bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recurrent laryngeal nerve monitoring versus identification alone on post‐thyroidectomy true vocal fold palsy: A meta‐analysis
Authors: Higgins Thomas S. , Gupta Reena , Ketcham Amy S. , Sataloff Robert T. , Wadsworth J. Trad , Sinacori John T. 
Published: March 2011

AbstractObjectives/Hypothesis:To compare by meta‐analysis the effect of recurrent laryngeal nerve (RLN) monitoring versus RLN identification alone on true vocal fold palsy rates after thyroidectomy.Study Design:Systematic review and meta‐analysis.Methods:A search of MEDLINE (1966–July 2008), EMBASE (1980–July 2008), Cochrane Central Register of Clinical Trials (CENTRAL), Cochrane Database of Systematic Reviews, clinicaltrials.gov, and The National Guideline Clearinghouse databases was performed. References from retrieved articles, presentation data, and correspondence with experts was also included. All authors used a detailed list of inclusion/exclusion criteria to determine articles eligible for final inclusion. Two authors independently extracted data including study criteria, methods of vocal fold function assessment, laryngeal nerve monitor type, and surgical procedure. Odds ratios (OR) were pooled using a random‐effects model. Associations with patient and operative characteristics were tested in subgroups.Results:One randomized clinical trial, seven comparative trials, and 34 case series evaluating 64,699 nerves‐at‐risk were included. The overall incidence of true vocal fold palsy (TVFP) was 3.52% for intraoperative nerve monitoring (IONM) versus 3.12% for nerve identification alone (ID) (OR 0.93; 95% confidence interval [CI], 0.76‐1.12]. No statistically significant difference in transient TVFP (2.74% IONM vs. 2.49% ID [OR 1.07, 95% CI, 0.95‐1.20]), persistent TVFP (0.75% IONM vs. 0.58% ID [OR 0.99, 95% CI, 0.79‐1.23]), or unintentional RLN injury (0.12% IONM vs. 0.33% ID [OR 0.50, 95% CI, 0.15‐1.75]) was found.Conclusions:This meta‐analysis demonstrates no statistically significant difference in the rate of true vocal fold palsy after using intraoperative neuromonitoring versus recurrent laryngeal nerve identification alone during thyroidectomy.
A CASE ASSESSMENT OF THE MECHANISMS INVOLVED IN HUMAN‐INDUCED LAND DEGRADATION IN NORTHEASTERN KUWAIT
Authors: AL‐Awadhi J. M. 
Published: March 2011

ABSTRACTSoil degradation and vegetation deterioration in contrasting areas (open desert versus protected desert) in the northeastern part of Kuwait were investigated, using field measurements, and laboratory methodologies. The average infiltration rate of compacted soils studied was found to be 52 per cent lower than that of the undisturbed soils we investigated. The bulk density of the compacted soils was 19 per cent higher than that of the non‐compacted soils. The average topsoil resistance of severely compacted soils was 13 per cent greater than that of undisturbed soils and is mainly due to overgrazing, and off‐road vehicle use. We found that the overall vegetation cover status of open areas investigated was approximately 70 per cent less than for the protected areas studied. As a consequence of soil compaction and vegetation deterioration, sand deflation processes, and sand movement prevail in open areas. The total average percentages of course grain sizes in unprotected soils and heavily disturbed soils by vehicles (off‐road) are 51 and 103 per cent greater, respectively. The annual rate of sand transport during the last 20 years, from the prevailing wind direction (NW) in the area has increased by 81 per cent. The delicate balance between soil and natural vegetation cover is easily disturbed by off‐road vehicle use associated with overgrazing and recreation activity. A restoration plan is needed in order to reduce land degradation and to allow natural vegetation recovery. Copyright © 2011 John Wiley & Sons, Ltd.
Anarchy of effects? Exploring attention to online advertising and multiple outcomes
Authors: Goodrich Kendall 
Published: March 2011

AbstractThis research examines the relationship between attention to online advertising and brand attitude, aided recall, and purchase intention. Results indicate that attention to an ad is affected by ad type (pictorial vs. text) and the interaction between ad location (left vs. right) and page (image‐oriented vs. textual), suggesting a range of factors that impact attention. Furthermore, under the online conditions of this study, attention is positively related to aided recall and to purchase intention, but negatively associated with brand attitude. Re‐sults are interpreted in the framework of dual attitude theory (Wilson, Lindsey, & Schooler, 2000) and other effects models. Although a clear “hierarchy of effects” appears to be elusive, the results suggest that marketers must fully evaluate advertising goals prior to creative development. © 2011 Wiley Periodicals, Inc.
H. pylori cagL amino acid sequence polymorphism Y58E59 induces a corpus shift of gastric integrin α5β1 related with gastric carcinogenesis
Authors: Yeh Yi‐Chun , Chang Wei‐Lun , Yang Hsiao‐Bai , Cheng Hsiu‐Chi , Wu Jiunn‐Jung , Sheu Bor‐Shyang 
Published: March 2011

AbstractWe tested whether cagL amino acid sequence polymorphisms of Helicobacter pylori correlated to clinico‐histological outcomes and gastric α5β1 integrin expressions. One hundred forty five patients with H. pylori infection and 47 noninfected controls were enrolled to check gastric integrin α5β1 intensities topographically. The collected isolates were screened for cagL‐genotype by polymerase chain reaction (PCR), and assessed for amino acid sequence polymorphisms using sequence translation. Our H. pylori isolates were predominantly (98.6%) cagL‐genopositive, 95.8% of which had the RGD motif in their amino acid sequences. The isolates from the gastric cancer (GCA) patients indicated a higher rate of amino acid sequence polymorphisms—Y58 and E59—than those of the non‐GCA patients (P < 0.05). The polymorphisms as Y58E59 noted with increased risk of GCA up to 4.6‐fold (95%CI: 1.8–11.9). H. pylori‐infected patients had higher integrin α5β1 than noninfected patients (P < 0.05). Furthermore, cagL‐Y58E59 H. pylori infection predisposed an upward shift in integrin α5β1 (P = 0.007) in the corpus, leading to more severe corpus chronic inflammation (P < 0.05). H. pylori CagL amino acid polymorphisms like Y58E59 correlate with a higher risk of GCA, and may regulate a corpus shift of gastric integrin α5β1 to lead to severe corpus gastritis during gastric carcinogenesis. Mol. Carcinog. © 2011 Wiley‐Liss, Inc.
Can spiral analysis predict the FP‐CIT SPECT scan result in tremulous patients?
Authors: Bajaj Nin P.S. , Knöbel Maria , Gontu Vamsi , Bain Peter G. 
Published: March 2011

AbstractBackground:Previous studies have compared the accuracy of spiral analysis in distinguishing essential tremor (ET) from PD. In this study, we have used this technique to distinguish cases of tremulous PD (TDPD) (N = 24) from tremulous parkinsonian subjects without evidence of dopaminergic deficit (N = 41).Methods:All patients were characterized on clinical and 123I‐N‐ω‐fluoro‐propyl‐2ß‐carbomethoxy‐3ß‐(4‐iodophenyl) nortropane ([123I] FP‐CIT) SPECT scan data, which were concordant in every case.All analyses were carried out by observers blinded to the clinical details and supplied with just the spiral drawings, from which tremor severity (TS), 3‐turn spiral diameter (3TD), and spiral density (SD) were measured.Results:The spirals drawn by TDPD cases had significantly smaller 3TD (P = 0.029) and greater SD (P = 0.0082) than those with normal FP‐CIT scans. There was no significant difference in the TS between the two groups (P = 0.11). The sensitivity and specificity of TS were 62.5% and 65.0%, 3TD were 75% and 56.7%, and SD were 30.4% and 82.5%, respectively, in predicting the correct classification. Further analyses combining these factors into pairs, showed that the respective sensitivities and specificities of (1) TS × 3TD were 75.0% and 40.0%, (2) TS/SD were 56% and 70.0%, and (3) 3TD/SD were 87.0% and 40.0%.Discussion:There are significant differences in the 3TD and SD of spirals drawn by tremulous patients with normal versus abnormal FP‐CIT scans. Spiral analysis may have some clinical value in helping to distinguish tremulous parkinsonian patients with normal presynaptic dopaminergic imaging from tremulous PD patients, providing results similar to those reported for expert movement disorder neurologists using standardized videotaped examinations. © 2011 Movement Disorder Society
The c.‐237_236GA>TT THAP1 sequence variant does not increase risk for primary dystonia
Authors: Xiao Jianfeng , Zhao Yu , Bastian Robert W. , Perlmutter Joel S. , Racette Brad A. , Tabbal Samer D. , Karimi Morvarid , Paniello Randal C. , Wszolek Zbigniew K. , Uitti Ryan J. , Van Gerpen Jay A. , Simon David K. , Tarsy Daniel , Hedera Peter , Truong Daniel D. , Frei Karen P. , Blitzer Andrew , Rudzińska Monika , Pfeiffer Ronald F. , Le Carrie , LeDoux Mark S. 
Published: March 2011

AbstractBackground: Sequence variants in coding and noncoding regions of THAP1 have been associated with primary dystonia.Methods: In this study, 1,446 Caucasian subjects with mainly adult‐onset primary dystonia and 1,520 controls were genotyped for a variant located in the 5′‐untranslated region of THAP1 (c.‐237_236GA>TT).Results: Minor allele frequencies were 62/2892 (2.14%) and 55/3040 (1.81%) in subjects with dystonia and controls, respectively (P=0.202). Subgroup analyses by gender and anatomical distribution also failed to attain statistical significance. In addition, there was no effect of the TT variant on expression levels of THAP1 transcript or protein.Discussion: Our findings indicate that the c.‐237_236GA>TT THAP1 sequence variant does not increase risk for adult‐onset primary dystonia in Caucasians. © 2011 Movement Disorder Society
A new familial syndrome with dystonia and lower limb action myoclonus
Authors: Groen Justus , van Rootselaar Anne‐Fleur , van der Salm Sandra M. A. , Bloem Bastiaan R. , Tijssen Marina 
Published: March 2011

AbstractBackground:Myoclonus‐dystonia (M‐D) is genetic and clinically heterogeneous. Identification and description of rare M‐D syndromes may contribute to gene identification.Results:Here, we describe a new, autosomal dominant M‐D syndrome in a 3‐generation pedigree showing anticipation. Patients have progressive action‐induced multifocal dystonia and generalized myoclonus. A remarkable feature of the syndrome is action myoclonus in the lower extremities triggered by upright posture, causing instability. Electrophysiological characterization shows a 12‐Hz peak in the EMG autospectrum and corticomuscular and intermuscular coherences.Conclusions:A new familial M‐D syndrome with progressive action myoclonus and dystonia is described. © 2011 Movement Disorder Society
The free vascularized fibular graft for bridging large skeletal defects of the upper extremity
Authors: Soucacos Panayotis N. , Korompilias Anastasios V. , Vekris Marios D. , Zoubos Aristides , Beris Alexandros E. 
Published: March 2011

AbstractLarge skeletal defects of the upper extremity pose a serious clinical problem with potentially deleterious effects on both function and viability of the limb. Recent advances in the microsurgical techniques involved in free vascularized bone transfers for complex limb injuries have dramatically improved limb salvage and musculoskeletal reconstruction. This study evaluates the clinical and radiographic results of 18 patients who underwent reconstruction of large defects of the long bones of the upper extremity with free vascularized fibular bone grafts. Mean patient age was 27 years (7−43 years) and mean follow‐up was 4 years (1−10 years). The results confirm the value of vascularized fibular grafts for bridging large bone defects in the upper extremity. © 2011 Wiley‐Liss, Inc. Microsurgery 2011.
Long‐term outcome of bilateral Wilms tumors (BWT)
Authors: Aronson Daniel C. , Slaar Annelie , Heinen Richard C. , de Kraker Jan , Heij Hugo A. 
Published: March 2011

AbstractBackgroundModern WT management consist of ample chemotherapy, nephron‐sparing surgery, and, when indicated, radiotherapy. Survivors may develop renal failure or secondary tumors due to anticancer treatment. We analyzed long‐term outcome (follow‐up >5 years) after bilateral Wilms tumor (BWT) treatment with respect to survival, renal function, and secondary malignancies.MethodsFrom 41 patients (23 females, 28 synchronous tumors) diagnosed with BWT between 1967 and 2007, 25 (18 females, 14 synchronous) with a follow‐up >5 years could be included. Of this subgroup, median age at diagnosis was 1.64 years (range 0.27–5.35), and at maximum follow‐up 14.99 years (range 5.40–33.99). Data were retrospectively collected and analyzed.ResultsOne patient (4%) died 17.75 years after diagnosis, five (20%) had renal transplants: 3/5 after bilateral nephrectomy for Denys–Drash syndrome (DDS), and 2/5 for ESRD after an interval of 7 and 18 years, respectively. All transplanted patients remained in CR. Another three patients developed mild renal insufficiency (creatinine levels 1.3, 1.8, and 2.8 mg/100 ml, respectively; N = 0.5–1.2), combined with hypertension in 1; neither of them was transplanted. Sixteen (64%) had normal renal function and were in CR. Long‐term renal function appeared significantly better after bilateral nephron sparing surgery (NSS) then after other surgical procedures (P < 0.0001). Seven secondary tumors were found in five (20%) patients, one of whom had a DDS.ConclusionLong‐term 10‐year overall survival was 78%. There was significant morbidity (13/25, 52%), in terms of renal failure (8/25, 32%) including renal transplantation (5/25, 20%), and secondary tumors (5/25). These findings necessitate long‐term follow‐up beyond childhood. Future work should be directed at reducing the harmful effects of treatment, including the increased use of NSS. Pediatr Blood Cancer 2011;56:1110–1113. © 2011 Wiley‐Liss, Inc.
Ovarian‐sparing surgery for ovarian teratoma in children
Authors: Chabaud‐Williamson M. , Netchine I. , Fasola S. , Larroquet M. , Lenoir M. , Patte C. , Bénifla J.L. , Coulomb‐L'herminé A. , Grapin C. , Audry G. , Auber F. 
Published: March 2011

AbstractBackgroundOvarian teratoma (OT) is the most common ovarian neoplasm in children. Oophorectomy has been the standard treatment but may impair fertility. The aim of this study was to investigate the feasibility and outcome of ovarian‐sparing surgery (OSS) for OT.ProcedureWe retrospectively studied all children treated for OT at a pediatric teaching hospital in Paris, France, between March 1992 and July 2006. OSS was performed when deemed technically feasible in patients who had no lymphadenopathy by preoperative imaging or surgical exploration, normal tumor marker levels, and calcifications on radiographs.ResultsWe identified 30 patients, including 29 with unilateral OT and 1 with synchronous bilateral OT. Emergent surgery was performed in five patients, among whom four had ovarian torsion requiring oophorectomy and one underwent OSS. Of the 26 OTs in the 25 remaining patients, 10 were managed with OSS and 16 with oophorectomy. Subsequently, ultrasound monitoring detected OT development in the contralateral ovary in 4 (14%) patients, after a median of 3 years (range, 1–14 years); OSS was performed in all four cases. The patient with bilateral synchronous OT, managed by OSS initially, underwent unilateral oophorectomy 3 years later for a recurrence. Overall OSS was performed for 15 (42%) OTs.ConclusionsOur results suggest recommendations for preserving fertility whenever possible without compromising the oncological prognosis. In particular, OSS should be reserved for patients who meet all criteria for localized mature teratoma. Long‐term follow‐up is crucial. Pediatr Blood Cancer 2011; 57: 429–434. © 2011 Wiley‐Liss, Inc.
Controlling mobility and birefringence of azo chromophores in epoxy polymers
Authors: Sáiz Luciana M , Orofino Antonela B , Ruzzo María M , Arenas Gustavo F , Oyanguren Patricia A , Galante María J 
Published: March 2011

AbstractPolymers containing azobenzene units are of special interest due to the reversibility of their photo‐orientation. Applications of these materials are in the fields of optical information storage, information processing, optical switching devices and others. In the work reported, we synthesized, characterized and compared the optical behaviour of azo‐modified epoxy polymers. With this goal in mind, Disperse Red 13 was selected as azo chromophore and two different amines, N,N‐benzyldimethylamine and 4‐(dimethylamine)pyridine, as initiators of the epoxy homopolymerization. The influence of the degree of union between azo chromophore and matrix in crosslinked polymers, and, in consequence, the azo mobility, on the optical behaviour (birefringence and dichroism) of resulting films was evaluated. An analysis of the dynamics of the writing and relaxation processes was also carried out. When the azo chromophore was covalently linked to the network, the maximum birefringence was reached three times faster. Also, two completely different optical behaviours were observed taking into account the occurrence or not of covalent bonding between the chromophore and the matrix. A remnant birefringence of around 60% was retained in the first case; an on‐off optical behaviour was observed in the second case. Copyright © 2011 Society of Chemical Industry
A comparative study of the preparation and physical properties of polystyrene–silica mesocomposite and nanocomposite materials
Authors: Weng Chang‐Jian , Huang Kuan‐Yeh , Chiu Wen‐Ling , Yeh Jui‐Ming , Wei Yen , Liu Sung‐Po , Hwang Shyh‐Shin 
Published: March 2011

AbstractIn this paper, a comparative study with regard to the preparation and physical properties of as‐prepared polystyrene–silica mesocomposite (PSM) and polystyrene‐silica nanocomposite (PSN) materials is presented. Vinyl‐modified mesoporous silica particles with a wormhole structure were first prepared by doping a sol‐gel metal oxide with an optically active non‐surfactant (dibenzoyl‐L‐tartaric acid) as a template, followed by template removal through Soxhlet extraction. The as‐prepared silica particles with/without mesopores were subsequently characterized using the Brunauer–Emmett–Teller method and transmission electron microscopy (TEM) and Fourier transform infrared, 13C NMR and 29Si NMR solid‐state spectroscopy. A specific feed amount of silica particles was subsequently reacted with styrene monomer by free radical polymerization to yield a series of PSM and corresponding PSN materials. Both as‐prepared composite systems were further characterized using TEM and scanning electron microscopy/energy‐dispersive X‐ray mapping studies. A systematic comparative study of the physical properties of both as‐prepared composite materials clearly illustrated that PSM had effectively enhanced thermal stability, optical clarity and dielectric properties compared to the corresponding PSN counterpart. Evaluation was carried out using thermogravimetric analysis, differential scanning calorimetry, UV‐visible transmission spectroscopy and dielectric constant measurements. Copyright © 2011 Society of Chemical Industry
Reflective secondary optical elements for fresnel lens based concentrator modules
Authors: Jaus J. , Bett A.W. , Reinecke H. , Weber E.R. 
Published: March 2011

AbstractThis paper reports on the development of secondary optics for concentrator photovoltaic (CPV) modules. It focuses on reflective secondary optics designed for high concentration modules using fresnel lenses as the primary concentrating optics. The development of the secondary optics was guided by the idea of designing an optical element suitable for cost effective mass production. The primary concentrating optics of a CPV module can direct only a limited part of the solar aureole (the immediate surroundings of the sun) onto the solar cell. The same applies to light impinging non‐perpendicular to the optical axis of the module (e.g., due to misalignment of the module). Therefore, one of the main functions of reflective secondary optics is to redirect light onto the solar cell that would otherwise not reach it. In order to analyze the performance of secondary optical elements (“secondaries”), a measurement setup is introduced that measures the angular photocurrent response of a CPV device with highly parallel light. This response is referred to as the “angular acceptance function” (AAF). The AAF is used to estimate the performance of the CPV device under various conditions with differing circumsolar radiation (CSR). A CPV test module was manufactured featuring III–V triple‐junction solar cells, a fresnel lens panel as the primary concentrator optic, and the newly developed reflective secondary. The results of a 6‐month outdoor measurement period are presented and compared to the performance of a reference module as well as to the results of the indoor AAF measurements. Copyright © 2011 John Wiley & Sons, Ltd.
Integrated proteome and metabolite analysis of the de‐etiolation process in plastids from rice (Oryza sativa L.)
Authors: Reiland Sonja , Grossmann Jonas , Baerenfaller Katja , Gehrig Peter , Nunes‐Nesi Adriano , Fernie Alisdair R. , Gruissem Wilhelm , Baginsky Sacha 
Published: March 2011

AbstractWe have analyzed the dynamics of the rice etioplast membrane proteome during the early phase of de‐etiolation using iTRAQ‐based relative protein quantification. Several hundred plastid proteins were identified from enriched membranes, including 36 putative transporters. Hierarchical clustering revealed the coordinated light induction of thylakoid membrane proteins with proteins involved in translation and fatty acid metabolism. No other functional category of identified proteins showed a similarly consistent light induction, and no consistent changes were observed for the identified transporters. This suggests that the etioplast metabolism is already primed to accommodate the metabolic changes that occur during the onset of photosynthesis. This hypothesis was further tested in metabolite profiling experiments. Here, the changes upon illumination are mostly restricted to a decrease in the concentration of some amino acids and an increase in the concentrations of aspartic acid, malic acid, fumaric acid, and succinic acid. These changes are consistent with a rapid activation of photosynthesis and subsequent rapid production of storage carbohydrates and proteins. The information at the proteome level and the parallel measurements of metabolite accumulation both support the view that only minor metabolic network reconstruction and modification of enzyme levels occurs during the first 4 h of etioplast to chloroplast differentiation.
Comparative analysis of fluorescence resonance energy transfer (FRET) and proximity ligation assay (PLA)
Authors: Mocanu Maria‐Magdalena , Váradi Tímea , Szöllősi János , Nagy Peter 
Published: March 2011

AbstractBoth fluorescence resonance energy transfer (FRET) and proximity ligation assay (PLA) are techniques used in the investigation of protein interactions but the latter has not been evaluated in a systematic way, prompting us to compare their performance quantitatively. Proteins were labeled with oligonucleotide‐ or fluorophore‐conjugated antibodies and their proximity was analyzed by flow cytometry in order to obtain statistically robust data. Both intermolecular and intramolecular PLA signals reached saturation at high expression levels. At the same time, the FRET efficiency was independent of, while the FRET signal exhibited a strict linear correlation with the expression levels of proteins. When the density of oligonucleotide‐ and fluorophore‐conjugated antibodies was systematically changed by competition with unlabeled antibodies the FRET signal was linearly proportional to the amount of bound fluorophore‐tagged antibodies, whereas the PLA signal was again saturated. The saturation phenomenon in PLA could not be eliminated by decreasing the duration of the rolling circle amplification reaction. Our data imply that PLA is a semiquantitative measure of protein colocalizations due to non‐linear effects in the reaction and that caution should be exercised when interpreting PLA data in a quantitative way.