bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Synthesis of Novel 6,6a,7,8‐Tetrahydro‐5H‐naphtho[1,2‐e]pyrimido[4,5‐b][1,4]diazepines under Microwave Irradiation as Potential Antitumor Agents.
Authors: Insuasty Braulio , Garcia Angelica , Quiroga Jairo , Abonia Rodrigo , Nogueras Manuel , Cobo Justo 
Published: September 2010

AbstractChemical synthesis and antitumor activity are described.
ChemInform Abstract: Palladium‐Mediated Reductive Mizoroki—Heck Cyclization Strategy for the Regioselective Formation of Dibenzoazocinone Framework.
Authors: Majumdar K. C. , Ghosh Tapas , Chakravorty Santanu 
Published: September 2010

AbstractOptimized conditions provide the title compounds (II) and (IV) as potential biologically active frameworks.
ChemInform Abstract: Design, Synthesis and SAR of Phenylamino‐Substituted 5,11‐Dihydrodibenzo[a,d]cyclohepten‐10‐ones and 11H‐Dibenzo[b,f]oxepin‐10‐ones as p38 MAP Kinase Inhibitors.
Authors: Dorn Angelika , Schattel Verena , Laufer Stefan 
Published: September 2010

AbstractA series of 28 title compounds of type (III) and (V) is prepared as p38 MAP kinase inhibitors.
ChemInform Abstract: Modular Synthesis of Polybenzo[b]silole Compounds for Hole‐Blocking Material in Phosphorescent Organic Light Emitting Diodes.
Authors: Ilies Laurean , Sato Yoshiharu , Mitsui Chikahiko , Tsuji Hayato , Nakamura Eiichi 
Published: September 2010

AbstractA series of conjugated molecules containing multiple benzosilole units are synthesized and utilized as efficient hole‐blocking materials for phosphorescent OLEDs.
ChemInform Abstract: Iron‐Catalyzed, Directed Oxidative Arylation of Olefins with Organozinc and Grignard Reagents.
Authors: Ilies Laurean , Okabe Jun , Yoshikai Naohiko , Nakamura Eiichi 
Published: September 2010

AbstractThe reaction is catalyzed by Fe(acac)3 mostly without any ligand.
ChemInform Abstract: Studies on New Phytochemicals. Part 72. New Diterpenoids from Caesalpinia Species and Their Cytotoxic Activity
Authors: Das Biswananth , Srinivas Yallamalla , Sudhakar Chithaluri , Mahender Ibram , Laxminarayana Keetha , Reddy Parigi Raghavendar , Raju Tuniki Venugopal , Jakka Naga Mahesh , Rao Janapala Venkateswara 
Published: September 2010

Abstractisolation, structure elucidation and cytotoxicity
ChemInform Abstract: The Use of Ultrastable Y Zeolites in the Ferrier Rearrangement of Acetylated and Benzylated Glycals.
Authors: Levecque Pieter , Gammon David W. , Jacob Pierre , De Vos Dirk , Sels Bert 
Published: September 2010

AbstractZeolite CBV‐720 is an efficient catalyst for the Ferrier rearrangement of glycals (I) with a variety of nucleophiles.
ChemInform Abstract: Synthesis of gem‐Difluoromethylenated Analogues of Anamarine.
Authors: Lin Jing , Qiu Xiao‐Long , Qing Feng‐Ling 
Published: September 2010

AbstractA novel difluorinated anamarine derivative (IX) is prepared via indium mediated difluoropropargylation of aldehyde, obtained by oxidation of alcohol (II), and TEMPO‐catalyzed oxidative cyclization of diol (VI) as key steps.
ChemInform Abstract: Oxytrofalcatins A (Ia)—F (IV), N‐Benzoylindole Analogues from the Roots of Oxytropis falcata (Leguminosae).
Authors: Chen Wen‐Hao , Wu Quan‐Xiang , Wang Rui , Shi Yan‐Ping 
Published: September 2010

AbstractPrelimnary in vitro tests for cytotoxicity reveal that all components are inactive.
ChemInform Abstract: Bisnicalaterines B and C, Atropisomeric Bisindole Alkaloids from Hunteria zeylanica, Showing Vasorelaxant Activity.
Authors: Morita Hiroshi , et al. et al. 
Published: September 2010

AbstractThe structures of bisnicalaterines B (I) and its atropisomer are determined by spectroscopic means and computational methods.
ChemInform Abstract: Total Synthesis of Enantiopure Phalarine via a Stereospecific Pictet—Spengler Reaction: Traceless Transfer of Chirality from L‐Tryptophan.
Authors: Trzupek John D. , Lee Dongjoo , Crowley Brendan M. , Marathias Vasilios M. , Danishefsky Samuel J. 
Published: September 2010

AbstractThe total synthesis of (V) is achieved with the construction of the intermediate (IV) with complete diastereoselectivity as a key step.
ChemInform Abstract: Synthesis and Glycosidase Inhibition of the Enantiomer of (‐)‐Steviamine, the First Example of a New Class of Indolizidine Alkaloid.
Authors: Hu Xiang‐Guo , Batholomew Barbara , Nash Robert J. , Wilson Francis X. , Fleet George W. J. , Nakagawa Shinpei , Kato Atsushi , Jia Yue‐Mei , van Well Renate , Yu Chu‐Yi 
Published: September 2010

AbstractWeak inhibitory activity is found for (+)‐I, its C‐5 epimer and natural (‐)‐(I).
ChemInform Abstract: Design, Synthesis and Antiproliferative Activity of Styryl Lactones Related to (+)‐Goniofufurone.
Authors: Popsavin Velimir , Sreco Bojana , Benedekovic Goran , Francuz Jovana , Popsavin Mirjana , Kojic Vesna , Bogdanovic Gordana 
Published: September 2010

AbstractThe synthesis of (+)‐goniofufurone‐related compounds (III), (IX), (XI), and (XII) is described.
ChemInform Abstract: Novel Bisstyryl Derivatives of Bakuchiol: Targeting Oral Cavity Pathogens.
Authors: Reddy Mallepally V. , Thota Niranjan , Sangwan Payare L. , Malhotra Pankaj , Ali Furqan , Khan Inshad A. , Chimni Swapandeep S. , Koul Surrinder 
Published: September 2010

AbstractBakuchiol derivatives (III), (VI), and (VIII) are obtained via Heck and oxidative Heck coupling reaction, respectively.
ChemInform Abstract: Synthesis and Biological Evaluation of a Novel Series of 2,2‐Bisaminomethylated Aurone Analogues as Antiinflammatory and Antimicrobial Agents.
Authors: Bandgar Babasaheb P. , Patil Sachin A. , Korbad Balaji L. , Biradar Satish C. , Nile Shivraj N. , Khobragade Chandrahasya N. 
Published: September 2010

AbstractThe 2,2‐bisaminomethylated aurone analogues (IV) are obtained for the first time.
ChemInform Abstract: Formal Synthesis of (‐)‐Neopeltolide Featuring a Highly Stereoselective Oxocarbenium Formation/Reduction Sequence.
Authors: Martinez‐Solorio Dionicio , Jennings Michael P. 
Published: September 2010

AbstractThe synthesis of macrolactone (IV) as precursor of unnatural neopeltolide is achieved via allylation of lactone (I) and subsequent stereoselective reduction of an oxocarbenium compound, generated in situ.
ChemInform Abstract: Synthesis and Biological Activity of 2‐(Trifluoromethyl)‐1H‐benzimidazole Derivatives Against Some Protozoa and Trichinella spiralis.
Authors: Hernandez‐Luis Francisco , Hernandez‐Campos Alicia , Castillo Rafael , Navarrete‐Vazquez Gabriel , Soria‐Arteche Olivia , Hernandez‐Hernandez Manuel , Yepez‐Mulia Lilian 
Published: September 2010

AbstractTitle compounds (I) are evaluated in vitro against various protozoan parasites (Giardia intestinalis, Entamoeba histolytica, Trichomonas vaginalis, Leishmania mexicana) and the nematode Trichinella spiralis.
ChemInform Abstract: Synthesis of Novel Peptidomimetics as Inhibitors of Protozoan Cysteine Proteases Falcipain‐2 and Rhodesain.
Authors: Ettari Roberta , Zappala Maria , Micale Nicola , Schirmeister Tanja , Gelhaus Christoph , Leippe Matthias , Evers Astrid , Grasso Silvana 
Published: September 2010

AbstractNovel peptidomimetics of type (I) are supplied with a protected aspartyl aldehyde moiety to increase lipophilicity.
ChemInform Abstract: A Non‐Empirical Chromophoric Interpretation of CD Spectra of DNA G‐Quadruplex Structures.
Authors: Masiero Stefano , Trotta Roberta , Pieraccini Silvia , De Tito Stefano , Perone Rosaria , Randazzo Antonio , Spada Gian Piero 
Published: September 2010

AbstractReview: 60 refs.
Chirality induced by microaggregation of regioregular polythiophenes with side‐chain optically active substituent
Authors: Salatelli Elisabetta , Angiolini Luigi , Brazzi Alice 
Published: September 2010

AbstractTwo novel optically active terthiophene and bithiophene monomers bearing at the C‐β position of thiophene ring an enantiomerically pure chiral alkyl group, namely 3,3″‐di[2‐((S)‐(+)‐2‐methylbutoxy)ethyl]‐2,2′:5′,2″‐terthiophene and 3,3′‐di[2‐((S)‐(+)‐2‐methylbutoxy)ethyl]‐2:2′‐bithiophene, have been synthesized and characterized. Being symmetrically substituted, their polymerization adopting simple and economic method, such as the chemical oxidation with iron (III) trichloride, allowed to obtain regioregular macromolecules. The synthesized polymers have been investigated by CD in solution as well as in the microaggregated state upon gradual addition of a poor solvent. The results display different CD behaviors related to their chemical structure. Chirality, 2010. © 2010 Wiley‐Liss, Inc.
Performance analysis of single‐phase, multiphase, and multicomponent lattice‐Boltzmann fluid flow simulations on GPU clusters
Authors: Myre J. , Walsh S. D. C. , Lilja D. , Saar M. O. 
Published: September 2010

AbstractThe lattice‐Boltzmann method is well suited for implementation in single‐instruction multiple‐data (SIMD) environments provided by general purpose graphics processing units (GPGPUs). This paper discusses the integration of these GPGPU programs with OpenMP to create lattice‐Boltzmann applications for multi‐GPU clusters. In addition to the standard single‐phase single‐component lattice‐Boltzmann method, the performances of more complex multiphase, multicomponent models are also examined. The contributions of various GPU lattice‐Boltzmann parameters to the performance are examined and quantified with a statistical model of the performance using Analysis of Variance (ANOVA). By examining single‐ and multi‐GPU lattice‐Boltzmann simulations with ANOVA, we show that all the lattice‐Boltzmann simulations primarily depend on effects corresponding to simulation geometry and decomposition, and not on the architectural aspects of GPU. Additionally, using ANOVA we confirm that the metrics ofEfficiencyandUtilizationare not suitable for memory‐bandwidth‐dependent codes. Copyright © 2010 John Wiley & Sons, Ltd.
HOx Regeneration in the Oxidation of Isoprene III: Theoretical Study of the key Isomerisation of the Z‐δ‐hydroxy‐peroxy Isoprene Radicals
Authors: Nguyen Thanh Lam , Vereecken Luc , Peeters Jozef 
Published: September 2010

AbstractAs a sequel to our communication on a proposed new isoprene oxidation mechanism aiming to rationalize the unexpectedly high OH and HO2 levels observed in isoprene‐rich areas (J. Peeters, T. L. Nguyen, L. Vereecken, Phys. Chem. Chem. Phys. 2009, 11, 5935), we report herein the detailed quantum chemical and statistical kinetics characterization of the crucial 1,6‐H shifts in the two Z‐δ‐hydroxy‐peroxy radicals from isoprene. Geometries, energies and vibration frequencies of all conformers of the reactant radicals and transition states are computed at the B3LYP/6‐31+G(d,p) level of theory and the energies of the lowest‐lying conformers are then refined at various higher levels of theory, including CBS‐QB3, IRCMax(CBS‐QB3//B3LYP) and CBS‐APNO. The rate coefficients over a wide temperature range are calculated using multi‐conformer transition state theory with WKB tunneling factors evaluated for the barrier shape found by CBS‐QB3//B3LYP IRC analyses. The WKB tunneling factors for these allyl‐stabilisation‐assisted reactions are about 25 at ambient temperatures. The rate coefficients can be represented by Arrhenius expressions over the 250–350 K range: k(T)=1.4×109 exp(−6380/T) s−1 for the Z‐1‐OH‐4‐OO⋅‐isoprene radical, and k(T)=0.72×109 exp(−5520/T) s−1 for Z‐1‐OH‐4‐OO⋅‐isoprene. With the k(1,6‐H) of order 1 s−1 at ambient temperatures, these isomerisations can compete with and even outrun the traditional peroxy reactions at low and moderate NO levels. The importance of these reactions as key processes in the newly proposed, OH‐regenerating isoprene oxidation scheme is discussed.
Novel single‐platform multiparameter FCM analysis of apoptosis: Significant differences between wash and no‐wash procedure
Authors: Stemberger Julia , Witt Volker , Printz Dieter , Geyeregger René , Fritsch Gerhard 
Published: September 2010

AbstractFCM is a generally accepted tool to analyze apoptosis. Unfortunately, the cell preparation of all commercial kits available includes cell washing known to cause cell loss which is most likely to affect apoptotic cells in particular. To address this, we developed a seven‐color single‐platform no‐wash analysis technique and compared the results with those from an analogous procedure including cell washing. A five‐color mAb cocktail was employed to address target cells by surface labeling, Yo‐PRO‐1® and DAPI were used to discriminate apoptotic and necrotic from viable cells. Cells were quantified on the basis of internal‐standard fluorescent beads. Jurkat cells ACC 282 treated with camptothecin were employed to establish the staining procedure, which was then applied to blood cells collected by extracorporeal apheresis and treated with UV irradiation. Data evaluation showed that although each method by itself was highly reproducible (R2 = 0.973), the numbers of apoptotic cells detected with the no‐wash procedure were significantly higher than those obtained after cell washing (P = 6.6 E−5, Wilcoxon Test). In addition, the observed differences increased with higher cell numbers (Bland and Altmann). We conclude that the described test is a feasible and reliable tool for apoptosis measurement and it provides results that are definitely closer to the truth than those obtained from kits that require cell washing. © 2010 International Society for Advancement of Cytometry
The use of lectins as markers for differentiated secretory cells in planarians
Authors: Zayas Ricardo M. , Cebrià Francesc , Guo Tingxia , Feng Junjie , Newmark Phillip A. 
Published: September 2010

AbstractFreshwater planarians have reemerged as excellent models to investigate mechanisms underlying regeneration. The introduction of molecular tools has facilitated the study of planarians, but cell‐ and tissue‐specific markers are still needed to examine differentiation of most cell types. Here we report the utility of fluorescent lectin‐conjugates to label tissues in the planarian Schmidtea mediterranea. We show that 16 lectin‐conjugates stain planarian cells or tissues; 13 primarily label the secretory cells, their cytoplasmic projections, and terminal pores. Thus, we examined regeneration of the secretory system using lectin markers and functionally characterized two genes expressed in the secretory cells: marginal adhesive gland‐1 (mag‐1) and Smed‐reticulocalbin1 (Smed‐rcn1). RNAi knockdown of these genes caused a dramatic reduction of secretory cell lectin staining, suggesting a role for mag‐1 and Smed‐rcn1 in secretory cell differentiation. Our results provide new insights into planarian secretory system regeneration and add new markers for labeling several planarian tissues. Developmental Dynamics 239:2888–2897, 2010. © 2010 Wiley‐Liss, Inc.
Unusually Large Bite Angle of a Distally Diphosphanylated Calix[4]arene Chelator
Authors: Sameni Soheila , Jeunesse Catherine , Awada Mouhamad , Matt Dominique , Welter Richard 
Published: September 2010

Abstract5,17‐Diphenylphosphanyl‐11,23‐bis(4‐tolyl)‐25,26,27,28‐tetrapropoxycalix[4]arene (6), a semi‐rigid, calixarene‐based diphosphane in which the phosphorus atoms are separated by 12 chemical bonds, reacts with [Ni(η5‐C5H5)(1,5‐cyclooctadiene)]BF4 or AgBF4 to afford the corresponding chelate complexes [Ni(η5‐C5H5)(6)]BF4 and [Ag(6)]BF4 quantitatively. These complexes were both characterised by a single‐crystal X‐ray diffraction study. In the nickel complex the ligand shows a bite angle of 104.5°, which lies in the range expected for this kind of diphosphane with a large P···P separation. In the silver(I) complex the diphosphane displays a much larger bite angle of 138.8°, which was unexpected and reflects the flexilibilty of the calix[4]arene skeleton. Furthermore, in solution the silver complex shows dynamic behaviour. One of the observed motions corresponds to the silver atom switching reversibly from a linear to a bent AgP2 cordination geometry.
Total Synthesis of Berkeleyamide A and its 10‐epi Isomer
Authors: Chakor Narayan S. , Dallavalle Sabrina , Scaglioni Leonardo , Merlini Lucio 
Published: September 2010

AbstractA short and efficient synthesis of the novel cytotoxic natural product berkeleyamide A, isolated from a deep‐water Penicillium rubrum, has been accomplished. L‐Leucinol was used as the only chiral starting material. A diastereoselective aldol condensation is the key step in the synthesis.
A proteomic approach based on multiple parallel separation for the unambiguous identification of an antibody cognate antigen
Authors: Mun Joohee , Kim Yong‐Hak , Yu Jonghan , Bae Jinhee , Noh Dong‐Young , Yu Myeong‐Hee , Lee Cheolju 
Published: September 2010

AbstractAutoantibodies obtained from cancer patients have been identified as useful tools for cancer diagnostics, prognostics, and as potential targets for immunotherapy. Serological proteome analysis in combination with 2‐DE is a classic strategy for identification of tumor‐associated antigens in the serum of cancer patients. However, serological proteome analysis cannot always indicate the true antigen out of a complex proteome identified from a single protein spot because the most abundant protein is not always the most antigenic. To address this problem, we utilized multiple parallel separation (MPS) for proteome separation. The common identities present in the fractions obtained using different separation methods were regarded as the true antigens. The merit of our MPS technique was validated using anti‐ARPC2 and anti‐PTEN antibodies. Next, we applied the MPS technique for the identification of glycyl‐tRNA synthetase as the cognate antigen for an autoantibody that was overexpressed in the plasma of breast cancer patients. These results reveal that MPS can unambiguously identify an antibody cognate antigen by reducing false‐positives. Therefore, MPS could be used for the characterization of diagnostic antibodies raised in laboratory animals as well as autoantibodies isolated from diseased patients.
Genotoxic effects of three selected black toner powders and their dimethyl sulfoxide extracts in cultured human epithelial A549 lung cells in vitro
Authors: Gminski Richard , Decker Katharina , Heinz Christina , Seidel Albrecht , Könczöl Mathias , Goldenberg Ella , Grobéty Bernard , Ebner Winfried , Gieré Reto , Mersch‐Sundermann Volker 
Published: September 2010

AbstractUntil now, the adverse effects of toner powders on humans have been considered to be minimal. However, several recent reports have suggested possible significant adverse health effects from toner dust inhalation. The aim of this study was to evaluate the genotoxic potential of black toner powders in vitro. For the study of DNA damage, A549 cells were exposed to toner‐powder suspensions and to their DMSO extracts, and then subjected to the comet assay and to the in‐vitro cytokinesis block micronucleus test (CB‐MNvit). Cytotoxic effects of the toner samples were assessed by the erythrosin B assay. Furthermore, size, shape, and composition of the toner powders were investigated. None of the three toner powders or their DMSO extracts reduced cell viability; however, they did induce DNA damage and formed micronuclei at concentrations from 80 to 400 μg cm−2, although to a varying extent. All toner powders contain considerable amounts of the pigments carbon black and magnetite (Fe3O4) as well as small amounts of polycyclic aromatic hydrocarbons (PAHs). The overall results of our in‐vitro study suggest that the investigated toner‐powder samples are not cytotoxic but genotoxic. From the results of the physical and chemical characterization, we conclude that metals and metalloids as components of magnetite, or PAHs as components of the carbon‐bearing material, are responsible for the genotoxic effects. Further research is necessary to determine the relevance of these in‐vitro observations for private and occupational toner powder exposure. Environ. Mol. Mutagen., 2011. © 2010 Wiley‐Liss, Inc.
Strong ground motion record selection for the reliable prediction of the mean seismic collapse capacity of a structure group
Authors: Ghafory‐Ashtiany Mohsen , Mousavi Mehdi , Azarbakht Alireza 
Published: September 2010

AbstractHow to select a limited number of strong ground motion records (SGMRs) is an important challenge for the seismic collapse capacity assessment of structures. The collapse capacity is considered as the ground motion intensity measure corresponding to the drift‐related dynamic instability in the structural system. The goal of this paper is to select, from a general set of SGMRs, a small number of subsets such that each can be used for the reliable prediction of the mean collapse capacity of a particular group of structures, i.e. of single degree‐of‐freedom systems with a typical behaviour range. In order to achieve this goal, multivariate statistical analysis is first applied, to determine what degree of similarity exists between each selected small subset and the general set of SGMRs. Principal Component analysis is applied to identify the best way to group structures, resulting in a minimum number of SGMRs in a proposed subset. The structures were classified into six groups, and for each group a subset of eight SGMRs has been proposed. The methodology has been validated by analysing a first‐mode‐dominated three‐storey‐reinforced concrete structure by means of the proposed subsets, as well as the general set of SGMRs. The results of this analysis show that the mean seismic collapse capacity can be predicted by the proposed subsets with less dispersion than by the recently developed improved approach, which is based on scaling the response spectra of the records to match the conditional mean spectrum. Copyright © 2010 John Wiley & Sons, Ltd.
Investigating the impact of organizational culture on supply chain integration
Authors: Braunscheidel Michael J. , Suresh Nallan C. , Boisnier Alicia D. 
Published: September 2010

AbstractSupply chain integration constitutes the major thrust of supply chain management initiatives. In this study, we investigate the effects of organizational culture to determine the types of cultural characteristics that are strongly associated with efforts to integrate the supply chain and delivery performance. Previous researchers have theorized and demonstrated that organizational culture leads to adopting management practices consistent with the culture and that these practices are associated with firm performance. There has been a relative dearth of research, however, on the impact of organizational culture in operations management literature. Thus, this study investigates the effects of organizational culture, measured by the competing values framework (CVF), on two types of supply chain integration efforts: (1) internal integration and (2) external integration with key suppliers and key customers. Employing the CVF, we assess organizational culture along four dimensions—market, hierarchy, clan, and adhocracy. Results indicate that culture does influence firms to adopt internal and external integration practices. Our findings also provide evidence that a firm's adhocracy culture score is positively associated with external integration, while a firm's hierarchy culture score is negatively associated with both internal and external integration practices. © 2010 Wiley Periodicals, Inc.