bluuebunny/crossref_metadata_2025_split huggingface dataset:
A case report of Hyper‐IgD syndrome in a 5‐year‐old girl with recurrent fever, skin rash, and arthralgia; novel MVK mutation (C.298G>A)
Authors: Tabibi Pooneh , Shiari Reza , Ghotb Abadi Shabnam Hajiani 
Published: April 2024

Key Clinical MessageThis case highlights the potential for later‐onset Hyper‐IgD syndrome (HIDS) even beyond infancy. Clinicians evaluating children with recurrent fever, skin rash, and arthralgia should consider HIDS in the differential diagnosis, regardless of age. Early suspicion and genetic testing can lead to a timely diagnosis and targeted therapy with Anakinra, significantly improving patient outcomes.AbstractHyper‐IgD syndrome (HIDS) is a rare autosomal recessive autoinflammatory disorder characterized by recurrent episodes of fever, lymphadenopathy, arthralgia, diarrhea, abdominal pain, and skin rash. In this case report, we present a 5‐year‐old girl from Tajikistan with a mutation in the mevalonate kinase (MVK) gene, which is consistent with a diagnosis of HIDS. The clinical symptoms of the patient are described, along with immunological, hematological, and biochemical findings collected from the evaluation in the rheumatology clinic. Additionally, whole‐exome sequencing revealed a heterozygous missense variation in exon 4 of the MVK gene. The diagnosis of HIDS in this case occurred at a later age than typically observed, emphasizing the importance of considering this condition even in older patients. This report highlights the broad clinical phenotype of MVK and the need for increased awareness among healthcare professionals regarding its clinical presentation and management.
Organic Acid‐Assisted Preparation of Hydroxyapatite‐Supported Ni Catalysts for Arene Hydrogenation
Authors: Duan Chengjie , Li Kun , Ye Wenbo , Mao Weitao , He Guangke , Liu Xiang 
Published: April 2024

AbstractDeveloping non‐noble metal catalysts that can efficiently and selectively hydrogenate arenes remains a significant challenge. In this study, we developed efficient Ni catalysts for the arene hydrogenation based on an organic acid‐regulated impregnation strategy. These easily accessible Ni catalysts demonstrated exceptional efficiency, selectivity, reusability, and good substrate compatibility. The influence of carbon chain lengths and side‐chain hydroxyl or amino groups on dicarboxylic acids used in the catalyst preparation was comprehensively investigated. Characterizations and kinetic studies demonstrated the influence of organic acids on the size of Ni nanoparticles, the proportion of metallic nickel, and the strength of surface acidity. These factors influenced the activation of arene and hydrogen, thereby affecting the hydrogenative activity. Notably, hydroxyapatite‐supported Ni catalyst, assisted by tartaric acid (Ni‐TA/HAP) with an appropriate tartaric acid‐to‐nickel ratio, resulted in relatively smaller Ni nanoparticles, an increased proportion of Ni0, and more acidic sites, thereby exhibiting the best hydrogenation performance.
Catechol‐Formaldehyde Resin Coated CdS Core‐Shell Composite as Robust Photocatalyst for Long‐Term Sustainable Artificial Photosynthesis of H2O2
Authors: Xiang Yuexin , Xia Zhinan , Hu Wanchao , Tong Cuiyan , Xiao Yang , Lü Changli 
Published: April 2024

Comprehensive SummaryCatechol‐formaldehyde resin (CFR) is very attractive for H2O2 production via the catalytic process. However, the H2O2 formation is accompanied by the oxidation of catechol groups to o‐benzoquinone groups on CFR, which will cause irreversible damage to CFR and greatly limit its long‐term stable catalytic activity. Herein, CdS/CFR composite photocatalyst with a core‐shell structure was synthesized by hydrothermal method. The photogenerated electrons of CdS are used as a powerful driving force for the reversible redox conversion between catechol groups and o‐benzoquinone groups on the CFR, which not only achieves the long‐term stability of CFR‐catalyzed production of H2O2, but also promotes the separation efficiency of photogenerated e– and h+ in CdS, greatly inhibiting their recombination, so as to maintain CdS stability. The H2O2 yield of CdS/CFR can accumulate to 1.65 mmol·L–1 under visible light for 6 h without sacrificial agent, which is about 3.1 and 2 times that of CdS and CFR, respectively, and CdS/CFR can persist for 10 cycles of photocatalysis (60 h). CdS/CFR also improves the yield of photocatalytic H2O2 by increasing the selectivity of H2O2 and inhibiting its decomposition. This work offers a novel tactic for expanding the application of CFR in photocatalytic generation of H2O2.
Copper/Photoredox‐Catalyzed Regioselective 1,4‐Addition to 1,3‐Enynes: A Convenient Access to Perfluoroalkylated Allenes
Authors: Chen Ya , Wanga Quanyuan , Penga Keyi , Chenga Lilei , Shea Ziyi , Deng Guo‐Jun 
Published: April 2024

Comprehensive SummaryA general and broadly applicable copper and photoredox dual‐catalyzed multicomponent 1,4‐perfluoroalkylcyanation of 1,3‐enynes has been developed. This protocol enjoys success with high regioselectivity, mild reaction conditions, and excellent functional‐group tolerance, allowing the facile synthesis of structurally diverse perfluoroalkylated allenes from readily available fluoroalkyl halides, 1,3‐enynes and TMSCN in a one‐pot manner. A reasonable mechanism has been proposed according to a series of control experiments.
Comparative anatomy of the caudate nucleus in canids and felids: Associations with brain size, curvature, cross‐sectional properties, and behavioral ecology
Authors: Foster Michael , Dwibhashyam Sai , Patel Devan , Gupta Kanika , Matz Olivia C. , Billings Brendon K. , Bitterman Kathleen , Bertelson Mads , Tang Cheuk Y. , Mars Rogier B. , Raghanti Mary Ann , Hof Patrick R. , Sherwood Chet C. , Manger Paul R. , Spocter Muhammad A. 
Published: April 2024

AbstractThe evolutionary history of canids and felids is marked by a deep time separation that has uniquely shaped their behavior and phenotype toward refined predatory abilities. The caudate nucleus is a subcortical brain structure associated with both motor control and cognitive, emotional, and executive functions. We used a combination of three‐dimensional imaging, allometric scaling, and structural analyses to compare the size and shape characteristics of the caudate nucleus. The sample consisted of MRI scan data obtained from six canid species (Canis lupus lupus, Canis latrans, Chrysocyon brachyurus, Lycaon pictus, Vulpes vulpes, Vulpes zerda), two canid subspecies (Canis lupus familiaris, Canis lupus dingo), as well as three felids (Panthera tigris, Panthera uncia, Felis silvestris catus). Results revealed marked conservation in the scaling and shape attributes of the caudate nucleus across species, with only slight deviations. We hypothesize that observed differences in caudate nucleus size and structure for the domestic canids are reflective of enhanced cognitive and emotional pathways that possibly emerged during domestication.
Providing a Review of Hot Carrier (HC) Relaxation Dynamics and Strategies of HC Extraction in Perovskites Nanocrystals
Authors: Marjit Kritiman , Das Antika , Ghosh Debarati , Patra Amitava 
Published: April 2024

AbstractMetal halide perovskite (MHPs) nanocrystals (NCs) have recently emerged as promising materials for optoelectronic applications due to their exceptional photophysical properties. A comprehensive understanding of the underlying principles and key challenges associated with controlling the hot carrier (HC) cooling dynamics in MHPs is pivotal for the design of efficient perovskite‐based optoelectronic applications. This review highlights the general carrier cooling mechanism and identifies influencing crucial controlling parameters for carrier dynamics. The discussion includes strategies for manipulating HC cooling dynamics through carrier‐phonon and carrier‐carrier interactions. Notably, recent advancements in HC extraction with suitable acceptors are explored, as efficient HC extraction is imperative for the advancement of optoelectronic applications. The objective of this review is to outline potential pathways for strategically modifying carrier cooling processes to align with specific optoelectronic applications. A profound comprehension of charge carrier dynamics in MHPs NCs will pave the way for the development of highly efficient optoelectronic applications.
Apixaban Pharmacokinetics and Bioequivalence of Two Tablet Formulations: A Randomized, Open‐Label, Crossover Study, Fasting Condition in Healthy Indonesian Volunteers
Authors: Leong Chuei Wuei , Yee Kar Ming , Liew Ivan , Khaleb Nur Athirah , Ahmad Shahnun , Rani Tracy Ann , Lau Kheng Jim , Yunaidi Danang Agung , Simanjuntak Ronal , Ginanjar Vicky A. 
Published: April 2024

AbstractThe present study aimed to assess the bioequivalence of a new apixaban generic with reference formulation. Twenty‐six healthy volunteers were recruited for an open‐label, balanced, randomized, 2‐treatment, 2‐sequence, 2‐period, single oral dose study. Following overnight fasting, each volunteer received 5 mg of apixaban test and reference formulations as single doses, separated by a 1‐week washout period. Twenty blood samples were collected at predose and multiple time points between 0.5 and 72 hours after dosing. A validated ultra‐performance liquid chromatography‐tandem mass spectrometry detection method following a protein precipitation step was implemented to determine apixaban concentrations. Noncompartmental analysis was used to derive the pharmacokinetic parameters, which were then compared between the test and reference products using a multivariate analysis of variance. The pharmacokinetic parameters of the test product were not statistically different from the reference product, and the 90% confidence intervals of apixaban natural log‐transformed area under the concentration‐time curve from time 0 to infinity, area under the concentration‐time curve from time 0 to the last measurable concentration, and maximum concentration were within 80%‐125% based on the bioequivalence acceptance range criteria. The test and reference formulations of apixaban are bioequivalent in healthy subjects under fasting conditions.
IPv6 addressing with hidden duplicate address detection to mitigate denial of service attacks in the internet of drone
Authors: Kumar Gyanendra , Pragya  
Published: April 2024

SummaryThe fusion of drones with the Internet, termed the Internet of Drones (IoD), resembles the Internet of Things (IoT) paradigm. In IoD, drones necessitate unique identifiers similar to IPv6 addresses. This paper presents a novel approach for securing the duplicate address detection (DAD) process in the IoD environment. This paper focuses on addressing the security challenges posed by malicious drones in the DAD process. The proposed solution introduces a hidden DAD (H‐DAD) process, to mitigate attacks on the DAD process. In this scheme, drones transmit a transformed portion of their interface identifier (IID) while concealing the full IID, thus thwarting potential disruptions by malicious entities. We evaluated the effectiveness of the H‐DAD scheme through experimental analysis using Python with SimPy, comparing it with the Improved DAD, Secure DAD, and Standard DAD schemes. Our results demonstrate a notable improvement, with the Hidden DAD scheme achieving a 100% address success rate under attack. Moreover, it exhibits approximately 5% and 12% lower overhead and energy consumption, respectively, compared to the other schemes.
Diphenylene Iodonium as a Prominent Halogen Bond Donor: The Case of Human Monoamine Oxidase B
Authors: Piña María de las Nieves , Bauzá Antonio 
Published: April 2024

AbstractHerein we have investigated the formation and interplay of several noncovalent interactions (NCIs) involved in the inhibition of human monoamine oxidase B (MAO B). Concretely, an inspection of the Protein Data Bank (PDB) revealed the formation of a halogen bond (HlgB) between a diphenylene iodonium (DPI) inhibitor and a water molecule present in the active site, in addition to a noncovalent network of interactions (e. g. lone pair‐π, hydrogen bonding, OH‐π, CH‐π and π‐stacking interactions) with surrounding protein residues. Several theoretical models were built to understand the strength and directionality features of the HlgB in addition to the interplay with other NCIs present in the active site of the enzyme. Besides, a computational study was carried out using DPI as HlgB donor and several electron rich molecules (CO, H2O, CH2O, HCN, pyridine, OCN−, SCN−, Cl− and Br−) as HlgB acceptors. The results were analyzed using several state‐of‐the‐art computational tools. We expect that our results will be useful for those scientists working in the fields of rational drug design, chemical biology as well as supramolecular chemistry.
Critical Aspects and Challenges in the Design of Small Molecules for Electrochemiluminescence (ECL) Application
Authors: Alberoni Chiara , Pavan Giulio , Scattolin Thomas , Aliprandi Alessandro 
Published: April 2024

AbstractElectrochemiluminescence (ECL) has gained renewed interest due to the strong parallel development of luminophores in the field of organic light emitting diodes (OLEDs) with which this technique shares several aspects. In this perspective review we discuss the most relevant advances of the past 15 years in the study of organic and organometallic compounds as ECL emitters, by dividing them in three different classes: i) fluorescent emitters, ii) phosphorescent emitters and iii) Thermally Activated Delayed Fluorescence (TADF) emitters; then, water‐soluble organic luminophores will be also discussed. We focus on how their design, their photo‐ and electrochemical properties and, in particular, the nature of the emitter, affect their efficiency in ECL. Regardless of the type of luminophore or the photoluminescence quantum yield (PLQY), the literature converges on the fact that the most determining aspect is the stability of the oxidized/reduced form of the emitter. Even if phosphorescent emitters can show outstanding efficiency, this often requires the absence of oxygen. In the case of TADFs, there is also a strong dependence of photoluminescence both in terms of PLQY and emission energy on the polarity of the media, so compounds, that appear promising in organic solvents, may be very inefficient in aqueous media.
The Role of Attentional Control in Mindfulness Intervention for Emotional Distress: A Randomized Controlled Trial With Longitudinal Mediation Analyses
Authors: Wang Zhenzhen , Shalihaer Kaerqika , Hofmann Stefan G. , Feng Shixing , Liu Xinghua 
Published: April 2024

ABSTRACTObjectiveThis study aimed to investigate whether attentional control serves as a mediator for mindfulness‐based interventions for emotional distress, utilizing a randomized waitlist (WL)‐controlled design.MethodsA total of 498 participants with high emotional distress was recruited online and randomly assigned to a 49‐day online Mindfulness Intervention for Emotional Distress (MIED) group (N = 249) or a WL control group (N = 249). Levels of attentional control, anxiety and depression were assessed at baseline (T0), Week 3 (T3), Week 5 (T5) and Week 7 (postintervention, T7).ResultsLinear mixed models revealed significant Group‐by‐Time interaction effects for attentional control (p < 0.001), anxiety (p < 0.001) and depression (p < 0.05). Latent growth curve analyses demonstrated a significant increase in attentional control and a decrease in anxiety and depression levels during the MIED programme. These changes becoming evident starting Week 3. Longitudinal mediation analyses revealed that the slope of attentional control significantly mediated the effects of the MIED programme on the slope of anxiety and depression levels. Further, attentional control level at Week 3 significantly mediates the effect of MIED programme on anxiety and depression levels at Weeks 5 and 7. Similarly, attentional control level at Week 5 significantly mediates the MIED programme's effects on anxiety and depression levels at Week 7.ConclusionsThe present trial provides evidence suggesting that mindfulness interventions may alleviate emotional distress through the enhancement of attentional control.Trial RegistrationChinese Clinical Trial Registry number: ChiCTR2200064140
Fusion of Cyclohepta[def]fluorene Units: Toward Synthesis of High‐Spin Non‐Benzenoid Nanographenes
Authors: Wu Fupeng , Fu Yubin , Niu Wenhui , Liu Fupin , Liu Renxiang , Qiu Zhenlin , Popov Alexey A. , Liu Junzhi , Ma Ji , Feng Xinliang 
Published: April 2024

AbstractNon‐benzenoid diradicaloids possessing high‐spin ground states are attractive synthetic targets given their high potential for spintronics and quantum computing. Nevertheless, the synthesis of such compounds remains highly challenging due to their inherent instability. In this work, we present the synthetic attempt towards creating a non‐benzenoid diradicaloid (1) with a triplet ground state by fusing two cyclohepta[def]fluorene units onto a benzene ring. Our synthetic approach involves both oxidation and reduction pathways. In the oxidation path, we obtained the partially dehydrogenated products 1+H and 1+2H containing an indeno[1,2‐b]fluorene core from the tetrahydro precursor (2). However, further dehydrogenation to afford the target molecule (1) did not proceed. On the other hand, with the reduction pathway, a novel tetraketone precursor (9) with two pairs of pentagons and heptagons was successfully synthesized. The subsequent nucleophilic attack however was proved to be difficult probably due to the unselective nucleophilic addition on the zigzag nanographene ketones. Furthermore, UV‐vis absorption, cyclic voltammetry, and theoretical calculations were conducted to explore the optical, electrochemical properties, and aromaticity of all the obtained molecules (1+H, 1+2H and 9). Although the desired target 1 is not achieved, our work provides insight into designing novel high‐spin non‐benzenoid NGs based on nonalternant cyclohepta[def]fluorene system.
High throughput clogging free microfluidic particle filter by femtosecond laser micromachining
Authors: Storti Filippo , Bonfadini Silvio , Mangini Maria , De Luca Anna Chiara , Criante Luigino 
Published: April 2024

AbstractIn recent decades, driven by the needs of industry and medicine, researchers have been investigating how to remove carefully from the main flow microscopic particles or clusters of them. Among all the approaches proposed, crossflow filtration is one of the most attractive as it provides a non‐destructive, label‐free and in‐flow sorting method. In general, the separation performance shows capture and separation efficiencies ranging from 70% up to 100%. However, the maximum flow rate achievable (µL/min) is still orders of magnitude away from those suitable for clinical or industrial applications mainly due to the low stiffness of the materials typically used. In this work, we propose an innovative hydrodynamic‐crossflow hybrid filter geometry, buried in a fused silica substrate by means of the femtosecond laser irradiation followed by chemical etching technique. The material high stiffness combined with the accuracy of our manufacturing technique allows the 3D fabrication of non‐deformable channels with higher aspect ratio posts, while keeping the overall device dimensions compact. The filter performance has been validated through experiments with both Newtonian (water‐based solution of microbeads) and non‐Newtonian fluids (blood), achieving separation efficiencies of up to 94% and large particles recovery rates of 100%, even at very high flow rates (mL/h).
Residual protein analysis by SDS–PAGE in clinically manufactured BM‐MSC products
Authors: Kilic Pelin , Karabudak Sema , Cosar Begum , Savran Busra Nigar , Yalcin Merve 
Published: April 2024

AbstractResidual substances that are considered hazardous to the recipient must be removed from final cellular therapeutic products manufactured for clinical purposes. In doing so, quality rules determined by competent authorities (CAs) for the clinical use of tissue‐ and cell‐based products can be met. In our study, we carried out residual substance analyses, and purity determination studies of trypsin and trypsin inhibitor in clinically manufactured bone marrow‐derived mesenchymal stromal/stem cell products, using the sodium dodecyl sulfate–polyacrylamide gel electrophoresis (SDS–PAGE) method. Despite being a semiquantitative method, SDS–PAGE has several benefits over other methods for protein analysis, such as simplicity, convenience of use, and affordability. Due to its convenience and adaptability, SDS–PAGE is still a commonly used method in many laboratories, despite its limits in dynamic range and quantitative precision. Our goal in this work was to show that SDS–PAGE may be used effectively for protein measurement, especially where practicality and affordability are the major factors. The results of our study suggest a validated method to guide tissue and cell manufacturing sites for making use of an agreeable, accessible, and cost‐effective method for residual substance analyses in clinically manufactured cellular therapies.
Evaluation of strength and stiffness degradation of RC shear walls: An integrated image processing and deep learning approach
Authors: Ji Xiaodong , Yu Yue , Gao Xiang , Zhuang Yuncheng , Zhang Shaohui 
Published: April 2024

AbstractIn the aftermath of an earthquake, damage detection and performance evaluation of structural components are imperative for assessing the residual seismic capacity of a building. In this study, an integrated image processing and deep learning approach was developed to evaluate the degradation in strength and stiffness (i.e., strength reduction and stiffness reduction) of reinforced concrete (RC) shear walls. The approach comprised two main tasks: detecting and localizing visible seismic damage from photographs and evaluating strength and stiffness degradation based on this information. The semantic segmentation network, Damage‐Net, was used for damage detection and localization. A novel crack morphological processing layer and a patch feature extraction layer were developed for damage feature extraction and compression. A lightweight deep convolutional neural network named DegradeEval‐Net_v2, featuring the upgraded dilated and separable convolution block and multi‐layer perception, was developed to link the damage feature with strength and stiffness degradation. A database comprising test data and photographs of 14 RC shear wall specimens with a flexural‐dominated behavior mode and high to intermediate ductility was constructed to train and test the DegradeEval‐Net_v2 network. The results indicate that DegradeEval‐Net_v2 substantially improved the performance assessment accuracy of damaged RC shear walls, with a 35% smaller root mean square error (RMSE) for stiffness degradation evaluation and 75% smaller RMSE for strength degradation evaluation, compared with the provisions specified in JBDPA and FEMA guidelines. Moreover, evaluation results on test sets demonstrate that introducing the damage feature extraction and compression layers effectively preserved local crack information and improved the accuracy with which stiffness reduction was evaluated. In addition, DegradeEval‐Net_v2 outperformed ResNet18 and MobileNet V3 in terms of balanced efficiency and accuracy. Interpretability analysis demonstrates that the model learned the distinct contribution patterns of various visible damage indexes to stiffness and strength degradation across different loading levels.