bluuebunny/crossref_metadata_2025_split huggingface dataset:
Disparities and Biases in Food Insecurity Screening Among Admitted Children
Authors: Orr Mary M. , Molina Adolfo L. , Smola Cassandra N. , Hanna Samantha L. , Carpenter Ariel E. , Wu Chang L. 
Published: June 2024

BACKGROUND AND OBJECTIVES
Food insecurity (FI) has increasingly become a focus for hospitalized patients. The best methods for screening practices, particularly in hospitalized children, are unknown. The purpose of the study was to evaluate results of an electronic medical record (EMR) embedded, brief screening tool for FI among inpatients.

METHODS
This was a cross-sectional study from August 2020 to September 2022 for all children admitted to a quaternary children’s hospital. Primary outcomes were proportion of those screened for FI and those identified to have a positive screen. FI was evaluated by The Hunger Vital Sign, a validated 2-question screen verbally obtained in the nursing intake form in the EMR. Covariates include demographic variables of age, sex, race, ethnicity, primary language, and insurance. Statistical analyses including all univariate outcome and bivariate comparisons were performed with SAS 9.4.

RESULTS
There were 31 553 patient encounters with 81.7% screened for FI. Patients had a median age of 6.3 years, were mostly male (54.2%), White (60.6%), non-Hispanic (92.7%), English-speaking (94.3%), and had government insurance (79.8%). Younger (0–2 years), non-White, and noninsured patients were all screened significantly less often for FI (all P &lt; .001). A total of 3.4% were identified as having FI. Patients who were older, non-White, Hispanic, non-English speaking, and had nonprivate insurance had higher FI (all P &lt; .001).

CONCLUSIONS
Despite the use of an EMR screening tool intended to be universal, we found variation in how we screen for FI. At times, we missed those who would benefit the most from intervention, and thus it may be subject to implementation bias.
Establishment and validation of an innovative UPLC-MS/MS approach for quantitation and pharmacokinetics of veliparib in rat plasma
Authors: Xia Mengming , Ma Shunjun , Wang Wanhang , Chen Dizhong , Chen Mengchun , Wen Congcong , Wang Xianqin 
Published: June 2024

AbstractIn this investigation, a rapid and reliable ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) technique was developed for quantification of veliparib in rat plasma and used the method to study the pharmacokinetics and bioavailability of veliparib in rats after oral (6 mg kg−1) and intravenous (2 mg kg−1) administration. Plasma samples were protein precipitated with acetonitrile using midazolam as internal standard. A UPLC HSS T3 chromatographic column was utilized for separation, with a mobile phase consisting of methanol-water-formic acid in gradient elution procedure. Quantitative analysis was performed using multiple reaction monitoring in electrospray positive-ion mode. Veliparib exhibited excellent linearity within the 1–1,000 ng mL−1 range (r > 0.99). The intra- and inter-day precision of veliparib were both within 15%, and the accuracy ranged from 93.7 to 107.7%. The average recovery was above 86%, and the matrix effect was 89.0–95.8%. The AUC(0-t) values for oral and intravenous administration were 1014.7 ± 42.9 and 647.2 ± 85.2 h ng mL−1, respectively, resulting in a bioavailability of 52.3%. The UPLC-MS/MS method established in this study featured a low sample injection volume, a low quantification limit, a short chromatographic runtime, high sensitivity, and selectivity. The developed method can be used for the pharmacokinetic analysis of veliparib in both preclinical and clinical studies.
Educação Popular e processos de emancipação
Authors: Batista Ândrea Francine , Fagundes Maurício César Vitória 
Published: June 2024

O presente artigo tem por objetivo analisar aspectos que possam contribuir para um inventário das experiências de Educação Popular a partir das premissas e pensamento de Paulo Freire, desde o processo de redemocratização até a atualidade. Longe de ser uma sistematização profunda sobre toda essa trajetória, essas linhas buscam a partir de uma pesquisa de natureza qualitativa e bibliográfica, recuperar seus fundamentos, suas principais experiências e sua articulação com as lutas populares deste tempo.

Referências
COUTINHO, Carlos Nelson. Democracia como valor Universal. In: SILVEIRA, Ênio; et all. Encontros com a Civilização Brasileira. RJ: Civilização Brasileira, 1979.
FERNANDES, Florestan. A Revolução Burguesa no Brasil. Ensaios de Interpretação Sociológica. 2ª. Ed. Zahar Editores: RJ, 1976.
FREIRE, Paulo. Conscientização. Teoria e Prática da Libertação. Uma introdução ao pensamento de Paulo Freire. SP: Cortez & Moraes, 1979.
FREIRE, Paulo. Educação como prática da Liberdade. RJ: Paz e Terra, 1967.
FREIRE, Paulo. Educadores de Rua. Uma abordagem crítica. Alternativas ao atendimento aos meninos de rua. N.1. Bogotá, Colômbia: UNICEF, Editorial Gente Nueva, 1989.
FREIRE, Paulo. Extensão ou Comunicação. Coleção O Mundo Hoje. Vol. 24. 8ª. Ed. RJ: Paz e Terra, 1985.
FREIRE, Paulo. Os Cristãos e a Libertação dos Oprimidos. Lisboa, Portugal: Edições Base, 1978.
FREIRE, Paulo. Pedagogia da Autonomia. Saberes necessários à prática educativa. Coleção Leitura. 30ª. Ed. RJ: Paz e Terra, 1996.
FREIRE, Paulo. Pedagogia do Oprimido. 17 ed. RJ: Paz e Terra, 1987.
GRAMSCI, Antônio. Concepção Dialética da História. 3ª. Ed. RJ: Editora Civilização Brasileira, 1978.
JARA, Oscar. A educação popular Latino-americana: história e fundamentos éticos, políticos e pedagógicos. São Paulo: Ação Educativa: CEAAL; ENFOC, 2020.
MÉSZÁROS, István. A crise estrutural do sistema do capital. In Para além do Capital: rumo a uma teoria da transição. Tradução Paulo Cesar Castanheira, Sergio Lessa. SP: Boitempo, 2011.
SOUZA, Ana Inês (Org.) Paulo Freire: vida e obra. 2 ed. São Paulo: Expressão Popular, 2010.
Extensão Rural: perspectivas de Paulo Freire
Authors: Torres-Rego Thelmely 
Published: June 2024

Este texto relaciona aspectos da perspectiva educacional de Paulo Freire incorporados ao trabalho do agrônomo-educador. Estabelecemos essa relação com as práticas de organizações não governamentais vinculadas à Articulação Nacional de Agroecologia. A base de nossa reflexão é a obra Extensão ou comunicação? em que Freire analisa o problema da comunicação entre o camponês e o profissional da extensão rural, compreendendo que este último pode estabelecer a mesma relação presente na educação bancária, devendo sua atuação, que é de caráter educativo, se dar na perspectiva da comunicação.

Referências

BARRINHA, Roselaine Navarro. A agricultura para o capital: uma perspectiva histórica da relação Estado-Capital e teoria do desenvolvimento agrícola. In: NUNES, Sidemar P. (org.). Agroecologia: uma abordagem crítica. Ijuí: Editora Unijuí, 2014.
BRASIL. Lei nº 12.188, de 11 de janeiro de 2010. Institui a Política Nacional de Assistência Técnica e Extensão Rural para a Agricultura Familiar e Reforma Agrária - PNATER e o Programa Nacional de Assistência Técnica e Extensão Rural na Agricultura Familiar e na Reforma Agrária - PRONATER. Diário Oficial da União: seção 1, Brasília, DF, ano 147, n. 7, p. 1-2, 12 jan. 2010.
CAMPOLIN, Aldalgiza Inês; FEIDEN, Alberto. Metodologias participativas em agroecologia. Corumbá: EMBRAPA Pantanal, 2011.
EHLERS, Eduardo. Agricultura sustentável: origens e perspectivas de um novo paradigma. 2. ed. Guaíba: Agropecuária, 1999.
FREIRE, Paulo. Pedagogia do Oprimido. 17 ed. Rio de Janeiro: Paz e Terra, 1987.
FREIRE, Paulo. Extensão ou comunicação? 7. ed. Rio de Janeiro: Paz e Terra, 1983.
FREIRE, Paulo. Cartas à Guiné-Bissau: registros de uma experiência em processo. 2. ed. Rio de Janeiro: Paz e Terra, 1978.
GRAZIANO DA SILVA, José. A modernização dolorosa: estrutura agrária, fronteira agrícola e trabalhadores rurais no Brasil. Rio de Janeiro: Zahar, 1982.
IPEA. Texto para discussão. Agricultura familiar, assistência técnica e extensão rural e a política nacional de ATER. Brasília: Rio de Janeiro: Ipea, 2017.
MOÇAMBIQUE. Diagnóstico (Participativo) Rápido Rural: Manual de Técnicas. Comissão Nacional do Meio Ambiente, s/d.
PETERSEN, Paulo. Participação e desenvolvimento agrícola participativo: uma visão estratégica com ênfase na etapa do diagnóstico. In: PETERSEN, P.; ROMANO, J. O. (Orgs.). Abordagens participativas para o desenvolvimento local. Rio de Janeiro: AS-PTA, 1999.
TORRES-REGO, Thelmely. Formação em agroecologia: Programa do Contestado da AS-PTA. 2016. Tese (Doutorado em Educação) – Centro de Ciências da Educação, Universidade Federal de Santa Catarina, Florianópolis, 2016. Disponível em: https://repositorio.ufsc.br/bitstream/handle/123456789/172586/343442.pdf?sequence=1&isAllowed=y.
VERDEJO, Miguel Expósito. Diagnóstico Rural Participativo: A caixa de ferramenta. Secretaria da Agricultura Familiar. MDA. 2006.
PELATIHAN PEMBUATAN SABUN BATANG AMPAS KOPI BAGI WARGA SEKOLAH DI LINGKUNGAN MGMP KIMIA JAKARTA TIMUR 2
Authors: Suryani Elma 
Published: June 2024

Kegiatan Pelatihan Pembuatan Sabun Batang Ampas Kopi yang dilakukan bertujuan untuk meningkatkan kompetensi para guru dalam menjalankan profesinya sehingga berdampak baik pada kegiatan pembelajaran di sekolah. Disamping itu guru-guru diharapkan juga mampu untuk mengembangkan keterampilannya dibidang sains yang nantinya dapat diterapkan dalam pembelajaran di kelas. Ampas kopi memiliki kandungan-kandungan yang baik untuk kulit seperti zat antioksidan yang cukup tinggi diantaranya flavonoid dan polifenol. Pengetahuan mengenai cara pembuatan sabun batang ampas kopi, sangat bisa mendatangkan keuntungan baik dari segi peluang usaha maupun menjaga kesehatan dan kebersihan diri. Oleh karena itu, perlu dilakukan pelatihan pembuatan sabun batang dengan memanfaatkan ampas kopi. Pelatihan ini diikuti oleh 44 orang guru kimia yang tergabung dalam MGMP Kimia Jakarta Timur 2 dan terdiri dari beberapa kegiatan, yaitu edukasi terkait fungsi dari bahan-bahan yang digunakan dalam pembuatan sabun serta kategori kualitas sabun yang baik, praktek pembuatan sabun dengan metode cold process, diskusi interaktif tentang proses pembuatan sabun beserta cara penerapan praktikum di sekolah, dan diakhiri dengan pengisisan lembar evaluasi oleh peserta. Berdasarkan hasil lembar evaluasi, sebanyak 92,61% merasa puas dengan penyampaian materi, 94,32% menyatakan memperoleh wawasan dan pengetahuan baru, 86,93% menyatakan materi yang disajikan dapat diterapkan dalam pembelajaran kimia di sekolah, dan 88,07% menyatakan materi yang diajarkan memunculkan ide baru untuk melaksanakan pembelajaran interaktif di kelas. Peserta juga berharap pengabdian ini dapat dilaksanakan setiap tahunnya bahkan rata-rata menyatakan 5 kali dalam setahun.
Improving 4D Seismic History Matching Through Data Analysis: A Localized Sensitivity Analysis Workflow
Authors: Kolajoobi Rasool A. , MacBeth Colin , Landa Jorge 
Published: June 2024

Summary
4D seismic history matching (4D SHM) uses 4D seismic data to calibrate reservoir models to reduce production forecast uncertainty and improve reservoir surveillance. 4D seismic becomes very valuable in field developments with sparse well configurations and high areal uncertainty, such as offshore and carbon sequestration projects. Unlike the production data, the conventional uncertainty and sensitivity analysis (SA) with 4D seismic data might return misleading results. Due to the smooth nature of 4D seismic data, it is highly likely that low-frequency signals dampen the impact of model parameters on high-frequency signals. Consequently, some significant parameters are wrongly excluded from the 4D SHM process. Our work aims to address this issue by localizing the SA of 4D seismic data. The idea is first to identify specific seismic signals on the seismic maps and then perform the SA only at the individual locations rather than the entire map. This way we overcome the dampening effects of low-frequency signals.
Several approaches to localize the SA are utilized. In one approach, we defined sliding windows to scan the seismic maps and then executed an SA inside the windows at each location. Other localization approaches employ dimensionality reduction and feature extraction tools. We used principal component analysis (PCA) and advanced machine learning methods such as autoencoders (AEs) and variational autoencoders (VAEs) to transform the 4D seismic maps into a latent space. The information content (the 4D seismic signals) in the high-dimensionality 4D seismic maps is represented by a few features in the latent space. Implementing an SA for each feature in the latent space is equivalent to performing SA with the seismic signals in the original map.
The localized SA scheme is coupled with the ensemble smoother with multiple data assimilation (ESMDA) algorithm to carry out 4D SHM. Three 4D SHM scenarios were defined as full parameterization with no SA, conventional SA using the entire map, and localized SA. We ran these scenarios for a complex synthetic reservoir model based on a real field in the North Sea to match 4D P-wave seismic impedance. The results confirmed the superiority of the localized SA scenario which returned the final ensemble with the lowest error and the best match among the three scenarios. It also turned out that the PCA, for this specific case, is the most suitable methodology to localize the SA.
Emerging Multi-omic Approaches to the Molecular Diagnosis of Mitochondrial Disease and Available Strategies for Treatment and Prevention
Authors: Khaghani Faeze , Hemmati Mahboobeh , Ebrahimi Masoumeh , Salmaninejad Arash 
Published: June 2024

:
Mitochondria are semi-autonomous organelles present in several copies within most
cells in the human body that are controlled by the precise collaboration of mitochondrial DNA
(mtDNA) and nuclear DNA (nDNA) encoding mitochondrial proteins. They play important roles
in numerous metabolic pathways, such as the synthesis of adenosine triphosphate (ATP), the predominant
energy substrate of the cell generated through oxidative phosphorylation (OXPHOS), intracellular
calcium homeostasis, metabolite biosynthesis, aging, cell cycles, and so forth. Previous
studies revealed that dysfunction of these multi-functional organelles, which may arise due to mutations
in either the nuclear or mitochondrial genome, leads to a diverse group of clinically and genetically
heterogeneous disorders. These diseases include neurodegenerative and metabolic disorders
as well as cardiac and skeletal myopathies in both adults and newborns. The plethora of
phenotypes and defects displayed leads to challenges in the diagnosis and treatment of mitochondrial
diseases. In this regard, the related literature proposed several diagnostic options, such as
high throughput mitochondrial genomics and omics technologies, as well as numerous therapeutic
options, such as pharmacological approaches, manipulating the mitochondrial genome, increasing
the mitochondria content of the affected cells, and recently mitochondrial diseases transmission
prevention. Therefore, the present article attempted to review the latest advances and challenges in
diagnostic and therapeutic options for mitochondrial diseases.
Design, Optimization, and Evaluation of Chitosan-2-mercaptobenzoic Acid
as a Dual-functionalized Thiomer
Authors: Marwaha Tejinder K. , Madgulkar Ashwini , Bhalekar Mangesh 
Published: June 2024

Aims:
This study aimed to develop and evaluate mucoadhesive microspheres for the
controlled release of zidovudine using a novel dual-functionalized polymer.

Background:
Mucoadhesive polymers have recently been widely used to prolong the GI residence
time and to modulate the release impact of various mucoadhesive dosage forms. In the
present study, a recently synthesized chitosan derivative, chitosan-2-mercapto benzoic acid, was
used as a mucoadhesive polymer, which was further developed as a dosage form for improving
oral bioavailability of zidovudine drug.

Objective:
The objective of this study is to evaluate the impact of a novel thiolated derivative,
chitosan-2-mercaptobenzoic acid, on the oral bioavailability of the drug zidovudine.

Methods:
The microspheres were prepared using an emulsification crosslinking method with
TPP as the crosslinking agent. Techniques such as FTIR, and DSC were employed to analyze the
microspheres, along with drug content, entrapment efficiency, dissolution studies, mucoadhesion,
ex vivo permeation, and in vivo evaluations.

Results:
Results from FTIR spectroscopy and DSC analysis revealed no interaction between the
drug and polymers. The release kinetics and characterization assessments indicated a zero-order
release profile with anomalous and super case-II transport types. Ex vivo permeation studies on
goat intestinal mucosa demonstrated enhanced mucoadhesive properties and permeability with
the optimized microspheres fabricated using thiomers compared to conventional oral therapy.
Pharmacokinetic investigations showed higher zidovudine plasma levels and Cmax with the administration
of microspheres, particularly those composed of thiomers. The AUC0-24h values for
thiomer microspheres were significantly greater than controls and chitosan microspheres, indicating
improved oral bioavailability potential.

Conclusion:
In conclusion, zidovudine-loaded thiomer-based mucoadhesive microspheres
showed promising results with the ability to enhance the drug's oral bioavailability.
Transforming the Future of Digital Health Education: Redesign of a Graduate Program Using Competency Mapping
Authors: Mun Michelle , Chanchlani Sonia , Lyons Kayley , Gray Kathleen 
Published: June 2024

Abstract
Digital transformation has disrupted many industries but is yet to revolutionize health care. Educational programs must be aligned with the reality that goes beyond developing individuals in their own professions, professionals wishing to make an impact in digital health will need a multidisciplinary understanding of how business models, organizational processes, stakeholder relationships, and workforce dynamics across the health care ecosystem may be disrupted by digital health technology. This paper describes the redesign of an existing postgraduate program, ensuring that core digital health content is relevant, pedagogically sound, and evidence-based, and that the program provides learning and practical application of concepts of the digital transformation of health. Existing subjects were mapped to the American Medical Informatics Association Clinical Informatics Core Competencies, followed by consultation with leadership to further identify gaps or opportunities to revise the course structure. New additions of core and elective subjects were proposed to align with the competencies. Suitable electives were chosen based on stakeholder feedback and a review of subjects in fields relevant to digital transformation of health. The program was revised with a new title, course overview, course intended learning outcomes, reorganizing of core subjects, and approval of new electives, adding to a suite of professional development offerings and forming a structured pathway to further qualification. Programs in digital health must move beyond purely informatics-based competencies toward enabling transformational change. Postgraduate program development in this field is possible within a short time frame with the use of established competency frameworks and expert and student consultation.
Assessment of Sexual Violence Risk Perception in Men Who Have Sex With Men: Proposal for the Development and Validation of “G-Date”
Authors: Angelone D J , Mitchell Damon , Wells Brooke , Korovich Megan , Nicoletti Alexandra , Fife Dustin 
Published: June 2024

Background
Sexual violence (SV) is a significant problem for sexual minorities, including men who have sex with men (MSM). The limited research suggests SV is associated with a host of syndemic conditions. These factors tend to cluster and interact to worsen one another. Unfortunately, while much work has been conducted to examine these factors in heterosexual women, there is a lack of research examining MSM, especially their SV risk perception. Further, MSM are active users of dating and sexual networking (DSN) mobile apps, and this technology has demonstrated usefulness for creating safe spaces for MSM to meet and engage partners. However, mounting data demonstrate that DSN app use is associated with an increased risk for SV, especially given the higher likelihood of using alcohol and other drugs before sex. By contrast, some researchers have demonstrated that DSN technology can be harnessed as a prevention tool for HIV; unfortunately, no such work has progressed regarding SV.

Objective
This study aims to (1) use qualitative and quantitative methods to tailor an existing laboratory paradigm of SV risk perception in women for MSM using a DSN mobile app framework and (2) subject this novel paradigm to a rigorous validation study to confirm its usefulness in predicting SV, with the potential for use in future prevention endeavors.

Methods
To tailor the paradigm for MSM, a team of computer scientists created an initial DSN app (G-Date) and incorporated ongoing feedback about the usability, feasibility, and realism of this tool from a representative sample of MSM. We used focus groups and interviews to assist in the development of G-Date, including by identifying relevant stimuli, developing the cover story, and establishing the appropriate study language. To confirm the paradigm’s usefulness, we are conducting an experimental study with web-based and face-to-face participants to determine the content, concurrent, and predictive validities of G-Date. We will evaluate whether certain correlates of SV informed by syndemics and minority stress theories (eg, history of SV and alcohol and drug use) affect the ability of MSM to detect SV risk within G-Date and how paradigm engagement influences behavior in actual DSN app use contexts.

Results
This study received funding from the National Institute on Alcohol Abuse and Alcoholism on September 10, 2020, and ethics approval on October 19, 2020, and we began app development for aim 1 immediately thereafter. We began data collection for the aim 2 validation study in December 2022. Initial results from the validation study are expected to be available after December 2025.

Conclusions
We hope that G-Date will enhance our understanding of factors associated with SV risk and serve as a useful step in creating prevention programs for this susceptible population.
Advances in Quantitative and Qualitative Assessment of Collagen in Cutaneous Wound Healing
Authors: Santoso Clarissa Nadya , Widyantara K. Ariex , Kencana Nyoman Bayu Wisnu , Setyajati Flavia Domitila Erika , Setiawati Agustina 
Published: June 2024

Wound healing treatment is a challenging strategy in skin drug delivery due to its complexities. During wound healing stages, fibroblast deposit extracellular matrix components, which majority is collagen. Fibrillar collagen, particularly collagen I, is the predominant skin collagen during the healing process. Collagen analysis is a crucial process in wound healing study since it indicates impairment process of collagen production such as scar formation which is aesthetically unwanted. Therefore, recent studies developed quantitative and qualitative evaluation of collagen fiber based on histological staining. Thus, a comprehensive discussion of those studies to provide an insight for pharmacists, dermatologists, and skin researchers to designate a precise assessment in wound healing process.

Keywords: skin, wound, collagen, assessment