bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of a novel likely pathogenic TPM1 variant linked to hypertrophic cardiomyopathy in a family with sudden cardiac death
Authors: Azimi Amir , Soveizi Mahdieh , Salmanipour Alireza , Mozafarybazargany Mohammadhossein , Ghaffari Jolfayi Amir , Maleki Majid , Kalayinia Samira 
Published: June 2024

AbstractAimsHypertrophic cardiomyopathy (HCM) is an autosomal dominant genetic cardiac disorder characterized by unexplained left ventricular hypertrophy. It can cause a wide spectrum of clinical manifestations, ranging from asymptomatic to heart failure and sudden cardiac death (SCD). Approximately half of HCM cases are caused by variants in sarcomeric proteins, including α‐tropomyosin (TPM1). In this study, we aimed to characterize the clinical and molecular phenotype of HCM in an Iranian pedigree with SCD.Methods and ResultsThe proband and available family members underwent comprehensive clinical evaluations, including echocardiography, cardiac magnetic resonance (CMR) imaging and electrocardiography (ECG). Whole‐exome sequencing (WES) was performed in all available family members to identify the causal variant, which was validated, and segregation analysis was conducted via Sanger sequencing. WES identified a novel missense variant, c.761A>G:p.D254G (NM_001018005.2), in the TPM1 gene, in the proband, his father and one of his sisters. Bioinformatic analysis predicted it to be likely pathogenic. Clinical features in affected individuals were consistent with HCM.ConclusionsThe identification of a novel TPM1 variant in a family with HCM and SCD underscores the critical role of genetic screening in at‐risk families. Early detection of pathogenic variants can facilitate timely intervention and management, potentially reducing the risk of SCD in individuals with HCM.
Long‐term cognitive and brain morphologic changes in chronic heart failure: Results of the Cognition.Matters‐HF study
Authors: Traub Jan , Homola György , Morbach Caroline , Sell Roxanne , Göpfert Dennis , Frantz Stefan , Pham Mirko , Stoll Guido , Störk Stefan , Frey Anna 
Published: June 2024

AbstractAimsCognitive impairment (CI) is a common, yet frequently unrecognized co‐morbidity in chronic heart failure (HF). We quantified trajectories of cognitive performance, brain volume, and related clinical outcome over a time course of 6 years.Methods and resultsThe Cognition.Matters‐HF cohort study recruited patients with stable HF of any aetiology and severity. Beyond cardiological assessment, the workup included cognitive testing and brain magnetic resonance imaging (MRI). Of 148 recruited patients, 70% exhibited CI at baseline. During the median follow‐up time of 69 months (quartiles: 68, 70), indicators of HF severity remained essentially unaltered. CI was also stable, with the exception of intensity of attention, where age‐adjusted t‐scores decreased from 42 (38, 46) to 38 (34, 44; P < 0.001). Complete sets of four serial brain MRI scans were available in 47 patients (32% of total sample). Total brain volume shrank by 0.4% per year, from 1103 (1060, 1143) cm3 to 1078 (1027, 1117) cm3, which was within limits observed in non‐diseased ageing individuals. During follow‐up, 29 study participants (20%) died, and 26 (18%) were at least once hospitalized due to worsening HF. The presence of CI was not associated with overall (P = 0.290) or hospitalization‐free (P = 0.450) survival.ConclusionsIn patients with stable HF patients receiving guideline‐directed pharmacologic treatment and regular medical care, the presence of CI did not affect overall and hospitalization‐free 6‐year survival. The loss of brain parenchyma observed in patients with stable HF did not exceed that of normal ageing.
Vibration and flutter analysis of piezoelectric plates in an electrothermal field using higher order theories
Authors: Khoshgoftar Mohammad Javad 
Published: June 2024

AbstractIn this study, we investigate the vibration and dynamic stability of a thick rectangular plate that is restrained on four edges by simple clamps. Nonlocal elasticity based on high‐order shear theories is used to model the structure, which takes into account not only shear flow along the thickness, but also different distributions of shear deformations. The inclusion of rotational inertia also significantly impacts the accuracy of the results. The aerodynamic flow on the plate surface is modeled using the linear piston theory, which relates the incoming load from the aerodynamic flow to the transversal deformation of the plate. By utilizing Hamilton's principle, the governing equations for the system are obtained and solved using the weighted residual method. The results are validated by comparing them to previous studies. The effects of various parameters, such as the plate's geometrical properties, the impact of different theories, heat, electric voltage, and nonlocal variables, on the vibration and flutter behavior of the plate are examined. Additionally, it is found that the application of negative voltage increases the critical aerodynamic pressure by creating a traction force, and that a suitable thermal load can avoid instability caused by aerodynamic load. By applying voltage and heat, it is possible to increase the flutter threshold and delay it.
New concepts in the design of an IoT electric torque wrench‐based on a smart meter chip
Authors: Meng Zhaohui , Zhang Peng , Zhang Hongli , Wang Huawei 
Published: June 2024

AbstractElectric torque wrenches play a critical role in the assembly process of high‐strength bolts. This study focuses on three assembly processes for high‐strength bolts and introduces two statistical analysis methods to evaluate the quality of bolt assembly. To improve performance, a novel fully digital electric torque wrench, integrated with a smart meter chip, is designed. This wrench achieves integration between the current sensor control method and the torque sensor control method through a simplified hardware circuit, ensuring high precision and stability. Moreover, the AC voltage self‐stabilization method and Savitzky–Golay filtering method are employed in this study to enhance the accuracy and robustness of the wrench. Simulation experiments using Simulink and Matlab validate the effectiveness of these two methods. Additionally, a cloud platform is utilized to facilitate seamless connectivity and data transmission, enabling rapid Internet of Things access for the wrench.
Modeling and simulation of the control system for the plane mirror rotating interferometer
Authors: Qin Yusheng , Li Xiangxian , Han Xin , Tong Jingjing , Gao Minguang 
Published: June 2024

AbstractTo solve the problem of optical path difference velocity (OPDV) stability in the Fourier spectrometer, a Cerebellar Model Articulation Controller‐Proportional‐Integral‐Derivative (CMAC‐PID) composite control strategy is proposed. The relationship between the angular velocity of the rotary‐type voice coil motor (RT‐VCM) and the OPDV was studied, along with a mathematical model of the parallel rotating mirror interferometer system. CMAC‐PID is designed and simulated on this basis to suppress the disturbance of nonlinear factors in the system model. The simulation results demonstrate that the steady‐state fluctuation error of the CMAC‐PID controller is 90.1% less than that of the PID controller. The experimental results indicate that compared to the PID controller, the CMAC‐PID controller improves the stability of the OPDV by 1.25%, which means that time‐varying disturbances are effectively suppressed.
La sazón de liderazgo among Latine evaluators to advance LatCREE
Authors: Aponte‐Soto Lisa , Maldonado Saúl I. , Valentín Cortés Mislael A. , Neubauer Leah C. , Hernandez Arthur 
Published: June 2024

AbstractThe pool of Latine evaluators advancing to leadership is significantly narrow. Investing in the pipeline of Latine talent in the evaluation field who can authentically practice Latine Culturally Responsive and Equitable Evaluation (LatCREE) is essential for working in partnership with Latine communities, advancing theory, and the profession. This article summarizes the findings from testimonios (testimonials) with Latine evaluation líderes (leaders) in the American Evaluation Association (AEA) using a collective critical reflection approach. First, we describe the mentorship and liderazgo (leadership) experiences of Latine evaluators. We also define the central tenets for applying LatCREE as viewed through the lens of Latine evaluators as well as the challenges and lessons learned for conducting LatCREE with diverse Latine communities. Lastly, we discuss the liderazgo (leadership) characteristics that Latine evaluators recognized as being influential to their own leadership journeys as advocates of LatCREE.
The effect of social media use on mental health of college students during the pandemic
Authors: Fruehwirth Jane Cooley , Weng Alex Xingbang , Perreira Krista M. 
Published: June 2024

AbstractSocial media is viewed to be a key contributor to worsening mental health in adolescents, as most recently reflected in a public health advisory by the US Surgeon General. We provide new evidence on the causal effects of social media on mental health of college students during the Covid‐19 pandemic, exploiting unique, longitudinal data collected before the Covid‐19 pandemic began and at two points during the pandemic. We find small insignificant effects of social media 4 months into the pandemic during a period of social distancing, but large statistically significant negative effects 18 months into the pandemic when colleges were mostly back to normal operations. Using rich data on substance use, exercise, sleep, stress, and social support, we find some evidence of substitution away from activities that better support mental health at later stages of the pandemic but not at early stages. We find that the negative effects of social media are mostly concentrated among socially‐isolated students. Both social support and resilience protect students from the negative effects of social media use. Policy implications include regulating social media while also bolstering social support and resilience as important protective factors.
Fatigue in rheumatoid arthritis patients: The status, independent risk factors, and consistency of multiple scales
Authors: Zhou Jun , Wang Wen , Gao Wenjia , Xu Yan , Zang Yinshan 
Published: June 2024

AbstractIntroductionFatigue is a common symptom that negatively affects the outcomes and functions of rheumatoid arthritis (RA) patients. This study aimed to assess the fatigue by two scales and validate their consistency, also to comprehensively evaluate fatigue‐related risk factors in RA patients.MethodsIn this case–control study, the fatigue of 160 RA patients and 60 healthy controls was evaluated by the Bristol Rheumatoid Arthritis Fatigue Multi‐Dimensional Questionnaire (BRAF‐MDQ) and the Chinese version of the Brief Fatigue Inventory (BFI‐C). The 28‐joint disease activity score using erythrocyte sedimentation rate of RA patients was assessed.ResultsThe BRAF‐MDQ and BFI‐C scores were elevated in RA patients versus healthy controls (all p < .001). Interestingly, BRAF‐MDQ global fatigue score positively correlated with BFI‐C global fatigue score in both RA patients (r = .669, p < .001) and healthy controls (r = .527, p < .001); meanwhile, Kendall's tau‐b test showed a high consistency between BRAF‐MDQ and BFI‐C global fatigue scores in RA patients (W = 0.759, p < .001) and healthy controls (W = 0.933, p < .001). Notably, higher education level (В = −4.547; 95% confidence interval: −7.065, −2.029; p < .001) and swollen joint count (В = 1.965; 95% confidence interval: 1.375, 2.554; p < .001) independently related to BRAF‐MDQ global fatigue score; higher education level (В = −0.613; 95% confidence interval: −0.956, −0.269; p = .001) and clinical disease activity index (В = 0.053; 95% confidence interval: 0.005, 0.102; p = .032) independently linked with BFI‐C global fatigue score.ConclusionFatigue commonly occurs in RA patients, which independently relates to education level and disease activity. Furthermore, BRAF‐MDQ and BFI‐C scales exhibit a high consistency in assessing fatigue.
Customizable, biocompatible implants for dorsal nasal augmentation: An in vivo pilot study of eight polylactic acid scaffold designs
Authors: O'Connell Gillian M. , Vernice Nicholas , Matavosian Alicia A. , Slyker Leigh , Bender Ryan J. , Dong Xue , Bonassar Lawrence J. , Shin James , Spector Jason A. 
Published: June 2024

AbstractAugmentation of the nasal dorsum often requires implantation of structural material. Existing methods include autologous, cadaveric or alloplastic materials and injectable hydrogels. Each of these options is associated with considerable limitations. There is an ongoing need for precise and versatile implants that produce long‐lasting craniofacial augmentation. Four separate polylactic acid (PLA) dorsal nasal implant designs were 3D‐printed. Two implants had internal PLA rebar of differing porosities and two were designed as “shells” of differing porosities. Shell designs were implanted without infill or with either minced or zested processed decellularized ovine cartilage infill to serve as a “biologic rebar”, yielding eight total treatment groups. Scaffolds were implanted heterotopically on rat dorsa (N = 4 implants per rat) for explant after 3, 6, and 12 months followed by volumetric, histopathologic, and biomechanical analysis. Low porosity implants with either minced cartilage or PLA rebar infill had superior volume retention across all timepoints. Overall, histopathologic and immunohistochemical analysis showed a resolving inflammatory response with an M1/M2 ratio consistently favoring tissue regeneration over the study course. However, xenograft cartilage showed areas of degradation and pro‐inflammatory infiltrate contributing to volume and contour loss over time. Biomechanical analysis revealed all constructs had equilibrium and instantaneous moduli higher than human septal cartilage controls. Biocompatible, degradable polymer implants can induce healthy neotissue ingrowth resulting in guided soft tissue augmentation and offer a simple, customizable and clinically‐translatable alternative to existing craniofacial soft tissue augmentation materials. PLA‐only implants may be superior to combination PLA and xenograft implants due to contour irregularities associated with cartilage degradation.
Molecular epidemiology and risk factors associated with BK and JC polyomavirus urinary shedding after kidney allograft
Authors: Demey Baptiste , Aubry Aurélien , Descamps Véronique , Morel Virginie , Le My Hanh Hillary , Presne Claire , Brazier François , Helle François , Brochot Etienne 
Published: June 2024

AbstractPolyomaviruses BK (BKPyV) and JC (JCPyV), belonging to the Polyomaviridae, are responsible for human pathologies. In kidney transplant recipients, BKPyV replication can lead to irreversible nephron damage whereas JCPyV replication remains asymptomatic. Concomitant replication is rare and potential competition between the infections has been described. The aim of this retrospective case‐control study was to describe the molecular epidemiology and risk factors associated with BKPyV and JCPyV replication in a cohort of kidney transplant recipients. In total, 655 urine samples from 460 patients were tested for BKPyV and JCPyV DNA. Positive samples were submitted to strain genotyping. Demographic and clinical characteristics were also compared. Isolated JCPyV and BKPyV was found in 16.5% and 23.3% of patients, respectively; co‐replication was rare (3.9%). BKPyV strains Ib‐2, Ib‐1, and IVc‐2 were the most prevalent. JCPyV strains mostly belonged to genotypes 4 and 1B. During follow‐up, JCPyV shedding significantly reduced the risk of BKPyV DNAuria, with an odds ratio of 0.57 (95% confidence interval: 0.35–0.99), and was associated with better prognosis than BKPyV replication, based on the estimated glomerular filtration rate. Molecular epidemiology of BKPyV and JCPyV strains in our region was similar to previous studies. This study suggests that JCPyV is benign and appears to limit damaging BKPyV replication. JCPyV DNAuria screening could thus be a useful strategy to predict BKPyV‐related outcomes.
‘You can be as vigilant as you can, yet they make their way in’: A descriptive study of parent and caregiver perspectives towards keeping children safe from button batteries
Authors: Girardi Anna M. , Long David N. , Austin Gavin 
Published: June 2024

AbstractObjectivesButton batteries pose a significant threat to young children, and parents and caregivers play an important role in keeping children safe from button batteries, especially in the home environment. However, little is known regarding parent or caregiver perspectives on button battery safety, in particular, the threat they pose to children. The aim of this study was to examine perspectives on button battery safety to enable tailored prevention strategies and to examine parent and caregiver perspectives on button battery safety in the home.MethodsOne hundred and seventy‐four parents and caregivers of children aged 0–5 completed a cross‐sectional online survey. Distribution occurred via social media. The survey contained multiple‐choice questions pertaining to button battery knowledge and attitudes.ResultsMost respondents recognised the dangers of button battery ingestion, yet only 37% knew of button battery ingestion symptoms. While 68% knew of household items containing button batteries, 21% were aware of product‐recall information sources. Approximately 64% understood immediate post‐ingestion steps, but only 31% were familiar with first‐aid procedures. From an attitudinal standpoint, 95% understood the importance of child supervision around button batteries, 78% prioritised battery safety in toy purchases, and 17% found current safety labels unsatisfactory. This study provides a foundation for ongoing investigation of parent and caregiver perspectives on button battery home safety.ConclusionOngoing, comprehensive education and public‐safety campaigns are needed to rectify gaps in knowledge regarding button battery safety, and to reduce the risk of button battery ingestion in children.
Incidence and geographic differences in keratinocyte carcinoma and Bowen's disease in office‐based dermatological practice between 2013 and 2022: A nationwide Danish registry‐based study
Authors: Sieborg Johan , Haedersdal Merete , Lei Ulrikke , Sølvsten Henrik , Olesen Anne Braae , Vinding Gabrielle Randskov , Lamberg Anna Lei , Egeberg Alexander , Wenande Emily 
Published: June 2024

AbstractBackgroundRates of keratinocyte carcinoma (KC) across Europe are impacted by population demographics and geography. Regional differences in KC occurrence exist, but few European studies investigate incidences of specific subtypes in the secondary healthcare sector on a national level.ObjectivesTo determine geographical differences in incidence rate and lifetime risk of KC subtypes across Denmark, including nodular and superficial basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and the KC precursor, Bowen's disease (BD), identified in office‐based dermatological practice.MethodsBased on a nationwide registry (The Danish Skin Cancer Registry), all patients in Denmark's five regions with a histologically‐ or clinically verified KC or BD registered in a state‐funded office‐based dermatology practice between 2013 and 2022 were included. Trends in national‐ and region‐specific age and sex standardised tumour incidence rates (STIR) were calculated. Further, national lifetime risk of each tumour subtype was estimated.ResultsBetween 2013 and 2022, the combined STIR for KC/BD rose 172% nationally from 180 to 489 per 100,000 person‐years (PY). This increase reflected rising rates of nodular BCC, SCC, and BD, while superficial BCC incidence was relatively stable. Regional differences in STIR for combined KC/BD were observed, with the Capital Region and North Jutland generally demonstrating higher rates than Zealand, Southern‐ and Central Denmark (e.g., North Jutland vs. Southern Denmark: 714 vs. 405/100,000PY). While the estimated lifetime risk of developing at least one KC or BD tumour was 21.8%, risk varied with tumour subtype, resulting in subtype‐specific risks of 16.4%, 5.1%, 1.9% and 1.3% for nodular BCC, superficial BCC, SCC, and BD, respectively.ConclusionsIn Denmark's secondary dermatological care sector, incidence of nodular BCC, SCC and BD continues to rise with an overall lifetime risk nearing 22%. While KC incidence is increasing in Denmark, the study detected differences in geographical trends and rate increases of specific tumour subtypes.
Designing count‐based studies in a world of hierarchical models
Authors: Latif Quresh S. , Valente Jonathon J. , Johnston Alison , Davis Kayla L. , Fogarty Frank A. , Green Adam W. , Jones Gavin M. , Leu Matthias , Michel Nicole L. , Pavlacky David C. , Rigby Elizabeth A. , Rushing Clark S. , Sanderlin Jamie S. , Tingley Morgan W. , Zhao Qing 
Published: June 2024

AbstractAdvances in hierarchical modeling have improved estimation of ecological parameters from count data, especially those quantifying population abundance, distribution, and dynamics by explicitly accounting for observation processes, particularly incomplete detection. Even hierarchical models that account for incomplete detection, however, cannot compensate for data limitations stemming from poorly planned sampling. Ecologists therefore need guidance for planning count‐based studies that follow established sampling theory, collect appropriate data, and apply current modeling approaches to answer their research questions. We synthesize available literature relevant to guiding count‐based studies. Considering the central historical and ongoing contributions of avian studies to ecological knowledge, we focus on birds as a case study for this review, but the basic principles apply to all populations whose members are sufficiently observable to be counted. The sequence of our review represents the thought process in which we encourage ecologists to engage 1) the research question(s) and population parameters to measure, 2) sampling design, 3) analytical framework, 4) temporal design, and 5) survey protocol. We also provide 2 hypothetical demonstrations of these study plan components representing different research questions and study systems. Mirroring the structure of hierarchical models, we suggest researchers primarily focus on the ecological processes of interest when designing their approach to sampling, and wait to consider logistical constraints of data collection and observation processes when developing the survey protocol. We offer a broad framework for researchers planning count‐based studies, while pointing to relevant literature elaborating on particular tools and concepts.