bluuebunny/crossref_metadata_2025_split huggingface dataset:
The sum of all victories? Reassessing a Sinopean victory catalogue (IK Sinope 105)
Authors: Wu Ching-Yuan 
Published: April 2024

AbstractThis study reassesses an inscribed victory catalogue from Sinope (IK Sinope 105) that is often discussed in scholarship concerning agonistic culture in the Roman world. One particularly curious element of this inscription is the empty nature of the penultimate line, which bears only the numerals rho-nu. In the existing scholarship, this is usually interpreted as the sum of all the athlete’s victories. This paper challenges the orthodox interpretation, using a combination of David French’s squeezes housed at the British Institute at Ankara, supported by autopsy and recent photographs of the stone itself. It goes on to reconsider the practice of summing athletic victories in honorific inscriptions more generally, examining a specially compiled dossier of 207 inscriptions of comparable date to IK Sinope 105, and concluding that the practice was relatively rare. Finally, this paper considers other possible interpretations of the rho-nu in IK Sinope 105, among which is the suggestion that rho-nu could be a chronographic feature. While the interpretation of the rho-nu in IK Sinope 105 remains open, the combination of a close analysis of the stone with a wider contextual consideration of the genre demonstrates how much more remains to be said about even a well-known and often cited inscription.
Effect of venlafaxine on anhedonia and amotivation in patients with major depressive disorder
Authors: McIntyre Roger S. , Agid Ofer , Biesheuvel Egbert , Purushottamahanti Pradeep 
Published: April 2024

AbstractObjectiveSerotonin norepinephrine reuptake inhibitors (SNRIs) have been postulated to afford benefits in alleviating anhedonia and amotivation. This post hoc pooled analysis evaluated the effect of venlafaxine XR, an SNRI, on these symptoms in patients with major depressive disorder (MDD).MethodsData was pooled from five short-term randomized, placebo-controlled studies of venlafaxine XR for the treatment of MDD, comprising 1087 (venlafaxine XR, n = 585; placebo, n = 502) adult subjects. The change from baseline score in the MADRS anhedonia factor (based on items 1 [apparent sadness], 2 [reported sadness], 6 [concentration difficulties], 7 [lassitude], and 8 [inability to feel]) for anhedonia, and in motivational deficits (based on 3 items of HAM-D17: involvement in work and activities, psychomotor retardation, and energy level [ie, general somatic symptoms]) for amotivation, were measured through 8 weeks. Mixed model repeated measures (MMRMs) were used to analyze changes over time and ANCOVA to analyze the change from baseline at week 8 with LOCF employed to handle missing data.ResultsAt the end of 8 weeks, the change from baseline was significantly greater in patients on venlafaxine XR in both anhedonia (mean, 95% CI: −2.73 [−3.63, −1.82], p < 0.0001) and amotivation scores (mean, 95% CI: −0.78 [−1.04, −0.52], p < 0.0001) than those on placebo. For both measures, the between-group separation from baseline was statistically significant starting from week 2 onwards, and it increased over time.ConclusionThis analysis demonstrates that venlafaxine XR is effective in improving symptoms of anhedonia and motivational deficits in patients with MDD.
Sexuelle Inaktivität und sexuelle Unzufriedenheit bei Paaren in der mittleren Lebensphase nach im Mittel 31 Jahren Beziehungsdauer
Authors: Job Ann-Katrin , Hahlweg Kurt , Schulz Wolfgang , Supke Max 
Published: April 2024

Zusammenfassung: Theoretischer Hintergrund. Sexuelle Aktivität und Erleben verändern sich über die Lebensspanne. Unabhängig vom Alter ist ein reduziertes bzw. fehlendes sexuelles Verlangen die am häufigsten berichtete sexuelle Problematik. Es fehlen Studien an Paaren in langjährigen stabilen Partnerschaften. Fragestellung. Ziel war, die sexuelle Inaktivität und Unzufriedenheit von Paaren in der mittleren Lebensphase zu untersuchen. Methode. Es wurden Daten des 18-Jahres Follow-Ups der Längsschnittstudie „ Zukunft Familie“ verwendet. Zu diesem Zeitpunkt lebten noch N = 150 (53 %) Paare zusammen (Frauen: M = 54.1 Jahre; Männer: M = 56.5 Jahre); mittlere Beziehungsdauer: 31 Jahre. Ergebnisse. Von den Frauen gaben 39 % sexuelle Inaktivität an (erfasst über die Häufigkeit des Geschlechtsverkehrs). Mit ihrer Sexualität waren 27 % (eher) unzufrieden. Sexuelle Zufriedenheit korrelierte bei Frauen und Männern positiv mit Partnerschaftszufriedenheit, höherer Lebensqualität und guter sozialer Unterstützung sowie negativ mit Ängstlichkeit und Depressivität. Schlussfolgerungen. Sexuelle Inaktivität im mittleren Lebensalter ist von psychosozialen Faktoren abhängig. Spezifische Interventionen für betroffene Paare sollten entwickelt und evaluiert werden.
Glutamine-mediated epigenetic regulation of cFLIP underlies resistance to TRAIL in pancreatic cancer
Authors: Kim Ji Hye , Lee Jinyoung , Im Se Seul , Kim Boyun , Kim Eun-Young , Min Hyo-Jin , Heo Jinbeom , Chang Eun-Ju , Choi Kyung-Chul , Shin Dong-Myung , Son Jaekyoung 
Published: April 2024

AbstractTumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising anticancer agent because it kills cancer cells while sparing normal cells. However, many cancers, including pancreatic ductal adenocarcinoma (PDAC), exhibit intrinsic or acquired resistance to TRAIL, and the molecular mechanisms underlying TRAIL resistance in cancers, particularly in PDAC, remain unclear. In this study, we demonstrated that glutamine (Gln) endows PDAC cells with resistance to TRAIL through KDM4C-mediated epigenetic regulation of cFLIP. Inhibition of glutaminolysis significantly reduced the cFLIP level, leading to TRAIL-mediated formation of death-inducing signaling complexes. Overexpression of cFLIP dramatically rescued PDAC cells from TRAIL/Gln deprivation-induced apoptosis. Alpha-Ketoglutarate (aKG) supplementation significantly reversed the decrease in the cFLIP level induced by glutaminolysis inhibition and rescued PDAC cells from TRAIL/Gln deprivation-induced apoptosis. Knockdown of glutamic-oxaloacetic transaminase 2, which facilitates the conversion of oxaloacetate and glutamate into aspartate and aKG, decreased aKG production and the cFLIP level and activated TRAIL-induced apoptosis. AKG-mediated epigenetic regulation was necessary for maintaining a high level of cFLIP. Glutaminolysis inhibition increased the abundance of H3K9me3 in the cFLIP promoter, indicating that Gln-derived aKG production is important for Jumonji-domain histone demethylase (JHDM)-mediated cFLIP regulation. The JHDM KDM4C regulated cFLIP expression by binding to its promoter, and KDM4C knockdown sensitized PDAC cells to TRAIL-induced apoptosis. The present findings suggest that Gln-derived aKG production is required for KDM4C-mediated epigenetic regulation of cFLIP, which leads to resistance to TRAIL.
Genomic deletion of Bcl6 differentially affects conventional dendritic cell subsets and compromises Tfh/Tfr/Th17 cell responses
Authors: Xiao Hongkui , Ulmert Isabel , Bach Luisa , Huber Johanna , Narasimhan Hamsa , Kurochkin Ilia , Chang Yinshui , Holst Signe , Mörbe Urs , Zhang Lili , Schlitzer Andreas , Pereira Carlos-Filipe , Schraml Barbara U. , Baumjohann Dirk , Lahl Katharina 
Published: April 2024

AbstractConventional dendritic cells (cDC) play key roles in immune induction, but what drives their heterogeneity and functional specialization is still ill-defined. Here we show that cDC-specific deletion of the transcriptional repressor Bcl6 in mice alters the phenotype and transcriptome of cDC1 and cDC2, while their lineage identity is preserved. Bcl6-deficient cDC1 are diminished in the periphery but maintain their ability to cross-present antigen to CD8+ T cells, confirming general maintenance of this subset. Surprisingly, the absence of Bcl6 in cDC causes a complete loss of Notch2-dependent cDC2 in the spleen and intestinal lamina propria. DC-targeted Bcl6-deficient mice induced fewer T follicular helper cells despite a profound impact on T follicular regulatory cells in response to immunization and mounted diminished Th17 immunity to Citrobacter rodentium in the colon. Our findings establish Bcl6 as an essential transcription factor for subsets of cDC and add to our understanding of the transcriptional landscape underlying cDC heterogeneity.
Protein mimetic 2D FAST rescues alpha synuclein aggregation mediated early and post disease Parkinson’s phenotypes
Authors: Stillman Nicholas H. , Joseph Johnson A. , Ahmed Jemil , Baysah Charles Zuwu , Dohoney Ryan A. , Ball Tyler D. , Thomas Alexandra G. , Fitch Tessa C. , Donnelly Courtney M. , Kumar Sunil 
Published: April 2024

AbstractAbberent protein-protein interactions potentiate many diseases and one example is the toxic, self-assembly of α-Synuclein in the dopaminergic neurons of patients with Parkinson’s disease; therefore, a potential therapeutic strategy is the small molecule modulation of α-Synuclein aggregation. In this work, we develop an Oligopyridylamide based 2-dimensional Fragment-Assisted Structure-based Technique to identify antagonists of α-Synuclein aggregation. The technique utilizes a fragment-based screening of an extensive array of non-proteinogenic side chains in Oligopyridylamides, leading to the identification of NS132 as an antagonist of the multiple facets of α-Synuclein aggregation. We further identify a more cell permeable analog (NS163) without sacrificing activity. Oligopyridylamides rescue α-Synuclein aggregation mediated Parkinson’s disease phenotypes in dopaminergic neurons in early and post disease Caenorhabditis elegans models. We forsee tremendous potential in our technique to identify lead therapeutics for Parkinson’s disease and other diseases as it is expandable to other oligoamide scaffolds and a larger array of side chains.
Semantic integration of diverse data in materials science: Assessing Orowan strengthening
Authors: Bayerlein Bernd , Schilling Markus , von Hartrott Philipp , Waitelonis Jörg 
Published: April 2024

AbstractThis study applies Semantic Web technologies to advance Materials Science and Engineering (MSE) through the integration of diverse datasets. Focusing on a 2000 series age-hardenable aluminum alloy, we correlate mechanical and microstructural properties derived from tensile tests and dark-field transmission electron microscopy across varied aging times. An expandable knowledge graph, constructed using the Tensile Test and Precipitate Geometry Ontologies aligned with the PMD Core Ontology, facilitates this integration. This approach adheres to FAIR principles and enables sophisticated analysis via SPARQL queries, revealing correlations consistent with the Orowan mechanism. The study highlights the potential of semantic data integration in MSE, offering a new approach for data-centric research and enhanced analytical capabilities.
Exploring post-COVID-19 health effects and features with advanced machine learning techniques
Authors: Islam Muhammad Nazrul , Islam Md Shofiqul , Shourav Nahid Hasan , Rahman Iftiaqur , Faisal Faiz Al , Islam Md Motaharul , Sarker Iqbal H. 
Published: April 2024

AbstractCOVID-19 is an infectious respiratory disease that has had a significant impact, resulting in a range of outcomes including recovery, continued health issues, and the loss of life. Among those who have recovered, many experience negative health effects, particularly influenced by demographic factors such as gender and age, as well as physiological and neurological factors like sleep patterns, emotional states, anxiety, and memory. This research aims to explore various health factors affecting different demographic profiles and establish significant correlations among physiological and neurological factors in the post-COVID-19 state. To achieve these objectives, we have identified the post-COVID-19 health factors and based on these factors survey data were collected from COVID-recovered patients in Bangladesh. Employing diverse machine learning algorithms, we utilised the best prediction model for post-COVID-19 factors. Initial findings from statistical analysis were further validated using Chi-square to demonstrate significant relationships among these elements. Additionally, Pearson’s coefficient was utilized to indicate positive or negative associations among various physiological and neurological factors in the post-COVID-19 state. Finally, we determined the most effective machine learning model and identified key features using analytical methods such as the Gini Index, Feature Coefficients, Information Gain, and SHAP Value Assessment. And found that the Decision Tree model excelled in identifying crucial features while predicting the extent of post-COVID-19 impact.
Degradation of edible mushroom waste by Hermetia illucens L. and consequent adaptation of its gut microbiota
Authors: Lai Linhui , Long Yaohang , Luo Meng , Tu Bo , Wu Zailin , Liu Jinling , Wan Zhixian , Wang Guangyin , Wang Xianyi , Liu Hongmei 
Published: April 2024

AbstractThe edible fungus industry is one of the pillar industries in the Yunnan–Guizhou Plateau, China. The expansion of the planting scale has led to the release of various mushroom residues, such as mushroom feet, and other wastes, which are not treated adequately, resulting in environmental pollution. This study investigated the ability of black soldier fly (Hermetia illucens L.) larvae (BSFL) to degrade mushroom waste. Moreover, this study analyzed changes in the intestinal bacterial community and gene expression of BSFL after feeding on mushroom waste. Under identical feeding conditions, the remaining amount of mushroom waste in Pleurotus ostreatus treatment group was reduced by 18.66%, whereas that in Flammulina velutipes treatment group was increased by 31.08%. Regarding gut microbial diversity, compared with wheat bran-treated control group, Dysgonomonas, Providencia, Enterococcus, Pseudochrobactrum, Actinomyces, Morganella, Ochrobactrum, Raoultella, and Ignatzschineria were the most abundant bacteria in the midgut of BSFL in F. velutipes treatment group. Furthermore, Dysgonomonas, Campylobacter, Providencia, Ignatzschineria, Actinomyces, Enterococcus, Morganella, Raoultella, and Pseudochrobactrum were the most abundant bacteria in the midgut of BSFL in P. ostreatus treatment group. Compared with wheat bran-treated control group, 501 upregulated and 285 downregulated genes were identified in F. velutipes treatment group, whereas 211 upregulated and 43 downregulated genes were identified in P. ostreatus treatment group. Using Kyoto Encyclopedia of Genes and Genomes and Gene Ontology enrichment analyses, we identified 14 differentially expressed genes (DEGs) related to amino sugar and nucleotide sugar metabolism in F. velutipes treatment group, followed by 12 DEGs related to protein digestion and absorption. Moreover, in P. ostreatus treatment group, two DEGs were detected for fructose and mannose metabolism, and two were noted for fatty acid metabolism. These results indicate that feeding on edible mushroom waste can alter the intestinal microbial community structure of BSFL; moreover, the larval intestine can generate a corresponding feedback. These changes contribute to the degradation of edible mushroom waste by BSFL and provide a reference for treating edible mushroom waste using BSFL.
Effects of lethal management on gray wolf pack persistence and reproduction in Wisconsin, USA
Authors: Zubiria Perez Alejandra , Kellner Kenneth F. , MacFarland David M. , Price Tack Jennifer L. , Ruid David B. , Stauffer Glenn E. , Belant Jerrold L. 
Published: April 2024

AbstractDirect human-caused mortality accounts for about half of all large mammal mortality in North America. For social species like gray wolves (Canis lupus), the death of pack members can disrupt pack structure and cause pack dissolution, and mortality of breeding adults or wolves during reproduction and pup-rearing can decrease pup recruitment. We estimated minimum and maximum probability of wolf pack persistence in Wisconsin, USA, during biological years (15 April–14 April) 2011–2019 and evaluated the influence of pack size and legal harvest mortality on pack persistence during 2012–2014. Harvests comprised 75–161 mortalities within 194 monitored packs during 2012–2014, with 56–74% of packs having no wolves harvested each year. As an index of reproduction during 2013–2019, we also estimated the proportion of packs where pups responded to howl surveys. We evaluated the influence of pack size, legal harvest, and agency removal on reproduction during 2013–2015. Annual maximum pack persistence probability was uniformly high (0.95–1.00), and annual minimum pack persistence probability ranged from 0.86–0.98 with a possible decline during years of harvest. Reproduction was similar in years following harvest and agency removal (2013–2015, pup response = 0.27–0.40), and years without harvest or agency removal the year prior (2016–2019, pup response = 0.28–0.66). Pack size had a positive effect on pack persistence and reproduction. Total number of wolf mortalities and number of adult male and females removed did not influence pack persistence or reproduction. We suggest that low per-pack mortality, timing of harvest and agency removal, and harvest characteristics during 2012–2014 supported stable pack persistence and reproduction.
An insight, at the atomic level, into the structure and catalytic properties of the isomers of the Cu22 cluster
Authors: Zhou Huimin , Yang Tao , Deng Huijuan , Yun Yapei , Jin Shan , Xiong Lin , Zhu Manzhou 
Published: April 2024

The structural isomers of Cu22 exhibit significant differences in the copper-catalyzed [3 + 2] azide-alkyne cycloaddition reaction (CuAAC), which offers a valuable opportunity to investigate the structure-function relationship of copper nanoclusters.
PL-hMSC and CH-hMSC derived soluble factors inhibit proliferation but improve hGBM cell migration by activating TGF-β and inhibiting Wnt signaling
Authors: Uthanaphun Tanawat , Manochantr Sirikul , Tantrawatpan Chairat , Tantikanlayaporn Duangrat , Kheolamai Pakpoom 
Published: April 2024

Abstract
Glioblastoma multiforme (GBM) is one of the most common and aggressive brain tumors. GBM resists most chemotherapeutic agents, resulting in a high mortality rate in patients. Human mesenchymal stem cells (hMSCs), which are parts of the cancer stroma, have been shown to be involved in the development and progression of GBM. However, different sources of hMSCs might affect GBM cells differently. In the present study, we established hMSCs from placenta (PL-hMSC) and chorion (CH-hMSC) to study the effects of their released soluble factors on the proliferation, migration, invasion, gene expression, and survival of human GBM cells, U251. We found that the soluble factors derived from CH-hMSCs and PL-hMSCs suppressed the proliferation of U251 cells in a dose-dependent manner. In contrast, soluble factors derived from both hMSC sources increased U251 migration without affecting their invasive property. The soluble factors derived from these hMSCs decreased the expression levels of CyclinD1, E2Fs and MYC genes that promote GBM cell proliferation but increased the expression level of TWIST gene, which promotes EMT and GBM cell migration. The functional study suggests that both hMSCs might exert their effects, at least in part, by activating TGF-β and suppressing Wnt/β-catenin signaling in U251 cells. Our study provides a better understanding of the interaction between GBM cells and gestational tissue-derived hMSCs. This knowledge might be used to develop safer and more effective stem cell therapy that improves the survival and quality of life of patients with GBM by manipulating the interaction between hMSCs and GBM cells.
Multi-wavelength pulse profiles from the force-free neutron star magnetosphere
Authors: Pétri J. 
Published: April 2024

Context. The last two decades have witnessed dramatic progress in our understanding of neutron star magnetospheres thanks to force-free and particle-in-cell simulations. However, the associated particle dynamics and its emission mechanisms and locations have not been fully constrained, notably in X-rays.
Aims. In this paper, we compute a full atlas of radio, X-ray, and γ-ray pulse profiles, relying on the force-free magnetosphere model. Our goal is to use such a data bank of multi-wavelength profiles to fit a substantial number of radio-loud γ-ray pulsars that have also been detected in non-thermal X-rays to decipher the X-ray radiation mechanism and sites. Using results from the third γ-ray pulsar catalogue (3PC), we investigate the statistical properties of this population.
Methods. We assume that radio emission emanates from field lines rooted to the polar caps, at varying height above the surface, close to the surface, at an altitude about 5–10% of the light cylinder radius, r L. The X-ray photons are produced in the separatrix region within the magnetosphere; that is, the current sheet formed by the jump from closed to open magnetic field lines. We allow for substantial variations in emission height. The γ-rays are produced within the current sheet of the striped wind, outside the light cylinder.
Results. A comprehensive set of radio, X-ray, and γ-ray light curves was computed. Based on only geometric considerations about magnetic obliquity, line-of-sight inclination, and the radio beam cone opening angle, pulsars can be classified as radio-loud or quiet and as γ-ray-loud or quiet. We found that the 3PC sample is compatible with an isotropic distribution of obliquity and line of sight.
Conclusions. The atlases constructed in this work are the fundamental tools with which to explore individual pulsars and fit their multi-wavelength pulse profiles in order to constrain their magnetic topology, the emission sites, and the observer’s line of sight.
The spin, expansion, and contraction of open star clusters
Authors: Jadhav Vikrant V. , Kroupa Pavel , Wu Wenjie , Pflamm-Altenburg Jan , Thies Ingo 
Published: April 2024

Context. Empirical constraints on the internal dynamics of open clusters are important for understanding their evolution and evaporation. High-precision astrometry from Gaia DR3 is thus useful to observe aspects of the cluster dynamics.
Aims. This work aims to identify dynamically peculiar clusters such as spinning and expanding clusters. We also quantify the spin frequency and expansion rate and compare them with N-body models to identify the origins of the peculiarities.
Methods. We used the latest Gaia DR3 and archival spectroscopic surveys to analyse the radial velocities and proper motions of the cluster members in 1379 open clusters. A systematic analysis of synthetic clusters was performed to demonstrate the observability of the cluster spin along with effects of observational uncertainties. N-body simulations were used to understand the evolution of cluster spin and expansion for initially non-rotating clusters.
Results. We identified spin signatures in ten clusters (and 16 candidates). Additionally, we detected expansion in 18 clusters and contraction in three clusters. The expansion rate is compatible with previous theoretical estimates based on the expulsion of residual gas. The orientation of the spin axis is independent of the orbital angular momentum.
Conclusions. The spin frequencies are much larger than what was expected from simulated, initially non-rotating clusters. This indicates that > 1% of the clusters are born rotating and/or they have undergone strong interactions. Higher precision observations are required to increase the sample of such dynamically peculiar clusters and to characterise them.