bluuebunny/crossref_metadata_2025_split huggingface dataset:
Addressing the business of discharge: Building a case for an electronic discharge summary
Authors: Mourad Michelle , Cucina Russell , Ramanathan Rajiv , Vidyarthi Arpana R. 
Published: September 2010

AbstractHospitalists are increasingly involved in implementing quality improvement initiatives around patient safety, clinical informatics, and transitions of care, but may lack expertise in promoting these important interventions. Developing a sound business case is essential to garnering support and resources for any quality improvement initiative. We present a framework for developing a business case using a structured approach to exploring qualitative and quantitative costs and benefits and describe its application in the experience of developing an electronic discharge summary at the University of California San Francisco (UCSF). At our institution, we found that the primary financial benefits are the cost reductions in eliminating transcription needs and decreasing billing delays, as well as reducing the cost of tracking completion of and dissemination of discharge summaries. Costs incurred from a new information technology (IT) infrastructure, programmer time, maintenance and training must also be accounted for. While benefits may be apparent to front line providers (improved communication, efficiency of data transfer, and increased referring physician satisfaction), implementing and sustaining such an innovation depends on articulating a sound business case with a detailed cost‐benefit analysis to institutional decision making. Journal of Hospital Medicine 2011. © 2010 Society of Hospital Medicine.
Mineral‐nutrient synergism and dilution responses to nitrogen fertilizer in field‐grown maize
Authors: Riedell Walter E. 
Published: September 2010

AbstractNitrogen (N)‐fertilizer applications to field‐grown maize may result in a dilution response whereby essential mineral‐element concentrations in shoots would decrease as shoot‐dry‐matter accumulation increased. To investigate this, the effect of N‐fertilizer treatments (no N or fertilizer rate based upon 5.3 or 8.5 t ha–1 yield goal) on maize (Zea mays L.) shoot dry weight and shoot mineral concentrations (N, P, K, S, Mg, Ca, and Mn) at the sixth leaf (V6), twelfth leaf (V12), and tassel (VT) development stages were investigated in a 2‐year study conducted at Brookings, South Dakota (USA). With increasing N‐fertilizer application rates, shoot dry weight was greater and shoot P and K concentrations decreased. A possible explanation of this dilution response is that planting‐time P and K fertilizers, which were applied in a band near the seed furrow, may have enhanced the uptake of P and K in a manner that was independent of N‐fertilizer treatments. Increased shoot‐dry‐weight production due to the application of N fertilizers, if P and K uptake were similar across N‐fertilizer treatments, would lead to decreased shoot P and K concentrations in N‐sufficient compared with N‐deficient plants. Conversely, N‐fertilizer‐induced increases in shoot dry weight were accompanied by increased shoot concentrations of N, Ca, and Mn. This synergistic response between dry‐weight accumulation and shoot N concentration was present at all leaf developmental stages studied, while that for Ca was present only at VT. Thus, N fertilizer applications that increase shoot dry weight can affect the dilution and synergistic responses of specific mineral nutrients in maize shoots. Crop developmental stage as well as the location of these specific mineral nutrients in the soil profile might play important roles in mediating these responses.
Surgical outcomes for liposarcoma of the lower limbs with synchronous pulmonary metastases
Authors: Illuminati Giulio , Ceccanei Gianluca , Pacilè Maria Antonietta , Calio Francesco G. , Migliano Francesco , Mercurio Valentina , Pizzardi Giulia , Nigri Giuseppe 
Published: September 2010

AbstractBackground and ObjectivesSurgical resection of pulmonary metastases from soft tissues sarcomas has typically yielded disparate results, owing to the histologic heterogeneity of various series and the presentation times relative to primary tumor discovery. It was our hypothesis that with expeditious, curative surgical resection of both, primary and metastatic disease, patients with liposarcoma of the lower limb and synchronous, resectable, pulmonary metastases might achieve satisfactory outcomes.MethodsA consecutive sample clinical study, with a mean follow‐up duration of 30 months. Twenty‐two patients (mean age, 50 years), each presenting with a liposarcoma of the lower limb and synchronous, resectable, pulmonary metastases, underwent curative resection of both the primary mass and all pulmonary metastases within a mean of 18 days from presentation (range 9–32 days).ResultsMean overall survival was 28 months, disease‐related survival (SE) was 9% at 5 years (±9.7%), and disease‐free survival was 9% at 5 years (±7.6%).ConclusionExpeditious, curative resection of both—primary and metastatic lesions—yields acceptable near‐term results, with potential for long‐term survival, in patients with liposarcoma of the lower limb and synchronous pulmonary metastases. J. Surg. Oncol. 2010;102:827–831. © 2010 Wiley‐Liss, Inc.
Lymphatic micrometastases in patients with early esophageal adenocarcinoma
Authors: Grotenhuis Brechtje A. , van Heijl Mark , Wijnhoven Bas P. L. , van Berge Henegouwen Mark I. , Biermann Katharina , ten Kate Fiebo J. W. , Busch Olivier R. C. , Dinjens Winand N. M. , Tilanus Hugo W. , van Lanschot J. Jan B. 
Published: September 2010

AbstractBackgroundBoth endoscopic and surgical treatments are recommended for m3‐ or sm1‐adenocarcinomas of the esophagus, depending on patients' lymph nodal status. Lymphatic dissemination is related to tumor infiltration depth, but varying incidences have been reported in m3‐ and sm1‐adenocarcinomas. The study aim was to investigate whether the presence of occult tumor cells in lymph nodes could explain this variation.MethodsSixty‐three node‐negative (N0) patients with early esophageal adenocarcinoma (m2/m3/sm1‐tumors) were included. Multilevel‐sectioning of lymph nodes was performed; sections were stained by means of immunohistochemistry with cytokeratin marker CAM5.2. Two pathologists searched for micrometastases (0.2–2.0 mm) and isolated tumor cells (ITCs, <0.2 mm).ResultsPositive CAM5.2 staining in lymph nodes was not seen in any of the 18 m2‐patients. In 2/25 m3‐tumors (8.0%) an ITC was found, but no micrometastases. Tumor cells were identified in 4/20 sm1‐tumors (20.0%): three micrometastases and one ITC. Median follow‐up was 121 months. Two m3‐patients (3.2%) died due to disease recurrence, including one patient in whom an ITC was detected.ConclusionsLymphatic migration of tumor cells was found in node‐negative m3‐ and sm1‐adenocarcinomas of the esophagus (8.0% and 20.0%, respectively). However, the clinical relevance of these occult tumor cells should become apparent from large series of endoscopically treated patients. J. Surg. Oncol. 2010;102:863–867. © 2010 Wiley‐Liss, Inc.
Prognostic significance of downregulated expression of programmed cell death 5 in chondrosarcoma
Authors: Chen Changbao , Zhou Hua , Xu Lanjun , Liu Xiaoguang , Liu Zhongjun , Ma Dalong , Chen Yingyu , Ma Qingjun 
Published: September 2010

AbstractBackground and ObjectivesProgrammed Cell Death 5 (PDCD5) is a novel apoptosis‐related gene and deregulation of PDCD5 is involved in tumorigenicity. This study was designed to investigate the expression level of PDCD5 and to clarify its clinical significance in chondrosarcoma.MethodsThe mRNA and protein levels of PDCD5 in chondrosarcoma and matched corresponding non‐tumor tissues were evaluated by real‐time PCR and Western blot, respectively. The expression of PDCD5 protein was investigated by immunohistochemistry assays in chondrosarcoma, and its association with clinicopathologic factors and overall survival was also analyzed.ResultsThe mRNA and protein levels of PDCD5 were significantly decreased in chondrosarcoma compared with corresponding non‐tumor tissues. Low expression of PDCD5 protein was 61.8% (21/34) in chondrosarcomas, as compared 12.5% (1/8) in normal bones, as well as compared 23.5% (4/17) in benign cartilage tumors. PDCD5 expression was correlated with anatomical location and histological grade. The survival rate of patients with low‐PDCD5 tumors was lower than that of patients with high‐PDCD5 tumors. Multivariate analysis revealed that the downregulated expression of PDCD5 was an independent prognostic factor for overall survival.ConclusionsPDCD5 is downregulated in chondrosarcoma and might be an independent prognostic factor for overall survival of chondrosarcoma patients. J. Surg. Oncol. 2010;102:838–843. © 2010 Wiley‐Liss, Inc.
Surface Modification of Wood Fiber and Preparation of a Wood Fiber–Polypropylene Hybrid by In situ Polymerization
Authors: Reddy C. Ravindra , Simon Leonardo C. 
Published: September 2010

AbstractThe surface functionalization of wood fiber was performed by chemical modification with bi‐functional organo‐silane 7‐octenyldimethylchlorosilane (7‐ODMCS) and mono‐functional organo‐silane n‐octyldimethylchlorosilane (n‐ODMCS). The chloro functionality of organo‐silane modifiers was utilized to functionalize wood fiber. The resulting modified fiber was characterized for thermal stability (thermal gravimetric analysis), presence of organic groups on the surface (Fourier‐transform IR), for particle size (microscopy) and for its hydrophobicity by dispersing in toluene. The modified fiber was used for in situ polymerization of propylene to obtain a wood fiber–polypropylene hybrid. The terminal olefin functionality of 7‐ODMCS was utilized for co‐polymerization of propylene during in situ polymerization. The wood fiber–polypropylene hybrid samples were characterized for thermal analysis. In order to confirm the co‐polymerization of propylene in 7‐ODMCS modified fiber during in situ polymerization, n‐ODMCS modified fiber having no olefin functionality was also used in in situ polymerization. magnified image
Reference region‐based pharmacokinetic modeling in quantitative dynamic contract‐enhanced MRI allows robust treatment monitoring in a rat liver tumor model despite cardiovascular changes
Authors: Steingoetter Andreas , Svensson Jonas , Kosanke Yvonne , Botnar Rene M. , Schwaiger Markus , Rummeny Ernst , Braren Rickmer 
Published: September 2010

AbstractIn this work, two pharmacokinetic modeling techniques, population arterial input function model, and reference region model, were applied to dynamic contract‐enhanced MRI data, to test the influence of a change in heart rate on modeling parameters. A rat population arterial input function was generated by dynamic contrast‐enhanced computed tomography measurements using the MR contrast agent gadolinium diethylenetriamine penta‐acetic acid. Then, dynamic contract‐enhanced MRI was used for treatment monitoring in two groups of hepatocellular carcinoma bearing rats. Whereas group 1 had the same heart rate as animals analyzed for the population arterial input function (263 ± 20 bpm), group 2 had a higher heart rate (369 ± 11 bpm) due to a different anesthesia protocol. The pharmacokinetic modeling parameters volume transfer constantKtransand relative extravascular extracellular spacevewere calculated with both models and statistically compared. For group 1, good correlation and agreement was found between the models showing no difference inKtransandve(ΔKtrans: 4 ± 19% and Δve: 4 ± 12%,P= 0.2). In contrast, for group 2, a bias in parameter values for the population arterial input function model was detected (ΔKtrans: −45 ± 7% and Δve: −31 ± 7%,P≤ 0.001). The presented work underlines the value of the reference region model in longitudinal treatment monitoring and provides a straightforward approach for the generation of a rat population arterial input function. Magn Reson Med, 2010. © 2010 Wiley‐Liss, Inc.
Indirectly probing Ca2+ handling alterations following myocardial infarction in a murine model using T1‐mapping manganese‐enhanced magnetic resonance imaging
Authors: Waghorn Benjamin , Schumacher Autumn , Liu Jimei , Jacobs Stephanie , Baba Akemichi , Matsuda Toshio , Yanasak Nathan , Hu Tom C.‐C. 
Published: September 2010

AbstractProlonged ischemia causes cellular necrosis and myocardial infarction (MI) via intracellular calcium (Ca2+) overload. Manganese‐enhanced MRI indirectly assesses Ca2+ influx movement in vivo as manganese (Mn2+) is a Ca2+ analog. To characterize myocardial Mn2+ efflux properties, T1‐mapping manganese‐enhanced MRI studies were performed on adult male C57Bl/6 mice in which Ca2+ efflux was altered using pharmacological intervention agents or MI‐inducing surgery. Results showed that (1) Mn2+ efflux rate increased exponentially with increasing Mn2+ doses; (2) SEA0400 (a sodium–calcium exchanger inhibitor) decreased the rate of Mn2+ efflux; and (3) dobutamine (a positive inotropic agent) increased the Mn2+ efflux rate. A novel analysis technique also delineated regional features in the MI mice, which showed an increased Mn2+ efflux rate in the necrosed and peri‐infarcted tissue zones. The T1‐mapping manganese‐enhanced MRI technique characterized alterations in myocardial Mn2+ efflux rates following both pharmacologic intervention and an acute MI. The Mn2+ efflux results were consistent with those in ex vivo studies showing an increased Ca2+ concentration under similar conditions. Thus, T1‐mapping manganese‐enhanced MRI has the potential to indirectly identify and quantify intracellular Ca2+ handling in the peri‐infarcted tissue zones, which may reveal salvageable tissue in the post‐MI myocardium. Magn Reson Med, 2010. © 2010 Wiley‐Liss, Inc.
Rapid six‐degree‐of‐freedom motion detection using prerotated baseline spherical navigator echoes
Authors: Liu Junmin , Drangova Maria 
Published: September 2010

AbstractA new spherical navigator echo (SNAV) registration technique is presented. This technique starts by collecting a set of SNAV templates at a reference position. These templates are acquired by rotating the gradient system to result in rotation angles that uniformly cover a predefined range of rotation. The rotation angles between an unknown physically transformed position and the reference position are subsequently determined by finding the template with the lowest sum of squared differences with SNAV at the transformed position. Translations are calculated from the phase differences between the best‐match SNAV template and the SNAV acquired at the transformed position. In comparison with the conventional SNAV registration technique, the proposed technique is noniterative, robust, and can detect 3‐dimensional rigid body motion in less than 50 msec. The technique was verified with phantom and in vivo experiments, which demonstrated subdegree rotational and submillimeter translational accuracy over a range of simultaneous ±20° and ±10° mm of motion. Magn Reson Med, 2011. © 2010 Wiley‐Liss, Inc.
Attitudes toward sex selection: a survey among potential users in Israel
Authors: Hashiloni‐Dolev Yael , Hirsh‐Yechzkel Galit , Boyko Valentina , Wainstock Tamar , Schiff Eyal , Lerner‐Geva Liat 
Published: September 2010

AbstractObjectiveSince 1995, Israel allows social sex selection (SxS) under certain circumstances. However, data regarding the attitudes of potential users are limited.MethodsThe study population composed of a stratified sample of Israeli married men and women at the reproductive age (women aged 17–45, men aged 17–65), who had 1–2, 3, or 4+ children of the same sex.We conducted telephonic interviews with 687 Israeli residents using a structured questionnaire that included the following items: demographic characteristics, opinions regarding SxS, personal interest in expanding the family, and interest in choosing the sex of a future child.ResultsAmong the group of respondents who wanted to have more children (true potential users of the technology), 42.6% wished to select the sex of a future child. Strong desire for family balancing was found. In a multivariable logistic regression model, being an ultra‐orthodox was associated with a lower desire to choose (OR = 0.02; 95% CI: 0.01–0.06), while having more same‐sex children was associated with a greater desire to choose (OR = 3.12; 95% CI: 1.54–6.32).ConclusionsIt can be estimated that if SxS were to be freely permitted in Israel, less than half of those for whom SxS is truly relevant would want to use the technology. Copyright © 2010 John Wiley & Sons, Ltd.
Maternal serum insulin‐like growth factor‐I at 11–13 weeks in preeclampsia
Authors: Sifakis Stavros , Akolekar Ranjit , Kappou Dimitra , Mantas Nikitas , Nicolaides Kypros H. 
Published: September 2010

AbstractObjectiveTo investigate the maternal serum concentration of insulin‐like growth factor‐I (IGF‐I) in the first trimester of pregnancies that subsequently develop preeclampsia (PE) and to examine the possible association with uterine artery pulsatility index (PI).MethodsThe maternal serum concentration of IGF‐I and uterine artery PI at 11–13 weeks were measured in 53 cases that developed PE, including 18 that required delivery before 34 weeks (early‐PE) and 106 unaffected controls. The measured IGF‐I concentration and uterine artery PI were converted into a multiple of the expected median (MoM) in unaffected pregnancies, and median MoM values were compared in the outcome groups. The significance of association of IGF‐I MoM with uterine artery PI MoM was determined by regression analysis.ResultsIn the early‐PE and late‐PE groups, compared to the unaffected controls, the median IGF‐I decreased (0.53 and 0.55 MoM, respectively) and uterine artery PI increased (1.55 and 1.21 MoM, respectively). In the group that developed PE, there was no significant association between serum IGF‐I and uterine artery PI (p = 0.632).ConclusionIn pregnancies destined to develop PE, the circulating levels of IGF‐I decrease from the first trimester of pregnancy suggesting that IGF‐I may be implicated in the pathogenesis of the disease. Copyright © 2010 John Wiley & Sons, Ltd.
Compact spectrum splitting photovoltaic module with high efficiency
Authors: McCambridge James D. , Steiner Myles A. , Unger Blair L. , Emery Keith A. , Christensen Eric L. , Wanlass Mark W. , Gray Allen L. , Takacs Laszlo , Buelow Roger , McCollum Timothy A. , Ashmead James W. , Schmidt Greg R. , Haas Alex W. , Wilcox John R. , Van Meter James , Gray Jeffery L. , Moore Duncan T. , Barnett Allen M. , Schwartz Richard J. 
Published: September 2010

AbstractWe have designed, fabricated, and tested a small, integrated photovoltaic module comprised of two separately‐contacted, high efficiency, multijunction solar cells and non‐imaging optics that both concentrate and spectrally split the incoming light. This hybrid design allows us to individually optimize the tandem cells and optical elements. The system has a measured module efficiency, including optical and packaging losses but not power combination losses, of 38.5 ± 1.9% under the AM1.5 direct terrestrial spectrum. The internal optics concentrate the light by a factor of approximately 20. We find excellent agreement between the modeled and measured performance. This is the highest confirmed conversion efficiency demonstrated for a photovoltaic module. Copyright © 2010 John Wiley & Sons, Ltd.
Thermal and pH‐sensitive gold nanoparticles from H‐shaped block copolymers of (PNIPAM/PDMAEMA)‐b‐PEG‐b‐(PNIPAM/PDMAEMA)
Authors: Li Li‐Ying , He Wei‐Dong , Li Wen‐Tao , Zhang Ke‐Ren , Pan Ting‐Ting , Ding Zong‐Lei , Zhang Bo‐Yu 
Published: September 2010

AbstractWell‐defined H‐shaped pentablock copolymers composed of poly(N‐isopropylacrylamide) (PNIPAM), poly(N,N‐dimethylaminoethylacrylamide) (PDMAEMA), and poly(ethylene glycol) (PEG) with the chain architecture of (A/B)‐b‐C‐b‐(A/B) were synthesized by the combination of single‐electron‐transfer living radical polymerization, atom‐transfer radical polymerization, and click chemistry. Single‐electron‐transfer living radical polymerization of NIPAM using α,ω azide‐capped PEG macroinitiator resulted in PNIPAM‐b‐PEG‐b‐PNIPAM with azide groups at the block joints. Atom‐transfer radical polymerization of DMAEMA initiated by propargyl 2‐chloropropionate gave out α‐capped alkyne‐PDMAEMA. The H‐shaped copolymers were finally obtained by the click reaction between PNIPAM‐b‐PEG‐b‐PNIPAM and alkyne‐PDMAEMA. These copolymers were used to prepare stable colloidal gold nanoparticles (GNPs) in aqueous solution without any external reducing agent. The formation of GNPs was affected by the length of PDMAEMA block, the feed ratio of the copolymer to HAuCl4, and the pH value. The surface plasmon absorbance of these obtained GNPs also exhibited pH and thermal dependence because of the existence of PNIAPM and PDAMEMA blocks. © 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2010
Preparation of miktoarm star‐block copolymers PSn‐b‐PVAc4‐n via combination of ATRP and RAFT polymerization
Authors: Qiu Yansheng , Zhang Wei , Yan Yuefang , Zhu Jian , Zhang Zhengbiao , Zhu Xiulin 
Published: September 2010

AbstractThree tetrafunctional bromoxanthate agents (Xanthate3‐Br, Xanthate2‐Br2, and Xanthate‐Br3) were synthesized. Initiative atom transfer radical polymerizations (ATRP) of styrene (St) or reversible addition fragmentation chain transfer (RAFT) polymerizations of vinyl acetate (VAc) proceeded in a controlled manner in the presence of Xanthate3‐Br, Xanthate2‐Br2, or Xanthate‐Br3, respectively. The miktoarm star‐block copolymers containing polystyrene (PS) and poly(vinyl acetate) (PVAc) chains, PSn‐b‐PVAc4‐n (n = 1, 2, and 3), with controlled structures were successfully prepared by successive RAFT and ATRP chain‐extension experiments using VAc and St as the second monomers, respectively. The architecture of the miktoarm star‐block copolymers PSn‐b‐PVAc4‐n (n = 1, 2, and 3) were characterized by gel permeation chromatography and 1H NMR spectra. Furthermore, the results of the cleavage of PS3‐b‐PVAc and PVAc2‐b‐PS2 confirmed the structures of the obtained miktoarm star‐block copolymers. © 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2010
Synthesis of the raspberry‐like PS/PAN particles with anisotropic properties via seeded emulsion polymerization initiated by γ‐ray radiation
Authors: Huang Haofeng , Liu Huarong 
Published: September 2010

AbstractWe herein report a facile method to prepare the submicron‐sized raspberry‐like polystyrene/polyacrylonitrile particles with anisotropic properties and controllable structure via γ‐radiation‐induced seeded emulsion polymerization under ambient pressure and at room temperature, in which the monodisperse crosslinked styrene‐divinylbenzene‐acrylic acid terpolymer (P(S‐DVB‐AA)) particles were used as seed particles and acrylonitrile (AN) as the second monomer. The influence of the weight ratio of polymer/monomer, the absorbed dose rate, the absorbed dose, and the dispersion medium on the morphology of the as‐prepared particles was investigated. The final products were thoroughly characterized by Fourier transform infrared spectroscopy (FTIR), field‐emission scanning electron microscopy, and transmission electron microscopy. The results showed that the raspberry‐like particles could be fabricated in high yield. © 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2010