bluuebunny/crossref_metadata_2025_split huggingface dataset:
Low anterior resection with transanal transection and single-stapled anastomosis: technical aspects and initial results
Authors: Vivas López Alfredo , Villar Oscar Garcia , Borda Javier Garcia , Restrepo Nuñez Rafael , Rubio Eduardo , Nevado Cristina , Pelaez Pablo , Labalde Martinez Maria , Alias David , Falcon Kleber , Lorenzo Sofia , Perea García José , Ferrero Eduardo 
Published: June 2024

Abstract
Background
Rectal cancer (RC) is a surgical challenge due to its technical complexity. The double-stapled (DS) technique, a standard for colorectal anastomosis, has been associated with notable drawbacks, including a high incidence of anastomotic leak (AL). Low anterior resection with transanal transection and single-stapled (TTSS) anastomosis has emerged to mitigate those drawbacks.

Methods
Observational study in which it described the technical aspects and results of the initial group of patients with medium-low RC undergoing elective laparoscopic total mesorectal excision (TME) and TTSS.

Results
Twenty-two patients were included in the series. Favourable postoperative outcomes with a median length of stay of 5 days and an AL incidence of 9.1%. Importantly, all patients achieved complete mesorectal excision with tumour-free margins, and no mortalities were reported.

Conclusion
TTSS emerges as a promising alternative for patients with middle and lower rectal tumours, offering potential benefits in terms of morbidity reduction and oncological integrity compared with other techniques.
Two doses of fosaprepitant included prophylactic treatment for the three-day cisplatin-based chemotherapy induced nausea and vomiting
Authors: Li Yanying , Wan Yuming , Yang Xiaoyun , Chen Ping , Gui Yan , He Lang , Xie Yingwei , Tian Jing , Duan Ping , Liu Guangguo , Sun Yu , Zhu Jiang 
Published: June 2024

Abstract
Purpose
Neurokinin 1 receptor antagonists included prophylactic treatment was recommended for patients who receive one-day cisplatin chemotherapy. It is unclear whether the prolonged administration of fosaprepitant is effective for three-day cisplatin-based chemotherapy induced nausea and vomiting (CINV). We aim to explore the prophylactic antiemetic efficacy and safety of two doses of fosaprepitant included regimen in the patients receiving multiple-day cisplatin chemotherapy.

Methods
This randomized, parallel-group, open-labelled study was conducted in nine hospitals between February 2021 and February 2023. Patients diagnosed as lung cancer and chemotherapy naive were screened. Eligible participants were scheduled to be treated with highly emetogenic chemotherapy regimen which including three days of cisplatin. Then they were randomly divided into the experimental group (two doses of fosaprepitant, Group 2DF) and the control group (one dose of fosaprepitant, Group C). The primary endpoints included the safety and the average none CINV days (NCDs). This study was registered on the website of chictr.org.cn, number ChiCTR2100042665.

Results
Overall, 204 participants were randomly assigned, and 198 patients were analyzed. No statistical difference in adverse events was found between the two groups. All treatment-related adverse effects for fosaprepitant observed were of grade 1–2. The average NCDs of Group 2DF was significantly more than Group C (18.21 ± 3.40 days vs 16.14 ± 5.20 days, P = 0.001). Furthermore, the better life function score was achieved in Group 2DF according to FLIE questionnaire.

Conclusion
The administration of two-dose fosaprepitant was safe and more effective than one dose in protecting patients from CINV induced by three-day cisplatin included chemotherapy.
Regularized mean curvature flow for invariant hypersurfaces in a Hilbert space and its application to gauge theory
Authors: Koike Naoyuki 
Published: June 2024

AbstractIn this paper, we investigate a regularized mean curvature flow starting from an invariant hypersurface in a Hilbert space equipped with an isometric and almost free action of a Hilbert Lie group whose orbits are minimal regularizable submanifolds. We prove that, if the initial invariant hypersurface satisfies a certain kind of horizontally convexity condition and some additional conditions, then it collapses to an orbit of the Hilbert Lie group action along the regularized mean curvature flow. In the final section, we state a vision for applying the study of the regularized mean curvature flow to the gauge theory.
Effect of flexible membrane in triaxial test on the mechanical behaviour of rockfill material using Discrete Element Method
Authors: Asadi Reza , Disfani Mahdi M. , Ghahreman-Nejad Behrooz , Ciantia Matteo O. 
Published: June 2024

AbstractThe investigation of rockfill materials poses challenges due to their large particle size, associated high cost, and long laboratory testing duration. As a result, empirical correlations based on historical experimental studies are commonly used to design and analyse rockfill structures. However, the extensive use of rockfill in a wide range of applications and limited understanding of its mechanical behaviour emphasize the need for further research. These make it necessary to develop a robust technique capable of capturing key parameters such as particle shape and breakage, allowing for the simulation and study of large-scale assemblies with realistic boundary conditions. Given that the behaviour of rockfill is highly scale-dependent, primarily due to particle breakage, the simplified laboratory tests on the scaled-down assemblies can be misleading. Particle breakage is a fundamental phenomenon in the mechanical behaviour of rockfill and significantly affects shear strength, deformability, and porosity under different stress levels. The particle breakage is influenced by factors such as the rockfill’s maximum particle size, mineralogy, particle shape, gradation, and confining stresses. This study adopts a computationally efficient breakage method called the Modified Particle Replacement Method (MPRM) based on the Discrete Element Method. A Tile-Based Flexible Membrane (TBFM) for triaxial test modelling has been developed by employing segmental rectangular walls to create a deformable membrane. The effects of critical parameters, including particle shape, confining stress, membrane resolution, degree of flexibility, and the characteristic strength of the particles, are examined. The findings of the combined MPRM-TBFM approach demonstrate the significant influence of membrane flexibility on volumetric-related behaviour.
Graphical Abstract
Effectiveness of laser pulsed irradiation for antimicrobial photodynamic therapy
Authors: Sueoka Kentaro , Chikama Taiichiro , Shinji Koichiro , Kiuchi Yoshiaki 
Published: June 2024

Abstract
The aim of this study was to compare two types of light irradiation devices for antimicrobial photodynamic therapy (aPDT). A 660-nm light-emitting diode (LED) and a 665-nm laser diode (LD) were used for light irradiation, and 0.1 mg/L TONS 504, a cationic chlorin derivative, was used as the photosensitizer. We evaluated the light attenuation along the vertical and horizontal directions, temperature rise following light irradiation, and aPDT efficacy against Staphylococcus aureus under different conditions: TONS 504 only, light irradiation only, and TONS 504 with either LED (30 J/cm2) or LD light irradiation (continuous: 30 J/cm2; pulsed: 20 J/cm2 at 2/3 duty cycle, 10 J/cm2 at 1/3 duty cycle). Both LED and LD light intensities were inversely proportional to the square of the vertical distance from the irradiated area. Along the horizontal distance from the nadir of the light source, the LED light intensity attenuated according to the cosine quadrature law, while the LD light intensity did not attenuate within the measurable range. Following light irradiation, the temperature rise increased as the TONS 504 concentration increased in the order of pulsed LD < continuous LD < LED irradiation. aPDT with light irradiation only or TONS 504 only had no antimicrobial effect, while aPDT with TONS 504 under continuous or pulsed LD light irradiation provided approximately 3 log reduction at 30 J/cm2 and 20 J/cm2 and approximately 2 log reduction at 10 J/cm2. TONS 504-aPDT under pulsed LD light irradiation provided anti-microbial effect without significant temperature rise.
Prediction of Follicular Thyroid Neoplasm and Malignancy of Follicular Thyroid Neoplasm Using Multiparametric MRI
Authors: Song Bin , Zheng Tingting , Wang Hao , Tang Lang , Xie Xiaoli , Fu Qingyin , Liu Weiyan , Wu Pu-Yeh , Zeng Mengsu 
Published: June 2024

AbstractThe study aims to evaluate multiparametric magnetic resonance imaging (MRI) for differentiating Follicular thyroid neoplasm (FTN) from non-FTN and malignant FTN (MFTN) from benign FTN (BFTN). We retrospectively analyzed 702 postoperatively confirmed thyroid nodules, and divided them into training (n = 482) and validation (n = 220) cohorts. The 133 FTNs were further split into BFTN (n = 116) and MFTN (n = 17) groups. Employing univariate and multivariate logistic regression, we identified independent predictors of FTN and MFTN, and subsequently develop a nomogram for FTN and a risk score system (RSS) for MFTN prediction. We assessed performance of nomogram through its discrimination, calibration, and clinical utility. The diagnostic performance of the RSS for MFTN was further compared with the performance of the Thyroid Imaging Reporting and Data System (TIRADS). The nomogram, integrating independent predictors, demonstrated robust discrimination and calibration in differentiating FTN from non-FTN in both training cohort (AUC = 0.947, Hosmer-Lemeshow P = 0.698) and validation cohort (AUC = 0.927, Hosmer-Lemeshow P = 0.088). Key risk factors for differentiating MFTN from BFTN included tumor size, restricted diffusion, and cystic degeneration. The AUC of the RSS for MFTN prediction was 0.902 (95% CI 0.798–0.971), outperforming five TIRADS with a sensitivity of 73.3%, specificity of 95.1%, accuracy of 92.4%, and positive and negative predictive values of 68.8% and 96.1%, respectively, at the optimal cutoff. MRI-based models demonstrate excellent diagnostic performance for preoperative predicting of FTN and MFTN, potentially guiding clinicians in optimizing therapeutic decision-making.
Neighbours under the North Star: Civil wars in Finland and Korea
Authors: Park-Kang Sungju 
Published: June 2024

AbstractThe article has two objectives. The first one is to advance the existing studies on civil wars by developing a comparative approach. It explores similarities and differences between the Finnish and Korean experiences. The broader objective of the article is to initiate a project to explore potential connections between the Nordic region and the Korean peninsula. There are various direct and indirect linkages between the Nordic countries and Korea. Finland had long been part of Sweden and then part of Russia. Finland achieved independence, but it was immediately overshadowed by the war. Korea had long been influenced heavily by China and then colonised by Japan. Independence brought sunshine on the peninsula, but it soon disappeared with the Korean War. Against this backdrop, the article investigates the civil wars in Finland and Korea. In order to go beyond the existing research, the article pays attention to popular culture (film) depicting the two wars. The article also sheds light on how Finland and Korea have tried to pave the way to reconciliation. If the war still divides Finland even after 100 years, the reconciliation process in Korea would be much more complex and difficult.
Feasibility of complex exercise therapy with Standing Ovation and peripheral neuromodulation for gait rehabilitation after incomplete spinal cord injury—a case report
Authors: Pataraia Anna , Mayr Winfried , Vargas Luna Jose Luis , Sternik Julia , Crevenna Richard 
Published: June 2024

Summary

Background
Spinal cord injuries (SCIs) are a global concern, annually affecting hundreds of thousands of individuals. Among these cases, incomplete SCIs, allowing some muscle activity below the injury, pose unique challenges. This case study focuses on a 55-year-old male with a moderate incomplete SCI (AIS-D).

Case presentation
After initial treatments and pharmaceutical antispastic therapy, a novel intervention was introduced featuring the Standing Ovation gait exercise system (Standing Ovation GmbH, Hallwang, Austria). This individually tailored system, equipped with a rail system and seat-lifting unit, provided a secure environment for balance training. Over 14 training sessions spanning from October 13, 2021, to March 23, 2022, improvements in functional walking were observed.

Discussion and conclusion
Locomotor improvement in SCI rehabilitation is important; the potential of task-specific gait exercises with the Standing Ovation system in incomplete spinal cord injury seems to be a promising approach. Although promising, these findings call for further systematic studies with larger patient cohorts to strengthen their reliability. Ongoing research endeavors are essential to fully understand the benefits and limitations of this intervention in spinal cord injury rehabilitation.
Are work-related stress and positivity associated with health-related quality of life? Results of an observational study in a transport company in Italy
Authors: Manai Maria Vittoria , Colaprico Corrado , Ricci Eleonora , Fabbri Sabrina , Di Feo Graziano , Dorelli Barbara , Cocchiara Rosario Andrea , Faticoni Augusto , Sernia Sabina , De Sio Simone , La Torre Giuseppe 
Published: June 2024

Abstract
Aim
The job of a driver, particularly that of a public transportation driver, is a complex activity, requiring the mental and physical integrity of the operator. The presence of altered health status, fatigue related to prolonged driving, and all those conditions that interfere with the worker’s performance contribute to an increased risk of traffic accidents and occupational injuries. The aim of the study is to evaluate in an Italian transportation company how work-related stress and positivity affect the health-related quality of life of employees.

Subject and methods
A cross-sectional study was carried out from July 2019 to January 2020. Participants filled out a questionnaire divided into four sections (registry and socio-demographic, Karasek’s Job Content Questionnaire, Short Form 12 Survey, Positivity Scale) that aimed to gather information on work stress factors and health-related quality of life and positivity.

Results
Two hundred eight individuals responded to the questionnaire, including drivers and company staff. Significant differences were observed for the PCS dependent variable: in married participants (p = 0.026), in participants with children (p = 0.002) in the univariate analysis, and bivariate with the MCS variable (p = 0.001). Significant differences were observed for the MCS dependent variable only in the bivariate analysis: PCS (p = 0.001).

Conclusion
In this transport company, there was a high level of health-related work well-being in each of the activities carried out within it, since positivity was strongly associated with both physical and mental factors and given the homogeneity of the job demand and decision latitude.
Enhanced adaptive-convergence in Harris’ hawks optimization algorithm
Authors: Mao Mingxuan , Gui Diyu 
Published: June 2024

AbstractThis paper presents a novel enhanced adaptive-convergence in Harris’ hawks optimization algorithm (EAHHO). In EAHHO, considering that Harris’ hawks will adopt different perching strategies and chasing styles according to the value of the escaping energy parameter E, nonlinear adaptive-convergence factor a is designed and adjusted to enhance the convergence and robustness of the algorithm. Moreover, the convergence and stability of EAHHO are proved mathematically by using the Markov chain theory and Lyapunov stability theory respectively. Moreover, numerical simulation results of 14 HHOs with different nonlinear convergence factors on 23 benchmark functions show that the nonlinear convergence factor of EAHHO is applicable to challenging problems with unknown search spaces, and the comparisons with the selected well-established algorithms on 56 test functions demonstrate that EAHHO performs competitively and effectively. Finally, the experiment results show that EAHHO algorithm also has a good performance to solve the optimization problems with relatively high dimensions and graph size of Internet of Vehicles routing problem.
A vertical track nonlinear energy sink
Authors: Li Meng , Ding Hu 
Published: June 2024

AbstractEliminating the effects of gravity and designing nonlinear energy sinks (NESs) that suppress vibration in the vertical direction is a challenging task with numerous damping requirements. In this paper, the dynamic design of a vertical track nonlinear energy sink (VTNES) with zero linear stiffness in the vertical direction is proposed and realized for the first time. The motion differential equations of the VTNES coupled with a linear oscillator (LO) are established. With the strong nonlinearity considered of the VTNES, the steady-state response of the system is analyzed with the harmonic balance method (HBM), and the accuracy of the HBM is verified numerically. On this basis, the VTNES prototype is manufactured, and its nonlinear stiffness is identified. The damping effect and dynamic characteristics of the VTNES are studied theoretically and experimentally. The results show that the VTNES has better damping effects when strong modulation responses (SMRs) occur. Moreover, even for small-amplitude vibration, the VTNES also has a good vibration suppression effect. To sum up, in order to suppress the vertical vibration, an NES is designed and developed, which can suppress the vertical vibration within certain ranges of the resonance frequency and the vibration intensity.
Factors Associated with Prospective Acceptability and Preferences for Unified Transdiagnostic Cognitive-Behavioral Treatments and Group Therapy in the Portuguese General Population
Authors: Pedro Liliana Maria Rodrigues , de Oliveira Michael Fonseca , Pereira Marco Daniel , da Fonseca Ana Dias , Canavarro Maria Cristina 
Published: June 2024

AbstractGroup transdiagnostic cognitive-behavioral therapy (CBT) offers a promising solution for limited mental health access in Portugal. Understanding barriers to patient adherence is crucial for successful implementation. This study aimed to characterize the prospective acceptability and preferences for unified transdiagnostic CBT and group therapy in the Portuguese general population and explore their correlates. A sample of 243 participants (18–88 years old), recruited online, completed an online survey collecting information on sociodemographic and clinical characteristics, acceptability of transdiagnostic CBT treatments, specifically of Unified Protocol (UP), acceptability of group therapy, therapeutic format preferences, beliefs about group therapy and help-seeking attitudes. Most participants were receptive to and perceived as useful both unified transdiagnostic CBT and group therapy. Overall, participants presented significantly more favorable attitudes than unfavorable attitudes toward unified transdiagnostic CBT and group therapy (p < .001). Multivariate analyses revealed that (1) favorable attitudes toward transdiagnostic treatments were negatively associated with being employed and positively associated with living in an urban area, and higher efficacy scores; (2) unfavorable attitudes toward transdiagnostic treatments were positively associated with being married/cohabitating and negatively associated with vulnerability scores; (3) being female, living in an urban area, and higher efficacy and myth scores emerged as positive predictors of favorable attitudes toward group therapy; and (4) efficacy and vulnerability scores and help-seeking propensity emerged as negative predictors of unfavorable attitudes toward group therapy. These findings highlight the importance of delineating strategies to increase knowledge and acceptance of unified transdiagnostic CBT and group therapy in the Portuguese population, addressing specific individual characteristics.
On the effect of the sun on Kordylewski clouds
Authors: Gimeno Joan , Jorba Àngel , Jorba-Cuscó Marc , Nicolás Begoña 
Published: June 2024

AbstractIn this paper, we focus on the existence of dust clouds moving near the triangular points of the Earth–Moon system, the so-called Kordylewski clouds. The study is based on using some simplified planar models to find possible locations for these clouds. The validity of these predictions is tested by means of numerical simulations on a realistic model. The simplified models are based on the Earth–Moon restricted three-body problem plus the direct gravitational effect of the Sun on the particles (this is the so-called bicircular model), the solar radiation pressure and the Poynting–Robertson effect. The analysis of these models shows that there are some stability regions in the Earth–Moon plane, at some distance of the triangular points. The stability of these regions has been tested numerically in realistic (nonplanar) models. The results show that particles in these regions persist for some time (about a century), but it is very remarkable that many of these particles also escape the Earth–Moon system. If we perform backwards in time numerical simulations we obtain a similar result: particles also escape the Earth–Moon system after a similar time. From this point of view, the clouds are not a stable region in the classical sense of the term, but a region with “slow diffusion” where interplanetary particles stay for some years.
A first-in-human phase I trial of daily oral zelenirstat, a N-myristoyltransferase inhibitor, in patients with advanced solid tumors and relapsed/refractory B-cell lymphomas
Authors: Sangha Randeep , Jamal Rahima , Spratlin Jennifer , Kuruvilla John , Sehn Laurie H. , Beauchamp Erwan , Weickert Michael , Berthiaume Luc G. , Mackey John R. 
Published: June 2024

AbstractMyristoylation, the N-terminal addition of the fatty acid myristate to proteins, regulates membrane-bound signal transduction pathways important in cancer cell biology. This modification is catalyzed by two N-myristoyltransferases, NMT1 and NMT2. Zelenirstat is a first-in-class potent oral small molecule inhibitor of both NMT1 and NMT2 proteins. Patients with advanced solid tumors and relapsed/refractory (R/R) B-cell lymphomas were enrolled in an open label, phase I dose escalation trial of oral daily zelenirstat, administered in 28-day cycles until progression or unacceptable toxicity. The endpoints were to evaluate dose-limiting toxicities (DLT) to establish a maximum tolerated dose (MTD), pharmacokinetic parameters, and anticancer activity. Twenty-nine patients were enrolled (25 advanced solid tumor; 4 R/R B-cell lymphoma) and 24 were DLT-evaluable. Dosing ranged from 20 mg once daily (OD) to 210 mg OD without DLT, but gastrointestinal DLTS were seen in the 280 mg cohort. MTD and recommended phase 2 dose were 210 mg OD. Common adverse events were predominantly Gr ≤ 2 nausea, vomiting, diarrhea, and fatigue. Plasma concentrations peaked at 2 h with terminal half-lives averaging 10 h. Steady state was achieved by day 15, and higher doses achieved trough concentrations predicted to be therapeutic. Stable disease as best response was seen in eight (28%) patients. Progression-free survival and overall survival were significantly better in patients receiving 210 mg OD compared to those receiving lower doses. Zelenirstat is well-tolerated, achieves plasma exposures expected for efficacy, and shows early signs of anticancer activity. Further clinical development of zelenirstat is warranted.