bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of stromal proteins overexpressed in nodular sclerosis Hodgkin lymphoma
Authors: Kischel Philippe , Waltregny David , Greffe Yannick , Mazzucchelli Gabriel , De Pauw Edwin , de Leval Laurence , Castronovo Vincent 
Published: October 2011

Abstract
Hodgkin lymphoma (HL) represents a category of lymphoid neoplasms with unique features, notably the usual scarcity of tumour cells in involved tissues. The most common subtype of classical HL, nodular sclerosis HL, characteristically comprises abundant fibrous tissue stroma. Little information is available about the protein composition of the stromal environment from HL. Moreover, the identification of valid protein targets, specifically and abundantly expressed in HL, would be of utmost importance for targeted therapies and imaging, yet the biomarkers must necessarily be accessible from the bloodstream. To characterize HL stroma and to identify potentially accessible proteins, we used a chemical proteomic approach, consisting in the labelling of accessible proteins and their subsequent purification and identification by mass spectrometry. We performed an analysis of potentially accessible proteins in lymph node biopsies from HL and reactive lymphoid tissues, and in total, more than 1400 proteins were identified in 7 samples. We have identified several extracellular matrix proteins overexpressed in HL, such as versican, fibulin-1, periostin, and other proteins such as S100-A8. These proteins were validated by immunohistochemistry on a larger series of biopsy samples, and bear the potential to become targets for antibody-based anti-cancer therapies.
Quercetin 7-rhamnoside reduces porcine epidemic diarrhea virus replication via independent pathway of viral induced reactive oxygen species
Authors: Song Jae Hyoung , Shim Jae Kwon , Choi Hwa Jung 
Published: October 2011

Abstract

Background
On the base of our previous study we were observed relevant studies on the hypothesis that the antiviral activity of quercetin 7-rhamnoside (Q7R), a flavonoid, won't relate ability of its antioxidant.

Methods
We were investigated the effects of Q7R on the cytopathic effects (CPE) by CPE reduction assay. Production of DNA fragment and reactive oxygen species (ROS) induced by PEDV infection were studied using DNA fragmentation assay and flow cytometry.

Results
In the course of this study it was discovered that Q7R is an extremely potent compound against PEDV. The addition of Q7R to PEDV-infected Vero cells directly reduced the formation of a visible cytopathic effect (CPE). Also, Q7R did not induce DNA fragmentation. Furthermore, ROS increased the infection of PEDV, which was strongly decreased by N-acetyl-L-cysteins (NAC). However, the increased ROS was not decreased by Q7R. Antiviral activity of antioxidants such as NAC, pyrrolidine dithiocarbamate (PDTC), and the vitamin E derivative, trolox, were hardly noticed.

Conclusions
We concluded that the inhibition of PEDV production by Q7R is not simply due to a general action as an antioxidants and is highly specific, as several other antioxidants (NAC, PDTC, trolox) are inactive against PEDV infection.
Dietary fat and not calcium supplementation or dairy product consumption is associated with changes in anthropometrics during a randomized, placebo-controlled energy-restriction trial
Authors: Smilowitz Jennifer T , Wiest Michelle M , Teegarden Dorothy , Zemel Michael B , German J Bruce , Van Loan Marta D 
Published: October 2011

Abstract
Insufficient calcium intake has been proposed to cause unbalanced energy partitioning leading to obesity. However, weight loss interventions including dietary calcium or dairy product consumption have not reported changes in lipid metabolism measured by the plasma lipidome.

Methods

The objective of this study was to determine the relationships between dairy product or supplemental calcium intake with changes in the plasma lipidome and body composition during energy restriction. A secondary objective of this study was to explore the relationships among calculated macronutrient composition of the energy restricted diet to changes in the plasma lipidome, and body composition during energy restriction. Overweight adults (n = 61) were randomized into one of three intervention groups including a deficit of 500kcal/d: 1) placebo; 2) 900 mg/d calcium supplement; and 3) 3-4 servings of dairy products/d plus a placebo supplement. Plasma fatty acid methyl esters of cholesterol ester, diacylglycerol, free fatty acids, lysophosphatidylcholine, phosphatidylcholine, phosphatidylethanolamine and triacylglycerol were quantified by capillary gas chromatography.

Results

After adjustments for energy and protein (g/d) intake, there was no significant effect of treatment on changes in weight, waist circumference or body composition. Plasma lipidome did not differ among dietary treatment groups. Stepwise regression identified correlations between reported intake of monounsaturated fat (% of energy) and changes in % lean mass (r = -0.44, P < 0.01) and % body fat (r = 0.48, P < 0.001). Polyunsaturated fat intake was associated with the % change in waist circumference (r = 0.44, P < 0.01). Dietary saturated fat was not associated with any changes in anthropometrics or the plasma lipidome.

Conclusions

Dairy product consumption or calcium supplementation during energy restriction over the course of 12 weeks did not affect plasma lipids. Independent of calcium and dairy product consumption, short-term energy restriction altered body composition. Reported dietary fat composition of energy restricted diets was associated with the degree of change in body composition in these overweight and obese individuals.
Selective inhibition of GluN2D-containing N-methyl-D-aspartate receptors prevents tissue plasminogen activator-promoted neurotoxicity both in vitro and in vivo
Authors: Jullienne Amandine , Montagne Axel , Orset Cyrille , Lesept Flavie , Jane David E , Monaghan Daniel T , Maubert Eric , Vivien Denis , Ali Carine 
Published: October 2011

AbstractBackgroundTissue plasminogen activator (tPA) exerts multiple functions in the central nervous system, depending on the partner with which it interacts. In particular, tPA acts as a positive neuromodulator of N-methyl-D-aspartate glutamatergic receptors (NMDAR). At the molecular level, it has been proposed that the pro-neurotoxicity mediated by tPA might occur through extrasynaptic NMDAR containing the GluN2D subunit. Thus, selective antagonists targeting tPA/GluN2D-containing NMDAR signaling would be of interest to prevent noxious effects of tPA.ResultsHere, we compared three putative antagonists of GluN2D-containing NMDAR and we showed that the new compound UBP145 ((2R*,3S*)-1-(9-bromophenan-threne-3-carbonyl)piperazine-2,3-dicarboxylic acid) is far more selective for GluN2D subunits than memantine and PPDA (phenanthrene derivative (2S*, 3R*)-1-(phenanthrene-2-carbonyl)piperazine-2,3-dicarboxylic acid). Indeed, in vitro, in contrast to the two other compounds, UBP145 prevented NMDA toxicity only in neurons expressing GluN2D (ie, in cortical but not hippocampal neurons). Furthermore, in cultured cortical neurons, UBP145 fully prevented the pro-excitotoxic effect of tPA. In vivo, we showed that UBP145 potently prevented the noxious action of exogenous tPA on excitotoxic damages. Moreover, in a thrombotic stroke model in mice, administration of UBP145 prevented the deleterious effect of late thrombolysis by tPA.ConclusionsIn conclusion, tPA exerts noxious effects on neurons by acting on GluN2D-containing NMDAR and pharmacological antagonists of GluN2D-containing NMDAR could be used to prevent the ability of tPA to promote neurotoxicity.
Norwegian trauma team leaders - training and experience: A national point prevalence study
Authors: Ringen Amund Hovengen , Hjortdahl Magnus , Wisborg Torben 
Published: October 2011

Abstract

Background
The treatment of trauma victims is a complex multi-professional task in a stressful environment. We previously found that trauma team members perceive leadership as the most important human factor. The aim of the present study was to assess the experience and education of Norwegian trauma team leaders, and allow them to describe their perceived educational needs.

Methods
We conducted an anonymous descriptive study using a point prevalence methodology based on written questionnaires. All 45 hospitals in Norway receiving severely injured trauma victims were contacted on a randomly selected weeknight during November 2009. Team leaders were asked to specify what trauma related training programs they had participated in, how much experience they had, and what further training they wished, if any.

Results
Response rate was 82%. Slightly more than half of the team leaders were residents. The median working experience as a surgeon among team leaders was 7.5 years. Sixty-eight percent had participated in multi-professional training in non-technical skills, while 54% had passed the advanced trauma life support(ATLS) course. Fifty-one percent were trained in damage control surgery. A median of one course per team leader was needed to comply with the new proposed national standards. Team leaders considered training in damage control surgery the most needed educational objective.

Conclusions
Level of experience among team leaders was highly variable and their educational background insufficient according to international and proposed national standards. Proposed national standards should be urgently implemented to ensure equal access to high quality trauma care.
Pre-operative planning for mandibular reconstruction - A full digital planning workflow resulting in a patient specific reconstruction
Authors: Essig Harald , Rana Majeed , Kokemueller Horst , von See Constantin , Ruecker Martin , Tavassol Frank , Gellrich Nils-Claudius 
Published: October 2011

Abstract

Objectives
Reconstruction of large mandiblular defects following ablative oncologic surgery could be done by using vascularized bone transfer or, more often, primarily with simultaneous or delayed bone grafting, using load bearing reconstruction plates. Bending of these reconstruction plates is typically directed along the outer contour of the original mandible. Simultaneously or in a second operation vascularized or non-vascularized bone is fixed to the reconstruction plate. However, the prosthodontic-driven backward planning to ease bony reconstruction of the mandible in terms of dental rehabilitation using implant-retained overdentures might be an eligible solution. The purpose of this work was to develop, establish and clinically evaluate a novel 3D planning procedure for mandibular reconstruction.

Materials and methods
Three patients with tumors involving the mandible, which included squamous cell carcinoma in the floor of the mouth and keratocystic odontogenic tumor, were treated surgically by hemimandibulectomy.

Results
In primary alloplastic mandible reconstruction, shape and size of the reconstruction plate could be predefined and prebent prior to surgery.

Clinical relevance
This study provides modern treatment strategies for mandibular reconstruction.
A rapid, convenient, solventless green approach for the synthesis of oximes using grindstone chemistry
Authors: Saikia Lakhinath , Baruah Jejiron Maheswari , Thakur Ashim Jyoti 
Published: October 2011

Abstract

Background
Synthesis of oximes is an important reaction in organic chemistry, because these versatile oximes are used for protection, purification, and characterization of carbonyl compounds. Nitriles, amides via Beckmann rearrangement, nitro compounds, nitrones, amines, and azaheterocycles can be synthesised from oximes. They also find applications for selective α-activation. In inorganic chemistry, oximes act as a versatile ligand.
Several procedures for the preparation of oximes exist, but, most of them have not addressed the green chemistry issue. They are associated with generation of pollutants, requirement of high reaction temperature, low yields, lack of a generalized procedure, etc. Hence, there is a demand for developing an efficient, convenient, and non-polluting or less polluting alternative method for the preparation of oximes. In this context, bismuth compounds are very useful as they are cheap in general, commercially available, air stable crystalline solids, safe, and non-toxic, hence easy to handle.

Results
Carbonyl compounds (aliphatic, heterocyclic, and aromatic) were converted into the corresponding oximes in excellent yields by simply grinding the reactants at room temperature without using any solvent in the presence of Bi2O3. Most importantly, this method minimizes waste disposal problems, provides a simple yet efficient example of unconventional methodology and requires short time.

Conclusions
We have developed a novel, quick, environmentally safe, and clean synthesis of aldoximes and ketoximes under solvent-free grinding condition.
Scanner Beep Only Means the Barcode Has Been Scanned; Barcode Scanning after Drug Administration Has Little Value; National Alert Network: Dosing Confusion with Colistimethate for Injection; Mix-ups between Risperidone and Ropinirole
Authors: Cohen Michael R. , Smetzer Judy L. 
Published: October 2011

These medication errors have occurred in health care facilities at least once. They will happen again—perhaps where you work. Through education and alertness of personnel and procedural safeguards, they can be avoided. You should consider publishing accounts of errors in your newsletters and/or presenting them at your inservice training programs. Your assistance is required to continue this feature. The reports described here were received through the Institute for Safe Medication Practices (ISMP) Medication Errors Reporting Program. Any reports published by ISMP will be anonymous. Comments are also invited; the writers' names will be published if desired. ISMP may be contacted at the address shown below. Errors, close calls, or hazardous conditions may be reported directly to ISMP through the ISMP Web site ( www.ismp.org ), by calling 800-FAIL-SAFE, or via e-mail at ismpinfo@ismp.org . ISMP guarantees the confidentiality and security of the information received and respects reporters' wishes as to the level of detail included in publications.
Spectroscopic Analysis of Petroleum Products and Lubricants
Authors: Nadkarni R. A. Kishore 
Published: October 2011

Description
This unique publication examines twelve spectroscopic techniques used in oil industry laboratories.
Twenty-four chapters provide a detailed discussion of the fundamentals of the techniques and their application in the oil analysis field. This is the only book available that describes both theory and applicability.
It also includes extensive illustrations of applications of these techniques in the field.
The Relation of Nasality and Nasalance to Nasal Port Area Based on a Computational Model
Authors: Bunton Kate , Story Brad H. 
Published: October 2011

Objective The purpose of this study was to examine the relation of perceptual ratings of nasality by experienced listeners, measures of nasalance, and the size of the nasal port opening for three simulated English corner vowels, /i/, /u/, and /a/. Design Samples were generated using a computational model that allowed for exact control of nasal port size and a direct measure of nasalance. Perceptual ratings were obtained using a paired-stimulus presentation. Participants Five experienced listeners. Main Outcome Measures Measures of nasalance and perceptual nasality ratings. Results Differences in nasalance and perceptual ratings of nasality were noted among the three vowels, with values being greater for the high vowels /i/ and /u/ compared to the low vowel Id. Listeners detected nasality for the high and low vowels simulated with nasal port areas of 0.01 and 0.15 cm2, respectively. Correlations between ratings of nasality and nasalance were high for all three vowels. Conclusions Results of the present study show a high correlation between ratings of nasality and measures of nasalance for nasal port areas ranging from 0 to 0.5 cm2. The correlations were based on sustained vowel samples. The restricted speech sample limits generalization of the findings to clinical data; however, the results are a demonstration of the usefulness of modeling to understand the perceptual phenomena of nasality.
Prediction of an Epidemic Curve: A Supervised Classification Approach
Authors: Nsoesie Elaine O. , Beckman Richard , Marathe Madhav , Lewis Bryan 
Published: October 2011

Classification methods are widely used for identifying underlying groupings within datasets and predicting the class for new data objects given a trained classifier. This study introduces a project aimed at using a combination of simulations and classification techniques to predict epidemic curves and infer underlying disease parameters for an ongoing outbreak.
Six supervised classification methods (random forest, support vector machines, nearest neighbor with three decision rules, linear and flexible discriminant analysis) were used in identifying partial epidemic curves from six agent-based stochastic simulations of influenza epidemics. The accuracy of the methods was compared using a performance metric based on the McNemar test.
The findings showed that: (1) assumptions made by the methods regarding the structure of an epidemic curve influences their performance i.e. methods with fewer assumptions perform best, (2) the performance of most methods is consistent across different individual-based networks for Seattle, Los Angeles and New York and (3) combining classifiers using a weighting approach does not guarantee better prediction.
Does Glycemic Control Offer Similar Benefits Among Patients With Diabetes in Different Regions of the World?
Authors: Woodward Mark , Patel Anushka , Zoungas Sophia , Liu Lisheng , Pan Changyu , Poulter Neil , Januszewicz Andrzej , Tandon Nikhil , Joshi Prashant , Heller Simon , Neal Bruce , Chalmers John 
Published: October 2011

OBJECTIVE
Participants in ADVANCE were drawn from many countries. We examined whether the effects of intensive glycemic control on major outcomes in ADVANCE differ between participants from Asia, established market economies (EMEs), and eastern Europe.

RESEARCH DESIGN AND METHODS
ADVANCE was a clinical trial of 11,140 patients with type 2 diabetes, lasting a median of 5 years. Demographic and clinical characteristics were compared across regions using generalized linear and mixed models. Effects on outcomes of the gliclazide modified release–based intensive glucose control regimen, targeting an HbAlc of ≤6.5%, were compared across regions using Cox proportional hazards models.

RESULTS
When differences in baseline variables were allowed for, the risks of primary outcomes (major macrovascular or microvascular disease) were highest in Asia (joint hazard ratio 1.33 [95% CI 1.17–1.50]), whereas macrovascular disease was more common (1.19 [1.00–1.42]) and microvascular disease less common (0.77 [0.62–0.94]) in eastern Europe than in EMEs. Risks of death and cardiovascular death were highest in eastern Europe, and the mean difference in glycosylated hemoglobin between the intensive and standard groups was lowest in EMEs. Despite these and other differences, the effects of intensive glycemic control were not significantly different (P ≥ 0.23) between regions for any outcome, including mortality, vascular end points, and severe hypoglycemic episodes.

CONCLUSIONS
Irrespective of absolute risk, the effects of intensive glycemic control with the gliclazide MR-based regimen used in ADVANCE were similar across Asia, EMEs, and eastern Europe. This regimen can safely be recommended for patients with type 2 diabetes in all of these regions.
Reduced Prevalence of Diabetic Ketoacidosis at Diagnosis of Type 1 Diabetes in Young Children Participating in Longitudinal Follow-Up
Authors: Elding Larsson Helena , Vehik Kendra , Bell Ronny , Dabelea Dana , Dolan Lawrence , Pihoker Catherine , Knip Mikael , Veijola Riitta , Lindblad Bengt , Samuelsson Ulf , Holl Reinhard , Haller Michael J. ,   on behalf of the TEDDY Study Group,   SEARCH Study Group,   Swediabkids Study Group,   DPV Study Group,   Finnish Diabetes Registry Study Group
Published: October 2011

OBJECTIVE
Young children have an unacceptably high prevalence of diabetic ketoacidosis (DKA) at the clinical diagnosis of type 1 diabetes. The aim of this study was to determine whether knowledge of genetic risk and close follow-up for development of islet autoantibodies through participation in The Environmental Determinants of Diabetes in the Young (TEDDY) study results in lower prevalence of DKA at diabetes onset in children aged &lt;2 and &lt;5 years compared with population-based incidence studies and registries.

RESEARCH DESIGN AND METHODS
Symptoms and laboratory data collected on TEDDY participants diagnosed with type 1 diabetes between 2004 and 2010 were compared with data collected during the similar periods from studies and registries in all TEDDY-participating countries (U.S., SEARCH for Diabetes in Youth Study; Sweden, Swediabkids; Finland, Finnish Pediatric Diabetes Register; and Germany, Diabetes Patienten Verlaufsdokumenation [DPV] Register).

RESULTS
A total of 40 children younger than age 2 years and 79 children younger than age 5 years were diagnosed with type 1 diabetes in TEDDY as of December 2010. In children &lt;2 years of age at onset, DKA prevalence in TEDDY participants was significantly lower than in all comparative registries (German DPV Register, P &lt; 0.0001; Swediabkids, P = 0.02; SEARCH, P &lt; 0.0001; Finnish Register, P &lt; 0.0001). The prevalence of DKA in TEDDY children diagnosed at &lt;5 years of age (13.1%) was significantly lower compared with SEARCH (36.4%) (P &lt; 0.0001) and the German DPV Register (32.2%) (P &lt; 0.0001) but not compared with Swediabkids or the Finnish Register.

CONCLUSIONS
Participation in the TEDDY study is associated with reduced risk of DKA at diagnosis of type 1 diabetes in young children.
Risk of Breast Cancer After Onset of Type 2 Diabetes
Authors: Bowker Samantha L. , Richardson Kathryn , Marra Carlo A. , Johnson Jeffrey A. 
Published: October 2011

OBJECTIVE
To examine the risk of breast cancer in pre- and postmenopausal women with type 2 diabetes (T2D).

RESEARCH DESIGN AND METHODS
This was a population-based retrospective cohort study. Cox regression, stratified by pre- (&lt;55 years) and postmenopausal (≥55 years) status, was used to estimate hazard ratios (HRs) for breast cancer, during earlier (0–3 months) and later (3 months to 10 years) time windows after diabetes index date.

RESULTS
Compared with women without T2D, HRs for breast cancer were 0.95 (95% CI 0.48–1.86; P = 0.88) and 1.31 (0.92–1.86; P = 0.14) in pre- and postmenopausal women with T2D, respectively, in the early time window, and 0.92 (0.75–1.13; P = 0.45) and 1.00 (0.90–1.11; P = 0.93) in pre- and postmenopausal women with T2D, respectively, in the later time window.

CONCLUSIONS
We observed a trend toward an increased risk of breast cancer in postmenopausal women with T2D, but only in the time period immediately after diabetes index date.