bluuebunny/crossref_metadata_2025_split huggingface dataset:
Large electrostrain achieved in BNKT‐based ceramics by the adjustment of phase boundary with Ba(Sn0.70Nb0.24)O3 addition
Authors: Zheng Yazhong , Nie Huanghui , Feng Haoran , Chen Xinyu , Liu Xinyu , Qiu Qian , Zheng Ying , Yu Kun , Song Chunlin , Yan Yan , Jin Li , Liu Gang 
Published: May 2024

AbstractIn the current study, the incorporation of Ba(Sn0.70Nb0.24)O3 (BSN) effectively modifies the phase boundary of the 0.8(Bi0.50Na0.50)TiO3‐0.2(Bi0.50K0.50)TiO3 (BNKT) lead‐free ceramic material, inducing enhanced electrostrain properties at room temperature, particularly results in a “bud‐like” strain profile without negative strain. A comprehensive investigation has been conducted into the microstructure, electrical properties, and electrostrain properties of the above‐mentioned ceramics. The addition of BSN was observed to be well incorporated into the BNKT crystal structure, forming a single perovskite structure according to the X‐ray diffraction pattern. With the increase in BSN solid solution content, the temperature at which the transition from ferroelectric to the relaxor phase occurs shifted from 88.1°C to beneath room temperature (30°C). Specifically, the BNKT‐0.0075BSN ceramic demonstrated a positive strain response of 0.459% along with a large signal piezoelectric coefficient (d33*) of 643 pm/V. Additionally, the strain hysteresis of the BNKT‐0.0175BSN ceramics was only about 3% at 120°C. These experimental findings suggest that BNKT‐xBSN ceramics could be strong contenders for actuators and sensors, presenting promising opportunities for lead‐free ceramic actuator applications.
School‐based targeted prevention for children with mild intellectual disabilities or borderline intellectual functioning and behaviour problems: A pilot implementation study
Authors: Kühl E. , Deković M. , Thomaes S. , Koning I. , Liber J. M. 
Published: May 2024

AbstractBackgroundWe examined the implementation and potential effectiveness of a school‐based targeted prevention programme addressing behaviour problems, adapted for children with mild intellectual disabilities or borderline intellectual functioning.MethodThirteen children participated. The intervention was implemented in schools. We examined intervention dosage, reach, responsiveness, satisfaction, and comprehension, using questionnaires completed by children and trainers. We assessed child‐ and teacher‐reported behaviour problems before and after the intervention.ResultsTrainers selected both children who did and did not meet the intervention eligibility criteria, suggesting problems in intervention reach. Intervention dosage, responsiveness, satisfaction, and comprehension were satisfactory. There were group‐level behaviour problem decreases (i.e., Cohen's d). Individual‐level behaviour problem changes (i.e., Reliable Change Indices) showed large heterogeneity and little reliable change.ConclusionsThe results provide initial evidence that the intervention has potential for successful implementation in schools, but the current evidence for intervention effectiveness is inconclusive.
Association of atherosclerosis indices, serum uric acid to high‐density lipoprotein cholesterol ratio and triglycerides‐glucose index with hypertension: A gender‐disaggregated analysis
Authors: Ahari Rana Kolahi , Sahranavard Toktam , Mansoori Amin , Fallahi Zahra , Babaeepoor Negin , Ferns Gordon , Ghayour‐Mobarhan Majid 
Published: May 2024

AbstractThis study assessed the association between atherosclerosis indices, serum uric acid to high‐density lipoprotein cholesterol ratio (UHR) and triglyceride‐glucose (TyG) index and the prevalence of hypertension among MASHAD cohort participants. In this cross‐sectional study, the participants were divided into hypertensive and non‐hypertensive subjects. The atherosclerosis indices, UHR and TyG index of the two groups were compared. Logistic regression analyses were used to determine the associations of these indices with hypertension in both sex. Receiver operating characteristic (ROC) curve analysis was used to establish the cut‐off values for differentiating hypertensive from non‐hypertensive subjects. p‐values < .05 were considered statistically significant. Data related to 9675 subjects (3035 hypertensive and 6640 non‐hypertensive) were analyzed. The mean values of atherosclerosis indices, UHR and TyG index were significantly higher (p < .001) in the hypertensives compared to non‐hypertensives. After adjustment for potential confounders, among men, the TyG index (OR = 1.360; 95% CI: 1.210–1.530; p < .001) remained an independent factor for hypertension. Among women, atherogenic index of plasma (OR = 1.005; 95% CI: 1.002–1.007; p < .001), UHR (OR = 1.043; 95% CI: 1.026–1.060; p < .001) and TyG index (OR = 1.519; 95% CI: 1.376–1.677; p < .001) remained independent factors for hypertension. ROC curve analysis revealed that compare to the other indices, TyG index had a better predictive value for hypertension in both sex, especially in women.
Exploring the immune escape mechanisms in gastric cancer patients based on the deep AI algorithms and single‐cell sequencing analysis
Authors: Chen Wenli , Liu Xiaohui , Wang Houhong , Dai Jingyou , Li Changquan , Hao Yanyan , Jiang Dandan 
Published: May 2024

AbstractGastric cancer is a prevalent and deadly malignancy, and the response to immunotherapy varies among patients. This study aimed to develop a prognostic model for gastric cancer patients and investigate immune escape mechanisms using deep machine learning and single‐cell sequencing analysis. Data from public databases were analysed, and a prediction model was constructed using 101 algorithms. The high‐AIDPS group, characterized by increased AIDPS expression, exhibited worse survival, genomic variations and immune cell infiltration. These patients also showed immunotherapy tolerance. Treatment strategies targeting the high‐AIDPS group identified three potential drugs. Additionally, distinct cluster groups and upregulated AIDPS‐associated genes were observed in gastric adenocarcinoma cell lines. Inhibition of GHRL expression suppressed cancer cell activity, inhibited M2 polarization in macrophages and reduced invasiveness. Overall, AIDPS plays a critical role in gastric cancer prognosis, genomic variations, immune cell infiltration and immunotherapy response, and targeting GHRL expression holds promise for personalized treatment. These findings contribute to improved clinical management in gastric cancer.
Prognostic value of CDKN2A in head and neck squamous cell carcinoma via pathomics and machine learning
Authors: Wang Yandan , Zhou Chaoqun , Li Tian , Luo Junpeng 
Published: May 2024

AbstractThis study aims to enhance the prognosis prediction of Head and Neck Squamous Cell Carcinoma (HNSCC) by employing artificial intelligence (AI) to analyse CDKN2A gene expression from pathology images, directly correlating with patient outcomes. Our approach introduces a novel AI‐driven pathomics framework, delineating a more precise relationship between CDKN2A expression and survival rates compared to previous studies. Utilizing 475 HNSCC cases from the TCGA database, we stratified patients into high‐risk and low‐risk groups based on CDKN2A expression thresholds. Through pathomics analysis of 271 cases with available slides, we extracted 465 distinctive features to construct a Gradient Boosting Machine (GBM) model. This model was then employed to compute Pathomics scores (PS), predicting CDKN2A expression levels with validation for accuracy and pathway association analysis. Our study demonstrates a significant correlation between higher CDKN2A expression and improved median overall survival (66.73 months for high expression vs. 42.97 months for low expression, p = 0.013), establishing CDKN2A's prognostic value. The pathomic model exhibited exceptional predictive accuracy (training AUC: 0.806; validation AUC: 0.710) and identified a strong link between higher Pathomics scores and cell cycle activation pathways. Validation through tissue microarray corroborated the predictive capacity of our model. Confirming CDKN2A as a crucial prognostic marker in HNSCC, this study advances the existing literature by implementing an AI‐driven pathomics analysis for gene expression evaluation. This innovative methodology offers a cost‐efficient and non‐invasive alternative to traditional diagnostic procedures, potentially revolutionizing personalized medicine in oncology.
Optimizing maintenance therapy in responders to abrocitinib induction: A post hoc analysis of JADE REGIMEN
Authors: Thyssen J. P. , Silverberg J. I. , Ruano J. , Blauvelt A. , Gubelin W. , Simpson E. L. , Weidinger S. , Valdez H. , Terry K. K. , Biswas P. , Güler E. , Feeney C. 
Published: May 2024

AbstractBackgroundTreatment optimization may require dosing flexibility. The Phase 3 JADE REGIMEN trial (NCT03627767) evaluated maintenance of abrocitinib 200 mg‐induced response in patients with moderate‐to‐severe atopic dermatitis (AD) randomly assigned to subsequent maintenance with continuous‐dose abrocitinib (200 mg), reduced‐dose abrocitinib (100 mg) or placebo. Maintenance with continuous‐dose abrocitinib was associated with a stronger prevention of disease flares, but also with a higher occurrence of adverse events, compared with the reduced dose.ObjectiveThis post hoc analysis of JADE REGIMEN aimed to identify predictors of not flaring during the maintenance period and to generate tools that can be used to assess probability of not flaring.MethodsData were analysed from patients who responded to abrocitinib 200 mg induction therapy (12 weeks) and were randomly assigned to receive abrocitinib (200 mg or 100 mg) or placebo in the 40‐week maintenance period. Demographic and baseline disease characteristics and level of response to induction were evaluated for association with not flaring using logistic regression. Parameters with a significant (p < 0.15) interaction with the treatment arm were fitted into a multivariable regression model, which was used to assess probability of not flaring.ResultsLower percentage body surface area affected at baseline (p = 0.09), absence of prior exposure to systemic agents (p = 0.02) and greater percentage change in EASI from baseline to randomization (p < 0.001) were identified as predictors of not flaring with abrocitinib. In both abrocitinib arms, percentage change in EASI from baseline to end of induction (Week 12) was the major contributor to the probability of not flaring in the maintenance period.ConclusionsMaintenance of response using reduced‐dose abrocitinib 100 mg may be feasible for patients with lower baseline disease severity and strong response to abrocitinib 200 mg induction treatment.
Pollination and pollen plant diversity by Apis cerana cerana during olive flowering based on DNA metabarcoding
Authors: Liu Wenping , Huang Sicheng , Hao Youjin , Long Jingui , Wang Yamei , Jin Zhiwei , Lu Huanhuan , Zhou Zeyang , Dang Xiaoqun , Pan Zhaohui , Huang Dunyuan 
Published: May 2024

AbstractTo understand the role of Apis cerana cerana in olive tree (Olea europaea L.) pollination, pollinators and pollen carried by bees were collected from 11 experimental plots during the flowering period. The abundance and diversity of pollen plant species were investigated using DNA metabarcoding. A total of 583 pollinators were collected and A. cerana cerana accounts for 46.83%. Further analysis revealed a total of 56 families, 136 genera and 195 plant species in bee pollens. O. europaea is the dominant species accounting for 42.02 ± 34.89% and then followed by Sedum japonicum (8.70 ± 16.42%). Diversity index showed that the abundance and diversity of pollen plant species were the highest in Wanzhou (WZ) and lowest in Hechuan (HC). This suggests that Wanzhou sample plot has a greater abundance of plant species to supplement the bee diet. Excessive presence of miscellaneous flowering plants in olive plantations can distract bees from collecting olive tree pollens. Therefore, their abundances can be reduced appropriately while ensuring food diversity for the bees. Based on the abundance of plants in pollens, we recommend that appropriately planting of S. japonicum, Youngia japonica and Vicia villosa in olive plantations with fewer flowering plants could be an effective supplement of bee food. Our results not only contribute to future studies on olive tree pollination but also provide new ideas for enriching flowering plants in or around olive plantations.
Tagging mortality in acoustic telemetry studies: Insights from a multispecies analysis
Authors: Martínez‐Ramírez Lucas , Bentes Luis , Dias André , Erzini Karim , Gandra Miguel , Kraft Sebastian , Winkler Alexander C. , Abecasis David 
Published: May 2024

AbstractThe widespread adoption of acoustic telemetry has transformed our understanding of marine species' behavior and movement ecology. However, accurately interpreting telemetry data, especially concerning tagging mortality, is essential for drawing valid conclusions. In this study, we scrutinized tagging mortality in 223 individuals across 14 species and evaluated the impact of tagging methodologies, including capture method and size effects. Results reveal high tagging survival rates overall, attributable to the resiliency of the studied species and the rigorous animal welfare protocols followed during tagging procedures. Our results highlight the importance of tailoring array designs to the specific mobility patterns of the studied species for accurate survival assessments. This research contributes to generalizing mortality assessments and clearing the path for more precise and reliable telemetry studies in the future.
Directors with foreign experience and employee protection
Authors: Zu Chunyu 
Published: May 2024

AbstractThis study investigates the impact of managerial foreign experience on corporate employee protection. Using 30,644 firm‐year observations from 3972 Chinese listed firms from 2008 to 2020, I find that compared with firms without returnee directors, firms with returnee directors pay more social insurance premiums and implement better employee treatment policies. The positive relationship is stronger when returnee directors acquire foreign work experience (as opposed to educational experience), gain experience in countries with strong labor protection, serve as a CEO or a chairperson in the Chinese firm, and have high media visibility. The cross‐sectional analysis shows the effect of directors with foreign experience on employee protection is greater in non‐state‐owned firms, and returnee directors improve employee protections more when the employees have relatively weak discourse power. Additional analysis finds that returnee directors improve employee training and occupational safety, and they help balance social insurance generosity and employment levels. The results are robust after addressing the potential endogeneity problems. My results suggest a potential way to transfer better labor protection practices from developed to emerging markets.
A practical guide to bioimaging research data management in core facilities
Authors: Schmidt Christian , Boissonnet Tom , Dohle Julia , Bernhardt Karen , Ferrando‐May Elisa , Wernet Tobias , Nitschke Roland , Kunis Susanne , Weidtkamp‐Peters Stefanie 
Published: May 2024

AbstractBioimage data are generated in diverse research fields throughout the life and biomedical sciences. Its potential for advancing scientific progress via modern, data‐driven discovery approaches reaches beyond disciplinary borders. To fully exploit this potential, it is necessary to make bioimaging data, in general, multidimensional microscopy images and image series, FAIR, that is, findable, accessible, interoperable and reusable. These FAIR principles for research data management are now widely accepted in the scientific community and have been adopted by funding agencies, policymakers and publishers. To remain competitive and at the forefront of research, implementing the FAIR principles into daily routines is an essential but challenging task for researchers and research infrastructures. Imaging core facilities, well‐established providers of access to imaging equipment and expertise, are in an excellent position to lead this transformation in bioimaging research data management. They are positioned at the intersection of research groups, IT infrastructure providers, the institution´s administration, and microscope vendors. In the frame of German BioImaging – Society for Microscopy and Image Analysis (GerBI‐GMB), cross‐institutional working groups and third‐party funded projects were initiated in recent years to advance the bioimaging community's capability and capacity for FAIR bioimage data management. Here, we provide an imaging‐core‐facility‐centric perspective outlining the experience and current strategies in Germany to facilitate the practical adoption of the FAIR principles closely aligned with the international bioimaging community. We highlight which tools and services are ready to be implemented and what the future directions for FAIR bioimage data have to offer.
Using interviewee‐created graphs to explore the arc of closeness and trust in adolescents' supportive relationships with nonparental adults
Authors: Griffith Aisha N. 
Published: May 2024

AbstractAdolescents' supportive relationships with nonparental adults are beneficial when they are close and have trust, but few studies explore how adolescents believe closeness and trust unfold over time. I propose a method for prompting adolescents to retrospectively describe the development of abstract components of such relationships by sharing a study that used interviewee‐created graphing to prompt adolescents to move from concrete parts of the relationship to abstract concepts using a tool adolescents would be familiar with from math classes. Analyses using Venn diagrams and matrices suggested adolescents conceptualized closeness and trust differently, however, this was shaped by whether the adult was a part of their family. Reflections on how the proposed graphing method can effectively be used will be discussed.
Comparing the efficacy of 308‐nm light‐emitting diode and 308‐nm excimer lamp for treating vitiligo: A randomized controlled trial
Authors: Hu Yu , Liu Lihao , Xu Zhuohong , Huang Dan , Chen Hongying , Zhang Jiaan , Chen Lihao , Dai Xiaoxi , Zhang Liangliang , Luan Chao , Ju Mei , Chen Kun 
Published: May 2024

AbstractBackgroundIn previous studies, the 308‐nm light‐emitting diode (LED) has been proven safe and effective for treating vitiligo. However, direct comparisons between the 308‐nm LED and 308‐nm excimer lamp (308‐nm MEL) for the treatment of vitiligo are lacking.ObjectiveTo compare the efficacy of the 308‐nm LED and 308‐nm MEL for treating nonsegmental stable vitiligo.Patients and MethodsThis randomized controlled trial was conducted between January 2018 and August 2023. Enrolled patients were randomly assigned to either the 308‐nm LED or the 308‐nm MEL groups, both receiving 16 treatment sessions. Adverse events that occurred during the treatment were documented.ResultsIn total, 269 stable vitiligo patches from 174 patients completed the study. A total of 131 lesions were included in the 308‐nm LED group, and 138 lesions were included in the 308‐nm MEL group. After 16 treatment sessions, 38.17% of the vitiligo patches in the 308‐nm LED group achieved repigmentation of at least 50% versus 38.41% in the 308‐nm MEL group. The two devices exhibited similar results in terms of efficacy for a repigmentation of at least 50% (p = .968). The incidence of adverse effects with the two phototherapy devices was comparable (p = .522).ConclusionsTreatment of vitiligo with the 308‐nm LED had a similar efficacy rate to the 308‐nm MEL, and the incidence of adverse effects was comparable between the two devices.
Conquering new grounds: plant organellar C‐to‐U RNA editing factors can be functional in the plant cytosol
Authors: Thielen Mirjam , Gärtner Béla , Knoop Volker , Schallenberg‐Rüdinger Mareike , Lesch Elena 
Published: May 2024

SUMMARYPlant mitochondrial and chloroplast transcripts are subject to numerous events of specific cytidine‐to‐uridine (C‐to‐U) RNA editing to correct genetic information. Key protein factors for this process are specific RNA‐binding pentatricopeptide repeat (PPR) proteins, which are encoded in the nucleus and post‐translationally imported into the two endosymbiotic organelles. Despite hundreds of C‐to‐U editing sites in the plant organelles, no comparable editing has been found for nucleo‐cytosolic mRNAs raising the question why plant RNA editing is restricted to chloroplasts and mitochondria. Here, we addressed this issue in the model moss Physcomitrium patens, where all PPR‐type RNA editing factors comprise specific RNA‐binding and cytidine deamination functionalities in single proteins. To explore whether organelle‐type RNA editing can principally also take place in the plant cytosol, we expressed PPR56, PPR65 and PPR78, three editing factors recently shown to also function in a bacterial setup, together with cytosolic co‐transcribed native targets in Physcomitrium. While we obtained unsatisfying results upon their constitutive expression, we found strong cytosolic RNA editing under hormone‐inducible expression. Moreover, RNA‐Seq analyses revealed varying numbers of up to more than 900 off‐targets in other cytosolic transcripts. We conclude that PPR‐mediated C‐to‐U RNA editing is not per se incompatible with the plant cytosol but that its limited target specificity has restricted its occurrence to the much less complex transcriptomes of mitochondria and chloroplast in the course of evolution.
Cultural variation in New Zealand English stories about place
Authors: Degani Marta , Onysko Alexander 
Published: May 2024

AbstractThis study is set in the context of Aotearoa New Zealand and investigates the influence of cultural knowledge on the type of topics that speakers of New Zealand Englishes (NZEs) associate to in their narrations. A storytelling task based on picture prompts of New Zealand landscapes shows a major difference between the cultural associations of Māori and Pākehā (New Zealand European) participants. The difference can be captured in two cultural frames that underlie the preferred topics chosen by the two groups. The findings are discussed in terms of their implications for defining NZEs, and they also bear ramifications for theory development in Cultural Linguistics, highlighting the nested and flexibly construable nature of cultural conceptualisations. For research on world Englishes, the study is an example of how cultural‐linguistic analyses can be extended towards larger cultural framings to explain cultural variation among speakers of Englishes.