bluuebunny/crossref_metadata_2025_split huggingface dataset:
Análisis de la efectividad de los jugadores de pádel profesional en función de su altura y zona de golpeo
Authors: Ortega-Caballero Manuel , Torres-Malagón Cristian , Sánchez-García Marta , Ferreri-Acosta Franco 
Published: June 2024

The main purpose of this research is to analyze the correlation between male and female World Padel Tour (WPT) players during the 2022 season, in anthropometric, tactical and effective variables on the court. Anthropometric indicators were collected (sex, age) and effectiveness reflected in the WPT statistical database. Both anthropometric data and effectiveness and sex were analyzed. A sample of 400 ranked players (200 men and 200 women) was used. The research shows that there is a significant difference between the forehand and backhand zones of play, with the partner's drive being more effective. The research provides us with information of interest, mainly in the profile of the players, stating the height of the players as a non-cardinal factor for sports performance or the different forms of pairing in the male and female professional circuit, with the male being more even in age.
The Implementation of Adapted Physical Education at the End of the Pandemic: A Learning Evaluation
Authors: Burhaein Erick , Pratidina Amalia , Putri Antika Pramesti Maharani , Samudra Indah Hapsari , Wardani Luri Kusuma , Pratama Roihan Syafiq 
Published: June 2024

The prolonged pandemic period requires adaptive physical education teachers in Special Schools to do adjustments quickly to ensure that the learning process can run smoothly and learning objectives can be achieved. The purpose of this study was to analyze the implementation of adaptive physical education learning evaluation at the end of the pandemic. The research method used was the qualitative method with a phenomenological approach. The respondents were 20 active adaptive physical education teachers in Banjarnegara and Wonosobo regencies. Data collection instruments included documentation sheets, observations, and unstructured interviews. The results of this study showed that the education at the end of the Covid-19 pandemic was carried out online. The analysis of the findings is presented in 3 dimensions, namely 1) student engagement, 2) learning support, and 3) learning barriers. The evaluation used unstandardized observation rubric. It concludes that adaptive physical education learning in Special Schools during the pandemic was adjusted to the situation and conditions of the students. Cooperation between teachers and guardians is the key to a successful learning.
Resistance to cephalosporins and quinolones by <i>Escherichia coli</i> isolated from irrigation water from eastern Lima, Perú
Authors: Huamán Iturrizaga Mónica , Salvador-Luján Gina , Morales Liliana , Luna Jeanne Alba , Velasquez Garcia Lino , Pacheco Perez Julio Daniel , Pons Maria J. 
Published: June 2024

Objetivos. Evaluar la presencia y sensibilidad a los antimicrobianos de cepas de Escherichia coli aisladas de 24 muestras de agua de riego del río Rímac de Lima Este, Perú. Materiales y métodos. Las cepas de E. coli fueron identificadas por PCR. La susceptibilidad a los antibióticos se procesaron por el método de difusión en disco. Los genes implicados en betalactamasas de espectro extendido (BLEE), quinolonas y virulencia se determinaron por PCR. Resultados. Todas las muestras superaron los límites permisibles establecidos en las Normas de Calidad Ambiental para el riego de hortalizas. De los 94 aisaldos, el 72,3% mostró resistencia al menos a un antibiótico, el 24,5% eran multirresistentes (MDR) y el 2,1% extremadamente resistentes. Los mayores porcentajes de resistencia se observaron para ampicilina-sulbactam (57,1%), el ácido nalidíxico (50%), trimetoprim-sulfametoxazol (35,5%) y ciprofloxacino (20,4%). Entre los aislados, el 3,2% presentaba fenotipo BLEE relacionado con el gen bla CTX-M-15. Los mecanismos transferibles de resistencia a las quinolonas, qnrB fueron más frecuentes (20,4%), y el 2,04% tenían el qnrS. Se calcularon que el 5,3% eran E. coli diarreagénicas y de estas, el 60% eran E. coli enterotoxigénicas, el 20% E. coli enteropatógenas y el 20% E. coli enteroagregantes. Conclusiones. Los resultados muestran la existencia de patotipos diarreogénicos en el agua utilizada para el riego de productos frescos y destaca la presencia de E. coli productores de BLEE y MDR, demostrando el papel que juega el agua de riego en la diseminación de genes de resistencia en el Perú.
Blood flow restriction resistance training as an alternative to resistance training alone to improve strength in elderly: a systematic review with meta-analysis
Authors: Mallmann André Luiz Silveira , Santos Leonardo Peterson dos , Doria Lucas Denardi , Ferreira Luis Fernando , Ramis Thiago Rozales , Da Rosa Luis Henrique Telles 
Published: June 2024

The purpose of this research was to perform a systematic review with meta-analysis to compare the effects of resistance training with blood flow restriction (BFR) to the effects of non-training (CON) and traditional resistance training (RT) on strength in elderly people. This was a systematic review with meta-analysis of randomized clinical trials (RCTs), published in English, from inception to 2022, conducted using MEDLINE (PubMed), EMBASE, Web of Science and Cochrane Library. The methodological quality was assessed using GRADE protocol. The risk of bias was assessed using RoB2 software. Standardized mean differences (SMD), mean difference, were pooled using a random-effects model. A p < 0.05 was considered statistically significant. Eight RCT’s were included. We found no significant differences in the effects between BFR and RT (SMD = -0.18 [-0.56 to 0.19]; p = 0.34; I2 = 12%). Also, evidence from our research shows that the effect of BFR is better than non-training (CON) for strengthening in older adults (SMD = 0.63 [0.24 to 1.01]; p = 0.001; I2 = 11%). Our primary findings show that training with BFR may be an alternative methodology of training for the elderly and this training strategy may be interesting for health professionals working with elderly people with low tolerance to high intensity RT.
Audit Atas Piutang Usaha PT X
Authors: Budi Sulistia Aldy Ryan , Neni Meidawati  
Published: June 2024

Audit merupakan prosedur sistematis untuk mengumpulkan dan menilai bukti yang berkaitan dengan pernyataan tentang aktivitas dan kejadian ekonomi yang beragam secara tidak memihak atau independent. Artikel ini mereview bagaimana prosedur audit dilakukan oleh suatu kantor akuntan publik terutama dibagian piutang usaha. Penelitian ini bertujuan untuk mengetahui gambaran umum prosedur audit piutang oleh KAP Dian Utami dimulai dari tahap perencanaan, tahap pelaksanaan, dan tahap pelaporan audit bagi PT X yang dilakukan oleh KAP Dian Utami di Yogyakarta. Penelitian ini merupakan penelitian kualitatif dengan pendekatan Observasi dan wawancara. Pengumpulan data dilakukan dengan metode observasi, wawancara, dokumentasi, dan kepustakaan. Analisis data dilakukan dengan Teknik analisis deskriptif yaitu dengan melakukan pengamatan, pembicaraan, dan bahan tertulis. Hasil penelitian yang dilakukan yaitu Prosedur audit pada KAP Dian Utami terhadap PT X sudah dilakukan dengan baik dan sesuai dengan peraturan dan ketentuan yang berlaku. Auditor menjalakan tugasnya tanpa memihak kepada siapapun, sehingga hasil audit dapat dikatakan benar karena sesuai dengan keadaan sebenarnya
Genetic influence on bone mineral density for Japanese women: a twin study
Authors: Saeki Soichiro , Tomizawa Rie , Minamitani Kaori , Nakata Ken , Honda Chika 
Published: June 2024

Abstract

Background
Osteoporosis is a major risk factor for fractures among the elderlies. Despite osteoporosis being a significant concern in super-aged societies such as Japan, the heritability of bone mineral density within the Japanese populace remains unexplored.
Methods
The bone area ratio (BAR, %) of 298 healthy, female Japanese twins (comprising 149 pairs, 136 monozygotic and 13 dizygotic twin pairs) registered in the Osaka University Twin Registry was measured using quantitative ultrasound. Classical twin analysis was employed to ascertain the heritability of bone mineral density.
Results
The heritability of bone mineral density for the entire cohort was 0.51 (95% confidence intervals (CI) 0.38–0.63). For the subset of subjects younger than 50 years, the effects of menopause were adjusted, and the best-fit model was also found to be the AE model, with a heritability estimate of 0.53 (95% CI: 0.34–0.72).
Conclusions
Compared to women from other countries, Japanese women appear to exhibit relatively lower heritability of bone mineral density. Consequently, environmental factors may exert a more significant influence on osteoporosis in Japanese women compared to women of other races and ethnicities.
Bioinspired Capillary Force-Driven Super-Adhesive Filter
Authors: Wooh Sanghyuk , Park Junyong , Moon Chan Sik , Lee Ji Min , Rahat Sazzadul , Kim Sang Moon , Pham Jonathan , Kappl Michael , Butt Hans-Jürgen 
Published: June 2024

Abstract

Capturing particles with low, nanonewton scale adhesion is an ongoing challenge for conventional air filters1,2. Inspired by the natural filtration capabilities of mucus-coated nasal hairs3-7, we introduce an efficient biomimetic filter that exploits a thin liquid coating. Here, a stable thin liquid layer is formed on a variety of filter media that generates enhanced particulate adhesion, driven by micro- to sub-micronewton capillary forces8,9. The enhanced particle adhesion results in outstanding filtration of airborne particulates while maintaining air permeability, providing longer filter lifetime and increased energy savings. Moreover, strong adhesion of the captured particles enables effective filtration under high-speed airflow as well as suppression of particle redispersion. We anticipate that these filters with thin liquid layers affords a new way to innovate PM filtering systems.
BanTrafficNet: Bangladeshi Traffic Sign Recognition Using A Lightweight Deep Learning Approach
Authors: Tusher Md Mahbubur Rahman , Farid Fahmid Al , Kafi Hasan Muhammad , Miah Abu Saleh Musa , Rinky Susmita Roy , Islam Muhiminul , Rahim Md. Abdur , Mansor Sarina , Karim Hezerul Abdul 
Published: June 2024

Abstract

Traffic sign recognition is a critical aspect of intelligent transportation systems that enhances road safety, traffic management, and driver assistance. Notably, while significant research efforts have been devoted to many prevalent traffic signs, Bangladeshi sign recognition remains relatively underexplored due to a lack of traffic sign knowledge and the unawareness of the sector individuals. The scarcity of Bangladeshi traffic sign datasets has exacerbated this limitation, hindering progress. Moreover, most Bangladeshi traffic sign research predominantly relies on a limited number of signs, leading to diminished accuracy and the inability to detect all traffic signs. Additionally, existing systems grapple with suboptimal performance accuracy and heightened computational complexity, further emphasizing the research gap. To address these formidable challenges, we propose a robust Bangladeshi traffic sign recognition system using a deep learning-based CNN architecture. The main aim is to create a lightweight model that helps identify traffic signs correctly with less computational effort. We used the effective combination of various deep learning layers in the proposed system. A significant contribution of our work lies in creating a novel Bangladesh Traffic Sign Recognition (BDTSR) dataset, addressing the scarcity of data in this domain. This dataset comprises comprehensive information, including 48 types of traffic signs, and these images were taken from different roads in the country. Our dataset aims to fill a critical gap in Bangladeshi traffic sign research and provides a solid foundation for more extensive and inclusive studies in the field. Through this innovative approach, we aim to contribute significantly to the field of BDTSR, filling the gaps in traffic sign recognition and bolstering the accessibility of traffic signs within the Bangladeshi individual traffic community and beyond. Our evaluation of the newly created BDTSR dataset and the existing two benchmark datasets resulted in high recognition accuracies of 99.34\%, 96.97\% and 98.82\% accuracies for the BDTSR, German Traffic Sign Recognition Benchmark (GTSRB) and the Belgian Traffic Sign Dataset (BTSC) respectively. These resultshighlight the superiority of our model in the Bangladeshi Traffic Sign Recognition domain, outperforming existing models in terms of accuracy and computational efficiency.
The extent and pattern of symptom relief after surgical castration for patients with advanced prostate cancer treated at a Muhimbili National Hospital.
Authors: Nhungo Charles John , Sensa Victor Patrick , Mushi Fransia Arda , Njiku Kimu Marko , Mwanga Ally Hamis , Mkony Charles , Alexandre Amini Mitamo , Lori Joseph Martin 
Published: June 2024

Abstract

Background: Advanced prostate cancer leads to many symptoms, notably bone pain and lower urinary tract symptoms; however, the degree and duration of pain relief, changes in LUTs severity and underlying factors that predict the extent of relief remain inadequately understood. Surgical castration has proven effective in relieving bone pain and urinary symptoms.

Objective: To determine the extent and pattern of symptom relief in advanced prostate cancer patients following surgical castration at Muhimbili National Hospital.

Methods: A prospective cohort study was conducted at MNH for a period of 6 months, and patients were followed for 30days. The international prostate symptoms score tool was used for LUTs assessment, and the pain rating scale was used for assessing bone pain symptoms before and after surgery. Cross-tabulation with chi-square tests as a measure of association was used to test differences in pain relief across different participant characteristics. Modified Poisson regression was used to determine factors associated with complete bone pain relief. Both bivariate and multivariable analyses were performed. A p-value<0.05 was considered to indicate statistical significance.
Results.
A total of 210 participants with a mean age of 72.3 years were recruited. The mean LUTs before surgical castration was 15.1 (95% CI 14.4 to 15.7), which was significantly greater than that after surgical castration (mean score 8.0, 95% CI 7.4 to 8.6), representing a decrease of 7.1 (95% CI 6.4 to 7.7, p<0.001). The mean score for bone pain before surgical castration was 74.3 (95% CI 72.4 to 76.3), and that after surgical castration was 34.5 (95% CI 30.6 to 38.4). There was an absolute decrease of 39.8% (95% CI 34.7 to 44.9, p<0.001) in the bone pain score after surgical castration, and more than half of the patients 111 (52.9%) reported bone pain relief within the first two weeks.
Conclusion.
Surgical castration affects both bone pain control and lower urinary tract symptoms in patients with advanced prostate cancer. Additionally, more studies should be conducted to assess the duration of bone pain relief after surgical castration.
Novel 11β-HSD1 inhibitor ameliorates liver fibrosis by inhibiting the Notch signaling pathway and increasing the NK cell population.
Authors: Jun Dae Won , Yoon Taehyun , KIM JiEun , Kim Yun , Bae Jiwon , Yoon Eileen Laurel , Kim Hyun Sung , Lee Sungryol 
Published: June 2024

Abstract

11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) regulates hepatic glucose output and systemic glucose homeostasis. We aimed to investigate the anti-fibrotic effect of a novel 11β-HSD1 inhibitor in a liver fibrosis mouse model. Hepatic fibrosis animal model was induced by thioacetamide administration during 19 weeks. Bulk RNA sequencing was performed to evaluate mode of action. Changes of immune cell distribution was evaluated using mass cytometry in peripheral blood. 11β-HSD1 inhibitor treatment group showed a significant decrease in the fibrosis area and alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels compared with the thioacetamide induced hepatic fibrosis animal model. Bulk RNA sequencing data showed Notch signal decreased and natural killer (NK) cell pathway increased after 11β-HSD1 inhibitor treatment. Changes of NK cell population was reconfirmed by mass cytometry in In Vivo animal models, and expression of Notch ligands (Jag2, Dll1, Dll3, and Dll4), Notch signals (Hes1 and Sox9), and Notch receptors (Notch3 and Notch4) decreased after 11β-HSD1 inhibitor treatment. Therefore, the novel 11β-HSD1 inhibitor ameliorates liver fibrosis by inhibiting the Notch signaling pathway and increasing the NK cell population.
Females codling moths evade the mating disruption control tactic
Authors: Sharon Rakefet , Tomer Maor , Avraham Almog , Harari Ally R 
Published: June 2024

Abstract

Mating disruption, an environmentally friendly pest-control method, utilizes synthetic sex pheromones to interfere with males' ability to locate females for mating. An increase in successful mate encounters can occur due to uneven distribution of synthetic pheromones in the field, allowing males to locate and mate with calling females in areas of low pheromone concentration and areas with larger pest populations, where random encounters between males and females are more likely to happen by chance.
The study results demonstrate greater fruit damage and higher abundances of male and female codling moths (Cydia pomonella)in the margins compared to the centers of mating disruption-treated apple orchards.
We suggest larger pest populations build up at the orchard margins over the season due to the following behavioral cascade: Females flee areas of high pheromone concentration to reduce the perceived “competition” for mates, while mated females move to the margins to minimize future “competition” for offspring's resources. Males then track the higher female population at the margins by following the females' full pheromone blend.
To our knowledge, this is the first study to offer an interpretation supported by empirical data for the puzzling phenomenon of higher fruit damage in field margins under mating disruption.
The potential role of cuproptosis-related genes for therapy and immunoregulation in pan-cancer
Authors: Zhou Jianpeng , Wang Chuanlei , Li Jia , Wang Guangyi 
Published: June 2024

Abstract

The primary drawbacks of current cancer therapies are lower selectivity for cancer cells, more side effects, and obscure resistance mechanisms. Novel approaches to overcome these drawbacks comprise the utilization of ionophores and metalliferous chelators to change the concentration of trace metal elements in cancer cells. As the concept of cuproptosis emerged, it might be a novel strategy to enhance the curative effects for resistant cancer cells potentially. FDX1, LIAS, LIPT1, DLD, DLAT, PDHA1, PDHB, and SLC31A1 are the major regulators of cuproptosis. However, the expression landscape and clinical roles of these regulators remain to be addressed. This study explored the expression pattern and clinical role of these cuproptosis-related genes in pan-cancer by evaluating the association of tumor mutation burden, immune-related scores, cells in tumor microenvironment, and drug sensibility. The results displayed that the expressions of cuproptosis-related genes were significantly different in various cancer types, all cuproptosis-related gene upregulates significantly in LAML, ALL, PAAD, GBM, GBMLGG, LGG, and all significantly downregulated in cancers KIPP, WT, KIPAN, KIRC. Furthermore, the higher the level of cuproptosis-related genes expressed, the higher the survival in patients suffering from KIRC, and KIPAN increased. In addition, the expression of cuproptosis-related genes was negatively associated with immune-related scores, while SLC31A1 had a positive association with StromalScore, ImmuneScore, and EstimateScore in LAML. Importantly, the level of cuproptosis-related gene expressions is positively associated with CLP cells or Th2 cells, but negatively associated with NKT cells or Th1 cells. In summary, cuproptosis-related genes are disordered in various cancer types have prognostic value for different cancers, and also can evaluate the cells infiltrating in tumor microenvironment.
Caspase-8-mediated inflammation but not apoptosis drives death of retinal ganglion cells and loss of visual function in glaucomaa
Authors: Guo Yinjie , Verma Bhupender , Shrestha Maleeka , Marshak-Rothstein Ann , Gregory-Ksander Meredith 
Published: June 2024

Abstract

Background
- Glaucoma is a complex multifactorial disease where apoptosis and inflammation represent two key pathogenic mechanisms. However, the relative contribution of apoptosis versus inflammation in axon degeneration and death of retinal ganglion cells (RGCs) is not well understood. In glaucoma, caspase-8 is linked to RGC apoptosis, as well as glial activation and neuroinflammation. To uncouple these two pathways and determine the extent to which caspase-8-mediated inflammation and/or apoptosis contributes to the death of RGCs, we used the caspase-8 D387A mutant mouse (Casp8DA/DA) in which a point mutation in the auto-cleavage site blocks caspase-8-mediated apoptosis but does not block caspase-8-mediated inflammation.
Methods-
Intracameral injection of magnetic microbeads was used to elevate the intraocular pressure (IOP) in wild-type, Fas deficient Faslpr, and Casp8DA/DA mice. IOP was monitored by rebound tonometry. Two weeks post microbead injection, retinas were collected for microglia activation analysis. Five weeks post microbead injection, visual acuity and RGC function were assessed by optometer reflex (OMR) and pattern electroretinogram (pERG), respectively. Retina and optic nerves were processed for RGC and axon quantification. Two- and five-weeks post microbead injection, expression of the necrosis marker, RIPK3, was assessed by qPCR.
Results-
Wild-type, Faslpr, and Casp8DA/DA mice showed similar IOP elevation as compared to saline controls. A significant reduction in both visual acuity and pERG that correlated with a significant loss of RGCs and axons was observed in wild-type but not in Faslpr mice. The Casp8DA/DA mice displayed a significant reduction in visual acuity and pERG amplitude and loss of RGCs and axons similar to that in wild-type mice. Immunostaining revealed equal numbers of activated microglia, double positive for P2ry12 and IB4, in the retinas from microbead-injected wild-type and Casp8DA/DA mutant mice. qPCR analysis revealed no induction of RIPK3 in wild-type or Casp8DA/DA mice at two- or five-weeks post microbead injection.
Conclusions-
Our results demonstrate that caspase-8-mediated extrinsic apoptosis is not involved in the death of RGCs in the microbead-induced mouse model of glaucoma implicating caspase-8-mediated inflammation, but not apoptosis, as the driving force in glaucoma progression. Taken together, these results identify the caspase-8-mediated inflammatory pathway as a potential target for neuroprotection in glaucoma.