bluuebunny/crossref_metadata_2025_split huggingface dataset:
Secreted protein profile from HepG2 cells incubated by S(−) and R(+) enantiomers of chiral drug warfarin – An analysis in cell‐based system and clinical samples
Authors: Bai Jing , Ching Chi Bun , Chowbay Balram , Chen Wei Ning 
Published: September 2010

AbstractPurpose: Warfarin is a commonly prescribed oral anticoagulant with narrow therapeutic index. It interferes with the vitamin K cycle to achieve anti‐coagulating effects. Warfarin has two enantiomers, S(−) and R(+) and undergoes stereoselective metabolism, with the S(−) enantiomer being more effective. Our target is to discover the biological differences of the two enantiomers for better warfarin therapy.Experimental design: We reported the extracellular protein profile in HepG2 cells incubated with S(−) and R(+) warfarin, using iTRAQ‐coupled 2‐D LC‐MS/MS. In addition, clinical sera from 30 patients taken warfarin were also analyzed by the same method as a long‐term batch.Results: In cell line batch in samples incubated with S(−) and R(+) warfarin alone, inter‐α‐trypsin inhibitor heavy chain H4, apolipoprotein A‐I and α‐2‐HS‐glycoprotein showed variations in cells incubated with S(−) warfarin and R(+) warfarin. For other proteins like α‐2‐macroglobulin and Fibrinogen γ chain, the expressions each were found to be the same in cells incubated with either S(−) or R(+) warfarin. Clinical results showed the same trends for protein ratio changes.Conclusion and clinical relevance: Our results indicated that those proteins may interfere with blood coagulation process, as well as contribute to the warfarin's side‐effect response. Taken together, our findings provided molecular evidence on a comprehensive protein profile on warfarin–cell interaction which may shed new lights on future improvement of warfarin therapy.
Theoretical study of ethene hydrogenation reaction on Ir4 tetrahedral cluster
Authors: Tsyshevsky Roman V. , Garifzianova Guzel G. , Aristov Ilia V. , Shamov Alexander G. , Khrapkovskii Grigorii M. 
Published: September 2010

AbstractHydrogenation reaction of ethene on free Ir4 cluster was theoretically investigated using DFT B3LYP level of theory with LanL2Dz basis set. It was found that hydrogen molecule adsorption proceeded without an apparent transition state structure and the adsorption energy was predicted to be −93.7 kJ/mol. Two possible channel of hydrogenation reaction were investigated. Distortion of cluster frame and high values of activation energies make these channels unfavorable. It was shown that inclusion of magnesium oxide (MgO) support model in our calculations account for a considerable variation of geometric parameters of Ir4 cluster. The bonding of a single carbon ligand to the supported tetrahedral Ir4 cluster at the on‐top site was also modeled to probe changes in geometric parameters in comparison with unsupported cluster. © 2010 Wiley Periodicals, Inc. Int J Quantum Chem, 2011
Vibrational corrections to geometry and nuclear shielding constants of cytosine
Authors: Cybulski Sławomir M. 
Published: September 2010

AbstractVibrational corrections to geometry of cytosine were evaluated at several different levels of theory and for several basis sets. The effects of these corrections on bond lengths involving hydrogen atoms as well as bond and dihedral angles involving the amine group were found to be more significant than correlation and basis set effects. A comparison with the bond lengths of C–H and N–H bonds involving cytosine in double stranded DNA structures that were deposited in Nucleic Acid Database showed that the length of both types of bonds in vast majority of structures is underestimated. In addition, the influence of vibrational effects on the shielding constants of all atoms was analyzed. It was found that vibrational averaging lowered the values of shielding constants of all atoms. Particularly, large vibrational corrections were found for nitrogen and oxygen nuclei, but proton shielding was not found to be significantly affected. © 2010 Wiley Periodicals, Inc. Int J Quantum Chem, 2011
On the contribution of mixed terms in response function treatment of vibrational nonlinear optical properties
Authors: Kirtman Bernard , Luis Josep M. 
Published: September 2010

AbstractA new response theory formulation for calculating second‐order vibrational nonlinear optical properties has been recently presented by Hansen et al., J Chem Phys, 2009, 131, 154101. For so‐called mixed terms, this method contains a correction to account for an approximation made in the classic Bishop and Kirtman, J Chem Phys, 1991, 15, 2646 perturbation treatment. This correction vanishes in the static limit and is here shown to vanish also in the high‐frequency limit. The response theory formulation is extended to third‐order properties and, in that case, vanishes in both limits as well. © 2010 Wiley Periodicals, Inc. Int J Quantum Chem, 2011
Design of A New Vibration Transducer for Implantable Middle Ear Hearing Devices
Authors: Seong Ki Woong , Kim Min Woo , Lee Jung Hyun , Kim Myung Nam , Cho Jin Ho 
Published: September 2010

AbstractA new vibration transducer was developed for implantable middle ear hearing devices (IMEHDs). It comprises two permanent magnets positioned inside three coils. The transducer maximizes the interaction between the magnetic fields of the two magnets and the electrical current flowing through the coils. Further, the transducer is robust to external magnetic fields because the magnetic fields inside it are symmetrical. The frequency response was simulated by finite element analysis (FEA). The vibrational displacement of the proposed transducer is 6 dB greater than those of the differential floating mass transducer (DFMT) and the floating mass transducer (FMT). On the basis of these results, a prototype was fabricated and its frequency response was experimentally investigated and compared with simulation results. Finally, it is shown that the proposed transducer has a higher vibrational displacement than the older ones. © 2010 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc.
A Historical Perspective on Market Risks Using the DJIA Index Over One Century
Authors: Zumbach Gilles , Finger Christopher 
Published: September 2010

AbstractThe availability of the Dow Jones Industrial Average (DJIA) index over one century allows an investigation of the stability through time of the statistical properties of this time series, and a measurement of the performance of the main risk evaluation methodologies. The main risk methodologies are presented and discussed. The difference between fundamental limitations (that cannot be changed) and particular implementations (that can be tested and improved) is clearly made. Thanks to the large sample (28850 days), clear conclusions can be reached with simple statistics. In particular, the various risk methodologies perform just according to their respective ingredients used to build the volatility forecast (short versus long memory) and distributional assumption (normal versus fat‐tail). The time stability analysis is carried out using the algorithms developed for risk evaluations. After the volatility is properly discounted, the statistical properties of the DJIA index appear to be extraordinarily stable over time, despite the very significant changes that occurred during the 20th century.
Biominerals—hierarchical nanocomposites: the example of bone
Authors: Beniash Elia 
Published: September 2010

AbstractMany organisms incorporate inorganic solids in their tissues to enhance their functional, primarily mechanical, properties. These mineralized tissues, also called biominerals, are unique organo‐mineral nanocomposites, organized at several hierarchical levels, from nano‐ to macroscale. Unlike man‐made composite materials, which often are simple physical blends of their components, the organic and inorganic phases in biominerals interface at the molecular level. Although these tissues are made of relatively weak components under ambient conditions, their hierarchical structural organization and intimate interactions between different elements lead to superior mechanical properties. Understanding basic principles of formation, structure, and functional properties of these tissues might lead to novel bioinspired strategies for material design and better treatments for diseases of the mineralized tissues. This review focuses on general principles of structural organization, formation, and functional properties of biominerals on the example the bone tissues.WIREs Nanomed Nanobiotechnol2011 3 47–69 DOI: 10.1002/wnan.105This article is categorized under:Implantable Materials and Surgical Technologies > Nanomaterials and ImplantsNanotechnology Approaches to Biology > Nanoscale Systems in Biology
Isolation and characterization of the carbon catabolite‐derepressing protein kinase Snf1 from the stress tolerant yeast Torulaspora delbrueckii
Authors: Hernández‐López María José , Prieto José Antonio , Randez‐Gil Francisca 
Published: September 2010

AbstractWe cloned a genomic DNA fragment of the yeast Torulaspora delbrueckii by complementation of a Saccharomyces cerevisiae snf1Δ mutant strain. DNA sequence analysis revealed that the fragment contained a complete open reading frame (ORF), which shares a high similarity with the S. cerevisiae energy sensor protein kinase Snf1. The cloned TdSNF1 gene was able to restore growth of the S. cerevisiae snf1Δ mutant strain on media containing nonfermentable carbon sources. Furthermore, cells of the Tdsnf1Δ mutant were unable to proliferate under nonfermenting conditions. Finally, protein domain analysis showed that TdSnf1p contains a typical catalytic protein kinase domain (positions 41–293), which is also present in other Snf1p homologues. Within this region we identified a protein kinase ATP‐binding region (positions 48–71) and a consensus Ser/Thr protein kinase active site (positions 160–172). The GenBank Accession No. for the sequenced DNA fragment is HM131845. Copyright © 2010 John Wiley & Sons, Ltd.
Systematische Studie zu den Koordinationseigenschaften des Guanidin‐Liganden Bis(tetramethylguanidino)propan mit den Metallen Mangan, Cobalt, Nickel, Zink, Cadmium, Quecksilber und Silber
Authors: Neuba Adam , Herres‐Pawlis Sonja , Seewald Oliver , Börner Janna , Heuwing Andreas J. , Flörke Ulrich , Henkel Gerald 
Published: September 2010

AbstractThe transition metal complexes with the ligand 1,3‐bis(N,N,N′,N′‐tetramethylguanidino)propane (btmgp), [Mn(btmgp)Br2] (1), [Co(btmgp)Cl2] (2), [Ni(btmgp)I2] (3), [Zn(btmgp)Cl2] (4), [Zn(btmgp)(O2CCH3)2] (5), [Cd(btmgp)Cl2] (6), [Hg(btmgp)Cl2] (7) and [Ag2(btmgp)2][ClO4]2·2MeCN (8), were prepared and characterised for the first time. The stoichiometric reaction of the corresponding water‐free metal salts with the ligand btmgp in dry MeCN or THF resulted in the straightforward formation of the mononuclear complexes 1–7 and the binuclear complex 8. In complexes with MII the metal ion shows a distorted tetrahedral coordination whereas in 8, the coordination of the MI ion is almost linear. The coordination behavior of btmgp and resulting structural parameters of the corresponding complexes were discussed in an comparative approach together with already described complexes of btmgp and the bisguanidine ligand N1,N2‐bis(1,3‐dimethylimidazolidin‐2‐ylidene)‐ethane‐1,2‐diamine (DMEG2e), respectively.
(Ba6O)(ReN3)2: Synthesis, Crystal Structure and Physical Properties
Authors: Schmidt C. L. , Dinnebier Robert , Jansen Martin 
Published: September 2010

AbstractThe reaction of a mixture of barium and rhenium (3:1) at 850 °C under flowing nitrogen yielded the nitride‐oxide (Ba6O)(ReN3)2 (R$\bar{3}$ (No. 148); a = 8.1178(2) Å, c = 17.5651(4) Å; V = 1002.43(5) Å3; Z = 6). According to a structure refinement on X‐ray powder diffraction data, this compound is isostructural to a recently described nitride‐oxide of osmium of analogous composition. The structure consists of sheets of trigonal ReN3 units and trigonal antiprismatic Ba6O groups. The Ba–O distance of 2.73 Å is close to the sum of the respective ionic radii. The trigonal ReN35– nitride anion displays a Re–N bond length of 1.94 Å, and is planar within the limits of experimental error. The constitution of the anion was confirmed by IR and Raman spectroscopy. The nitride‐oxide is stable up to 1000 °C, semiconducting (σ = 4.57 × 10–3 Ω–1·cm–1 at RT), and paramagnetic down to 25 K. A Curie–Weiss analysis resulted in a magnetic moment of μ = 0.68 μB per rhenium atom.
Asymptotic fields ahead of mixed mode frictional cohesive cracks
Authors: Karihaloo B.L. , Xiao Q.Z. 
Published: September 2010

AbstractThis paper discusses the asymptotic fields ahead of mixed mode frictional cohesive cracks in quasi‐brittle materials. These fields have been derived after reformatting the cohesive‐law in a special but universal polynomial containing fractional or integer powers. This special form ensures that the radial and angular variations of the asymptotic fields are separable as in the Williams expansions for a traction‐free crack. The coefficients of the expansions however depend nonlinearly on the softening law and the boundary conditions. As expected, the asymptotic field of a frictional cohesive crack reduces to that of a frictionless cohesive crack with normal cohesive separation when the friction coefficient becomes zero. It is also shown that the asymptotic field of a frictionless cohesive crack can be used to a non‐cohesive crack opened by crack face loading, after including the singular terms corresponding to the eigenvalue 1/2. Furthermore, the coefficients are given explicitly for two special softening laws that are commonly used in practice. The leading terms of the true displacement asymptotic field are also derived explicitly. These are especially useful as the enrichment functions at the tip of a mixed mode cohesive crack for accurate simulation of crack growth in quasi‐brittle materials using the extended finite element (XFEM).
Prognostic Impact of Extrathyroid Extension and Clinical Lymph Node Metastasis in Papillary Thyroid Carcinoma Depend on Carcinoma Size
Authors: Fukushima Mitsuhiro , Ito Yasuhiro , Hirokawa Mitsuyoshi , Miya Akihiro , Shimizu Kazuo , Miyauchi Akira 
Published: September 2010

AbstractBackgroundAlthough papillary thyroid carcinoma (PTC) generally has an indolent nature, massive extrathyroid extension (Ex) and clinical lateral node metastasis (N1b) are prominent predictors of a dire prognosis. However, it remains unknown whether these factors affect patient prognosis with uniformity. In this study, we investigated the relationships between the prognostic impact of these factors and carcinoma size.MethodsA total of 5,917 patients who underwent initial and curative surgery for PTC between 1987 and 1995 were enrolled in this study. After dividing these patients into four subsets based on tumor size—≦1.0 cm, 1.1–2.0 cm, 2.1–3.0 cm, and >3.0 cm—we investigated the prognostic impacts of Ex and N1b in each subset.ResultsRelative risk (RR) of disease‐free survival (DFS) of N1b was the highest in the subset ≦1.0 cm and decreased with tumor size. RR of Ex was smaller in carcinoma ≦3.0 cm but larger in carcinoma >3.0 cm compared with that of N1b in the respective subsets. On multivariate analysis, N1b was a more important prognostic factor than Ex in carcinoma ≦3.0 cm, but the prognostic impacts of these two factors were reversed in carcinoma >3.0 cm. Similar findings were obtained in analyses for cause‐specific survival (CSS) and prognostic value of N1b was more significant in carcinoma ≦3.0 cm but less significant in carcinoma >3.0 cm than that of Ex.ConclusionsThe prognostic values of Ex and N1b vary with tumor size in PTC. It is important for physicians to pay attention to tumor size when evaluating the prognostic impact of these two prominent factors.
Changing Approaches to Cholecystectomy in Elderly Patients: A 10‐Year Retrospective Study in Taiwan
Authors: Shi Hon‐Yi , Lee King‐Teh , Uen Yih‐Huei , Chiu Chong‐Chi , Lee Hao‐Hsien 
Published: September 2010

AbstractBackgroundThe prevalence of symptomatic gallbladder diseases increases with age. The present study evaluated cholecystectomy risk factors and hospital resource utilization in an elderly (aged 60 years and older) population of patients who had undergone open cholecystectomy (OC) or laparoscopic cholecystectomy (LC).MethodsThe study analyzed 20,538 OC and 29,318 LC procedures performed in Taiwan from 1996 to 2007. Odds ratio (OR) and 95% confidence interval were calculated to assess the relative change rate. Regression models were employed to predict length of stay (LOS) and total surgical cost.ResultsPatient characteristics associated with increased likelihood of undergoing LC were age 60–69 years, female gender, and lack of current co‐morbidities. Length of stay associated with both OC and LC decreased during the study period. Total surgical cost for elderly OC patients increased during the study period, whereas that for elderly LC patients declined. Compared to OC patients, LC patients had significantly larger changes in LOS (−2.27 days) and total surgical cost ($ −368.64 U.S. dollars) (p < 0.001). The following factors were associated with considerable increases in both LOS and total surgical cost: advanced age, female gender, presence of one or more co‐morbidities, treatment in a regional or a district hospital, and long LOS.ConclusionsDecreases in hospital resource utilization were larger in elderly LC patients than in elderly OC patients. Health care providers and patients should observe that hospital resource utilization may depend on hospital attributes as well as patient attributes. These analytical results should be applicable to similar elderly populations in other countries.
Ant–plant interaction in the Neotropical savanna: direct beneficial effects of extrafloral nectar on ant colony fitness
Authors: Byk Jonas , Del‐Claro Kleber 
Published: September 2010

AbstractCurrent evidence suggests that ant–plant relationships may influence species composition, abundance, and interactions at the community scale. The main resource that plants offer to ants is extrafloral nectar (EFN) and the major part of published studies shown benefits from ants to plants possessing EFNs. However, the complementary question of whether and how ants benefit from EFNs is rarely addressed. Here, we present the results of a long‐term study to demonstrate whether EFN has a positive effect on ant colony fitness. We quantified colony growth rate, survival and the final weight of individuals as measures of benefit derived from EFN. Our results provide clear evidence that EFN can have a significant positive impact on the survivorship, growth and reproduction of the Myrmicinae Cephalotes pusillus. In fact, a diet rich in EFN (providing at least 30 cal per day) resulted in five times more individuals per colony, greater body weights, and more eggs. These results have shed new light on the relationships between ants and EFN‐bearing plants such as in tropical and temperate systems. The ant C. pusillus is the first case in which we have firm evidence that EFN improves colony growth and development, corroborating more than 100 years of experimental evidence of benefits to plants in these widespread relationships.
What ‘anorogenic’ igneous rocks can tell us about the chemical composition of the upper mantle: case studies from the circum-Mediterranean area
Authors: LUSTRINO MICHELE 
Published: September 2010

AbstractThe composition of the upper mantle bounded by the Canaries, Eastern Anatolia, Libya and Poland is indirectly investigated by means of the chemical composition of igneous rocks with ‘anorogenic’ geochemical characteristics emplaced during the Cenozoic. The relatively homogeneous composition of these products in terms of incompatible trace-element content and Sr–Nd–Pb isotopic composition is unexpected, considering the variable lithospheric structure of this large area and the different tectono-thermal histories of the various districts. In order to reconcile the geochemical characteristics with a statistical sampling model, it would be necessary to propose volumes of the enriched regions much lower than the sampling volumes for each volcano (that is, less than 10 cubic metres), or alternatively, efficient magma blending from larger areas. The data are consistent with a relatively well-stirred and mixed sub-lithospheric upper mantle, in the solid state, which is also hard to understand. This contrasts with the situation under oceans where magma blending from diverse sources and sampling theory can explain the compositional statistics.
Abraham geschworen – uns gegeben. Syntax und Sinn im Benediktus (Lukas 1.68–79)
Authors: Lang Friedrich Gustav 
Published: September 2010

The Benedictus is Luke's own composition. Its syntax is perspicuous, provided that 1.71 is understood aszeugmaand 1.73 ashyperbaton. It has three parts in 3 + 5 + 5 double lines; their topics are eschatological (1.68–70: messianic hopes), ecclesiological (1.71–75: God's covenant) and soteriological (1.76–79: remission of sins). The oath sworn to Abraham and granted to ‘us’ (1.73) forms the centre. The hymn originates in Luke's sophisticated theological reflection, his knowledge of LXX, and his literary skill which is confirmed by the stichometric proportions of the passage.
Multiple-locus variable-number tandem-repeat analysis for discriminating withinSalmonella entericaserovar Typhimurium definitive types and investigation of outbreaks
Authors: DYET K. H. , TURBITT E. , CARTER P. E. 
Published: September 2010

SUMMARYThe discriminatory power of multiple-locus variable-number tandem-repeat analysis (MLVA) needs to be evaluated for allSalmonella entericasubspeciesentericaserovar Typhimurium (S. Typhimurium) phage types so that the power of this methodology is understood and results can be interpreted correctly during outbreak investigations. We evaluated the ability of MLVA to characterize four definitive phage types (DT) problematic in New Zealand. MLVA discriminated between DT104 isolates although there was very limited variation in the MLVA profiles for isolates with an RDNC phage type (reacts but does not conform to a recognized Typhimurium phage pattern) first observed in New Zealand's Enteric Reference Laboratory in May 2006. Most DT101 isolates had indistinguishable MLVA profiles or profiles that differed at one or two loci. This was also observed in DT160 isolates. MLVA may not identify all common-source outbreaks although it provided valuable data when applied to case isolates from twoS. Typhimurium outbreaks.