bluuebunny/crossref_metadata_2025_split huggingface dataset:
GUIDEWIRE SHAPE MODIFICATION: A SIMPLE TECHNIQUE TO PREVENT CONDUCTION SYSTEM INJURIES DURING TRANSCATHETER VALVE IMPLANTATION
Authors: Azzola Guicciardi N , Buzzatti N , Longoni M , Denti P , Faggi A , Ascione G , Gatto P , Godino C , Saccocci M , Maisano F 
Published: May 2024

Abstract

Background
Atrioventricular (AV) conduction abnormalities remain one of the important unsolved issues with transcatheter aortic valve implantation (TAVI). To minimize trauma on the conduction fibers, we introduced a simple technique involving the bending of the stiff guidewire wire at the level of the arch to prevent and minimize contact with the interventricular septum.

Aim
To report the technique for shape manipulation of the stiff guidewire during TAVI and to evaluate its safety and effectiveness in reducing the need for permanent pace–make implantation after TAVI.

Methods and Results
Before insertion into the left ventricle the TAVI stiff wire was bended by hand to obtain a ³180° degree curve 15–20cm from its tip. Distance between stiff wire and septum was assessed in cranial–lao cusp overlap projection. Among 26 consecutive patients who underwent TAVI with a bended stiff wire, 13(50%) presented preoperative factors of increased risk for need of PM implantation after TAVI due to LVOT calcification (10, 38.5%), bicuspid aortic valve with raphe opposite to the septum (2, 7.7%) and baseline RBBB (2, 7.7%). Wire was observed to be distant from the septum &gt;5mm in 22/26 (85%) cases. Median distance from septum was 9.0 [6.0, 12.0] mm. Pre–dilatation was required in 20 patients (77%). Balloon was observed to inflate distant from septum in 18 (90%) of them. Self–expandable valves were most frequently employed (n = 21, 81%).No patient required new PM implantation after TAVI. The two patients with baseline RBBB developed transient complete AVB, which recovered before discharge.No major complication (vascular, ventricular perforation, annular rupture, device embolization) was observed.

Conclusions
In this early preliminary experience stiff wire bending was able not only to keep far from the septum the wire in the majority of patients, without any complication, but also to provide wire stability and prevented inadvertent pressure of the wire over the left ventricular apex. No patient required PM implantation after TAVI. While wire bending seems promising in minimizing trauma on the conduction system, this study is to be considered hypothesis generating and more data are needed to confirm its findings.
3D CT Radiomic Analysis Improves Detection of Axillary Lymph Node Metastases Compared to Conventional Features in Patients With Locally Advanced Breast Cancer
Authors: Barszczyk Mark , Singh Navneet , Alikhassi Afsaneh , Van Oirschot Matthew , Kuling Grey , Kiss Alex , Gandhi Sonal , Nofech-Mozes Sharon , Look Hong Nicole , Bilbily Alexander , Martel Anne , Matsuura Naomi , Curpen Belinda 
Published: May 2024

Abstract

Objective
Preoperative detection of axillary lymph node metastases (ALNMs) from breast cancer is suboptimal; however, recent work suggests radiomics may improve detection of ALNMs. This study aims to develop a 3D CT radiomics model to improve detection of ALNMs compared to conventional imaging features in patients with locally advanced breast cancer.

Methods
Retrospective chart review was performed on patients referred to a specialty breast cancer center between 2015 and 2020 with US-guided biopsy-proven ALNMs and pretreatment chest CT. One hundred and twelve patients (224 lymph nodes) met inclusion and exclusion criteria and were assigned to discovery (n = 150 nodes) and testing (n = 74 nodes) cohorts. US-biopsy images were referenced in identifying ALNMs on CT, with contralateral nodes taken as negative controls. Positive and negative nodes were assessed for conventional features of lymphadenopathy as well as for 107 radiomic features extracted following 3D segmentation. Diagnostic performance of individual and combined radiomic features was evaluated.

Results
The strongest conventional imaging feature of ALNMs was short axis diameter ≥ 10 mm with a sensitivity of 64%, specificity of 95%, and area under the curve (AUC) of 0.89 (95% CI, 0.84-0.94). Several radiomic features outperformed conventional features, most notably energy, a measure of voxel density magnitude. This feature demonstrated a sensitivity, specificity, and AUC of 91%, 79%, and 0.94 (95% CI, 0.91-0.98) for the discovery cohort. On the testing cohort, energy scored 92%, 81%, and 0.94 (95% CI, 0.89-0.99) for sensitivity, specificity, and AUC, respectively. Combining radiomic features did not improve AUC compared to energy alone (P = .08).

Conclusion
3D radiomic analysis represents a promising approach for noninvasive and accurate detection of ALNMs.
Reconstructing Nasal Defects With Acellular Dermal Matrix After Mohs Micrographic Surgery: A 12-year Experience
Authors: Bascone Corey M. , Lin Stephanie K. , Deitermann Annika , Raj Leela K. , Nugent Shannon T. , Wang Leo , McGraw J. Reed , Broach Robyn B. , Miller Christopher J. , Kovach Stephen J. 
Published: May 2024

BACKGROUND AND OBJECTIVE
Large defects of the nose after Mohs surgery pose a significant reconstructive challenge to both dermatologic and reconstructive surgeons. The authors present their 12-year experience utilizing acellular dermal matrices for nasal reconstruction.

METHODS
A retrospective review of patients undergoing Mohs surgery and alloplastic nasal reconstruction with acellular dermal matrices between 2010 and 2022 was performed. Patients who underwent single-stage reconstruction and dual-stage reconstruction with skin graft with at least 90 days of follow-up were included.

RESULTS
Fifty-one patients met criteria with a median age of 77 years. Fifty-three lesions were reconstructed with acellular dermal matrices. The most common lesion location was nasal sidewall (50%) with a mean defect size of 10.8 cm2. 30.8% underwent same-day acellular dermal matrix reconstruction, with 69.2% undergoing two-stage reconstruction. Acellular dermal matrices successfully reconstructed acquired defects in 94.2% of lesions. Average time to re-epithelialization was 27.6 + 6.2 days. Average time to repigmentation was 145.35 + 86 days. No recurrences were recorded. Total complication rate was 9.62%. Average size for successful healing was 10.8 cm2. Average defect size for complication or failure was 14.7 cm2. Seven sites (13.46%) underwent aesthetic improvement procedures.

CONCLUSION
Acellular bilayer wound matrix is an adequate reconstructive option for single or dual-stage reconstruction of the nose with low complication and revision rates.
Method Validation Study of Dipstick Urinalysis as a Screening Tool for Sodium Nitrite Toxicity
Authors: Schmitt Jessicia S. , Knight Laura D. 
Published: May 2024

Abstract
The incidence of suicide by intentional nitrite ingestion has increased since 2017. Limited options exist for commercial laboratory analysis for nitrite/nitrate. This study investigates the use of urine dipsticks for screening at autopsy for potential toxicity with sodium nitrite and, less commonly, alkyl nitrite. Archived samples of blood, urine, vitreous fluid, and gastric contents from 4 sodium nitrite/nitrate cases, 3 alkyl nitrite cases, and 4 control cases were tested using dipsticks. A rapid, strong positive result for nitrite was in the vitreous fluid of all 4-sodium nitrite/nitrate cases, along with 2 positive urine and 1 positive gastric. The 2 alkyl nitrite inhalation toxicity cases had no positive results. One alkyl nitrite ingestion case had a positive urine. The 4 controls had negative urine: equivocal results in 2 vitreous, and 1 positive gastric. Urine dipsticks are a useful adjunct to laboratory testing for nitrite toxicity and provide a rapid, cost-effective tableside result that may guide the need for further testing. Vitreous fluid and urine appear to be the most reliable specimens, although testing of gastric liquid may be useful to corroborate oral ingestion. Dipsticks may not be a reliable adjunct for testing for alkyl nitrite toxicity via inhalation route, likely due to the much lower nitrite concentration compared to nitrite ingestion cases.
Improving Pneumococcal Vaccination Rates in Immunosuppressed Pediatric Patients with Rheumatic Disease
Authors: Harris Julia G. , Jones Jordan T. , Favier Leslie , Fox Emily , Holland Michael J. , Ivy Amy , Hoffart Cara M. , Ibarra Maria , Cooper Ashley M. 
Published: May 2024

Background:
Patients with rheumatic diseases are at a high risk of invasive pneumococcal disease due to immunosuppression. We conducted a quality improvement project, and the first aim was to increase the percentage of patients with systemic lupus erythematosus and mixed connective tissue disease that is up to date on pneumococcal vaccinations from 9.6% to 80% within one year. Subsequently, the second aim was to increase the percentage of patients on immunosuppression with systemic lupus erythematosus, mixed connective tissue disease, juvenile dermatomyositis and systemic vasculitis that is up to date on pneumococcal vaccinations from 62.6% to 80% within one year.

Methods:
Two process measures were up-to-date vaccination status on (1) 13-valent pneumococcal conjugated vaccine (PCV13) and (2) 23-valent pneumococcal polysaccharide vaccine (PPSV23). Our outcome measure was being fully up to date on both pneumococcal vaccinations. Interventions included an immunization algorithm, reporting of eligible patients, education, reminders, and pre-visit planning.

Results:
There were shifts in the centerline for all quality measures in both phases of this project. The combined pneumococcal vaccination rate for Phase 1 increased from 9.6% to 91.1%, and this centerline was sustained. Pneumococcal vaccination rates also significantly increased for Phase 2: 68.8% to 93.4% for PCV13, 65.2% to 88.5% for PPSV23, and 62.6% to 86.5% for the combined pneumococcal vaccination rate.

Conclusions:
Quality improvement methodology significantly increased and sustained pneumococcal vaccination rates in our high-risk, immunosuppressed patients. We continue to prioritize this important initiative to mitigate the risk of invasive pneumococcal disease.
Classifying Genetic Interactions Using an HIV Experimental Study
Authors: Huckleberry Sean C. , Silva Mary S. , Drocco Jeffrey A. 
Published: May 2024

AbstractCurrent methods of addressing novel viruses remain predominantly reactive and reliant on empirical strategies. To develop more proactive methodologies for the early identification and treatment of diseases caused by viruses like HIV and Sars-CoV-2, we focus on host targeting, which requires identifying and altering human genetic host factors that are crucial to the life cycle of these viruses. To this end, we present three classification models to pinpoint host genes of interest. For each one, we thoroughly analyze the current predictive accuracy, susceptibility to modifications of the input space, and potential for further optimization. Our methods rely on the exploration of different gene representations, including graph-based embeddings and large foundation transformer models, to establish a set of baseline classification models. Subsequently, we introduce an order-invariant Siamese neural network that exhibits more robust pattern recognition with sparse datasets while ensuring that the representation does not capture unwanted patterns, such as the directional relationship of genetic interactions. Through these models, we generate biological features that predict pairwise gene interactions, with the intention of extrapolating this proactive therapeutic approach to other virus families.
Phenotype correlations with pathogenic DNA variants in theMUTYHgene
Authors: Thet Monica , Plazzer John Paul , Capella Gabriel , Latchford Andrew , Nadeau Emily AW , Greenblatt Marc S , Macrae Finlay 
Published: May 2024

AbstractMUTYH-associated polyposis (MAP) is an autosomal recessive disorder where the inheritance of constitutional biallelic pathogenicMUTYHvariants predisposes a person to the development of adenomas and colorectal cancer (CRC). It is also associated with extracolonic and extraintestinal manifestations that may overlap with the phenotype of familial adenomatous polyposis (FAP). Currently, there are discrepancies in the literature regarding whether certain phenotypes are truly associated with MAP. This narrative review aims to explore the phenotypic spectrum of MAP to better characterise the MAP phenotype. A literature search was conducted to identify articles reporting on MAP-specific phenotypes. Clinical data from 2109 MAP patients identified from the literature showed that 1123 patients (53.2%) had CRC. Some patients with CRC had no associated adenomas, suggesting that adenomas are not an obligatory component of MAP. Carriers of the two missense founder variants, and possibly truncating variants, had an increased cancer risk when compared to those who carry other pathogenic variants. It has been suggested that somatic G:C>T:A transversions are a mutational signature of MAP, and could be used as a biomarker in screening and identifying patients with atypical MAP, or in associating certain phenotypes with MAP. The extracolonic and extraintestinal manifestations that have been associated with MAP include duodenal adenomas, duodenal cancer, fundic gland polyps, gastric cancer, ovarian cancer, bladder cancer and skin cancer. The association of breast cancer and endometrial cancer with MAP remains disputed. Desmoids and Congenital Hypertrophy of the Retinal Pigment Epithelium (CHRPEs) are rarely reported in MAP, but have long been seen in FAP patients, and thus could act as a distinguishing feature between the two. This collection of MAP phenotypes will assist in the assessment of pathogenicMUTYHvariants using the American College of Medical Genetics and the Association for Molecular Pathology (ACMG/AMP) Variant Interpretation Guidelines, and ultimately improve patient care.
Activation of the 20S proteasome core particle prevents cell death induced by oxygen- and glucose deprivation in cultured cortical neurons
Authors: Salazar Ivan L. , Curcio Michele , Mele Miranda , Vetrone Rossela , Frisari Simone , Costa Rui O. , Caldeira Margarida V. , Trader Darci J , Duarte Carlos B. 
Published: May 2024

AbstractNeuronal damage in brain ischemia is characterized by a disassembly of the proteasome and a decrease in its proteolytic activity. However, to what extent these alterations are coupled to neuronal death is controversial since proteasome inhibitors were shown to provide protection in different models of stroke in rodents. This question was addressed in the present work using cultured rat cerebrocortical neurons subjected to transient oxygen- and glucose-deprivation (OGD) as a model for in vitro ischemia. Under the latter conditions there was a time-dependent loss in the proteasome activity, determined by cleavage of the Suc-LLVY-AMC fluorogenic substrate, and the disassembly of the proteasome, as assessed by native-polyacrylamide gel electrophoresis followed by western blot against Psma2 and Rpt6, which are components of the catalytic core and regulatory particle, respectively. Immunocytochemistry experiments against the two proteins also showed differential effects on their dendritic distribution. OGD also downregulated the protein levels of Rpt3 and Rpt10, two components of the regulatory particle, by a mechanism dependent on the activity of NMDA receptors and mediated by calpains. Activation of the proteasome activity, using an inhibitor of USP14, a deubiquitinase enzyme, inhibited OGD-induced cell death, and decreased calpain activity as determined by analysis of spectrin cleavage. Similar results were obtained in the presence of two oleic amide derivatives (B12 and D3) which directly activate the 20S proteasome. Together, these results show that proteasome activation prevents neuronal death in cortical neurons subjected to in vitro ischemia, indicating that inhibition of the proteasome is a mediator of neuronal death in brain ischemia.
Understand resist use online customer service chatbot: an integrated innovation resist theory and negative emotion perspective
Authors: Chang Tsung-Sheng , Hsiao Wei-Hung 
Published: May 2024

PurposeThe rise of artificial intelligence (AI) applications has driven enterprises to provide many intelligent services to consumers. For instance, customers can use chatbots to make relevant inquiries and seek solutions to their problems. Despite the development of customer service chatbots years ago, they require significant improvements for market recognition. Many customers have reported negative experiences with customer service chatbots, contributing to resistance toward their use. Therefore, this study adopts the innovation resistance theory (IRT) perspective to understand customers’ resistance to using chatbots. It aims to integrate customers’ negative emotions into a predictive behavior model and examine users’ functional and psychological barriers.Design/methodology/approachIn this study, we collected data from 419 valid individuals and used structural equation modeling to analyze the relationships between resistance factors and negative emotions.FindingsThe results confirmed that barrier factors affect negative emotions and amplify chatbot resistance influence. We discovered that value and risk barriers directly influence consumer use. Moreover, both functional and psychological barriers positively impact negative emotions.Originality/valueThis study adopts the innovation resistance theory perspective to understand customer resistance to using chatbots, integrates customer negative emotions to construct a predictive behavior model and explores users’ functional and psychological barriers. It can help in developing online customer service chatbots for e-commerce.
A bibliometric analysis of literature published on ChatGPT and GPT
Authors: Safdar Muhammad , Siddique Nadeem , Gulzar Ayesha , Adil Syed Adnan , Yasin Haisim , Khan Muhammad Ajmal 
Published: May 2024

Purpose
This study aims to analyse the literature published on ChatGPT and generative pre-trained transformer (GPT) available through Scopus to identify the top countries, institutions, authors, journals and titles in terms of publishing and citations in the area.The research also intends to determine the collaborative trends among countries and authors as well as top-used keywords on the topic identified from the analysed literature.

Design/methodology/approach
The researchers searched the Scopus database to collect and assess the literature on the topic. The paper used six applications such as Biblioshiny, VosViewer, Python, MS Access and Excel and Endnote to collect and analyse the literature.

Findings
It is found that European countries such as the USA, the UK and Germany took the lead in terms of publishing and impact in the area but the USA stood first with 90 publications and 1,720 citations in this connection. Likewise, the organization “Rheinisch-Westfälische Technische Hochschule Aachen” scored the top position regarding publishing, but Open AI remained on top for getting the highest citations (1,384). Apropos, the author “Choi, Y” produced the highest number of publications. The research also shares the collaborative patterns, top journals and publications in the area, as well as the top-used keywords on the topic.

Originality/value
To the best of the authors’ knowledge, this is the first study that shares a bibliometric analysis of literature published on GPT and ChatGPT. The research not only fills the research gap on the topic but also shares implications for relevant stakeholders and future research directions for future researchers.
Brand avatar present or absent? Investigate brand avatar and consumer forgiveness in public apology
Authors: Wang Xueying , Zhang Yuexian 
Published: May 2024

PurposeThe rising occurrence of digitally driven public consumer complaints has made it necessary for enterprises to obtain consumer forgiveness. However, existing research has provided little understanding regarding how to obtain consumer forgiveness effectively. Thus, the present study examined how brand avatars can improve consumer forgiveness in the context of public apology.Design/methodology/approachThis study tested the mechanism of a brand avatar on consumer forgiveness using three studies. Specifically, we explored the direct and mediating effect of empathy toward a brand (Study 1); we identified the moderating mediating effect of humorous responses (Study 2) and product type (Study 3). Data for these studies were collected on Credamo. We analyzed the data using SPSS (26.0) for the primary analysis and PROCESS (3.5) for the mediating and moderating mediating analysis.FindingsThe results indicate that brand avatars enhance consumer forgiveness. Moreover, empathy toward a brand plays a mediating role in the effect of brand avatars on consumer forgiveness. Additionally, when a humorous response is present, a brand avatar can enhance customer forgiveness through empathy toward that brand. Compared to utilitarian products, hedonic products can also increase the impact of a brand avatar on empathy toward the brand, thus enhancing consumers' forgiveness.Originality/valueFrom the perspective of emotion, this study explored the impact of brand avatars on consumer forgiveness via empathy toward a brand. It augments the research on brand avatars and consumer forgiveness. The study also verified the moderating mediating effect of humor response and product type while expanding the brand avatar research boundary.
Does Medicare Support Multidisciplinary Teams Working to the Top of Their Ticket?
Authors: Spinks Jean , Nancarrow Susan , McAvoy Sue , Nissen Lisa 
Published: May 2024

AbstractThe health landscape has changed enormously since the introduction of Medicare 40 years ago. Not only have population health needs changed, the provision of health care has also evolved. A wider range of health practitioners with enhanced skills and competencies are ready and able to provide high‐quality primary health care. However, expecting the funding model introduced 40 years ago to be fit for purpose to support this expanded workforce may be unrealistic. Whilst optimising person‐centred team care might be the vision, currently missing is the systems thinking approach required to realise the synergistic benefits of health care teams.
PREFIGURING PRAGMATICALLY? Prefigurative Politics and the Constellation of People Power Strategies for Winning Affordable Housing in Cape Town
Authors: Tattersall Amanda , Iveson Kurt 
Published: May 2024

AbstractThis article contributes to ongoing discussions about the practice of prefigurative politics by urban social movements, and the relationship between prefiguration and other political practices. We argue that urban social movements can deploy prefigurative power in combination with other political strategies with which it is often contrasted and opposed. To demonstrate, we explore Cape Town's Reclaim the City movement that occupied several inner‐city buildings to create affordable housing for low‐wage Black communities—prefiguring the kind of affordable housing that they were demanding. They developed this strategy iteratively after having tried to play by the rules through litigation and mobilize through protest. When those approaches failed to shift decision makers, they tried to prefigure their goal for housing through occupation. Prefiguration offered distinctive strategic advantages: it helped demonstrate that affordable housing was possible and provided direct relief for people facing housing stress. These advantages not only engaged new participants but contributed to new affordable housing commitments from the City of Cape Town and the courts. We show how movement participants understood their prefigurative occupation as part of a constellation of people power strategies and suggest that this points towards the potential for prefiguration to be deployed pragmatically as well as ideologically by urban social movements.