bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interactions between a saline lagoon and a semi‐confined aquifer on a salinized floodplain of the lower River Murray, southeastern Australia
Authors: Banks E. W. , Simmons C. T. , Jolly I. D. , Doble R. C. , McEwan K. L. , Herczeg A. L. 
Published: September 2009

AbstractThe transport of saline groundwater from local and regional aquifers to the lower River Murray in South Australia is thought to be greatly influenced by the incised lagoons and wetlands that are present in the adjacent floodplain. Interactions between a saline lagoon and semi‐confined aquifer at a floodplain on the River Murray were studied over a 1‐year period using hydrogeological techniques and environmental tracers (Cl−, δ2H and δ18O). Piezometric surface monitoring showed that the lagoon acted as a flow‐through system intercepting local and regional groundwater flow. A chloride mass balance determined that approximately 70% of the lagoon winter volume was lost by evaporation. A stable isotope mass balance estimated leakage from the lagoon to the underlying aquifer. Around 0–38% of the total groundwater inflow into the lagoon was lost to leakage compared to 62–100% of groundwater inflow lost to evaporation. Overall, floodplain wetlands of the type studied here behave as groundwater flow‐through systems. They intercept groundwater discharge, concentrate it and eventually recharge more saline water to the floodplain aquifer. Understanding groundwater–surface water interactions in floodplain wetlands will benefit the effective management of salinity in semi‐arid rivers. Copyright © 2009 John Wiley & Sons, Ltd.
Beyond behavior: eliciting broader change with motivational interviewing
Authors: Wagner Christopher C. , Ingersoll Karen S. 
Published: September 2009

AbstractDescriptions of Motivational interviewing (MI) usually focus on helping clients change a single problematic behavior. In contrast, the current case study shows that MI can serve as a more comprehensive psychotherapy, focused not only on multiple problem behaviors but also on broader change consistent with its roots in client‐centered therapy. In this case, the therapist interwove a focus on several discrete behaviors with a focus on broader lifestyle change as well as increased clarity of client cognitions, values, and choices, resulting in several lasting changes. © 2009 Wiley Periodicals, Inc. J Clin Psychol: In Session 65:1–15, 2009.
Mass spectrometric analysis of the glycosphingolipid‐derived glycans from miniature pig endothelial cells and islets: identification of NeuGc epitope in pig islets
Authors: Kim Yun‐Gon , Harvey David J. , Yang Yung‐Hun , Park Chung‐Gyu , Kim Byung‐Gee 
Published: September 2009

AbstractGlycosphingolipid (GSL) is a major component of the plasma membrane in eukaryotic cells that is involved directly in a variety of immunological events via cell‐to‐cell or cell‐to‐protein interactions. In this study, qualitative and quantitative analyses of GSL‐derived glycans on endothelial cells and islets from a miniature pig were performed and their glycosylation patterns were compared. A total of 60 and 47 sialylated and neutral GSL‐derived glycans from the endothelial cells and islets, respectively, were characterized by matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry (MALDI‐TOF MS) and collision‐induced fragmentation using positive‐ion electrospray ionization (ESI) ion‐trap tandem mass spectrometry (MS/MS). In accordance with previous immunohistochemistry studies, the α‐Gal‐terminated GSL was not detected but NeuGc‐terminated GSLs were newly detected from miniature pig islets. In addition, the neutral GSL‐derived glycans were relatively quantified by derivatization with carboxymethyl trimethylammonium hydrazide (so called Girard's T reagent) and MALDI‐TOF MS. The structural information of the GSL‐derived glycans from pig endothelial cells and islets suggests that special attention should be paid to all types of glycoconjugates expressed on pig tissues or cells for successful clinical xenotransplantation. Copyright © 2009 John Wiley & Sons, Ltd.
Cell decomposition for P‐minimal fields
Authors: Mourgues Marie‐Hélène 
Published: September 2009

AbstractIn [12], P. Scowcroft and L. van den Dries proved a cell decomposition theorem for p‐adically closed fields. We work here with the notion of P‐minimal fields defined by D. Haskell and D. Macpherson in [6]. We prove that a P‐minimal field K admits cell decomposition if and only if K has definable selection. A preprint version in French of this result appeared as a prepublication [8] (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
On (∈, ∈ ∨ q)‐fuzzy filters of R0‐algebras
Authors: Ma Xueling , Zhan Jianming , Jun Young B. 
Published: September 2009

AbstractIn this paper, we introduce the notions of (∈, ∈ ∨ q)‐fuzzy filters and (∈, ∈ ∨ q)‐fuzzy Boolean (implicative) filters in R0‐algebras and investigate some of their related properties. Some characterization theorems of these generalized fuzzy filters are derived. In particular, we prove that a fuzzy set in R0‐algebras is an (∈, ∈ ∨ q)‐fuzzy Boolean filter if and only if it is an (∈, ∈ ∨ q)‐fuzzy implicative filter. Finally, we consider the concepts of implication‐based fuzzy Boolean (implicative) filters of R0‐algebras (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Reproductive toxicity of phthalate esters
Authors: Martino‐Andrade Anderson Joel , Chahoud Ibrahim 
Published: September 2009

AbstractPhthalate esters are ubiquitous environmental contaminants that in general display low‐toxicity. Overall, the reproductive effects of these compounds are well characterized in adult's animals, with gonadal injury observed after high dose exposure. However, results of recent transgeneration studies indicate that the reproductive system of developing animals is particularly vulnerable to certain phthalates. The phenotypic alterations observed in male offspring rats exposed during the perinatal period have remarkable similarities with common human reproductive disorders, including cryptorchidism, hypospadias and low‐sperm counts. Recent results also indicate that high phthalate doses can adversely affect adult and developing female rats. However, the main question involving phthalates is whether the current level of human exposure is sufficient to adversely affect male and/or female reproductive health. Here, we review the reproductive toxicity data of phthalates in adult and developing animals as well as possible modes of action. In addition, we briefly discuss the relevance of animal studies to humans in light of recent epidemiological data and experimental research with low (human relevant) doses. Finally, we point out some critical issues that should be addressed in order to clarify the implications of phthalates for human reproduction.
An analysis of disease severity based on SMN2 copy number in adults with spinal muscular atrophy
Authors: Elsheikh Bakri , Prior Thomas , Zhang Xiaoli , Miller Robert , Kolb Stephen J. , Moore Dan , Bradley Walter , Barohn Richard , Bryan Wilson , Gelinas Deborah , Iannaccone Susan , Leshner Robert , Mendell Jerry R. , Mendoza Michelle , Russman Barry , Smith Stephen , King Wendy , Kissel John T. 
Published: September 2009

AbstractTo evaluate the effect of SMN2 copy number on disease severity in spinal muscular atrophy (SMA), we stratified 45 adult SMA patients based on SMN2 copy number (3 vs. 4 copies). Patients with 3 copies had an earlier age of onset and lower spinal muscular atrophy functional rating scale (SMAFRS) scores and were more likely to be non‐ambulatory. There was, however, no difference between the groups in quantitative muscle strength or pulmonary function testing. Functional scale may be a more discriminating outcome measure for SMA clinical trials. Muscle Nerve, 2009
Aging and the underactive detrusor: A failure of activity or activation?
Authors: Smith Phillip P. 
Published: September 2009

AbstractAimsTo examine the known and potential contributions of motor, sensory, and biomechanical dysfunctions to the clinical problems of detrusor underactivity and detrusor hyperactivity/impaired contractility.MethodsA review of the current literature on non‐obstructive voiding dysfunction associated with aging was conducted. The functional impact of age‐induced biomechanical tissue change via alterations in sensory transduction is considered.ResultsImpaired contractility has been regarded as etiologic of detrusor underactivity. However, an age‐related degradation in detrusor contractility as the primary contributor to impaired bladder emptying has not been conclusively demonstrated. To the extent that detrusor contraction force and duration are dependent upon efferent nerve activity and thus reflex responses to sensory activity, there is a potential impact of impaired sensory function on voiding efficiency. Structural and functional tissue changes accompanying aging may result in altered bladder afferent function, with subsequent reflex impairment of detrusor voiding function.ConclusionsThe relative contributions of motor, sensory, and biomechanical dysfunctions to impaired voiding performance independent of outlet obstruction associated with aging remain to be elucidated. Neurourol. Urodynam. 29:408–412, 2010. © 2009 Wiley‐Liss, Inc.
Sacral neuromodulation in diabetic patients: Success and complications in the treatment of voiding dysfunction
Authors: Daniels David H. , Powell Charles R. , Braasch Matthew R. , Kreder Karl J. 
Published: September 2009

AbstractAimsWe compared success rates, subsequent complications, and possible indications for success of sacral neuromodulation (SNM) for urinary voiding dysfunction in diabetic and non‐diabetic patients.MethodsThirty‐two diabetic patients (mean age 61.8 years, range 27–83) with urge incontinence, urgency–frequency syndrome, and/or urinary retention refractory to non‐surgical treatment were retrospectively evaluated along with 211 non‐diabetic patients (mean age 54.1 years, range 20–86) with similar symptoms. All patients who experienced ≥50% reduction in urinary symptoms following a 7‐ to 21‐day test period went on to permanent SNM device implantation.ResultsNo significant difference was found with respect to successful conversion rates from the test period to permanent implantation between diabetic and non‐diabetic patients. Long‐term success rates at a mean followup of 29.3 months following permanent device implantation for diabetic patients were 69.2% of those with urge incontinence, 85.7% of those with urgency–frequency, and 66.7% of those with urinary retention. The non‐diabetic cohort had success rates of 67.0% for urge incontinence, 67.8% for urgency/frequency, and 58.2% for urinary retention (P = 0.823, 0.157, and 0.631, respectively). No patient experienced intraoperative complications. Nine of 24 (37.5%) devices were explanted postoperatively in diabetic patients compared with 36 of 141 (25.5%) in non‐diabetic patients (P = 0.224). The number of explants due to infection was higher in diabetic patients (16.7%) versus non‐diabetic patients (4.3%; P = 0.018).ConclusionsNo difference in long‐term success rates was seen in diabetic patients when compared with similar, non‐diabetic patients. Diabetic patients did, however, have a higher incidence of device explantation due to infection. Neurourol. Urodynam. © 2009 Wiley‐Liss, Inc.
Zolpidem increases bladder capacity and decreases urine excretion in rats
Authors: Yokoyama Osamu , Matsuta Yosuke , Yanai‐Inamura Hiroko , Watanabe Mai , Ohtake Akiyoshi , Suzuki Masanori , Sasamata Masao 
Published: September 2009

AbstractAimsTo clarify the effects of zolpidem, a γ‐aminobutyric acid (GABA)Areceptor agonist, on bladder function, and urine production, we investigated the effects of zolpidem administration on bladder overactivity induced by cerebral infarction (CI) and on urine excretion increased by water overloading in Wistar rats.MethodsCI was induced by left middle cerebral artery occlusion. The effects on bladder function of zolpidem alone or in combination with the GABAAreceptor antagonist bicuculline, were then examined in the CI rats using cystometry. The antidiuretic effect of zolpidem was investigated in water‐loaded and Brattleboro rats (genetically vasopressin‐deficient). Blood samples were collected from water‐loaded rats to determine the aldosterone level 1 and 6 hr after zolpidem administration.ResultsZolpidem increased bladder capacity dose‐dependently, but had no significant effect on bladder contraction pressure in CI rats. Bicuculline dose‐dependently inhibited zolpidem‐induced increases in bladder capacity without affecting bladder contraction pressure. Zolpidem dose‐dependently decreased the volume of urine excreted in water‐loaded and Brattleboro rats. Compared with the control group, zolpidem significantly increased the aldosterone concentration in the plasma of water‐loaded rats 1 hr after administration.ConclusionsZolpidem increased bladder capacity via a GABAergic mechanism in CI rats, and suppressed urine excretion via a pathway that was not through activation of vasopressin V2receptors in water‐loaded and Brattleboro rats. These results suggest that zolpidem may improve nocturia via an increase in bladder capacity and a decrease in urine excretion. Neurourol. Urodynam. 29:587–591, 2010. © 2009 Wiley‐Liss, Inc.
Bernstein Ritz‐Galerkin method for solving an initial‐boundary value problem that combines Neumann and integral condition for the wave equation
Authors: Yousefi S.A. , Barikbin Z. , Dehghan Mehdi 
Published: September 2009

AbstractIn this article, the Ritz‐Galerkin method in Bernstein polynomial basis is implemented to give an approximate solution of a hyperbolic partial differential equation with an integral condition. We will deal here with a type of nonlocal boundary value problem, that is, the solution of a hyperbolic partial differential equation with a nonlocal boundary specification. The nonlocal conditions arise mainly when the data on the boundary cannot be measured directly. The properties of Bernstein polynomial and Ritz‐Galerkin method are first presented, then Ritz‐Galerkin method is used to reduce the given hyperbolic partial differential equation to the solution of algebraic equations. Illustrative examples are included to demonstrate the validity and applicability of the technique presented in this article. © 2009 Wiley Periodicals, Inc. Numer Methods Partial Differential Eq 2010
Acquired monosomy 7 myelodysplastic syndrome in a child with clinical features suggestive of dyskeratosis congenita and IMAGe association
Authors: McDonald Sharon , Wilson David B. , Pumbo Elena , Kulkarni Shashikant , Mason Philip J. , Else Tobias , Bessler Monica , Ferkol Thomas , Shenoy Shalini 
Published: September 2009

AbstractWe describe a case of acquired monosomy 7 myelodysplastic syndrome (MDS) in a boy with congenital adrenocortical insufficiency, genital anomalies, growth delay, skin hyperpigmentation, and chronic lung disease. Some of his clinical manifestations were suggestive of dyskeratosis congenita (DC), while other features resembled IMAGe association. DC has been linked to mutations in telomere maintenance genes. The genetic basis of IMAGe association is unknown, although mice harboring a mutation in a telomere maintenance gene, Tpp1, have adrenal hypoplasia congenita. We considered the possibility that this patient has a defect in telomere function resulting in features of both DC and IMAGe association. Pediatr Blood Cancer 2010; 54:154–157. © 2009 Wiley‐Liss, Inc.
Critical illness polyneuropathy: A rare but serious adverse event in pediatric oncology
Authors: Charisius Jorma , Stiefel Martina , Merkel Nick , Kornhuber Malte , Haase Roland , Kramm Christof Maria 
Published: September 2009

AbstractCritical illness polyneuropathy (CIP) may aggravate sepsis and multiorgan dysfunction in pediatric oncology patients characterized by quadriparesis and difficult weaning from mechanical ventilation. Here, we report on an adolescent patient with acute lymphoblastic T‐cell leukemia who developed critical illness neuropathy after an episode of sepsis with need for mechanical ventilation and intravenous catecholamines. Differential diagnoses like vincristine‐induced polyneuropathy, anterior lumbosacral radiculopathy (ALR), Guillain–Barré syndrome, and chronic inflammatory demyelinating polyneuropathy — all occurring in pediatric patients with acute leukemia — are discussed. Pediatr Blood Cancer 2010; 54:161–165. © 2009 Wiley‐Liss, Inc.
Thermal, mechanical, and rheological properties of biodegradable polybutylene succinate/carbon nanotubes nanocomposites
Authors: Ali Fathilah Binti , Mohan Raja 
Published: September 2009

AbstractBiodegradable poly(butylene succinate)/carbon nanotubes nanocomposites were prepared by melt mixing process, and the influence of carbon nanotubes on the properties of the nanocomposites was investigated. Differential scanning calorimetry showed that crystallization temperature (Tc) increase with increasing carbon nanotube content. Improvement of tensile modulus was observed by the addition of carbon nanotubes compared with pure poly(butylene succinate). Electrical conductivity showed that conductivity of polybutylene succinate/carbon nanotube composites increased with addition of carbon nanotube content. The storage moduli of polybutylene succinate/carbon nanotube composites are higher than the neat polybutylene succinate. The processability of polybutylene succinate/carbon nanotubes composites was improved and more pronounced in higher content of carbon nanotubes. POLYM. COMPOS., 31:1309–1314, 2010. © 2009 Society of Plastics Engineers
Epoxy/steel fiber composites—A simple model to predict the fiber sedimentation
Authors: Leite J.L. , Rasteiro M.G. , Salmoria G.V. , Ahrens C.H. , Pouzada A.S. 
Published: September 2009

AbstractSedimentation of short steel fibers (SSFs) is an important phenomenon observed in the manufacture by casting of polymer/metal composites. Modeling of the fiber sedimentation has been a subject of research but hardly applied in the context of injection molds. In this study, the sedimentation velocity of the SSF suspension in nonreactive epoxy resin was evaluated theoretically and experimentally. The sedimentation behavior of single and concentrated SSF in epoxy resin was followed experimentally to obtain the terminal and sedimentation velocities. These data were interpreted using theoretical models that take into account the hindered settling factor and the shape factor. The experimental data can be correlated with the theoretical analyses. The findings were used to propose a simple model to predict the sedimentation of steel fibers in viscous resins that are used in composites for making molding blocks. POLYM. COMPOS., 31:1378–1386, 2010. © 2009 Society of Plastics Engineers
Role of transmembrane domain 10 for the function of organic anion transporting polypeptide 1B1
Authors: Gui Chunshan , Hagenbuch Bruno 
Published: September 2009

AbstractThe liver‐specific organic anion transporting polypeptides OATP1B1 and OATP1B3 are highly homologous and share numerous substrates. However, at low concentrations OATP1B1 shows substrate selectivity for estrone‐3‐sulfate. In this study, we investigated the molecular mechanism for this substrate selectivity of OATP1B1 by constructing OATP1B1/1B3 chimeric transporters and by site‐directed mutagenesis. Functional studies of chimeras showed that transmembrane domain 10 is critical for the function of OATP1B1. We further identified four amino acid residues, namely L545, F546, L550, and S554 in TM10, whose simultaneous mutation caused almost complete loss of OATP1B1‐mediated estrone‐3‐sulfate transport. Comparison of the kinetics of estrone‐3‐sulfate transport confirmed a biphasic pattern for OATP1B1, but showed a monophasic pattern for the quadruple mutant L545S/F546L/L550T/S554T. This mutant also showed reduced transport for other OATP1B1 substrates such as bromosulfophthalein and [D‐penicillamine2,5]enkephalin. Helical wheel analysis and molecular modeling suggest that L545 is facing the substrate translocation pathway, whereas F546, L550, and S554 are located inside the protein. These results indicate that L545 might contribute to OATP1B1 function by interacting with substrates, whereas F546, L550, and S554 seem important for protein structure. In conclusion, our results show that TM10 is critical for the function of OATP1B1.
Progress toward heterologous expression of active G‐protein‐coupled receptors in Saccharomyces cerevisiae: Linking cellular stress response with translocation and trafficking
Authors: O'Malley Michelle A. , Mancini J. Dominic , Young Carissa L. , McCusker Emily C. , Raden David , Robinson Anne S. 
Published: September 2009

AbstractHigh‐level expression of mammalian G‐protein‐coupled receptors (GPCRs) is a necessary step toward biophysical characterization and high‐resolution structure determination. Even though many heterologous expression systems have been used to express mammalian GPCRs at high levels, many receptors are improperly trafficked or are inactive in these systems. En route to engineering a robust microbial host for GPCR expression, we have investigated the expression of 12 GPCRs in the yeast Saccharomyces cerevisiae, where all receptors are expressed at the mg/L scale. However, only the human adenosine A2a (hA2aR) receptor is active for ligand‐binding and located primarily at the plasma membrane, whereas other tested GPCRs are mainly retained within the cell. Selective receptors associate with BiP, an ER‐resident chaperone, and activated the unfolded protein response (UPR) pathway, which suggests that a pool of receptors may be folded incorrectly. Leader sequence cleavage of the expressed receptors was complete for the hA2aR, as expected, and partially cleaved for hA2bR, hCCR5R, and hD2LR. Ligand‐binding assays conducted on the adenosine family (hA1R, hA2aR, hA2bR, and hA3R) of receptors show that hA2aR and hA2bR, the only adenosine receptors that demonstrate leader sequence processing, display activity. Taken together, these studies point to translocation as a critical limiting step in the production of active mammalian GPCRs in S. cerevisiae.
No association between variant DNA repair genes and prostate cancer risk among men of African descent
Authors: Lavender Nicole A. , Komolafe Oyeyemi O. , Benford Marnita , Brock Guy , Moore Jason H. , VanCleave Tiva T. , States J. Christopher , Kittles Rick A. , Kidd La Creis R. 
Published: September 2009

AbstractBACKGROUNDRecent reports hypothesize that multiple variant DNA repair gene interactions influence cancer susceptibility. However, studies identifying high‐risk cancer‐related genes use single gene approaches that lack the statistical rigor to model higher order interactions.METHODSTo address this issue, we systematically evaluated individual and joint modifying effects of commonly studied polymorphic base and nucleotide excision repair genes relative to prostate cancer (PCA) risk using conventional logistic regression models and multifactor dimensionality reduction (MDR). We hypothesized that inheriting two or more compromised DNA repair loci may increase PCA risk due to altered gene product function. Six genetic alterations were evaluated using germ‐line DNA samples from 208 PCA cases and 665 disease‐free controls via TaqMan polymerase chain reaction.RESULTSWith the exception ofXPD312, no association existed between individual DNA repair single‐nucleotide polymorphisms (SNPs) and PCA. Individuals with theXPD312 Asn/Asn genotype had an 8.6‐fold increase in risk (OR = 8.59; 95% CI = 1.81–40.66). We did not observe any significant single gene or gene–gene interactions based on MDR modeling.CONCLUSIONSOur findings emphasize the importance of utilizing a combination of traditional and advanced statistical tools to identify and validate single gene and multilocus interactions in relation to cancer susceptibility. Prostate 70: 113–119, 2010. ©2009 Wiley‐Liss, Inc.