bluuebunny/crossref_metadata_2025_split huggingface dataset:
Communication about sexuality and intimacy in couples affected by lung cancer and their clinical‐care providers
Authors: Lindau Stacy Tessler , Surawska Hanna , Paice Judith , Baron Shirley R. 
Published: June 2010

AbstractObjective: Little is known about the effects of lung cancer on intimate and sexual relationships. This study explores health‐care provider, patient, and partner perspectives on: (1) the effects of lung cancer on physical and emotional intimacy, (2) the ways in which intimacy affects the experience of living with lung cancer, and (3) communication about intimacy and sexuality in the context of lung cancer.Methods: Qualitative, in‐depth interviews with eight cancer‐care providers and 13 married couples (ages 43–79) affected by lung cancer were conducted and audiotaped in the clinical setting. Interviews were transcribed, iteratively analyzed, and coded according to the above domains. Coding was performed independently by members of an interdisciplinary team; inter‐rater reliability was assessed using the kappa statistic; and analyses were summarized by domain.Results: Most cancer‐care providers and couples affected by lung cancer believed intimacy and sexuality issues were salient, yet few reported discussing these. Couples described negative and positive effects of cancer on intimacy. Negative effects were driven by cancer or its treatment, including physical and psychological effects. Positive effects included an increase in non‐coital physical closeness and appreciation of the spouse. Age was perceived as an important factor influencing the relationship between lung cancer and intimacy.Conclusions: Emotional intimacy and sexuality are important concerns for couples affected by lung cancer. The findings suggest previously unrecognized positive effects of lung cancer on emotional and physical intimacy. Couples affected by lung cancer and providers believe these issues are relevant for lung cancer care. Copyright © 2010 John Wiley & Sons, Ltd.
Many‐body meets QM/MM: Application to indole in water solution
Authors: Conte Adriano Mosca , Ippoliti Emiliano , Del Sole Rodolfo , Carloni Paolo , Pulci Olivia 
Published: June 2010

AbstractAromatic chromophores are used as optical probes to investigate the structure of complex biological systems. For this purpose, it is crucial to understand the role of the bio‐chemical environment in the modification of their optical properties. Here we present a theoretical method to analyze this aspect on large scale systems, like biologically relevant molecules in aqueous solution. We combine many body perturbation theory with a quantum‐mechanics/molecular‐mechanics (QM/MM) approach. We include quasi‐particle and excitonic effects for the calculation of optical absorption spectra in a QM/MM scheme. In agreement with the experiments, we find that the solvent induces a redshift in the main spectral peak of indole, and we demonstrate this shift originates both from electrostatic and geometrical effects.magnified image
Total bremsstrahlung spectra in targets of Al, Ti, Sn and Pb produced by complete absorption of 90Sr β particles
Authors: Singh Tajinder , Kahlon K. S. , Dhaliwal A. S. 
Published: June 2010

AbstractTotal bremsstrahlung (BS) spectra in thick targets of Al, Ti, Sn and Pb produced by complete absorption of 90Sr β particles (0–546 keV) are reported in the photon energy region of 10–30 keV. The experimental BS spectral photon distributions were compared with the theoretical BS spectral photon distributions obtained from Elwert corrected (non‐relativistic) Bethe–Heitler theory, modified Elwert factor (relativistic) Bethe–Heitler theories for ordinary bremsstrahlung (OB) and the modified Elwert factor (relativistic) Bethe–Heitler theory, which include the polarization bremsstrahlung (PB) into OB in stripped atom approximation. It has been observed that the experimental results are showing better agreement with the modified Elwert factor (relativistic) Bethe–Heitler theory having the contribution of PB at photon energy from 10 to 30 keV. This indicates the importance of PB in BS spectra, while studying the spectral photon distributions produced by continuous β particles having energy range of 0–546 keV in thick metallic targets. Further, it is observed that the contribution of PB into OB increases with increase in atomic number of the target and decreases with increase in photon energy. Copyright © 2010 John Wiley & Sons, Ltd.
Determination and transport of phase transformation yield surfaces for shape memory alloys
Authors: Gibeau E. , Laydi M.R. , Lexcellent C. 
Published: June 2010

AbstractOne important feature in the description of the shape memory alloys is the determination of the yield surfaces of phase transformation. They can be presented as surfaces in the phase transformation martensitic strain space. In this paper the transition from this stress to the classical stress space is performed. Two application cases concerning bi‐axial loading (bi‐tension and tension‐torsion) are discussed in details.
Psychiatric and cognitive profile in Anderson‐Fabry patients: a preliminary study
Authors: Segal Perri , Kohn Yoav , Pollak Yehuda , Altarescu Gheona , Galili‐Weisstub Esti , Raas‐Rothschild Annick 
Published: June 2010

AbstractAnderson‐Fabry disease (AFD) is an X‐linked inherited lysosomal storage disorder disease caused by a deficiency in the activity of the α‐galactosidase enzyme. We investigated neuropsychological and psychiatric function in AFD patients. We studied 16 AFD patients, aged 7 to 61 years. Intelligence, language, vision‐spatial abilities, memory, sensorimotor abilities, and attention and executive functions were tested with a computerized test battery as well as standard paper and pencil tests. The results were compared to known age‐based norms. In addition, all patients were screened for lifelong DSM‐IV Axis‐I and Axis‐II psychiatric diagnoses, and 4 were interviewed by a psychiatrist. Performance on most cognitive measures was within average range. All measures of information processing speed were significantly reduced, as were some measures of executive functions. Ten out of 16 patients met DSM‐IV criteria for Axis I or Axis II diagnoses at some point in their lives. This preliminary study delineates a psychiatric and cognitive phenotype in AFD patients and contributes to the growing field of characterizing behavioral phenotypes of patients with genetic diseases. We suggest that psychiatric and neuro‐psychological evaluation be included in the patient's evaluation.
Using animal models of enriched environments to inform research on sensory integration intervention for the rehabilitation of neurodevelopmental disorders
Authors: Reynolds Stacey , Lane Shelly J. , Richards Lorie 
Published: June 2010

Abstract
The field of behavioral neuroscience has been successful in using an animal model of enriched environments for over five decades to measure the rehabilitative and preventative effects of sensory, cognitive and motor stimulation in animal models. Several key principles of enriched environments match those used in sensory integration therapy, a treatment used for children with neurodevelopmental disorders. This paper reviews the paradigm of environmental enrichment, compares animal models of enriched environments to principles of sensory integration treatment, and discusses applications for the rehabilitation of neurodevelopmental disorders. Based on this review, the essential features in the enriched environment paradigm which should be included in sensory integration treatment are multiple sensory experiences, novelty in the environment, and active engagement in challenging cognitive, sensory, and motor tasks. Use of sensory integration treatment may be most applicable for children with anxiety, hypersensitivity, repetitive behaviors or heightened levels of stress. Additionally, individuals with deficits in social behavior, social participation, or impairments in learning and memory may show gains with this type of treatment.
Implementing an In Situ Alkaline Transesterification Method for Canola Biodiesel Quality Screening
Authors: Haagenson Darrin M. , Brudvik Rachel L. , Lin Hongjian , Wiesenborn Dennis P. 
Published: June 2010

AbstractIncreasing demand for canola (Brassica napus) as an edible oil crop and biodiesel (B100) feedstock has encouraged genetic development for increased oil yields and expanded acreage in the US Northern Plains. Crop production environment and plant genetics influence metabolism and fatty acid composition, but the influence of this interaction on the resulting fatty acid methyl esters (FAME) is not clearly understood. The objective of this study was to develop a canola in situ transesterification (TE) method for facilitating the identification of genetic, abiotic or biotic factors impacting B100 quality, and to evaluate FAME quality properties from conventional TE (degummed oil) and in situ TE methods. In situ reactions containing 40 g canola flour conducted for 6 h at 60 °C with a 275:1:1.05 M ratio of methanol:triacylglycerol (TAG):KOH provided 80% conversion of seed lipid to FAME. Replicated reactions provided sufficient FAME volume for measuring several ASTM D6751‐09 standards including cloud point, kinematic viscosity, acid value, moisture content, oxidative stability, and total glycerin, but adjustments are necessary to provide sufficient volumes for routine analysis of cold soak filtration test. The established in situ protocol would permit weekly analysis of 40 samples and the in situ TE method provides an opportunity to evaluate the impact of genetic or environmental factors on B100 quality.
Large‐Scale Screening of Intact Castor Seeds by Viscosity Using Time‐Domain NMR and Chemometrics
Authors: Berman Paula , Nizri Shahar , Parmet Yisrael , Wiesman Zeev 
Published: June 2010

AbstractCastor is one of the most promising non‐edible oil crops, due to its high oil content and since it can be grown on marginal lands and in a semi‐arid climate. However, the high content of ricinoleic acid results in an extremely high viscosity of castor‐based biodiesel. In this study, we report on the development of a rapid and non‐destructive method for large‐scale screening of intact castor seeds according to their viscosity by time domain NMR and chemometrics. A qualitative principal component analysis model was constructed, where each observation was assigned to a different viscosity group. This model straightforwardly detects desirable outliers, and can also be applied for detection of other transgenic oilseeds, especially those containing small levels of hydroxylated fatty acid.
The role of regulatory fit on the attraction effect
Authors: Chatterjee Subimal , Roy Rajat , Malshe Ashwin Vinod 
Published: June 2010

AbstractWe show that adding entrant brands to a choice set compr ising of a predominantly promotion brand and a predominantly prevention brand can make both promotion and prevention‐oriented consumers susceptible to the attraction effect. If an entrant targets the brand possessing superior promotion (prevention) feature, the resulting dominance relationship allows the promotion (prevention) focused consumers to sustain their regulatory focus. Entrant brands (and the associated dominance heuristic) therefore contribute to decision value by allowing both promotion and prevention‐focused consumers pursue their goal in a way that fits with their regulatory concerns.
Targeting leukemic stem cells by breaking their dormancy
Authors: Essers Marieke Alida Gertruda , Trumpp Andreas 
Published: June 2010

AbstractTransient or long‐term quiescence, the latter referred to as dormancy are fundamental features of at least some adult stem cells. The status of dormancy is likely a critical mechanism for the observed resistance of normal HSCs and leukemic stem cells (LSCs) to anti‐proliferative chemotherapy. Recent studies have revealed cytokines such as Interferon‐alpha (IFNα) and G‐CSF as well as arsenic trioxide (As2O3) to be efficient agents for promoting cycling of dormant HSCs and LSCs. Most interestingly, such cell cycle activated stem cells become exquisitely sensitive to killing by different chemotherapeutic agents, suggesting that dormant LSCs in patients may be targeted by a sequential two‐step protocol involving an initial activation by IFNα, G‐CSF or As2O3, followed by targeted chemotherapy.
Pancreatic cancer stem cells – update and future perspectives
Authors: Lonardo Enza , Hermann Patrick C. , Heeschen Christopher 
Published: June 2010

AbstractSolid tumours are the most common cancers and represent a major therapeutic challenge. The cancer stem cell hypothesis is an attractive model to explain the functional heterogeneity commonly observed in solid tumours. It proposes a hierarchical organization of tumours, in which a subpopulation of stem cell‐like cells sustains tumour growth, metastasis, and resistance to therapy. We will present the most recent advances in the cancer stem cell field, with particular emphasis on pancreatic cancer as one of the deadliest human tumours, and highlight open questions and caveats to be addressed in future studies. There is increasing evidence that solid tumours including pancreatic cancer are hierarchically organized and sustained by a distinct subpopulation of cancer stem cells. However, direct evidence for the validity of the cancer stem cell hypothesis in human pancreatic cancer remains controversial due to the limitations of xenograft models but supportive data are now emerging from mouse models using related or different sets of markers for the identification of murine cancer stem cells. Therefore, while the clinical relevance of cancer stem cells remains a fundamental issue for this rapidly emerging field, current findings clearly suggest that specific elimination of these cells is possible and therapeutically relevant. Targeting of signalling pathways that are of particular importance for the maintenance and the elimination of cancer stem cell as the proposed root of the tumour may lead to the development of novel treatment regimens for pancreatic cancer. Here we will review the current literature on pancreatic cancer stem cells and the future perspective of this rapidly emerging field.
Radiofrequency thermal ablation versus ‘cold steel’ for supra-auricular excision of preauricular sinus: comparative study
Authors: Bajwa H , Kumar S 
Published: June 2010

AbstractObjective:To compare the results of radiofrequency thermal ablation versus ‘cold steel’ excision, for supra-auricular excision of preauricular sinus.Study design:Prospective study. Observations included recurrence, intra-operative bleeding, operation time and ease of dissection.Setting:Tertiary referral hospital.Subjects and methods:Sixty cases of preauricular sinus were assigned randomly to two groups (30 cases each). Group one patients underwent cold steel sinus excision, whereas group two patients underwent radiofrequency-assisted sinus excision.Results:Fifty patients were operated upon, with a mean age of 12.26 years. Most patients were aged between zero and five years (40 per cent). The average patient follow-up time was 15 months (range, six to 24 months). Recurrence rates were 23 per cent in group one and 3 per cent in group two; this difference was statistically significant (p = 0.016). Dissection of the sinus tract was reported to be much easier in the radiofrequency group, compared with the cold steel group (p = 0.023), with minimal bleeding.Conclusion:From our observations, radiofrequency-assisted, local, wide excision appears to be preferable for treatment of preauricular sinus, compared with cold steel excision, as it allows better peri-operative visualisation, easier dissection, minimal bleeding and a lower subsequent recurrence rate (3.3 per cent).
Risk factors associated with dizziness during treatment of mucosal leishmaniasis with meglumine antimoniate: 16-year retrospective study of cases from Rio de Janeiro, Brazil
Authors: Araujo-Melo M H , Meneses A M , Schubach A O , Moreira J S , Conceição-Silva F , Salgueiro M M , Pimentel M I F , Araújo-Silva M , Oliveira R V C , Carmo C N , Valete-Rosalino C M 
Published: June 2010

AbstractObjective:To evaluate dizziness in patients receiving meglumine antimoniate for the treatment of mucosal leishmaniasis.Materials and methods:We retrospectively studied 127 patients treated at the Laboratory of Leishmaniasis Surveillance, Evandro Chagas Clinical Research Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, between 1 January 1989 and 31 December 2004.Results:A low dose of meglumine antimoniate (5 mg/kg/day) was used in 86.6 per cent of patients; a dose of 10 mg/kg/day or higher was used in 13.4 per cent of patients. Dizziness was reported by 4.7 per cent of patients. The adjusted odds ratios were 7.37 for dizziness in female patients, 4.9 for dizziness in patients aged 60 years or older, and 7.77 for dizziness in the presence of elevated serum lipase.Conclusion:We suggest that dizziness may be a side effect of meglumine antimoniate, particularly in elderly individuals, in females and in patients with elevated serum lipase.
Histopathological differences in bony destruction of malleus and incus following mastoidectomy
Authors: Sasaki T , Xu A , Ito K , Ishimoto S-I , Yamasoba T , Kaga K , Yamauchi N 
Published: June 2010

AbstractObjectives:Upon direct inspection of surgically removed ossicles from the ears of patients with long-term post-mastoidectomy cavity problems, the extent of malleus destruction often appears greater in patients with a longer duration of cavity problems, whereas the extent of incus destruction does not appear to correlate with the duration of cavity problems. This study aimed to investigate this impression.Materials and methods:As a result of total middle-ear reconstruction, 41 ossicles (21 malleus and 20 incus bones) were obtained from 31 patients with post-mastoidectomy cavity problems. The ossicles were examined histopathologically, and the proportion of lamellar bone area to total bone area (expressed as percentage lamellar bone) was measured. We also calculated the inter-operation time, i.e. the time period between the previous mastoidectomy and the recent total middle-ear reconstruction; this parameter was used as an approximate measure of the duration of the patient's cavity problem. Correlations between percentage lamellar bone and inter-operation time were calculated for the two ossicles.Results:The range of inter-operation times was seven to 65 years. We observed a correlation between percentage lamellar bone and inter-operation time for malleus bones (r = −0.512, p < 0.05), but not for incus bones.Conclusion:These results were in agreement with our pre-study impressions.
Tracheotomy bleeding from an unusual tracheo-arterial fistula: involvement of an aberrant right subclavian artery
Authors: Desvant C , Chevalier D , Mortuaire G 
Published: June 2010

AbstractIntroduction:The development of a tracheo-arterial fistula is a rare but severe complication of tracheotomy. The reported patient presented with such a fistula involving an aberrant right subclavian artery, termed an arteria lusoria, an aortic arch abnormality which is usually asymptomatic.Case report:A 30-year-old man was admitted to our institution for bleeding through his tracheotomy. He had been treated for advanced Duchenne muscular dystrophy, involving invasive assisted ventilation, since the age of 10 years. Surgical exploration and computed tomography scanning revealed a tracheo-arterial fistula involving an aberrant right subclavian artery, associated with severe scoliosis. Emergency, transient haemostasis was achieved by over-inflation of the tracheostomy tube cuff. Aneurysm ablation was successfully achieved as the result of an endovascular interventional radiology procedure.Discussion:Arteria lusoria is one of the most common aortic arch abnormalities. The occurrence of an aneurysm of this artery in a tracheotomised patient has not previously been described. In Duchenne muscular dystrophy patients, spinal deformities may result in thoracic compression, which may alter the anatomical relations of mediastinal vessels. Such deformities are slowly progressive. Thus, vigilance is required in the long term management of Duchenne muscular dystrophy patients with a tracheostomy.
Severe laryngeal fracture treated by supracricoid laryngectomy
Authors: Consalici R , Dall'Olio D 
Published: June 2010

AbstractObjective:To report a rare case of severe laryngeal fracture treated by supracricoid laryngectomy. Previously, a few cases of major laryngeal trauma treated by reconstructive laryngectomy have been briefly described. This paper aims to comprehensively document a rare case of severe laryngeal fracture for which this difficult treatment choice represented an acceptable option.Methods:A 33-year-old woman sustained very serious blunt laryngeal trauma. The complexity of the laryngeal injuries led us to opt for supracricoid laryngectomy, rather than to attempt laryngeal repair.Results:The post-operative course was normal. The patient's post-operative voice was breathy but functional. No airway stenoses occurred.Conclusion:For severe laryngeal fractures, reparative procedures and stenting constitute the standard treatment. However, in selected and especially critical cases, a primary partial or reconstructive laryngectomy is justifiable.
Aspergilloma of the middle ear mimicking necrotising otitis externa: case report
Authors: Rainsbury P , Mitchell-Innes A , Wilson H , Prior M 
Published: June 2010

AbstractObjective:We report a case of a patient who presented with otalgia and facial nerve palsy secondary to an aspergilloma of the middle ear.Case report:A 72-year-old, diabetic man presented to the ENT department with a history of worsening right-sided otalgia, aural discharge and hearing loss, associated with a right-sided facial weakness. This was assumed to be secondary to malignant otitis externa, and treatment was commenced. Imaging showed soft tissue within the middle ear and no bony erosion. Surgical exploration and biopsy revealed an aspergilloma of the middle ear. The pre- and post-operative management, as well as treatment strategies, are discussed.Conclusion:To our knowledge, this is the first documented case of an aspergilloma of the middle ear with associated facial palsy. Readers are asked to consider this rare diagnosis in patients with suspected malignant otitis externa not responding to standard treatment.
The political order in the Arctic: power structures, regimes and influence
Authors: Wegge Njord 
Published: June 2010

ABSTRACTIn the last few years, questions pertaining to cooperation and conflict in the Arctic have emerged in the media, as well as within academia. While many scholars have rightly rejected the prospect of an imminent escalation of conflicts, the current debate is insufficiently informed by the literature on political order within the field of international relations (IR). In this article, the author attempts to explain the political order in the Arctic, situating his analysis within the broader context of IR theory. Guided by the perspectives of ‘hegemonics stability’, ‘balance of power’ and ‘Kantian internationalist theory’, focus is laid on power capabilities, international regimes and domestic regime type as independent variables. The main finding is that the Arctic is a multipolar ‘region,’ the enduring stability and peacefulness of which can be explained by both the role played by international regimes, and by the balance of power between the ‘stakeholders’ involved. The paper concludes by explaining how and why the smaller littoral Arctic states are the prime beneficiaries of this order.