bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Intramolecular Conjugate Addition of α,β‐Unsaturated Lactones Having an Alkanenitrile Side Chain: Stereocontrolled Construction of Carbocycles with Quaternary Carbon Atoms.
Authors: Yoshimura Fumihiko , Torizuka Makoto , Mori Genki , Tanino Keiji 
Published: April 2012

AbstractThe efficient methodology allows the construction of carbocycles with all‐carbon quarternary stereocenters from α,β‐unsaturated lactones having an alkanenitrile side chain.
ChemInform Abstract: Synthesis of Polysubstituted 3‐Hydroxypyridines via the Revisited Hetero‐Diels—Alder Reaction of 5‐Alkoxyoxazoles with Dienophiles.
Authors: Sabot Cyrille , Oueis Emilia , Brune Xavier , Renard Pierre‐Yves 
Published: April 2012

AbstractNeodymium triflate is an efficient catalyst which leads to a variety of substituted 3‐hydroxypyridines such as (III) and (VIII).
ChemInform Abstract: Design and Combinatorial Synthesis of a Novel Kinase‐Focused Library Using Click Chemistry‐Based Fragment Assembly.
Authors: Irie Takayuki , Fujii Ikuo , Sawa Masaaki 
Published: April 2012

AbstractThe screening of the triazole‐based kinase focused evolved fragment library (76 examples) allows for the rapid identification of the potent lead candidate (Ia) for FLT3 and GSK3β kinase.
ChemInform Abstract: A Convenient One‐Pot Synthesis of 1‐Aryl‐Substituted 2H‐Isoquinolin‐3‐ones.
Authors: Mendez Leticia J. , Canepa Alicia S. , Gonzalez M. Gloria , Bravo Rodolfo D. 
Published: April 2012

AbstractThe title compounds (III) are prepared from 2‐cyanomethylbenzoic acid and arenes via sequential Friedel—Crafts acylation and intramolecular cyclization.
ChemInform Abstract: Synthesis of Methyl 9‐Mesityl‐12‐aryl‐11‐oxo‐7,8,9,10,11,12‐hexahydrobenzo [a]acridine‐10‐carboxylates.
Authors: Kozlov N. G. 
Published: April 2012

Abstractby condensation of 2‐naphthylamine with 2‐mesityl‐4,6‐dioxocyclohexanecarboxylate and aromatic aldehydes
ChemInform Abstract: Synthesis of δ‐Carbolines via a Pd‐Catalyzed Sequential Reaction from 2‐Iodoanilines and N‐Tosyl‐enynamines.
Authors: Cao Jian , Xu Yongping , Kong Yulong , Cui Yuming , Hu Ziqiang , Wang Guanhai , Deng Yuan , Lai Guoqiao 
Published: April 2012

AbstractThe preparation of the important heterocyclic skeleton proceeds with moderate to good yields if both substrates are aryl‐substituted.
ChemInform Abstract: One‐Pot Access to Indolo[2,3‐b]quinolines by Electrophile‐Triggered Cross‐Amination/Friedel—Crafts Alkylation of Indoles with 1‐(2‐Tosylaminophenyl)ketones.
Authors: Ali Shaukat , Li Ying‐Xiu , Anwar Saeed , Yang Fang , Chen Zi‐Sheng , Liang Yong‐Min 
Published: April 2012

AbstractThe method can be applied to prepare neocryptolepine (VII) and its analogues.
ChemInform Abstract: Iridium‐Catalyzed [2 + 2 + 2] Cycloaddition of α,ω‐Diynes with Isocyanates.
Authors: Onodera Gen , Suto Mari , Takeuchi Ryo 
Published: April 2012

AbstractThe reaction allows a new and mild access to a number of fused pyridines and the enantioselective synthesis of axially chiral pyridones is possible.
ChemInform Abstract: Inhibition of Noroviruses by Piperazine Derivatives.
Authors: Dou Dengfeng , He Guijia , Mandadapu Sivakoteswara Rao , Aravapalli Sridhar , Kim Yunjeong , Chang Kyeong‐Ok , Groutas William C. 
Published: April 2012

AbstractThe studies lead to the identification of two promising compounds (I) and (II) which can be used as a launching pad for the optimization of potency, cytotoxicity and drug‐like characteristics.
ChemInform Abstract: Ultrasound‐Accelerated One‐Pot Synthesis of N‐Acetyl‐2‐aryl‐1,2‐dihydro‐4H‐3,1‐benzoxazin‐4‐ones.
Authors: Azarifar D. , Sheikh D. 
Published: April 2012

AbstractA novel approach to 2‐aryl substituted benzoxazin‐4‐ones (IV) is presented.
ChemInform Abstract: Synthesis and in vitro and in vivo Anticancer Activity of Novel Phenylmethylene Bis‐isoxazolo[4,5‐b]azepines.
Authors: Rajanarendar E. , Reddy M. Nagi , Murthy K. Rama , Surendar P. , Reddy R. N. , Reddy Y. N. 
Published: April 2012

AbstractA series of title compounds (I) (10 examples) is synthesized and screened for in vitro and in vivo anticancer activity.
ChemInform Abstract: One‐Pot Synthesis of Fused Pyridazino[4,5‐b][1,4]oxazepine‐diones via Smiles Rearrangement.
Authors: Liu Yanli , Ma Ying , Zhan Chunjing , Huang Aiping , Ma Chen 
Published: April 2012

AbstractA convenient synthesis of title compounds (III) from salicyclamides and dichloropyridazinone (II) is achieved by a one‐pot coupling/Smiles rearrangement/cyclization.
ChemInform Abstract: Stereoselective Synthesis of Sugar Fused β‐Disubstituted γ‐Butyro‐lactones: C‐Spiro‐glycosides from 1,2‐Cyclopropanecarboxylated Sugars.
Authors: Sridhar Perali Ramu , Seshadri Kalapati , Reddy Gadi Madhusudhan 
Published: April 2012

AbstractSeven C‐spiro‐glycosides are readily prepared by treatment of bromohydrin (II) and its analogues with potassium carbonate as a mild base.
ChemInform Abstract: [R4N] [AOT]: A Surfactant Ionic Liquid as a Mild Glycosylation Promoter.
Authors: Galan M. Carmen , Tran Anh Tuan , Boisson Julien , Benito David , Butts Craig , Eastoe Julian , Brown Paul 
Published: April 2012

AbstractApplication of a new class of surfactant ionic liquids mildly activate thioglycosides when used in combination with NIS to promote the glycosylation of donors (I), (IV), and (VI).
ChemInform Abstract: Synthesis of Azide‐Armed α‐1‐C‐Alkyl‐imino‐D‐xylitol Derivatives as Key Building Blocks for the Preparation of Iminosugar Click Conjugates.
Authors: Decroocq Camille , Mamani Laparra Laura , Rodriguez‐Lucena David , Compain Philippe 
Published: April 2012

AbstractTitle derivative (X) and its Boc‐protected precursor are synthesized by means of olefin cross‐metathesis in eight to nine steps and in an overall yield of 19 to 26% from xylopyranose (I).
ChemInform Abstract: Toward Green and Sustainable Chemical Glycosylation: Enhanced Lewis Acidity of Recyclable Solid Super Acid Catalyst, SO4/ZrO2 by CaCl2 Doping.
Authors: Hinou Hiroshi , Saito Naohiro , Maeda Takahiro , Matsuda Masao , Kamiya Yuichi , Nishimura Shin‐Ichiro 
Published: April 2012

AbstractThe enhanced glycosylation efficacy concerning the calcium chloride‐doped sulfated zirconia significantly depends on the ion radius of the calcium cation and how calcium chloride coordinates to the oxygen atom of sulfated zirconia to convert a Broensted acid site into a much more functional Lewis acid site.
ChemInform Abstract: Rh(II) Carbene‐Mediated Synthesis of Methyl α‐ and β‐Ketopyranosides: Preparation of Carbene Precursors, Quaternarization of the Anomeric Position, and Ring Opening of γ‐Lactones.
Authors: Boultadakis‐Arapinis Melissa , Lescot Camille , Micouin Laurent , Lecourt Thomas 
Published: April 2012

AbstractCarbene‐mediated quaternarization of the anomeric position of methyl α‐manno‐and β‐glucopyranosides yields the corresponding ketopyranosides in the presence of Rh(II) salts.
ChemInform Abstract: Cytotoxic Esterified Diterpenoid Alkaloid Derivatives with Increased Selectivity Against a Drug‐Resistant Cancer Cell Line.
Authors: Wada Koji , Ohkoshi Emika , Morris‐Natschke Susan L. , Bastow Kenneth F. , Lee Kuo‐Hsiung 
Published: April 2012

Abstract20 new diterpenoid alkaloid derivatives of type (I) are synthesized by esterification of delpheline and evaluated for their cytotoxic activity against several cancer cell lines.
ChemInform Abstract: Design and Synthesis of Carbocyclic Versions of Furanoid Nucleoside Phosphonic Acid Analogues as Potential anti‐HIV Agents.
Authors: Kim Eunae , Shen Guang Huan , Hong Joon Hee 
Published: April 2012

AbstractNucleoside phosphonate analogue (VIII) and its SATE prodrug (X) display significant antiviral activity against HIV in vitro.
ChemInform Abstract: Synthesis and Biological Activity of Bimorpholine (VI) and Its Carbanucleoside (VII).
Authors: Ausmees Kerti , Selyutina Anastasia , Kuett Kristel , Lippur Kristin , Pehk Tonis , Lopp Margus , Zusinaite Eva , Merits Andres , Kanger Tonis 
Published: April 2012

AbstractNovel carbanucleoside (VII) displays high cytotoxicity, whilst the parent bimorpholine (VI) is only moderately cytotoxic.
ChemInform Abstract: Synthesis and Biological Evaluation of 4α/4β‐Imidazolyl Podophyllotoxin Analogues as Antitumor Agents.
Authors: Shang Hai , Chen Hong , Zhao Dongmei , Tang Xiaowei , Liu Yongfeng , Pan Li , Cheng Maosheng 
Published: April 2012

AbstractA series of novel imidazolyl‐podophyllotoxin analogues is designed, synthesized and evaluated for anticancer activity against a panel of three human cancer cell lines.
ChemInform Abstract: Absolute Configuration of Pterocidin, a Potent Inhibitor of Tumor Cell Invasion from a Marine‐Derived Streptomyces.
Authors: Igarashi Yasuhiro , Asano Daisuke , Furihata Kazuo , Oku Naoya , Miyanaga Satoshi , Sakurai Hiroaki , Saiki Ikuo 
Published: April 2012

AbstractThe absolute configuration of pterocidin (I) and its degradation product (II) is established on the basis of NMR‐analysis.
Isolation and characterization of melanopsin photoreceptors of atlantic salmon (Salmo salar)
Authors: Sandbakken Mari , Ebbesson Lars , Stefansson Sigurd , Helvik Jon Vidar 
Published: April 2012

AbstractMelanopsins constitute a recently described group of vertebrate opsin photoreceptors that are involved in nonvisual photoreception. Here we describe the identification of six melanopsin genes of Atlantic salmon (Salmo salar), a valuable teleost model for studying nonvisual photoreception and the basis of photoperiodism. The results show that genes belonging to two different groups, the mammalian‐like (Opn4m) and the Xenopus‐like (Opn4x) melanopsins have been duplicated in teleosts. In addition, two pairs of salmon duplicates were identified, presumably originating from the salmon lineage whole genome duplication event. The expression pattern of melanopsins was studied by in situ hybridization. The results show that Opn4m and Opn4x melanopsins are differentially expressed in the brain and retina, indicating a functional divergence. In the retina, Opn4m and Opn4x melanopsin are differentially expressed in ganglion, amacrine, and horizontal cells. In the brain, Opn4m is expressed in the dorsal thalamus and in the nucleus lateralis tuberis of the hypothalamus, which is closely connected to and involved in the regulation of pituitary function. Opn4x melanopsins are expressed in the dopaminergic, hypophysiotrophic cell population of the suporaoptic/chiasmatic nucleus and in the serotonergic cell population of the left habenula. The results suggest that melanopsin photoreceptors can be involved in signaling of photoperiodic information through multiple pathways, involving both the retina and possibly as deep‐brain photoreceptors directly transmitting photoperiodic information to the hypothalamus–pituitary axis. J. Comp. Neurol. 520:3727–3744, 2012. © 2012 Wiley Periodicals, Inc.
Selective distribution of GABAA receptor subtypes in mouse spinal dorsal horn neurons and primary afferents
Authors: Paul Jolly , Zeilhofer Hanns Ulrich , Fritschy Jean‐Marc 
Published: April 2012

AbstractIn the spinal cord dorsal horn, presynaptic GABAA receptors (GABAARs) in the terminals of nociceptors as well as postsynaptic receptors in spinal neurons regulate the transmission of nociceptive and somatosensory signals from the periphery. GABAARs are heterogeneous and distinguished functionally and pharmacologically by the type of α subunit variant they contain. This heterogeneity raises the possibility that GABAAR subtypes differentially regulate specific pain modalities. Here, we characterized the subcellular distribution of GABAAR subtypes in nociceptive circuits by using immunohistochemistry with subunit‐specific antibodies combined with markers of primary afferents and dorsal horn neurons. Confocal laser scanning microscopy analysis revealed a distinct, partially overlapping laminar distribution of α1–3 and α5 subunit immunoreactivity in laminae I–V. Likewise, a layer‐specific pattern was evident for their distribution among glutamatergic, γ‐aminobutyric acid (GABA)ergic, and glycinergic neurons (detected in transgenic mice expressing vesicular glutamate transporter 2–enhanced green fluorescent protein [vGluT2–eGFP], glutamic acid decarboxylase [GAD]67–eGFP, and glycine transporter 2 (GlyT2)–eGFP, respectively). Finally, all four subunits could be detected within primary afferent terminals. C‐fibers predominantly contained either α2 or α3 subunit immunoreactivity; terminals from myelinated (Aβ/Aδ) fibers were colabeled in roughly equal proportion with each subunit. The presence of axoaxonic GABAergic synapses was determined by costaining with gephyrin and vesicular inhibitory amino acid transporter to label GABAergic postsynaptic densities and terminals, respectively. Colocalization of the α2 or α3 subunit with these markers was observed in a subset of C‐fiber synapses. Furthermore, gephyrin mRNA and protein expression was detected in dorsal root ganglia. Collectively, these results show that differential GABAAR distribution in primary afferent terminals and dorsal horn neurons allows for multiple, circuit‐specific modes of regulation of nociceptive circuits. J. Comp. Neurol. 520:3895–3911, 2012. © 2012 Wiley Periodicals, Inc.
Galanin gene expression and effects of its knock‐down on the development of the nervous system in larval zebrafish
Authors: Podlasz P. , Sallinen V. , Chen Y.‐C. , Kudo H. , Fedorowska N. , Panula P. 
Published: April 2012

AbstractDespite the known importance of galanin in the nervous system of vertebrates, the galanin gene structure and expression and the consequences of galanin deficiency in developing zebrafish are unknown. We cloned the galanin gene and analyzed its expression by using in situ hybridization, PCR, and immunocytochemistry throughout the early development of zebrafish until the end of the first week of life. The single zebrafish galanin gene encoded for a single amidated galanin peptide and a galanin message‐associated peptide. Two forms resulting from alternative processing were identified. Galanin mRNA was maternally expressed and found in developing fish throughout early development. In situ hybridization showed the first positive neurons in three groups in the brain at 28 hours postfertilization. At 2 days postfertilization, three prosencephalic neuron groups were seen in the preoptic area and in rostral and caudal periventricular hypothalamus. In addition, two other groups of weakly stained neurons were visible, one in the midbrain and another in the hindbrain. Translation inhibition of galanin mRNA with morpholino oligonucleotides caused complete disappearance of galanin immunoreactivity in the brain until 7 dpf and did not induce known cascades of nonspecific pathways or morphological abnormalities. A minor disturbance of sensory ganglia was found. Galanin knockdown did not alter the expression of tyrosine hydroxylases 1 and 2, choline acetyltransferase, histidine decarboxylase, or orexin mRNA. The results suggest that galanin does not regulate the development of these key markers of specific neurons, although galanin‐expressing fibers were in a close spatial proximity to several neurons of these neuronal populations. J. Comp. Neurol. 520:3846–3862, 2012. © 2012 Wiley Periodicals, Inc.
Scalable RDF data compression with MapReduce
Authors: Urbani Jacopo , Maassen Jason , Drost Niels , Seinstra Frank , Bal Henri 
Published: April 2012

SUMMARYThe Semantic Web contains many billions of statements, which are released using the resource description framework (RDF) data model. To better handle these large amounts of data, high performance RDF applications must apply a compression technique. Unfortunately, because of the large input size, even this compression is challenging. In this paper, we propose a set of distributed MapReduce algorithms to efficiently compress and decompress a large amount of RDF data. Our approach uses a dictionary encoding technique that maintains the structure of the data. We highlight the problems of distributed data compression and describe the solutions that we propose. We have implemented a prototype using the Hadoop framework, and evaluate its performance. We show that our approach is able to efficiently compress a large amount of data and scales linearly on both input size and number of nodes. Copyright © 2012 John Wiley & Sons, Ltd.
Combination of DQ and ZQ Coherences for Sensitive Through‐Bond NMR Correlation Experiments in Biosolids under Ultra‐Fast MAS
Authors: Webber Amy L. , Pell Andrew J. , Barbet‐Massin Emeline , Knight Michael J. , Bertini Ivano , Felli Isabella C. , Pierattelli Roberta , Emsley Lyndon , Lesage Anne , Pintacuda Guido 
Published: April 2012

AbstractA double‐zero quantum (DZQ)‐refocused INADEQUATE experiment is introduced for J‐based NMR correlations under ultra‐fast (60 kHz) magic angle spinning (MAS). The experiment records two spectra in the same dataset, a double quantum–single quantum (DQ‐SQ) and zero quantum–single quantum (ZQ‐SQ) spectrum, whereby the corresponding signals appear at different chemical shifts in ω1. Furthermore, the spin‐state selective excitation (S3E) J‐decoupling block is incorporated in place of the second refocusing echo of the INADEQUATE scheme, providing an additional gain in sensitivity and resolution. The two sub‐spectra acquired in this way can be treated separately by a shearing transformation, producing two diagonal‐free single quantum (SQ‐SQ)‐type spectra, which are subsequently recombined to give an additional sensitivity enhancement, thus offering an improvement greater than a factor of two as compared to the original refocused INADEQUATE experiment. The combined DZQ scheme retains transverse magnetization on the initially polarized (I) spin, which typically exhibits a longer transverse dephasing time (T2′) than its through‐bond neighbour (S). By doing so, less magnetization is lost during the refocusing periods in the sequence to give even further gains in sensitivity for the J correlations. The experiment is demonstrated for the correlation between the carbonyl (CO) and alpha (CA) carbons in a microcrystalline sample of fully protonated, [15N,13C]‐labelled CuII, ZnII superoxide dismutase, and its efficiency is discussed with respect to other J‐based schemes.
High‐Temperature Proton‐Exchange‐Membrane Fuel Cells Using an Ether‐Containing Polybenzimidazole Membrane as Electrolyte
Authors: Li Jin , Li Xiaojin , Zhao Yun , Lu Wangting , Shao Zhigang , Yi Baolian 
Published: April 2012

AbstractHerein, poly[2,2′‐(p‐oxydiphenylene)‐5,5′‐benzimidazole] (PBI) is synthesized from 3,3′‐diaminobenzidine and 4,4′‐oxybisbenzoic acid, and the membrane is prepared by solvent casting. The main characteristics of PBI are studied. In the preparation of the PBI/H3PO4 composite membrane, the absorbing temperature of H3PO4 is 120 °C, which leads to a membrane with a high content of H3PO4. Membrane electrode assemblies (MEAs) are fabricated from PBI/H3PO4 membranes with the catalyst layer made of Pt/C, PBI, and polyvinylidene fluoride (230:12:7 w/w). The fabricated MEA is tested at 150 °C with dry hydrogen and oxygen gas at 0.2 MPa for both anode and cathode feeds. No degradation of voltage is seen during stability testing of the PBI/H3PO4 membrane at a constant current for 100 h. The maximum power density is 1.17 W cm−2, and the maximum current density is 6.0 A cm−2 with a Pt loading of 0.5 mg cm−2. The high performance of these membrane materials demonstrates that PBI can be regarded as an alternative membrane material for high‐temperature proton‐exchange‐membrane fuel cells.
Fast texture synthesis with cellular neural network‐based patch stitching
Authors: Ślot Krzysztof , Kornatowski Łukasz , Dȩbiec Piotr 
Published: April 2012

ABSTRACTThe presented paper introduces a novel approach to patch‐based texture synthesis. The proposed method utilizes Cellular Neural Networks (CNNs) for patch stitching, the most important operation of the synthesis procedure, expected to transform a patchwork made up of pieces of some small texture sample into a seamless, large texture. To fill in between‐patch gaps, spontaneous pattern formation capabilities of CNNs are used. By using autoregressive filtering framework, we show that CNNs can be designed to generate complex stochastic fields that approximate stochastic and near‐stochastic textures. The proposed texture‐synthesis procedure is the following. After creating a patchwork from randomly drawn pieces of a small target texture, we fix boundary CNN conditions to edge pixels of all patches subject to stitching and execute an appropriately derived texture‐approximating template. Finally, brightness of the resulting patterns is locally adjusted by executing a diffusion CNN template. As both processing steps involve pure CNN dynamics, the proposed patch‐stitching method can be extremely fast if implemented in existing hardware (at the order of milliseconds for synthesizing several megapixel images). Copyright © 2012 John Wiley & Sons, Ltd.
A Cre knock‐in mouse line on the Sickle tail locus induces recombination in the notochord and intervertebral disks
Authors: Abe Koichiro , Araki Kimi , Tanigawa Maya , Semba Kei , Ando Takashi , Sato Masahiro , Sakai Daisuke , Hiyama Akihiko , Mochida Joji , Yamamura Ken‐Ichi 
Published: April 2012

AbstractSickle tail (Skt) was originally identified by gene trap mutagenesis in mice, and the trapped gene is highly expressed in the notochord, intervertebral discs (IVD), and mesonephros. Here, we report the generation of Sktcre mice expressing Cre recombinase in the IVD due to target insertion of the cre gene into the Skt locus by recombinase‐mediated cassette exchange. Crossing a conditional lacZ Reporter (R26R), Cre expression from the Sktcre allele specifically activates β‐galactosidase expression in the whole notochord from E9.5 onwards. In E15.5 Sktcre;R26R embryos, reporter activity was detected in the nucleus pulposus and in a portion of the annulus fibrosus, resulting in expansion of Cre‐expressing cells in the adult IVD. Reporter activity was also seen in the Sktcre;R26R mesonephros at E15.5. These results suggest that Sktcre mice are useful for exploring the fate specification of notochordal cells and creating models for IVD‐related skeletal diseases. genesis 50:758–765, 2012. © 2012 Wiley Periodicals, Inc.
Assessing the seasonal dynamics of inundation, turbidity, and aquatic vegetation in the Australian wet–dry tropics using optical remote sensing
Authors: Ward D. P. , Hamilton S. K. , Jardine T. D. , Pettit N. E. , Tews E. K. , Olley J. M. , Bunn S. E. 
Published: April 2012

ABSTRACTFloodplain wetlands in the wet–dry tropics are under increasing pressure from water resource development, and there is a need for methods to assess the biophysical dynamics of these extensive and often remote ecosystems. This study assessed the capacity of optical remote sensing methods to monitor the seasonal dynamics of inundation, turbidity, and aquatic vegetation cover for a northern Australian savanna catchment. MODIS data were used to map seasonal flood inundation patterns, and Landsat 5 TM data were used to map dry‐season waterbody dynamics. A network of water‐depth loggers and temperature sensors provided ground observations of surface inundation dynamics, and was used to validate the inundation mapping. Post‐flood waterbody surface area declined by 89% over the dry season, with 70% of the decline occurring for Palustrine (floodplain) waterbodies. All aquatic systems became increasingly disconnected as the dry season progressed. Statistical relationships were developed between seasonal measurements of turbidity, aquatic vegetation cover, and Landsat spectral data. Catchment wide predictions showed that turbidity increased and macrophyte cover decreased for the Palustrine and Lacustrine (lake) systems, while the Riverine systems became less turbid over the dry season. These results show that, for open savanna landscapes where cloud cover does not limit waterbody detection, optical remote sensing methods can be effectively applied to assess seasonal patterns of inundation and accompanying biophysical dynamics. This provides an effective tool to evaluate the impact of river flow regime changes from water resource use or climate change in these regions. Copyright © 2012 John Wiley & Sons, Ltd.