bluuebunny/crossref_metadata_2025_split huggingface dataset:
A “Transformers”‐like nanochain for precise navigation and efficient cancer treatment
Authors: Tian Sichao , Zeng Qian , Hu Zhanglu , Zhang Weidong , Ao Zhuo , Han Dong , Xu Qing‐Hua 
Published: April 2024

AbstractIntegrated multimodal imaging in theranostics nanomaterials offers extensive prospects for precise and noninvasive cancer treatment. Precisely controlling the structural evolution of plasmonic nanoparticles is crucial in the development of photothermal agents. However, previous successes have been limited to static assemblies and single‐component structures. Here, an activatable plasmonic theranostics system utilizing self‐assembled 1D silver‐coated gold nanochains (1D nanochains) is presented for precise tumor diagnosis and effective treatment. The absorbance of the adaptable core–shell chain structure can shift from visible to near‐infrared (NIR) regions due to the fusion between nearby Au@Ag nanoparticles induced by elevated H2O2 levels in the tumor microenvironment (TME), resulting in the creation of a novel 3D aggregates with strong NIR absorption. With a high photothermal conversion efficiency of 60.2% at 808 nm, nanochains utilizing the TME‐activated characteristics show remarkable qualities for photoacoustic imaging and significantly limit tumor growth in vivo. This study may pave the way for precise tumor diagnosis and treatment through customizable, optically tunable adaptive plasmonic nanostructures.
A Versatile Microfluidic Platform for Extravasation Studies Based on DNA Origami—Cell Interactions
Authors: García‐Chamé Miguel , Wadhwani Parvesh , Pfeifer Juliana , Schepers Ute , Niemeyer Christof M. , Domínguez Carmen M. 
Published: April 2024

AbstractThe adhesion of circulating tumor cells (CTCs) to the endothelial lumen and their extravasation to surrounding tissues are crucial in the seeding of metastases and remain the most complex events of the metastatic cascade to study. Integrins expressed on CTCs are major regulators of the extravasation process. This knowledge is primarily derived from animal models and biomimetic systems based on artificial endothelial layers, but these methods have ethical or technical limitations. We present a versatile microfluidic device to study cancer cell extravasation that mimics the endothelial barrier by using a porous membrane functionalized with DNA origami nanostructures (DONs) that display nanoscale patterns of adhesion peptides to circulating cancer cells. The device simulates physiological flow conditions and allows direct visualization of cell transmigration through microchannel pores using 3D confocal imaging. Using this system, we studied integrin‐specific adhesion in the absence of other adhesive events. Specifically, we show that the transmigration ability of the metastatic cancer cell line MDA‐MB‐231 is influenced by the type, distance, and density of adhesion peptides present on the DONs. Furthermore, studies with mixed ligand systems indicate that integrins binding to RGD (arginine‐glycine‐aspartic acid) and IDS (isoleucine‐aspartic acid‐serine) did not synergistically enhance the extravasation process of MDA‐MB‐231 cells.
Autophagy‐Inducing MoO3‐x Nanowires Boost Photothermal‐Triggered Cancer Immunotherapy
Authors: He Lizhen , Chen Qi , Lu Qichen , Yang Meijin , Xie Bin , Chen Tianfeng , Wang Xun 
Published: April 2024

AbstractAutophagy could play suppressing role in cancer therapy by facilitating release of tumor antigens from dying cells and inducing immunogenic cell death (ICD). Therefore, discovery and rational design of more effective inducers of cytotoxic autophagy is expected to develop new strategies for finding innovative drugs for precise and successful cancer treatment. Herein, we develop MoO3‐x nanowires (MoO3‐x NWs) with high oxygen vacancy and strong photothermal responsivity to ablate tumors through hyperthermia, thus promote the induction of cytotoxic autophagy and severe ICD. As expected, the combination of MoO3‐x NWs and photothermal therapy (PTT) effectively induces autophagy to promote the release of tumor antigens from the ablated cells, and induces the maturation and antigen presentation of dendritic cells (DCs), subsequently activates cytotoxic T lymphocytes (CTLs)‐mediated adaptive immunity. Furthermore, the combination treatment of MoO3‐x NWs with immune checkpoint blockade of PD‐1 could promote the tumor‐associated macrophages (TAMs) polarization into tumor‐killing M1 macrophages, inhibit infiltration of Treg cells at tumor sites, and alleviate immunosuppression in the tumor microenvironment, finally intensify the anti‐tumor activity in vivo. This study provides a strategy and preliminary elucidation of the mechanism of using MoO3‐x nanowires with high oxygen vacancy to induce autophagy and thus enhance photothermal immunotherapy.
Ligand Meta‐Anchoring Strategy in Metal–Organic Frameworks for Remarkable Promotion of Quantum Yields
Authors: Yu Qicheng , Sung Herman H. Y. , Gao Feng , Williams Ian D. , Lam Jacky W. Y. , Sun Jianwei , Tang Ben Zhong 
Published: April 2024

AbstractAggregation is a conventional method to enhance the quantum yields (QYs) of pure organic luminophores due to the restriction of intramolecular motions (RIM). However, how to realize RIM in metal–organic frameworks (MOFs) is still unclear and challenging. In this work, the ligand meta‐anchoring strategy is first proposed and proved to be an effective and systematic approach to restrict the intramolecular motions of MOFs for the QY improvement. By simply shifting the substituent position in the ligand from para to meta, the QY of the resulting MOF is significantly enhanced by eleven‐fold. The value is even higher than that of ligand aggregates, demonstrating the strong RIM effect of this ligand meta‐anchoring strategy. The introduction of co‐ligand induces the appearance of visible yellow room temperature phosphorescence with a lifetime of 222 ms due to the QY enhancement and the charge transfer between the donor and accepter units. The present work thus broadens the understanding of the RIM mechanism from a new perspective, develops a novel method to realize RIM and expands the applicable objects from pure organic materials to organic–inorganic hybrid materials.
Structural elucidation of ternary mixtures of L‐valine/glycyl‐L‐valine and water + 1‐decyl‐3‐methylimidazolium bromide: Apparent molar properties at infinite dilution and expansivities
Authors: Sharma Ravinder , Bahadur Indra , Katata‐Seru Lebogang , Mohammad Faruq , Singh Shailendra Kumar , Singh Prashant , Kumar Vibha 
Published: April 2024

AbstractThis work comprises ternary systems of water + SAIL,1‐decyl‐3‐methylimidazolium bromide, and (S)‐2‐Amino‐3‐methylbutanoic acid generally identified as L‐valine/ (S)‐2‐(2‐Aminoacetamido)‐3‐methylbutanoic acid usually described as glycyl‐L‐valine, densities, and sound speed data have been computed at four operating temperatures, i.e., 288.15 to 318.15 K. Calculated density data have utilized for calculation of various thermodynamic parameters like Vϕ (apparent molar volume),
(apparent molar volumes at infinite dilution), and calculated speed of sound statistics used to determine Kϕ,s (apparent molar isentropic compression), Ks (partial molar isentropic compression at infinite dilution). In our systems, the hydrophilic‐ionic interactions that are produced by co‐sphere overlap models are predominant. The Hepler's constant is used to analyze the solute's capacity to create or destroy solvent structures. The interaction parameter is computed using the McMillan‐Mayer theory. Understanding structure‐making, solvation characteristics, and numerous modifications in the ternary system of L‐valine/Glycyl‐L‐valine, water, and [C10MIm] [Br] is aided by a variety of thermodynamic factors.
Asymmetric Supercapacitors Based on ZnCo2O4 Nanohexagons and Orange Peel Derived Activated Carbon Electrodes
Authors: Haripriya M , Manimekala T , Dharmalingam Gnanaprakash , Minakshi Manickam , Sivasubramanian R. 
Published: April 2024

AbstractHerein, the performance of asymmetric supercapacitors (ASC) fabricated using ZnCo2O4 (ZCO) nano‐hexagons and orange peel‐derived activated carbon (OPAC) as electrodes was studied. ZCO was prepared by a double hydroxide method and OPAC was prepared from orange peel followed by KOH activation. For ZCO, the calcination temperature was determined using TGA analysis. The XRD showed the presence of a cubic spinel structure. The chemical structure was analyzed using XPS, FTIR, and Raman spectroscopy respectively. For OPAC, the presence of an amorphous nature was inferred; FTIR and Raman studies indicate the presence of functional groups and defect structure in the material. The presence of ZCO nano‐hexagons was observed from SEM and TEM respectively. For OPAC, an interconnected pore structure was observed from the SEM image. The specific capacitance for ZCO and OPAC was found to be 194 F.g−1 and 159 F.g−1 at a current density of 0.25 A.g−1. Further, an ASC was fabricated using ZCO as a positive and OPAC as a negative electrode in 2M KOH‐soaked separator. A cell voltage of 1.2 V was achieved and the specific capacitance was calculated to be 64 F.g−1 at 0.25 A.g−1. Further, the cyclic stability and the changes at the electrode/electrolyte interface were studied.
Gold nanoshells with varying morphologies through templated surfactant‐assisted seed‐growth method
Authors: Lee Sunghee , Lee Soyun , Hwang Soojin , Park So‐Jung 
Published: April 2024

AbstractPlasmonic nanoparticles exhibit dramatic changes in optical properties depending on their spatial organization. Therefore, the ability to precisely control their assembly structure is important for both fundamental understanding and practical applications. In this personal account, we describe a templated surfactant‐assisted seed‐growth method to synthesize core–shell‐type gold nanoparticle assemblies with controllable surface morphologies and optical properties. This approach provides a simple procedure for simultaneous growth and assembly of metal nanoparticles on polymer templates, producing well‐defined nanostructures such as spiky nanoshells and raspberry‐like metamolecules with useful and interesting optical properties, such as strong and uniform surface‐enhanced Raman scattering and metamaterial properties. We discuss the factors that control the morphology and collective properties, describe the design rules acquired from the system, and suggest future directions of this research area.
Enhancing engagement and learning in advanced biochemistry through the application of flow theory
Authors: Wu Jiafa , Wu Ying , Gu Shaobin 
Published: April 2024

AbstractThis study identified a lackluster classroom atmosphere in advanced biochemistry, characterized by low levels of active student participation in interactive communication and subpar quality of after‐class learning tasks. The issues stemmed not only from students' learning attitudes, such as insufficient attention to the curriculum, but also from the course's inherent lack of challenge. Employing flow theory, we optimized teaching content, enhanced course difficulty, reformed assessment methods, and incorporated information‐based teaching tools to redesign the instructional process. Through a questionnaire survey, students evaluated teaching effectiveness after implementation of the changes: a majority expressed satisfaction with the moderate difficulty of the course and enjoyment of the classroom instruction, and reported experiencing positive emotional flow. Peer experts commended the course, noting its lively atmosphere and the students' acquisition of both basic research methods and foundational knowledge. The findings will be used to continually enhance graduate students' innovation abilities and sense of achievement through ongoing reforms.
Assessment of prolonged proteasome inhibition through ixazomib‐based oral regimen on newly diagnosed and first‐relapsed multiple myeloma: A real‐world Chinese cohort study
Authors: Liu Aijun , Yu Hong , Hou Rui , Zhu Zunmin , Zhuang Jun‐ling , Bao Li , Li Zhenling , Liu Lihong , Hua Luoming , Ma Yanping , Gao Da , Jin Arong , Suo Xiaohui , Yang Wei , Bai Yuansong , Fu Rong , Zheng Deqiang , Chen Wenming 
Published: April 2024

AbstractObjectiveTo evaluate the effectiveness, safety, and convenience of in‐class transition (iCT) from intravenous bortezomib‐based induction to ixazomib‐based oral regimens.MethodsThis retrospective real‐world study was conducted in 16 Chinese hospitals between October 2017 and April 2023 and analyzed newly diagnosed (NDMM) and first‐line relapsed multiple myeloma (FRMM) patients who attained at least a partial response from bortezomib‐based induction therapy, followed by an ixazomib‐based oral regimen for 2 year or until disease progression or intolerable toxicity.ResultsThe study enrolled 199 patients, median age: 63 years old, male 55.4%, 53% as high risk (HR), and 47% as standard risk. Cytogenetic risk stratification by metaphase fluorescence in situ hybridization (M‐FISH), based on the Mayo Clinic risk stratification system. The median duration of total PI therapy was 11 months, with ixazomib‐based treatment spanning 6 months. At the 20‐month median follow‐up, 53% of patients remained on therapy. The 24‐month PFS rate was 84.3% from the initiation of bortezomib‐based induction and 83.4% from the start of ixazomib‐based treatment.Overall response rate (ORR) was 100% post‐bortezomib induction and 90% following 6 cycles of the ixazomib‐based regimen. Based on the Sankey diagrams, 89.51% of patients maintained or improved their disease response after 2 cycles of iCT, 6 cycles (90.14%), and 12 cycles (80%). The HR level of Mayo was found to be a significant independent factor in a worse remission (hazard ratio (HR) 2.55; p = 0.033).Ixazomib's safety profile aligned with previous clinical trial data, with 49% of patients experiencing at least one AE of any grade. The most common AEs included peripheral neuropathy, nausea and vomiting, diarrhea, thrombocytopenia, and granulocytopenia.ConclusionIn the real‐world Chinese MM population, NDMM and FRMM patients responded favorably to PI‐based continuous therapy, demonstrating substantial response rates. The ixazomib‐based iCT allows for sustained PI‐based treatment, offering promising efficacy and tolerable AEs.
Enhanced CTLA‐4 blockade anti‐tumor immunity with APG‐157 combination in a murine head and neck cancer
Authors: Shin Daniel Sanghoon , Basak Saroj , Veena Mysore S. , Comin‐Anduix Begoña , Bhattacharya Arjun , Dong Tien S. , Ko Albert , Han Philip , Jacobs Jonathan , Moatamed Neda A. , Avila Luis , Pellegrini Matteo , Wang Marilene , Srivatsan Eri S. 
Published: April 2024

AbstractBackgroundA phase I clinical study for patients with locally advanced H&N cancer with a new class of botanical drug APG‐157 provided hints of potential synergy with immunotherapy. We sought to evaluate the efficacy of the combination of APG‐157 and immune checkpoint inhibitors.MethodsCCL23, UM‐SCC1 (human), and SCCVII (HPV−), MEER (HPV+) (murine) H&N cancer cell lines were utilized for in vitro and in vivo studies. We measured tumor growth by treating the mice with APG‐157, anti‐PD‐1, and anti‐CTLA‐4 antibody combinations (8 groups). The tumor microenvironments were assessed by multi‐color flow cytometry, immunohistochemistry, and RNA‐seq analysis. Fecal microbiome was analyzed by 16S rRNA sequence.ResultsAmong the eight treatment groups, APG‐157 + anti‐CTLA‐4 demonstrated the best tumor growth suppression (p = 0.0065 compared to the control), followed by anti‐PD‐1 + anti‐CTLA‐4 treatment group (p = 0.48 compared to the control). Immunophenotype showed over 30% of CD8+ T cells in APG‐157 + anti‐CTLA‐4 group compared to 4%–5% of CD8+ T cells for the control group. Differential gene expression analysis revealed that APG‐157 + anti‐CTLA‐4 group showed an enriched set of genes for inflammatory response and apoptotic signaling pathways. The fecal microbiome analysis showed a substantial difference of lactobacillus genus among groups, highest for APG‐157 + anti‐CTLA‐4 treatment group. We were unable to perform correlative studies for MEER model as there was tumor growth suppression with all treatment conditions, except for the untreated control group.ConclusionsThe results indicate that APG‐157 and immune checkpoint inhibitor combination treatment could potentially lead to improved tumor control.
Prognostic value of preoperative combined neutrophil, monocyte, and lymphocyte scores in patients with renal cell carcinoma undergoing laparoscopic nephrectomy: A retrospective study
Authors: Ni Jinliang , Yao Xiaoxiang , Song Wei , Zhang Heng , Zhang Houliang , Wang Yidi , Zhang Yifan , Wang Guangchun , Wang Keyi , Mao Weipu , Peng Bo 
Published: April 2024

AbstractBackgroundIn a multi‐institutional clinical study, we assessed the prognostic significance of a novel indicator preoperative peripheral blood immune (PBIS) scores that combined ratios of preoperative lymphocyte, monocyte, and neutrophil of renal cell carcinoma (RCC) patients undergoing laparoscopic nephrectomy.MethodsBetween January 2014 and December 2019, 438 patients with RCC were retrospectively analyzed in three centers. We used X‐tile software to obtain the optimum cut‐off values for neutrophils, monocytes, and lymphocytes to classify the patients. To assess the relationship between PBIS score and overall survival (OS), and cancer‐specific survival (CSS) in patients with RCC by Kaplan–Meier survival curves and Cox regression analyses. In addition, predictive OS and CSS nomograms were constructed. The discriminative ability of nomogram and predictive performance accuracy were verified with consistency index (C‐index), calibration curves, receiver operating curve (ROC) curves, decision curve analysis (DCA) curves, and time‐dependent ROC curves.ResultsThe optimum cutoff values for monocytes, lymphocytes, and neutrophils were 0.46, 1.01, and 4.50, respectively. We divided patients into four subgroups according to PBIS scores, which were significantly associated with M‐stage (p = 0.008), T‐stage (p < 0.001), N‐stage (p = 0.006), and AJCC stage (p < 0.001). Multivariate Cox regression analysis revealed that RCC patients with lower PBIS scores showed a worse postoperative prognosis and served as an independent predictor of OS (p = 0.002) and CSS (p < 0.001). Ultimately, the nomograms based on PBIS scores demonstrated excellent predictive performance for OS (C‐index: 0.770) and CSS (C‐index: 0.828) through the analysis of calibration curves, ROC curves, DCA curves, and time‐dependent ROC curves.ConclusionPBIS score served as novel and effective predictor to accurately predict OS and CSS in patients with RCC receiving laparoscopic nephrectomy.
Systematic Chemical Analysis of Crude Glycan Isolates from the Seven‐Herb Decoction Quanzhenyiqitang with Anti‐COPD Activity
Authors: Yu Xiaoxian , Dai Shiting , Dai Longchao , Ao Ran , Zhang Dapeng , Wang Lingchong 
Published: April 2024

AbstractThe classical Chinese Medicine prescription, Quanzhenyiqitang (QZYQT), containing seven tonic herbs (Shudi, Dangshen, Maidong, Baizhu, Niuxi, Fuzi, and Wuweizi) is clinically used to treat chronic obstructive pulmonary disease (COPD). Although there are studies on the pharmacological effects of QZYQT, little attention has been paid to its active carbohydrate ingredients. We performed a systematic chemical analysis of the crude glycan isolates from the seven‐herb decoction (GI‐QZYQT) after confirming its anti‐COPD activity. GI‐QZYQT could enhance lung function, reduce lung damage, and alleviate inflammatory response in mice with COPD. Moreover, two monosaccharides (fructose and glucose) and six oligosaccharides (sucrose, melibiose, 1‐kestose, raffinose, mannotriose, and stachyose), accounting for 40.23 % of GI‐QZYQT, were discovered using hydrophilic interaction liquid chromatography–evaporative light‐scattering detection. Inulin‐type fructan with an average molecular weight of 2112 Da was identified using high‐performance gel‐permeation chromatography in combination with monosaccharide mapping analysis, accounting for 20.10 % of GI‐QZYQT in mass. The comparison study showed that the identified monosaccharides, oligosaccharides, and the inulin‐type fructan of GI‐QZYQT were mainly derived from herbs of Shudi, Dangshen, Maidong, Baizhu, and Niuxi. These findings provide crucial information on the chemical composition of GI‐QZYQT, which is vital for the in‐depth understanding of its bioactivity, mechanism, and product development.
Double kiss mini‐crush technique to treat complex recurrent renal artery in‐stent restenosis
Authors: Drieghe Benny , Hendrickx Ief , De Buyzere Marc , De Backer Tine 
Published: April 2024

AbstractThe double‐kiss mini‐crush (DKMC) technique has been successfully deployed in the past for the treatment of complex coronary lesions even for left main lesions. Our case report consists of a proof‐of‐principle that the DKMC technique can be successfully translated as well to the field of complex renal artery lesions. Insightful thinking out‐of‐the “coronary” box in concert with skillful off‐label application of coronary stenting procedures may open the gate for unprecedented opportunities for the treatment of difficult‐to‐tackle in‐stent restenosis in the renal circulation.
Hemophilic pseudotumor of the knee joint: Emphasizing prevention and early diagnosis in a rare disease
Authors: Devkota Shritik , Adhikari Sugat , Lamichhane Samiksha , Adhikari Dipendra , Bika Bhola , Choudhary Shayeri Roy , Bhalla Tajinder 
Published: April 2024

Key Clinical MessageHemophilic pseudotumors are rare complications occurring in individuals with severe hemophilia, characterized by progressive cystic swellings in muscles and/or bones due to recurrent bleeding. Timely initiation of factor VIII replacement is crucial.AbstractHemophilic pseudotumors are rare complications occurring in individuals with severe hemophilia, characterized by progressive cystic swellings in muscles and/or bones due to recurrent bleeding. Although their incidence has decreased with the advent of factor VIII replacement therapy, they still create challenges, particularly in regions with limited access to medical care. Here, we present a case report of a hemophilic pseudotumor of the knee joint in a 15‐year‐old male with hemophilia A. The patient presented with severe left knee pain, swelling, and restricted range of motion, prompting further investigation. Imaging studies revealed lytic lesions, and MRI bone signal changes consistent with hemophilic pseudotumors. Prompt initiation of factor VIII replacement therapy and supportive management led to a significant improvement in symptoms and joint functionality. Follow‐up after 2 months showed that the swelling had significantly reduced in size, with marked improvement in the functionality of the knee joint. This case confirms what is already known in the hemophilia literature: how important it is to prevent, diagnose, and treat pseudotumors early in hemophilia. However, longer clinical and imaging follow‐up of this case is necessary to determine whether the complaints associated with pseudotumors resolve with hematologic treatment or will require surgical treatment.