bluuebunny/crossref_metadata_2025_split huggingface dataset:
An investigation on adoption of the engineering simulation lab exercise: A case study in Multimedia University, Malaysia
Authors: Balamuralithara B. , Woods P.C. 
Published: January 2010

AbstractSimulation‐based laboratory in engineering education become an important and appealing mode of laboratory replacing highly complex physical laboratory. The attitude of the students towards computers and experience of using the computers are very important factors that may affect the students' adoption of simulation‐based laboratory. In addition to those factors, prior knowledge and preferences on the engineering simulation software are also significant determinants that may influence the adoption of simulation lab exercise among the students. At the same time, different learning styles (cognitive) may affect how a student performs in different lab settings. Many researches have been conducted investigating the elements involved in adoption of computer applications but less work has been done looking into those elements in adoption of simulation lab exercise among engineering students. This research brings new sight in engineering education specifically in simulation‐based laboratory. In this article, we investigate the relationship between students' attitude towards computer, experience in computer usage, students' preferences and prior knowledge on simulation software, students' cognitive style and adoption of the simulation lab exercise among Electronics‐Telecommunications engineering students of Multimedia University, Malaysia. A conceptual model was designed to study the correlations among the variables in the model. The findings from the investigation indicated that all the factors—variables—have positive and significant relationships with the adoption of simulation lab exercise among the respondents in this study expect for the students' attitude towards computer and their preference of using engineering simulation software. Different cognitive styles among the students did not have any effects on their attitude towards computer and adoption to simulation‐based laboratory except for the kinesthetic style on adoption to simulation lab. © 2010 Wiley Periodicals, Inc. Comput Appl Eng Educ 20: 339–345, 2012
Exploring the role of emotion in conflict transformation
Authors: Jameson Jessica Katz , Bodtker Andrea M. , Porch Dennis M. , Jordan William J. 
Published: January 2010

AbstractThis study examines the idea that attention to emotion in conflict management leads to conflict transformation. An experimental design compared mediated and negotiated conflict simulations in which participants were primed to discuss emotions as they moved toward agreement. Participants in the mediation group reported increased positive affect, decreased negative affect, and improved perception of other following the simulation. The negotiation group reported decreased positive affect, increased negative affect, and no difference in perception of other, yet they reported increased satisfaction. Mediated agreements included reference to the ongoing relationship, whereas negotiated agreements included tit‐for‐tat arrangements. Implications for organizational conflict management are discussed.
Validation study of a French version of the modified telephone interview for cognitive status (F‐TICS‐m) in elderly women
Authors: Vercambre Marie‐Noël , Cuvelier Hélène , Gayon Yasemin Atakuman , Hardy‐Léger Isabelle , Berr Claudine , Trivalle Christophe , Boutron‐Ruault Marie‐Christine , Clavel‐Chapelon Françoise 
Published: January 2010

AbstractObjectiveTo evaluate the performance of a French version of the modified Telephone Interview for Cognitive Status (F‐TICS‐m) in identifying cognitive decline among elderly women.MethodsAll women aged 72–86 participating in the ‘Etude Epidémiologique auprès de Femmes de l'Education Nationale’ (E3N) cohort and living in or near Paris constituted the target population of the validation study. Volunteer women (n = 120) underwent both a 20‐min telephone interview and a face‐to‐face neuropsychological examination at an interval of few days (median interval: 10 days). The telephone interview included F‐TICS‐m, as well as a recall of key elements of a short story, arithmetic/verbal problems and two verbal fluency tests. Neuropsychological examination consisted of a standardized battery of cognitive tests (including the Mini‐Mental State Examination (MMSE), the Free and Cued Selective Reminding Test‐FCSRT, Trailmaking tests A and B, the similarities subtest of the Wechsler Adult Intelligence Scale‐III, etc.) the Instrumental Activities of Daily Living questionnaire, and the Geriatric Depression Scale. Neuropsychological examination led to classification of each subject as cognitively normal (n = 92) or impaired/demented (n = 28).ResultsF‐TICS‐m showed satisfactory internal consistency (Cronbach's alpha = 0.69). It correlated linearly with MMSE (Pearson's r = 0.72). Concurrent validity against the gold‐standard classification was satisfactory, with an area under the ROC curve (AUC) of 0.83. The combination of F‐TICS‐m and the other telephone tests had no additional effect on discrimination power in our sample (AUC = 0.81).ConclusionF‐TICS‐m is a valid instrument for assessing the overall cognitive status of French elderly women. Its validity in men and its reproducibility warrant further studies. Copyright © 2010 John Wiley & Sons, Ltd.
The neuropsychological characteristics and regional cerebral blood flow of vascular cognitive impairment‐no dementia
Authors: Cao Xinyi , Guo Qihao , Zhao Qianhua , Jin Lilin , Fu Jianhui , Hong Zhen 
Published: January 2010

AbstractObjectiveTo investigate the neuropsychological characteristics of VCI‐ND and to analyze the relationship between deficit pattern and regional cerebral blood flow (rCBF) in various VCI‐ND subtypes defined by cognitive features.Methods69 subjects diagnosed with VCI‐ND were recruited, then further classified into four subtypes: amnestic VCI‐ND with single memory impairment (subtype I, n = 19), amnestic VCI‐ND with multi‐domain impairment (subtype II, n = 27), non‐amnestic VCI‐ND with single domain impairment (subtype III, n = 16), and non‐amnestic VCI‐ND with multi‐domain impairment (subtype IV, n = 7) according to their cognitive profile. Xenon‐CT scan was administered to 31 VCI‐ND patients (11 of subtype I, 12 of subtype II and 8 of subtype III) and 10 normal controls (NC) to evaluate rCBF.ResultsThe rate of different cognitive domains impairment in VCI‐ND group ranged from 17 to 66%, lowest in clock drawing test and highest in time of modified version of trails making test A and maze tracing compared with NC, significant reduced rCBF was found in bilateral temporal lobe and thalamus, left periventricular white matter and caudate of subtype I, and in left temporal lobe and lenticular nucleus, bilateral periventricular white matter, white matter adjacent to left posterior horn of lateral ventricular and right caudate of subtype III, while significant reduced rCBF of subtype II was found in left subfrontal white matter, bilateral subtemporoparietal white matter, right lenticular nucleus, and in both regions of subtype I and IIIConclusionsThe manifestation of rCBF in VCI‐ND subtypes was consistent with performance of neuropsychological assessment Copyright © 2010 John Wiley & Sons, Ltd.
Cholesterol homeostasis markers are localized to mouse hippocampal pyramidal and granule layers
Authors: Valdez Chris M. , Smith Mark A. , Perry George , Phelix Clyde F. , Santamaria Fidel 
Published: January 2010

AbstractChanges in brain cholesterol homeostasis are associated with multiple diseases, such as Alzheimer's and Huntington's; however, controversy persists as to whether adult neurons produce their own cholesterol, or if it is outsourced to astrocytes. To address this issue, we analyzed 25 genes most immediately involved in cholesterol homeostasis from in situ data provided by the Allen Brain Mouse Atlas. We compared the relative mRNA expression in the pyramidal and granule layers, populated with neurons, with the rest of the hippocampus which is populated with neuronal processes and glia. Comparing the expression of the individual genes to markers for neurons and astrocytes, we found that cholesterol homeostasis genes are preferentially targeted to neuronal layers. Therefore, changes in gene expression levels might affect neuronal populations directly. © 2010 Wiley‐Liss, Inc.
Cardiovascular diseases and hippocampal infarcts
Authors: Rauramaa Tuomas , Pikkarainen Maria , Englund Elisabet , Ince Paul G. , Jellinger Kurt , Paetau Anders , Parkkinen Laura , Alafuzoff Irina 
Published: January 2010

AbstractThe prevalence of hippocampal lesions such as hippocampal infarcts have not been studied in detail even though hippocampal alterations are known to be associated with various clinical conditions such as age‐related degenerative disorders and epilepsy. Methods: Here we defined the hippocampal infarcts and assessed the prevalence of this lesion in large unselected population of 1,245 subjects age ranging from 1 to 99 years (mean age 79 ± 1 S.E.M). Furthermore, we assessed the association of these lesions with various cardio‐ and cerebro‐vascular disorders and other neurodegenerative lesions. The prevalence of hippocampal infarct in the study population of 1,245 subjects was 12%, increasing to 13% when only those with a clinically diagnosed cognitive impairment (n = 311) were analyzed. Large hemispheric brain infarcts were seen in 31% of the study subjects and these lesions were strongly associated with cardiovascular risk factors such as hypertension (43%), coronary disease (32%), myocardial infarct (22%), atrial fibrillation (20%), and heart failure (20%). In contrast, hippocampal infarcts displayed a significant association only with large hemispheric brain infarct, heart failure, and cardiovascular index as assessed postmortem. It is noteworthy that only widespread hippocampal infarcts were associated with clinical symptoms of cognitive impairment or epilepsy. The surprisingly low prevalence of 12% of hippocampal infarcts in aged population found here and the failure to detect an association between this lesion and various cerebro‐ cardio‐vascular lesions is intriguing. Whether susceptibility to ischemia in line with susceptibility to neuronal degeneration in this region is influenced by still undetermined risk‐ factors need further investigation. Furthermore it should be noted that the size of the hippocampal tissue damage, i.e., small vs. large cystic infarcts is of significance regarding clinical alterations. © 2010 Wiley‐Liss, Inc.
Cholinergic activation of hippocampal neural stem cells in aged dentate gyrus
Authors: Itou Yoshie , Nochi Rokuya , Kuribayashi Hiroshi , Saito Yu , Hisatsune Tatsuhiro 
Published: January 2010

AbstractAdult hippocampal neurogenesis contributes to the hippocampal circuit's role in cognitive functioning. New neurons are generated from hippocampal neural stem cells (NSCs) throughout life, but their generation is substantially diminished in aged animals due to a decrease in NSC proliferation. Because acetylcholine (ACh) is an important neurotransmitter released in the hippocampus during learning and exercise that is known to decrease with aging, we investigated whether aged NSCs can respond to ACh. In this study, we found that cholinergic stimulation has a positive effect on NSC proliferation in both young adult (8–12 weeks old) and aged mice (>2 years old). In fresh hippocampal slices, we observed a rapid calcium increase in NSCs in the dentate gyrus after muscarinic cholinergic stimulation, in both age groups. Furthermore, we found that the exercise‐induced promotion of aged NSC proliferation was abrogated by the specific lesioning of the septal cholinergic system. In turn, cholinergic activation by either eserine (physostigmine) or donepezil treatment promoted the proliferation of NSCs in aged mice. These results indicate that NSCs respond to cholinergic stimulation by proliferating in aged animals. Physiological and/or pharmacological cholinergic stimulation(s) may ameliorate cognitive decline in aged animals, by supporting adult hippocampal neurogenesis. © 2010 Wiley‐Liss, Inc.
Regulation of the membrane mucin Muc4 in corneal epithelial cells by proteosomal degradation and TGF‐β
Authors: Lomako Joseph , Lomako Wieslawa M. , Carothers Carraway Coralie A. , Carraway Kermit L. 
Published: January 2010

AbstractMUC4 is a heterodimeric membrane mucin, composed of a mucin subunit ASGP‐1 (MUC4α) and a transmembrane subunit ASGP‐2 (MUC4β), which has been implicated in the protection of epithelial cell surfaces. In the rat stratified corneal epithelium Muc4 is found predominantly in the most superficial cell layers. Since previous studies in other tissues have shown that Muc4 is regulated by TGF‐β via a proteosomal degradation mechanism, we investigated the regulation of corneal Muc4 in stratified cultures of corneal epithelial cells. Application of proteosome or processing inhibitors led to increases in levels of Muc4, particularly in the basal and intermediate levels of the stratified cultures. These changes were accompanied by increases in Muc4 ubiquitination, chaperone association and incorporation into intracellular aggresomes. In contrast, treatment with TGF‐β resulted in reduced levels of Muc4, which were reversed by proteosome inhibition. The results support a model in which Muc4 precursor is synthesized in all layers of the corneal epithelium, but Muc4 is degraded in basal and intermediate layers by a proteosomal mechanism at least partly dependent on TGF‐β inhibition of Muc4 processing. J. Cell. Physiol. 223: 209–214, 2010. © 2009 Wiley‐Liss, Inc.
Extracellular β‐nicotinamide adenine dinucleotide (β‐NAD) promotes the endothelial cell barrier integrity via PKA‐ and EPAC1/Rac1‐dependent actin cytoskeleton rearrangement
Authors: Umapathy Nagavedi S. , Zemskov Evgeny A. , Gonzales Joyce , Gorshkov Boris A. , Sridhar Supriya , Chakraborty Trinad , Lucas Rudolf , Verin Alexander D. 
Published: January 2010

AbstractExtracellular β‐NAD is known to elevate intracellular levels of calcium ions, inositol 1,4,5‐trisphate and cAMP. Recently, β‐NAD was identified as an agonist for P2Y1 and P2Y11 purinergic receptors. Since β‐NAD can be released extracellularly from endothelial cells (EC), we have proposed its involvement in the regulation of EC permeability. Here we show, for the first time, that endothelial integrity can be enhanced in EC endogenously expressing β‐NAD‐activated purinergic receptors upon β‐NAD stimulation. Our data demonstrate that extracellular β‐NAD increases the transendothelial electrical resistance (TER) of human pulmonary artery EC (HPAEC) monolayers in a concentration‐dependent manner indicating endothelial barrier enhancement. Importantly, β‐NAD significantly attenuated thrombin‐induced EC permeability as well as the barrier‐compromising effects of Gram‐negative and Gram‐positive bacterial toxins representing the barrier‐protective function of β‐NAD. Immunofluorescence microscopy reveals more pronounced staining of cell–cell junctional protein VE‐cadherin at the cellular periphery signifying increased tightness of the cell‐cell contacts after β‐NAD stimulation. Interestingly, inhibitory analysis (pharmacological antagonists and receptor sequence specific siRNAs) indicates the participation of both P2Y1 and P2Y11 receptors in β‐NAD‐induced TER increase. β‐NAD‐treatment attenuates the lipopolysaccharide (LPS)‐induced phosphorylation of myosin light chain (MLC) indicating its involvement in barrier protection. Our studies also show the involvement of cAMP‐dependent protein kinase A and EPAC1 pathways as well as small GTPase Rac1 in β‐NAD‐induced EC barrier enhancement. With these results, we conclude that β‐NAD regulates the pulmonary EC barrier integrity via small GTPase Rac1‐ and MLCP‐ dependent signaling pathways. J. Cell. Physiol. 223: 215–223, 2010. © 2010 Wiley‐Liss, Inc.
Cdc20 proteolysis requires p38 MAPK signaling and Cdh1‐independent APC/C ubiquitination during spindle assembly checkpoint activation by cadmium
Authors: Yen Ai‐Hsin , Yang Jia‐Ling 
Published: January 2010

AbstractCdc20, an activator of the anaphase promoting complex/cyclosome (APC/C) ubiquitin ligase, initiates the destruction of key mitotic regulators to facilitate mitosis, while it is negatively regulated by the spindle assembly checkpoint (SAC) to prevent premature anaphase entry. Activation of the p38 mitogen‐activated protein kinase could contribute to mitotic arrest, but the underlying mechanism is unknown. Here we report a novel pathway in which the p38 signaling triggers Cdc20 destruction under SAC elicited by cadmium, a human carcinogen. We found that the cadmium‐induced prometaphase arrest was linked to decreased Cdc20 and accumulated cyclin A protein levels in human cells, whereas the activity of cyclin B1–Cdk1 was unaffected. The Cdc20 half‐life was markedly shortened along with its ubiquitination and degradation via 26S proteasome in cadmium‐treated asynchronous or G2‐enriched cells. Depletion of APC3 markedly suppressed the cadmium‐induced Cdc20 ubiquitination and proteolysis, while depletion of Cdh1, another activator of APC/C, did not. Intriguingly, blockage of p38 activity restored the Cdc20 levels for continuing mitosis under cadmium, while inhibition of JNK activity had no effect. The cadmium‐induced Cdc20 proteolysis was also suppressed during transient depletion of p38α or stable expression a dominant negative form of p38. Inhibition of p38 abolished the induction of Mad2–Cdc20–APC3 complex by cadmium. Moreover, forced expression of MKK6–p38 signaling could promote Cdc20 degradation in a Cdh1‐independent APC/C pathway. In summary, accelerated ubiquitination and proteolysis of Cdc20 is essential for prometaphase arrest that is mediated via the p38 signaling during SAC activation. J. Cell. Physiol. 223: 327–334, 2010. © 2010 Wiley‐Liss, Inc.
Toward an integrated framework for online consumer behavior and decision making process: A review
Authors: Darley William K. , Blankson Charles , Luethge Denise J. 
Published: January 2010

AbstractThis paper presents a comprehensive review of recent empirical studies dealing with online consumer behavior and decision‐making processes. To that end, the paper adapts and extends Engel, Kollat, and Blackwell's (1978) and Engel, Blackwell, and Miniard's (1986) decision‐making model as backdrop in the review of the literature. The vast majority of studies examine the link between external factors and one or more components of the decision‐making process. The findings of this study show a paucity of research on a number of components of decision making, as well as inconsistencies in the way the online environment is characterized. Finally, the findings show that student samples are prevalent among the studies identified and the research method is biased toward the survey method as opposed to experimentation. Discussion and conclusions are provided, and directions for future research are presented. ©2010 Wiley Periodicals, Inc.
The value of losing control: Competition in markets for complements
Authors: Pun Hubert , Heese H. Sebastian 
Published: January 2010

AbstractWhen selling complementary products, manufacturers can often benefit from considering the resulting cross‐market interdependencies. Although using independent retailers makes it difficult to internalize these positive externalities, the ensuing double marginalization can mitigate within‐market competition. We use standard game theoretic analysis to determine optimal distribution channel strategies (through independent retailers or integrated) for competing manufacturers who participate in markets for complements. Our results suggest that a firm's optimal channel choice is highly dependent on its competitive positioning. A firm with a competitive advantage in terms of product characteristics (customer preferences) or production capabilities (cost) might benefit from selling through company‐controlled stores, allowing coordinated pricing across the two markets, whereas a less competitive firm might be better off using independent channel intermediaries to mitigate price competition. We consider two scenarios depending on whether the two firms make their distribution channel decisions sequentially or simultaneously. Although firms are unlikely to make such decisions at exactly the same instant, the simultaneous model also serves as a proxy for the scenario where firms decide sequentially, but where they cannot observe each other's strategic channel choices. For the sequential case, we find that the sequence of entry can have tremendous impact on the two firms'profits; whereas in some cases, the first mover can achieve substantially higher profits, we find that when the two markets are of sufficiently different size and only loosely related, a firm with a competitive advantage might be better off as a follower. Interestingly, our results suggest that, when the markets are of rather similar size, both firms are better off if they enter the industry sequentially. In those cases, the first entrant has incentive to reveal its planned channel strategies, and the follower has incentive to seek out and consider this information. © 2010 Wiley Periodicals, Inc. Naval Research Logistics, 2010
High‐performance aromatic thermosetting resins with hydroxyl and ethynyl groups
Authors: Yang Ming , Shi Song , Wang Mingcun , Luo Zhenhua , Qiu Wenfeng , Wang Yuhui , Feng Zhihai , Zhao Tong 
Published: January 2010

AbstractA novel hydroxyl‐ethynyl‐arene (HEA) resin was synthesized via Aldol condensation and Sonogashira reaction. The structure of the obtained resin was confirmed by the techniques of mass spectroscopy (MS), gel permeation chromatography (GPC), proton nuclear magnetic resonance spectroscopy (1H‐NMR), Fourier transform infrared spectroscopy, (FT‐IR) and elemental analysis (EA). Differential scanning calorimetry (DSC) results showed an exotherm at the temperature range of 187°C–245°C, attributable to crosslinking reaction of the acetylene groups. After thermal cure, the obtained cured resin possessed excellent thermal stability. Thermal gravimetric analysis (TGA) in nitrogen showed the Td5 (temperature of 5% weight loss) was about 400°C, and the char yield in nitrogen was about 78% at 900°C. The laminate composite of HEA resin was prepared and its mechanical and thermal properties were determined. The usefulness of the HEA resin as matrix for ablative composite was evaluated. Copyright © 2010 John Wiley & Sons, Ltd.
ARGET ATRP of acrylonitrile with ionic liquid as reaction media and 1,1,4,7,7‐pentamethyldiethylenetriamine as both ligand and reducing agent in the presence of air
Authors: Chen Hou , Liu Delong , Song Yuting , Qu Rongjun , Wang Chunhua 
Published: January 2010

Abstract[C12mim][BF4], [C8mim][BF4], and [C4mim][BF4] were first applied as reaction media for atom transfer radical polymerization using activators regenerated by electron transfer (ARGET ATRP) of acrylonitrile (AN) with 1,1,4,7,7‐pentamethyldiethylenetriamine (PMDETA) as both ligand and reducing agent in the presence of air. The rate of polymerization in [C12mim][BF4] was considerably faster than in [C8mim][BF4] and [C4mim][BF4]. ARGET ATRP of AN in [C12mim][BF4] were better controlled than in [C8mim][BF4] and [C4mim][BF4] under the same experimental conditions. With an increase in the content of PMDETA, the polymerization provided an accelerated reaction rate and a broader polymer molecular weight distribution. A slow polymerization rate and a broad polydispersity index were observed using TMEDA instead of PMDETA as both ligand and reducing agent. There was an obvious induction period with CuCl2 instead of CuBr2 as catalyst. Well‐defined PAN‐b‐PMMA with higher molecular weight at 104,560 and relatively broader distribution at 1.35 was successfully prepared with PAN as macroinitiator via ARGET ATRP in [C12mim][BF4] in the presence of air. The resultant fibers were obtained with the fineness at 1.17dtex and the tenacity at 6.03cN · dtex−1. Copyright © 2010 John Wiley & Sons, Ltd.