bluuebunny/crossref_metadata_2025_split huggingface dataset:
Online Version of the Self-Administered Food Frequency Questionnaire for the Iranian Adult Population
Authors: Morvaridi Mehrnaz , Karandish Majid , Bazyar Hadi , Rasekhi Hamid , Bavi Behbahani Hossein 
Published: February 2025

Background: With the growing accessibility of the internet, dietary assessment tools, including food frequency questionnaires (FFQs), are increasingly being adapted for web platforms. A web-based FFQ was developed as a dietary assessment tool for healthy adults in Iran. Objective: This study aimed to develop an online FFQ for dietary data collection among Iranian adults and to compare its performance with the validated Iranian printed FFQ. Methods: Eligible participants were randomly assigned to complete both the printed and web-based FFQs. The type of FFQ alternated for each participant after 10 days. The agreement between the two FFQs was assessed using the Bland-Altman method and correlation analysis. Results: Of the 190 participants, final analyses were conducted on 141 individuals, including 70 females (49.6%) and 71 males (50.4%) who completed both FFQs. Agreement was high for all nutrient intakes ( r > .8). Among food groups, “Whole grains” showed the highest correlation ( r = .84), while “Potato” had the lowest ( r = .25). There were no significant differences in the time taken to complete the questionnaires. Conclusion: The web-based FFQ demonstrated strong agreement with the validated printed FFQ, accurately reflecting nutrient and food group intakes in Iranian adults.
Understanding another person’s story: Using personal, community, global, and universal narratives to teach arts and humanities
Authors: Cochran Maria Eichmans , Burnett Rebecca E 
Published: February 2025

Narratives help situate arts and humanities—exploring the creation of artifacts as well as providing space for making sense of the world. Narratives can preserve the original context as well as recontextualize art in light of contemporary political and social issues. Personal, community, global, and universal narratives can make art more accessible and memorable to students. Four well-known pieces of art created over 550 years serve as models for ways narratives can be the focus of teaching arts and humanities to encourage engagement, comprehension, retention, and memory.
Role of Dolutegravir-based antiretroviral treatment in achieving an undetectable HIV-1 viral load among women attending prevention of mother-to-child transmission clinics in Addis Ababa, Ethiopia
Authors: Woldesemayat Belete , Getaneh Yimam , Adane Sisay , Yizengaw Ajanaw , Yilma Amelework , Araya Haile Shambel , Zealiyas Kidist 
Published: February 2025

Objectives: This study aimed to determine the prevalence of detectable HIV-1 viral load and associated factors among pregnant and lactating women on Dolutegravir-based and non-Dolutegravir-based regimens. Methods: HIV-positive pregnant and breastfeeding women enrolled in a cross-sectional study design incorporating Dolutegravir versus non-Dolutegravir group for comparison purposes, and the study was conducted from September 2022 to March 2023. In total, 684 women receiving antiretroviral treatment (456 on Dolutegravir-based and 228 on non-Dolutegravir-based regimens) were enrolled across 16 prevention of mother-to-child transmission clinics. An undetectable viral load was defined as <20 RNA copies/mL. Univariable and multivariable regression models were used to determine the associations of the detectable viral load with factors such as sociodemographic, clinical, obstetric, and laboratory parameters. Results: The prevalence of detectable viral load on a non-Dolutegravir-based regimen was 32.9% and on a Dolutegravir-based regimen group was 19.7%. The overall prevalence was 24.1% (95% CI: 20.9–27.6). Compared with non-Dolutegravir-based regimens, Dolutegravir-based regimens were associated with 69% (AOR: 0.31; 95% CI: 0.16–0.61) lower risk of having a detectable viral load. The median viral load was significantly lower in women on a Dolutegravir-based regimen (1.66 log copies/mL) compared to those on a non-Dolutegravir-based regimen (2.11 log copies/mL; p < 0.001). A lower level of adherence was associated with 2.33 times (AOR: 2.33; 95% CI: 1.06–5.12) higher odds of having a detectable viral load and women who had a WHO clinical stage II and above were 2.71 times (AOR: 2.71: 95% CI: 1.30–5.64) more vulnerable to developing a detectable viremia than their counterparts. Conclusion: Despite the scale-up of Dolutegravir-based regimens, the overall prevalence of detectable viremia was 24.1%, with a higher prevalence of 32.9% among women on non-Dolutegravir-based regimens indicating a programmatic challenge that could affect mother-to-child transmission outcomes. Strengthening adherence monitoring and maintaining World Health Organization clinical stage I is crucial for achieving undetectable viral load levels in pregnant and breastfeeding women.
The association between adaptability and the symptoms of depression and anxiety in early adolescents: a network analysis in a longitudinal design
Authors: Lu Gangyuan , Zhu Linfei , Huang Rongqian , Lai Pengcheng , Wang Chao 
Published: February 2025

Abstract

Background
The co-occurrence of depression and anxiety is relatively more common among adolescents. Emerging evidence suggests that adaptability might affect this phenomenon. Network analysis can provide insight into the dynamics between symptoms of mental disorders. Therefore, we used network analysis 1) to explore symptom networks and 2) to investigate the association between adaptability and symptoms based on a longitudinal design.

Methods
833 Chinese adolescents (449 males and 384 female) were recruited, with adaptability, depressive and anxiety symptoms measured at T1, 426 of them were followed up one year later at T2. Symptom networks were constructed for all participants and for the two groups based on their adaptability scores at T1. Furthermore, mediation analysis was performed to examine the relationship between adaptability and bridge symptoms at both timepoints.

Results
Irritable and Guilty showed the highest expected value at T1 (p < 0.05). The high adaptability group’s symptom network (HGN) was less connected than the low adaptability group’s symptom network (LGN) (p < 0.001). Furthermore, Irritable (T1) and adaptability (T2) were sequential mediators (p < 0.001) between adaptability (T1) and Irritable (T2).

Conclusions
These findings suggest that adaptability might affect the network dynamics, underscoring its importance to the occurrence of depression and anxiety among adolescents. Irritable and Guilty being the bridge symptoms may indicate the interventions to target in adolescents with comorbid depression and anxiety.
Pre-departure PCR testing of travellers for SARS-CoV-2 was an effective tool in limiting transmission in Greenland during the early phases of the COVID-19 pandemic
Authors: Møller Mie , Moestrup Kasper Sommerlund , Abelsen Trine , Vedsted Peter , Mølbak Kåre , Koch Anders 
Published: February 2025

Abstract

Background
During the early part of the COVID-19 pandemic, travel restrictions were implemented in Greenland to contain SARS-CoV-2 transmission. Despite their widespread use, empirical evidence supporting the effectiveness of travel restrictions is scarce. Greenland was in a unique position to maintain pre-departure testing among travellers, and we aimed to describe the effectiveness of pre-departure testing to inform the implementation of travel restrictions in future outbreaks.

Methods
Our analysis included SARS-Cov-2 PCR test results from travellers, including children, arriving in Greenland from Denmark between June 15, 2020, and January 26, 2022. Additionally, we identified positive tests performed within 14 days post-arrival to Greenland in this population. We estimated the sensitivity of pre-departure screening by dividing the number of positive cases identified pre-departure by the sum of cases identified pre-departure and within 14 days post-arrival in Greenland.

Results
Our analysis covered around 43% of all travellers who underwent pre-departure screening. Out of 26,406 SARS-CoV-2 PCR tests, the proportion of positive tests was 0.6%, which varied over time according to the incidence in Denmark. Overall sensitivity of pre-departure screening was 59% and decreased over time, reaching a minimum of 36% in January 2022. The overall proportion of positive PCR post-arrival tests among all travellers was 0.4%.

Conclusions
Implementing pre-departure PCR testing for SARS-CoV-2 among travellers can be effective in the early stages of outbreaks, particularly in geographical regions like Greenland where community transmission had not yet occurred. Our findings suggest that pre-departure screening of travellers contributed to delaying community transmission in Greenland compared to most other countries, thereby reducing the COVID-19 disease burden.
Access to health services by women subjected to violence: findings from administrative healthcare data from the metropolitan area of northern Italy
Authors: Gabellini Eliana , Salvatori Andrea , Greco Maria Teresa , Cattaneo Cristina , Tambuzzi Stefano , Costantino Maria Antonella , Russo Antonio Giampiero 
Published: February 2025

Abstract

Background
In Italy, approximately 50% of women report experiencing episodes of psychological and/or physical violence. The Emergency Department (ED) is widely recognized as one of the health services to which victims of violence seek treatment for injuries and within which situations of domestic violence and abuse can be recognized. This work aims to estimate the phenomenon of violence in the population of the Health Protection Agency (ATS) of Milan using data from emergency room access and hospital admissions. A further goal of the survey is to provide evidence to launch audit processes in health units designed to foster improvement strategies for the management of the phenomenon and guarantee integration with anti-violence centers.

Methods
In the first phase of the project, an algorithm was designed to detect women subjected to violence intercepted in the five years 2019–2023 in the administrative healthcare data of emergency rooms and hospital admissions. To identify the cases, the specific diagnosis codes of the ICD-9 have been selected. Prevalence and time trends of the phenomenon were estimated, stratifying by different socioanagraphic characteristics and by types and attributes of access.
In addition, the degree of integration between social and health services was analyzed. The areas researched concern intake by specialized services; specifically, data on female residents of the cohort were cross-referenced with data on access to the network of social health services in the ATS territory.

Results
A clearly increasing phenomenon emerges: from 2019 to 2023, admissions to the ED have risen by 17%. A total of 35.6 percent of admissions involve women between the ages of 18 and 34. Foreigners account for approximately 40.9 percent of the cohort while constituting 15 percent of women residing in the territory. The yellow (Urgency) triage code is assigned for 3 out of the 4 admissions. A total of 11.5% of women had multiple accesses.

Conclusions
Administrative healthcare data offer consistent data for studying the phenomenon of violence. This project aims to provide useful tools to better guide policies for intervention and integration between services in the area. Further reflection will focus on the possibility of integrating health and social services to support an integrated approach.
Designing equitable telehealth solutions for outpatient surgical care in a safety-net population: a human-centered design approach
Authors: Chehab Lara Z. , Mettupalli Diyah , Cevallos Jenny R. , Rogine Camille , Sammann Amanda , Kumar Sandhya 
Published: February 2025

Abstract

Background
The SARS CoV-2 (COVID-19) pandemic catalyzed a dramatic shift in healthcare delivery, with telemedicine emerging as a common mode of care provision. While pre-pandemic telemedicine services were more commonly used for preventive visits and had better adherence among younger and more affluent demographics, the landscape of telehealth in the post-pandemic period has shifted significantly to include surgical visits and publicly-insured patient populations. Without specific insights from patients and clinicians to guide this transition, telehealth delivery risks exacerbating disparities in access, experience and outcomes for medically underserved populations.

Methods
We utilized a human-centered design (HCD) approach to gain insights into patient and clinician perspectives on telehealth delivery at a surgical outpatient clinic in an urban safety-net hospital and level 1 trauma center. During the Inspiration phase of HCD, we conducted 19 in-depth interviews with patients and surgical clinicians, and applied a combined thematic analysis and design synthesis approach to identify key insight statements representing actionable tensions across cohorts. During the Ideation phase of HCD, we held a structured brainstorming session to identify solutions and facilitated a discussion with surgical faculty to co-design and refine a prototype.

Results
Interview analysis revealed 12 main themes, which were then reorganized into 5 core insights across both groups: “In-person appointments can be resource intensive for patients, making their attendance costly in more ways than one”; “When sacrificing connection for convenience, telehealth exacerbates discrimination felt by historically marginalized patients”; “Personal interactions are crucial for establishing new relationships and repairing mistrust between patients and clinicians”; “Visual cues and non-verbal communication are essential for personalized and effective surgical care”; “Patients and clinicians value the human infrastructure built into the in-person visit experience.” Brainstorming participants generated ideas from the first insight statement. Subsequent prototyping and co-design sessions led to the development of a screening prototype allowing both clinic staff and patients to book telehealth appropriate appointments.

Conclusions
This study offers a HCD approach to developing insights and tailoring health service interventions to the local contexts for safety-net providers. By understanding the unique needs and preferences of underserved populations, we can develop telehealth interventions that increase adoption and ensure equitable access to care.
Mitigating HIV risk associated with widow cleansing and wife inheritance using combined biomedical and structural interventions in western Kenya: a mathematical modeling study
Authors: Gathungu Duncan K. , Ojiambo Viona N. , Kimathi Mark E. , Kaftan David , Kim Hae-Young , Citron Daniel T. , Platais Ingrida , Briedenbecker Daniel , Kirkman Clark , Mwalili Samuel M. , Bershteyn Anna 
Published: February 2025

Abstract

Background
In parts of Africa, women who become widowed lose housing, bank accounts, and other property and must re-marry to avoid extreme poverty. To re-marry, some women are required to undergo widow “cleansing”—condomless sex with a man who removes “impurities” ascribed to her from her husband’s death—and are “inherited” as a wife of a brother-in-law. This study explores how HIV biomedical and structural interventions could reduce HIV-related harms associated with these practices.

Methods
We adapted EMOD-HIV, an HIV agent-based network transmission model previously calibrated and validated for the Nyanza region of western Kenya. Building on the model’s pre-existing configuration of marriages, mortality, and widowhood, we added widow cleansing and wife inheritance with assumptions based on literature. Modeled HIV prevalence among inherited widows was validated to match observed data. We modeled the effect of widowed women, cleansers, and inheritors receiving biomedical HIV interventions (testing, treatment for those tested positive, and 1 year of pre-exposure prophylaxis (PrEP) initiated at cleansing for those tested negative) with or without structural interventions (female empowerment). We modeled low (30%) and high (70%) intervention uptake and reported HIV outcomes including cumulative infections over 2025–2050.

Results
Modeled HIV prevalence among inherited widowed women was 59.8% (95% CI: 59.5–60.2%), comparable to observed prevalence of 64.1% (95% CI: 63.2–65.4%). Among all widowed women, biomedical interventions averted 2.0% (95% CI: 1.3–2.6%) of HIV infections with low uptake and 2.6% (95% CI: 2.0–3.2%) with high uptake. Combined biomedical and structural interventions averted 7.8% (95% CI: 7.2–8.4%) of HIV infections with low uptake and 16.1% (95% CI: 15.5–16.6%) with high uptake. Impacts were smaller for men, e.g., high-uptake structural and biomedical interventions averted 1.8% (95% CI: 1.5–2.2%) of infections among cleansers and 2.7% (95% CI: 2.4–3.0%) among inheritors.

Conclusions
Widowed women are a vulnerable population with extremely high HIV prevalence. Combined biomedical and structural interventions focused on the practice of widow cleansing and wife inheritance have the potential to avert up to one-quarter of HIV infections among widowed women, and a smaller proportion among men participating in these practices.
The preventive effect and mechanism of Tibetan medicine Aconitum tanguticum (Maxim.) Stapf on acute lung injury
Authors: Meng Xiang , Liu Yu-Peng , Dai Jia-Wei , Bai Yuan , Hu Xin , Azhar Muhammad , Huang Xian-Ju 
Published: February 2025

Abstract

Ethnopharmacological relevance

Aconitum tanguticum (Maxim.) Stapf (ATS) is a rare Tibetan medicinal plant that belongs to the Ranunculaceae family. This herb is mainly distributed in the high-altitude areas of Qinghai, Gansu provinces, and Tibetan Autonomous Region in China. In Tibetan medicine, ATS is mainly used to treat lung inflammation, hepatitis, gastrointestinal diseases, influenza, fever caused by infectious diseases, food poisoning, snake and scorpion bites, and yellow water disease. ATS has anti-inflammatory, antiviral, and other pharmacological effects, according to recent research. It is welltolerated by individuals from diverse ethnic groups and has a long history of use in Tibetan medicine.

Aim of the study
This study investigated the preventive effects of ATS alcoholic extract on acute lung injury (ALI) in mice and aimed to elucidate its possible mechanism of action.

Materials and methods
Alveolar epithelial cells A549 and specific pathogen-free C57BL/6 mice were induced with lipopolysaccharide (LPS) to establish ALI models both in vivo and in vitro and to explore the pharmacological effects and therapeutic mechanisms of ATS.

Results
ATS down-regulated the mRNA levels of inflammatory factors NF-κB p65, TNF-α, IL-1β, and IL-8, inhibited the release of reactive oxygen species, inhibited epithelial-mesenchymal transition caused by sustained cell injury, promoted the Keap1/Nrf2/HO-1 signalling pathway, reduced the degree of oxidative stress in vivo, and inhibited the production of proteins associated with LPS-induced ferroptosis.

Conclusion
The Tibetan medicine ATS reduced pulmonary haemorrhage and oedema in ALI mice, alleviated the degree of lung tissue lesions, inhibited the expression of inflammatory factors and apoptosis, and plays a preventive role against acute lung injury in mice.

Graphical Abstract
A scoping review of factors influencing the implementation of liquid biopsy for cancer care
Authors: Sheriff Samran , Saba Maree , Patel Romika , Fisher Georgia , Schroeder Tanja , Arnolda Gaston , Luo Dan , Warburton Lydia , Gray Elin , Long Georgina , Braithwaite Jeffrey , Rizos Helen , Ellis Louise Ann 
Published: February 2025

Abstract

Background
Liquid biopsy (LB) offers a promising, minimally invasive alternative to traditional tissue biopsies in cancer care, enabling real-time monitoring and personalized treatment. Despite its potential, the routine implementation of LB in clinical practice faces significant challenges. This scoping review examines the barriers and facilitators influencing the implementation of liquid biopsies into standard cancer care.

Methods
Four academic databases (PubMed, Scopus, Embase, and Web of Science) were systematically searched without language restrictions. We included peer-reviewed articles that were published between January 2019 and March 2024 that focused on the implementation of LB in cancer care or described barriers and facilitators to its implementation. Data relevant to the review objective, including key article characteristics; barriers and facilitators of implementation; and recommendations for advancement or optimisation; were extracted and analysed using thematic and visual network analyses.

Results
The majority of the included articles were narrative review articles (84%), with most from China (24.2%) and the United States (20%). Thematic analysis identified four main categories and their associated barriers and facilitators to the implementation of LB in cancer care: (1) Laboratory and personnel requirements; (2) Disease specificity; (3) Biomarker-based liquid biopsy; and (4) Policy and regulation. The majority of barriers identified were concentrated in the pre-analytical phase, highlighting the lack of standardization in LB technologies and outcomes.

Conclusions
Through a thematic analysis of the barriers and facilitators to LB implementation, we present an integrated tool designed to encourage the standardization of testing methods for clinical practice guidelines in the field.
Anti-glycaemic effect of the Chinese modified DASH diet combined with 23% low-sodium salt in patients with hypertension and type 2 diabetes: a clinical trial
Authors: An Jiaxian , Liu Guowei , Luo Wenjun , Zhou Xiaomeng , Mei Ying , Zhang Ziyan , Zhao Li , Huang Yao , Mu Lihong 
Published: February 2025

Abstract

Background
Although many previous trials have formalized the blood glucose-lowering effect of the DASH diet, relevant reports in China remain limited. This study aimed to explore the anti-hyperglycaemic effect of the Chinese Modified Dietary Approaches to Stop Hypertension diet combined with 23% low-sodium salt and meal packs in patients with hypertension and type 2 diabetes.

Methods
We conducted a randomized controlled single-blinded trial with a semi-open design; 100 participants were randomly assigned to Group A (control), Group B (23% low-sodium salt), and Group C (meal packs) for 8 weeks of dietary intervention. All participants were followed up weekly to collect glycaemia data (standardized meal tolerance test), salt use, and adverse events.

Results
Generalized estimating equation analysis indicated that fasting blood glucose decreased in all three groups following the intervention when compared to baseline. Group A decreased by 0.72 mmol/L (P = 0.008), while Groups B and C decreased by 2.02 mmol/L and 2.06 mmol/L, respectively (both P < 0.001). Although the latter two groups experienced greater reductions than Group A, the differences among the groups were not statistically significant (P = 0.450). For postprandial blood glucose, Group C showed the most pronounced decrease. The three groups recorded reductions of 2.43 mmol/L, 2.52 mmol/L, and 4.29 mmol/L, respectively (all P < 0.001), with again no significant difference observed between the groups (P = 0.088). The most notable enhancement in postprandial glucose was observed in Group C, which demonstrated a 51.5% improvement in its control rate. However, there was no statistically significant difference between the groups. No serious adverse events occurred during the trial.

Conclusion
The CM-DASH diet combined with 23% low-sodium salt and meal packs demonstrates potentially beneficial effects on glycemic control in patients with hypertension and type 2 diabetes. This intervention reduces salt intake and fosters the development of healthy eating habits, thereby contributing to the improvement of patients' blood glucose. However, larger studies are necessary to confirm these findings.

Trial registration ChiCTR2000029017. Registered January 11, 2020-Prospective registration, http://www.chictr.org.cn/