bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inquiring Into the Possibilities of Multimodal Novel Study: Teacher Candidates Respond to Whirligig With Resolution Scrapbooks
Authors: Morawski Cynthia Marlene 
Published: January 2012

AbstractTo underscore the importance of using multiple means of engagement in adolescent novels, the author invited the teacher candidates in one of her intermediate English methods classes to use the resolution scrapbook<em>a reflective and multimodal chronicling of an individual's response to trauma<em>to study the coming‐of‐age novelWhirligig, by Paul Fleischman. The teacher candidates constructed six‐page resolution scrapbooks in which they responded to the protagonist's retribution journey by using multiple forms of expressions and representations in relation to past and current contexts of his life, thereby entering into the story and making meaning of the protagonist's dilemma.
Visual Literacy as a Classroom Approach
Authors: Rowsell Jennifer , McLean Cheryl , Hamilton Mary 
Published: January 2012

AbstractLiving in an increasingly visual culture, Rowsell, McLean, and Hamilton illustrate the importance of critically evaluating the potential of visual literacy as a dimension of the school context. They first situate visual literacy within the school arena and then examine its relevance to learning through different visual genres. In an effort to illustrate the power of visual literacy to enhance cross‐curricular learning, the authors conclude by sharing examples of students conceptualizing and extrapolating visual literacy through the consumption and production of texts.
Biological treatment of a mixture of gaseous sulphur reduced compounds: identification of the total bacterial community's structure
Authors: Soupramanien Alexandre , Malhautier Luc , Dumont Eric , Andrès Yves , Rocher Jannick , Fanlo Jean‐Louis 
Published: January 2012

AbstractBACKGROUND: This study deals with the potential of biological processes combining biofiltration and a biotrickling filter to treat a mixture of sulphur reduced compounds (SRC) including dimethylsulfide (DMS), dimethyldisulfide (DMDS) and hydrogen sulphide (H2S). The first step in this work is to evaluate the influence of pH on SRC biodegradation in microcosms seeded with planktonic biomass from activated sludge of a rendering facility. In a second step, for each tested pH, evaluation of the influence of pH on total bacterial community diversity and structure has been investigated using denaturing gradient gel electrophoresis (DGGE).RESULTS: At pH 7 and 5, H2S, DMS and DMDS were completely removed. In return, the abatement of DMS and DMDS is low, around 20%, for pH 3 and pH 1 microcosms. The selective pressure imposed in the microcosms (concentration and pH) is sufficient to influence strongly the community diversity and composition. The inoculum community seems to make a significant contribution to the 67‐day community in the considered pH microcosms.CONCLUSION: These results suggest that distinct communities from different inocula can achieve high and stable functionality. The results obtained provide relevant information for improving the treatment of different SRC using biotrickling filter/biofilter combination. Copyright © 2012 Society of Chemical Industry
Two‐dimensional speckle tracking echocardiography of acute cardiac transplant rejection following pregnancy
Authors: Lisi Matteo , Cameli Matteo , Tacchini Damiana , Ballo Piercarlo , Maccherini Massimo , Mondillo Sergio 
Published: January 2012

AbstractA 44‐year‐old woman, who had undergone orthotopic cardiac transplantation in 1999, presented acute allograft rejection 4 months after childbirth. Analysis of myocardial deformation by speckle tracking echocardiography showed, in contrast with traditional markers of systolic function, a strong reduction of left ventricular strain, which recovered, together with rejection, under pharmacological treatment. This case documents the potential advantages of speckle tracking echocardiography in the noninvasive management of transplant recipients. © 2012 Wiley Periodicals, Inc. J Clin Ultrasound 40:451–454, 2012
Evaluation of finger joint synovial vascularity in patients with rheumatoid arthritis using contrast‐enhanced ultrasound with water immersion and a stabilized probe
Authors: Stramare Roberto , Raffeiner Bernd , Ciprian Luca , Scagliori Elena , Coran Alessandro , Perissinotto Egle , Fiocco Ugo , Beltrame Valeria , Rubaltelli Leopoldo 
Published: January 2012

AbstractPurpose.To assess synovial microvascularity in finger joints with rheumatoid arthritis (RA) by contrast‐enhanced ultrasound (CEUS), distinguishing between cases of active disease and those in remission; to standardize the technique for software analysis.Methods.Fifty‐two finger joints of RA patients (26 with active disease and 26 in remission) were immersed in water and examined by CEUS using a fixed probe. Signal intensity curves were calculated with the software.Results.Contrast enhancement was detectable in all 26 patients with active RA (100%), but not in 25 of 26 patients in remission (96%); one of the latter patients (4%) showed minimal enhancement. The method's sensitivity and specificity in distinguishing active disease from remission were 100% and 96%. The grades of synovial enhancement correlated with clinical disease activity and software flow parameters. The peak contrast levels correlated with clinical activity, a peak of 9% representing the cutoff between remission and active disease.Conclusions.CEUS with a fixed probe on finger joints immersed in water detected synovial vascularization in RA, producing results suitable for standardized software analysis and avoiding artifacts. © 2012 Wiley Periodicals, Inc. J Clin Ultrasound, 2012
Neonatal testicular torsion with an unusual sonographic feature
Authors: Singhal Aparna , Agarwal Ambika , Metuge Joelle , Olsavsky Thomas 
Published: January 2012

AbstractNeonatal testicular torsion is a rare entity, the exact etiology of which is not elucidated. Imaging is performed using color Doppler ultrasound and scintigraphic studies with typically diminished testicular flow on the side with torsion. We present a case of testicular torsion in a newborn with increased testicular vascularity demonstrated by ultrasound and suggesting a torsion‐detorsion sequence. Management of patients with torsion involves assessing the risks of neonatal surgery versus the possibility offinding viable testicular tissue at surgical exploration. © 2012 Wiley Periodicals, Inc. J Clin Ultrasound, 2012
Differences in the carotenoid content of ketchups and gazpachos through HPLC/ESI(Li+)‐MS/MS correlated with their antioxidant capacity
Authors: Vallverdú‐Queralt Anna , Martínez‐Huélamo Miriam , Arranz‐Martinez Sara , Miralles Esther , Lamuela‐Raventós Rosa M 
Published: January 2012

AbstractBACKGROUND: Carotenoids are important antioxidant compounds in the human diet. Owing to their constrained polyene structure, carotenoids can exist in cis and trans isomeric forms that can be difficult to differentiate in natural samples. In ketchups and gazpachos, all‐trans isomeric forms are predominant. However, during thermal processing, cis isomers are formed. Therefore the determination of carotenoid isomers is required for the assessment of the nutritional value of foods.RESULTS: The main carotenoid found in ketchups was trans‐lycopene, whereas in gazpachos a higher contribution to the total carotenoid content was made by other carotenoids such as 5‐, 9‐ and 13‐cis‐lycopene, lutein, β‐carotene and α‐carotene. Ketchups exhibited the highest lipophilic antioxidant content owing to their higher content of trans‐lycopene, the main carotenoid in tomatoes.CONCLUSION: Direct analysis of carotenoids by electrospray ionisation mass spectrometry (ESI‐MS) often produces poor results requiring offline time‐ and sample‐consuming derivatisation techniques. Therefore in this work a simple ESI‐MS approach is described for the direct analysis of carotenoids in ketchups and gazpachos using the post‐column addition of lithium chloride to promote the cationisation of carotenoids. To the best of the authors' knowledge, this paper presents for the first time the identification of 5‐, 9‐ and 13‐cis‐lycopene in ketchups and gazpachos. Copyright © 2012 Society of Chemical Industry
Multispecies laser measurements of n‐butanol pyrolysis behind reflected shock waves
Authors: Cook Robert D. , Davidson David F. , Hanson Ronald K. 
Published: January 2012

AbstractTime histories of OH, H2O, and 306.8 nm absorbance were measured behind reflected shock waves in mixtures of 1% n‐butanol in Ar. Reflected shock conditions covered temperatures (T5) from 1274 to 1439 K and pressures (P5) near 1.5 atm. OH was measured using laser absorption of the R1(5) line of the A–X (0, 0) transition at 306.7 nm. Each experiment was repeated with the laser tuned off the narrow OH absorption feature to subtract broadband interference from CH2O and CH3CHO. Knowledge of the absorption coefficients of CH2O and CH3CHO at this nonresonant wavelength was then used to compare ultraviolet (UV) absorbance to model predictions. H2O was measured using DFB diode laser absorption of a well‐characterized absorption feature near 2.5 μm. These measured time histories, which should prove highly useful in reaction mechanism development, were then compared to simulations based on the comprehensive n‐butanol oxidation mechanism by Curran et al. (Combust Flame, 2010, 157, 363–373). Using that mechanism, it was determined that the n‐butanol decomposition pathways through C4H8OH(γ) should be strongly favored over C4H8OH(α) and that the C4H8OH(δ) pathway should also be increased by 25%. The specific rate adjustments inferred in this work were found to be highly mechanism dependent, though the overall reaction path analyses were very similar for all the mechanisms studied. In addition to Curran et al. (2010), two other mechanisms were examined, revealing the importance of four specific sets of reactions in n‐butanol pyrolysis. © 2012 Wiley Periodicals, Inc. Int J Chem Kinet 44: 303–311, 2012
Structure activity relationship of plumbagin in BRCA1 related cancer cells
Authors: K.A. Thasni , T. Ratheeshkumar , G. Rojini , K.C. Sivakumar , Nair Rakesh Sathish , G. Srinivas , Banerji Asoke , Somasundaram Veena , Srinivas Priya 
Published: January 2012

AbstractIt has been shown earlier that plumbagin, a naturally occurring naphthaquinone has specific anticancer activity in BRCA1 blocked ovarian cancer cells. Plumbagin can induce estrogen dependent cell signaling and apoptosis in BRCA1 blocked ovarian cancer cells. Being a reactive oxygen species (ROS) generator and apoptosis inducing agent, plumbagin has immense potential as a promising anticancer agent. In this study we analyzed whether there would be increased anticancer activity if the positions of the functional groups on plumbagin were altered and further to analyze the detailed molecular mechanism of action of the lead molecule. Methods like MTT assay, apoptosis analysis by flow cytometry, assessment of mitochondrial membrane potential‐Δψm, suppression subtractive hybridization, microarray, molecular docking and estrogen receptor–DNA binding activity by electrophoresis mobility shift assay (EMSA) were adopted for assessing the anticancer activity. Consequently we found that, plumbagin was the most potent anticancer agent when compared to structurally related compounds. The anti‐cancer activities were in the order plumbagin > 1,4‐naphthaquinone > juglone > lawsone > menadione. Molecular docking studies showed that plumbagin could be well docked in the receptor ligand complex of TRAIL–DR5 complexes to activate the extrinsic pathway of apoptosis. Since the antiproliferative activity of plumbagin could be reduced by inhibiting ERα, we speculated that plumbagin interferes with the binding of ERα to ERE and we confirmed this by EMSA. This study clearly indicates that plumbagin can induce multiple pathways of apoptosis and cell cycle arrest in BRCA1 blocked cells compared to unblocked cells. © 2012 Wiley Periodicals, Inc.
Significance and usefulness of heart rate variability in patients with multiple system atrophy
Authors: Furushima Hiroshi , Shimohata Takayoshi , Nakayama Hideaki , Ozawa Tetsutaro , Chinushi Masaomi , Aizawa Yoshifusa , Nishizawa Masatoyo 
Published: January 2012

AbstractBackground:The purpose of this study was to investigate whether heart rate variability parameters can be useful for evaluating cardiac autonomic dysfunction in multiple system atrophy patients.Methods:Both the time and frequency domains of heart rate variability were investigated among 17 multiple system atrophy patients and 27 normal control subjects.Results:All time‐ and frequency‐domain measures, except the low‐ to high‐frequency ratio, were significantly lower in multiple system atrophy patients than in controls. In multiple system atrophy patients, there were significant inverse correlations between heart rate variability parameters and disease duration, as well as disease severity, but heart rate variability parameters were not affected by other autonomic dysfunctions.Conclusions:The cardiac autonomic state of multiple system atrophy was characterized by decreases in both sympathetic and parasympathetic tones. Because heart rate variability parameters were not affected by other autonomic dysfunctions, this may be a useful method for evaluating cardiac autonomic dysfunction in multiple system atrophy. © 2012 Movement Disorder Society
A shrinkage‐based comparative assessment of observed‐to‐expected disproportionality measures
Authors: Gipson Geoffrey 
Published: January 2012

ABSTRACTPurposeDisproportionality analysis is an important tool for interpreting spontaneous adverse event reports in pharmacovigilance. There exist a variety of disproportionality measures (DPMs) for use in safety signaling; however, it is not always clear which method is best suited for a particular need. A framework for comparing the various DPMs is necessary to fully understand the consequences of quantitative signal detection implementation decisions. Here, the mathematical relationship between these measures is explored through a comparison of the underlying equations and a shrinkage approach is adopted to further clarify these relationships.MethodsMany DPMs take the form of a ratio of the number of observed (O) cases and the number of expected (E) cases (i.e.,O/E). BecauseOis unchanged by the method selected, the method‐specificE(EDPM) is the fundamental difference between the values produced by these DPMs. Clarification of the relationship between these DPMs is pursued through the use of a shrinkage parameter (s).ResultsIt is demonstrated that any arbitrary DPM, which can be defined asO/EDPM, can also be expressed as a function of the reporting odds ratio (ROR) ands. This common equation allows for a straightforward comparison of the varying methods and the ability to clearly characterize the approaches according to their relative signal detection performance irrespective of the specific dataset to which the methods are applied. A novel DPM, the independent reporting ratio (IRR), provides an example of how the described framework can improve our understanding of disproportionality analyses and lead to the development of new methods.ConclusionsExplicitly defining DPMs as RORs with applied shrinkage provides a convenient method for understanding their relative signal detection performance and insight into the relative contributions to DPM shrinkage. Copyright © 2012 John Wiley & Sons, Ltd.
Solution‐processed Cu(In,Ga)(S,Se)2 absorber yielding a 15.2% efficient solar cell
Authors: Todorov Teodor K. , Gunawan Oki , Gokmen Tayfun , Mitzi David B. 
Published: January 2012

ABSTRACTThe remarkable potential for inexpensive upscale of solution processing technologies is expected to enable chalcogenide‐based photovoltaic systems to become more widely adopted to meet worldwide energy needs. Here, we report a thin‐film solar cell with solution‐processed Cu(In,Ga)(S,Se)2 (CIGS) absorber. The power conversion efficiency of 15.2% is the highest published value for a pure solution deposition technique for any photovoltaic absorber material and is on par with the best nonvacuum‐processed CIGS devices. We compare the performance of our cell with a world champion vacuum‐deposited CIGS cell and perform detailed characterization, such as biased quantum efficiency, temperature‐dependent electrical measurement, time‐resolved photoluminescence, and capacitance spectroscopy. Copyright © 2012 John Wiley & Sons, Ltd.
Translational Proteomics in Neurodegenerative Diseases – 16th HUPO BPP Workshop September 5, 2011, Geneva, Switzerland
Authors: Gröttrup Bernd , Böckmann Miriam , Stephan Christian , Marcus Katrin , Grinberg Lea T. , Meyer Helmut E. , Park Young Mok 
Published: January 2012

AbstractThe HUPO Brain Proteome Project (HUPO BPP) held its 16th workshop in Geneva, Switzerland, on September 5, 2011 during the 10th HUPO World Congress. The focus was on launching the Human Brain Proteome Atlas as well as ideas, strategies and methodological aspects in clinical neuroproteomics.
Goal adjustment, physical and sedentary activity, and well‐being and health among breast cancer survivors
Authors: Wrosch Carsten , Sabiston Catherine M. 
Published: January 2012

AbstractObjectiveThis longitudinal study examined whether goal adjustment capacities (i.e., goal disengagement and goal reengagement) would predict breast cancer survivors' emotional well‐being and physical health by facilitating high levels of physical activity and low levels of sedentary activity.MethodsSelf‐reports of goal adjustment capacities were measured among 176 female breast cancer survivors at baseline. Self‐reports of physical activity, sedentary activity, daily affect, and daily physical health symptoms (e.g., nausea or pain) were measured at baseline and 3‐month follow‐up.ResultsGoal reengagement predicted high levels of positive affect and low levels of physical symptoms at baseline and increases in positive affect over 3 months. The combination of high goal disengagement and high goal reengagement was associated with particularly large 3‐month increases in positive affect. The effects of goal reengagement on baseline affect and physical health were mediated by high baseline levels of physical activity, and the interaction effect on 3‐month changes in positive affect was mediated by low baseline levels of sedentary activity.ConclusionsGoal adjustment capacities can exert beneficial effects on breast cancer survivors' well‐being and physical health by facilitating adaptive levels of physical and sedentary activity. Integrating goal adjustment processes into clinical practice may be warranted. Copyright © 2012 John Wiley & Sons, Ltd.
Maternal smoking during pregnancy, prematurity and recurrent wheezing in early childhood
Authors: Robison Rachel G. , Kumar Rajesh , Arguelles Lester M. , Hong Xiumei , Wang Guoying , Apollon Stephanie , Bonzagni Anthony , Ortiz Kathryn , Pearson Colleen , Pongracic Jacqueline A. , Wang Xiaobin 
Published: January 2012

AbstractBackgroundPrenatal maternal smoking and prematurity independently affect wheezing and asthma in childhood.ObjectiveWe sought to evaluate the interactive effects of maternal smoking and prematurity upon the development of early childhood wheezing.MethodsWe evaluated 1,448 children with smoke exposure data from a prospective urban birth cohort in Boston. Maternal antenatal and postnatal exposure was determined from standardized questionnaires. Gestational age was assessed by the first day of the last menstrual period and early prenatal ultrasound (preterm < 37 weeks gestation). Wheezing episodes were determined from medical record extraction of well and ill/unscheduled visits. The primary outcome was recurrent wheezing, defined as ≥ 4 episodes of physician documented wheezing. Logistic regression models and zero inflated negative binomial regression (for number of episodes of wheeze) assessed the independent and joint association of prematurity and maternal antenatal smoking on recurrent wheeze, controlling for relevant covariates.ResultsIn the cohort, 90 (6%) children had recurrent wheezing, 147 (10%) were exposed to in utero maternal smoke and 419 (29%) were premature. Prematurity (odds ratio [OR] 2.0; 95% confidence interval [CI], 1.3–3.1) was associated with an increased risk of recurrent wheezing, but in utero maternal smoking was not (OR 1.1, 95% CI 0.5–2.4). Jointly, maternal smoke exposure and prematurity caused an increased risk of recurrent wheezing (OR 3.8, 95% CI 1.8–8.0). There was an interaction between prematurity and maternal smoking upon episodes of wheezing (P = 0.049).ConclusionsWe demonstrated an interaction between maternal smoking during pregnancy and prematurity on childhood wheezing in this urban, multiethnic birth cohort. Pediatr Pulmonol. 2012; 47:666–673. © 2012 Wiley Periodicals, Inc.
Induced heterodimerization and purification of two target proteins by a synthetic coiled‐coil tag
Authors: Fernandez‐Rodriguez Jesus , Marlovits Thomas C. 
Published: January 2012

AbstractA synthetic de novo designed heterodimeric coiled‐coil was used to copurify two target fluorescent proteins, Venus and enhanced cyan fluorescent protein (ECFP). The coiled‐coil consists of two 21‐amino acid repetitive sequences, (EIAALEK)3 and (KIAALKE)3, named E3 and K3, respectively. These sequences were fused to the C‐termini of ECFP or Venus followed by either a strep‐ or a his‐tag, respectively, for affinity purification. Mixed lysates of Venus‐K3 and ECFP‐E3 were subjected to consecutive affinity purification and showed highly specific association between the coiled‐coil pair by SDS‐PAGE, gel filtration, isothermal titration calorimetry (ITC), and fluorescence resonance energy transfer (FRET). The tagged proteins eluted as heterodimers at the concentrations tested. FRET analysis further showed that the coiled‐coil pair was stable in buffers commonly used for protein purification, including those containing high salt concentration and detergent. This study shows that the E3/K3 pair is very well suited for the copurification of two target proteins expressed in vivo because of its high specificity: it forms exclusively heterodimers in solution, it does not interact with any cellular proteins and it is stable under different buffer conditions.