bluuebunny/crossref_metadata_2025_split huggingface dataset:
Administration of 6‐gingerol greatly enhances the number of tumor‐infiltrating lymphocytes in murine tumors
Authors: Ju Seong‐A , Park Sang‐Min , Lee Yea‐Sol , Bae Jun‐Hyeong , Yu Rina , An Won G. , Suh Jae‐Hee , Kim Byung‐Sam 
Published: July 2011

AbstractTumor‐infiltrating lymphocytes (TILs) play critical roles in host antitumor immune responses. It is known that cancer patients with tumor‐reactive lymphocyte infiltration in their tumors have better prognoses, while patients with tumors infiltrated by immunosuppressive cells have worse prognoses. We found that administration of 6‐gingerol, which is a component of ginger, inhibited tumor growth in several types of murine tumors, such as B16F1 melanomas, Renca renal cell carcinomas and CT26 colon carcinomas, which were established by inoculating tumor cells on the flanks of mice. However, administration of 6‐gingerol did not lead to complete eradication of the tumors. 6‐Gingerol treatment of tumor‐bearing mice caused massive infiltration of CD4 and CD8 T‐cells and B220+ B‐cells, but reduced the number of CD4+Foxp3+ regulatory T‐cells. The CD8 tumor‐infiltrating T lymphocytes in 6‐gingerol‐treated mice strongly expressed IFN‐γ, a marker of activation of cytotoxic T lymphocytes (CTL) CD107a and chemokine receptors that are expressed on TH1 cells, such as CXCR3 and CCR5. To test whether 6‐gingerol could promote infiltration of tumor antigen‐specific CD8 T‐cells into tumors, we adoptively transferred CFSE‐labeled OT‐1 CD8 T‐cells into EG7 tumor‐bearing mice. We found that CD8 T cells isolated from 6‐gingerol pretreated OT‐1 mice, but not from control OT‐1 mice, massively infiltrated tumors and tumor draining lymph nodes and divided several times. Our results strongly suggest that 6‐gingerol can be used in tumor immunotherapy to increase the number of TILs.
The distributed diagonal force decomposition method for parallelizing molecular dynamics simulations
Authors: Borštnik Urban , Miller Benjamin T. , Brooks Bernard R. , Janežič Dušanka 
Published: July 2011

AbstractParallelization is an effective way to reduce the computational time needed for molecular dynamics simulations. We describe a new parallelization method, the distributed‐diagonal force decomposition method, with which we extend and improve the existing force decomposition methods. Our new method requires less data communication during molecular dynamics simulations than replicated data and current force decomposition methods, increasing the parallel efficiency. It also dynamically load‐balances the processors' computational load throughout the simulation. The method is readily implemented in existing molecular dynamics codes and it has been incorporated into the CHARMM program, allowing its immediate use in conjunction with the many molecular dynamics simulation techniques that are already present in the program. We also present the design of the Force Decomposition Machine, a cluster of personal computers and networks that is tailored to running molecular dynamics simulations using the distributed diagonal force decomposition method. The design is expandable and provides various degrees of fault resilience. This approach is easily adaptable to computers with Graphics Processing Units because it is independent of the processor type being used. © 2011 Wiley Periodicals, Inc. J Comput Chem, 2011
Theoretical study on the molecular structures of X‐, α‐, and β‐types of lithium phthalocyanine dimer
Authors: Sumimoto Michinori , Kawashima Yukio , Yokogawa Daisuke , Hori Kenji , Fujimoto Hitoshi 
Published: July 2011

AbstractWe report here the results from theoretical calculations of the potential energy curves, the geometry optimizations, and the electronic structures for three dimers of lithium phthalocyanine (LiPc) by using three types of functional systems: PBE1PBE, B3LYP, and M06. The results were discussed in comparison with those obtained for the dimers of magnesium phthalocyanine (MgPc). The long‐range dispersive interactions were considered in part using these functional systems in the increasing order of PBE1PBE, B3LYP, and M06. The mechanism whereby the dispersive interactions affect the geometric and electronic structures of the LiPc and MgPc dimers is discussed. The calculated results provide insight into the computational methods for both open‐ and closed‐shell metal phthalocyanine (MPc) dimers: Although the PBE1PBE and B3LYP functional systems cannot evaluate a weak dispersion interaction appropriately, the M06 functional can estimate a weak dispersion interaction well in both open‐ and closed‐shell MPc dimers. Basis set superposition error (BSSE) corrections play an important role for the quantitative analysis; however, the calculation results without BSSE corrections may be sufficient for the qualitative discussion on the properties of these dimers such as geometries, stabilities, electronic structures, and so on. © 2011 Wiley Periodicals, Inc. J Comput Chem, 2011
The OB hospitalist and the risk manager: Ready for prime time
Authors: Veltman Larry 
Published: July 2011

AbstractIn 1996, Wachter and Goldman described a new model of care in which hospital‐based physicians provided patients' inpatient care in lieu of the patient’s primary physician.(1) They termed these physicians hospitalists. The hospitalist movement had taken hold, and by 1999, 65% of internists had hospitalists in their community and 28% reported using them for inpatient care.(2) In 2003, Louis Weinstein, in an article entitled “The Laborist: A New Focus of Practice for the Obstetrician”(3) advocated for the adoption of the hospitalist model to obstetrical care. In a 2010 study, of 28,545 members of the American College of Obstetricians and Gynecologists (ACOG) contacted in a national survey, 7,044 clinicians responded, which yielded a response rate of 25%. Of the respondents, 1,020 clinicians (15% of respondents, 3.6% of the entire sample) described themselves as obstetrics/gynecology hospitalists or laborists.(4) According to the web site www.obgynhospitalist.com, there are at least 115 hospitals in the country that utilize a laborist or OB hospitalist model of care.(5).
The Importance of Applied Research in Investigative Interviewing: A Real‐life Perspective
Authors: Oxburgh Gavin E. , Walsh Dave , Milne Becky 
Published: July 2011

AbstractThe papers contained within the special issue represent some exciting innovations across different investigative bodies. In addition, all research presented has been conducted in the field. It is believed that such applied research, although often having methodological drawbacks, is of utmost importance in understanding the area from a holistic viewpoint. This special issue examines the role forensic psychology has had and is currently having in investigative interviewing in the real world. Copyright © 2011 John Wiley & Sons, Ltd.
An investigation of paint from a mural in the church of Sainte Madeleine, Manas, France
Authors: March Raymond E. , Papanastasiou Malvina , McMahon Adam W. , Allen Norman S. 
Published: July 2011

AbstractThe pigment in brown paint samples taken from a church in the Drôme region of France has been shown to be almost pure 6‐bromoindigo and 6,6′‐dibromoindigo. The composition of the pigment was established by comparison with 6‐bromoindigo and 6,6′‐dibromoindigo standards using atmospheric pressure photoionization combined with liquid chromatography and tandem mass spectrometry. The brown paint samples were taken from a frieze of ca 20 brown images having symmetric tree‐like forms composed of five overlapping filled circles representing foliage. The tree‐like images, simple rather than artistic, had a metallic luster. The molar ratio of 6‐bromoindigo and 6,6′‐dibromoindigo in the brown paint pigment (98:2) is remarkably similar to that of shellfish purple from the Mediterranean Murex brandaris (96.5:3.5) thus, it is possible that the origin of the indigoid compounds in the brown paint pigment is the eastern coast of the Mediterranean Sea. As the production of Tyrian purple ended with the fall of Byzantium in 1453, purple pigment had to have been produced prior to this time. We have conjectured about the circumstances that may account for the use of ‘purple’ in this manner in the Drôme region and how the pigment was transported there from the eastern coast of the Mediterranean Sea during the time of the Crusades. Copyright © 2011 John Wiley & Sons, Ltd.
Parametric macromodeling based on amplitude and frequency scaled systems with guaranteed passivity
Authors: Ferranti Francesco , Knockaert Luc , Dhaene Tom , Antonini Giulio 
Published: July 2011

SUMMARYWe propose a novel parametric macromodeling method for systems described by scattering parameters, which depend on multiple design variables such as geometrical layout or substrate features. It is able to build accurate multivariate macromodels that are stable and passive over the entire design space. Poles and residues are parameterized indirectly. The proposed method is based on an efficient and reliable combination of rational identification, a procedure to find amplitude and frequency scaling system coefficients and positive interpolation schemes. Pertinent numerical examples validate the proposed parametric macromodeling technique. Copyright © 2011 John Wiley & Sons, Ltd.
Do paleoclimate proxies agree? A test comparing 19 late Holocene climate and sea‐ice reconstructions from Icelandic marine and lake sediments
Authors: Axford Yarrow , Andresen Camilla S. , Andrews John T. , Belt Simon T. , Geirsdóttir Áslaug , Massé Guillaume , Miller Gifford H. , Ólafsdóttir Sædís , Vare Lindsay L. 
Published: July 2011

AbstractGeochemical, mineralogical and biological indicators preserved in sediments are widely used to reconstruct past climate change, but proxies differ in the degree to which their utility as climate indicators has been validated via laboratory experiments, modern spatial calibrations, or down‐core comparisons with instrumental climate data. Multi‐proxy studies provide another means of evaluating interpretations of proxies. This paper presents a multi‐proxy assessment comparing 19 sub‐centennially resolved late Holocene proxy records, covering the period 300–1900 AD, from seven Icelandic marine and lacustrine core sites. We employ simple statistical comparisons between proxy reconstructions to evaluate their correlations over time and, ultimately, their utility as proxies for regional climate. Proxies examined include oxygen isotopic composition of benthic and planktonic foraminifera, abundance of the sea‐ice biomarker IP25, allochthonous quartz in marine sediments (a proxy for drift ice around Iceland), marine carbonate abundance, total organic carbon concentration, chironomid assemblages, lacustrine biogenic silica and carbon/nitrogen ratios in lake sediments. Most of the examined proxy records, including temperature and sea‐ice proxies, correlate strongly with each other over multi‐centennial timescales, and thus do appear to record changes in regional climate. Copyright © 2011 John Wiley & Sons, Ltd.
Vulture flight behavior and implications for aircraft safety
Authors: Avery Michael L. , Humphrey John S. , Daughtery Trey S. , Fischer Justin W. , Milleson Michael P. , Tillman Eric A. , Bruce William E. , Walter W. David 
Published: July 2011

AbstractGrowing vulture populations represent increasing hazards to civil and military aircraft. To assess vulture flight behavior and activity patterns at the Marine Corps Air Station in Beaufort, South Carolina, we equipped 11 black vultures (Coragyps atratus) and 11 turkey vultures (Cathartes aura) with solar‐powered Global Positioning System (GPS) satellite transmitters during a 2‐year study (1 Oct 2006–30 Sep 2008). Turkey vultures had larger seasonal home ranges than did black vultures, and 2 turkey vultures made round‐trips to Florida. Black vultures consistently spent less time in flight (8.4%) than did turkey vultures (18.9%), and black vultures flew at higher altitudes than did turkey vultures in all seasons except summer when altitudinal distributions (above ground level) did not differ. Although we recorded maximum altitudes of 1,578 m for black vultures and 1,378 for turkey vultures, most flights were low altitude. A matrix of vulture flight altitude versus time of day revealed that >60% of vulture flight activity occurred from 4 hr to 9 hr after sunrise at altitudes below 200 m. Continuation of aggressive harassment coupled with flexible training schedules to avoid times and altitudes of high vulture activity will decrease hazards to aircraft posed by these birds. © 2011 The Wildlife Society.
Cluster analysis of auditory and vestibular test results in definite menière's disease
Authors: Montes‐Jovellar Lourdes , Guillen‐Grima Francisco , Perez‐Fernandez Nicolas 
Published: July 2011

AbstractObjectives/Hypothesis:To determine whether patients with Menière's disease can be grouped into distinct subtypes based on a cluster analysis of distinct disease parameters.Study Design:Prospective study at a tertiary center associated with a university hospital.Methods:The study included 153 patients diagnosed with unilateral definite Menière's disease. The main variables employed were taken from auditory, vestibular, posturographic, and disability assessments.Results:A four‐cluster solution best fitted the data. Each cluster represented a distinct patient profile. Cluster 1 patients (13.1%) were the eldest, with the worst hearing bilaterally and good vestibular function but with a significant postural impact and a low level of disability. Cluster 2 patients (41.2%) were the least affected in all the parameters that were close to normal. Cluster 3 patients (34.6%) were the most affected, experiencing frequent and intense vertigo attacks, and they were visually dependent. Cluster 4 patients (11.1%) had strong asymmetric hearing between both ears and the most uncompensated vestibular deficit; they were moderately disabled.Conclusions:We have identified four distinct profiles of patients with definite Menière's disease that we consider as “mildly active elderly,” “mildly active young,” “active compensated,” and “active uncompensated.” We have demonstrated that only in a restricted population of patients can the American Academy of Otolaryngology–Head and Neck Surgery staging system provide analysis of subtypes of the disease.
Effect of Compatibilizer Concentration on Rheological Behavior, Morphologies, and Mechanical Properties of PVDF/TPU Blends
Authors: Ma Haiying , Xiong Zhengrong , Lv Fengxian , Li Chan , Yang Yuming 
Published: July 2011

AbstractThe rheological behavior, morphologies, and tensile properties of reactively compatibilized PVDF/TPU blends are reported. Using PVDF‐g‐AAc as the compatibilizer, PVDF/TPU 90/10 and 10/90 blends are prepared. The carboxylic acid groups of PVDF‐g‐AAc react with the urethane linkages of TPU during melt blending to generate in situ PVDF‐g‐AAc‐g‐TPU which leads to compatibilization of PVDF/TPU blends. The introduction of PVDF‐g‐AAc into the PVDF/TPU blends causes an increase in viscosity. The rheological behavior of the compatibilized PVDF/TPU 90/10 and 10/90 blends are well described by the generalized Zener model. The addition of the compatibilizer PVDF‐g‐AAc reduces the dispersed‐phase domain size and narrows the size distribution. ▪Author: The summary has been shortened to comply with the maximum of 700 characters. Pls check/confirm changes!▪magnified image
Flow‐Induced Morphology of iPP Solidified in a Shear Device
Authors: Pantani Roberto , Balzano Luigi , Peters Gerrit W. M. 
Published: July 2011

AbstractThe morphology of molded parts is the result of a competition between deformation rate, crystallization kinetics, relaxation times, and cooling. In this work, samples are solidified isothermally, so that the differences in morphology can be ascribed only to flow, and after a step shear, so that the effect of crystallinity on flow can be neglected. The resulting morphology is characterized, so that the data can be adopted for any further analysis. A comparison is conducted among the resulting structures and an attempt is made to identify a key parameter able to justify the differences. It is found that the main morphological features can be correlated to a single rheological parameter: the maximum attained value of molecular strain during the pulse of flow.magnified image
Quasiminimality in mixed Tsirelson spaces
Authors: Manoussakis Antonis , Pelczar Anna Maria 
Published: July 2011

AbstractWe prove quasiminimality of regular the mixed Tsirelson spaces \documentclass{article}\usepackage{amssymb}\begin{document}\pagestyle{empty}$T[(\mathcal {S}_{n},\theta _{n})_{n}]$\end{document} with the sequence \documentclass{article}\usepackage{amssymb}\begin{document}\pagestyle{empty}$\big (\frac{\theta _n}{\theta ^n}\big )_n$\end{document} decreasing, where θ = limnθ1/nn, and quasiminimality of all mixed Tsirelson spaces \documentclass{article}\usepackage{amssymb}\begin{document}\pagestyle{empty}$T[(\mathcal {A}_{n},\theta _{n})_{n}]$\end{document}. We prove that under certain assumptions on the sequence (θn)n the dual spaces are quasiminimal.
Hospitalization for invasive pneumococcal disease in a national sample of children with sickle cell disease before and after PCV7 licensure
Authors: McCavit Timothy L. , Xuan Lei , Zhang Song , Flores Glenn , Quinn Charles T. 
Published: July 2011

AbstractObjectiveTo estimate national hospitalization rates for invasive pneumococcal disease (IPD) in children with sickle cell disease (SCD) before and after the 2000 licensure of the heptavalent pneumococcal conjugate vaccine (PCV7).ProcedureWe performed a retrospective trend analysis of the 1994–2007 Nationwide Inpatient Sample databases. Hospitalizations involving children with SCD and IPD were identified by ICD‐9CM code. The primary outcomes, the annual hospitalization rate for IPD in children with SCD and the proportion of hospitalizations for IPD per 100 total SCD hospitalizations, were analyzed using multivariable linear regression and contingency analysis, respectively.ResultsA total of 1,242 hospitalizations for IPD in SCD patients were identified from 1994–2007, with a mortality rate of 2.4%. The national mean annual rate of IPD hospitalization decreased by 65%, from 131.8 cases/year from 1994 to 2000 to 45.5 cases/year from 2001 to 2007 (P = 0.001). The national proportion of hospitalizations for IPD per 100 total SCD hospitalizations decreased from 0.4 to 0.15 (P < 0.0001) over the same interval. Following PCV7 licensure, the mean annual cumulative hospital days and cumulative hospital charges decreased nationally by 53% and 36%, respectively.ConclusionIn a national sample, PCV7 licensure is temporally associated with a nearly threefold reduction in IPD hospitalizations in children with SCD. Pediatr Blood Cancer 2012; 58: 945–949. © 2011 Wiley Periodicals, Inc.
One‐component benzoxazine type photoinitiator for free radical polymerization
Authors: Temel Gokhan , Esen Duygu Sevinc , Arsu Nergis 
Published: July 2011

AbstractSynthesis of the Benzoxazine based benzophenone (BPBnzx) initiator was achieved and used in free radical photopolymerization of methylmethacrylate (MMA) in the absence and presence of a tertiary amine. The results confirmed that BPBnzx presents a one‐component nature. BPBnzx has better absorption properties compared with BP itself and the one‐component characteristic of the BPBnzx initiator was confirmed by incorporation of the BPBnzx unit into the polymethylmethacrylate (PMMA) main chain, using UV spectroscopy and phosphorescence measurements. POLYM. ENG. SCI., 2012. © 2011 Society of Plastics Engineers
Synthesis of poly(quinoxaline‐2,3‐diyl)s with alkoxy side chains by aromatizing polymerization of 4,5‐dialkoxy‐substituted 1,2‐ diisocyanobenzenes
Authors: Nagata Yuuya , Suginome Michinori 
Published: July 2011

AbstractPoly(quinoxaline‐2,3‐diyl)s bearing alkoxy pendants was synthesized by living polymerization of 4,5‐dialkoxy‐3,6‐dimethyl‐1,2‐diisocyanobenzenes, which were easily accessible from 3,6‐dimethylcatechol, using organonickel complexes as initiators. Thermal properties of the obtained polymers were fully determined by thermogravimetric analysis and differential scanning calorimetry, exhibiting strong dependence on their side chains. © 2011 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2011
The evolution of function in strictosidine synthase‐like proteins
Authors: Hicks Michael A. , Barber Alan E. , Giddings Lesley‐Ann , Caldwell Jenna , O'Connor Sarah E. , Babbitt Patricia C. 
Published: July 2011

AbstractThe exponential growth of sequence data provides abundant information for the discovery of new enzyme reactions. Correctly annotating the functions of highly diverse proteins can be difficult, however, hindering use of this information. Global analysis of large superfamilies of related proteins is a powerful strategy for understanding the evolution of reactions by identifying catalytic commonalities and differences in reaction and substrate specificity, even when only a few members have been biochemically or structurally characterized. A comparison of >2500 sequences sharing the six‐bladed β‐propeller fold establishes sequence, structural, and functional links among the three subgroups of the functionally diverse N6P superfamily: the arylesterase‐like and senescence marker protein‐30/gluconolactonase/luciferin‐regenerating enzyme‐like (SGL) subgroups, representing enzymes that catalyze lactonase and related hydrolytic reactions, and the so‐called strictosidine synthase‐like (SSL) subgroup. Metal‐coordinating residues were identified as broadly conserved in the active sites of all three subgroups except for a few proteins from the SSL subgroup, which have been experimentally determined to catalyze the quite different strictosidine synthase (SS) reaction, a metal‐independent condensation reaction. Despite these differences, comparison of conserved catalytic features of the arylesterase‐like and SGL enzymes with the SSs identified similar structural and mechanistic attributes between the hydrolytic reactions catalyzed by the former and the condensation reaction catalyzed by SS. The results also suggest that despite their annotations, the great majority of these >500 SSL sequences do not catalyze the SS reaction; rather, they likely catalyze hydrolytic reactions typical of the other two subgroups instead. This prediction was confirmed experimentally for one of these proteins. Proteins 2011;. © 2011 Wiley‐Liss, Inc.
Theoretical study on HO2‐initiated atmospheric oxidation of halogenated carbonyls
Authors: Long Bo , Long Zheng‐Wen , Wang Yi‐Bo , Zhang Wei‐Jun , Long Chao‐Yun , Qin Shui‐Jie 
Published: July 2011

AbstractThe initial reactions of HO2with oxalyl dichloride, oxalyl dibromide, acetyl chloride, and acetyl bromide are studied for the first time using the density functional theory with CAM‐B3LYP and wB97XD, CBS‐QB3, and G3 theoretical methods and the transition state theory. The reactions occur via the similar mechanism that the prereactive complex is formed before the transition state and product. The calculated results demonstrate that the HO2radical with ClC(O)C(O)Cl and BrC(O)C(O)Br reactions is feasible and could play a significant role in the atmosphere because the barriers are 0.13 kcal/mol, −0.05 kcal/mol with respect to the free reactants, respectively at the CBS‐QB3 level of theory. In addition, the rate constants of the HO2+ ClC(O)C(O)Cl and HO2+ BrC(O)C(O)Br reactions are computed to be 1.37 × 10−15cm3mol−1s−1, 1.70 × 10−15cm3mol−1s−1at 298 K. However, the HO2reactions with acetyl chloride and acetyl bromide are of no importance because of higher activated barrier and slower rate constant. © 2011 Wiley Periodicals, Inc. Int J Quantum Chem, 2011