bluuebunny/crossref_metadata_2025_split huggingface dataset:
SISTEM INFORMASI SELEKSI PENERIMAAN KARYAWAN BARU DAN MONITORING KINERJA KARYAWAN BARU PT BUMIPUTERA MAHA TERPERCAYA SEBAMBAN BARU BERBASIS WEB
Authors: Muin Agus Alim , Rusdina Rusdina , Ningsih Estri 
Published: May 2024

PT Bumiputera Maha Terpercaya (BMT) Sebamban Baru adalah salah satu cabang perusahaan yang bergerak di bidang jasa transportasi angkutan batubara. Seleksi penerimaan karyawan baru pada PT BMT prosesnya masih dilakukan secara manual. Hal ini membuat proses registrasi dan seleksi lambat, kesulitan merekap hasil seleksi, susah mencari data dan sering terjadi kesalahan seleksi karena banyaknya pelamar. Dari hasil penelitian di PT BMT Sebamban Baru dengan adanya “Sistem Informasi Seleksi Penerimaan Karyawan Baru dan Monitoring Karyawan Baru PT BMT Sebamban Baru Berbasis Web”ini dapat menyelesaikan masalah. Metode pengumpulan data didalam penelitian ini menggunakan metode observasi, wawancara dan studi dokumen. Sistem ini dibangun menggunakan PHP dan MySql sebagai databasenya.Sistem Informasi Seleksi Penerimaan Karyawan Baru dan Monitoring Karyawan Baru PT BMT Sebamban Baru Berbasis Web ini menyediakan fasilitas, recruitment calon karyawan, tes tertulis dan wawancara, laporan hasil seleksi dan pengolahan berkas karyawan. Dengan diterapkannya sistem ini PT BMT Sebamban Baru diharapkan dapat mambantu mempermudah mengurangi kesalahan-kesalahan yang mungkin terjadi dan mempercepat dalam proses input, output pembuatan laporan yang dapat membantu admin merekap hasil seleksi karyawan PT BMT Sebamban Baru.
Rosmarinus officinalis and Centella asiatica Affect Interleukin-6 Zebrafish Larvae Induced High Glucose
Authors: Prastiwi Fajar Dwi , Lamadi Sutini , Khotimah Husnul , Wiyasa I Wayan Arsana , Raras Tri Yudani M. 
Published: May 2024

Gestational Diabetes Mellitus (GDM) is diabetes that occurs during pregnancy. GDM is characterized by hyperglycemia. Hyperglycemia causes an inflammatory response characterized by the excretion of pro-inflammatory cytokines, one of which is IL-6. Centella asiatica and Rosmarinus officinalis are known as anti-diabetic and anti-inflammatory. This study aims to study the effect of the combination of nanoemulsion Centella asiatica and Rosmarinus officinalis on the expression of Interleukin-6 in Zebrafish larvae induced by 3% glucose. Hyperglycemia is known from increased levels of Phosphoenolpyruvate carboxykinase in Zebrafish larvae. Phosphoenolpyruvate carboxykinase and Interleukin-6 expression were measured by conventional PCR method. The combination of Rosmarinus officinalis nanoemulsion and Centella asiatica was given with three different doses, namely at a concentration of 2.5, 5 and 10 µg/mL. The statistical analysis used was One Way ANOVA to measure Interleukin-6 expression levels. The results of this study prove that the combination of Rosmarinus officinalis and Centella asiatica nanoemulsions reduces the expression of Interleukin-6. The dose closest to the negative control was at a concentration of 5 μg/mL, although the final result was statistically significant (p<0.05). In conclusion, combining nanoemulsion Centella asiatica and Rosmarinus officinalis with the right dose reduced levels of Interleukin 6 in zebrafish larvae induced by high glucose.
MEMBANGUN KEMANDIRIAN SISWA DALAM BELAJAR MENUJU MASYARAKAT GOOD CITIZENSHIP
Authors: Lusie Putri Mas Fierna Janvierna , Utaminingsih Sri , Siswandi R Dede 
Published: May 2024

Seiring dengan berjalannya waktu dan perkembangan, seseorang akan belajar untuk mandiri. kemandirian adalah kemampuan remaja dalam berpikir, merasakan dan membuat keputusan secara pribadi berdasarkan diri sendiri dibandingkan mengikuti apa yang orang lain percayai. Membangun kemandirian siswa dalam belajar tugas dan kewajiban bagi seorang pendidik. Kemandirian tujuan guru agar siswa belajar mandiri, sesuai dengan tujuan kompetensi inti sikap dalam ranah afektif. Pembelajaran kemandirian sebagai transmisi kewarganegaraan berkaitan erat dengan penanaman tingkah laku siswa dalam belajar dan hidup bermasyarakat dalam kehidupan sehari-hari. Walaupun banyak kendala dalam belajar namun siswa-siswi tetap membangun kemandirian menjadi individu yang mandiri, disiplin, tanggung jawab, mampu menyelesaikan masalah, mengambil keputusan sendiri, inisiatif dan kreatif dalam belajar. Kemandirian juga di dukung oleh faktor ekternal yaitu guru dan orangtua. Guru selalu memberikan motivasi kepada siswa untuk mandiri dalam belajar, begitupun orangtua selalu memberikan bimbingan, nasehat, serta pantauan kepada anak-anakanya dirumah. Warga negara yang baik, yaitu masyarakat yang memiliki kecerdasan intelektual, emosional yang baik, kehidupan sosial yang baik, spiritual, rasa bangga terhadap tanah airnya, berpartisipasi dalam kehidupan bermasyarakat dan bernegara, tumbuh rasa kebangsaan dan cinta tanah air, kepribadian dan akhlak yang baik, bersikap demokratis, mampu bersaing dan berprestasi dalam bidangnya dan kemajuan teknologi dan komunikasi, terutama bertanggung jawab sebagai generasi muda
Peran Pendidikan Kewarganegaran dalam Membangun Sikap Toleransi Beragama pada Mahasiswa
Authors: Ahmad Humam Alwi , Najicha Fatma Ulfatun 
Published: May 2024

Indonesia merupakan negara dengan keragaman suku, ras, budaya, dan agama yang beranekaragam. Agama merupakan landasan kehidupan bagi setiap umat manusia, manakala pemahaman agama pada individu itu lemah, maka individu tersebut akan hilang arah dan tidak dapat mengetahui arah tujuan hidupnya, serta dapat dengan mudahnya dipengaruhi oleh individu lain. Agama merupakan peran yang penting dalam kehidupam setiap individu, sebab agama merupakan hal mendasar yang berkaitan dengan kepercayaan seorang individu. Selain itu agama juga memiliki keterkaitan dengan tradisi yang dimiliki oleh suatu kelompok masyarakat. Sikap yang harus dikedepankan oleh individu yang beragama dalam menyikapi adanya keberagaman agama di Indonesia ialah dengan sikap toleransi. Tanpa adanya toleransi akan menimbulkan perpecahan antar perbedaan, atau bahkan dapat menyebabkan rusaknya suatu wilayah yang disebabkan oleh perpecahan. Toleransi beragama merupakan sikap manusia dalam menyikapi adanya keberagaman agama. Maka dari itu, tidak dapat dibantah bahwa toleransi beragama merupakan hal yang penting agar tidak terjadi perpecahan. Selain itu, menjadi warga negara yang baik tidak semata-mata taat akan hukum atau menumbuhkan rasa kebangsaan saja, melainkan juga harus menumbuhkan rasa toleransi terhadap kemajemukan yang terdapat di Indonesia, khususnya keberagaman agama. Sehingga dengan adanya perbedaan agama atau kepercayaan tersebut, diperlukan ilmu pengetahuan dan pendidikan yang bertujuan guna menumbuhkan sikap toleransi, khususnya mahasiswa.
Penyelesaian Kasus Money Politic Tindak Pidana Pemilu (Studi Putusan Nomor 214/Pid.B/2019/PN Pal)
Authors: Tarigan Yos Arnold , Hamdan Muhammad , Ablisar Madiasa , Mulyadi Mahmud 
Published: May 2024

Pemilihan Umum merupakan wujud partisipasi politik rakyat dalam sebuah negara demokrasi. Praktik Money politics untuk memperoleh dukungan pemilih, masih tetap efektif dalam meraih sebanyak mungkin suara, guna melindungi kemurnian pemilihan umum yang sangat penting bagi demokrasi maka para pembuat Undang-undang telah menjadikan sejumlah perbuatan curang dalam pemilihan umum sebagai tindak pidana. Pertimbangan situasi yang telah disampaikan, dilakukan studi untuk memeriksa jenis-jenis kejahatan pemilu yang terjadi selama Pemilihan Umum tahun 2019 dan mencoba untuk mengevaluasi bagaimana pelaksanaan penyelesaian kasus kejahatan pemilu serta implementasi hukum dalam penanganan kasus kejahatan pemilu di Kota Palu. Penelitian ini menggunakan metode penelitian yuridis normatif dan bersifat deskriptis analitis. Penerapan hukum penanganan tindak pidana pemilu di (Studi Putusan Nomor 214/Pid.B/2019/PN Pal) mengacu kepada Pasal Undang-undang Pemilu, maka temuan dan laporan adanya dugaan pelanggaran pemilu yang mengandung unsur pidana. Koordinasi antara Panwaslu, Kepolisian, dan kejaksaan dalam melakukan pengawasan yang lebih efektif dan memberlakukan sanksi pidana terhadap perkara ini bertujuan untuk menciptakan efek jera terhadap pelaku dan menegaskan bahwa kepastian dan penegakan hukum bahwa hukum itu ada dan berjalan.
ДІАГНОСТИЧНИЙ ІНСТРУМЕНТАРІЙ ДОСЛІДЖЕННЯ МОРАЛЬНО-ПОВЕДІНКОВОГО КОМПОНЕНТА СОЦІАЛЬНОГО ІНТЕЛЕКТУ У ДОШКІЛЬНИКІВ З ІНТЕЛЕКТУАЛЬНИМИ ТРУДНОЩАМИ ЛЕГКОГО СТУПЕНЯ ПРОЯВУ ТА НОРМОТИПОВИМ РОЗВИТКОМ
Authors: Омельченко Ірина , Кобильченко Вадим 
Published: May 2024

У статті окреслено актуальність проблеми розроблення та апробації українського діагностико-наочного контенту для дослідження соціального інтелекту в дошкільників з інтелектуальними труднощами легкого ступеня прояву та нормотиповим розвитком. Розкрито, що наразі в українській спеціальній психології визначено необхідність дослідження у дошкільників з інтелектуальними труднощами легкого ступеня прояву морально-поведінкового компонента соціального інтелекту. Висвітлено, що розроблений авторами психодіагностичний інструментарій спрямований на дослідження морально-поведінкового компонента соціального інтелекту постає в здатності дитини до інтерпретації та оцінки вчинків інших, полягає в умінні ідентифікувати себе з іншими, умінні прогнозувати ситуацію залежно від скоєного вчинку; сформованості моральних інстанцій у дитини-дошкільника з інтелектуальними труднощами легкого ступеня прояву та нормотиповим розвитком. Обґрунтовано змістовий контент методики, яка складається із картинок, на яких відображена динаміка розгортання української народної казки «Ворона і гадюка» та портретні картинки з зображенням емоцій: 1) радості; 2) злості; 3) смутку; 4) страху; 5) подиву; 6) спокою (окремі набори для хлопчиків та дівчаток). Визначено специфіку розпізнання емоцій дошкільниками з інтелектуальними труднощами легкого ступеня прояву та дітьми з нормотиповим розвитком. Експериментально перевірено, що діти адекватно оцінюють героїв казки, засуджуючи поведінку гадюки та схвалюючи вчинок ворони. Більшість дошкільнят при ідентифікації себе з гадюкою відповідають, що вони не стали б їсти пташенят на місці гадюки. Вони здатні спрогнозувати негативне ставлення до героя у зв’язку з його поведінкою. Так, наприклад, діти кажуть, що з гадюкою не дружать, «бо вона зла (сердита, погана)».
Теоретично обґрунтовано, що перспективи подальших наукових студій полягатимуть в інтерпретації результатів експерименту, який засвідчує стан сформованості морально-поведінкового компонента соціального інтелекту дошкільників з інтелектуальними труднощами легкого ступеня прояву.
Joint constraints from cosmic shear, galaxy-galaxy lensing and galaxy clustering: internal tension as an indicator of intrinsic alignment modelling error
Authors: Samuroff Simon , Campos Andresa , Porredon Anna , Blazek Jonathan 
Published: May 2024

In cosmological analyses it is common to combine different types of measurement from the same survey. In this paper we use simulated DES Y3 and LSST Y1 data to explore differences in sensitivity to intrinsic alignments (IA) between cosmic shear and galaxy-galaxy lensing. We generate mock shear, galaxy-galaxy lensing and galaxy clustering data, contaminated with a range of IA scenarios. Using a simple 2-parameter IA model (NLA) in a DES Y3 like analysis, we show that the galaxy-galaxy lensing + galaxy clustering combination ( 2×2pt) is significantly more robust to IA mismodelling than cosmic shear. IA scenarios that produce up to 5σ biases for shear are seen to be unbiased at the level of ∼1σ for 2×2pt. We demonstrate that this robustness can be largely attributed to the redshift separation in galaxy-galaxy lensing, which provides a cleaner separation of lensing and IA contributions. We identify secondary factors which may also contribute, including the possibility of cancellation of higher-order IA terms in 2×2pt and differences in sensitivity to physical scales. Unfortunately this does not typically correspond to equally effective self-calibration in a 3×2pt analysis of the same data, which can show significant biases driven by the cosmic shear part of the data vector. If we increase the precision of our mock analyses to a level roughly equivalent to LSST Y1, we find a similar pattern, with considerably more bias in a cosmic shear analysis than a 2×2pt one, and significant bias in a joint analysis of the two. Our findings suggest that IA model error can manifest itself as internal tension between ξ± and γt+w data vectors. We thus propose that such tension (or the lack thereof) can be employed as a test of model sufficiency or insufficiency when choosing a fiducial IA model, alongside other data-driven methods.
Costs and benefits in patients with NYHA class III heart failure treated with CardioMEMS in Italy
Authors: Messori Andrea , Romeo Maria Rita , Fadda Valeria , Collini Francesca , Trippoli Sabrina 
Published: May 2024

Background: CardioMEMS is a device suitable for telemedicine that is currently being evaluated by the Regional Health Technology Assessment (HTA) Committee of Tuscany. Two detailed HTA reports are available in the specialized literature, the results of which need to be transferred to our regional setting. These decisions in Tuscany are made by the so-called Centro Operativo HTA. Aim: To validate, with local cost-effectiveness data, the decision on CardioMEMS that will be made in the Tuscany region. Methods: Two detailed international HTA reports were rearranged and adapted to our regional setting to generate a simplified analysis that could form the basis of our decision. Two willingness-to-pay (WTP) thresholds of €20,000/quality-adjusted life year (QALY) and €50,000/QALY were considered. Results: Based on epidemiological and regulatory information, the target population in Tuscany for this device is 166 cases. The value-based price of CardioMEMS is estimated to be €4,332 and €16,662 at WTP thresholds of 20,000/QALY and 50,000/QALY, respectively. Its current price in Italy is €12,000. Conclusion: In our region, the introduction of CardioMEMS is likely to be gradual, around 50 patients/year (or €0.60 million/year at current price). This example highlights the need to adapt the information published in the international literature to the local context in which the approval decision is made. In this context, simplified analyses are easier to apply than complex Markov models.
Atosiban interacts with growth hormones as adjuvants in frozen-thawed embryo transfer cycles
Authors: Chen Haixiao , Cai Jiali , Sun Xiaohua , Liu Lanlan , Liu Zhenfang , Gao Peng , Jiang Xiaoming , Ren Jianzhi 
Published: May 2024

ObjectiveTo investigate the interaction between atosiban and growth hormone (GH) as adjuvants in frozen-thawed embryo transfer (FET) cyclesMethodA total of 11627 patients who underwent FET at Xiamen University Affiliated Chenggong Hospital between January 2018 to December 2022 were retrospectively analyzed. Among them, 482 patients received atosiban and 275 patients received GH. The interactions were estimated by comparing the odds ratio (OR) for pregnancy comparing patients with or without atosiban adjuvant in cohorts stratified according to the presence of GH use in either the overall cohort or a propensity score (PS) matched cohort. An interaction term (atosiban × GH) was introduced to a multivariate model to calculate the ratio of OR (ORR) adjusted for confounders.ResultsFor all patients receiving atosiban administration, no obvious effect on pregnancy was observed in comparison with either matched or unmatched controls. However, when the patients were stratified according to GH administration, atosiban showed a significant association with clinical pregnancy in comparison with either matched or unmatched controls among patients with GH treatment with rate ratios (RR) of 1.32 (95%CI: 1.05,1.67) and 1.35 (95%CI: 1,1.82), respectively. On the other hand, however, the association was absent among patients without GH treatment. The adjusted ORRs in both matched and unmatched cohorts were 2.44 (95%CI: 1.07,5.84) and 1.95 (95%CI: 1.05, 3.49) respectively.ConclusionThe combination use of atosiban and GH in FET cycles is potentially beneficial to the pregnancy. However, indications for the use of atosiban and GH may need further assessment.
Exploring the dynamics of monkeypox transmission with data-driven methods and a deterministic model
Authors: Das Haridas K. 
Published: May 2024

IntroductionMpox (formerly monkeypox) is an infectious disease that spreads mostly through direct contact with infected animals or people's blood, bodily fluids, or cutaneous or mucosal lesions. In light of the global outbreak that occurred in 2022–2023, in this paper, we analyzed global Mpox univariate time series data and provided a comprehensive analysis of disease outbreaks across the world, including the USA with Brazil and three continents: North America, South America, and Europe. The novelty of this study is that it delved into the Mpox time series data by implementing the data-driven methods and a mathematical model concurrently—an aspect not typically addressed in the existing literature. The study is also important because implementing these models concurrently improved our predictions' reliability for infectious diseases.MethodsWe proposed a traditional compartmental model and also implemented deep learning models (1D- convolutional neural network (CNN), long-short term memory (LSTM), bidirectional LSTM (BiLSTM), hybrid CNN-LSTM, and CNN-BiLSTM) as well as statistical time series models: autoregressive integrated moving average (ARIMA) and exponential smoothing on the Mpox data. We also employed the least squares method fitting to estimate the essential epidemiological parameters in the proposed deterministic model.ResultsThe primary finding of the deterministic model is that vaccination rates can flatten the curve of infected dynamics and influence the basic reproduction number. Through the numerical simulations, we determined that increased vaccination among the susceptible human population is crucial to control disease transmission. Moreover, in case of an outbreak, our model showed the potential for epidemic control by adjusting the key epidemiological parameters, namely the baseline contact rate and the proportion of contacts within the human population. Next, we analyzed data-driven models that contribute to a comprehensive understanding of disease dynamics in different locations. Additionally, we trained models to provide short-term (eight-week) predictions across various geographical locations, and all eight models produced reliable results.ConclusionThis study utilized a comprehensive framework to investigate univariate time series data to understand the dynamics of Mpox transmission. The prediction showed that Mpox is in its die-out situation as of July 29, 2023. Moreover, the deterministic model showed the importance of the Mpox vaccination in mitigating the Mpox transmission and highlighted the significance of effectively adjusting key epidemiological parameters during outbreaks, particularly the contact rate in high-risk groups.
Three exonic variants in the PHEX gene cause aberrant splicing in a minigene assay
Authors: Pan Fengjiao , Zhang Ruixiao , Liu Xuyan , Shi Xiaomeng , Xin Qing , Qiao Dan , Li Changying , Zhang Yan , Chen Mengke , Guo Wencong , Luan Shufang , Shao Leping 
Published: May 2024

Background: X-linked hypophosphatemia (XLH, OMIM 307800) is a rare phosphorus metabolism disorder caused by PHEX gene variants. Many variants simply classified as missense or nonsense variants were only analyzed at the DNA level. However, growing evidence indicates that some of these variants may alter pre-mRNA splicing, causing diseases. Therefore, this study aimed to use bioinformatics tools and a minigene assay to ascertain the effects of PHEX variations on pre-mRNA splicing.Methods: We analyzed 174 variants in the PHEX gene described as missense or nonsense variants. Finally, we selected eight candidate variants using bioinformatics tools to evaluate their effects on pre-mRNA splicing using a minigene assay system. The complementary DNA (cDNA) sequence for the PHEX gene (RefSeq NM_000444.6) serves as the basis for DNA variant numbering.Results: Of the eight candidate variants, three were found to cause abnormal splicing. Variants c.617T&gt;G p.(Leu206Trp) and c.621T&gt;A p.(Tyr207*) in exon 5 altered the splicing of pre-mRNA, owing to the activation of a cryptic splice site in exon 5, which produced an aberrant transcript lacking a part of exon 5, whereas variant c.1700G&gt;C p.(Arg567Pro) in exon 16 led to the activation of a cryptic splice site in intron 16, resulting in a partial inclusion of intron 16.Conclusion: Our study employed a minigene system, which has a great degree of flexibility to assess abnormal splicing patterns under the circumstances of patient mRNA samples that are not available, to explore the impact of the exonic variants on pre-mRNA splicing. Based on the aforementioned experimental findings, we demonstrated the importance of analyzing exonic variants at the mRNA level.
Post-drought leads to increasing metabolic rates in the surface waters of a natural tropical lake
Authors: Brighenti Ludmila Silva , Viana Elisa Aguiar Porto , Pujoni Diego Guimarães Florêncio , Barbosa Francisco Antônio Rodrigues , Bezerra-Neto José Fernandes 
Published: May 2024

As hotspots of the global carbon cycle, lakes can regulate climate change while being regulated by it via a feedback loop. As ecosystem metabolism is considered to be a sentinel to these changes, we used high-frequency measurements and the inverse modeling approach to study the temporal dynamic of gross primary production (GPP), respiration (R), and net ecosystem production (NEP) at surface waters of a tropical lake, which lost about 60% of its volume in almost 10 years. This water loss and the return of the average rainfall led to an increased concentration of nitrogen, phosphorus, and dissolved organic carbon and decreased water transparency and light availability. During the post-drought period, epilimnetic GPP increased by 40% compared with the pre-drought period, and R surpassed GPP during the mixing period of the lake. We discuss that this modification results from higher carbon and nutrient concentrations, lower light availability, and a change in the lake stratification pattern. Surface water metabolism changed due to meteorological and hydrological drought, and it may continue to change under the ongoing variation in rainfall patterns, temperature, and human disturbances.