bluuebunny/crossref_metadata_2025_split huggingface dataset:
Individuals lack the ability to accurately detect emotional piloerection
Authors: McPhetres Jonathon , Han Ailin , Gao Halo H. , Kemp Nicole , Khati Bhakti , Pu Cathy X. , Smith Abbie , Shui Xinyu 
Published: May 2024

AbstractPiloerection (e.g., goosebumps) is an essential thermoregulatory and social signaling mechanism in non‐human animals. Although humans also experience piloerection—often being perceived as an indicator of profound emotional experiences—its comparatively less effective role in thermoregulation and communication might influence our capacity to monitor its occurrence. We present three studies (total N = 617) demonstrating participants' general inability to detect their own piloerection events and their lack of awareness that piloerection occurs with a similar frequency on multiple anatomical locations. Self‐reported goosebumps were more frequent than observed piloerection. However, only 31.8% of self‐reports coincided with observable piloerection, a bias unrelated to piloerection intensity, anatomical location, heart‐rate variability, or interoceptive awareness. We also discovered a self‐report bias for the forearm, contradicting the observation that piloerection occurs with equal frequency on multiple anatomical locations. Finally, there was low correspondence between self‐reports of being “emotionally moved” and observed piloerection. These counterintuitive findings not only highlight a disconnect between an obvious physiological response and our capacity for self‐monitoring, but they underscore a fascinating divergence between human and non‐human species. Although piloerection is vital in non‐human organisms, the connection between piloerection and psychological experience in humans may be less significant than previously assumed, possibly due to its diminished evolutionary relevance.
Oral supplementation with Scabiosa artropurperea L. aqueous extract improves the in vivo sexual behaviour, sperm quality and androgen level in rams
Authors: Niama Wijden , Saïd Samia Ben , Aroua Mohamed , Amiri Sihem , Chograni Hnia , Ramé Christelle , Bouzid Kahena , Bartakiz Ahlem , Froment Pascal , Dupont Joelle , Mahouachi Mokhtar 
Published: May 2024

AbstractThe effects of an aqueous extract of Scabiosa atropurpurea L. (AES) on the reproduction potential of Queue Fine de l'Ouest rams were evaluated over 9 weeks. Eighteen mature (4–6 years old) rams (52.8 ± 2.6 kg) were divided into three groups. The control (C) group was fed oat hay ad libitum with 700 g of concentrate and the other two groups were fed the same diet supplemented with AES at 1 and 2 mg/kg body weight (AES1 and AES2, respectively). Ram sperm was collected with an artificial vagina (2 × 2 days/week) to evaluate sperm production and quality, antioxidant activity, the adenosine triphosphate (ATP) and calcium concentrations. Sexual behaviour and plasma testosterone concentrations were also investigated. The administration of AES improved sexual behaviour (the duration of contact and the number of lateral approaches). The addition of AES also improved individual spermatozoa motility (C: 71.7% ± 6.3%; AES1: 78.3% ± 4.9%; AES2: 83.8% ± 4.4%), the sperm concentration (C: 5.6 ± 0.36; AES1: 6.4 ± 0.81; AES2: 6.7 ± 0.52 × 109 spermatozoa/mL), the ATP ratio (C: 1 ± 0.08; AES1: 2.1 ± 0.08; AES2: 3.3 ± 0.08) and the calcium concentration (C: 5.6 ± 0.24; AES1: 7.7 ± 0.21; AES2: 8.1 ± 0.24 mmol/L). AES treatment decreased the percentage of abnormal sperm (C: 18.5% ± 1.2%; AES1: 16.2% ± 1.1%; AES2: 14.8% ± 0.94%) and DNA damage (C: 62%; AES1: 27%; AES2: 33%) and was associated with elevated seminal fluid antioxidant activity (C: 22 ± 0.27; AES1: 27.1 ± 1.08 and AES2: 27.5 ± 0.36 mmol Trolox equivalents/L) and plasma testosterone (C: 8.3 ± 0.7; AES1: 11.7 ± 0.4; AES2: 15 ± 0.7 ng/L). In conclusion, our study suggests that S. atropurpurea may be potentially useful to enhance libido and sperm production and quality in ram.
Labour market trajectories and unemployment of older workers in Europe after the Great Recession
Authors: Trentini Marco 
Published: May 2024

AbstractMany European countries want to overcome the early exit from labour market which was widespread since the 1970s through pension reform and labour policies. The extension of working life is hindered by factors that the literature overlooks. This article focuses on the discontinuity of the late‐career caused by unemployment. The aim is to investigate whether older workers are at risk of unemployment and what are the transitions after spells of unemployment. The labour market trajectories of workers over 50s in 11 European countries from 2006 to 2019 were analysed, specifically after the Great Recession and before the Covid‐19 epidemic. It is based on longitudinal survey data from the generated Survey of Health, Ageing and Retirement in Europe Job Episodes Panel. Event history analysis and sequence analysis were performed. Older employees are unlikely to face unemployment. The transition rate highlights the difficulty for older workers into re‐employment. A low education level increases the risk of unemployment and remaining unemployed. Data by country confirm the trend towards overcoming the transition from unemployment to early exit. Divergences concern the higher risk of being trapped in unemployment in Southern European countries such as Greece and Italy.
Three major challenges in the shift to electric vehicles: Industrial organization, industrial policy, and a just transition
Authors: Jeong Jun Ho , Kim Chulsik , Jo Hyung Je 
Published: May 2024

AbstractThis article aims to comprehensively review current research on the transformation within the automotive industry, with a specific focus on electrification, which has driven structural shifts. The exploration of three key dimensions forms the crux of this review: the technical aspects of the transition to electric vehicles (EVs) and the diverse perspectives on EVs as an innovative icon; the array of policy interventions linked to the transition and their distinctive features; and the intricate interplay of discourse and practices integral to the concept of a just transition. Examining these dimensions reveals a disparity between aspirational ideals and current realities in the transformative phase. While the shift to EVs revolutionizes automobile design, the mirroring hypothesis of a concomitant revolution in production and organizational paradigms lacks empirical support. The socio‐ecological transition encounters conflicts between transformative advocates, arguing for robust interventionist policies to overhaul the prevailing social‐technical automotive regime, and status quo upholders favoring an ecological modernization of the regime. Furthermore, the article underscores nuanced tensions in negotiating a just transition amid diverse stakeholder positions.
Incentives for plasma donation
Authors: Koch Elena , Leiße Antonia , Veseli Besarta , Jensen Johannes , Spekman Marloes , Merz Eva‐Maria , Shehu Edlira , Thibert Jean‐Baptiste , Beurel‐Trehan Antoine , Leblond Marion , Oesterer Martin , Kluge Philipp , Forioso Donata , Clement Michel 
Published: May 2024

AbstractBackground and ObjectivesThis work provides an overview of the incentives used for plasma donation in Europe and beyond. The overview can provide new ideas to blood establishments.Materials and MethodsWe conducted a systematic online search of incentives used and asked national experts to validate the data across all European Union countries as well as other European and non‐European countries. We categorized the data into level of incentive (using the Nuffield Council on Bioethics' rungs [2011]) and country.ResultsWe analysed more than 490 organizations across 26 countries. Our findings reveal different incentives used in these countries. Snacks and pre‐donation health checks are commonly provided. In addition, loyalty programmes, small gifts, vouchers, lotteries, travel compensations and time off from work extend the strategic incentive portfolio. Only seven countries offer financial compensation ranging from the equivalent of 10–35€ for European countries. In countries with a decentralized model, where more than one organization collects plasma, we observe that more diversified incentive strategies are generally used, including monetary and non‐monetary incentives. In countries with a centralized model, where only one organization is allowed to collect plasma, financial compensation is usually not offered. Centralized plasma collection without financial compensation relies on a wider range of non‐monetary incentives than with financial compensation.ConclusionThe country group analysis offers valuable insights into the relationship between incentive strategies and the prevailing centralized versus decentralized plasma collection model. This overview provides a broader understanding of incentives used by blood establishments and offers avenues for future practice.
Exploring attitudes toward xenotransplantation: A scoping review of healthcare workers, healthcare students, and kidney patients
Authors: Rodger Daniel , Smith Jonathan A. 
Published: May 2024

AbstractBackgroundRecent advances mean that formal clinical trials of solid organ xenotransplantation are increasingly likely to begin and patients requiring a kidney transplant could be the first participants. Healthcare workers and healthcare students constitute the current and future workforce that will influence public opinion of xenotransplantation. The attitudes of these populations are important to consider before recruitment for formal clinical trials begins.MethodsThis scoping review was reported according to the PRISMA extensions for scoping reviews checklist and the Joanna Briggs Institute methodology for scoping reviews. The Scopus, PubMed, and ScienceDirect databases were searched to identify articles that studied the attitudes of healthcare workers, healthcare students, or kidney patients toward xenotransplantation.ResultsThe search generated 816 articles, of which 27 met the eligibility criteria. The studies were conducted in 14 different countries on five different continents. Participants from the 27 studies totaled 29,836—this was constituted of 6,223 (21%) healthcare workers, 21,067 (71%) healthcare students, and 2,546 (8%) kidney patients. All three groups had an overall positive attitude toward xenotransplantation. However, in studies where participants were asked to consider xenotransplantation when the risks and results were not equal to allotransplantation—the overall attitude switched from positive to negative. The results also found that Spanish‐speaking populations expressed more favorable views toward xenotransplantation compared to English‐speaking populations.ConclusionThe results of this review suggest that while attitudes of the three groups toward xenotransplantation are—on the face of it—positive, this positivity deteriorates when the risks and outcomes are framed in more clinically realistic terms. Only formal clinical trials can determine how the risks and outcomes of xenotransplantation compare to allotransplantation.
Equidistribution of high traces of random matrices over finite fields and cancellation in character sums of high conductor
Authors: Gorodetsky Ofir , Kovaleva Valeriya 
Published: May 2024

AbstractLet be a random matrix distributed according to uniform probability measure on the finite general linear group . We show that equidistributes on as as long as and that this range is sharp. We also show that nontrivial linear combinations of equidistribute as long as and this range is sharp as well. Previously equidistribution of either a single trace or a linear combination of traces was only known for , where depends on , due to work of the first author and Rodgers. We reduce the problem to exhibiting cancellation in certain short character sums in function fields. For the equidistribution of , we end up showing that certain explicit character sums modulo exhibit cancellation when averaged over monic polynomials of degree in as long as . This goes far beyond the classical range due to Montgomery and Vaughan. To study these sums, we build on the argument of Montgomery and Vaughan but exploit additional symmetry present in the considered sums.
Warm Air Bending of AZ31B Sheets Based on an Online Local Contact Heating Method
Authors: Wang Xu , Wen Tong , Liu Feng , Zhou Yin 
Published: May 2024

Abstract
Warm forming holds significant potential in shaping challenging materials due to its comprehensive advantages compared to cold and hot forming. Effective heating is crucial for precise warm forming processes. This study explored an innovative warm air bending technique employing an online local contact heating method. Heat transfer during the preheating stage and the air bending of AZ31B sheets were investigated through experiments and finite element analysis at temperatures ranging from room temperature (24 °C) to 250 °C, considering the thermomechanical coupling effect. The results indicate a significant increase in the bending center angle, advancing from 69.8 deg to more than 119 deg as the heating temperature rises from room temperature to 250 °C. Fractures were effectively eliminated when the sheet heating temperatures exceeded 150 °C. Simultaneously, as the localized heating temperature increases, a corresponding decrease in the rebound angle is observed, reducing from 10.6 deg to 2.3 deg. The findings validate the feasibility of warm air bending using online local contact heating in industrial applications, with regard to forming quality and production efficiency.
Chatter Stability of Orthogonal Turn-Milling Process in Frequency and Discrete-Time Domains
Authors: Berenji Kaveh Rahimzadeh , Tehranizadeh Faraz , Budak Erhan 
Published: May 2024

Abstract
As the industry seeks better quality and efficiency, multitasking machine tools are becoming increasingly popular owing to their ability to create complex parts in one setup. Turn-milling, a type of multi-axis machining, combines milling and turning processes to remove material through simultaneous rotations of the cutter and workpiece with the translational feed of the tool. While turn-milling can be advantageous for large parts made of hard-to-cut materials, it also offers challenges in terms of surface form errors and process stability. Because tool eccentricity and workpiece rotation lead to more complexity in process mechanics and dynamics, traditional milling stability models cannot predict the stability of turn-milling processes. This study presents a mathematical model based on process mechanics and dynamics by incorporating the unique characteristics of the orthogonal turn-milling process to avoid self-excited chatter vibrations. A novel approach was employed to model time-varying delays considering the simultaneous rotation of the tool and workpiece. Stability analysis of the system was performed in both the discrete-time and frequency domains. The effects of eccentricity and workpiece speed on stability diagrams were demonstrated and validated through experiments. The results show that the tool eccentricity and workpiece speed alter the engagement geometry and delay in the regeneration mechanism, respectively, leading to significant stability diagram alterations. The proposed approach offers a comprehensive framework for the stability of orthogonal turn-milling and guidance for the selection of process conditions to achieve stable cuts with enhanced productivity.
DesignFusion: Integrating Generative Models for Conceptual Design Enrichment
Authors: Chen Liuqing , Jing Qianzhi , Tsang Yixin , Wang Qianyi , Sun Lingyun , Luo Jianxi 
Published: May 2024

Abstract
Conceptual design is a pivotal phase of product design and development, encompassing user requirement exploration and informed solution generation. Recent generative models with their powerful content generation capabilities have been applied to conceptual design to support designers’ ideation. However, the lack of transparency in their generation process and the shallow nature of their generated solutions constrain their performance in complex conceptual design tasks. In this study, we first introduce a conceptual design generation approach that combines generative models with classic design theory. This approach decomposes the conceptual design task based on design process and design attributes, and uses the who, what, where, when, why, how (5W1H) method, function-behavior-structure model, and Kansei Engineering to guide generative models to generate conceptual design solutions through multi-step reasoning. Then we present an interactive system using a mind-map layout to visualize multi-step reasoning, called DesignFusion. This empowers designers to track the generation process and control inputs/outputs at each reasoning step. Two user studies show that our approach significantly enhances the quality of generated design solutions and enriches designer experience in human–artificial intelligence co-creation.
Discrete Structural Design Synthesis: A Hierarchical-Inspired Deep Reinforcement Learning Approach Considering Topological and Parametric Actions
Authors: Ororbia Maximilian E. , Warn Gordon P. 
Published: May 2024

Abstract
Structural design synthesis considering discrete elements can be formulated as a sequential decision process solved using deep reinforcement learning, as shown in prior work. By modeling structural design synthesis as a Markov decision process (MDP), the states correspond to specific structural designs, the discrete actions correspond to specific design alterations, and the rewards are related to the improvement in the altered design’s performance with respect to the design objective and specified constraints. Here, the MDP action definition is extended by integrating parametric design grammars that further enable the design agent to not only alter a given structural design’s topology, but also its element parameters. In considering topological and parametric actions, both the dimensionality of the state and action space and the diversity of the action types available to the agent in each state significantly increase, making the overall MDP learning task more challenging. Hence, this paper also addresses discrete design synthesis problems with large state and action spaces by significantly extending the network architecture. Specifically, a hierarchical-inspired deep neural network architecture is developed to allow the agent to learn the type of action, topological or parametric, to apply, thus reducing the complexity of possible action choices in a given state. This extended framework is applied to the design synthesis of planar structures considering both discrete elements and cross-sectional areas, and it is observed to adeptly learn policies that synthesize high performing design solutions.
T6SS nuclease effectors in
Pseudomonas syringae
act as potent antimicrobials in interbacterial competition
Authors: Yu Xun , Yan Yubo , Zeng Jie , Liu Yongxuan , Sun Xiaowen , Wang Zhiyong , Li Lin 
Published: May 2024

ABSTRACT

Type VI secretion system (T6SS) is a potent weapon employed by various
Pseudomonas
species to compete with neighboring microorganisms for limited nutrients and ecological niches. However, the involvement of T6SS effectors in interbacterial competition within the phytopathogen
Pseudomonas syringae
remains unknown. In this study, we examined two T6SS clusters in a wild-type
P. syringae
MB03 and verified the involvement of one cluster, namely, T6SS-1, in interbacterial competition. Additionally, our results showed that two T6SS DNase effectors, specifically Tde1 and Tde4, effectively outcompeted antagonistic bacteria, with Tde4 playing a prominent role. Furthermore, we found several cognate immunity proteins, including Tde1i
a
, Tde1i
b
, and Tde4i, which are located in the downstream loci of their corresponding effector protein genes and worked synergistically to protect MB03 cells from self-intoxication. Moreover, expression of either Tde1 or C-terminus of Tde4 in
Escherichia coli
cells induced DNA degradation and changes in cell morphology. Thus, our results provide new insights into the role of the T6SS effectors of
P. syringae
in the interbacterial competition in the natural environment.

IMPORTANCE

The phytopathogen
Pseudomonas syringae
employs an active type VI secretion system (T6SS) to outcompete other microorganisms in the natural environment, particularly during the epiphytic growth in the phyllosphere. By examining two T6SS clusters in
P. syringae
MB03, T6SS-1 is found to be effective in killing
Escherichia coli
cells. We highlight the excellent antibacterial effect of two T6SS DNase effectors, namely, Tde1 and Tde4. Both of them function as nuclease effectors, leading to DNA degradation and cell filamentation in prey cells, ultimately resulting in cell death. Our findings deepen our understanding of the T6SS effector repertoires used in
P. syringae
and will facilitate the development of effective antibacterial strategies.
Degradation of TRIM32 is induced by RTA for Kaposi’s sarcoma-associated herpesvirus lytic replication
Authors: Zhang Yulin , Dong Zhongwei , Gu Feng , Xu Yifei , Li Ying , Sun Wen , Rao Wutian , Du Shujuan , Zhu Caixia , Wang Yuyan , Wei Fang , Cai Qiliang 
Published: May 2024

ABSTRACT

TRIM32 is often aberrantly expressed in many types of cancers. Kaposi’s sarcoma-associated herpesvirus (KSHV) is linked with several human malignancies, including Kaposi’s sarcoma and primary effusion lymphomas (PELs). Increasing evidence has demonstrated the crucial role of KSHV lytic replication in viral tumorigenesis. However, the role of TRIM32 in herpesvirus lytic replication remains unclear. Here, we reveal that the expression of TRIM32 is upregulated by KSHV in latency, and reactivation of KSHV lytic replication leads to the inhibition of TRIM32 in PEL cells. Strikingly, RTA, the master regulator of lytic replication, interacts with TRIM32 and dramatically promotes TRIM32 for degradation via the proteasome systems. Inhibition of TRIM32 induces cell apoptosis and in turn inhibits the proliferation and colony formation of KSHV-infected PEL cells and facilitates the reactivation of KSHV lytic replication and virion production. Thus, our data imply that the degradation of TRIM32 is vital for the lytic activation of KSHV and is a potential therapeutic target for KSHV-associated cancers.

IMPORTANCE
TRIM32 is associated with many cancers and viral infections; however, the role of TRIM32 in viral oncogenesis remains largely unknown. In this study, we found that the expression of TRIM32 is elevated by Kaposi’s sarcoma-associated herpesvirus (KSHV) in latency, and RTA (the master regulator of lytic replication) induces TRIM32 for proteasome degradation upon viral lytic reactivation. This finding provides a potential therapeutic target for KSHV-associated cancers.