bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract PO5-11-01: Audit of multidisciplinary team meetings for improving breast cancer care
Authors: Sharma Kanika , Puri Gopal 
Published: May 2024

Abstract
Introduction: Multidisciplinary team (MDT) meeting is a well-established method of optimising care for breast cancer patients. However, its effectiveness has not been proven yet. The present study aims to audit the functioning of MDT at a tertiary care hospital in a low-middle income country. Methods: This study examines the prospectively maintained database of patients being discussed in MDT meetings occurring from August 2018 till June 2023. The MDT was suspended for few months in between owing to the COVID pandemic. The analysis was done in terms of indications of discussion, referring department, modification in the pre-MDT plan, new investigation advised, radiological and pathological concordance, significant change in management strategy and interesting cases. The analysis is both qualitative and quantitative. Quantitative analysis involves percentages, mean and median. Results: MDT at our institute was conducted every Saturday at 12 noon as an in-person meeting. The MDT was suspended from May 2020 till June 2021 in view of the pandemic. It was restarted in July 2021, on an online platform and is continued as such. A total of 473 cases were discussed with 181 (38.2%) benign causes and rest were malignant. The most common indication of discussion for malignant cases was feasibility of breast conservation (59.9%) followed by ruling out recurrence/residual disease (17.4%). The indication for benign cases was rad-path concordance and ruling out phyllodes in a case of fibroepithelial lesion. In 31.4% of the cases the plan was modified from the pre-MDT plan and there was improved care. 34.7% cases were advised to get a new investigation done in form of contrast enhanced mammogram or MRI. Seventy nine percent cases were feasible for BCS, and it was done involving few complex surgeries as well. The most common indication for deferring BCS was extensive DCIS. The total number of man hours spent in preparation as well as MDT were analysed with improved clinical care and revealed the MDT to be a time intensive exercise with poor efficacy in terms of hours spent per patient. The time to decision making was increased at an average of 7.5 days for these patients. Conclusion: MDT helps to achieve goals of superior clinical care for both benign and malignant breast disorders at the cost of increased time to decision. It is labour intensive with capability of changing decision in one third of the cases. However, MDT needs regular audit to ensure optimum care with available resources.
Citation Format: Kanika Sharma, Gopal Puri. Audit of multidisciplinary team meetings for improving breast cancer care [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PO5-11-01.
Abstract PO5-15-03: Neutrophil-lymphocyte ratio and absolute lymphocyte count, inflammatory markers, may predict lymph node metastasis in elderly patients with operable breast cancer
Authors: Tokuda Emi , Morita Midori , Shimomura Akihiko , Horimoto Yoshiya , Kawamura Yukino , Ishizuka Yumiko , Sekine Katsutoshi , Obayashi Sayaka , Kojima Yuki , Higuchi Toru 
Published: May 2024

Abstract
Background: Blood-derived systemic inflammatory markers such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR) and absolute lymphocyte count (ALC) have been demonstrated as predictive markers of recurrence and prognosis in several malignancies. Increased chronic inflammation with aging has been reported to be involved in cancer cells and their microenvironment. Several studies have also reported a close relationship between inflammatory markers and cancer grade and prognosis in the elderly. In this study, we retrospectively examined the relationship between lymphocyte-related inflammatory markers and prognosis in elderly breast cancer patients. Method: We included 602 patients diagnosed with primary invasive breast cancer at 8 institutions between 2008 and 2013, all of whom were older than 70 years old and had undergone breast cancer surgery. Preoperative blood collection data were used to analyze the relationship between NLR, PLR, LMR, ALC and clinicopathological data including recurrence. Results: The pathological stages of the 602 patients were Stage I: 275, Stage II: 276, and Stage III: 51, with median NLR, PLR, LMR, and ALC values of 2.21, 134.51, 6.76, and 1840, respectively. The mean age of the patients was 75.3 years. The median follow-up was 72.8 months. 76 patients relapsed, and the mean time to relapse was 42.7 months. Lymphocyte-associated inflammatory markers and Li Sheng pathological characteristics showed no significant differences in stage, presence or absence of recurrence, or form of recurrence, but lymph node metastasis on surgical pathology showed significant differences between cases with and without lymph node metastasis in NLR and ALC (P&lt; 0.05). Conclusions: LMR and ALC were considered useful biomarkers that can be easily measured to predict lymph node metastasis in operable elderly breast cancer
Citation Format: Emi Tokuda, Midori Morita, Akihiko Shimomura, Yoshiya Horimoto, Yukino Kawamura, Yumiko Ishizuka, Katsutoshi Sekine, Sayaka Obayashi, Yuki Kojima, Toru Higuchi. Neutrophil-lymphocyte ratio and absolute lymphocyte count, inflammatory markers, may predict lymph node metastasis in elderly patients with operable breast cancer [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PO5-15-03.
Abstract PS15-08: Final Overall Survival (OS) analysis of the SAKK 21/12 trial. CR1447 in HR+/HER2- metastatic breast cancer and androgen receptor positive triple negative breast cancer
Authors: Vetter Marcus , Lisa Holer , Rothgiesser Karin , Schönfeld Wolfgang , Riniker Salome , von Moos Roger , Torjan Andreas , Kralidis Elena , Rabaglio Manuela , Fehr Mathias K. , Müller Andreas , Thürlimann Beat 
Published: May 2024

Abstract
Introduction:
CR1447 (4-Hydroxytestosteron) is a compound with aromatase inhibitor and anti-androgen receptor activity and is applied transdermally. We assessed its activity and safety in metastatic breast cancer (mBC). The primary endpoint (disease control rate at week 24) was reported in 2019. We now present the final overall survival (OS) analysis of the trial.
Methods
In cohort A (ER+/HER2-negative metastatic disease), one prior treatment line was allowed and 29 patients (ITT 21 patients) were included. In cohort B (triple negative mBC), eight patients were included. The trial was closed in 2018 due to futility (cohort A) and slow accrual (cohort B).
Results
At data cut-off on 11.04.2023 92% of all patients had died. Median OS for cohort A was 35.4 months (95% CI: 24.6-49.1) in the ITT population and 19.4 months (95% CI: 2.3-36.8) in the non-ITT population (patients with more than one line of endocrine therapy). In cohort B, median OS was 10.8 months (95% CI: 3.3-28.6). Treatment was well tolerated with no new safety signals and the majority of treatment-related adverse events (TRAE) were Grade 1 and 2. The most common TRAEs were dry skin (43%), rash (16%), fatigue (16%) and nausea (16%).
Discussion
Despite the trial being negative in terms of the primary endpoint, cohort A (ITT) had a median OS of 35.4 months. There were no new safety signals. Mutational analysis of AR/ER is ongoing to determine benefit of this treatment in specific subgroups. CR1447 might be a candidate drug to combine with other agents (CDK4/6 inhibitors or other targeted therapies).
Citation Format: Marcus Vetter, Holer Lisa, Karin Rothgiesser, Wolfgang Schönfeld, Salome Riniker, Roger von Moos, Andreas Torjan, Elena Kralidis, Manuela Rabaglio, Mathias K. Fehr, Andreas Müller, Beat Thürlimann. Final Overall Survival (OS) analysis of the SAKK 21/12 trial. CR1447 in HR+/HER2- metastatic breast cancer and androgen receptor positive triple negative breast cancer [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PS15-08.
Effects of Recombinant Human Lecithin Cholesterol Acyltransferase on Lipoprotein Metabolism in Humans
Authors: Reyes-Soffer Gissette , Matveyenko Anastasiya , Lignos James , Matienzo Nelsa , Santos Baez Leinys S. , Hernandez-Ono Antonio , Yung Lau , Nandakumar Renu , Singh Sasha A. , Aikawa Masanori , George Richard , Ginsberg Henry N. 
Published: May 2024

BACKGROUND:
LCAT (lecithin cholesterol acyl transferase) catalyzes the conversion of unesterified, or free cholesterol, to cholesteryl ester, which moves from the surface of HDL (high-density lipoprotein) into the neutral lipid core. As this iterative process continues, nascent lipid-poor HDL is converted to a series of larger, spherical cholesteryl ester–enriched HDL particles that can be cleared by the liver in a process that has been termed reverse cholesterol transport.

METHODS:
We conducted a randomized, placebocontrolled, crossover study in 5 volunteers with atherosclerotic cardiovascular disease, to examine the effects of an acute increase of recombinant human (rh) LCAT via intravenous administration (300-mg loading dose followed by 150 mg at 48 hours) on the in vivo metabolism of HDL APO (apolipoprotein)A1 and APOA2, and the APOB100-lipoproteins, very low density, intermediate density, and low-density lipoproteins.

RESULTS:

As expected, recombinant human LCAT treatment significantly increased HDL-cholesterol (34.9 mg/dL;
P
≤0.001), and this was mostly due to the increase in cholesteryl ester content (33.0 mg/dL;
P
=0.014). This change did not affect the fractional clearance or production rates of HDL-APOA1 and HDL-APOA2. There were also no significant changes in the metabolism of APOB100-lipoproteins.

CONCLUSIONS:
Our results suggest that an acute increase in LCAT activity drives greater flux of cholesteryl ester through the reverse cholesterol transport pathway without significantly altering the clearance and production of the main HDL proteins and without affecting the metabolism of APOB100-lipoproteins. Long-term elevations of LCAT might, therefore, have beneficial effects on total body cholesterol balance and atherogenesis.
Intermittent Fasting After ST-Segment–Elevation Myocardial Infarction Improves Left Ventricular Function: The Randomized Controlled INTERFAST-MI Trial
Authors: Dutzmann Jochen , Kefalianakis Zoe , Kahles Florian , Daniel Jan-Marcus , Gufler Hubert , Wohlgemuth Walter Alexander , Knöpp Kai , Sedding Daniel G. 
Published: May 2024

BACKGROUND:
Intermittent fasting has shown positive effects on numerous cardiovascular risk factors. The INTERFAST-MI trial (Intermittent Fasting in Myocardial Infarction) has been designed to study the effects of intermittent fasting on cardiac function after STEM (ST-segment–elevation myocardial infarction) and the feasibility of future multicenter trials.

METHODS:
The INTERFAST-MI study was a prospective, randomized, controlled, nonblinded, single-center investigator-initiated trial. From October 1, 2020, to July 15, 2022, 48 patients were randomized to the study groups intermittent fasting or regular diet and followed for 6 months with follow-up visits at 4 weeks and 3 months.

RESULTS:

In all, 22 of 24 patients in the intermittent fasting group with a mean age of 58.54±12.29 years and 20 of 24 patients in the regular diet group with a mean age of 59.60±13.11 years were included in the intention-to-treat population. The primary efficacy end point (improvement in left ventricular ejection fraction after 4 weeks) was significantly greater in the intermittent fasting group compared with the control group (mean±SD, 6.636±7.122%. versus 1.450±4.828%;
P
=0.038). This effect was still significant and even more pronounced after 3 and 6 months. The patients in the intermittent fasting group showed a greater reduction in diastolic blood pressure and body weight compared with the control group. The mean adherence of patients in the intermittent fasting group was a median of 83.7% (interquartile range, 69.0%–98.4%) of all days. None of the patients from either group reported dizziness, syncope, or collapse.

CONCLUSIONS:
Our results suggest that intermittent fasting after myocardial infarction may be safe and could improve left ventricular function after STEMI.

REGISTRATION:

URL:
https://www.drks.de
; Unique identifier: DRKS00021784.
Taking the Fact/Law Distinction Not Too Seriously: the Status of Domestic Law within International Litigation
Authors: El Boudouhi Saïda 
Published: May 2024

Abstract
The article uses legal theory relating to the traditional distinction between fact and law in order to shed light on the procedural consequences of the consideration that domestic law is a fact in international law. The analysis first relies on formalism, and on the legal syllogism doctrine more specifically, to show that domestic law cannot be, in most cases, anything else than a fact in international legal reasoning. It then draws attention to a constructivist approach to facts according to which domestic law is subject to assessment and interpretation as any other fact is in the judicial process. It paves the way to understanding that the distinction between fact and law for the purposes of the scope of review in the WTO dispute settlement system, as in other appellate systems, is purely functional and must not be taken too seriously, contrary to what is suggested by some analyses of the practice.
When Yiddish Was Written in Latin Letters
Authors: Cohen Roman Oren 
Published: May 2024

Abstract
Although Yiddish was traditionally written in Hebrew letters, texts in this language were also recorded using Latin characters in various circumstances, times, and places. These texts offer valuable information regarding pronunciation traditions and shed light on the processes of cultural history and sociolinguistics that acted as catalysts to their preparation. Various studies have discussed this phenomenon, yet they usually focus on one specific reason for using the Latin alphabet, such as ideological Romanization or linguistic adequacy. The following article offers for the first time a descriptive survey of the entire corpus, from the Early Modern Era to the present day. Paying close attention to the orthography used and the variety recorded, this article discerns within the studied corpus distinct categories reflecting the religious, linguistic, and ideological backgrounds of the texts’ authors and intended readers as well as technical factors pertaining to print. It also highlights the crucial role of the Hebrew alphabet in Yiddish culture.
A Framework for Constraining Ocean Mixing Rates and Overturning Circulation from Age Tracers
Authors: Zhang Boer , Linz Marianna , Sun Shantong , Thompson Andrew F. 
Published: May 2024

Abstract
The age of seawater refers to the amount of time that has elapsed since that water encountered the surface. This age measures the ventilation rate of the ocean, and the spatial distribution of age can be influenced by multiple processes, such as overturning circulation, ocean mixing, and air–sea exchange. In this work, we aim to gain new quantitative insights about how the ocean’s age tracer distribution reflects the strength of the meridional overturning circulation and diapycnal diffusivity. We propose an integral constraint that relates the age tracer flow across an isopycnal surface to the geometry of the surface. With the integral constraint, a relationship between the globally averaged effective diapycnal diffusivity and the meridional overturning strength at an arbitrary density level can be inferred from the age tracer concentration near that level. The theory is tested in a set of idealized single-basin simulations. A key insight from this study is that the age difference between regions of upwelling and downwelling, rather than any single absolute age value, is the best indicator of overturning strength. The framework has also been adapted to estimate the strength of abyssal overturning circulation in the modern North Pacific, and we demonstrate that the age field provides an estimate of the circulation strength consistent with previous studies. This framework could potentially constrain ocean circulation and mixing rates from age-like realistic tracers (e.g., radiocarbon) in both past and present climates.

Significance Statement
The age of seawater—the local mean time since local water from different pathways was last at the surface—is a valuable indicator of ocean circulation and the transport time scale of heat and carbon. We introduce a novel constraint that relates total age flow across a density surface to its geometry, which provides new insights into constraining ocean circulation and mixing rates from age-like realistic tracers (e.g., radiocarbon).
Impact of Safety-Net Hospital Status on Immediate Reconstruction Following Mastectomy: A Contemporary National Analysis
Authors: Curry Joanna , Vadlakonda Amulya , Kim Shineui , Porter Giselle , Balian Jeff , Benharash Peyman , Thompson Carlie K. 
Published: May 2024

Introduction Immediate breast reconstruction (IBR) following mastectomy has been shown to improve quality of life and partially mitigate the adverse psychological impacts associated with the procedure. The present study examined hospital-based and patient-level disparities in utilization and outcomes of IBR following mastectomy. Methods All female adult hospitalizations with a diagnosis of breast cancer undergoing mastectomy were identified in the 2016 to 2020 National Inpatient Sample. Safety-net hospitals (SNH) were defined as those in the top quartile of all Medicaid or self-pay admissions. Patients who underwent mastectomy at SNH comprised the SNH cohort (others: Non-SNH). Multivariable models were developed to examine the impact of SNH status and patient factors on rates of IBR. Results Of an estimated 127,740 hospitalizations, 28,330 (22.2%) were treated at SNH. The proportion of patients receiving IBR increased from 46.7% in 2016 to 51.7% in 2020 (nptrend<.001). Compared to others, SNH were younger (57.9 ± 13.5 vs 58.3 ± 13.5 years) and less commonly White (45.6 vs 69.9%) (all P < .001). Additionally, SNH were more likely to receive unilateral mastectomy (67.1 vs 55.2%) but less frequently underwent IBR (37.7 vs 51.5%) (all P < .001). After adjustment, Black and Asian race, SNH, and bilateral mastectomy were associated with decreased odds of IBR. Increasing IBR hospital volume did not eliminate the observed racial disparity at non-SNH or SNH. Conclusion There are disparities in rates of IBR following mastectomy attributable to SNH status. Future work is needed to ensure all patients have access to reconstructive care irrespective of payer status or the hospital at which they receive care.
Consequences of COVID-19 Vaccine Hesitancy Among Healthcare Providers During the First 10 Months of Vaccine Availability: Scoping Review
Authors: Wilpstra Caitlyn D. , Morrell Sherry , Mirza Noeman A. , Ralph Jody L. 
Published: May 2024

Background Throughout the COVID-19 pandemic, healthcare providers (HCPs)—including nurses—have played important roles in the vaccination effort. It is expected that COVID-19 vaccine hesitancy among HCPs has numerous consequences; however, the scope of these consequences and their impacts on providers, patients, and the broader healthcare system remained unclear. Purpose To identify existing and emerging evidence to understand the state of knowledge of the consequences of COVID-19 vaccine hesitancy among HCPs. Methods A scoping review was completed based upon the JBI scoping review methodology. The databases searched included OVID Medline, EBSCOhost CINAHL, ProQuest Nursing and Allied Health Source, ProQuest APA PsycInfo, and ProQuest Dissertations and Theses. The final literature search was completed on June 2, 2022. Studies were screened and retrieved based on predefined inclusion and exclusion criteria using Covidence reference management software. Data extraction followed criteria recommended in the JBI scoping review framework with additional relevant variables identified by the authors. Results A total of 33 sources were included in the review. Consequences of HCP COVID-19 vaccine hesitancy were grouped under three themes and seven subthemes. Consequences affecting HCPs included health-related, psychosocial, and employment-related consequences. Consequences affecting patients pertained to COVID-19 vaccination communication and COVID-19 vaccination practices of HCPs. Consequences to the healthcare system involved consequences to coworkers and employment/attendance/staffing-related consequences. Conclusions Healthcare provider COVID-19 vaccine hesitancy was found to have numerous consequences. By understanding the scope and extent of these consequences, healthcare leaders, researchers, and HCPs can work together to protect providers, patients, and healthcare systems.
The Interests of Three Stakeholders in Independent Personal Care for Disabled Elders
Authors: Keigher Sharon M. 
Published: May 2024

There is concern throughout developed countries about how sufficient services can be mounted in this century to care for all older, disabled persons who want to remain at home. With declining availability of family care and high turnover among paid workers, cost, care supply, and quality dilemmas abound. Therefore, how can home care be improved? One suggestion is to revise the care “contract” by simply eliminating the costly bureaucratic and controlling dimensions of agency oversight and management. In consumer-directed or self-managed care, independent workers are hired directly by consumers or their family members. Consumers spend their own private money or government provides authorization for them to “hire” their own workers. Such arrangements may be more responsive to the needs of consumers, more directly accountable to them, and less costly for both individuals and government. This article examines 41 cases of consumer-directed care in Milwaukee. Extended interviews with three “stakeholders” in care—the disabled, older client, the family caregiver, and the personal assistant—were conducted, including both private pay and government subsidized arrangements. This analysis identifies some essential, but disparate interests of the three partners in care.
Taxing Owner-Occupied Housing: Comparing the Netherlands to Other European Union Countries
Authors: van der Hoek M. Peter , Radloff Sarah E. 
Published: May 2024

This paper compares owner-occupied housing tax regimes in the Netherlands and the other countries in the EU-15. the Netherlands appears to stand apart in two respects. First, in Luxembourg and the Netherlands owner-occupiers have to include an imputed rental income in their taxable income. Second, in the Netherlands, the tax-deductibility of mortgage interest payments is almost unrestricted. The tax regime of owner-occupied homes increasingly erodes the personal income tax base in the Netherlands, so that higher tax rates are needed to collect a given amount of revenue. However, elimination or reduction of the mortgage interest deduction can only be realized gradually. Due to a lack of data both within the various tax regimes and across time periods, a comprehensive multivariate time-series comparison among the various tax regimes in the EU-15 is not possible. Thus, the statistical analysis is limited to bivariate comparisons.