bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health Information–Seeking Behaviors, Health Indicators, and Health Risks
Authors: Weaver James B. , Mays Darren , Weaver Stephanie Sargent , Hopkins Gary L. , Eroğlu Doğan , Bernhardt Jay M. 
Published: June 2010

Objectives. We examined how different types of health information–seeking behaviors (HISBs)—no use, illness information only, wellness information only, and illness and wellness information combined—are associated with health risk factors and health indicators to determine possible motives for health information seeking. Methods. A sample of 559 Seattle–Tacoma area adults completed an Internet-based survey in summer 2006. The survey assessed types of HISB, physical and mental health indicators, health risks, and several covariates. Covariate-adjusted linear and logistic regression models were computed. Results. Almost half (49.4%) of the sample reported HISBs. Most HISBs (40.6%) involved seeking a combination of illness and wellness information, but both illness-only (28.6%) and wellness-only (30.8%) HISBs were also widespread. Wellness-only information seekers reported the most positive health assessments and the lowest occurrence of health risk factors. An opposite pattern emerged for illness-only information seekers. Conclusions. Our findings reveal a unique pattern of linkages between the type of health information sought (wellness, illness, and so on) and health self-assessment among adult Internet users in western Washington State. These associations suggest that distinct health motives may underlie HISB, a phenomenon frequently overlooked in previous research.
Hybrid cells differentiate to hepatic lineage cells and repair oxidative damage
Authors: Xu Dan , Wang Feng , Gu Hongyan , Wang Jia , Guo Qinglong , Zhang Yanli , Wang Ziyu 
Published: June 2010

AbstractHybrid cells derived from stem cells play an important role in organogenesis, tissue regeneration and cancer formation. However, the fate of hybrid cells and their range of function are poorly understood. Fusing stem cells and somatic cells induces somatic cell reprogramming, and the resulting hybrid cells are embryonic stem cell-like cells. Therefore, we hypothesize that fusion-induced hybrid cells may behave like ES cells in certain microenvironments. In this study, human hepatic cells were induced to apoptosis with H2O2, and then co-cultured with hybrid cells that had been derived from mouse ES cells and human hepatic cells using a transwell. After co-culturing, the degree of apoptosis was evaluated using Annexin-V/PI double-staining analysis, flow cytometry and Western-blot. We observed that H2O2-induced cell apoptosis was inhibited by co-culture. In addition, the activity of injury-related enzymes (GSH-Px, LDH and SOD) and the level of albumin release in the co-culture system trended toward the level of normal undamaged hepatic cells. The stably increased levels of secretion of ALB in the co-culture system also confirmed that co-culture with hybrid cells helped in recovery from injury. The fate of the hybrid cells was studied by analyzing their gene expression and protein expression profiles. The results of RT-PCR indicated that during co-culturing, like ES cells, hybrid cells differentiated into hepatic lineage cells. Hybrid cells transcripted genes from both parental cell genomes. Via immunocytochemical analysis, hepatic directional differentiation of the hybrid cells was also confirmed. After injecting the hybrid cells into the mouse liver, the GFP-labeled transplanted cells were distributed in the hepatic lobules and engrafted into the liver structure. This research expands the knowledge of fusion-related events and the possible function of hybrid cells. Moreover, it could indicate a new route of differentiation from pluripotent cells to tissue-specific cells via conditional co-culture.
Real-Time Kinematic, Temporospatial, and Kinetic Biofeedback During Gait Retraining in Patients: A Systematic Review
Authors: Tate Jeremiah J. , Milner Clare E. 
Published: June 2010

BackgroundBiofeedback has been used in rehabilitation settings for gait retraining.PurposeThe purpose of this review was to summarize and synthesize the findings of studies involving real-time kinematic, temporospatial, and kinetic biofeedback. The goal was to provide a general overview of the effectiveness of these forms of biofeedback in treating gait abnormalities.Data SourcesArticles were identified through searches of the following databases: MEDLINE, CINAHL (Cumulative Index to Nursing and Allied Health Literature), and Cochrane Central Register for Controlled Trials. All searches were limited to the English language and encompassed the period from 1965 to November 2007.Study SelectionTitles and abstracts were screened to identify studies that met the following requirements: the study included the use of kinematic, temporospatial, or kinetic biofeedback during gait training, and the population of interest showed abnormal movement patterns as a result of a pathology or injury.Data ExtractionAll articles that met the inclusion criteria were assessed by use of the Methodological Index for Nonrandomized Studies.Data SynthesisSeven articles met the inclusion criteria and were included in the review. Effect sizes were calculated for the primary outcome variables for all studies that provided enough data. Effect sizes generally suggested moderate to large treatment effects for all methods of biofeedback during practice.LimitationsSeveral of the studies lacked adequate randomization; therefore, readers should exercise caution when interpreting authors’ conclusions.ConclusionsEach biofeedback method appeared to result in moderate to large treatment effects immediately after treatment. However, it is unknown whether the effects were maintained. Future studies should ensure adequate randomization of participants and implementation of motor learning concepts and should include retention testing to assess the long-term success of biofeedback and outcome measures capable of demonstrating coordinative changes in gait and improvement in function.
The Cancer Rehabilitation Journey: Barriers to and Facilitators of Exercise Among Patients With Cancer-Related Fatigue
Authors: Blaney Janine , Lowe-Strong Andrea , Rankin Jane , Campbell Anna , Allen James , Gracey Jackie 
Published: June 2010

Background
Despite the evidence to support exercise as an effective management strategy for patients with cancer-related fatigue (CRF), many of the general cancer population are sedentary.

Objective
The aim of this study was to explore the barriers to and facilitators of exercise among a mixed sample of patients with CRF.

Design
An exploratory, descriptive, qualitative design was used.

Methods
Purposive sampling methods were used to recruit patients with CRF who were representative of the cancer trajectory, that is, survivors of cancer and patients in palliative care who were recently diagnosed and undergoing treatment. Focus group discussions were transcribed verbatim and analyzed using a grounded theory approach. Lower-level concepts were identified and ordered into subcategories. Related subcategories then were grouped to form the main categories, which were linked to the core category.

Results
Five focus groups were conducted with 26 participants. Within the core category of the cancer rehabilitation journey were 3 main categories: (1) exercise barriers, (2) exercise facilitators, and (3) motivators of exercise. Exercise barriers were mainly related to treatment side effects, particularly fatigue. Fatigue was associated with additional barriers such as physical deconditioning, social isolation, and the difficulty of making exercise a routine. Environmental factors and the timing of exercise initiation also were barriers. Exercise facilitators included an exercise program being group-based, supervised, individually tailored, and gradually progressed. Exercise motivators were related to perceived exercise benefits.

Conclusions
Individuals with CRF have numerous barriers to exercise, both during and following treatment. The exercise facilitators identified in this study provide solutions to these barriers and may assist with the uptake and maintenance of exercise programs. These findings will aid physical therapists in designing appropriate exercise programs for patients with CRF.
Prospective Clinical Pilot Trial in a Single Cohort Group of rhPDGF in Foot Arthrodeses
Authors: Daniels Timothy , DiGiovanni Christopher , Lau Johnny T. C. , Wing Kevin , Younger Alastair 
Published: June 2010

Background: Augment™ Bone Graft, a fully synthetic bone graft material composed of recombinant human PDGF and a calcium phosphate matrix (rhPDGF/TCP), has been considered as a possible alternative to autogenous bone graft. Before proceeding with randomized control studies comparing rhPDGF/TCP to autograft bone, a human trial to assess efficacy and safety was required. Materials and Methods: The current study was a prospective, open-label, multi-center trial designed to evaluate rhPDGF in a calcium phosphate matrix (Augment™ Bone Graft). Sixty patients requiring hindfoot or midfoot fusion were prospectively followed for 36 weeks. All patients received 0.9 to 2.7 mg of rhPDGF at the fusion sites and returned for clinical and radiographic review at Day 7 to 14 and Weeks 6, 9, 12, 16, 24, and 36. Computerized tomography (CT) scans of the fusion site were obtained at the 6- and 12-week postoperative appointment, with an additional CT scan at 16 weeks if required. Results: No patients suffered a serious adverse event caused by rhPDGF. CT scan evaluation at 12- to 16-week time periods revealed moderate or complete osseous bridging of 75% (44/59) at 36 weeks. Conclusion: These results indicate that rhPDGF is a safe product and provides clinical/radiographic outcomes that justify the pursuit of randomized controlled studies comparing rhPDGF/TCP to autograft. Level of Evidence: IV, Case Series
Ankle Arthrodesis Using Anatomically Contoured Anterior Plate
Authors: Guo Changan , Yan Zuoqin , Barfield William R. , Hartsock Langdon A. 
Published: June 2010

Background: More than 40 fusion techniques for the ankle joint have been reported. The purpose of this retrospective study was to review our preliminary clinical and radiographic results using an anatomically contoured anterior plate for ankle arthrodesis. Materials and Methods: Ten ankle arthrodeses with an anatomically contoured anterior plate performed by a single surgeon were reviewed with an average of 14 months followup. One underwent revision surgery due to screw loosening by reapplying the same plate. Plain radiographs were taken to help determine the stability of fixation and time of fusion. The AOFAS clinical rating system was applied to evaluate patients preoperatively and postoperatively. Results: Nine of ten patients achieved solid fusion radiographically and clinically at an average of 15 (range, 12 to 22) weeks. Bony healing was achieved after an additional 12 weeks for the patient who underwent revision fusion. There were no postoperative wound problems or infections. All patients reported an improvement in their pain level following successful fusion. Conclusion: The application of an anatomically contoured plate provides many advantages, including less soft tissue disruption by using a single anterior incision, ease of deformity correction, early rehabilitation, and high rate of union. Level of Evidence: IV, Retrospective Case Series
Plyometric Training Versus Resistive Exercises After Acute Lateral Ankle Sprain
Authors: Ismail Manal M. , Ibrahim Mohamed M. , Youssef Enas F. , Shorbagy Khaled M. El 
Published: June 2010

Background: Plyometric training is a widely used method to improve performance in healthy athletes. It is highly recommended in the late stage of rehabilitation of many lower limb injuries. However, its effects on muscle strength and function in management of lateral ankle sprain have not been reported. Therefore, the objective of the current study was to determine the effects of plyometric training versus resistive exercises on muscle strength and function following acute lateral ankle sprain. Materials and Methods: Twenty-two athletes (aged from 20 to 35 years) of both sexes with grade I or II unilateral inversion ankle sprain participated in the study (at least 3 weeks after acute injury). They were randomly assigned to two groups. The first group received plyometric training, whereas the second one received resistive training for 6 weeks. Isokinetic peak torque/body weight for invertors and evertors at 30 degrees/s and 120 degrees/s and functional tests were assessed before and after training. Results: Both plyometric and resistive training improve isokinetic evertor and invertor peak torques and functional performance of athletes p < 0.05. There were no significant differences between groups concerning peak torque/body weight for invertors and evertors at both speeds measured p > 0.05. The functional test measures of the plyometric group were significantly higher than that of resistive group. Conclusion: Plyometrics were more effective than resistive exercises in improving functional performance of athletes after lateral ankle sprain. Level of Evidence: I, Prospective Randomized Study
Study of the Inhibitive Action of Bakery Waste for Corrosion of Mild Steel in Acid Medium
Authors: Rajalakshmi R. , Subhashini S. , Leelavathi S. , Geethanjali R. 
Published: June 2010

Bakery waste-egg shell extract was tested for its inhibitory effect towards mild steel in0.5 M H2SO4 solution. The corrosion behavior of the egg shell extract on mild steel (MS)was investigated using weight loss experiments, polarization and impedance measurements.It was found that the egg shell extract has good inhibitive action, showing 97.8% efficiency.Inhibition efficiency increased with increasing concentrations of the egg shell extract.Temperature studies were conducted to evaluate the kinetic and thermodynamic parameters.The corrosion inhibition takes place via monolayer type of adsorption on MS surface.Experimental results are fitted into various adsorption isotherms. Tafel polarization studiesrevealed the mixed mode of inhibition of the egg shell extract. Electrochemical impedanceresults also confirmed the inhibitive nature of the egg shell extract. The results obtainedshowed that the extract of the egg shell could serve as an effective, zero cost,environmentally friendly inhibitor for the corrosion of mild steel in sulphuric acid medium.Keywords: Egg shell, corrosion, inhibition, mild steel, H2SO4 solutionDOI: 10.3126/jncs.v25i0.3282Journal of Nepal Chemical Society Volume 25, 2010 pp 29-36
Low Temperature Soft Chemical Synthesis of Bright Blue CoAl<sub>2</sub>O<sub>4</sub> Spinel Particles
Authors: Stella K. Christine , Nesara A. Samson 
Published: June 2010

Present work reports the preparation of bright blue CoAl2O4 spinel particles by lowtemperature soft chemical route using urea or glycine as fuel in this paper. Thecharacterization of the resulting powder was done using x-ray diffraction (XRD), particlesize analysis and scanning electron microscopic (SEM) techniques. Pure CoAl2O4 spinelparticles were prepared at relatively low temperature using this soft chemistry route at avery short duration (< 10 minutes) which is also very simple than other techniques such assolid state reaction, ceramic methods and so on. From the particle size analysis, it wasfound that the spinel particles with low diameter (below 35 μm) were formed. The SEMphotographs showed the formation of fluffy morphology with porous structure.Keywords: Cobalt aluminate spinel, low temperature soft chemistry route, XRD, SEM.DOI: 10.3126/jncs.v25i0.3302Journal of Nepal Chemical Society Volume 25, 2010 pp 62-69
Dry Media Synthesis of Novel Pyrrolo-pyrimidines
Authors: Mishra A. D. 
Published: June 2010

A series of new 2-thioxo-3,7-disubstituted-5,6-diphenylpyrrolo[2,3-d]pyrimidin-4(1H)-ones have been synthesized by the condensation of 2-amino3-ethylcarboxylate-4,5-diphenylpyrroles with mono-substituted arylthioureas in dry media under microwave irradiations.All the synthesized compounds were screened for their antifungal and antibacterialactivities and found to possess mild to moderate antimicrobial activities.Keywords: Thioureas, Pyrrolo-pyrimidines, Microwave irradiation, Antimicrobial activities.DOI: 10.3126/jncs.v25i0.3306Journal of Nepal Chemical Society Volume 25, 2010 pp 83-88
Effect of cold nerve allograft preservation on antigen presentation and rejection
Authors: Ray Wilson Z. , Kale Santosh S. , Kasukurthi Rahul , Papp Esther M. , Johnson Philip J. , Santosa Katherine B. , Yan Ying , Hunter Daniel A. , Mackinnon Susan E. , Tung Thomas H. 
Published: June 2010

Object
Nerve allotransplantation provides a temporary scaffold for host nerve regeneration and allows for the reconstruction of significant segmental nerve injuries. The need for systemic immunosuppression, however, limits the current clinical utilization of nerve allografts, although this need is reduced by the practice of cold nerve allograft preservation. Activation of T cells in response to alloantigen presentation occurs in the context of donor antigen presenting cells (direct pathway) or host antigen-presenting cells (indirect pathway). The relative role of each pathway in eliciting an alloimmune response and its potential for rejection of the nerve allograft model has not previously been investigated. The objective of this investigation was to study the effect of progressive periods of cold nerve allograft preservation on antigen presentation and the alloimmune response.

Methods
The authors used wild type C57Bl/6 (B6), BALB/c, and major histocompatibility Class II–deficient (MHC−/−) C57Bl/6 mice as both nerve allograft recipients and donors. A nonvascularized nerve allograft was used to reconstruct a 1-cm sciatic nerve gap. Progressive cold preservation of donor nerve allografts was used. Quantitative assessment was made after 3 weeks using nerve histomorphometry.

Results
The donor-recipient combination lacking a functional direct pathway (BALB/c host with MHC−/− graft) rejected nerve allografts as vigorously as wild-type animals. Without an intact indirect pathway (MHC−/− host with BALB/c graft), axonal regeneration was improved (p < 0.052). One week of cold allograft preservation did not improve regeneration to any significant degree in any of the donor-recipient combinations. Four weeks of cold preservation did improve regeneration significantly (p < 0.05) for all combinations compared with wild-type animals without pretreatment. However, only in the presence of an intact indirect pathway (no direct pathway) did 4 weeks of cold preservation improve regeneration significantly compared with 1 week and no preservation in the same donorrecipient combination.

Conclusions
The indirect pathway may be the predominant route of antigen presentation in the unmodified host response to the nerve allograft. Prolonged duration of cold nerve allograft preservation is required to significantly attenuate the rejection response. Cold preservation for 4 weeks improves nerve regeneration with a significant effect on indirect allorecognition.
Intratumoral hemorrhage and fibrosis in vestibular schwannoma: a possible mechanism for hearing loss
Authors: Sughrue Michael E. , Kaur Rajwant , Kane Ari J. , Rutkowski Martin J. , Yang Isaac , Pitts Lawrence H. , Tihan Tarik , Parsa Andrew T. 
Published: June 2010

Object
Vestibular schwannomas (VSs) are benign lesions with an unpredictable natural history. Perhaps the greatest barrier to predicting which patients need treatment is our poor understanding of how these tumors cause hearing loss in the first place. In this case-control study, the authors investigated the relationship between preoperative hearing loss and histological changes such as intratumoral microhemorrhage and extensive fibrosis.

Methods
From a prospectively collected database, the authors selected all patients with VS who had undergone microsurgical resection as their initial treatment for histopathologically confirmed VS. Histological specimens obtained in 274 of these patients were systematically reviewed by a blinded neuropathologist who graded the extent of microhemorrhage and fibrosis in these tumors. The effect of these variables on preoperative hearing loss was studied using binary logistic regression.

Results
On univariate analysis, patients with extensive intratumoral microhemorrhage or fibrosis (p < 0.0001), patients with larger tumors (p < 0.05), and patients 65 years of age or older (p < 0.05) were significantly more likely to have unserviceable hearing at the time of surgery. On multivariate analysis, only patients with extensive intratumoral microhemorrhage or fibrosis had an increased risk of having unserviceable hearing at the time of surgery (OR 3.72, 95% CI 1.3–10; p = 0.01). Older age and tumor size greater than 3 cm were not statistically significant risk factors for hearing loss, controlling for the effect of microhemorrhage and fibrosis.

Conclusions
In this study, the authors have demonstrated a correlation between the extent of nonneoplastic histological changes, such as microhemorrhage and fibrosis, and hearing loss. This alternate hypothesis has the potential to explain many of the exceptions to previously described mechanisms of hearing loss in patients with VS. The advent of high-resolution MR imaging technology to identify microhemorrhages may provide a method to screen for patients with VS at risk for hearing loss.
Hemoglobin and Plasma Vitamin C Levels in Patients on Peritoneal Dialysis
Authors: Finkelstein Fredric O. , Juergensen Peter , Wang Suxin , Santacroce Sally , Levine Mark , Kotanko Peter , Levin Nathan W. , Handelman Garry J. 
Published: June 2010

Objective To determine the contribution of vitamin C (Vit C) status in relation to hemoglobin (Hb) levels in patients on long-term peritoneal dialysis (PD). Methods 56 stable PD patients were evaluated in a cross-sectional survey. Plasma samples were collected for Vit C (analyzed by HPLC with electrochemical detection) and high-sensitivity C-reactive protein (hs-CRP) determinations. Clinical records were reviewed for Hb, transferrin saturation (TSAT), ferritin, erythropoietin (EPO) dose, and other clinical parameters. Dietary Vit C intake was evaluated by patient survey and from patient records. Total Vit C removed during PD treatment was measured in 24-hour dialysate collections. Results Patients showed a highly skewed distribution of plasma Vit C levels, with 40% of patients below normal plasma Vit C levels (<30 μmol/L) and 9% at higher than normal levels (>80 μmol/L). Higher plasma Vit C levels were associated with higher Hb levels (Pearson r = 0.33, p < 0.004). No direct connection between Vit C levels and reported dietary intake could be established. In stepwise multiple regression, plasma Vit C remained significantly associated with Hb ( p = 0.017) but there was no significant association with other variables (dialysis vintage, age, ferritin, TSAT, hs-CRP, residual renal function, and EPO dose). In 9 patients that were evaluated for Vit C in dialysate, plasma Vit C was positively associated (Spearman r = 0.85, p = 0.01) with the amount of Vit C removed during dialysis treatment. Conclusions These data indicate that plasma Vit C is positively associated with higher Hb level. Vit C status could play a major role in helping PD patients to utilize iron for erythropoiesis and achieve a better Hb response during anemia management.