bluuebunny/crossref_metadata_2025_split huggingface dataset:
Local value creation for developing business relationships: An SME case study in the pasta industry
Authors: Runfola Andrea , Monteverde Giulia , Picciotti Antonio 
Published: April 2024

AbstractDrawing on the market-as-network approach from the Industrial Marketing and Purchasing (IMP) Group, this paper explores how small and medium-sized companies can leverage their network to become network orchestrators, co-creating value locally and developing business relationships. Specifically, the paper addresses the following research questions: RQ1) How can SMEs act as network orchestrators for local value co-creation? RQ2) How can SMEs leverage local value to develop business relationships? Methodologically, the industrial network theory is applied to an exploratory and single case study of an Italian food company in the pasta sector, Fabianelli. This enterprise boasts a historical tradition firmly linked to its origins and a solid attachment to the Tuscany region where it is located. The paper identifies specific actors, resources, and activities defining a company’s network orchestrator role. Further, it analyzes the value co-created locally to discuss four strategies used by Fabianelli to develop relationships with national and international actors.
Surface topography prediction of slider races using formed grinding wheel shape and material removal mechanism
Authors: Kang Mingxia , Hua Dezheng , Li Yongbo , Królczyk Grzegorz M. , Liu Xinhua , Gupta Munish Kumar , Królczyk J. B. , Li Z. 
Published: April 2024

AbstractCompared with the roughness, the three-dimensional (3D) topography parameters, surface microstructure geometric characteristics and other information can more fully evaluate the grinding quality of the slider raceway surface. In this paper, based on the 3D topography model of the abrasive particle distribution on the surface of the formed grinding wheel, the material removal mechanism between the abrasive particle and the raceway surface is analyzed. With the undeformed chip thickness distribution model as the intermediate variable, the 3D topography model of the slider raceway surface is established, and the model verification is carried out from the roughness and the geometric characteristics of the surface microstructure, respectively. At the same time, the surface microstructure is extracted from the topography model, and the effects of different grinding process parameters on the geometric characteristics such as the height to width ratio, depth to width ratio and distribution density of groove, convex peak and peak valley structures are studied. Results are shown that AS,TH increase from [0.05 0.6 μm] to [0.25 0.8 μm] and FGH grows from [0.11 1.05 μm] to [0.5 1.61 μm] when the grinding depth rises from 1 μm to 4 μm. AS, TH are firstly decreased from [0.17 0.61 μm] to [0.08 0.52 μm] and then increased to [0.26 0.78 μm], and the FGH declines from [0.34 1.01 μm] to [0.16 0.86 μm] and then increases to [0.51 1.38 μm] with the feeding speed is in [25, 28 m/min]. In addition, in the range of grinding wheel linear velocity [28, 34 m/s], the AS,TH decreases from [0.19 0.81 μm] to [0.1 0.55 μm] and the FGH decreases from [0.55 1.6 μm] to [0.2 1.1 μm]. This can prepare for the subsequent research on the impact of the topography characteristics on the friction coefficient and wear amount of the slider raceway surface.
Well-Posedness of the Two-Component Fornberg–Whitham System in Besov Spaces
Authors: Dutta Prerona 
Published: April 2024

AbstractThe present paper establishes well-posedness for the two-component Fornberg–Whitham system in Besov spaces. First the existence and uniqueness of its solution is proved, then it is shown that the corresponding data-to-solution map is continuous, provided the initial data belong to Besov spaces.
“Hot Forests”: Spatial Concentration of Forest “Pyro-Terrorism” in Israel
Authors: Perry Simon , Amram Shai 
Published: April 2024

AbstractOne of the areas in terrorism research that has not been adequately examined is the geographic concentration of pyro-terrorism (PT) attacks. The literature related to the geographical distribution of terror generally focuses on macro-places (continents, countries and regions) and micro-places – “hot spots”. However, to our knowledge, the geographical distribution of terror in forests has yet to be studied. The findings of “hot spots” studies have great relevance for law enforcement practitioners. This study examines the spatial characteristics of forest PT and whether there is a concentration of PT attacks in a limited number of “hot forests” that are stable over time. This study examined the entire population of suspected forest PT in Israel between 2008 and 2022 (excluding 2016), totalling 2,297 attacks. The research revealed high spatial clustering of forest PT attacks concentrated in specific “hot forests” and that they were stable over time. In conclusion, the concentration of PT attacks calls for a specialized counterterrorism response, equivalent to “hot spots policing”, based on the characteristics of potential terrorist hot forests.
FIRST EIGENVALUE CHARACTERISATION OF CLIFFORD HYPERSURFACES AND VERONESE SURFACES
Authors: WU PEIYI 
Published: April 2024

AbstractWe give a sharp estimate for the first eigenvalue of the Schrödinger operator
$L:=-\Delta -\sigma $
which is defined on the closed minimal submanifold
$M^{n}$
in the unit sphere
$\mathbb {S}^{n+m}$
, where
$\sigma $
is the square norm of the second fundamental form.
The Rushdie Affair and the Politics of Multicultural Britain
Authors: Connell Kieran 
Published: April 2024

AbstractIt is more than thirty years since Ayatollah Khomeini, the supreme leader of Iran, issued a fatwa (religious decree) calling for the execution of the British-Indian novelist Salman Rushdie, whose third novel, The Satanic Verses, was published in 1988. But the ‘Rushdie Affair’ has yet to be subject to a sustained analysis by historians. Journalists and political scientists continue to focus on the fatwa, despite the fact the protests against the novel in Britain – where The Satanic Verses is primarily set – predated Khomeini’s decree by two months. This article fills this lacuna by shifting attention onto the emergence of the campaign against The Satanic Verses in Britain and in Bradford especially, where a copy of Rushdie’s ‘blasphemous’ novel was infamously burnt by Muslim protestors. It shows how an earlier set of campaigns fought in Bradford by Muslim activists paved the way for the city to become a key site of protest against both Rushdie and his novel. The protests that greeted The Satanic Verses were shaped by the contradictory nature of Britain’s emergence as a multicultural society, I argue, and the political complexities thrown up by the hybridized milieu Rushdie had sought to use his fiction to evoke.
Late-life divorce and familyhood interplaying: a familial and dyadic perspective
Authors: Koren Chaya , Cohen Yafit , Egert Michal , Demeter Naor 
Published: April 2024

Abstract
Late-life divorce is a growing phenomenon in the Western world, likely to expand due to increasing expectancy and changes in marital and family values. However, existing research on divorce and its consequences for offspring focuses on young and middle-aged adults, analysing individual rather than familial/dyadic perspectives. Accordingly, our study employs a holistic perspective on the family unit following late-life divorce which is especially relevant to societies that value familism as an essential element in individuals' lives. Coincidingly, the term familyhood expresses an atmosphere of closeness and unity among family members and is a commonly used expression in Israel. Using family systems as a framework, our aim was to examine how, if at all, familyhood is experienced after divorce considering how it was experienced prior to divorce from a long-term marriage in Israel. Semi-structured, in-depth qualitative interviews (N = 72) were conducted separately with divorcees aged 60–81 who divorced at age 56–68 (N = 44), and with their adult children aged 19–40 at the time of their parents' divorce (N = 28). Interviews were given thematic analysis and dyadic qualitative analysis. The findings reveal the meaningfulness of familyhood following late-life divorce via a fourfold typology of familyhood continuity/change experienced as present or lacking, before or after divorce. The typology addresses key elements of when, where, by whom and how familyhood is reconstructed, along with strategies to maintain familyhood. Paradoxes inherent in the intersection of divorce and familyhood, discussed within the Israeli sociocultural context, are located between self-determination and familism. Implications are presented.
Cardiac resternotomy after cardiac surgery in kids: CRACK the chest
Authors: Shah Jui , Sefton Ashley , Dentel John , Tilford Bradley , Cashen Katherine 
Published: April 2024

AbstractObjective:Emergent resuscitation of postoperative paediatric cardiac surgical patients requires specialised skills and multidisciplinary teamwork. Bedside resternotomy is a rare but life-saving procedure and few studies focus on ways to prepare providers and improve performance. We created a multidisciplinary educational intervention that addressed teamwork and technical skills. We aimed to evaluate the efficiency of the intervention to decrease time to perform critical tasks and improve caregiver comfort.Methods:A simulation-based, in situ resternotomy educational intervention was implemented. Pre-intervention data were collected. Educational aids were used weekly during day and night nursing huddles over a three-month period. All ICU charge nurses had separate educational sessions with study personnel and were required to demonstrate competency in all the critical tasks. Post-intervention simulations were performed after intervention and at 6 months and post-intervention surveys were performed.Results:A total of 186 providers participated in the intervention. There was a decrease in time to obtain defibrillator, setup resternotomy equipment and internal defibrillator paddles and deliver sedation and fluid (all p < 0.05). Time to escort family from the room and obtain blood was significantly decreased after intervention (p < 0.05). There was no difference in time to first dose of epinephrine, defibrillator pads on the patient, or time to call the cardiovascular surgeon or blood bank. Providers reported increased comfort in identifying equipment needed for resternotomy (p < 0.01) and setting up the internal defibrillator paddles (p < 0.01).Conclusions:Implementation of a novel educational intervention increased provider comfort and decreased time to perform critical tasks in an emergent resternotomy scenario.
The emergence of Gaza as a provincial intellectual centre during the Mamluk period
Authors: Amir Or 
Published: April 2024

AbstractDuring the Mamluk period (1260–1516), Gaza developed from a minor town into an important city in southern Bilād al-Shām, the capital of an administrative province. This prosperity was the product of substantial and continuous Mamluk investment in the town, the security and stability maintained by this regime, and Gaza's strategic location as the bridge connecting Egypt and Bilād al-Shām. This article will trace the concomitant development of Gaza as a provincial intellectual centre within this context. Combining narrative sources with epigraphic and material evidence, it will show how the growth of Gaza as an administrative centre instigated a flourishing—albeit modest—scholarly scene in the town, which, while strongly connected to and integrated with wider social and intellectual networks within the Sultanate, retained its unique character.
Bilinguals on the footbridge: the role of foreign-language proficiency in moral decision making
Authors: Teitelbaum Dorfman Federico , Kogan Boris , Barttfeld Pablo , García Adolfo M. 
Published: April 2024

Abstract
Socio-cognitive research on bilinguals points to a moral foreign-language effect (MFLE), with more utilitarian choices (e.g., sacrificing someone to save more people) for moral dilemmas presented in the second language (L2) relative to the first language. Yet, inconsistent results highlight the influence of subject-level variables, including a critical underexplored factor: L2 proficiency (L2p). Here we provide a systematic review of 57 bilingualism studies on moral dilemmas, showing that L2p rarely modulates responses to impersonal dilemmas, but it does impact personal dilemmas (with MFLEs proving consistent at intermediate L2p levels but unsystematic at high L2p levels). We propose an empirico-theoretical framework to conceptualize such patterns, highlighting the impact of L2p on four affective mediating factors: mental imagery, inhibitory control, prosocial behavior and numerical processing. Finally, we outline core challenges for the field. These insights open new avenues at the crossing of bilingualism and social cognition research.
Mechanism of phase condensation for chromosome architecture and function
Authors: Park Jeongveen , Kim Jeong-Jun , Ryu Je-Kyung 
Published: April 2024

AbstractChromosomal phase separation is involved in a broad spectrum of chromosome organization and functional processes. Nonetheless, the intricacy of this process has left its molecular mechanism unclear. Here, we introduce the principles governing phase separation and its connections to physiological roles in this context. Our primary focus is contrasting two phase separation mechanisms: self-association-induced phase separation (SIPS) and bridging-induced phase separation (BIPS). We provide a comprehensive discussion of the distinct features characterizing these mechanisms and offer illustrative examples that suggest their broad applicability. With a detailed understanding of these mechanisms, we explore their associations with nucleosomes and chromosomal biological functions. This comprehensive review contributes to the exploration of uncharted territory in the intricate interplay between chromosome architecture and function.
3C methods in cancer research: recent advances and future prospects
Authors: Yoon Insoo , Kim Uijin , Jung Kyung Oh , Song Yousuk , Park Taesoo , Lee Dong-Sung 
Published: April 2024

AbstractIn recent years, Hi-C technology has revolutionized cancer research by elucidating the mystery of three-dimensional chromatin organization and its role in gene regulation. This paper explored the impact of Hi-C advancements on cancer research by delving into high-resolution techniques, such as chromatin loops, structural variants, haplotype phasing, and extrachromosomal DNA (ecDNA). Distant regulatory elements interact with their target genes through chromatin loops. Structural variants contribute to the development and progression of cancer. Haplotype phasing is crucial for understanding allele-specific genomic rearrangements and somatic clonal evolution in cancer. The role of ecDNA in driving oncogene amplification and drug resistance in cancer cells has also been revealed. These innovations offer a deeper understanding of cancer biology and the potential for personalized therapies. Despite these advancements, challenges, such as the accurate mapping of repetitive sequences and precise identification of structural variants, persist. Integrating Hi-C with multiomics data is key to overcoming these challenges and comprehensively understanding complex cancer genomes. Thus, Hi-C is a powerful tool for guiding precision medicine in cancer research and treatment.
Resolution of tonic concentrations of highly similar neurotransmitters using voltammetry and deep learning
Authors: Goyal Abhinav , Yuen Jason , Sinicrope Stephen , Winter Bailey , Randall Lindsey , Rusheen Aaron E. , Blaha Charles D. , Bennet Kevin E. , Lee Kendall H. , Shin Hojin , Oh Yoonbae 
Published: April 2024

AbstractWith advances in our understanding regarding the neurochemical underpinnings of neurological and psychiatric diseases, there is an increased demand for advanced computational methods for neurochemical analysis. Despite having a variety of techniques for measuring tonic extracellular concentrations of neurotransmitters, including voltammetry, enzyme-based sensors, amperometry, and in vivo microdialysis, there is currently no means to resolve concentrations of structurally similar neurotransmitters from mixtures in the in vivo environment with high spatiotemporal resolution and limited tissue damage. Since a variety of research and clinical investigations involve brain regions containing electrochemically similar monoamines, such as dopamine and norepinephrine, developing a model to resolve the respective contributions of these neurotransmitters is of vital importance. Here we have developed a deep learning network, DiscrimNet, a convolutional autoencoder capable of accurately predicting individual tonic concentrations of dopamine, norepinephrine, and serotonin from both in vitro mixtures and the in vivo environment in anesthetized rats, measured using voltammetry. The architecture of DiscrimNet is described, and its ability to accurately predict in vitro and unseen in vivo concentrations is shown to vastly outperform a variety of shallow learning algorithms previously used for neurotransmitter discrimination. DiscrimNet is shown to generalize well to data captured from electrodes unseen during model training, eliminating the need to retrain the model for each new electrode. DiscrimNet is also shown to accurately predict the expected changes in dopamine and serotonin after cocaine and oxycodone administration in anesthetized rats in vivo. DiscrimNet therefore offers an exciting new method for real-time resolution of in vivo voltammetric signals into component neurotransmitters.
Non-canonical deubiquitination of OTUB1 induces IFNγ-mediated cell cycle arrest via regulation of p27 stability
Authors: Lee Seul Gi , Woo Seon Min , Seo Seung Un , Lee Hyun Shik , Kim Sang Hyun , Chang Young-Chae , Cho Hyo Je , Yook Simmyung , Nam Ju-Ock , Kwon Taeg Kyu 
Published: April 2024

AbstractThe deubiquitinase OTUB1, implicated as a potential oncogene in various tumors, lacks clarity in its regulatory mechanism in tumor progression. Our study investigated the effects and underlying mechanisms of OTUB1 on the breast cancer cell cycle and proliferation in IFNγ stimulation. Loss of OTUB1 abrogated IFNγ-induced cell cycle arrest by regulating p27 protein expression, whereas OTUB1 overexpression significantly enhanced p27 expression even without IFNγ treatment. Tyr26 phosphorylation residue of OTUB1 directly bound to p27, modulating its post-translational expression. Furthermore, we identified crucial lysine residues (K134, K153, and K163) for p27 ubiquitination. Src downregulation reduced OTUB1 and p27 expression, suggesting that IFNγ-induced cell cycle arrest is mediated by the Src-OTUB1-p27 signaling pathway. Our findings highlight the pivotal role of OTUB1 in IFNγ-induced p27 expression and cell cycle arrest, offering therapeutic implications.
Contrast enhanced ultrasound for traumatic spinal cord injury: an overview of current and future applications
Authors: Saway Brian Fabian , Courtney James , Barley Jessica , Frankel Bruce , Hofstetter Christoph , Kalhorn Stephen 
Published: April 2024

Abstract
Study design
Systematic review.

Objective
Contrast-enhanced ultrasound (CEUS) is an imaging modality that has only recently seen neurosurgical application. CEUS uses inert microbubbles to intraoperatively visualize vasculature and perfusion of the brain and spinal cord in real time. Observation and augmentation of spinal cord perfusion is vital component of the management of traumatic spinal cord injury, yet there are limited imaging modalities to evaluate spinal cord perfusion. CEUS provides an intraoperative imaging tool to evaluate spinal cord perfusion in real time. The objective of this review is to evaluate the current literature on the various applications and benefits of CEUS in traumatic spinal cord injury.

Setting
South Carolina, USA.

Methods
This review was written according to the PRISMA 2020 guidelines.

Results
143 articles were found in our literature search, with 46 of them being unique. After excluding articles for relevance to CEUS and spinal cord injury, we were left with 10 papers. Studies in animal models have shown CEUS to be an effective non-invasive imaging modality that can detect perfusion changes of injured spinal cords in real time.

Conclusion
This imaging modality can provide object perfusion data of the nidus of injury, surrounding penumbra and healthy neural tissue in a traumatized spinal cord. Investigation in its use in humans is ongoing and remains promising to be an effective diagnostic and prognostic tool for those suffering from spinal cord injury.
First-line oxaliplatin-based chemotherapy and nivolumab for metastatic microsatellite-stable colorectal cancer—the randomised METIMMOX trial
Authors: Ree Anne Hansen , Šaltytė Benth Jūratė , Hamre Hanne M. , Kersten Christian , Hofsli Eva , Guren Marianne G. , Sorbye Halfdan , Johansen Christin , Negård Anne , Bjørnetrø Tonje , Nilsen Hilde L. , Berg Jens P. , Flatmark Kjersti , Meltzer Sebastian 
Published: April 2024

Abstract
Background
We evaluated first-line treatment of metastatic microsatellite-stable colorectal cancer with short-course oxaliplatin-based chemotherapy alternating with immune checkpoint blockade.

Methods
Patients were randomly assigned to chemotherapy (the FLOX regimen; control group) or alternating two cycles each of FLOX and nivolumab (experimental group). Radiographic response assessment was done every eight weeks with progression-free survival (PFS) as the primary endpoint. Cox proportional-hazards regression models estimated associations between PFS and relevant variables. A post hoc analysis explored C-reactive protein as signal of responsiveness to immune checkpoint blockade.

Results
Eighty patients were randomised and 38 in each group received treatment. PFS was comparable—control group: median 9.2 months (95% confidence interval (CI), 6.3–12.7); experimental group: median 9.2 months (95% CI, 4.5–15.0). The adjusted Cox model revealed that experimental-group subjects aged ≥60 had significantly lowered progression risk (p = 0.021) with hazard ratio 0.17 (95% CI, 0.04–0.76). Experimental-group patients with C-reactive protein <5.0 mg/L when starting nivolumab (n = 17) reached median PFS 15.8 months (95% CI, 7.8–23.7). One-sixth of experimental-group cases (all KRAS/BRAF-mutant) achieved complete response.

Conclusions
The investigational regimen did not improve the primary outcome for the intention-to-treat population but might benefit small subgroups of patients with previously untreated, metastatic microsatellite-stable colorectal cancer.

Trial registration
ClinicalTrials.gov number, NCT03388190 (02/01/2018).
Emerging roles of circular RNAs in nasopharyngeal carcinoma: functions and implications
Authors: Ma Aiyu , Yang Yuzhong , Lu Lu , Zhang Yan , Zhang Xuemei , Zheng Jinhua , Zheng Xiang 
Published: April 2024

AbstractNasopharyngeal carcinoma (NPC) is a distinct malignancy primarily prevalent in Southern China and Southeast Asia. Circular RNAs (circRNAs), a class of non-coding RNAs, are evolutionarily conserved and exhibit remarkable stability. Their dysregulation has been observed in various cancers, including NPC. In this review, we investigate the pivotal role of circRNAs in NPC, focusing specifically on their involvement in tumor proliferation, apoptosis, metastasis, angiogenesis, stemness, metabolism, and the tumor microenvironment. We highlight the diagnostic and prognostic potential of circRNAs in NPC, emphasizing their utility as biomarkers for early detection, disease monitoring, and prediction of treatment outcomes. Additionally, we explore the therapeutic implications of circRNAs in NPC, highlighting their potential for targeted therapies.