bluuebunny/crossref_metadata_2025_split huggingface dataset:
Teachers’ perceptions of teaching science with technology-enhanced self-regulated learning strategies through the DECODE model
Authors: Sui Chi-Jung , Yen Miao-Hsuan , Chang Chun-Yen 
Published: May 2024

AbstractThis study investigates the nuanced interplay between self-regulated learning (SRL) and technological pedagogical content knowledge (TPACK) among 192 Taiwanese voluntary pre-service and in-service teachers, seeking to understand how teachers perceive the integration of technology with SRL strategies in science education. The participants were recruited in workshops based on the DECODE model, which demonstrated a micro-unit of evolution incorporated in SRL strategies, involved them in co-reflected, and summarized what they had experienced in technology-enhanced environments. Participants self-reported measures of SRL and TPACK were subjected to path analysis. Results indicated that SRL positively influenced technological pedagogical knowledge (TPK) and technological content knowledge (TCK), subsequently fully mediating the relationship between SRL and TPACK; namely, TCK and TPK acted as mediatory factors. Furthermore, this study delved into teachers’ perceptions of technology-enhanced instruction and SRL through their responses in workshops. We identified five main themes through thematic analysis. The findings highlighted the pivotal role of technology in cultivating interactive learning environments, offering real-time feedback, and integrating multimedia into teaching. Teachers’ perceptions were expanded and refined after demonstrating a micro-unit with SRL strategies and subsequent reflective prompts. Participants acknowledged the imperative of teacher preparation in effectively leveraging technology and emphasized the crucial role of adaptive scaffolding in promoting SRL strategies. In summary, these findings present a viable path for augmenting teachers’ TPACK through SRL and provides insights into teachers’ perceptions of technology-enhanced SRL. The study has implication on the potential of the DECODE model and incorporation of SRL strategies for science educator’s professional development of TPACK.
‘I Can Kind of Flow How I Want to Flow’: Motivations and Perceived Contrasts of Providing Care in Home-Based Settings
Authors: Harmeyer Erin , Camp Brittany Wittenberg , Moon Catherine 
Published: May 2024

AbstractThe number of family child care (FCC) providers in the United States, or providers who are licensed, certified, or registered to provide care in their home, fell by nearly half between 2005 and 2017 (NCEQA, 2020a). This has implications for families who prefer FCC settings. Understanding providers’ motivations for starting their program may provide policymakers with information on how to better support providers drawn to this setting. Through interviews with 30 Black/bi-racial FCC providers, we found providers started their programs to support family/neighbors, to provide an alternative perceived to be safer than center-based programs, and to be in charge. In terms of differences, providers felt they had more control and that they could provide more individualized attention in home-based settings as compared to center-based settings. This research advances the study of why providers work in home-based programs, and how they perceive this work as different from center-based care, with implications for supporting the FCC workforce.
Theatre Hunger: An Underestimated ‘Scaling Up’ Problem
Authors: Downey Adrian 
Published: May 2024

AbstractThe proponents of ecological and enactive approaches (e-approaches) to cognitive science find common cause in rejecting representation as a core explanatory posit. In its stead, they suggest that cognitive scientists work with non-representational explanations that emphasise embodied interaction. The ‘scaling up’ objection to e-approaches says that, whilst their non-representational explanatory toolkit might well account for ‘basic’ cognitive capacities, it will founder when confronted with the ‘representation hunger’ of ‘higher’ cognition. Proponents of e-approaches tend to focus their attention upon the scaling up problem posed by truth-conditional language, with it being thought that non-perceptual experiences readily submit to a non-representational analysis. In this paper I argue that non-perceptual experiences possess an oft overlooked, non-linguistic kind of ‘representation hunger’— they hunger for a private mental space within which the representational function of standing-in for is performed. I contend that suchtheatre hungerposes serious difficulties for e-approaches which they are presently ill-placed to satiate. Hence, I conclude that the theatre hunger of non-perceptual experiences presents a much more serious problem for e-approaches than is often acknowledged.
Exploring Talent Management Practices and Corporate Social Responsibility in Finnish Companies
Authors: Cajander Niko , Reiman Arto 
Published: May 2024

AbstractThe contemporary work landscape is characterized by rapid change and many evolving challenges. Therefore, companies are in increasing need for acquiring fresh knowledge and skills and human capital is acknowledged being a crucial asset for success in business world. The challenge persists in attracting, retaining and managing skilled employees. Though, the importance of corporate social responsibility (CSR) in talent management has been recognized, still there remains a gap in understanding how talent management is integrated into CSR of companies, particularly at the multilevel investigation level. A directed content analysis method was employed on CSR reports of 25 major Finnish companies to explore key talent management practices at normative, strategic, and operational levels, as well as the integration of talent management components into CSR reports. Normative values such as diversity, equity, and inclusion were consistently emphasized in the reports. However, the translation of these values into practical implementation often yielded abstract strategic principles rather than clearly defined operational practices. The companies have placed over reliance on standardized reporting methods rather than providing comprehensive insights into talent management practices.
Selective allele stacking of a novel quantitative trait locus facilitates the enhancement of seed epicatechin content in soybean (Glycine max (L.) Merr.)
Authors: Park Sewon , Kwon Hakyung , Park Gyu Tae , Choi Jae Ah , Kim Moon Young , Park Soo-Kwon , Lee Suk-Ha 
Published: May 2024

Abstract(-)-Epicatechin (EC), a primary form of flavan-3ol and a building block of proanthocyanidins, has health benefits as it is a potent antioxidant. So far, no quantitative trait loci (QTLs) associated with EC have yet been identified in soybean. In this study, QTLs for EC and hilum color were identified in recombinant inbred lines (RILs) derived from the varieties Jinpung and IT109098 using high-resolution single nucleotide polymorphism linkage mapping. This revealed two major QTLs for EC content, qEC06 and qEC08. qEC06 spanned the Tawny (T) locus encoding flavonoid 3′-hydroxylase. qEC08, located near the Inhibitor (I) locus on Chr08, was also a major QTL for hilum color; however, allelic stacking of qEC08 and I revealed no relationship between I and EC content. RILs with IT109098 alleles at both qEC06 and qEC08 had higher EC content than other lines. These results will enable the production of soybean varieties with high EC content via marker-assisted selection.
Pyruvate kinase 2 from Synechocystis sp. PCC 6803 increased substrate affinity via glucose-6-phosphate and ribose-5-phosphate for phosphoenolpyruvate consumption
Authors: Karikomi Masahiro , Katayama Noriaki , Osanai Takashi 
Published: May 2024

AbstractPyruvate kinase (Pyk, EC 2.7.1.40) is a glycolytic enzyme that generates pyruvate and adenosine triphosphate (ATP) from phosphoenolpyruvate (PEP) and adenosine diphosphate (ADP), respectively. Pyk couples pyruvate and tricarboxylic acid metabolisms. Synechocystis sp. PCC 6803 possesses two pyk genes (encoded pyk1, sll0587 and pyk2, sll1275). A previous study suggested that pyk2 and not pyk1 is essential for cell viability; however, its biochemical analysis is yet to be performed. Herein, we biochemically analyzed Synechocystis Pyk2 (hereafter, SyPyk2). The optimum pH and temperature of SyPyk2 were 7.0 and 55 °C, respectively, and the Km values for PEP and ADP under optimal conditions were 1.5 and 0.053 mM, respectively. SyPyk2 is activated in the presence of glucose-6-phosphate (G6P) and ribose-5-phosphate (R5P); however, it remains unaltered in the presence of adenosine monophosphate (AMP) or fructose-1,6-bisphosphate. These results indicate that SyPyk2 is classified as PykA type rather than PykF, stimulated by sugar monophosphates, such as G6P and R5P, but not by AMP. SyPyk2, considering substrate affinity and effectors, can play pivotal roles in sugar catabolism under nonphotosynthetic conditions.
Revolutions and corruption
Authors: Ammons Joshua D. , Shakya Shishir 
Published: May 2024

AbstractWe investigate the relationship between successful revolutions and corruption using data on revolutionary campaigns since 1900 and corruption measures retrieved from the Varieties of Democracy database. We find that successful nonviolent and violent revolutions produce null effects on corruption; education decreases corruption; and upon adjusting for the moderating effect of education, violent revolutions induce corruption. Our results imply that classic narratives celebrating such upheavals as corruption-limiting are oversimplified and optimistic. Our analysis challenges conventional wisdom and contributes an instructive, empirically-grounded assessment of the revolution’s corruption consequences to the scholarship.
‘In the company of cheerful ladies’: whether female entrepreneurs are more productive?
Authors: Mickiewicz Tomasz , Nguyen Bach 
Published: May 2024

AbstractAfter over two decades, the debate on the female underperformance hypothesis remains not concluded. This study sheds some new light on the hypothesis by (i) showing that surrounding institutional forces play an important role in determining how female businesses perform and (ii) arguing that to understand gender differences (or lack of those) in performance, we need to look at productivity alongside profitability, revenues, and growth. Specifically, we posit that, in certain developing countries, female entrepreneurs devise specific strategies to cope with challenging institutional contexts. In such contexts, female entrepreneurs have less opportunity to realize economic rents compared to males, but they respond to these constraints by becoming more efficient in resource use through relying on female employment. Investigating a large set of longitudinal data from Vietnam, we find that female businesses are more productive than male businesses, and that this effect is stronger when female owner-managers employ more female employees, or even female employees only. However, we also find that these positive effects are weakened with increased corruption. This provides important implications for female entrepreneurs and policymakers in developing countries.
The nature and difficulty of physical efforts
Authors: Massin Olivier 
Published: May 2024

AbstractWe make physical efforts when we swim, carry shopping bags, push heavy doors, or cycle up hills. A growing concern among philosophers and scientists in related fields is the absence of a well-defined concept for physical efforts. This paper addresses this issue by presenting a force-based definition of physical efforts. In Sect. 1, we explore the shortcomings of existing definitions of effort. Section 2 introduces the force-based account of efforts according to which making an effort consists in exerting a force so as to make an object move or stay at rest. Section 3 introduces three central distinctions stemming from the account: failed vs. successful efforts; resisted vs. unresisted efforts; and efforts vs. effortful actions. Section 4 presents a key objection, to the effect that the force-based theory cannot account for the difficulty of efforts: efforts usually feel difficult, but effort’s difficulty is not always a function of the magnitude of force(s) exerted. Section 5 argues that the most in-depth account of difficulty so far, that developed by Bradford (2015), cannot account for the difficulty of efforts. Sections 6 & 7 develop a novel account of effort’s difficulty.
Competitive wages and tax evasion in a Cournot duopoly
Authors: Buccella Domenico , Fanti Luciano , Gori Luca 
Published: May 2024

AbstractIn a Cournot duopoly with indirect tax evasion, this paper counter-intuitively shows that, in the presence of positive competitive wages, a higher indirect taxation may increase expected profits. This result is likely to occur if the market size (or alternatively, if the cost pressure exerted by wages) is adequately large and the detection probability is not too high, and it is equivalent irrespective of firms optimally choosing either the tax base to disclose to the tax authority or the amount of evasion tout-court.
Evolution and global research trends of immunity in diabetic nephropathy: a bibliometric and visual analysis from 2004 to 2023
Authors: Zhou Jianlong , Zhu Lv , Yue Rensong 
Published: May 2024

Abstract
Background
Diabetic nephropathy (DN) is the leading cause of end-stage renal disease, with an increasing prevalence worldwide, but its pathomechanisms remain incompletely understood. Accumulating evidence suggests that immunity plays an important role in the development of DN. Many papers have been published in the field over the last 20 years, but there has been no bibliometric review of the research hotspots and trends in the field. This study aimed to assess the current research status and future trends of the link between immune and DN using bibliometric analysis.

Methods
Publications on the association between immunity and DN from 2004 to 2023 were retrieved from the Web of Science Core Collection database and screened according to inclusion criteria. VOSviewer and CiteSpace software were employed to visualize research trends and hotspots in the field. Data including author, institution, country, journal, reference, and keyword were analyzed.

Results
Ultimately 1246 publications meeting the criteria were included in the bibliometric analysis, involving 838 articles (84.96%) and 408 reviews (15.04%). The literature covered 81 countries and regions, 1751 institutions, and 6584 authors. The top 2 countries in terms of the number of publications were China (435) and the United States (318), and they collaborated most frequently. The United States had the highest number of citations for published papers (18,161), far exceeding the other countries. England had 38 publications but had the highest average number of citations (92.32). The University of California system was the most prolific institution (25 papers, 1062 citations, 42.48 citations per paper). Frontiers in Immunology was the most prolific journal in the field (30 papers). The most cited journal was Kidney International (863 citations). The analysis of keywords and references showed that inflammation, ferroptosis, and lipid metabolism may be future research hotspots in this field.

Conclusions
The number of publications related to immunity and DN has increased annually over the past 20 years, with a significant increase in the last 3 years especially. Our results identified research hotspots and trends in the field. These findings provide valuable perspectives for future research, enhancing our understanding of the immune-related mechanisms of DN and exploring potential therapeutic strategies.
Upregulation of Immune checkpoint PD-L1 in Colon cancer cell lines and activation of T cells by Leuconostoc mesenteroides
Authors: Altves Safaa , Guclu Ebru , Yetisgin Esra , Bilecen Kivanc , Vural Hasibe 
Published: May 2024

Abstract
Globally colorectal cancer ranks as the third most widespread disease and the third leading cause of cancer-associated mortality. Immunotherapy treatments like PD-L1 blockade have been used to inhibit the PD-L1 legend, which boosts the activity of cytotoxic T lymphocytes. Recently, studies suggest that some probiotics could potentially enhance the effectiveness of immunotherapy treatments for cancer patients. We found that in Caco-2 and HT-29 cells, the live Leuconostoc mesenteroides treatment resulted an increase in the PD-L1 expression and this treatment stimulated interferon-gamma (IFN-γ) production in Jurkat T-cells. Due to the well-established ability of IFN-γ to enhance PD-L1 expression, the combination of IFN-γ and L. mesenteroides was used in colon cancer cell lines and a resulting remarkable increase of over tenfold in PD-L1 expression was obtained. Interestingly, when L. mesenteroides and IFN-γ are present, the blockage of PD-L1 using PD-L1 antibodies not only improved the viability of Jurkat T-cells but also significantly boosted the levels of IFN-γ and IL-2, the T-cells activation marker cytokines. In addition to upregulating PD-L1, L. mesenteroides also activated Toll-like receptors (TLRs) and NOD-like receptors (NODs) pathways, specifically through TLR2 and NOD2, while also exerting a suppressive effect on autophagy in colon cancer cell lines. In conclusion, our findings demonstrate a significant upregulation of PD-L1 expression in colon cancer cells upon co-culturing with L. mesenteroides. Moreover, the presence of PD-L1 antibodies during co-culturing activates Jurkat T cells. The observed enhancement in PD-L1 expression may be attributed to the inhibition of the Autophagy pathway or activation of the hippo pathway.

Graphical abstract text
The administration of Live Lactobacillus mesenteroides on colon cancer cells leads to the elevation of PD-L1, with a further increase observed in the presence of IFN-γ. Co-cultivation of Live L. mesenteroides with colon cancer cells in conjunction with anti-PD-L1 blockade antibody results in the enhanced viability of T cells.

Key Points

Co-culturing L. mesenteroides increases PD-L1 gene and protein transaction in colon cancer.

L. mesenteroides existing enhances T cells viability and activity.

GPCR41/42 is a possible link between L. mesenteroides, YAP-1 and PD-L1.
CD73 polymorphisms are associated with schizophrenia
Authors: Peng He-Xia , Zhang Li-Li , Jiang Dan , Jian Na , Zhang Ting-Mei , Luo Jia-Guo , Yin Hai-Yan 
Published: May 2024

AbstractEcto-5’-nucleotidase/CD73 enzyme plays a key role in the regulation of extracellular adenosine levels, thereby exerting influence on adenosine homeostasis. Emerging evidence suggests that perturbations in purines and ecto-5’-nucleotidase activity are associated with an augmented susceptibility to schizophrenia. However, the precise impact of genetic variations in CD73 on individuals with schizophrenia remains poorly understood. Here, our study demonstrated that rs3734442 allele and rs4431401 heterozygote were conferred a significant risk of schizophrenia disease (rs3734442: odds ratio, 0.556; 95% CI, 0.375 to 0.825; p = 0.004; rs4431401: odds ratio, 1.881, 95% CI, 1.117 to 3.166; p = 0.020). Comparing different genders, we observed a significant association between rs3734442 genotypes and male cases (rs3734442: odds ratio, 0.452; 95% CI, 0.257 to 0.796; p = 0.007). Likewise, there was a significant association between rs4431401 genotypes and male patients (rs4431401: odds ratio, 2.570; 95% CI, 1.196 to 5.522; p = 0.015). Based on family history and antipsychotics medication usage, our data reveals that the rs9444348 allele exhibits the most significant association with familial susceptibility to schizophrenia (odds ratio, 1.541; 95% CI, 1.009 to 2.353; p = 0.048 for A vs G). Moreover, individuals carrying variants of rs6922, rs2229523, and rs2065114 while being treated with clozapine demonstrate a higher frequency proportion compared to those receiving risperidone treatment (p = 0.035; p = 0.049; p = 0.027 respectively). Additionally, our results indicate that patients with GG genotype of rs9444348 had significantly higher likelihood of using clozapine instead of sulpiride (p = 0.048). Overall, our data strongly suggest that genetic variations in CD73 are significantly associated with schizophrenia risk and may serve as valuable resources for identifying therapeutic targets.
Various tomato infection discrimination using spectroscopy
Authors: Ruszczak Bogdan , Smykała Krzysztof , Tomaszewski Michał , Navarro Lorente Pedro Javier 
Published: May 2024

AbstractDiagnosing plant diseases is a difficult task, but it could be made easier with the use of advanced instrumentation and the latest machine learning techniques. This paper is a further development of a previous authors study by the authors, which has been extended to provide the classification method for tomato diseases and to indicate the spectral ranges of greatest importance for this process. As tomatoes are one of the most popular and consumed vegetables, and diseases of this crop even reduce yields by up to 80% every year, their detection is a vague topic. This manuscript describes research in which spectroscopy was used to develop methods for discriminating between selected tomato diseases. The following, frequently occurring diseases were investigated for this research: anthracnose, bacterial speck, early blight, late blight, and Septoria Leaf Spot. The study used a dataset consisting of 3877 measurements taken with the ASD FieldSpec 4 Hi-Res spectroradiometer in the 350–2500 nm range from 2019/09/10 to 2019/12/20. The highest classification efficiency ($$F_1$$

F
1

score) of 0.896 was obtained for the logistic regression based model which was evaluated on Septoria Leaf Spot disease records.
Degrowth or secular stagnation? The political economy of monopoly finance capital and the stagnation-accumulation treadmill
Authors: Clark Tim P. 
Published: May 2024

AbstractCapitalism is often described as a “growth machine,” whose insatiable growth imperative(s) must either be halted to protect ecologies or repurposed by some kind of socialist or social democratic state. However, the continuation of robust growth rates in many countries seems unlikely under present conditions. As monopoly capital scholars have long theorized, late-stage capitalist economies are characterized by a “cancerous malaise” of secular stagnation. In accordance with this perspective, financialization emerged to overcome challenges associated with this cancerous malaise. Using the U.S. economy as a case study, low growth and accelerating accumulation are interlinked under the socio-historic conditions of monopoly finance capital. This interrelation is captured by the term “stagnation-accumulation treadmill,” which stresses that the expansion of finance ensures the systemic requirement to increase material throughputs despite rising obstacles to robust growth. I argue that this interrelationship can help explain the paradox of increased consumption in the Global North alongside increased economic immiseration of the non-propertied working class. This argument stresses the continued materiality of a growth-dependent capitalist economy, even—if not especially—one characterized by stagnation and the explosion of so-called “non-real” finance sectors.