bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cross-condition bearing fault detection based on online drift detection and domain adaptation
Authors: Cao Shijing 
Published: June 2024

Abstract
Aiming at the problem that the data distribution of bearings across operating conditions generates offset resulting in insufficient diagnostic accuracy of the original model for new data, a cross-condition bearing fault detection method based on online drift detection and domain adaptation is proposed. First, the original one-dimensional vibration signals collected are transformed by a two-dimensional wavelet transform to convert the time-frequency image dataset. Second, the drift detection of the data across operating conditions is carried out using Random Forest (RF), and the 3σ criterion as well as the drift detection judgment criteria are set. Next, the source domain model based on Googlenet is used to extract features from the target domain data, and the Whale Optimization Algorithm to Improve Local Preserving Projection Algorithm (WOA-LPP) algorithm is combined to construct a brand-new projection space to align the features of the source and target domains. Then, the source and target domain features are reconstructed by combining the LPP optimal projection matrix to construct a fully connected network trained by the source domain features. Finally, probabilistic label-based decision fusion is proposed to integrate multiple classifiers to reduce the effects of model training randomness and strong noise interference. Validated by the publicly available Western Reserve University bearing data, the method proposed in this paper has good detection accuracy as well as robustness across operating conditions, which can effectively improve the defects of shifting data distribution and degradation of model accuracy under variable speed.
Linking local climate scenarios to global warming levels: applicability, prospects and uncertainties
Authors: Becsi Benedikt , Formayer Herbert 
Published: June 2024

Abstract
Global warming levels (GWLs) are increasingly becoming a central concept in climate change studies. In recent years, their integrative quality for climate change impact analysis has been demonstrated, and methodological advancements have helped to compensate for some inherent shortfalls of the concept. However, their applicability at the regional and local level is debatable, and no study to date has examined the possibility of linking local climate scenarios to GWLs. For the case of Austria, we evaluate the relation between global and regional warming patterns, and whether version changes of global climate models could be incorporated into local climate scenarios by means of the GWLs concept, without updating the actual data. We apply the time sampling approach, where GWLs are determined as periods when global mean temperature anomalies cross a certain threshold. GWL periods are sampled both from the global models in the background of the local climate scenarios (CMIP5), and from an equivalent ensemble of newer-generation climate models (CMIP6). Uncertainties resulting from sampling GWLs from different global climate model ensembles are examined, and prospects for local climate change impact assessments are discussed. Accounting for updated global climate model versions might be useful when the changes at certain GWLs are related to fixed reference periods, but temperature increments between GWLs remain relatively constant across model versions, even on the regional level. The study bridges a significant gap to link local climate projections to GWLs. Climate change impacts assessments that build on those datasets can benefit from the integrative character of GWLs, making studies comparable across multiple disciplines and model versions, and thus fostering a way to communicate local climate change impacts more comprehensible.
Different pathways toward net-zero emissions imply diverging health impacts: a health impact assessment study for France
Authors: Moutet Léo , Bigo Aurélien , Quirion Philippe , Temime Laura , Jean Kévin 
Published: June 2024

Abstract
In the transport sector, efforts to achieve carbon neutrality may generate public health co-benefits by promoting physical activity. This study aims to quantify the health impacts related to active transport based on four different scenarios leading France toward carbon neutrality in 2050. The French Agency for Ecological Transition developed four consistent and contrasting scenarios (S1 to S4) achieving carbon neutrality by 2050 as well as a business-as-usual (BAU) scenario that extends our current lifestyles until 2050, without reaching net-zero. For each of these Transitions2050 scenarios, we distributed the mobility demand for walking, cycling and e-cycling across age groups. Relying on the health impact assessment framework, we quantified the impacts of the corresponding physical activity on all-cause mortality. The impact of each of the carbon neutrality scenarios was determined by comparison with estimates from the BAU scenario. In S1 and S2 scenarios, volumes of active transport are projected to increase to fulfill the World Health Organizations (WHO) recommendations by 2050, while they increase slightly in S3 and decrease in S4. S2 scenario reaches the highest levels of health co-benefits, with 494 000 deaths prevented between 2021 and 2050. This would translate into a life expectancy gain of 3.0 months for the general population in 2050, mainly driven by e-bikes. S1 would provide smaller but important health benefits, while these benefits would be modest for S3. On the contrary, S4 implies 52 000 additional deaths as compared to the BAU scenario and a loss of 0.2 month in life expectancy. Different ways to decarbonize mobility in a net-zero perspective may achieve very contrasting public health co-benefits. This study illustrates how the public health dimension may provide a relevant insight in choices of collective transformation toward net-zero societies.
AMLdb: a comprehensive multi-omics platform to identify biomarkers and drug targets for acute myeloid leukemia
Authors: Vinod Kumar Keerthana , Kumar Ambuj , Kundal Kavita , Sengupta Avik , R Kunjulakshmi , Singh Subashani , Korra Bhanu Teja , Sharma Simran , Suresh Vandana , Nishana Mayilaadumveettil , Kumar Rahul 
Published: June 2024

Abstract
Acute myeloid leukemia (AML) is one of the leading leukemic malignancies in adults. The heterogeneity of the disease makes the diagnosis and treatment extremely difficult. With the advent of next-generation sequencing (NGS) technologies, exploration at the molecular level for the identification of biomarkers and drug targets has been the focus for the researchers to come up with novel therapies for better prognosis and survival outcomes of AML patients. However, the huge amount of data from NGS platforms requires a comprehensive AML platform to streamline literature mining efforts and save time. To facilitate this, we developed AMLdb, an interactive multi-omics platform that allows users to query, visualize, retrieve, and analyse AML related multi-omics data. AMLdb contains 86 datasets for gene expression profiles, 15 datasets for methylation profiles, CRISPR-Cas9 knockout screens of 26 AML cell lines, sensitivity of 26 AML cell lines to 288 drugs, mutations in 41 unique genes in 23 AML cell lines, and information on 41 experimentally validated biomarkers. In this study, we have reported five genes, i.e. CBFB, ENO1, IMPDH2, SEPHS2, and MYH9 identified via our analysis using AMLdb. ENO1 is uniquely identified gene which requires further investigation as a novel potential target while other reported genes have been previously confirmed as targets through experimental studies. Top of form we believe that these findings utilizing AMLdb can make it an invaluable resource to accelerate the development of effective therapies for AML and assisting the research community in advancing their understanding of AML pathogenesis. AMLdb is freely available at https://project.iith.ac.in/cgntlab/amldb.
Far-Right Extremism, Elections and Hate Crime: A Temporal Evaluation of Bias-Motivated Violence in Slovakia
Authors: Whittington Whitney , Piatkowska Sylwia J 
Published: June 2024

Abstract
The present study provides an initial attempt to assess the impact of extremist right electoral support on racially motivated and extremist violent crime rates across Slovak regions. We transcend previous research by examining associations between national and regional elections, immigration rates, vote-shares, and violent hate crime rates utilizing temporal statistics on racially motivated and extremist violent crimes, which are linked with data on support for nationalist parties and on indicators of socio-economic development. Results illustrate that extreme right parties matter, such that the higher their electoral vote-shares, the higher the violent hate crime incidence and victimization rates. We, also, find that high immigration rates strengthen the effect of electoral vote-shares on bias crime in Slovakia.
Observing the suppression of individual aversive memories from conscious awareness
Authors: Lin Xuanyi , Chen Danni , Liu Jing , Yao Ziqing , Xie Hui , Anderson Michael C , Hu Xiaoqing 
Published: June 2024

Abstract
When reminded of an unpleasant experience, people often try to exclude the unwanted memory from awareness, a process known as retrieval suppression. Here we used multivariate decoding (MVPA) and representational similarity analyses on EEG data to track how suppression unfolds in time and to reveal its impact on item-specific cortical patterns. We presented reminders to aversive scenes and asked people to either suppress or to retrieve the scene. During suppression, mid-frontal theta power within the first 500 ms distinguished suppression from passive viewing of the reminder, indicating that suppression rapidly recruited control. During retrieval, we could discern EEG cortical patterns relating to individual memories—initially, based on theta-driven visual perception of the reminders (0 to 500 ms) and later, based on alpha-driven reinstatement of the aversive scene (500 to 3000 ms). Critically, suppressing retrieval weakened (during 360 to 600 ms) and eventually abolished item-specific cortical patterns, a robust effect that persisted until the reminder disappeared (780 to 3000 ms). Representational similarity analyses provided converging evidence that retrieval suppression weakened the representation of target scenes during the 500 to 3000 ms reinstatement window. Together, rapid top-down control during retrieval suppression abolished cortical patterns of individual memories, and precipitated later forgetting. These findings reveal a precise chronometry on the voluntary suppression of individual memories.
Beyond faces: the contribution of the amygdala to visual processing in the macaque brain
Authors: Taubert Jessica , Wardle Susan G , Patterson Amanda , Baker Chris I 
Published: June 2024

Abstract
The amygdala is present in a diverse range of vertebrate species, such as lizards, rodents, and primates; however, its structure and connectivity differs across species. The increased connections to visual sensory areas in primate species suggests that understanding the visual selectivity of the amygdala in detail is critical to revealing the principles underlying its function in primate cognition. Therefore, we designed a high-resolution, contrast-agent enhanced, event-related fMRI experiment, and scanned 3 adult rhesus macaques, while they viewed 96 naturalistic stimuli. Half of these stimuli were social (defined by the presence of a conspecific), the other half were nonsocial. We also nested manipulations of emotional valence (positive, neutral, and negative) and visual category (faces, nonfaces, animate, and inanimate) within the stimulus set. The results reveal widespread effects of emotional valence, with the amygdala responding more on average to inanimate objects and animals than faces, bodies, or social agents in this experimental context. These findings suggest that the amygdala makes a contribution to primate vision that goes beyond an auxiliary role in face or social perception. Furthermore, the results highlight the importance of stimulus selection and experimental design when probing the function of the amygdala and other visually responsive brain regions.
Effect of heat treatment on positive electrode properties and crystal structures of Mo-modified MgMn2O4
Authors: Kitamura Naoto , Noritake Ryo , Ishibashi Chiaki , Idemoto Yasushi 
Published: June 2024

Abstract
MgMn2O4 (MMO) has attracted attention as a positive electrode material for magnesium rechargeable batteries. To improve the electrode properties, we performed modification of MMO with a Mo compound and investigated the effects of heat-treatment temperature (600 to 800 °C) of the modification process on the electrode properties and crystal structures. The Mo-modified MMO were successfully synthesized by immersing MMO in an aqueous solution containing Mo ion, followed by heat treatment. Discharge/charge cycle tests revealed that Mo-modified MMO heat-treated at 700 °C exhibited the highest discharge capacity and cycle characteristics. Crystal-structure analyses using synchrotron X-ray diffraction data showed that heat treatment at higher temperatures could relax the distortion of the crystal structure, although it increased the amount of Mg and Mn cation mixing. Crystal structure change and surface modification with a Mo compound are considered to be factors for improving positive electrode properties of MMO.
Synthesis and characterization of ligand-introduced [P2W12O44(C6H5PO3)2]10−
Authors: Take Shumpei , Minato Takuo , Sadakane Masahiro 
Published: June 2024

Abstract
Lacunary polyoxometalates represent a distinctive category of inorganic multidentate ligands that serve as precursors for building organic–inorganic hybrid materials and multinuclear metal oxo clusters. In this study, we successfully synthesized and characterized the organic–inorganic hybrid, [P2W12O44(C6H5PO3)2]10−. Two phenylphosphonato ligands were introduced at both ends of the vacant site to form the unique organic–inorganic–organic structure.
Quality of occlusal outcome in adult Class II patients treated with completely customized lingual appliances and Class II elastics compared to adult Class I patients
Authors: Janssens Yann , Foley Patrick F , Beyling Frauke , Stamm Thomas , Schwestka-Polly Rainer , Schmid Jonas Q 
Published: June 2024

Abstract

Objectives
The aim of this investigation was to evaluate whether Class II malocclusion in adult patients can be successfully corrected using a completely customized lingual appliance (CCLA) in combination with Class II elastics.

Methods
In order to detect differences in the final treatment outcome, two groups were matched for age and gender. Treatment results of 40 adult orthodontic patients with a Class I malocclusion (Group 1) were compared to 40 adults with a Class II malocclusion (Group 2). All patients had completed treatment with a CCLA (WIN, DW Lingual Systems, Bad Essen, Germany) without known centric occlusion—centric relation discrepancies, issues of compliance, or overcorrection in the individual treatment plan which was defined by a target set-up. In order to compare the treatment results of the two groups, 7 measurements using the American Board of Orthodontics Model Grading System (ABO MGS) and linear measurements for anterior-posterior (AP) and vertical dimensions were assessed at the start of lingual treatment (T1), after debonding (T2B) and compared to the individual target set-up (T2A).

Results
A statistically significant AP correction was achieved in Group 2 which represented 95% of the planned amount. The planned overbite correction was fully achieved in the Class I and Class II group. In both groups, there was a statistically significant improvement in the ABO scores, with no significant difference between the two groups at T2. 100% of the patients in Group 2 and 92.5% in Group 1 would meet the ABO standards after CCLA treatment.

Limitations
The main limitation of this study is that only patients who were wearing the elastics as prescribed were retrospectively included. Therefore, the results of this study may have limited generalizability.

Conclusions
Completely customized lingual appliances in combination with Class II elastics can correct a Class II malocclusion successfully in adult patients. The final treatment outcome can be of a similar high quality in Class I and Class II patients.
Non-coding RNA yREX3 from human extracellular vesicles exerts macrophage-mediated cardioprotection via a novel gene-methylating mechanism
Authors: Ciullo Alessandra , Li Liang , Li Chang , Tsi Kara , Farrell Colin , Pellegrini Matteo , Marbán Eduardo , Ibrahim Ahmed G E 
Published: June 2024

Abstract

Background and Aims
Extracellular vesicles (EVs) secreted by cardiosphere-derived cells exert immunomodulatory effects through the transmission of small non-coding RNAs.

Methods
The mechanism and role of yREX3, a small Y RNA abundant in EVs in myocardial injury, was investigated.

Results
yREX3 attenuates cardiac ischaemic injury by selective DNA methylation. Synthetic yREX3 encapsulated in lipid nanoparticles triggers broad transcriptomic changes in macrophages, localizes to the nucleus, and mediates epigenetic silencing of protein interacting with C kinase-1 (Pick1) through methylation of upstream CpG sites. Moreover, yREX3 interacts with polypyrimidine tract binding protein 3 (PTBP3) to methylate the Pick1 gene locus in a DNA methyltransferase–dependent manner. Suppression of Pick1 in macrophages potentiates Smad3 signalling and enhances efferocytosis, minimizing heart necrosis in rats with myocardial infarction. Adoptive transfer of Pick1-deficient macrophages recapitulates the cardioprotective effects of yREX3 in vivo.

Conclusions
These findings highlight the role of a small Y RNA mined from EVs with a novel gene-methylating mechanism.
Effectiveness of a continuous handwashing education program with multiple activities at a Japanese kindergarten school
Authors: Ueno Marie , Miyake Kimihiro , Shimada Hideaki , Tomokawa Sachi 
Published: June 2024

Abstract
Formation of proper handwashing techniques and habits from childhood is important for disease prevention. However, there are few studies that comprehensively and longitudinally evaluate the effectiveness of handwashing education for kindergarteners. This study aims to evaluate the effectiveness of continuous handwashing education using multiple activities to improve handwashing practices and skills among first- to third-grade students at a kindergarten in central Japan. A quasi-experimental one group pre- and post-test design was used. The education program consisted of three activities: (i) a 1-day teaching session by a researcher in January 2021, (ii) a 1-month follow-up activity led by kindergarten teachers and (iii) a 1-month follow-up activity led by parents at home, both occurring from late January to late February 2021. The study used questionnaires and handwashing skill experiments to investigate the kindergarteners’ handwashing practices and comprehensive handwashing skills (handwashing steps, handwashing time, rinsing time and areas of the hands left unwashed) before and after Activities 1, 2 and 3. Data were obtained from 56 kindergarteners (64.4%). Second and third graders showed a significant improvement in their handwashing practices after coughing or sneezing. With the exception of rinsing time, handwashing skills significantly improved in all grades after the 1-day teaching session. After 1-month follow-up activities, the number of areas left unwashed by first graders significantly decreased, and the score for handwashing steps significantly improved. This study indicated that continuous handwashing education is partially effective at improving and maintaining handwashing practices and skills, except for rinsing time, among kindergarteners of all grades.
CsMIKC1 regulates inflorescence development and grain production in Cannabis sativa plants
Authors: Xu Gencheng , Liu Yongbei , Yu Shuhao , Kong Dejing , Tang Kailei , Dai Zhigang , Sun Jian , Cheng Chaohua , Deng Canhui , Yang Zemao , Tang Qing , Li Chao , Su Jianguang , Zhang Xiaoyu 
Published: June 2024

Abstract
Female inflorescence is the primary output of medical Cannabis. It contains hundreds of cannabinoids that accumulate in the glandular trichomes. However, little is known about the genetic mechanisms governing Cannabis inflorescence development. In this study, we reported the map-based cloning of a gene determining the number of inflorescences per branch. We named this gene CsMIKC1 since it encodes a transcription factor that belongs to the MIKC-type MADS subfamily. Constitutive overexpression of CsMIKC1 increases inflorescence number per branch, thereby promoting flower production as well as grain yield in transgenic Cannabis plants. We further identified a plant-specific transcription factor, CsBPC2, promoting the expression of CsMIKC1. CsBPC2 mutants and CsMIKC1 mutants were successfully created using the CRISPR-Cas9 system; they exhibited similar inflorescence degeneration and grain reduction. We also validated the interaction of CsMIKC1 with CsVIP3, which suppressed expression of four inflorescence development-related genes in Cannabis. Our findings establish important roles for CsMIKC1 in Cannabis, which could represent a previously unrecognized mechanism of inflorescence development regulated by ethylene.
Isoliquiritigenin: a potential drug candidate for the management of erectile dysfunction
Authors: Saikia Queen , Adhikari Kamal , Sanjeev Airy , Hazarika Ajit , Sarma Kishore 
Published: June 2024

Abstract

Objective
This study aimed to assess the erectogenic properties of isoliquiritigenin taking sildenafil (SDF) as the standard.

Methods
The binding affinity of isoliquiritigenin (ISL) with the erectile marker proteins (endothelial nitric oxide synthase [eNOS] and enzyme phosphodiesterase type 5 [PDE5]) was investigated using Autodock Vina, which was validated using molecular dynamics simulation. Furthermore, the effect of ISL on the eNOS and PDE5 messenger ribonucleic acid (mRNA) expression and the sexual behavior of mice was investigated, along with the assessment of the pharmacokinetics of ISL.

Key findings
The results revealed that the binding affinity of ISL-eNOS/PDE5 and SDF-eNOS/PDE5 was in the range of −7.5 to −8.6 kcal/mol. The ISL-eNOS/PDE5 complexes remained stable throughout the 100 ns simulation period. Root mean square deviation, Rg, SASA, hydrogen, and hydrophobic interactions were similar between ISL-eNOS/PDE5 and SDF-eNOS/PDE5. Analysis of mRNA expressions in paroxetine (PRX)-induced ED mice showed that the co-administration of PRX with ISL reduced PDE5 and increased eNOS mRNA expression, similar to the co-administered group (PRX+SDF). The sexual behavior study revealed that the results of PRX+ISL were better than those of the PRX+SDF group. Pharmacokinetic evaluation further demonstrated that ISL possesses drug-like properties.

Conclusions
The results showed that ISL is equally potent as SDF in terms of binding affinity, specific pharmacological properties, and modulating sexual behavior.