bluuebunny/crossref_metadata_2025_split huggingface dataset:
E-Cadherin Expression in Endometrial Carcinoma
Authors: Ullas Geethika P , M Sheela K 
Published: May 2024

Background
In this study, we wanted to determine the proportion of negative E-cadherin expression in endometrial carcinoma cases received in the Department of Pathology and evaluate the E-cadherin expression in different histological subtypes of endometrial carcinoma.
Methods
This was a cross-sectional study conducted over one year in the Department of Pathology, Government Medical College, Thiruvananthapuram, Kerala. 52 specimens histopathologically diagnosed as endometrial carcinoma in the Department of Pathology, were studied. Age, histological subtype, grade, stage and E-cadherin staining were recorded. Data were entered into an Excel sheet and analysed with SPSS.
Result
Clinicopathological features of were studied and the median age group of the patients was between 51-60 years. The majority of cases were of endometrioid type and presented at stage IA (69.2 %). Negative E cadherin expression was seen more commonly in Type II endometrial carcinomas (50 & 33.3 % of serous and clear cell carcinoma respectively). Among the Type I carcinoma, grade 3 tumours showed the most proportion of negative E-cadherin staining pattern (33.3 %).
Conclusion:
The study concluded that most of the tumours occurred in the postmenopausal age group and the majority of cases were in stage IA, most cases were of endometrioid type. E-cadherin was lost most commonly in high-grade endometrioid carcinoma and Type 2 carcinomas. Among the 3 grades of endometrioid carcinoma, grade 3 (33.3 %) had the highest proportion of negative staining and grade 1 had the highest proportion of positive staining characteristics. (57.1 %).
Developing improved machine learning methods to predict the flow characteristics through vertical and horizontal transitions in open channels
Authors: Gad Manal , Abd-Elhamid Hany , Zeleňáková Martina , Marie Hanaa Salem , Nassar Wael O. 
Published: May 2024

ABSTRACT
Transitions in an open channel refer to the change in flow behavior due to changes in the channel geometry. Determining flow characteristics through transitions is an important topic as it is necessary to guarantee the ideal hydraulic performance of water structures with low costs. This research focuses on the flow characteristics through vertical and horizontal transitions through experimental study and then utilizing machine learning to predict the flow characteristics. The proposed framework aims to develop both the cascade-forward artificial neural network (CFANN) model and the regression model to enhance the prediction of flow characteristics. The first model developed modifies the CFANN using dandelion optimizer (DO) to determine the ideal CFANN configuration. The second model used gene expression programming to develop statistical equations. The obtained CFANN–DO model has proven high accuracy in predicting the flow rates at various water loads and speeds achieving a coefficient of determination of approximately 100% for training data and 99.5% for testing data. Finally, predicting the characteristics of vertical and horizontal transitions in open channels is a critical issue. Manipulating these transitions can create a habitat for aquatic organisms, reduce erosion, and improve the overall environment.
Impact of Bioactive Compounds in the Management of Various Inflammatory
Diseases
Authors: Babbar Ritchu , Kaur Arpanpreet , Vanya  , Arora Rashmi , Gupta Jeetendra Kumar , Wal Pranay , Tripathi Arpan Kumar , Koparde Akshada Amit , Goyal Pradeep , Ramniwas Seema , Gulati Monica , Behl Tapan 
Published: May 2024

:
Inflammation is an individual’s physiological response to a sequence of physical, chemical, or infectious
stressors acting mainly to provide localized protection. Although inflammation is a protective and thus
beneficial process, its excess or prolonged action can be harmful to the body. An increasing number of the population
worldwide are changing their lifestyles, which leads to a rise in inflammatory diseases, such as atherosclerosis,
angina pectoris, myocardial infarction, ulcerative colitis, cancer, and many more. Their treatment is
based majorly on the pharmacological approach. However, natural products or bioactive compounds are of
great significance in inflammation therapy because they show minimum side effects and maximum bioavailability.
Therefore, it is critical to investigate bioactive substances that can modify target functions associated
with oxidative stress defense and might be used to achieve various health benefits. This review accentuates the
essence of bioactive chemicals used in the treatment of inflammation and other inflammatory illnesses. These
bioactive compounds can be of any origin, such as plants, animals, bacteria, fungi, marine invertebrates, etc.
Bioactive compounds derived from plant sources, such as glycyrrhizin, lignans, lycopene, resveratrol, indoles,
and phenolic and polyphenolic compounds, work mainly by reducing oxidative stress and thereby preventing
various inflammatory disorders. A large diversity of these anti-inflammatory bioactive compounds has also
been discovered in marine environments, giving rise to an increase in the interest of various scientists in
marine invertebrates and microbes. The vast diversity of microbes found in the marine environment represents
an enormous supply to extract novel compounds, such as from bacteria, cyanobacteria, fungi, algae, microalgae,
tiny invertebrates, etc. In the present review, an attempt has been made to summarize such novel bioactive
compounds that help prevent inflammatory responses via different mechanisms of action.
CRISPR/Cas9 Technology: A Novel Approach to Obesity Research
Authors: Khademi Zahra , Mahmoudi Zahra , Sukhorukov Vasily N. , Jamialahmadi Tannaz , Sahebkar Amirhossein 
Published: May 2024

:
Gene editing technology, particularly Clustered Regularly Interspaced Short Palindromic Repeats
(CRISPR)/CRISPR-associated protein 9 (Cas9) has transformed medical research. As a newly developed
genome editing technique, CRISPR technology has strongly assisted scientists in enriching their comprehension
of the roles of individual genes and their influences on a vast spectrum of human malignancies. Despite
considerable progress in elucidating obesity's molecular pathways, current anti-obesity medications fall short
in effectiveness. A thorough understanding of the genetic foundations underlying various neurobiological pathways
related to obesity, as well as the neuro-molecular mechanisms involved, is crucial for developing effective
obesity treatments. Utilizing CRISPR-based technologies enables precise determination of the roles of
genes that encode transcription factors or enzymes involved in processes, such as lipogenesis, lipolysis, glucose
metabolism, and lipid storage within adipose tissue. This innovative approach allows for the targeted suppression
or activation of genes regulating obesity, potentially leading to effective weight management strategies.
In this review, we have provided a detailed overview of obesity's molecular genetics, the fundamentals of
CRISPR/Cas9 technology, and how this technology contributes to the discovery and therapeutic targeting of
new genes associated with obesity.
A Systematic Review and Meta-analysis of the Relationship between Statin Intake
and Esophageal Cancer
Authors: Khaghani Armin , Kasiri Karamali , Heidari-Soureshjani Saeid , Sherwin Catherine M.T. , Mardani-Nafchi Hossein 
Published: May 2024

Background:
Esophageal cancer is a malignant tumor with a low survival rate. Statins, commonly
prescribed for their lipid-lowering effects, have been suggested to possess potential chemopreventive properties
against various cancers, including esophageal cancer.

Objectives:
This systematic review studied the association between statin intake and esophageal cancer.

Methods:
To conduct this systematic review and meta-analysis, we reviewed studies published between 1980 and
June 2023 in Web of Science (WOS), Embase, MEDLINE/PubMed, Scopus, and Cochrane Library databases
according to the PRISMA guidelines. Data extraction, quality assessment, and statistical analyses were performed
using predefined protocols. We used various statistical tests conducted by Stata statistical software. Statistical
significance was considered significant at p < 0.05.

Results:
Twenty-one studies were collected and analyzed. The meta-analysis demonstrated that the odds ratio
(OR) of esophageal cancer in patients treated with statins was 0.65 (95% CI: 0.57-0.75, p < 0.001) compared to
the non-receiving group. The ORs for case-control and cohort studies were 0.67 (95% CI:0.54-0.83, p < 0.001)
and 0.62 (95% CI:0.55-0.71, p < 0.001), respectively. The investigation into the relationship between the statins
intake and the incidence of esophageal cancer did not reveal any indication of publication bias according to both
Begg's test (p = 0.966) and Egger's test (p = 0.113).

Conclusion:
The results revealed that the odds of esophageal cancer in patients treated with statins decreased by
35% compared to patients not treated with statins. However, further well-designed prospective studies are needed
to validate these findings and understand the underlying mechanisms of statins in preventing esophageal cancer.
AKULTURASI KOMPETENSI BIDANG CHASIS KENDARAAN PADA KURIKULUM BERBASIS KERJASAMA INDUSTRI
Authors: Suhartanta Suhartanta , Efendi Yosep , Wakid Muhkamad , Us Tawardjono 
Published: May 2024

AbstractThe potential for human resource development in Chassis' area of expertise is still very broad. In addition, the time span of its usefulness is still very long because it is not displaced by the transition of electric vehicles. Therefore, it is important to conduct research that develops the competence of the Chassis area of expertise, which then cultures it into the curriculum and learning of automotive workshops and partner industries. This type of research is qualitative descriptive research. Data were collected through surveys, interviews, FGDs and observations in the automotive industry regarding wheel alignment competencies. The results showed that attitudes that can be observed and experienced developments when carrying out jobs in campus workshops and the chassis industry include accuracy in measuring chassis components, dexterity in carrying out the sequence of work and responsibility in working on vehicle maintenance and repair needs. In the aspect of automotive technology knowledge, components that can be observed for development includebasic knowledge, working principles, procedures, understanding of construction, knowledge of vehicle safety and security equipment requirements. Meanwhile, the ability to diagnose tire/wheel problems/damage skills according to manual repair procedures and skills in carrying out vehicle chassis maintenance procedures..
Tracking and Profiling Repeated Users Over Time in Text-Based Counseling: Longitudinal Observational Study With Hierarchical Clustering
Authors: Xu Yucan , Chan Christian Shaunlyn , Chan Evangeline , Chen Junyou , Cheung Florence , Xu Zhongzhi , Liu Joyce , Yip Paul Siu Fai 
Published: May 2024

Background
Due to their accessibility and anonymity, web-based counseling services are expanding at an unprecedented rate. One of the most prominent challenges such services face is repeated users, who represent a small fraction of total users but consume significant resources by continually returning to the system and reiterating the same narrative and issues. A deeper understanding of repeated users and tailoring interventions may help improve service efficiency and effectiveness. Previous studies on repeated users were mainly on telephone counseling, and the classification of repeated users tended to be arbitrary and failed to capture the heterogeneity in this group of users.

Objective
In this study, we aimed to develop a systematic method to profile repeated users and to understand what drives their use of the service. By doing so, we aimed to provide insight and practical implications that can inform the provision of service catering to different types of users and improve service effectiveness.

Methods
We extracted session data from 29,400 users from a free 24/7 web-based counseling service from 2018 to 2021. To systematically investigate the heterogeneity of repeated users, hierarchical clustering was used to classify the users based on 3 indicators of service use behaviors, including the duration of their user journey, use frequency, and intensity. We then compared the psychological profile of the identified subgroups including their suicide risks and primary concerns to gain insights into the factors driving their patterns of service use.

Results
Three clusters of repeated users with clear psychological profiles were detected: episodic, intermittent, and persistent-intensive users. Generally, compared with one-time users, repeated users showed higher suicide risks and more complicated backgrounds, including more severe presenting issues such as suicide or self-harm, bullying, and addictive behaviors. Higher frequency and intensity of service use were also associated with elevated suicide risk levels and a higher proportion of users citing mental disorders as their primary concerns.

Conclusions
This study presents a systematic method of identifying and classifying repeated users in web-based counseling services. The proposed bottom-up clustering method identified 3 subgroups of repeated users with distinct service behaviors and psychological profiles. The findings can facilitate frontline personnel in delivering more efficient interventions and the proposed method can also be meaningful to a wider range of services in improving service provision, resource allocation, and service effectiveness.
Philosophical Meaning of Traditional Wedding Rituals of the Singkil Tribe
Authors: Rizki Annisa , Aslam Nur Aslam Nur , Munawiah  
Published: May 2024

This article aims to describe the philosophical meaning of the traditional weddings of the Singkil Tribe based on data from Lae Butar Village, Gunung Meriah District, Aceh Singkil Regency. This research uses descriptive methods with data collection techniques, namely observation, interviews, and documentation. In the process of presenting data, researchers use data analysis techniques that describe, interpret and validate. The results of the research show that wedding customs are still implemented and maintained by the people in Lae Butar Village to this day. Meanwhile, the traditional wedding procession of the Singkil Tribe in Lae Butar Village is, first, mekhisik, tandek sintua, mebagah, khapat famili, umba-umba and gaba-gaba. The second day, namely, marriage contract, mangan mido tawar, slaughtering animals, religious lectures, hine tetuhu. The third day involve dalalel khairat, tepung tawakh, and hine menangko. On the last day is mangan mekhadat, temetok and pengakhak Mangan mido tawar has a philosophical meaning, which means that those holding a wedding will receive blessings and avoid undesirable things. Tepung tawar means, so that the bride and groom get blessings from the procession. The Singkil Tribe wedding procession in Lae Butar Village combines marriage and custom directly on the same day.
ObRb, AdipoR1, and CYP19 gene expression showsignificant association with obesity and overweight inhealthy women
Authors: López González Jessica Berenice , Sandoval Cabrera Antonio , Laura Sánchez Hernández  , Morales ávila Enrique , Santillán Benítez Jonnathan Guadalupe 
Published: May 2024

Obesity and overweight are diseases characterized by excessive accumulation of adipose tissue in the body and are defined as an increase in Body Mass Index (BMI) with values greater than 25 kg/m2. Multiple causes of these increases in BMI have been reported. Some have been attributed to the expression of several genes involved in the leptin and adiponectin pathway as well as postmenopausal stage in women.
In this research, we focused on evaluating whether the expression of ObRb, AdipoR1, and CYP19 genes have any association with the increase in BMI in the female population of Mexico City over 55 years of age. For this, we worked with a group of 45 women volunteers without the diagnosis of any confirmed pathology. The study population was classified into three groups (average weight, overweight and obese) according to their BMI and was characterized according to their clinical data of blood cytometry and blood chemistry. At the same time, RT-PCR determined ObRb, Adi-poR1, and CYP19 gene expression.
Obtained results showed a moderate correlation (r=0.648, p=0.043) of ObRb gene expression in women with obesity and a moderate negative correlation (r= -0.389, p=0.034) AdipoR1 gene in women with overweight or obesity.
Based on BMI data, more than 70 % of the study population was overweight and obese.Also, it was found that 64 % of the study population exceeded 150 mg/dL of triglycerides which is the normal healthy range.
The role of developing countries in the global fashion industry sustainability discourse: Ghana in perspective - A narrative review
Authors: Amankwah Akosua Mawuse , Appiah Edward , Frimpong Charles , Kent Anthony 
Published: May 2024

Fashion Industry practices globally are considered to have major negative impacts on both the environment and society. Production and consumption have increasingly moved towards the industry’s model of take-create-dispose. As this phenomenon is observed to take center stage in more industrialized and advanced nations, developing countries including Ghana, also contribute directly or indirectly to the negative impacts. Fashion production in Ghana is predominantly centered on small to medium-scale enterprises, and their mode of operation allows for customized small runs tailored to specific end-customers, thereby providing an avenue for exploring sustainable strategies that may have a positive impact on the environment and society. This paper takes a narrative review approach to how the fashion industry in Ghana impacts sustainability and the opportunities to make positive impacts on sustainability at a global level. It demonstrates how Ghana, as a developing country, imports raw materials for both textile and apparel production from counterparts in developing and developed countries and contributes to negative environmental impacts associated with sourcing countries. However, with the emergence of sustainable strategies, local contemporary fashion designers can embrace culturally friendly sustainable models to enhance their practice toward industry sustainability.
Enhancing Export Delivery Performance: Strategic Interventions for Overcoming Late Deliveries in Malaysia’s Food Trading Company
Authors: Soon Chin Pau , Anis Azilah , Muhamad Mira Qerul Barriah 
Published: May 2024

The present study focuses on a prominent food trading company in Malaysia, which boasts a strong market presence and a commitment to quality in diverse Southeast Asian markets. Despite its strong market presence, the food trading company struggles with significant delays in delivering its export items, adversely impacting customer satisfaction and competitive advantage. The identified delivery performance discrepancies in certain Southeast Asian countries highlight a critical area for investigation. Thus, this study aims to identify the underlying causes of these late deliveries and propose strategic solutions to enhance delivery efficiency. Employing a qualitative case study methodology, the investigation involves semi-structured interviews with ten experienced company employees selected through a purposive sampling technique. The analysis followed a rigorous qualitative data analysis procedure, including data reduction, data display, drawing, and verifying conclusions. The findings reveal four primary causes of late delivery: 1) INACCURATE INFORMATION, 2) INEFFICIENT PRODUCTION PROCESS, 3) TRANSPORTATION SCHEDULING, and 4) LIMITATION OF THE SYSTEM. To address the causes, the study recommends INTEGRATING SYSTEM INFORMATION to resolve the issues of INACCURATE INFORMATION and LIMITATION OF THE SYSTEM, alongside RESOURCING ALTERNATIVE SHIPPING AGENTS as a strategic approach to overcome INEFFICIENT PRODUCTION PROCESS and TRANSPORTATION SCHEDULLING. The findings advocate that the top management of the food trading company to embrace system integration and establish partnerships with reliable transportation agencies to address immediate late delivery concerns. Implementing these strategies will not only address issues of late deliveries but also enhance its export delivery performance, ensure customer satisfaction, and maintain its international market leadership.
Failing with Flying Colors: The Saga That Led to a Disclaimer of Opinion on the Department of Defense’s First Full-Scope Audit
Authors: Tribou Kimberly J. , Badua Frank 
Published: May 2024

ABSTRACT
Using primary sources composed of U.S. federal legislation and federal agency audit reports, this paper documents and analyzes events in the nearly two-and-a-half-century-long process leading up to the disclaimer of opinion on the first full-scope audit of the Department of Defense (DOD) consolidated financial statements in 2018. It also applies theoretical lenses from political science, namely governmentality and public accountability, to characterize the development of these events and their ultimate aftermath, including results of subsequent DOD audits up to the most recently completed one (FY 2023). Thus, the paper extends into the present century the historiography of accounting and auditing over military endeavors in the U.S., which stretches back to the period just before the American Civil War, and analyzes its accounting and societal significance, thereby responding to a lacuna in the literature identified in earlier research and contributing to the discussion on accountability and good government.