bluuebunny/crossref_metadata_2025_split huggingface dataset:
Planning with parents for seriously ill children: Preliminary results on the development of the parental engagement scale
Authors: Kearney Joan A. , Byrne Mary W. 
Published: November 2011

AbstractObjective:The objective of this study was to develop a clinically relevant tool to assess parental engagement in decision making and planning for seriously ill children during palliative care consultations. Although little is known about the structure and process of planning meetings between parents and providers, less is known about the nature of parental engagement as it relates to decision making ability in pediatric end-of-life care. Using attachment and caregiving as a framework, this study clarified important dimensions of parental engagement.Method:Using a multi-phase, template-matching technique, both literature and pediatric palliative care consultation data were analyzed, iteratively reviewed, matched, and categorized to create a measure of parental engagement. The attachment paradigm serves as the theoretical framework for the study, which focuses on parental engagement in decision making as a caregiving system function. Attachment and related literatures as well as coping and pediatric palliative care literatures were used in the initial conceptual sampling phase.Results:The study yielded two groups of findings. The first set of findings centered on the findings of the literature and consultation template-matching phases of the work. These two phases yielded a conceptual model of parental engagement as a psychobehavioral complex consisting of three dimensions: information-centered dialogue, insightful participation, and achievement of a collaboratively agreed-upon plan. The final phases consisted of creation of a 9 point Parental Engagement Scale, scoring of the consultations, and establishment of initial inter- rater reliability at .80. Psychometric testing continues.Significance of results:Parental engagement in decision making is a critical area for study and intervention. If we can support parents in their caregiving executive functions while understanding the psychological and emotional underpinnings of the caregiving system and parental engagement itself, we can move inquiry forward in understanding parental needs for intervention during this most profoundly challenging time.
MESSENGER and Mariner 10 flyby observations of magnetotail structure and dynamics at Mercury
Authors: Slavin James A. , Anderson Brian J. , Baker Daniel N. , Benna Mehdi , Boardsen Scott A. , Gold Robert E. , Ho George C. , Imber Suzanne M. , Korth Haje , Krimigis Stamatios M. , McNutt Ralph L. , Raines Jim M. , Sarantos Menelaos , Schriver David , Solomon Sean C. , Trávníček Pavel , Zurbuchen Thomas H. 
Published: November 2011

The first (M1), second (M2), and third (M3) MESSENGER flybys of Mercury traversed the planet's magnetotail from 1.25 to 3.25 RM downstream of the planet, where RM is Mercury's radius (2440 km). The encounters took place under northward, southward, and variable‐polarity interplanetary magnetic field (IMF), respectively. The magnetic field strength B in Mercury's magnetotail follows a power law decrease with increasing antisunward distance ∣X∣, B ∼ ∣X∣G, with G varying from −5.4 for northward to −1.6 for southward IMF. Low‐latitude boundary layers (LLBLs) containing strong northward magnetic field were detected at the tail flanks during two of the flybys. The observed thickness of the LLBL was ∼33% and 16% of the radius of the tail during M1 and M3, respectively, but the boundary layer was completely absent during M2. Clear signatures of tail reconnection are evident in the M2 and M3 magnetic field measurements. Plasmoids and traveling compression regions were observed during M2 and M3 with typical durations of ∼1–3 s, suggesting diameters of ∼500–1500 km. Overall, the response of Mercury's magnetotail to the steady southward IMF during M2 appeared very similar to steady magnetospheric convection events at Earth, which are believed to be driven by quasi‐continuous reconnection. In contrast, the M3 measurements are dominated by tail loading and unloading events that resemble the large‐scale magnetic field reconfigurations observed during magnetospheric substorms at Earth.
Data-driven information retrieval in heterogeneous collections of transcriptomics data links SIM2s to malignant pleural mesothelioma
Authors: Caldas José , Gehlenborg Nils , Kettunen Eeva , Faisal Ali , Rönty Mikko , Nicholson Andrew G. , Knuutila Sakari , Brazma Alvis , Kaski Samuel 
Published: November 2011

Abstract
Motivation: Genome-wide measurement of transcript levels is an ubiquitous tool in biomedical research. As experimental data continues to be deposited in public databases, it is becoming important to develop search engines that enable the retrieval of relevant studies given a query study. While retrieval systems based on meta-data already exist, data-driven approaches that retrieve studies based on similarities in the expression data itself have a greater potential of uncovering novel biological insights.
Results: We propose an information retrieval method based on differential expression. Our method deals with arbitrary experimental designs and performs competitively with alternative approaches, while making the search results interpretable in terms of differential expression patterns. We show that our model yields meaningful connections between biological conditions from different studies. Finally, we validate a previously unknown connection between malignant pleural mesothelioma and SIM2s suggested by our method, via real-time polymerase chain reaction in an independent set of mesothelioma samples.
Availability: Supplementary data and source code are available from http://www.ebi.ac.uk/fg/research/rex.
Contact: samuel.kaski@aalto.fi
Supplementary Information: Supplementary data are available at Bioinformatics online.
Nitric Oxide and ProteinS-Nitrosylation Are Integral to Hydrogen Peroxide-Induced Leaf Cell Death in Rice
Authors: Lin Aihong , Wang Yiqin , Tang Jiuyou , Xue Peng , Li Chunlai , Liu Linchuan , Hu Bin , Yang Fuquan , Loake Gary J. , Chu Chengcai 
Published: November 2011

AbstractNitric oxide (NO) is a key redox-active, small molecule involved in various aspects of plant growth and development. Here, we report the identification of an NO accumulation mutant, nitric oxide excess1 (noe1), in rice (Oryza sativa), the isolation of the corresponding gene, and the analysis of its role in NO-mediated leaf cell death. Map-based cloning revealed that NOE1 encoded a rice catalase, OsCATC. Furthermore, noe1 resulted in an increase of hydrogen peroxide (H2O2) in the leaves, which consequently promoted NO production via the activation of nitrate reductase. The removal of excess NO reduced cell death in both leaves and suspension cultures derived from noe1 plants, implicating NO as an important endogenous mediator of H2O2-induced leaf cell death. Reduction of intracellular S-nitrosothiol (SNO) levels, generated by overexpression of rice S-nitrosoglutathione reductase gene (GSNOR1), which regulates global levels of protein S-nitrosylation, alleviated leaf cell death in noe1 plants. Thus, S-nitrosylation was also involved in light-dependent leaf cell death in noe1. Utilizing the biotin-switch assay, nanoliquid chromatography, and tandem mass spectrometry, S-nitrosylated proteins were identified in both wild-type and noe1 plants. NO targets identified only in noe1 plants included glyceraldehyde 3-phosphate dehydrogenase and thioredoxin, which have been reported to be involved in S-nitrosylation-regulated cell death in animals. Collectively, our data suggest that both NO and SNOs are important mediators in the process of H2O2-induced leaf cell death in rice.
Coexistent findings of renal glomerular disease with Hashimoto’s thyroiditis
Authors: Koçak Gülay , Huddam Bülent , Azak Alper , Ortabozkoyun Levent , Duranay Murat 
Published: November 2011

SummaryAim and Background  Hashimoto’s thyroiditis (HT) is a common autoimmune thyroid disease with a female preponderance. Renal involvement in HT is not uncommon. In the present study, we aimed to define the frequency and characteristics of the glomerular diseases associated with HT and further the understanding of any common pathogenesis between HT and glomerular disease.Materials and Methods  We reviewed retrospectively 28 patients with HT who were referred to our Department because of unexplained haematuria, proteinuria or renal impairment from 2007 to 2011. Routine laboratory investigations including blood count, serum biochemistry, urinalysis and 24‐h urinary protein excretion were performed on all patients. Renal biopsy was performed in 20 patients with HT, and the specimens were examined by light microscopy and immunofluorescence staining.Results  We detected four cases of focal segmental glomerulosclerosis (FSGS), four membranous glomerulonephritis (MGN), two minimal‐change disease (MCD), three immunoglobulin A nephritis (IgAN), three chronic glomerulonephritis (CGN) and one amyloidosis. In three patients, the renal biopsy findings were nonspecific. Daily urinary protein excretion and glomerular filtration rates were found to be independent of the level of thyroid hormone and thyroid‐specific autoantibodies.Conclusion  Glomerular pathologies associated with HT are similar to those in the general population, the most common lesions being MGN, FSGS and IgA nephritis.
Global warming threatens the persistence of Mediterranean brown trout
Authors: Almodóvar Ana , Nicola Graciela G. , Ayllón Daniel , Elvira Benigno 
Published: November 2011

AbstractCurrent climate change exacerbates the environmental restrictions on temperate species inhabiting low latitude edges of their geographical ranges. We examined how temperature variations due to current and future climate change are likely to affect populations’ persistence of stream‐dwelling brown trout Salmo trutta at the vulnerable southern periphery of its range. Analysis of 33 years of air temperature data (1975–2007) by time‐series models indicated a significant upward trend and a pronounced shift in air temperature around 1986‐1987. This warming is associated with an ongoing population decline of brown trout, most likely caused by a loss of suitable thermal habitat in lower latitudes since the 1980s. Population decrease may not be attributed to physical habitat modification or angler pressure, as carrying capacity remained stable and populations were not overexploited. We developed regional temperature models, which predicted that unsuitable thermal habitat for brown trout increased by 93% when comparing climate conditions between 1975–1986 and 1993–2004. Predictions from climate envelope models showed that current climate change may be rendering unsuitable 12% of suitable thermal habitat each decade, resulting in an overall population decrease in the lower reaches of around 6% per year. Furthermore, brown trout catches markedly decreased 20% per year. Projections of thermal habitat loss under the ecologically friendly B2 SRES scenario showed that brown trout may lose half of their current suitable habitat within the study area by 2040 and become almost extinct by 2100. In parallel to the upstream movement of brown trout thermal habitat, warm water species are increasing their relative abundance in salmonid waters. Empirical evidence was provided of how current climate change threatens some of the most healthy native brown trout populations in Southern Europe and how forthcoming climate change is expected to further decrease the conservation status of the species.
Impact of precipitation dynamics on net ecosystem productivity
Authors: Parton William , Morgan Jack , Smith David , Del Grosso Stephen , Prihodko Lara , LeCain Dan , Kelly Robin , Lutz Susan 
Published: November 2011

AbstractNet ecosystem productivity (NEP) was measured on shortgrass steppe (SGS) vegetation at the USDA Central Plains Experimental Range in northeastern Colorado from 2001 to 2003. Large year‐to‐year differences were observed in annual NEP, with >95% of the net carbon uptake occurring during May and June. Low precipitation during the 2002 April to June time period greatly reduced annual net carbon uptake. Large precipitation events (>10 mm day−1) promoted carbon uptake, while small precipitation events (<10 mm day−1) enhanced heterotrophic respiration and resulted in a net loss of carbon from the system. Large precipitation event enhanced carbon uptake was attributed to increased soil water content (SWC), which promotes plant photosynthesis. The large precipitation events which occurred from July to October have lower increases in daytime net CO2 uptake (NEPd) due to the presence of low live plant biomass compared to earlier in the growing season. Live aboveground plant biomass (AGB), solar radiation, and SWC were the major variables that controlled NEPd, while AGB, SWC, and relative humidity control nighttime respiration losses (NEPn). Aboveground plant biomass is the most important variable for controlling both NEPd and NEPn dynamics. These results suggest that the major factor controlling growing season NEPn is the amount of carbon fixed via photosynthesis during the day. Heterotrophic soil respiration is greatly enhanced for one to 2 days following rainfall events with daily rainfall events >5 mm having a similar increase in respiration (>3.00 g m Cm−2 day−1). In addition, the size of the heterotrophic respiration pulse is independent of both the amount of time since the last rainfall event and the time of occurrence during the growing season.
Production of heterologous IgG antibody against Heymann nephritis antigen by injections of immune complexes
Authors: Barabas Arpad Z. , Cole Chad D. , Sensen Maria , Lafreniere Rene 
Published: November 2011

SummaryHeterologous IgG antibody (ab) can be produced against Heymann nephritis (HN) antigen (ag) in rabbits by administering it in Freund’s complete adjuvant. The developing abs reacted at high titre with rat kidney brush border (BB) regions of the renal proximal tubules in an indirect fluorescence ab test. A single IV injection of the heterologous ab into a susceptible strain of rat resulted in the localization of IgG ab to glomerular fixed ags, producing immune complex glomerular nephritis. The injected ab also reacted with the BB region of the renal proximal tubules. The aim of this experiment was to find out whether heterologous IgG ab against the HN ag can also be produced in recipient rabbits by injecting immune complexes (ICs) composed of a rat kidney tubular preparation [rat kidney fraction 3 (rKF3)] and donor rabbit–derived rabbit anti‐rKF3 IgG ab. We found that anti‐rKF3 IgG ab – against the BB region of the renal proximal tubules – could be induced in rabbits injected with ICs, and the resulting ab was able to initiate passive HN in rats. This was the first time a pathogenic IgG ab was produced against HN ag in rabbits without the use of adjuvant. Ab responses in recipient rabbits were achieved by ab information transfer. Recipient rabbits injected with the IC produced the same class of immunoglobulin with the same specificity against the target ag rKF3, as was present in the innoculum, namely rabbit anti‐rKF3 IgG ab.
Evidence for genetic differentiation and variable recombination rates among Dutch populations of the opportunistic human pathogen Aspergillus fumigatus
Authors: KLAASSEN CORNÉ H. W. , GIBBONS JOHN G. , FEDOROVA NATALIE D. , MEIS JACQUES F. , ROKAS ANTONIS 
Published: November 2011

AbstractAs the frequency of antifungal drug resistance continues to increase, understanding the genetic structure of fungal populations, where resistant isolates have emerged and spread, is of major importance. Aspergillus fumigatus is an ubiquitously distributed fungus and the primary causative agent of invasive aspergillosis (IA), a potentially lethal infection in immunocompromised individuals. In the last few years, an increasing number of A. fumigatus isolates has evolved resistance to triazoles, the primary drugs for treating IA infections. In most isolates, this multiple‐triazole‐resistance (MTR) phenotype is caused by mutations in the cyp51A gene, which encodes the protein targeted by the triazoles. We investigated the genetic differentiation and reproductive mode of A. fumigatus in the Netherlands, the country where the MTR phenotype probably originated, to determine their role in facilitating the emergence and distribution of resistance genotypes. Using 20 genome‐wide neutral markers, we genotyped 255 Dutch isolates including 25 isolates with the MTR phenotype. In contrast to previous reports, our results show that Dutch A. fumigatus genotypes are genetically differentiated into five distinct populations. Four of the five populations show significant linkage disequilibrium, indicative of an asexual reproductive mode, whereas the fifth population is in linkage equilibrium, indicative of a sexual reproductive mode. Notably, the observed genetic differentiation among Dutch isolates does not correlate with geography, although all isolates with the MTR phenotype nest within a single, predominantly asexual, population. These results suggest that both reproductive mode and genetic differentiation contribute to the structure of Dutch A. fumigatus populations and are probably shaping the evolutionary dynamics of drug resistance in this potentially deadly pathogen.
Accreditation of midwife lactation consultants to perform infant tongue‐tie release
Authors: Amir Lisa H , James Jennifer P , Kelso Georgie , Moorhead Anita M 
Published: November 2011

Amir LH, James JP, Kelso G, Moorhead AM. International Journal of Nursing Practice 2011; 17: 541–547Accreditation of midwife lactation consultants to perform infant tongue‐tie releaseInfants with a tongue‐tie or ankyloglossia have a short lingual frenulum, which can lead to problems with breastfeeding: attachment difficulties, nipple pain and damage, poor weight gain and eventually a reduction in milk supply. Trained clinicians can release the frenulum (frenotomy) in infants having difficulty with breastfeeding. Although traditionally performed by medical practitioners, we argue that this simple procedure is within the scope of practice of other clinicians. This paper outlines the process of setting up and maintaining credentialing for midwife lactation consultants (International Board Certified Lactation Consultants (IBCLCs)) to assess infant tongue‐ties and perform frenotomy when appropriate at a tertiary maternity hospital. Since 2005, 11 midwives/IBCLCs have been credentialed to perform frenotomies at The Breastfeeding Education and Support Services at The Royal Women's Hospital in Melbourne, Australia. We believe that nurses/midwives/lactation consultants working in other settings could be trained to perform frenotomies, thus enabling faster resolution of breastfeeding problems.
Self‐efficacy associated with self‐management behaviours and health status of South Koreans with chronic diseases
Authors: Yoo Hyera , Kim Chun Ja , Jang Yeonsoo , You Mi‐Ae 
Published: November 2011

Yoo H, Kim CJ, Jang Y, You M‐A. International Journal of Nursing Practice 2011; 17: 599–606Self‐efficacy associated with self‐management behaviours and health status of South Koreans with chronic diseasesAlthough prior research in Western societies has revealed an association between self‐efficacy and both self‐management behaviours and better health status, little is known about the applicability of this association in Korean populations. We examined the differences in self‐management behaviours and health status among three groups according to the level of self‐efficacy (high, moderate and low). We used a descriptive and correlational design, and administrated a questionnaire to 322 Korean patients with diabetes mellitus, hypertension or arthritis at three ambulatory clinics in a university medical centre. We performed the Pearson chi‐square test to test for differences in proportions, and the Kruskall–Wallis and Mann–Whitney U‐tests for non‐parametric measures. The level of self‐efficacy was associated with self‐management behaviours (P < 0.05) and with better health status indices (P < 0.001) except fatigue (P < 0.277). The mean age (Mean ± standard deviation, 53.71 ± 12.60), the percentage of high level of education (62.4%) and the level of employment (51.4%) were significantly higher in high self‐efficacy group than in low self‐efficacy group or moderate self‐efficacy group. Further study of the potential factors affecting any relationship between self‐efficacy and fatigue is recommended. Self‐efficacy‐enhancing interventions can be beneficial for Korean chronic patients to improve their self‐management behaviours and health status.
Hemodynamic and oxygenation changes in surgical intensive care unit patients with fever and fever lowering nursing interventions
Authors: Çelik Sevim , Yıldırım İsmail , Arslan İbrahim , Yıldırım Sinan , Erdal Fatih , Yandı Yunus Emre 
Published: November 2011

Çelik S, Yıldırım İ, Arslan İ, Yıldırım S, Erdal F, Yandı YE. International Journal of Nursing Practice 2011; 17: 556–561Hemodynamic and oxygenation changes in surgical intensive care unit patients with fever and fever lowering nursing interventionsThe purpose of this study was to determine the effects of fever and nursing interventions to lower fever on hemodynamic values and oxygenation in febrile (temperature greater than 38.3°C) surgical intensive care unit patients. This retrospective study was conducted in 53 febrile patients out of 519 patients admitted to the surgical intensive care unit at a university hospital. Data were obtained from the medical records, laboratory files and nursing notes. Statistical analysis of the data was analyzed by repeated measures analysis of variance and a paired sample t‐test. The average hourly urine output (F = 5.46; P = 0.002) and systolic blood pressure (F = 2.87; P = 0.03) were significantly lower after fever onset. Heart rate, respiratory rate, positive end‐expiratory pressure settings and FiO2 settings were unchanged after the development of fever. Diastolic blood pressure and oxygen saturation had non‐statistically significant decreases. Nursing interventions for febrile patients consisted of medication administration (69.8%), ice (62.3%) and sponging with tepid water (62.3%). The present results showed that fever was associated with an increase in heart rate, decreased systolic arterial pressure, mean arterial pressure, oxygen saturation and hourly urine output.
Assessment of quality of life and activities of daily living in Turkish patients with heart failure
Authors: Demir Melike , Unsar Serap 
Published: November 2011

Demir M, Unsar S. International Journal of Nursing Practice 2011; 17: 607–614Assessment of quality of life and activities of daily living in Turkish patients with heart failureHeart failure is an entire clinical syndrome affecting many aspects of life, rather than merely a usual disease. This cross‐sectional study was designed to assess heart failure patients' quality of life and activities of daily living (ADL). Seventy‐five patients who applied to the cardiology department were included in the study. The data were obtained using the left ventricular dysfunction scale (LVD‐36) and ADL scale. A statistically significant relationship was found between LVD‐36 and ADL scores and New York Heart Association (NYHA) functional class, previous hospitalization, daily medication, age and education (P < 0.05). It was found that LVD‐36 and ADL scores increase as the level of education increases and as the NYHA functional class, previous hospitalization, number of drugs taken daily and age decrease. The study found a statistically significantly negative relationship between quality of life and ADL (P < 0.05). In patients with heart failure, age, NYHA functional class, number of drugs taken daily independently affected the ADL scores. Additionally, in these patients, education, NYHA functional class, number of drugs taken daily and previous hospitalizations independently affected the quality of life. As the functional situation deteriorates and becomes severe, individual care, training, social support and consultation services for the patient and their family should be increased.