bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Case of Urachal Carcinoma with Meigs's Syndrome
Authors: Kidera Yoshiro , Uchiyama Yoh‐ichi , Iwasaka Tsuyoshi , Ohkuma Yoshinari , Yoshimura Takahiro , Sugimori Hajime 
Published: August 2010

AbstractA case of urachal carcinoma observed in a 41‐year‐old female is reported. Her complaints were easy fatigability, abdominal distention and dyspnea. Ascites, right‐sided pleural effusion and pelvic tumor were observed. Culdo‐centesis and pleural aspiration proved the fluid to be bloody. Because the pelvic tumor was found at laparotomy to arise from the juxta‐vesical region, the tumor was considered to originate in the urachus. Very slow bleeding from the tumor vessels was noted, which accounted for hemoperitoneum and bloody effusion in the right pleural cavity. Resection of the pelvic tumor with a small metastatic nodule on the Douglas' pouch peritoneum, simple total hysterectomy and right salpingo‐oopholectomy were performed. Histopathologic examination of the tumor revealed a poorly differentiated transitional cell carcinoma. Postoperatively the patient was put on a combination chemotherapy of Cisplatin, Adriamycin and cyclophosphamide. She is free from disease at 8 months.
Maternal Mortality Yet to Be Minimized
Authors: Yam A. , Ghosh A. 
Published: August 2010

AbstractThe changes in the causes of maternal deaths in a major referral hospital over a span of 39 years from 1945 to 1983 have been reviewed. There were 235,319 deliveries and 118 maternal deaths. The overall maternal mortality rate per 100,000 total births was 50. The rate declined from 89 during the period 1945 to 1954 to 10 in the last decade. There has been a significant decline in direct maternal deaths from infection, haemorrhage and preeclampsia–eclampsia since the first half of the studied period. Pulmonary embolism and general anaesthesia were not found to be an important cause of maternal death. Heart disease and amniotic fluid embolism were the two major causes of maternal death in the last 19 years. During the past 9 years non‐obstetric causes have almost approached direct causes of maternal death in frequency. Continued vigilance is still needed to eliminate death resulting from haemorrhage, infection and preeclampsia–eclampsia. Risk of maternal death due to other causes can be minimized only if a greater effort is made to identify the at‐risk patients particularly those with medical disorders so that an adequate pre‐conceptional advise and a multi‐disciplinary approach to the patient care can be provided.
Secretion of the β‐subunit of Luteinizing Hormone in Dispersed Rat Anterior Pituitary Cells
Authors: Seki Takashi , Makino Tsunehisa , Tanimoto Satoshi , Izumi Shunichiro , Iizuka Rihachi 
Published: August 2010

AbstractEnzymatically dispersed rat anterior pituitary cells were perifused in order to investigate the secretion pattern of luteinizing hormone (LH) and its β‐subunit (LH‐β) by luteinizing hormone‐releasing hormone (LH‐RH) in vitro.Intermittent stimulations with LH‐RH induced marked release of LH and LH‐β. The self‐priming effect on either LH or LH‐β release by LH‐RH was not significant; in contrast, a desensitization effect produced by this decapeptide hormone was clearly observed in the release of these two peptide hormones. The perifusion technique was revealed to be useful in analyzing the temporal secretion of the gonadotro‐pins from the anterior pituitary cells, and the data suggest that LH‐β is released concomitantly with native LH by LH‐RH in vitro.
Immunocytological Distribution of the Tumor Antigen
Authors: Hoshina Makoto , Kimura Azusa , Shibata Kazuo , Maruo Takeshi , Mochizuki Matsuto 
Published: August 2010

AbstractSerum levels of the cervical cancer associated antigen (TA‐4) have been well correlated with clinical staging of cervical cancer and the response to surgery or radiation therapy. We studied immunohistologically the distribution of TA‐4 in normal and neoplastic cervical tissue. TA‐4 was localized to epithelial tissue of the uterine cervix. During squamous maturation of the cervix, TA‐4 was expressed first in the nucleus and then in the cytoplasm of the original epithelium or the columnar epithelium with squamous metaplasia. Therefore, TA‐4 seems to be associated with squamous maturation or metaplasia. The intensity of TA‐4 staining in neoplastic regions was greater than in normal epithelium. Thus TA‐4 might be related to carcinogenesis of the cervix.
Antenatal Diagnosis and in Utero Treatment of Fetal Arrhythmia
Authors: Hata Toshiyuki , Iida Kohji , Hata Kohkichi , Moriyama Masashi , Kitao Manabu 
Published: August 2010

AbstractAn antenatal diagnosis was made in six fetuses with supraventricular premature beats, and in two with supraventicular and ventricular premature beats, using fetal echocardiography, electrocardiography, and pulsed Doppler ultrasound. Coenzyme Q10 was given to the mother to treat the fetal arrhythmias, in two fetuses. In the first fetus with supraventricular premature beats and severe deceleration, the arrhythmia disappeared during gestation, and in the second fetus with severely irregular supraventricular premature beats and paroxysmal supraventricular tachycardia, the arrhythmia had practically disappeared just before labor. These findings suggest that Coenzyme Q10 warrants further investigation for the treatment of fetal arrhythmia, in utero.
A Scoring System for Toxemia of Pregnancy
Authors: Ichijo Motohiko , Ushioda Etsuo , Oku Masataka , Hiraoka Katsutada , Moriyama Ikuko S. , Nakanishi Akira , Saitoh Shigeru , Iioka Hideaki 
Published: August 2010

AbstractA total of 1026 cases of toxemia of pregnancy were chosen from some 1500 cases collected in cooperation with many hospitals and medical facilities in Japan, and examined for the purpose of devising an appropriate scoring system for toxemia of pregnancy. We prepared various scoring methods relating to toxemia of pregnancy and compared them to determine their value in predicting intrauterine growth retardation, fetal death, and maternal persistent hypertension at 30 days after delivery. A scoring method taking edema, proteinuria, and hypertension (EPH) was found to be better and easier to use than other methods.
Sequential Therapy with Clomiphene Citrate and Human Menopaus‐al Gonadotropin for Induction of Ovulation and Pregnancy
Authors: Yasuda Motoi , Miyake Akira , Aono Toshihiro , Tanizawa Osamu 
Published: August 2010

AbstractClomiphene citrate (clomiphene) and human menopausal gonadotropin (hMG)‐human chorionic gonadotropin (hCG) were given sequentially to 18 patients who failed to ovulate with hMG‐hCG treatment alone. The rates of ovulation with clomiphene‐hMG‐hCG treatment were 94.4% per patient and 76.5% per course. Pregnancy was induced in 14 courses (16.5%) and in 12 patients (66.7%). The incidences of the ovarian hyperstimulation syndrome per patient and per course were 27.8% and 7.1% respectively. The rates of abortion and multiple pregnancy by treatment with clomiphene‐hMG‐hCG were 16.5% and 21.4%, respectively. The present findings suggest that treatment with clomiphene before hMG‐hCG induces ovulation and pregnancy in anovulatory patients who showed no response to hMG‐hCG treatment. Clomiphene‐hMG‐hCG therapy, however, requires careful monitoring of follicle maturation, because the ovarian hyperstimulation syndrome is apt to occur.
Natural Killer Cell Activity in Pregnancy and the Effects of Pregnant Womens' Sera
Authors: Kurashige Takanobu , Morita Hideo , Ogura Hideo , Kurashige Michi , Kitamura Isamu , Kamimura Osamu 
Published: August 2010

AbstractNatural killer cell activity was found to significantly increase until the fifteenth week of gestation, then normalize from the sixteenth week to the end of pregnancy, and slightly increase at one month after delivery.Maternal serum at the ninth week of pregnancy significantly suppressed natural killer cell activity, and sera at twenty and thirty‐six weeks of gestation, and after delivery, moderately suppressed natural killer cell activity, but nonpregnant womens' serum and autologous serum did not suppress natural killer cell activity.
Systemic Lupus Erythematosus in Pregnancy in Hong Kong Chinese
Authors: Yu Andrew , Wong Vivian C. W. , Lee Anthony K. Y. , Hung Beatrice K. M. , Ma H. K. 
Published: August 2010

AbstractIn 37 pregnancies, 28 patients with systemic lupus erythematosus managed in the Department of Obstetrics and Gynaecology of University of Hong Kong in 1973–1982 were reviewed. The abortion rate was much lower than expected. There was no perinatal loss in the series. Renal involvement does not give a worse prognosis, but active disease during pregnancy is associated with a significantly lower birth weight than the inactive disease.
Long‐Term Danazol Treatment for an Adolescent Girl with Aplastic Anemia
Authors: Nakamura Gen‐ichi , Yoshimitsu Kiyotaka , Ootsuka Haruo , Nakano Hitoo , Nagata Yukihiro 
Published: August 2010

AbstractDanazol was administered for four years and ten months to control uterine bleeding in a 12‐year‐old girl who had had aplastic anemia. During treatment, ovulation was suppressed and the amount of uterine bleeding was much less than that of the usual monthly periods. After 58 months of danazol therapy, all the hematological findings became normal. At present, despite restoration of the normal menstrual cycles, she has normal hematological values without blood transfusions. There were few side effects during the ingestion of danazol. Danazol seems to be effective for the long‐term control of uterine bleeding.
Maternal Serum Diamine Oxidase Activity in the Third Trimester
Authors: Legge M. , Hammond E. M. , Ncwsomc B. J. , Duff G. B. , Aickin D. R. 
Published: August 2010

AbstractSerum diamine oxidase activity was determined serially in 192 women in the third trimester of pregnancy. Maternal and fetal complications were absent in 74 of these women but 21 delivered light for dates infants, 18 delivered heavy for dates infants, 58 developed mild hypertension, 14 developed moderate hypertension and seven developed severe hypertension of pregnancy. In addition there were six women whose pregnancies were complicated by diabetes mellitus. Diamine oxidase activity was significantly lower among those pregnancies with light for dates infants and those pregnancies complicated by maternal hypertension. The pregnancies complicated by diabetes mellitus also demonstrated low diamine oxidase activity but the numbers were too few to assess statistically. Pregnancies with heavy for dates infants did not show any significant difference in diamine oxidase activity from normal pregnancies. The low diamine oxidase activity found in some pregnancy complications may indicate a failure of adequate substrate being available to initiate polyamine biosynthesis.
Obstetric Performance of Elderly Primiparae
Authors: Ho Pak‐Chung , So Wai‐Ki , Ma H. K. 
Published: August 2010

AbstractThe obstetric performance of 165 elderly primiparae was compared to that of 443 younger primiparae. The incidence of diabetes mellitus, antepartum haemorrhage, mild hypertension in pregnancy and uterine fibromyoma was increased in the elderly primiparae. The induction rate and caesarean section rate was also increased, but the perinatal mortality rate, though higher than the younger primiparae, was only 18.2/ 1000. The incidence of perinatal morbidity was also low. A history of involuntary sub‐fertility prior to conception did not affect the outcome.
Uterine Activity in Oxytocin Induced Labour
Authors: Arulkumaran S. , Gibb D. M. F. , Ratnam S. S. , Heng S. H. , Lun K. C. 
Published: August 2010

AbstractUterine activity measured by quantifying active contraction area in induced labour showed an initial significant steep increase (incremental phase) followed by a stable phase when the uterine activity was about 1750 k Pas/15 min in nulliparae and multi‐parae with poor cervical score; it was 1500 k Pas/15 min in multiparae with good cervical score. Once this was achieved, further increase in oxytocin dosage did not increase uterine activity but instead revealed a tendency to hypertonic uterine contractions. A marked rise in uterine activity was observed in the late first stage of labour (terminal phase) despite no increase in oxytocin in patients with good cervical scores (>6) at induction but not in those with poor cervical scores (<5). The uterine activity in the stable phase of oxytocin‐induced labour was not significantly influenced by parity and cervical score except multiparae with a cervical score of six or more who had significantly less uterine activity compared to multiparae with poor cervical score or nulliparae.
Ovarian Stimulation for Disordered Ovulatory Cycles
Authors: FRACOG John L. Yovich , Tuvik Ann I , Matson Phillip L. , Willcox David L. 
Published: August 2010

AbstractA total of 391 “ovulatory” women with unexplained infertility had 1,071 treatment cycles (2.74 treatments per patient) with clomiphene citrate (C), human menopausal gonadotrophin (hMG) or a combination of C/hMG; each regimen combined with human chorionic gonadotrophin in the luteal phase. Pre‐treatment monitoring of serum hormones, cervical mucus and ovarian follicle dimensions by ultrasound delineated a relatively narrow range of measurements for “conception” cycles and the term “disordered ovulatory cycles” with follicular or luteal phase defects was applied for those outside the range. At least 70% of treatment cycles responded appropriately and 119 patients conceived (31%) during treatment, showing that “ovulatory” women can benefit by ovarian stimulation. The data also implies that treatment is more likely to be effective for defined ovulatory disorders rather than when given empirically (p>0.05 for clomiphene treatment of follicular phase disorders). However, cervical mucus scores were adversely affected in 22%, of clomiphene treated patients (p> 0.001). This was improved in the C/hMG group and virtually resolved by treatment with hMG alone.
Indication and Outcome of Forceps Deliveries in Lagos: A Study of 553 Cases
Authors: Giwa‐Osagie Osato F. , Ogunyemi Dotun O. , MRCOG Bomi K. Ogedengbe 
Published: August 2010

AbstractOf 14,982 deliveries between 1976–1981 at LUTH, 553 (3.7%) were by forceps of which 88.4% were mid‐forceps and 11.6% were outlet forceps deliveries. The commonest indication was pre‐eclampsia/eclampsia (34.2%) followed by prolonged second‐stage of labour 23.3%,‐ Fetal distress (6.9%,) and prematurity (2.9%,) were uncommon indications. Seventy‐four (13%,) babies had Apgar >5 at 5 minutes. There were 64 perinatal deaths ‐31 fresh stillbirths, 20 macerated stillbirths and 13 neonatal deaths. Sixty‐three of the perinatal deaths were in cases with pre‐existing maternal, obstetrical or fetal complication, the corrected perinatal mortality rate (PNMR) for this was 184.5/1000 while for the uncomplicated elective cases it was 7.7/1000. Pre‐eclampsia/eclampsia was associated with 30 (47.6%) of the perinatal deaths. PNMR was lowest for babies weighing 3.1–4 kg. There were 7 maternal deaths, 6 from eclampsia. There was morbidity in 14.1% cases, the commonest being P.P.H. (9.1%,).
Identification of Immunosuppressive Factors in Normal Pregnant Serum Affecting Antibody Dependent Cell‐Mediated Cytotoxicity
Authors: Yabushita Hiromitsu , Sawaguchi Keizo , Ishihara Minoru , Itoh Yusei 
Published: August 2010

AbstractThe antibody dependent cell‐mediated cytotoxicity (ADCC) activity of peripheral blood lymphocytes was found to be lower in women experiencing normal pregnancy than in nonpregnant females. This decrease was especially striking during the early stage of pregnancy. It was determined that this decrease is caused by two suppressive factors contained in the pregnant serum. One was a high‐molecular‐weight substance with strong suppressive activity, which was not reduced even when the effector cells were washed. This factor showed binding to IgG Fc‐receptors on the lymphocyte surface and to Protein A. Its ability to suppress ADCC activity was eliminated when precipitation was performed with 4% polyethylene glycol. On the basis of these characteristics, it was surmised that this suppressive factor is an IgG‐immune complexlike substance. The suppressive mechanism of this substance is speculated to be competitive binding to the IgG Fc‐receptors of effector cells, which thereby inhibits the binding of specific antibody to these cells. The second suppressive factor was of low molecular weight, and its activity was lost when the effector cells were washed. This factor did not bind to IgG Fc‐receptors, and it is speculated that the action mechanism of this substance must involve direct action against the ADCC reaction system, thereby inhibiting the cellular metabolism of the effector cells.Moreover, it was demonstrated that in normal pregnancy there is a positive correlation between the circulating immune complex concentration in the serum and the serum's suppressive effect on the ADCC activity. This finding suggests that the immune complex‐like substance is the principal factor in the suppression of the ADCC activity.
The Effect of Epidural Analgesia on Labour and Delivery in Chinese Women: A Preliminary Experience
Authors: Lao Terence T. H. , So Arthur P. C. , Cheung Y. T. 
Published: August 2010

AbstractThe preliminary experience with the introduction of epidural analgesia as a routine service on cephalic‐presenting vaginal deliveries in a new hospital is reported. The incidence of instrumental deliveries is significantly increased in this group of women. However, further analysis suggests that women with instrumental delivery following epidural analgesia probably had an abnormal dystocic labour to begin with, in contrast to those who delivered spontaneously.
Cardiac Failure Associated with the Use of Salbutamol for Inhibition of Premature Labour
Authors: Tan Seang Lin , Lui Pao Shun , Marjorie Yvonne 
Published: August 2010

AbstractAn unusual case of congestive cardiac failure precipitated by the use of intravenous salbutamol to inhibit premature labour is reported in a patient with no pre‐existing cardiac disease. The vehicle of administration was 5% dextrose and not normal saline as in most other reports and no dexamethasone was given.
Scanning Electron Microscopy of the Human Endometrium in Pill Users
Authors: Nayel Sayed A. , Gawad AH A. , Sibai Farouk A. , Ghanem Ali A. , Olio Mahmoud M. Abo , Shams Ahmed T. , Hebaish Nadia A. 
Published: August 2010

AbstractTwenty premenstrual endometrial biopsies were examined in 20 fertile women using combined conventional oral contraceptive pills (Anovlar‐1) for periods from 1–15 years using both SEM and light microscopy. Three types of endometria were detected. These were, irregular secretory, suppressed and atrophic endometria. Using scanning electron microscopy the first type showed few ciliated cells with weak cilia as well as collapsed non‐ciliated cells. The second type showed non‐ciliated cells with few signs of secretion. The third type showed rarely ciliated cells, flat secretory cells with no signs of secretions. The longer the duration of pill usage the more were the atrophic changes. Focal glandular proliferation was also detected.
Hyperemesis Gravidarum in Chinese Women
Authors: Chin Robert K. H. , Lao Terence T. H. , Kong Amy M. Y. 
Published: August 2010

AbstractEighty‐two cases of hyperemesis gravidarum managed in a regional hospital in Hong Kong were reviewed. In contrast to the literature, the incidence of hyperemesis gravidarum in the Chinese population fall within the range reported in the European countries. Most of the women were nulliparous, and women who had 2 or more successful pregnancies seldom have this condition.The possible role of human chorionic gonadotrophin in hyperemesis gravidarum is discussed.
Screening for Diabetes in Pregnancy in a Nigerian Population with a High Perinatal Mortality Rate
Authors: Abudu O. O. , Kuti J. A. 
Published: August 2010

AbstractRandom blood glucose values in pregnancy were determined in normal pregnant Nigerian women at different stages of pregnancy. There was no significant difference between the random blood glucose values in the first trimester (mean 3.23±0.64 Mtnol/l; n = 99) or second trimester (mean 3.1 ±0.63 Mmol/l; n=129) or third trimester (mean 3.2±0.79 Mmol/l; n = 143). The mean random blood glucose value of 3.9± 0.79 Mmol/l in 90 non‐pregnant Nigerian women was significantly higher (p<0.001) than the mean values found in the 3 trimesters of pregnancy.Using a one hour blood glucose test after a 50g glucose load we screened for diabetes in pregnancy in 336 Nigerian women. Fifteen (4.5%) had blood glucose values of ≥7.2 Mmol/l. Five of these 15 (33%) women had abnormal oral glucose tolerance test (OGTT); an incidence of about 15 undiagnosed diabetic women per 1,000 antenatal population studied. The perinatal mortality in the study group was 15.5/1000 total birth.
Clinical Significance of CA125 and Its Assessement with an Enzyme Immunoassay
Authors: Shi Qui Ying , Sakawaki Tazu , Kasamatsu Tatsuhiro , Ohkura Hisanao 
Published: August 2010

AbstractAn enzyme immunoassay (EIA) for CA125 has been developed in Japan with a solid‐phase, sandwich, three‐step assay. A high correlation was observed between CA125 levels assayed by EIA and RIA (r = 0.993) in 256 patients. The cut off value was set at 38 U/ml for healthy females. In patients with non‐gynecological, gynecological but non‐ovarian, and ovarian malignant tumors, the positive rates of CA125 were 17%, 16% and 63%, with mean values of S3 U/ml, 183 U/ml and 1042 U/ml, respectively. In patients with non‐gynecological, gynecological but non‐ovarian, and ovarian benign diseases, the positive rates were 0%, 13% and 31% with mean values of 13 U/ml, 21 U/ml and 30 U/ml, respectively. There is a good correlation between stage and level of serum CA125 in ovarian cancer and CA125 levels correlate with the clinical course of ovarian cancer. Thus CA125 EIA is useful in diagnosis and monitoring of malignant ovarian diseases.
An Immunohistochemical, Scanning, and Transmission Electron Microscopical Study of Intervillous Thrombus
Authors: Ikarashi Toshihiko , Takeuchi Shoshichi , Ohnishi Yoshihisa 
Published: August 2010

AbstractTwenty‐one placentae were examined by light microscopic immunohistochemistry, scanning electron microscopy, transmission electron microscopy, and immunoelectron microscopy for the histogenesis of intervillous thrombus formation. Two possible mechanisms were investigated to explain the structural initiation of intervillous thrombus formation. Either the thrombus occurs precisely on the intravillous stromal fibril or the basal lamina, directly facing the intervillous space, and is derived from the degenerated trophoblastic epithelium in a similar fashion to conventional intravascular thrombus formation, or the thrombus is formed on the degenerated trophoblastic epithelium without any trophoblastic epithelial defects. The villous trophoblastic epithelium is, furthermore, thought to behave in the process of thrombus formation as the endothe‐lium in conventional intravascular thrombosis because the villous trophoblastic epithelium had the same stainability as the endothelium in ultrastructural localization of Factor VIII.