bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of oral multispecies probiotic on wound healing, periodontitis and quality of life on patients with diabetes
Authors: Stuermer Ewa Klara , Bang Corinna , Giessler Anna , Smeets Ralf , Janke Toni Maria , Seki Filip David , Debus Eike Sebastian , Franke Andre , Augustin Matthias 
Published: June 2024

Objective: Hard-to-heal (chronic) wounds are common in patients with diabetes and are associated with a decrease in quality of life (QoL). Pathogenic bacteria often colonise hard-to-heal wounds and hinder the healing process which poses a high risk for (systemic) infections. In this study, we aim to prove that probiotics are capable of displacing human pathogenic bacteria, ameliorating inflammation and positively influencing the microenvironment/microbiome of skin and mucosa. Method: In this pilot study, patients with diabetes and hard-to-heal wounds with a duration of 2–120 months received an oral multispecies probiotic daily for six months. Changes in oral, stool and wound microbiome were investigated, and the effects of the probiotic intervention on wound healing, periodontitis and wound-specific quality of life (Wound-QOL-17) were analysed throughout the course of this clinical study. Results: In total, seven of the 20 patients included were unable to complete the study. After six months of oral probiotic intake supplementation in five out of the remaining 13 patients, the wounds had healed completely. Most patients reported an improvement in wound-specific QoL, with particular positive effects on pain and mobility. Microbiome analysis revealed a reduction in Staphylococcus aureus and Pseudomonas aeruginosa, and Staphylococcus epidermis in healed wounds. Conclusion: This findings of this study provide evidence for the beneficial effects of the oral application of a multispecies probiotic over six months in patients with diabetes and hard-to-heal wounds on wound closure, wound microbial pattern, QoL, and on dental health. A randomised, placebo-controlled, double-blinded clinical trial is required to verify the results.
"Long-term effects of center volume on transplant outcomes in adult kidney transplant recipients"
Authors: Azhar Ambreen , Defor Edem , Bandyopadhyay Dipankar , Kamal Layla , Tanriover Bekir , Gupta Gaurav 
Published: June 2024

Background
The influence of center volume on kidney transplant outcomes is a topic of ongoing debate. In this study, we employed competing risk analyses to accurately estimate the marginal probability of graft failure in the presence of competing events, such as mortality from other causes with long-term outcomes. The incorporation of immunosuppression protocols and extended follow-up offers additional insights. Our emphasis on long-term follow-up aligns with biological considerations where competing risks play a significant role.

Methods
We examined data from 219,878 adult kidney-only transplantations across 256 U.S. transplant centers (January 2001-December 2015) sourced from the Organ Procurement and Transplantation Network registry. Centers were classified into quartiles by annual volume: low (Q1 = 28), medium (Q2 = 75), medium-high (Q3 = 121), and high (Q4 = 195). Our study investigated the relationship between center volume and 5-year outcomes, focusing on graft failure and mortality. Sub-population analyses included deceased donors, living donors, diabetic recipients, those with kidney donor profile index >85%, and re-transplants from deceased donors.

Results
Adjusted cause-specific hazard ratios (aCHR) for Five-Year Graft Failure and Patient Death were examined by center volume, with low-volume centers as the reference standard (aCHR: 1.0). In deceased donors, medium-high and high-volume centers showed significantly lower cause-specific hazard ratios for graft failure (medium-high aCHR = 0.892, p<0.001; high aCHR = 0.953, p = 0.149) and patient death (medium-high aCHR = 0.828, p<0.001; high aCHR = 0.898, p = 0.003). Among living donors, no significant differences were found for graft failure, while a trend towards lower cause-specific hazard ratios for patient death was observed in medium-high (aCHR = 0.895, p = 0.107) and high-volume centers (aCHR = 0.88, p = 0.061).

Conclusion
Higher center volume is associated with significantly lower cause-specific hazard ratios for graft failure and patient death in deceased donors, while a trend towards reduced cause-specific hazard ratios for patient death is observed in living donors.
Efficacy and safety of acupuncture for postpartum hypogalactia: A systematic review and meta-analysis of randomized controlled trials
Authors: Bao Qiong-Nan , Yin Zi-Han , Zhou Yuan-Fang , Li Ya-Qin , Zhang Xin-Yue , Xia Man-Ze , Chen Zheng-Hong , Zhong Wan-Qi , Yao Jin , Wu Ke-Xin , Zhang Zhen-Yong , Xu Shao-Jun , Liang Fan-Rong 
Published: June 2024

Background
Postpartum hypogalactia (PH) is prominent during lactation and may negatively impact the mother’s or infant’s health. Acupuncture is widely used to increase maternal breast milk production. However, the effects of acupuncture on PH remain unclear. Therefore, this review aimed to evaluate the efficacy and safety of acupuncture in individuals with PH.

Materials and methods
Articles on potentially eligible randomized controlled trials (RCTs) on acupuncture for PH published from database inception to October 2023 were retrieved from the PubMed, Web of Science, Cochrane Library, EMBASE, EBSCO, Scopus, China National Knowledge Infrastructure, Chinese Biomedical Literature Database, WanFang, and VIP databases. Two reviewers independently screened the records, extracted essential information, and evaluated the methodological quality of the RCTs using the revised Cochrane risk-of-bias (RoB) tool. The primary outcome was a change in serum prolactin (PRL) levels before and after treatment. Secondary outcomes included milk secretion volume (MSV), total effective rate (TER), mammary fullness degree (MFD), and exclusive breastfeeding rate (EBR). Meta-analyses were performed using RevMan v5.4. Finally, the quality of evidence was evaluated using the Grading of Recommendations, Assessment, Development, and Evaluation tool.

Results
This study included 19 RCTs involving 2,400 participants. The included studies were classified as having an unclear to high RoB. Our findings indicated that, overall, acupuncture showed a significant effect in increasing serum PRL levels (standardized mean differences [SMDs] = 1.09, 95% confidence interval [CI]: 0.50, 1.68), MSV (SMD = 1.69, 95% CI: 0.53, 2.86), TER (relative risk [RR] = 1.25, 95% CI: 1.10, 1.42), and EBR (RR = 2.01, 95% CI: 1.07, 3.78) compared to that in the control group; however, no difference in MFD (SMD = 1.17, 95% CI: –0.09, 2.42) was observed. In the subgroup analysis, acupuncture combined with Chinese herbs or conventional treatment was significantly more effective in increasing serum PRL levels, MSV, and TER than did Chinese herbs or conventional treatment alone. Moreover, acupuncture alone resulted in significantly higher serum PRL levels compared to Chinese herbs; however, this benefit was not observed for TER and MFD. The quality of evidence was critically low.

Conclusion
Acupuncture may effectively increase milk secretion in women with PH. However, owing to the low quality of evidence, further rigorously designed studies are warranted to confirm our findings.
Cocaine/crack and cannabis use among transgender women in Goiás, Central Brazil
Authors: Magalhães Larissa Silva , dos Santos Kamila Cardoso , Diniz e Silva Bruno Vinícius , da Silva Filho Gabriel Francisco , da Costa e Silva Grazielle Rosa , Guimarães Rafael Alves , Pillon Sandra Cristina , Caetano Karlla Antonieta Amorim , Martins Regina Maria Bringel , Carneiro Megmar Aparecida dos Santos , Cook Robert L. , Teles Sheila Araujo 
Published: June 2024

Introduction
Illicit drug use is a significant public health problem. Studies have shown a high prevalence of cocaine and cannabis use in transgender women (TGW).

Objective
To describe the consumption patterns of cannabis and cocaine/crack use and variables associated with their use in TGW in Central Brazil.

Methods
A cross-sectional study was conducted on TGW in Goiás, Brazil. Participants were recruited using a respondent-driven sampling method and were interviewed face-to-face about cannabis and crack-cocaine and the variables associated with them. The Alcohol Smoking and Substance Involvement Screening Test was used to assess substance use. Unweighted logistic regression was used to identify variables associated with cannabis and crack cocaine use. P-values < 0.05 were considered statistically significant.

Results
A total of 440 transgender women participated in the study. Their median age was 25 years (interquartile range: 20.5–29.5 years). Most participants were single (85.5%) and had engaged in sex work in their lifetime (58.6%). Cannabis was reported by 68.9% and 53.4% of participants in their lifetime and in the past three months, respectively, and cocaine/crack use was reported by 59.8% and 44.1% of participants in their lifetime and the past three months, respectively. Of the participants, 10.2% reported high-risk cannabis use, and 9.1% reported high-risk cocaine/crack use. Furthermore, 35% of participants reported using both drugs. Previous physical violence (Adjusted Odds Ratio (AOR): 2.37), inconsistent condom uses during anal sex (AOR: 2.17), and moderate-/high-risk cocaine/crack use (AOR: 3.14) were associated with high-risk cannabis use. Previous sexual violence (AOR: 2.84), previous STI (AOR: 2.90), moderate-/high-risk cannabis (AOR: 3.82), and binge drinking (AOR; 3.28) were associated with high-risk cocaine/crack use.

Conclusion
Our study found a high frequency, significant overlap in the use of cannabis and cocaine/crack use and violence associated with these drugs consumption among TGW, highlighting the urgent need for health policies for drug disorders among this socially marginalized group.
Cosmopolitanism and Women’s Fashion in Ghana: History, Artistry and Nationalist Inspiration, Christopher L. Richards (2021)
Authors: Appiah-Nimo Kenneth 
Published: June 2024

Review of: Cosmopolitanism and Women’s Fashion in Ghana: History, Artistry and Nationalist Inspiration, Christopher L. Richards (2021)
Abingdon: Routledge, 266 pp.,
ISBN 978-0-36770-880-1, p/bk, £38.99
ISBN 978-0-36769-420-3, h/bk, £130
Fandom and the Law: A Guide to Fan Fiction, Art, Film & Cosplay, Marc H. Greenberg (2021)
Authors: Koulikov Mikhail 
Published: June 2024

Review of: Fandom and the Law: A Guide to Fan Fiction, Art, Film & Cosplay, Marc H. Greenberg (2021)
Chicago, IL: ABA Book Publishing, 263 pp.,
ISBN 978-1-64105-885-8, p/bk, $59.95
Variasi Spasial Karakteristik Pasang Surut di Laut Jawa Berbasiskan Model Pasut Global TPXO9v5
Authors: Windupranata Wiwin , Nusantara Candida Aulia De Silva , Nuraghnia Alqinthara 
Published: June 2024

Pasang surut (pasut) merupakan fenomena periodik naik turunnya air laut yang berpengaruh besar terhadap seluruh aktifitas manusia di wilayah pesisir dan laut. Tulisan ini menganalisis variasi spasial dari karakteristik pasut yang terjadi di Laut Jawa. Karakteristik pasut tersebut dipetakan dari empat komponen pasut utama (K1, O1, M2 dan S2) dari model pasut global TPXO9v5 dan diverifikasi menggunakan 14 stasiun pasut dari Badan Informasi Geospasial. Hasil verifikasi menunjukkan kesesuaian yang baik antara data model dengan data pengukuran dengan rata-rata nilai RMS 0,8 – 2,2 cm untuk komponen pasut dan 7,6 cm untuk tunggang pasut, sementara tingkat kesesuaian untuk tipe pasut adalah 93%. Nilai amplitudo komponen pasut pada kelompok harian (K1 dan O1) memiliki nilai lebih besar sekitar dua kali lipat dibandingkan dengan kelompok harian ganda (S2 dan M2). Sementara untuk nilai fase, hanya gelombang O1 yang penjalarannya ke arah timur, sementara gelombang lainnya menjalar ke arah barat. Secara spasial, tunggang pasut di Laut Jawa bervariasi dari 0,3 m di bagian tengah pada bujur 108-110° BT dan bertambah tinggi ke arah barat dan timur sampai 1 m. Pengetahuan mengenai variasi spasial karakteristik pasut ini penting dalam mempelajari pola pasut, bidang referensi ketinggian atau kedalaman, atau untuk kerekayasaan seperti manajemen pelabuhan dan instalasi infrastruktur lepas pantai. Tides are a periodic rising and falling sea level phenomenon that significantly impact all human activities in coastal and maritime regions. This paper discusses the spatial variations of tidal characteristics tides in the Java Sea. The characteristics are mapped from four main tidal components (K1, O1, M2, and S2) extracted from the TPXO9v5 tide model and verified by 14 tidal stations. The verifications show a good agreement between the model data and measurements, with an average root mean square (RMS) of 0.8 - 2.2 cm for tidal components and 7.6 cm for tidal range, and the conformity level for tidal types is 93%. The amplitude of the diurnal tidal components (K1 and O1) is approximately twice that of the semi-diurnal tidal components (S2 and M2). Regarding the phase, only the O1 wave propagates eastward, while the other waves propagate westward. Spatially, the tidal range in the Java Sea varies from 0.3 m in the central part at longitudes 108-110° E, increasing in height as it moves westward and eastward to reach 1 m. Information on the spatial variations in tide characteristics is crucial for studying tidal patterns, tidal datum, and engineering purposes like port management and offshore infrastructure.
Wymiar prawny w dyscyplinie geografia społeczno-ekonomiczna i gospodarka przestrzenna. Podstawy teoretyczne i zagadnienia badawcze
Authors: Czasopisma Redakcja 
Published: June 2024

Celem artykułu jest określenie płaszczyzn problemowo-przedmiotowych dotyczących ujmowania perspektywy prawnej w dyscyplinie geografia społeczno-ekonomiczna i gospodarka przestrzenna. Dla potrzeb realizacji tego celu najpierw wskazano ogólne relacje występujące między naukami geograficznymi i prawnymi. Następnie wyodrębniono i przedstawiono kluczowe nurty teoretyczne, które ułatwiają doprecyzowanie roli wymiaru prawnego w geografii społeczno-ekonomicznej i gospodarce przestrzennej, akcentując i charakteryzując przede wszystkim podejście instytucjonalne i geografię prawną. Następnie wyodrębniono najbardziej istotne tematy, w których występuje związek między wymiarem prawnym a geografią społeczno-ekonomiczną i gospodarką przestrzenną.
Die Entstehung des deutschen

werden+Infinitiv-Futurs – ein alternatives Szenario
Authors: Jäger Agnes 
Published: June 2024

Abstract
In this paper, an alternative scenario of the development of German werden future is suggested based on a reanalysis of originally predicative past participles in werden-copula constructions as infinitives. The morpho-phonological and argument-structural preconditions for this reanalysis restrict the types of verbs expected in the relevant bridging contexts to certain strong and unaccusative verbs, which is supported by the results of a comprehensive corpus analysis of werden constructions in Old High German and Old Low German. At the same time, this scenario may explain the diachronic and areal distribution of werden future by virtue of the crucial role it assigns to the ge- prefix.
An Empirical Examination of Aging’s Ramifications on Large-scale Agriculture: China’s Perspective
Authors: Ji Mingbo , Ying Jiang , Shao Xuyang , Tian Yihao 
Published: June 2024

Abstract
Population aging has become a significant issue faced by major global economies. The rapid urbanisation process in China has led to a higher rate of aging in rural areas compared to urban areas. Existing studies have predominantly focused on the impact of aging on agricultural economics and production, with limited exploration into its effects on large-scale agriculture. Given the importance of large-scale agriculture as a crucial initiative for expanding agricultural investment and increasing land capital accumulation, it is pertinent to further investigate the implications of aging in this sector. The empirical examination of the impact of population aging on large-scale agriculture holds significant relevance for developing countries globally. These nations face dual challenges: an aging population and the need for agricultural modernisation. Research can aid in formulating targeted policies to address labour shortages, agricultural technological innovation, and market dynamics, thereby promoting sustainable development and food security. This study utilises data from China’s Third National Agricultural Census and employs measurements of aging at both the rural household and county-city dimensions. The analysis includes an examination of the moderating effects of per capita arable land area and the level of mechanisation on the impact of aging on large-scale agriculture. The findings of the study are as follows: (1) From the perspective of rural households, aging leads to an increase in the age of the rural labour force, resulting in a significant decrease in the probability of rural households participating in large-scale agriculture. (2) At the county-city level, aging contributes to a decline in the proportion of the population participating in large-scale agriculture, which is detrimental to the development of this sector. (3) In certain circumstances, the negative impact of aging on large-scale agriculture is exacerbated in areas with higher levels of agricultural mechanisation.
„Goethe und Einer seiner Bewunderer“: Arno Schmidt und die Probleme literarischer Öffentlichkeit nach 1945
Authors: Schauer Hendrikje J. 
Published: June 2024

Abstract
The article takes a starting point from two contrasting views in literary research on Arno Schmidt’s relation to the public sphere: Schmidt is, on the one hand, depicted as a solitary writer withdrawn from the public; he is, on the other hand, portrayed as a public provocateur and literary strategist. The article turns to his prose and examines how the problems of the public sphere are reflected in one of Arno Schmidt’s narratives: In 'Goethe und Einer seiner Bewunderer', the article argues, the limits and possibilities of writing after 1945 are tested.
Swer meret die gewizen min: höfische Frauenbildung im Wechsel MF 35,16
Authors: Sager Alexander 
Published: June 2024

Abstract
This essay explores courtly education for women as the context for early Minnesang and considers evidence from German courtly romance as well as from the Latin tradition. In this light it proposes a new reading of the female stanzas in the Wechsel MF 35,16, ascribed to Dietmar von Aist.
Scherzrede und Kampf: Vollzugsformen von hövescheit und mann-männlichen Bindungsformen in Partonopier und Meliûr
Authors: Egidi Margeth 
Published: June 2024

Abstract
The article examines male-coded jest and mockery speeches as well as stagings of chivalric combat in Konrad von Würzburg’s Partonopier und Meliûr as complementary performances of hövescheit, dealing with the ambivalence and dynamics of male-to-male bonding between equality, agonality and hierarchy, rivalry and friendship. In this context, the functionally subordinate difference of faith becomes a test case for the validity of hövescheit.
Signed, sealed, delivered – digital approaches to Byzantine sigillography
Authors: Neuefeind Claes , Bigalke Jan , Catalano Maria Teresa , Drach Sviatoslav , Efthymoglou Sofia , Evening Pia , Filosa Martina , Malatras Christos , Schaeben Marcel , Sode Claudia 
Published: June 2024

Abstract
In this paper we present a number of digital approaches in the field of Byzantine sigillography conducted in two projects currently running at the University of Cologne. We describe how technologies and methodologies from the Digital Humanities can help overcome some of the limitations in Byzantine sigillography that result from and contribute to its status as a ‘rare subject’. Building on a long tradition and leveraging methods and techniques from the Digital Humanities, this paper describes some important steps already taken towards a digital renewal of the discipline. We are well aware that it takes much more than a locally organised group of scholars to establish any discipline anew, and so this paper aims to be a stimulus to future work.
Digital Divide and University Students’ Online Learning amidst Covid-19 Pandemic in Malaysia
Authors: Subramaniam Latha , Yap Ching Seng , Jalaludin Farah Waheeda , Hen Kai Wah 
Published: June 2024

Abstract
The advent of digitalization has been hailed as a remedy to mitigate the impact of the Covid-19 pandemic. However, it has also brought to light the existence of a digital divide, exacerbating the hardships faced by those who are digitally excluded. Amidst the turmoil of the crisis, there has been limited attention given to addressing the digital divide in developing countries including Malaysia. In response, Malaysian universities swiftly transitioned to online learning to curb the spread of the contagion. Nonetheless, this rapid shift has inadvertently marginalized underprivileged students, hindering their access to the benefits of online education. Employing the three-level digital divide framework, this study aims to probe into the extent of the digital divide among Malaysian university students and evaluate its progression. Through mean score and frequency analyses, we assessed the magnitude of the digital divide among these students. Furthermore, we employed partial least squares structural equation modeling to gauge the flow of the digital divide from the initial level to the third level. Subsequently, we examined the mediating roles of material access, digital skills, and digital usage. The findings revealed that the digital divide persists across all three levels among university students in Malaysia. The path analysis lends support to all proposed hypotheses, with the exception of digital usage as a predictor of student satisfaction and as a mediator.
The role of epigenetics in rare diseases
Authors: Horsthemke Bernhard 
Published: June 2024

Abstract
Epigenetic control systems are based on chromatin modifications (DNA methylation, histone modifications and nucleosome positioning), which affect the local kinetics of gene expression. They play an important role in maintaining cell fate decisions, X inactivation and genomic imprinting. Aberrant chromatin states that are associated with a deleterious change in gene expression are called epimutations. An epimutation can be a primary epimutation that has occurred in the absence of any genetic change or a secondary epimutation that results from a mutation of a cis-acting regulatory element or trans-acting factor. Epimutations may play a causative role in disease, for example in imprinting disorders, or may be part of the pathogenetic mechanism as in the fragile X syndrome and in syndromes caused by a mutation affecting a chromatin modifier. For several diseases, DNA methylation testing is an important tool in the diagnostic work-up of patients.