bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study on the magnetoelectric effect, ferroelectric and optical investigation of (1−x) BCT + x NZLFO multiferroic composite
Authors: Rahman M. Atikur , Hasan Zahid , Rouf Hasan Khaled , Alam M. Khurshed , Hossain A. K. M. Akther , Khan M. N. I. , Mohammad M. R. , Alodhayb Abdullah , Mohammad Saikh , Haldhar Rajesh , Hossain M. Khalid 
Published: April 2024

AbstractThis study investigates the magnetoelectric coupling effect in dual‐phase multiferroic composites prepared using a solid‐state reaction method. The composites were fabricated with the formula (1−x)Ba₀.₇₇Ca₀.₂₃TiO₃(BCT) + xNi₀.₆Zn₀.₂₅La₀.₁₅Fe₂O₄(NZLFO), where x varied from 0% to 100% in 10% increments. Ca‐doped BaTiO₃ served as the ferroelectric phase, while La‐doped Ni–Zn ferrite acted as the ferromagnetic phase. The effects of varying ferrite content (x) on structural, optical, ferroelectric, electrical, and magnetoelectric properties were comprehensively analyzed. X‐ray diffraction (XRD) with Rietveld refinement revealed a spinel cubic structure for the ferrite phases and a tetragonal structure for the perovskite phases. The study observed a moderate influence of ferrite concentration on the lattice parameters of BCT and an opposing effect on the lattice parameters of NZLFO. Optical measurements indicated higher light absorption in the visible range compared to the UV region and wide optical bandgap. Magnetic properties, characterized by saturation magnetization, exhibited a dependence on temperature, with a Curie temperature (Tc) of 700 K. Electrical resistivity displayed a maximum at x = 50% and remained constant at high frequencies. The study also confirmed the presence of electric polarization induced by a magnetic field, with the highest magnetoelectric coefficient observed at x = 10%. These findings demonstrate the successful fabrication of dual‐phase multiferroic composites with tunable properties through controlled ferrite content. The observed magnetoelectric coupling suggests potential applications in multifunctional devices.
The multifaceted life of macrophages in white adipose tissue: Immune shift couples with metabolic switch
Authors: Wang Qun , Hartig Sean M. , Ballantyne Christie M. , Wu Huaizhu 
Published: April 2024

SummaryWhite adipose tissue (WAT) is a vital endocrine organ that regulates energy balance and metabolic homeostasis. In addition to fat cells, WAT harbors macrophages with distinct phenotypes that play crucial roles in immunity and metabolism. Nutrient demands cause macrophages to accumulate in WAT niches, where they remodel the microenvironment and produce beneficial or detrimental effects on systemic metabolism. Given the abundance of macrophages in WAT, this review summarizes the heterogeneity of WAT macrophages in physiological and pathological conditions, including their alterations in quantity, phenotypes, characteristics, and functions during WAT growth and development, as well as healthy or unhealthy expansion. We will discuss the interactions of macrophages with other cell partners in WAT including adipose stem cells, adipocytes, and T cells in the context of various microenvironment niches in lean or obese condition. Finally, we highlight how adipose tissue macrophages merge immunity and metabolic changes to govern energy balance for the organism.
Exosomal HSPB1, interacting with FUS protein, suppresses hypoxia‐induced ferroptosis in pancreatic cancer by stabilizing Nrf2 mRNA and repressing P450
Authors: Zhang Lun , Yang Liuxu , Du Keyuan 
Published: April 2024

AbstractFerroptosis is a new type of programmed cell death, which has been involved in the progression of tumours. However, the regulatory network of ferroptosis in pancreatic cancer is still largely unknown. Here, using datasets from GEO and TCGA, we screened HSPB1, related to the P450 monooxygenase signalling, a fuel of ferroptosis, to be a candidate gene for regulating pancreatic cancer cell ferroptosis. We found that HSPB1 was enriched in the exosomes derived from human pancreatic cancer cell lines SW1990 and Panc‐1. Then, hypoxic SW1990 cells were incubated with exosomes alone or together with HSPB1 siRNA (si‐HSPB1), and we observed that exosomes promoted cell proliferation and invasion and suppressed ferroptosis, which was reversed by si‐HSPB1. Moreover, we found a potential binding affinity between HSPB1 and FUS, verified their protein interaction by using dual‐colour fluorescence colocalization and co‐IP assays, and demonstrated the promoting effect of FUS on oxidative stress and ferroptosis in hypoxic SW1990 cells. Subsequently, FUS was demonstrated to bind with and stabilize the mRNA of Nrf2, a famous anti‐ferroptosis gene that negatively regulates the level of P450. Furthermore, overexpressing FUS and activating the Nrf2/HO‐1 pathway (using NK‐252) both reversed the inhibitory effect of si‐HSPB1 on exosome functions. Finally, our in vivo studies showed that exosome administration promote tumour growth in nude mice of xenotransplantation, which was able to be eliminated by knockdown of HSPB1. In conclusion, exosomal HSPB1 interacts with the RNA binding protein FUS and decreases FUS‐mediated stability of Nrf2 mRNA, thus suppressing hypoxia‐induced ferroptosis in pancreatic cancer.
Retinoids in the treatment of photoageing: A histological study of topical retinoid efficacy in black skin
Authors: Halai P. , Kiss O. , Wang R. , Chien A. L. , Kang S. , O'Connor C. , Bell M. , Griffiths C. E. M. , Watson R. E. B. , Langton A. K. 
Published: April 2024

AbstractBackgroundPhotoageing describes complex cutaneous changes that occur due to chronic exposure to solar ultraviolet radiation (UVR). The ‘gold standard’ for the treatment of photoaged white skin is all‐trans retinoic acid (ATRA); however, cosmetic retinol (ROL) has also proven efficacious. Recent work has identified that black skin is susceptible to photoageing, characterized by disintegration of fibrillin‐rich microfibrils (FRMs) at the dermal–epidermal junction (DEJ). However, the impact of topical retinoids for repair of black skin has not been well investigated.ObjectivesTo determine the potential of retinoids to repair photoaged black skin.MethodsAn exploratory intervention study was performed using an in vivo, short‐term patch test protocol. Healthy but photoaged black volunteers (>45 years) were recruited to the study, and participant extensor forearms were occluded with either 0.025% ATRA (n = 6; 4‐day application due to irritancy) or ROL (12‐day treatment protocol for a cosmetic) at concentrations of 0.3% (n = 6) or 1% (n = 6). Punch biopsies from occluded but untreated control sites and retinoid‐treated sites were processed for histological analyses of epidermal characteristics, melanin distribution and dermal remodelling.ResultsTreatment with ATRA and ROL induced significant acanthosis (all p < 0.001) accompanied by a significant increase in keratinocyte proliferation (Ki67; all p < 0.01), dispersal of epidermal melanin and restoration of the FRMs at the DEJ (all p < 0.01), compared to untreated control.ConclusionsThis study confirms that topical ATRA has utility for the repair of photoaged black skin and that ROL induces comparable effects on epidermal and dermal remodelling, albeit over a longer timeframe. The effects of topical retinoids on black photoaged skin are similar to those reported for white photoaged skin and suggest conserved biology in relation to repair of UVR‐induced damage. Further investigation of topical retinoid efficacy in daily use is warranted for black skin.
Inshore and offshore marine migration pathways of Atlantic salmon post‐smolts from multiple rivers in Scotland, England, Northern Ireland, and Ireland
Authors: Rodger Jessica R. , Lilly Jessie , Honkanen Hannele M. , del Villar Diego , Kennedy Richard , Maoiléidigh Niall Ó. , Boylan Patrick , Rosell Robert , Morris David J. , O'Neill Ross , Waters Catherine , Cotter Deirdre , Wilkie Lorna , Barkley Andrea , Green Amy , Beck Samantha V. , Ribbens Jamie , Henderson Jim , Parke Debbie , Kettle‐White Alan , Ballantyne Lucy , Marshall Shona , Hopper Paul , Gauld Niall , Godfrey Jason D. , Chapman Lauren E. , Thorburn James , Drumm Alan , Whoriskey Fred , Shields Brian , Ramsden Philip , Barry James , Millane Michael , Roche William , Armstrong John D. , Wells Alan , Walton Silas , Fletcher Melanie , Bailey David M. , Whyte Bill , McGill Ross , Bilsby Mark , Whelan Ken , Bean Colin W. , Adams Colin E. 
Published: April 2024

AbstractThe migratory behavior of Atlantic salmon (Salmo salar) post‐smolts in coastal waters is poorly understood. In this collaborative study, 1914 smolts, from 25 rivers, in four countries were tagged with acoustic transmitters during a single seasonal migration. In total, 1105 post‐smolts entered the marine study areas and 438 (39.6%) were detected on a network of 414 marine acoustic receivers and an autonomous underwater vehicle. Migration pathways (defined as the shortest distance between two detections) of up to 575 km and over 100 days at sea were described for all 25 populations. Post‐smolts from different rivers, as well as individuals from the same river, used different pathways in coastal waters. Although difficult to generalize to all rivers, at least during the year of this study, no tagged post‐smolts from rivers draining into the Irish Sea were detected entering the areas of sea between the Hebrides and mainland Scotland, which is associated with a high density of finfish aquaculture. An important outcome of this study is that a high proportion of post‐smolts crossed through multiple legislative jurisdictions and boundaries during their migration. This study provides the basis for spatially explicit assessment of the impact risk of coastal pressures on salmon during their first migration to sea.
Characterisation and correction of polarisation effects in fluorescently labelled fibres
Authors: Aggarwal Nandini , Marsh Richard , Marcotti Stefania , Shaw Tanya J , Stramer Brian , Cox Susan , Culley Siân 
Published: April 2024

SummaryMany biological structures take the form of fibres and filaments, and quantitative analysis of fibre organisation is important for understanding their functions in both normal physiological conditions and disease. In order to visualise these structures, fibres can be fluorescently labelled and imaged, with specialised image analysis methods available for quantifying the degree and strength of fibre alignment. Here we show that fluorescently labelled fibres can display polarised emission, with the strength of this effect varying depending on structure and fluorophore identity. This can bias automated analysis of fibre alignment and mask the true underlying structural organisation. We present a method for quantifying and correcting these polarisation effects without requiring polarisation‐resolved microscopy and demonstrate its efficacy when applied to images of fluorescently labelled collagen gels, allowing for more reliable characterisation of fibre microarchitecture.
AEBP1 upregulation contributes to cervical cancer progression by facilitating cell proliferation, migration, and invasion
Authors: Liu Songjun , Gu Yanpin , Shi Yin , Yu Shuqian , Li Wu , Lv Wen 
Published: April 2024

AbstractBackgroundAberrant expression of adipocyte enhancer‐binding protein 1 (AEBP1) has been demonstrated to be involved in the tumorigenesis and progression of numerous cancers. This study was aimed to investigate the mechanism of AEBP1 in the development of cervical cancer.MethodsThe expression of AEBP1 in cervical cancer was assessed by immunohistochemistry. The function of AEBP1 on cell proliferation, migration, and invasion was determined by methyl thiazolyl tetrazolium assay, colony formation, and transwell assay. The activation of related signaling pathway was determined by western blot. The bioinformatics analysis was performed by Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis.ResultsHigher protein expression of AEBP1 was observed in patients with cervical cancer. Overexpressed AEBP1 promoted cell proliferation, migration, and invasion abilities in cervical cancer cells. Moreover, the research manifested that AEBP1 activated the phosphorylation of STAT3. GO and KEGG analysis showed that genes positively related to AEBP1 were highly enriched in functions like epithelial cell proliferation, muscle cell migration, myoblast migration, smooth muscle tissue development, ECM–receptor interaction, transcriptional misregulation in cancer, and proteoglycans in cancer. While genes negatively related to AEBP1 were associated with immunity, including inflammatory response, external‐stimulus response, neutrophil, granulocyte, and macrophage chemotaxis.ConclusionsThis study suggested that AEBP1 acts as an oncogened and might be a potential therapeutic target for the treatment of cervical cancer.
Provenance constraints on the Late Triassic ejecta layer from Churchwood Quarry, SW England: An impactite suite from Manicouagan
Authors: McGregor Maree , Spray John G. , McFarlane Christopher R. M. 
Published: April 2024

AbstractIn situ LA‐ICP‐MS/MS U‐Pb and Rb‐Sr geochronology combined with geochemical analysis and electron microscopy have been performed on ejecta components sampled from the Mid‐to‐Late Triassic Mercia Mudstone Group at Churchwood Quarry, SW England. The layer comprises altered impact spherules, melt‐rich and fragment‐rich accreted grain clusters (AGCs), along with shocked mineral phases. Late Triassic ages are obtained: a U‐Pb age of 219 ± 72 Ma from variably shock‐metamorphosed apatite and a Rb‐Sr age of 213 ± 31 Ma from melt‐rich AGCs. A post‐depositional U‐Pb age of 200 ± 7.5 Ma obtained from the carbonate host matrix correlates with an early Jurassic dolomitization event associated with regional marine transgression. Several links to the Manicouagan impact structure, Canada, are identified that complement previous provenance studies: (1) rare earth element compositions of impact spherules and melt‐rich AGCs match those of the Manicouagan impact melt sheet; (2) the preservation of Archean and Paleo‐ to Neoproterozoic target rock U‐Pb ages in zircon and apatite match those recorded within Manicouagan basement lithologies; and (3) impact spherules and melt‐rich AGCs record initial 87Sr/86Sr compositions that overlap with those of the Manicouagan impact melt sheet and the target rocks involved in their generation.
Synthesizing environmental, epidemiological and vector and parasite genetic data to assist decision making for disease elimination
Authors: Shrestha Himal , McCulloch Karen , Chisholm Rebecca H. , Armoo Samuel K. , Veriegh Francis , Sirwani Neha , Crawford Katie E. , Osei‐Atweneboana Mike Y. , Grant Warwick N. , Hedtke Shannon M. 
Published: April 2024

AbstractWe present a framework for identifying when conditions are favourable for transmission of vector‐borne diseases between communities by incorporating predicted disease prevalence mapping with landscape analysis of sociological, environmental and host/parasite genetic data. We explored the relationship between environmental features and gene flow of a filarial parasite of humans, Onchocerca volvulus, and its vector, blackflies in the genus Simulium. We generated a baseline microfilarial prevalence map from point estimates from 47 locations in the ecological transition separating the savannah and forest in Ghana, where transmission of O. volvulus persists despite onchocerciasis control efforts. We generated movement suitability maps based on environmental correlates with mitochondrial population structure of 164 parasites from 15 communities and 93 vectors from only four sampling sites, and compared these to the baseline prevalence map. Parasite genetic distance between sampling locations was significantly associated with elevation (r = .793, p = .005) and soil moisture (r = .507, p = .002), while vector genetic distance was associated with soil moisture (r = .788, p = .0417) and precipitation (r = .835, p = .0417). The correlation between baseline prevalence and parasite resistance surface maps was stronger than that between prevalence and vector resistance surface maps. The centre of the study area had high prevalence and suitability for parasite and vector gene flow, potentially contributing to persistent transmission and suggesting the importance of re‐evaluating transmission zone boundaries. With suitably dense sampling, this framework can help delineate transmission zones for onchocerciasis and would be translatable to other vector‐borne diseases.
Determinants of microbiome composition: Insights from free‐ranging hybrid zebras (Equus quagga × grevyi)
Authors: Abraham Joel O. , Lin Bing , Miller Audrey E. , Henry Lucas P. , Demmel Margaret Y. , Warungu Rosemary , Mwangi Margaret , Lobura Patrick M. , Pallares Luisa F. , Ayroles Julien F. , Pringle Robert M. , Rubenstein Daniel I. 
Published: April 2024

AbstractThe composition of mammalian gut microbiomes is highly conserved within species, yet the mechanisms by which microbiome composition is transmitted and maintained within lineages of wild animals remain unclear. Mutually compatible hypotheses exist, including that microbiome fidelity results from inherited dietary habits, shared environmental exposure, morphophysiological filtering and/or maternal effects. Interspecific hybrids are a promising system in which to interrogate the determinants of microbiome composition because hybrids can decouple traits and processes that are otherwise co‐inherited in their parent species. We used a population of free‐living hybrid zebras (Equus quagga × grevyi) in Kenya to evaluate the roles of these four mechanisms in regulating microbiome composition. We analysed faecal DNA for both the trnL‐P6 and the 16S rRNA V4 region to characterize the diets and microbiomes of the hybrid zebra and of their parent species, plains zebra (E. quagga) and Grevy's zebra (E. grevyi). We found that both diet and microbiome composition clustered by species, and that hybrid diets and microbiomes were largely nested within those of the maternal species, plains zebra. Hybrid microbiomes were less variable than those of either parent species where they co‐occurred. Diet and microbiome composition were strongly correlated, although the strength of this correlation varied between species. These patterns are most consistent with the maternal‐effects hypothesis, somewhat consistent with the diet hypothesis, and largely inconsistent with the environmental‐sourcing and morphophysiological‐filtering hypotheses. Maternal transmittance likely operates in conjunction with inherited feeding habits to conserve microbiome composition within species.
Epidemiological patterns of candidaemia: A comprehensive analysis over a decade
Authors: Ferngren Gordon , Yu David , Unalan‐Altintop Tugce , Dinnétz Patrik , Özenci Volkan 
Published: April 2024

AbstractBackgroundThe prevalence of fungal bloodstream infections (BSI), especially candidaemia, has been increasing globally during the last decades. Fungal diagnosis is still challenging due to the slow growth of fungal microorganisms and need for special expertise. Fungal polymicrobial infections further complicate the diagnosis and extend the time required. Epidemiological data are vital to generate effective empirical treatment strategies.ObjectivesThe overall aim of this project is to describe the epidemiology of monomicrobial candidaemia and polymicrobial BSI, both with mixed fungaemia and with mixed Candida/bacterial BSIs.MethodsWe conducted a single‐centre retrospective epidemiological study that encompasses 950,161 blood cultures during the years 2010 to 2020. The epidemiology of monomicrobial and polymicrobial candidaemia episodes were investigated from the electronic records.ResultsWe found that 1334 candidaemia episodes were identified belonging to 1144 individual patients during 2010 to 2020. Candida albicans was the most prevalent species detected in candidaemia patients, representing 57.7% of these episodes. Nakaseomyces (Candida) glabrata and Candida parapsilosis complex showed an increasing trend compared to previous studies, whereas Candida albicans demonstrated a decrease. 19.8% of these episodes were polymicrobial and 17% presented with mixed Candida/bacterial BSIs while 2.8% were mixed fungaemia. C. albicans and N. glabrata were the most common combination (51.4%) in mixed fungaemia episodes. Enterococcus and Lactobacillus spp. were the most common bacteria isolated in mixed Candida/bacterial BSIs.ConclusionsPolymicrobial growth with candidaemia is common, mostly being mixed Candida/bacterial BSIs. C. albicans was detected in more than half of all the candidaemia patients however showed a decreasing trend in time, whereas an increase is noteworthy in C. parapsilosis complex and N. glabrata.
A systematic review and meta‐analysis of the child‐level effects of family‐based interventions for the prevention of type 2 diabetes mellitus
Authors: Kurtzhals Mette , Bjerregaard Anne‐Louise , Hybschmann Jane , Müllertz Alberte Laura Oest , DeSilva Bianca , Elsborg Peter , Timm Anne , Petersen Therese Lockenwitz , Thygesen Lau Caspar , Kurtzhals Peter , Flensborg‐Madsen Trine , Bentsen Peter , Mygind Lærke 
Published: April 2024

SummaryAimsThe purpose of this systematic review and meta‐analysis was to investigate the effects of family‐based health promotion interventions on child‐level risk factors for type 2 diabetes in vulnerable families.MethodsThe Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) checklist for systematic reviews formed the methodological framework. CINAHL, Embase, MEDLINE, PsycINFO, and Web of Science were searched on January 12, 2024. The NTP‐OHAT Risk of Bias Assessment Tool was used to assess the risk of bias in the individual studies, and meta‐analyses were performed.ResultsThe 4723 studies were identified, and 55 studies met the inclusion criteria. Results showed significant effects on children's body mass index (mean difference [MD], −0.18, 95% CI [−0.33 to −0.03], p = 0.02), body fat percentage (MD, −2.00, 95% CI [−3.31 to −0.69], p = 0.003), daily activity (standardized mean difference [SMD], 0.23, 95% CI [0.01; 0.44], p = 0.04), physical activity self‐efficacy (SMD, 0.73, 95% CI [0.36 to 1.10], p < 0.01), intake of snacks (MD, −0.10, 95% CI [−0.17 to −0.04], p = 0.002), and sugar‐sweetened beverages (SMD, −0.21, 95% CI [−0.42 to −0.01], p = 0.04). Subgroup analyses suggested that interventions aiming to change child and parent behavior simultaneously have larger effect on fasting glucose and nutrition consumption, and that interventions longer than 26 weeks have larger effects on body composition and physical activity behavior than shorter interventions.