budaya oleh Pemerintah daerah Sulawesi Tengah dinilai masih belum optimal. Walaupun pemerintah daerah telah melakukan model kebijakan restorasi dan beberapa upaya pengembangan situs cagar budaya dengan cara mengidentifikasi berbagai macam dan jenis peninggalan tersebut, namun persoalan yang penting seperti tentang regulasi hukumnya masih belum jelas
Engajamento e desengajamento online: um estudo quantitativo com estudantes do ensino superior
Authors: Irala Valesca Brasil , Ortega Fernanda da Cunha 
Published: June 2024

Esta pesquisa de natureza quantitativa foca nos conceitos de engajamento e desengajamento estudantil no modelo online, a partir de uma estrutura conceitual denominada “modelo duplo”. O objetivo central da pesquisa é compreender os processos de engajamento e desengajamento online de estudantes de graduação. Porém, a contribuição da pesquisa não se restringe a essa modalidade, podendo o instrumento já validado ser aplicado e adaptado a outros cenários. O questionário, que foi aplicado junto a 1373 estudantes de graduação, é constituído de 50 itens e abarca as seguintes dimensões de engajamento e desengajamento: comportamental, cognitivo, emocional, agentivo e social. A validação do conteúdo do instrumento foi realizada junto a sete juízes experts, além de análise estatística por meio da análise fatorial confirmatória e da fidedignidade composta. As dimensões de engajamento que se destacaram foram as dimensões cognitivas e comportamentais, já entre os escores de desengajamento, o mais sobressalente foi o emocional. No que diz respeito ao cruzamento de variáveis, observou-se que os adultos mais velhos foram os mais engajados e os jovens adultos os mais desengajados. Por outro lado, não houve diferença nos níveis de engajamento de acordo com o gênero. O estudo releva a importância de maior investimento no desenvolvimento do engajamento agentivo, dado que, assim, pode contribuir para alavancar um maior protagonismo estudantil.
Optimal design of LiMn2O4 for high-rate applications by means of citric acid aided route and microwave heating
Authors: Shmatok Yurii , Potapenko Hanna , Kirillov Sviatoslav 
Published: June 2024

Due to shortening the duration of the process and possibility to obtain crystals of smaller and uniform size, microwave heating is considered an effective and promising tool for the synthesis of LiMn2O4, a valuable cathode material for lithium-ion batteries. However, electrochemical characteristics of LiMn2O4 obtained with its help are almost completely absent and do not allow for drawing a sound conclusion regarding advantages and drawbacks of microwave processing. Here we present a description of the microwave-assisted citric acid aided synthesis, characterization and electrochemical performance of LiMn2O4. The disclosure of detailed working protocols enabling one to manufacture samples tolerant to extremely high currents is the main novelty of this paper. Specifically, our material sustains current loads up to 40 C (5920 mA g-1) and completely recovers after cycling at harsh conditions.
Evaluación de técnicas de inteligencia artificial para predicción de señales de electrocardiograma. Guayaquil. Ecuador. 2023
Authors: Noboa-Terán Cesar Augusto , Ramirez-Hecksher Ana María , Medina-Avelino Jorge Alberto 
Published: June 2024

Las enfermedades cardiovasculares son trastornos del corazón y de los vasos sanguíneos. Su mortalidad es alta y cada año fallecen casi 18 millones de personas en el mundo. El electrocardiograma es usado en medicina para monitorear pequeños cambios eléctricos en la piel del cuerpo de un paciente, emitidos por la actividad del corazón humano. En la actualidad con los avances tecnológicos y la evolución de los algoritmos de inteligencia artificial, se pueden aprovechar las diferentes técnicas de inteligencia artificial, para el análisis de señales de un electrocardiograma, para predecir una patología cardíaca y determinar qué algoritmo es el más adecuado, en la predicción del diagnóstico de una alteración presente.
Objetivo: Probar algoritmos de inteligencia artificial y evaluar su aplicación en la predicción de patologías cardiacas, a través de la introducción de información de electrocardiogramas, en la base de datos abierta de arritmias de MIT-BIH, para visibilizar su utilidad predictiva para alteraciones cardiacas en el ámbito de la medicina.
Material y Método. El estudio se realiza en la Facultad de Ciencias Médicas de la Universidad de Guayaquil, utiliza técnicas de inteligencia artificial para el análisis de señales ECG de la base de datos abierta de arritmias de MIT-BIH.
Conclusión. La evolución de los algoritmos de inteligencia artificial, permiten abordarla en el ámbito de la medicina, para monitorear si es posible predecir eventos cardiacos que complican la salud de los pacientes.
Perancangan Sistem Informasi Manajemen Proyek C’HeTi: Cultural Heritage Technology Virtual Tour Guide Berbasis Mobile
Authors: Galasca Syafhira Ananda , Yahfizham Yahfizham 
Published: June 2024

Sumatera Utara menjadi salah satu daerah wisata favorit baik bagi wisatawan Lokal maupun Mancanegara. jumlah wisatawan yang berkunjung ke Sumatera Utara terus meningkat sepanjang tahun 2023, khususnya wisatawan Mancanegara. Badan Pusat Statistik (BPS) Sumatera Utara (SUMUT) menyatakan bahwa jumlah wisatawan asing yang berkunjung ke Sumatera Utara meningkat sebanyak 164,46% dibandingkan tahun sebelumnya. Meskipun demikian, kurang lengkapnya informasi mengenai tempat wisata masih tidak bisa dihindari. hal ini dapat berakibat pada kurang nya kepuasan wisatawan terhadap kawasan wisata. Masalah lainnya yakni mahalnya jasa tour guide yang tersedia pada Kawasan wisata. Oleh karena itu diperlukan adanya aplikasi yang dapat memberikan pengalaman Virtual Tour sekaligus Tour Guide agar mempermudah para wisatawan yg hendak berkunjung ke daerah wisata tertentu. C’HeTi merupakan aplikasi berbasis mobile yang melibatkan pencarian tempat wisata, kultur lokal wisata dan teknologi yang bertujuan untuk mempermudah wisatawan Ketika hendak mengunjungi tempat wisata. Penelitian ini menggunakan metode Rapid Application Development (RAD) sebagai metode pengembangan nya. Dimana metode ini berfokus pada pengembangan software (perangkat lunak) dalam waktu yang singkat. Aplikasi ini diharapkan dapat membantu wisatawan sekaligus menjadikan pengalaman wisata yang mudah dan menyenangkan sekaligus dapat terus meningkatkan grafik wisatawan lokal maupun mancanegara di Sumatera Utara.
Minimum 10-year follow-up outcomes of arthroscopic Bankart’s repair with metallic anchors: Reliable results with low redislocation rates
Authors: Gupta Prateek Kumar , Khanna Vishesh , Agrawal Nikunj , Gupta Pratyaksh 
Published: June 2024

BACKGROUND
With stiff competition from alternative albeit more expensive counterparts, it has become important to establish the applicability of metallic anchors for shoulder instability in the modern era. This can be accomplished, in part, by analysing long-term outcomes.
AIM
To analyse minimum 10-year outcomes from 30 patients following arthroscopic anterior stabilisation using metallic anchors.
METHODS
Prospectively collected data from arthroscopic Bankart repairs performed using metal anchors during 2007P-2010 were retrospectively analysed in this single-surgeon study. Comprehensive data collection included historical and clinical findings, dislocation details, operative specifics, and follow-up radiological and clinical findings including shoulder scores. The primary outcomes were patient-reported scores (Constant, American Shoulder and Elbow Surgeons [ASES], and Rowe scores) and pain and instability on a visual analogue scale (VAS).
RESULTS
A 3% recurrence rate of dislocation was noted at the final follow-up. Total constant scores at 10 years postoperatively measured between 76 and 100 (mean 89) were significantly better than preoperative scores (mean 62.7). Congruous improvements were also noted in the Rowe and ASES scores and VAS at the 10-year review.
CONCLUSION
Reliable long-term outcomes with metallic anchors in surgery for shoulder instability can be expected. Our results provide additional evidence of their continued, cost-effective presence in the modern scenario.
Digestive and breast cancer patients managed during the first wave of COVID-19 pandemic: Short and middle term outcomes
Authors: Trébol Jacobo , Carabias-Orgaz Ana , Esteban-Velasco María Carmen , García-Plaza Asunción , González-Muñoz Juan Ignacio , Sánchez-Casado Ana Belén , Parreño-Manchado Felipe Carlos , Eguía-Larrea Marta , Alcázar-Montero José Antonio 
Published: June 2024

BACKGROUND
The first wave of coronavirus disease 2019 (COVID-19) pandemic in Spain lasted from middle March to the end of June 2020. Spanish population was subjected to lockdown periods and scheduled surgeries were discontinued or reduced during variable periods. In our centre, we managed patients previously and newly diagnosed with cancer. We established a strategy based on limiting perioperative social contacts, preoperative screening (symptoms and reverse transcription-polymerase chain reaction) and creating separated in-hospital COVID-19-free pathways for non-infected patients. We also adopted some practice modifications (surgery in different facilities, changes in staff and guidelines, using continuously changing personal protective equipment…), that supposed new inconveniences.
AIM
To analyse cancer patients with a decision for surgery managed during the first wave, focalizing on outcomes and pandemic-related modifications.
METHODS
We prospectively included adults with a confirmed diagnosis of colorectal, oesophago-gastric, liver-pancreatic or breast cancer with a decision for surgery, regardless of whether they ultimately underwent surgery. We analysed short-term outcomes [30-d postoperative morbimortality and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection] and outcomes after 3 years (adjuvant therapies, oncological events, death, SARS-CoV-2 infection and vaccination). We also investigated modifications to usual practice.
RESULTS
From 96 included patients, seven didn’t receive treatment that period and four never (3 due to COVID-19). Operated patients: 28 colon and 21 rectal cancers; laparoscopy 53.6%/90.0%, mortality 3.57%/0%, major complications 7.04%/25.00%, anastomotic leaks 0%/5.00%, 3-years disease-free survival (DFS) 82.14%/52.4% and overall survival (OS) 78.57%/76.2%. Six liver metastases and six pancreatic cancers: no mortality, one major complication, three grade A/B liver failures, one bile leak; 3-year DFS 0%/33.3% and OS 50.0%/33.3% (liver metastases/pancreatic carcinoma). 5 gastric and 2 oesophageal tumours: mortality 0%/50%, major complications 0%/100%, anastomotic leaks 0%/100%, 3-year DFS and OS 66.67% (gastric carcinoma) and 0% (oesophagus). Twenty breast cancer without deaths/major complications; 3-year OS 100% and DFS 85%. Nobody contracted SARS-CoV-2 postoperatively. COVID-19 pandemic–related changes: 78.2% treated in alternative buildings, 43.8% waited more than 4 weeks, two additional colostomies and fewer laparoscopies.
CONCLUSION
Some patients lost curative-intent surgery due to COVID-19 pandemic. Despite practice modifications and 43.8% delays higher than 4 weeks, surgery was resumed with minimal changes without impacting outcomes. Clean pathways are essential to continue surgery safely.
Non-enzymatic methods for isolation of stromal vascular fraction and adipose-derived stem cells: A systematic review
Authors: Mundluru Vamsi Krishna , Naidu MJ , Mundluru Ravi Teja , Jeyaraman Naveen , Muthu Sathish , Ramasubramanian Swaminathan , Jeyaraman Madhan 
Published: June 2024

BACKGROUND
Adipose-derived stem cells (ADSCs) and the stromal vascular fraction (SVF) have garnered substantial interest in regenerative medicine due to their potential to treat a wide range of conditions. Traditional enzymatic methods for isolating these cells face challenges such as high costs, lengthy processing time, and regu-latory complexities.
AIM
This systematic review aimed to assess the efficacy and practicality of non-enzymatic, mechanical methods for isolating SVF and ADSCs, comparing these to conventional enzymatic approaches.
METHODS
Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, a comprehensive literature search was conducted across multiple databases. Studies were selected based on inclusion criteria focused on non-enzymatic isolation methods for SVF and ADSCs from adipose tissue. The risk of bias was assessed, and a qualitative synthesis of findings was performed due to the methodological heterogeneity of the included studies.
RESULTS
Nineteen studies met the inclusion criteria, highlighting various mechanical techniques such as centrifugation, vortexing, and ultrasonic cavitation. The review identified significant variability in cell yield and viability, and the integrity of isolated cells across different non-enzymatic methods compared to enzymatic procedures. Despite some advantages of mechanical methods, including reduced processing time and avoidance of enzymatic reagents, the evidence suggests a need for optimization to match the cell quality and therapeutic efficacy achievable with enzymatic isolation.
CONCLUSION
Non-enzymatic, mechanical methods offer a promising alternative to enzymatic isolation of SVF and ADSCs, potentially simplifying the isolation process and reducing regulatory hurdles. However, further research is necessary to standardize these techniques and ensure consistent, high-quality cell yields for clinical applications. The development of efficient, safe, and reproducible non-enzymatic isolation methods could significantly advance the field of regenerative medicine.
THE EFFECTIVENESS OF REGIONAL GOVERNMENT EMPOWERMENT ON PHARMACEUTICAL WHOLESALER LICENSES ON THE BALI PROVINCE
Authors: Joniada I Made Wisnu , Styawati Ni Komang Arini , Arjaya I Made 
Published: June 2024

Pharmaceutical wholesalers (PBF) that are already licensed by Indonesian government have complied with the pre-operational business standard requirements and during operations are required to comply with the standards of good drug distribution procedures. However, there have been some cases of PBFs that have been licensed infringing on their business licensing obligations. These infringements will affect the quality of drugs and/or drug substances which could endanger consumers. Based on this phenomenon, monitoring by regional governments is important in maintaining businesses’ compliance with business standards. The objectives of this research were to examine and analyze several factors affecting the effectiveness of regional government supervision of PBF licenses in Bali Province. The method used is empirical legal method. To address the issues within this research, the author utilizes a sociological approach, a legal regulation approach, and a conceptual approach. Furthermore, this research indicated that Bali Provincial Health Office supervision is ineffective in assuring compliance in the fulfilling of requirements and obligations by businesses. These conditions have been affected through legal substantial factors, legal structure, and legal culture.
THE IMPERATIVE OF STATE FINANCIAL RESTITUTION IN ANTI-CORRUPTION ERADICATION MEASURES
Authors: Putra Muhamad Gempa Awaljon , Usman Dr. Usman , Satoto Prof. Dr. Sukamto 
Published: June 2024

Corruption is defined as a white-collar crime that mostly affects public authorities. In addition, corruption is categorized as an outstanding crime because it obstructs the people’s economy and national development. Uncontrollable corrupt practices will have a comprehensive impact on a country’s government system and can serve to further disrupt future governance. Therefore, the restoration and return of state financial losses from corruption is a high priority in upholding legislation and penal law in Indonesia. The objective of this research is examine several corruption crimes in Indonesia, their eradication efforts, and state governments’ attempts in restitution of state financial losses caused by corruption offenses. A normative juridical research method was used in this research, combined with legislative approach, case approach, comparison approach, and theoretical approach. The research concluded that corruption offenses are divided into seven categories of offenses that can lead to losses of state finances. The eradication of on Indonesia's corruption has been realized since the New Order until now.
Advances in Human Leukocyte Antigen Testing Technologies and Management Strategies for Platelet Transfusion Refractoriness
Authors: Sullivan H. Cliff , Borge P. Dayand , Gammon Richard R. , Gandhi Manish , Philogene Mary C. , Wu YanYun , Kopko Patricia M. 
Published: June 2024

Context.—
The blood bank is often consulted for transfusion support of patients with suspected platelet transfusion refractoriness (PTR). The workup is complex because testing includes specialized assays that are uncommonly ordered with limited availability. Add to this the variety of possible products—crossmatched platelets, human leukocyte antigen (HLA)–matched platelets, HLA antigen–negative platelets—and the approach to PTR can be overwhelming. Moreover, most literature on the subject is published in transfusion medicine journals aimed at transfusion medicine physicians and blood bank specialists in academic settings. Resources tailored to community hospital blood banks are lacking.

Objective.—
To provide pathologists who may not have subspecialized training in transfusion medicine and who direct blood banks algorithmic workflows based on clinical scenario and test availability to provide appropriate transfusion support for patients with PTR.

Data Sources.—
This review is a comprehensive overview of terminology, HLA testing procedures, interpretations, and practical recommendations for managing PTR in various scenarios based on expert opinion as well as relevant medical literature published from 2007 to 2022.

Conclusions.—
Consultation on PTR is complicated and encompasses many clinical and laboratory aspects. The lack of guidelines derived from high-quality prospective studies poses challenges in the workup and management of PTR. Hindering the process further are limited test availability, unfamiliarity with the technical assays, and the various specialized platelet products. The clinical evaluation algorithm presented herein along with the workflow pathways offer pathologists user-friendly and best-practice guidelines with different options based on the clinical scenario and the tests available.
The Diagnostic Accuracy of Claudin-4 Immunochemistry in Differentiating Metastatic Carcinomas From Mesothelial Processes in Serous Effusion Cytology: A Systematic Review and Meta-analysis
Authors: Kleinaki Maria , Vey Johannes A. , Awounvo Sinclair , Ishak Angela , Arnaouti Maria , Ryu Han Suk , Nikas Ilias P. 
Published: June 2024

Context.—
Distinguishing metastatic carcinomas from mesotheliomas or reactive mesothelial cells in pleural, peritoneal, and pericardial effusions is a common diagnostic problem cytopathologists encounter.

Objective.—
To perform the first meta-analysis on the pooled diagnostic accuracy of claudin-4 immunochemistry in serous effusion cytopathology.

Design.—
This report followed the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines for diagnostic test accuracy studies. Three databases (PubMed, Scopus, and the Cochrane Library) were searched until October 9, 2023, followed by study selection using specific inclusion and exclusion criteria and data extraction. The study quality assessment was performed by using the Quality Assessment of Diagnostic Accuracy Studies 2 (QUADAS-2) tool. Statistical analysis was performed by using R to calculate the pooled sensitivity and specificity of claudin-4 immunochemistry. In addition, the diagnostic odds ratio was measured, representing the odds ratio of a positive result indicating a carcinoma rather than a mesothelial process in serous effusion cytology.

Results.—
Fourteen observational studies, published between 2011 and 2023, fulfilled the selection criteria and were included. All 14 studies used the 3E2C1 clone. Claudin-4 immunochemistry showed a high diagnostic accuracy in serous effusion cytology. The pooled sensitivity and specificity were 98.02% (95% CI, 93.96%–99.37%) and 99.72% (95% CI, 97.36%–99.97%), respectively. Lastly, the pooled diagnostic odds ratio was 1660.5 (95% CI, 760.0–3627.8) and no evidence of statistical heterogeneity between the included studies was found (I2 = 0%, τ2 = 0).

Conclusions.—
Claudin-4 may be used as a single pan-carcinoma immunochemical biomarker in the differential diagnosis between metastatic carcinomas and mesotheliomas or reactive mesothelial cells in serous effusion cytology.
Development and optimization of self-microemulsifying astaxanthin delivery system using the design of experiment (doe) approach
Authors:   , Zin Mo 
Published: June 2024

The purpose of this research was to develop and optimize a self-microemulsifying delivery system (SMEDS) to improve dissolution rate of poor soluble compound AST by mixture experimental design. The solubility of AST was analyzed with various excipients so that the appropriate oil, surfactant, and cosurfactant were figured out. Through the findings about the microemulsion existence area, the pseudoternary phase diagrams were constructed for selecting the optimum combination of excipients in a formulation of SMEDS. The optimized LCT-SMEDS obtained from the design space was composed of 19.59% castor oil (oil; X1), 62.34% Cremophor® RH 40 (surfactant; X2), and 18.03% Tween® 80 (cosurfactant; X3) as independent variables, which resulted in a droplet size of 20.71 nm (Y1), PDI of 0.28 (Y2), zeta potential of -9.07 mV (Y3), 97.87% active ingredient content (Y4), and 98.38% transmittance (Y5) as response factors. The optimized MCT-SMEDS consisted of 12.39% MCT (oil; X1), 44.98% Cremophor® RH 40 (surfactant; X2), and 44.59% Tween® 80 (cosurfactant; X3) as independent variables, which resulted in a droplet size of 22.02 nm (Y1), PDI of 0.17 (Y2), zeta potential of -10.69 mV (Y3), 98.72% transmittance (Y4), and 97.09% active ingredient content (Y5) as response factors. The desirability function values of LCT-SMEDS and MCT-SMEDS were 0.8074 and 0.7949, respectively, indicating the reliability and accuracy of optimization. In addition, good agreement was found between the model prediction and experimental values of Y1, Y2, Y3, Y4, and Y5. Optimized formulations of LCT-SMEDS and MCT-SMEDS were characterized by visual observation, self-emulsification time, refractive index, transmission electron microscopy (TEM), freeze-thaw stability studies showing rapid microemulsion with good physicochemical properties and stability. The dissolution of the optimized LCT-SMEDS and MCT-SMEDS was pH-independent and reached over 90% within 4 hrs in all the media tested. As stated in the results, the significant improvements of SMEDS formulations were found in dissolution profiles of AST, compared to a marketed preparation and raw AST. Thus, we suggested that SMEDS formulation using the experimental design method might be a promising way to improve the dissolution of poorly water-soluble substance astaxanthin.