bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mortality in men with localized prostate cancer treated with brachytherapy with or without neoadjuvant hormone therapy
Authors: Dosoretz Amy M. , Chen Ming‐Hui , Salenius Sharon A. , Ross Rudolf H. , Dosoretz Daniel E. , Katin Michael J. , Mantz Constantine , Nakfoor Bruce M. , D'Amico Anthony V. 
Published: January 2010

AbstractBACKGROUND:Discrepancies exist regarding the impact of neoadjuvant hormone therapy (NHT) on the risk of all‐cause mortality (ACM) in men who receive brachytherapy for localized prostate cancer. Therefore, the objective of the current study was to examine the effect of NHT on the risk of ACM in men with prostate cancer who receive with brachytherapy.METHODS:The study cohort included 2474 men with localized prostate cancer who either received NHT (N = 1083) or did not receive NHT (N = 1391) and brachytherapy without supplemental external beam radiation between 1991 and 2005 at centers within the 21st Century Oncology Consortium. All men had at least 2 years of follow‐up. Low‐risk, intermediate‐risk, and high‐risk disease was present in 65%, 23%, and 12% of men, respectively. A Cox regression multivariate analysis was used to evaluate the risk of ACM in men who received NHT compared with all others adjusting for age, prostate‐specific antigen level, Gleason score, and tumor classification.RESULTS:After a median follow‐up of 4.8 years (interquartile range, 3.3‐7.5 years) and adjusting for known prostate cancer prognostic factors and age, treatment with NHT was associated significantly with an increased risk of ACM (adjusted hazard ratio, 1.24; 95% confidence interval, 1.01‐1.53; P = .04) in men aged ≥73 years. In men who were younger than the median age of 73 years, hormone therapy use was not significant (P = .34).CONCLUSIONS:Compared with men who were younger than the median age of 73 years, men aged ≥73 years with localized prostate cancer who received brachytherapy and NHT had an increased risk of ACM compared with men who did not receive NHT. Cancer 2010. © 2010 American Cancer Society.
Perils of quinolone exposure in cancer patients
Authors: Rangaraj Gopi , Granwehr Bruno P. , Jiang Ying , Hachem Ray , Raad Issam 
Published: January 2010

AbstractBACKGROUND:The objective of this study was to determine the effect of antibiotic use (including prophylaxis) on the emergence of multidrug‐resistant (MDR) breakthrough bacteremia in cancer patients.METHODS:In this retrospective study, the authors identified all bacteremia episodes from July 2005 to December 2006 at their tertiary cancer center and compared the bacteria types and antimicrobial resistance in isolates from patients who had received antimicrobial agents as therapy or prophylaxis (breakthrough infections) with those from patients who had not received antimicrobial agents (nonbreakthrough bacteremia).RESULTS:Breakthrough bacteremia was more likely to be associated with MDR Escherichia coli (P = .002), MDR Pseudomonas aeruginosa (P = .02), and vancomycin‐resistant enterococci (P = .01). Multivariate analysis revealed that breakthrough bacteremia was associated with hematologic malignancies and neutropenia (odds ratios, 9.9 and 3.0, respectively). Fluoroquinolone use was associated significantly with the emergence of methicillin‐resistant Staphylococcus aureus (P = .04), MDR E. coli (P < .001), and MDR P. aeruginosa (P = .05). A strong association was observed between fluoroquinolone use and breakthrough bacteremia in multivariate analysis (odds ratio, 22; P < .001). Patients who had received vancomycin were more likely to have vancomycin‐resistant enterococci bloodstream isolates than patients who had not received antibacterial agents (P < .001).CONCLUSIONS:Breakthrough infections were more common in neutropenic patients and in patients who had hematologic malignancies. The isolation of MDR organisms was associated strongly with the use of fluoroquinolones. The current findings demonstrated the importance of using a comprehensive approach to the prevention of MDR bacterial infections, including the initiation of antibiotic stewardship programs. Cancer 2010. © 2010 American Cancer Society.
Early 18F‐2‐fluoro‐2‐deoxy‐d‐glucose positron emission tomography may identify a subset of patients with estrogen receptor‐positive breast cancer who will not respond optimally to preoperative chemotherapy
Authors: Martoni Andrea A. , Zamagni Claudio , Quercia Sara , Rosati Marta , Cacciari Nicoletta , Bernardi Alessandra , Musto Alessandra , Fanti Stefano , Santini Donatella , Taffurelli Mario 
Published: January 2010

AbstractBACKGROUND:A pathologic complete response (pCR) and minimal residual disease (pMRD) after preoperative chemotherapy (PCT) for early stage or locally advanced breast cancer (BC) correlates with a good prognosis.METHODS:Patients who received from 6 to 8 cycles of PCT for BC were monitored by 18F‐2‐fluoro‐2‐deoxy‐D‐glucose positron emission tomography (18F‐FDG‐PET), and the maximal standardized uptake value (SUVmax) was calculated at baseline, after 2 cycles, after 4 cycles, and at the end of PCT. SUVmax percentage changes (Δ‐SUV) were compared with the pathologic response rate. Patients who had a pCR or pMRD in the tumor and an absence of cancer cells in ipsilateral axillary lymph nodes were defined as having obtained an optimal pathologic response (pR), whereas all the other conditions were classified as a pathologic nonresponse (pNR).RESULTS:Of 34 patients, 7 (21%) achieved a pR (3 patients had a pCR, and 4 patients had pMRD). After the second cycle, the Δ‐SUV threshold with optimal negative predictive value to predict a pR was 50%. Twenty‐six patients (76%) had a Δ‐SUV >50%, including all 7 patients who had a pR and 19 patients who had a pNR. Conversely, all 8 patients who had a Δ‐SUV ≤50% had a pNR. All 8 of those patients had estrogen recepetor‐positive tumors.CONCLUSIONS:Early evaluation of metabolic response by 18F‐FDG‐PET during PCT was able to identify 30% of patients, all with estrogen receptor‐positive tumors, who would not obtain pR after completion of chemotherapy program. Cancer 2010. © 2010 American Cancer Society.
Ultra‐early predictive assay for treatment failure using functional magnetic resonance imaging and clinical prognostic parameters in cervical cancer
Authors: Mayr Nina A. , Yuh William T. C. , Jajoura David , Wang Jian Z. , Lo Simon S. , Montebello Joseph F. , Porter Kyle , Zhang Dongqing , McMeekin D. Scott , Buatti John M. 
Published: January 2010

AbstractBACKGROUND:The authors prospectively evaluated magnetic resonance imaging (MRI) parameters quantifying heterogeneous perfusion pattern and residual tumor volume early during treatment in cervical cancer, and compared their predictive power for primary tumor recurrence and cancer death with the standard clinical prognostic factors. A novel approach of augmenting the predictive power of clinical prognostic factors with MRI parameters was assessed.METHODS:Sixty‐two cervical cancer patients underwent dynamic contrast‐enhanced (DCE) MRI before and during early radiation/chemotherapy (2‐2.5 weeks into treatment). Heterogeneous tumor perfusion was analyzed by signal intensity (SI) of each tumor voxel. Poorly perfused tumor regions were quantified as lower 10th percentile of SI (SI[10%]). DCE‐MRI and 3‐dimensional (3D) tumor volumetry MRI parameters were assessed as predictors of recurrence and cancer death (median follow‐up, 4.1 years). Their discriminating capacity was compared with clinical prognostic factors (stage, lymph node status, histology) using sensitivity/specificity and Cox regression analysis.RESULTS:SI(10%) and 3D volume 2‐2.5 weeks into therapy independently predicted disease recurrence (hazard ratio [HR], 2.6; 95% confidence interval [95% CI], 1.0‐6.5 [P = .04] and HR, 1.9; 95% CI, 1.1‐3.5 [P = .03], respectively) and death (HR, 1.9; 95% CI, 1.0‐3.5 [P = .03] and HR, 1.9; 95% CI, 1.2‐2.9 [P = .01], respectively), and were superior to clinical prognostic factors. The addition of MRI parameters to clinical prognostic factors increased sensitivity and specificity of clinical prognostic factors from 71% and 51%, respectively, to 100% and 71%, respectively, for predicting recurrence, and from 79% and 54%, respectively, to 93% and 60%, respectively, for predicting death.CONCLUSIONS:MRI parameters reflecting heterogeneous tumor perfusion and subtle tumor volume change early during radiation/chemotherapy are independent and better predictors of tumor recurrence and death than clinical prognostic factors. The combination of clinical prognostic factors and MRI parameters further improves early prediction of treatment failure and may enable a window of opportunity to alter treatment strategy. Cancer 2010. © 2010 American Cancer Society.
The effects of paclitaxel, dose density, and trastuzumab on treatment‐related amenorrhea in premenopausal women with breast cancer
Authors: Abusief Mary E. , Missmer Stacey A. , Ginsburg Elizabeth S. , Weeks Jane C. , Partridge Ann H. 
Published: January 2010

AbstractBACKGROUND:Little information is available regarding the effects of new adjuvant treatment regimens on menstrual functioning in premenopausal women with early breast cancer.METHODS:The authors conducted a retrospective review of data from premenopausal women who received treatment for early breast cancer to evaluate the rates of amenorrhea in follow‐up. The women who were included received treatment with either doxorubicin and cyclophosphamide (AC) or combined AC and paclitaxel (T) (AC‐T) given either every 3 weeks, or as a dose‐dense (DD) regimen, or as AC followed by weekly T with trastuzumab or followed by trastuzumab (AC‐T+trastuzumab). A multivariate logistic regression analysis was conducted to evaluate amenorrhea during follow‐up.RESULTS:Of 431 patients who were eligible for analysis, the average age at diagnosis was 13 years (range, 25‐55 years), 61% of women received AC only, and 39% received AC‐T. Of the 39% who received AC‐T, 49% of women received DD therapy, 14% received AC‐T+trastuzumab, and 71% of all patients received tamoxifen (TAM). The median follow‐up was 33 months (range, 6‐114 months). After adjusting for age, weight, gravidity, parity, age at menarche, smoking, alcohol use, TAM use, type and regimen of chemotherapy, and use of trastuzumab, the likelihood of remaining amenorrheic was not statistically different in patients who received AC‐T versus AC (odds ratio [OR], 1.59; 95% confidence interval [CI], 0.8‐3.2), DD treatment versus treatment every 3 weeks (OR, 0.56; 95% CI, 0.25‐1.3), or AC‐T + trastuzumab (OR, 0.6; 95% CI, 0.22‐1.61). Amenorrhea was associated significantly with TAM use and age at diagnosis.CONCLUSIONS:Recent advances in the adjuvant treatment of early breast cancer do not appear to have increased the risk of amenorrhea in premenopausal women. Cancer 2010. © 2010 American Cancer Society.
Should extrapulmonary small cell cancer be managed like small cell lung cancer?
Authors: Brennan Sinead M. , Gregory Deborah L. , Stillie Alison , Herschtal Alan , Mac Manus Michael , Ball David L. 
Published: January 2010

AbstractBACKGROUND:The aim of this study was to determine if extrapulmonary small cell carcinomas (EPSCC) should be managed using protocols similar to those for small cell lung cancer (SCLC).METHODS:Treatment strategies, survival, patterns of failure, and prognostic factors for patients with EPSCC were analyzed retrospectively at a large cancer center. SCLC was excluded by thoracic computed tomography (75%) or chest radiography (25%).RESULTS:Of 120 eligible patients, 70% had limited disease (LD). Treatment modalities included chemotherapy (n = 82; 68%), radiotherapy (RT) (n = 80; 67%), and surgery (n = 41, 34%). The median survival for patients with LD and extensive disease was 1.4 years and 0.7 years, respectively. Gynecologic (n = 31) and gastrointestinal (n = 28) were the most common primary tumor sites. Gynecologic and head and neck primary tumor sites had better 1‐year survival than other sites (P = .019 and 0.005, respectively). Brain metastasis was the site of first distant failure in 4.1% of patients versus 35% for soft tissue metastases. The lifetime risk of brain metastasis was 13%. Definitive RT (P = .004), LD (P = .028), and prophylactic cranial irradiation (PCI) (P = .022) were found to be positive prognostic factors and weight loss (P < .001) was a negative prognostic factor on multivariate analysis.CONCLUSIONS:Patients with EPSCC usually experienced short survival, often with early distant metastasis. Although PCI was associated with improved overall survival, brain metastasis was less frequent than in patients with SCLC, and therefore the potential benefit of PCI was less than in patients with SCLC. Definitive chemoradiotherapy was associated with better outcomes and should be delivered whenever feasible. Cancer 2010. © 2010 American Cancer Society.
Direct Arylation of Imidazo[1,2‐b]pyridazines: Microwave‐Assisted One‐Pot Suzuki Coupling/Pd‐Catalysed Arylation
Authors: El Akkaoui Ahmed , Berteina‐Raboin Sabine , Mouaddib Abderrahim , Guillaumet Gérald 
Published: January 2010

AbstractDirect intermolecular C–H arylation of 6‐chloroimidazo[1,2‐b]pyridazine in its 3‐position was achieved, and the tolerance to reaction conditions in the presence of chloro groups was investigated. Various 3‐(hetero)arylimidazo[1,2‐b]pyridazines were synthesized in good to excellent yields. This methodology was successfully applied to the synthesis of 3,6‐di‐ and 2,3,6‐trisubstituted imidazo[1,2‐b]pyridazines by a microwave‐assisted, one‐pot, two‐step Suzuki cross‐coupling/palladium‐catalysed arylation process.
Down‐regulation of Notch‐1 and Jagged‐1 inhibits prostate cancer cell growth, migration and invasion, and induces apoptosis via inactivation of Akt, mTOR, and NF‐κB signaling pathways
Authors: Wang Zhiwei , Li Yiwei , Banerjee Sanjeev , Kong Dejuan , Ahmad Aamir , Nogueira Veronique , Hay Nissim , Sarkar Fazlul H 
Published: January 2010

AbstractNotch signaling is involved in a variety of cellular processes, such as cell fate specification, differentiation, proliferation, and survival. Notch‐1 over‐expression has been reported in prostate cancer metastases. Likewise, Notch ligand Jagged‐1 was found to be over‐expressed in metastatic prostate cancer compared to localized prostate cancer or benign prostatic tissues, suggesting the biological significance of Notch signaling in prostate cancer progression. However, the mechanistic role of Notch signaling and the consequence of its down‐regulation in prostate cancer have not been fully elucidated. Using multiple cellular and molecular approaches such as MTT assay, apoptosis assay, gene transfection, real‐time RT‐PCR, Western blotting, migration, invasion assay and ELISA, we found that down‐regulation of Notch‐1 or Jagged‐1 was mechanistically associated with inhibition of cell growth, migration, invasion and induction of apoptosis in prostate cancer cells, which was mediated via inactivation of Akt, mTOR, and NF‐κB signaling. Consistent with these results, we found that the down‐regulation of Notch‐1 or Jagged‐1 led to decreased expression and the activity of NF‐κB downstream genes such as MMP‐9, VEGF, and uPA, contributing to the inhibition of cell migration and invasion. Taken together, we conclude that the down‐regulation of Notch‐1 or Jagged‐1 mediated inhibition of cell growth, migration and invasion, and the induction of apoptosis was in part due to inactivation of Akt, mTOR, and NF‐κB signaling pathways. Our results further suggest that inactivation of Notch signaling pathways by innovative strategies could be a potential targeted approach for the treatment of metastatic prostate cancer. J. Cell. Biochem. 109: 726–736, 2010. © 2010 Wiley‐Liss, Inc.
Differentiation of human umbilical cord Wharton's jelly‐derived mesenchymal stem cells into germ‐like cells in vitro
Authors: Huang Peng , Lin Li Min , Wu Xiao Ying , Tang Qiu Ling , Feng Xue Yong , Lin Guang Yu , Lin Xiaobo , Wang Hong Wu , Huang Tian Hua , Ma Lian 
Published: January 2010

AbstractRecent studies have demonstrated that mesenchymal stem cells could differentiate into germ cells under appropriate conditions. We sought to determine whether human umbilical cord Wharton's jelly‐derived mesenchymal stem cells (HUMSCs) could form germ cells in vitro. HUMSCs were induced to differentiate into germ cells in all‐trans retinoic acid, testosterone and testicular‐cell‐conditioned medium prepared from newborn male mouse testes. HUMSCs formed “tadpole‐like” cells after induction with different reagents and showed both mRNA and protein expression of germ‐cell‐specific markers Oct4 (POUF5), Ckit, CD49f (α6), Stella (DDPA3), and Vasa (DDX4). Our results may provide a new route for reproductive therapy involving HUMSCs and a novel in vitro model to investigate the molecular mechanisms that regulate the development of the mammalian germ lineage. J. Cell. Biochem. 109: 747–754, 2010. © 2010 Wiley‐Liss, Inc.
Acid catalyzed halogen dance on deactivated pyrroles
Authors: Tutino Federico , Papeo Gianluca , Quartieri Francesca 
Published: January 2010

Abstract
magnified imageA study on the acid catalyzed halogen dance (ACHD) on deactivated bromopyrroles is reported. A different behavior is observed when considering singly deactivated pyrrole alkylcarboxamides, or doubly deactivated pyrroleketo‐lactams (aldisines). Although less electron deficient pyrrole alkylcarboxamides suffer from ACHD, the double deactivation on keto‐lactams disfavors pyrrole ring protonation thus preventing halogen scrambling. The mechanism involved in the rearrangement is hypothesized. J. Heterocyclic Chem., 2010.
An efficient synthesis of pyrido[2,3‐d]pyrimidine derivatives in ionic liquid
Authors: Shi Da‐Qing , Zhou Yao , Liu Hai 
Published: January 2010

Abstract
magnified imageA series of 5,7‐diarylpyrido[2,3‐d]pyrimidine‐2,4(1H,3H)‐diones was synthesized via the reaction of 6‐aminopyrimidine‐2,4‐dione and α,β‐unsaturated ketones in ionic liquid without using any catalyst. This protocol has the advantages of easier work‐up, milder reaction conditions, high yields, and environmentally benign procedure over traditional methods. J. Heterocyclic Chem., 2010.
Preparation of NH‐pyrazoleacetic acid anilides from trilithiated acetoacetanilide, select aromatic esters, and hydrazine
Authors: Smith Ellyn A. , Potter Chandra , Kennedy Zachary C. , Puciaty Andrew J. , Acevedo‐Jake Amanda M. , Hersey Stephen D. , Metz Clyde R. , Pennington William T. , VanDerveer Donald G. , Beam Charles F. 
Published: January 2010

Abstract
magnified imageAcetoacetanilide was trilithiated with excess lithium diisopropylamide to form a reactive trianion‐type intermediate. This was followed by a regioselective Claisen‐type condensation of the trilithiated intermediate with a variety of aromatic esters to afford new C‐acylated intermediates, 3,5‐diketopentane‐carboxanilides, that were not isolated but immediately condensed‐cyclized with hydrazine to afford the NH‐pyrazoleacetanilides, 5‐aryl‐1H‐pyrazole‐3‐acetanilides, before these C‐acylated intermediates had an opportunity to rearrange to anilino‐pyranones, 4‐anilino‐6‐aryl‐2H‐pyran‐2‐ones. J. Heterocyclic Chem., 2010.
Synthesis and structure of new 5‐(arylidene)‐3‐(4‐methylbenzoyl)thiazolidine‐2,4‐diones
Authors: Popov‐Pergal Katarina M. , Poleti Dejan , Rančić Milica P. , Meden Antun , Pergal Marija V. 
Published: January 2010

Abstractmagnified imageThe derivatives of 5‐substituted‐2,4‐thiazolidinedione have a broad spectrum of biological activities. In this article, new 5‐(arylidene)‐3‐(4‐methylbenzoyl)thiayolidine‐2,4‐diones3a,3b,3c,3d,3e,3f,3g,3h,3i,3j,3kwith arylidene groups such as 4‐phenylbenzylidene3a, 3,4‐dimethoxybenzylidene3b, 2‐hydroxybenzylidene3c, 4‐ethoxybenzylidene3d, 5‐methyl‐2‐furfurylidene3e, 4‐dimethylaminobenzylidene3f, 1‐naphthylidene3g, 3,4‐methylenedioxybenzylidene3h, 4‐benzyloxybenzylidene3i, benzylidene3j, and 4‐methoxybenzylidene3k, were synthesized by direct acylation of alkali metal salts of 5‐arylidene‐2,4‐thiazolidinediones with 4‐methylbenzoylchloride. Their structures were confirmed by elemental analysis, IR,1H NMR and MS spectroscopy. In addition, crystal structure of the compound3dwas determined using single‐crystal X‐ray diffraction data. J. Heterocyclic Chem., 2010.
Raman spectroscopic study of the antimonate mineral bottinoite Ni[Sb2(OH)12]·6H2O and in comparison with brandholzite Mg[Sb5+2(OH)12]·6H2O
Authors: Frost Ray L. , Bahfenne Silmarilly 
Published: January 2010

AbstractRaman spectroscopy was used to study the mineral bottinoite and a comparison with the Raman spectra of brandholzite was made. An intense sharp Raman band at 618 cm−1 is attributed to the SbO symmetric stretching mode. The low intensity band at 735 cm−1 is ascribed to the SbO antisymmetric stretching vibration. Low intensity Raman bands were found at 501, 516 and 578 cm−1. Four Raman bands observed at 1045, 1080, 1111 and 1163 cm−1 are assigned to δ SbOH deformation modes. A complex pattern resulting from the overlapping band of the water and hydroxyl units is observed. Raman bands are observed at 3223, 3228, 3368, 3291, 3458 and 3510 cm−1. The first two Raman bands are assigned to water stretching vibrations. The two higher wavenumber Raman bands observed at 3466 and 3552 cm−1 and two infrared bands at 3434 and 3565 cm−1 are assigned to the stretching vibrations of the hydroxyl units. Observed Raman and infrared bands are connected with OH···O hydrogen bonds and their lengths 2.72, 2.79, 2.86, 2.88 and 3.0 Å (Raman) and 2.73, 2.83 and 3.07 Å (infrared). Copyright © 2010 John Wiley & Sons, Ltd.
Preparation of Defined Albumin–Polymer Hybrids for Efficient Cell Transfection
Authors: Zöphel Lukas , Eisele Klaus , Gropeanu Radu , Rouhanipour Ali , Koynov Kaloian , Lieberwirth Ingo , Müllen Klaus , Weil Tanja 
Published: January 2010

AbstractThe preparation of two structurally defined protein–polymer hybrid architectures was presented by connecting two BSA proteins via a bifunctional poly(ethylene oxide) linker. The dimer consisting of native BSA with a negative net charge was characterized in solution as well as on surfaces, and no aggregation was observed. On a surface, defined architectures were found since both BSA subunits were efficiently separated by the PEO chain. After reaction of accessible, negatively charged amino acid residues with ethylenediamine, cBSA‐PEO dimers were achieved with a positive net charge in each subunit. These positively charged polyelectrolytes underwent complex formation with plasmid DNA coding for the luminescent enzyme luciferase. Efficient in vitro gene transfection was obtained with these protein polyelectrolytes and compared with polymer‐based gene transfection agents.magnified image
Molecular‐Weight‐Controlled Brittle‐to‐Semiductile‐to‐Ductile Transition in S‐(S/B)‐S Triblock Copolymers
Authors: Ganß Martin , Satapathy Bhabani K. , Thunga Mahendra , Weidisch Roland , Knoll Konrad 
Published: January 2010

AbstractToughness enhancement of S‐(S/B)‐S triblock copolymers via a molecular‐weight‐controlled pathway is demonstrated. The post‐yield crack toughness behavior of the triblock copolymers uniquely reveal a brittle‐to‐semiductile‐to‐ductile transition with increasing$\overline M _{\rm w}$while keeping the basic molecular architecture fixed. TEM and SAXS investigations indicated three distinct morphologies as a function ofχeffNas a consequence of the increase in$\overline M _{\rm w}$: (i) a homogeneous structure without phase‐separation, (ii) a weakly segregated structure, and (iii) a lamellar structure. The increase in crack toughness is also reaffirmed from kinetic and strain field analysis studies concerning dynamics of crack growth in block copolymers with high PS content.magnified image