bluuebunny/crossref_metadata_2025_split huggingface dataset:
Post hocpower estimation in large-scale multiple testing problems
Authors: Zehetmayer Sonja , Posch Martin 
Published: February 2010

AbstractBackground: The statistical power or multiple Type II error rate in large-scale multiple testing problems as, for example, in gene expression microarray experiments, depends on typically unknown parameters and is therefore difficult to assess a priori. However, it has been suggested to estimate the multiple Type II error rate post hoc, based on the observed data.Methods: We consider a class of post hoc estimators that are functions of the estimated proportion of true null hypotheses among all hypotheses. Numerous estimators for this proportion have been proposed and we investigate the statistical properties of the derived multiple Type II error rate estimators in an extensive simulation study.Results: The performance of the estimators in terms of the mean squared error depends sensitively on the distributional scenario. Estimators based on empirical distributions of the null hypotheses are superior in the presence of strongly correlated test statistics.Availability: R-code to compute all considered estimators based on P-values and supplementary material is available on the authors web page http://statistics.msi.meduniwien.ac.at/index.php?page=pageszfnrContact: martin.posch@meduniwien.ac.atSupplementary information: Supplementary data are available at Bioinformatics online.
High quality SNP calling using Illumina data at shallow coverage
Authors: Malhis Nawar , Jones Steven J. M. 
Published: February 2010

Abstract
Motivation: Detection of single nucleotide polymorphisms (SNPs) has been a major application in processing second generation sequencing (SGS) data. In principle, SNPs are called on single base differences between a reference genome and a sequence generated from SGS short reads of a sample genome. However, this exercise is far from trivial; several parameters related to sequencing quality, and/or reference genome properties, play essential effect on the accuracy of called SNPs especially at shallow coverage data. In this work, we present Slider II, an alignment and SNP calling approach that demonstrates improved algorithmic approaches enabling larger number of called SNPs with lower false positive rate. In addition to the regular alignment and SNP calling, as an optional feature, Slider II is capable of utilizing information about known SNPs of a target genome, as priors, in the alignment and SNPs calling to enhance it's capability of detecting these known SNPs and novel SNPs and mutations in their vicinity.
Contact: nmalhis@bcgsc.ca
Supplementary information and availability: Supplementary data are available at Bioinformatics online and at http://www.bcgsc.ca/platform/bioinfo/software/SliderII
Prolonged Remission of a Demyelinating Neuropathy in a Patient With Lymphoma and Sjögren's Syndrome After Rituximab Therapy
Authors: Botez Stephan A , Herrmann David N 
Published: February 2010

ABSTRACT

Chronic acquired demyelinating polyneuropathies may be refractory to conventional therapy including corticosteroids, plasma exchange, and intravenous immunoglobulin (Ig) or require long-term immunotherapy to maintain remission. Use of alternative approaches such as Rituximab, an anti-CD20 antibody, in the treatment of demyelinating polyneuropathy, unrelated to IgM gammopathy and myelin-associated glycoprotein antibodies, has been the subject of only a few case reports. We report the case of a 79-year-old woman with a distal acquired demyelinating polyneuropathy in the context of Sjögren's syndrome, IgG paraproteinemia, and occult lymphoma who has had an excellent and durable response to Rituximab therapy.
Muscle-Eye-Brain Disease
Authors: Shenoy Anant M , Markowitz Jennifer A , Bonnemann Carsten G , Krishnamoorthy Kalpathy , Bossler Aaron D , Tseng Brian S 
Published: February 2010

ABSTRACT

A term female infant was evaluated for global developmental delay, hypotonia, hyporeflexia, diffuse weakness including facial muscles, and visual impairment with optic nerve hypoplasia. In the absence of family history or perinatal concerns, an extensive investigation was performed, including lab studies, muscle biopsy, brain MRI and focused genetic testing. This revealed elevated serum CK, a structurally abnormal brain, and a dystrophic-appearing muscle biopsy with evidence of a glycosylation defect in the alpha-dystroglycan complex. Of the 6 known related genes, testing of the POMGnT1 gene showed three heterozygous missense mutations. Thus her history, examination, biopsy specimen, imaging, laboratory, and genetic studies are all consistent with the diagnosis of Muscle-Eye-Brain (MEB) disease. MEB is one of an emerging spectrum of congenital disorders that involve both central and peripheral nervous systems, described further in this case report.
Contralateral Cranial Polyneuropathy Due to Perineural Invasion by a Cutaneous Squamous Cell Carcinoma
Authors: Sundaram Arun N E , Simmons Zachary , Towfighi Javad , Sheehan Jonas , Reichwein Raymond 
Published: February 2010

ABSTRACT

Cutaneous malignancies may spread to underlying nerves, a process known as perineural invasion (PNI). We report a patient who was found to have PNI presenting as a cranial polyneuropathy on the contralateral side of the face many years after the resection of a squamous cell carcinoma. All diagnostic testing was unrevealing until nerve biopsy was performed. This emphasizes the long asymptomatic period between treatment of a cutaneous malignancy and detection of PNI, and the development of PNI at a site distant from the original malignancy. Biopsy of a clinically involved nerve may permit diagnosis of PNI when other studies are normal.
Sensory Neuronopathy With Ro Antibodies: Response to Combination Immunosuppression
Authors: Hussain Aamir , Scelsa Stephen N 
Published: February 2010

ABSTRACT

The objective of this study was to describe a case of sensory neuronopathy syndrome (SNS) with Ro antibodies who had nearly complete functional recovery with combination immunosuppression. Plasma exchange, azathioprine, and hydroxychloroquine were used in combination. The gait ataxia, kinesthetic sensation, and sensory response amplitudes showed considerable recovery with excellent functional outcomes. Prompt combined therapy with azathioprine and hydroxychloroquine is a promising therapy for patients with sensory neuronopathy syndrome and Ro antibodies.
Arabidopsis RNA-Dependent RNA Polymerases and Dicer-Like Proteins in Antiviral Defense and Small Interfering RNA Biogenesis during Turnip Mosaic Virus Infection
Authors: Garcia-Ruiz Hernan , Takeda Atsushi , Chapman Elisabeth J. , Sullivan Christopher M. , Fahlgren Noah , Brempelis Katherine J. , Carrington James C. 
Published: February 2010

Abstract
Plants respond to virus infections by activation of RNA-based silencing, which limits infection at both the single-cell and system levels. Viruses encode RNA silencing suppressor proteins that interfere with this response. Wild-type Arabidopsis thaliana is immune to silencing suppressor (HC-Pro)-deficient Turnip mosaic virus, but immunity was lost in the absence of DICER-LIKE proteins DCL4 and DCL2. Systematic analysis of susceptibility and small RNA formation in Arabidopsis mutants lacking combinations of RNA-dependent RNA polymerase (RDR) and DCL proteins revealed that the vast majority of virus-derived small interfering RNAs (siRNAs) were dependent on DCL4 and RDR1, although full antiviral defense also required DCL2 and RDR6. Among the DCLs, DCL4 was sufficient for antiviral silencing in inoculated leaves, but DCL2 and DCL4 were both involved in silencing in systemic tissues (inflorescences). Basal levels of antiviral RNA silencing and siRNA biogenesis were detected in mutants lacking RDR1, RDR2, and RDR6, indicating an alternate route to form double-stranded RNA that does not depend on the three previously characterized RDR proteins.
The augmented subjective risk management process
Authors: Emblemsvåg Jan 
Published: February 2010

PurposeThis paper aims to present an augmented subjective risk management process that can partially solve the problem of inconsistent results in qualitative risk management. Note that “subjective” in this context is to separate this risk management process from the purely statistical risk management processes often associated with finance.Design/methodology/approachThe approach has been developed by logically approaching the problem of inconsistency and, based on experience and literature review, conceptually designing a solution.FindingsThe presented approach seems workable and indeed an improvement over standard qualitative approaches given reasonable skillful implementation.Research limitations/implicationsThe approach has not yet been tested in real life, which must be undertaken in the future.Practical implicationsThe presented approach will expand the subjective risk management process to include information management and to some extent knowledge management and thus add some more activities to the practice of risk management.Originality/valueThe paper presents an approach that so far seems useful in improving the consistency of subjective risk management. Also, it may be a valuable point of departure for further research.
Corporate environmental and financial performance: a multivariate approach
Authors: Moneva José M. , Ortas Eduardo 
Published: February 2010

PurposeThe aim of this paper is to evaluate the significance of the link between corporate environmental and financial performance in order to show managers how an adequate management of environmental factors could contribute to the financial success of the firm.Design/methodology/approachThe paper analyses the environmental and financial performance of a sample of 230 European companies. Under the stakeholder approach, the commitment to environmental performance is analysed and linked with the firms' financial improvement. The paper proposes a partial least squares model (PLS) for measuring corporate environmental and financial performance that seems to be the first time which has been applied in the field.FindingsThe results support the idea that enterprises which obtained higher rates of environmental performance show better financial performance levels in the future.Research limitations/implicationsThe lack of a long series of environmental performance data for organisations is an obstacle for a broader analysis. This research shows the usefulness of the multivariate modelling for analysing the environmental and financial performance of businesses.Practical implicationsIn practice, this research may show managers the need of taking into account the environmental management factors when configuring the strategic policy of the firm and how environmental management can impact to the financial success of the firms.Originality/valueThe use of PLS modelling for measuring environmental and financial performance theoretical concepts and considering a sample of European companies for the empirical analysis.
Protection for profiting from collaborative service innovation
Authors: Hurmelinna‐Laukkanen Pia , Ritala Paavo 
Published: February 2010

PurposeProfiting from service innovations can be challenging. It is not only a question of pricing and marketing the services appropriately, but also of keeping competitors from imitating them. The purpose of this paper is to discuss how service innovation differs from technology/product innovation in terms of protection, and how this shows in collaborative innovation activities.Design/methodology/approachThe paper offers a literature review combining discussion related to service research and strategic management. Empirical evidence is provided in the form of a multifaceted case study illustrating some of the aspects of collaborative service innovation.FindingsThe results indicate that characteristics separating service innovations from product or process innovations influence the efficacy of protection. This, in turn, may make or break the subsequent value appropriation. Furthermore, as service innovation typically includes collaborative activities, there is another twist to protection: companies must protect knowledge that brings them competitive advantage, but on the other hand they need to foster knowledge sharing, which may be in conflict with protective measures. As a result, service innovators cannot rely solely on intellectual property right strategies, as their counterparts working with products might do, but the service element requires taking a wider look around, and utilizing means such as human resource management, lead time, and contracting.Originality/valueThe novelty of this paper lies in its analysis of two very recent trends: collaboration (and coopetition) in innovation, and the tendency to introduce business models that bring service innovations to the core of the offering. Augmenting prior knowledge, the paper brings forth issues that need to be acknowledged when service innovations are created, protected, and appropriated.
Lack of preferential treatment: effects on dissatisfaction after a service failure
Authors: Varela‐Neira Concepción , Vázquez‐Casielles Rodolfo , Iglesias Víctor 
Published: February 2010

PurposePreferential treatment of selected customers is one of the strategies employed by companies seeking to implement relationship marketing. However, it remains unclear whether or not this policy negatively affects relationships with customers not receiving the above‐mentioned preferential treatment, as existing literature focuses, for the most part, on the beneficiaries. The purpose of this paper is to study whether or not the perception of lack of preferential treatment has a positive impact on dissatisfaction following a service failure, after accounting for the effects of attribution.Design/methodology/approachThe sample used in this paper consists of 344 subjects who, over the last six months, have experienced service failures. The data are collected via personal interviews using a structured survey. Structural equation modelling is employed in order to test the relationship between lack of preferential treatment and dissatisfaction.FindingsThe results of this investigation indicate that lack of preferential treatment has an additional explanatory power with regard to customer dissatisfaction, after considering the effects of attributions, and that negative emotions have a mediation effect on the relationship between these cognitive antecedents and the aforementioned dissatisfaction.Research limitations/implicationsThis paper examines only one service context; as a consequence, caution is needed when generalizing the results.Practical implicationsGiven the findings of this paper, managers are advised to consider the “merits” of preferential treatment to help strengthen customer relationships.Originality/valueThis paper provides an initial step towards understanding the impact of systematic and deliberate use of preferential treatment as a relationship marketing strategy from a non‐beneficiaries perspective.
A comparative study of mobile messaging services acceptance to participate in television programmes
Authors: Ruiz Mafé Carla , Sanz Blas Silvia , Fernando Tavera‐Mesías Juan 
Published: February 2010

PurposeThe purpose of this paper is to analyse key drivers of consumer acceptance of short messaging services (SMS) to participate in TV programmes.Design/methodology/approachThe technology acceptance model (TAM) and the theory of planned behaviour (TPB) have been integrated for the determinants of the acceptance of mobile data services incorporating variables regarding consumer‐media interaction (perceived value and affinity). The model has been tested using structural equation modelling.FindingsPerceived value, attitude and affinity towards television (TV) programmes determine SMS acceptance to participate in TV programmes in Spain. In contrast, subjective norm, perceived value and attitude are the key drivers of SMS acceptance in Colombia.Practical implicationsThis paper enables mobile companies and TV channels to know what aspects to improve in order to promote SMS‐based TV programmes. Marketers should highlight in their communication strategies user friendliness, usefulness and perceived value of mobile data services. In Colombia, programme stars and presenters should encourage the use of mobile services to interact with TV. Spanish companies should offer reliable and entertaining programme contents to improve consumers' affinity.Originality/valueAlthough TAM and TPB have successfully explained behavioural intentions, previous research posits that they should be extended to properly explain mobile services acceptance. This paper combines the influence of perceived value, affinity and the TAM and TPB models to develop an improved model for SMS acceptance. The study also integrates variables for two communication media (TV and mobile) and compares SMS acceptance to participate in TV programmes in two markets with different culture and mobile services penetration rates.
Exploring the interrelationship among patterns of service strategy changes and organizational design elements
Authors: Gebauer Heiko , Fischer Thomas , Fleisch Elgar 
Published: February 2010

PurposeThe purpose of this paper is to explore the patterns of service strategy changes in manufacturing firms and indicates how each pattern is interrelated with modifications in organizational design elements.Design/methodology/approachThe paper draws on a longitudinal study using a survey of 97 manufacturers of capital goods. In addition, 15 case studies have been conducted. Survey and qualitative data are obtained in 1997, 2001, and 2004.FindingsThe findings highlight four patterns of service strategy changes: from customer service strategy to after‐sales service provider, from after‐sales service provider to customer‐support service provider, from customer‐support service provider to development partner, and from customer‐support service provider to the outsourcing partner. Evidence of specific alignment between service strategy and organizational design elements is provided.Research limitations/implicationsThe main limitation of this paper is the purposive sample.Practical implicationsManagers should follow the patterns of service strategy changes by extending the service offerings and modifying the organizational design elements.Originality/valuePrevious studies investigate service strategies and organizational design elements only at a specific time, which leads to a static perspective. This paper offers insights into interrelations among service strategy changes and organizational design elements.
A conceptual framework of hotel experience and customer‐based brand equity
Authors: Bill Xu Jing , Chan Andrew 
Published: February 2010

PurposeThere is increasing discussion of the way in which quality of experience and brand equity are developed in the hotel industry. This study aims to review the hospitality and brand equity literature, thereby providing a conceptual framework for understanding hotel brand equity.Design/methodology/approachA comprehensive and extensive literature review helps develop a brand equity framework for the hotel industry.FindingsHotels often use advertising, referral marketing and services marketing to help guests acquire brand‐related information. Hotel guests, in turn, establish their brand knowledge through direct and indirect experiences. A better understanding of how these experiences contribute to brand equity has important implications for brand managers. Advertising and word of mouth (WoM) can be used to generate brand awareness and brand associations. Service performance should be nurtured to predominantly precipitate quality of experience, although WoM also has a strong effect on it.Originality/valueThe study attempts to fill the gaps in the discussion of the way in which hotel brand equity is developed. A research framework embedded with quality of experience is proposed. Critical research questions about hotel experience and brand equity are identified.
Productivity, exchange rates, and competitive advantage
Authors: Schnabel Jacques A. 
Published: February 2010

PurposeThe purpose of this paper is to contextualize a productivity contest between a local manufacturer versus a foreign one, both of whom sell an identical product in the local market, within the two companies' respective economies. The intent is to delineate the conditions under which one firm gains a competitive advantage over the other.Design/methodology/approachThe purchasing power parity model is reformulated to account for differential rates of macroeconomic productivity gain in the two countries. The implications of these differential rates vis‐à‐vis the productivity contest between the local and foreign manufacturer are then explored.FindingsTo gain a competitive advantage over its foreign rival, the local firm must achieve a net productivity improvement relative to its (local) economy that surpasses the net productivity improvement of the foreign rival relative to its (foreign) economy. Thus, the local firm stands in a rivalrous relationship not solely with its foreign competitor but also with the average firm in its very own (local) economy and in a complementary relationship with the average firm in the foreign economy. The foregoing is shown to be a generalization of the Dutch disease phenomenon and to imply that national efforts to attain competitive advantage are self‐contradictory.Practical implicationsIn its productivity contest with its foreign rival, the local firm's management should not focus myopically on a comparison of the two firms' rates of net productivity improvement. Rather, the focus should be on the two firms' differential rates of net productivity improvement relative to their respective economies.Originality/valueThe main conclusions of this paper, which derive from the effect of productivity changes on exchange rates, are both stark and original. A firm is engaged in a productivity contest with the average firm in its own economy. Thus, national efforts to enhance productivity are counter productive to a firm whose productivity improvement lags behind that of the average domestic firm.
Capital budgeting practices in the Jordanian industrial corporations
Authors: Khamees Basheer Ahmad , Al‐Fayoumi Nedal , Al‐Thuneibat Ali A. 
Published: February 2010

PurposeThe purpose of this paper is to provide additional empirical evidence about capital budgeting practices in an emerging economy.Design/methodology/approachThe study utilizes a questionnaire and interview to collect data from respondents.FindingsThe results show that the JIC give almost equal importance to the discounted and undiscounted cash flow methods in evaluating capital investment projects. It appeared also that the most frequent used technique is the profitability index followed by the payback period.Practical implicationsBased on these results, the researchers recommend putting a great attention to apply the concepts and techniques of capital budgeting in an appropriate manner. The corporations should also consider importance of information technology and its applications in capital budgeting.Originality/valueThis is the first study applied on the capital budgeting practices and its related issues in the JIC.