bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preparation of ZTA composite ceramics derived from sol–gel method by DIW printing
Authors: Yang Xiaole , Guo Jinyu , Xie Hehan , Li Yuanbing , Yang Xianfeng 
Published: June 2024

AbstractIn this study, the dense and fine‐grained zirconia toughened alumina (ZTA) composite ceramics were efficiently prepared by 3D gel printing technology. Zirconia powder, zirconium oxychloride, and zirconium sol were introduced into boehmite gel as zirconium sources, and their effects on rheological properties, drying characteristics, microstructure, and mechanical properties of ceramics were discussed. The results showed that all gels exhibit reversible shear thinning properties. The gel with zirconia powder has a relaxation phenomenon; zirconium sol forms another gel network in the boehmite gel network, and two linear viscoelastic regions are observed. The gel with zirconia powder has the highest solid loading, small drying shrinkage, and fewer drying defects. The grain growth of ZTA ceramics with zirconium sol was inhibited, and the zirconia grains were evenly distributed, with the highest bending strength of 518 ± 103 MPa. The new gel preparation method and gel drying process offer great possibilities for manufacturing optical glasses and functional ceramics with high‐performance geometric structures, which cannot be achieved by traditional manufacturing methods.
Factors influencing work engagement of nurses in general hospitals: A cross‐sectional study
Authors: Maung May Zin Maung , Wichaikhum Orn‐Anong , Abhicharttibutra Kulwadee 
Published: June 2024

AbstractAimThis study aimed to examine the level of work engagement and to identify the factors influencing the work engagement of nurses.BackgroundWork engagement plays a crucial role in enhancing the efficiency of outcomes and the standard of care in nursing and healthcare services.MethodsA descriptive predictive design and stratified random sampling was used to select 206 nurses from three general hospitals in Naypyitaw, Myanmar.. Research instruments consisted of the demographic data form, the Utrecht Work Engagement Scale, the Global Transformational Leadership Scale, the Survey of Perceived Organizational Support, and the Psychological Capital Questionnaire. The results were explored by applying descriptive statistics and stepwise multiple regression.ResultsOverall work engagement was at an average level. Transformational leadership and psychological capital could affect work engagement, explaining 19.34% of the total variance; however, perceived organizational support, age, and work experience did not show any impact on it.ConclusionsThe findings recommend that nurse administrators should focus on transformational leadership and psychological capital in formulating strategies to increase nurses’ work engagement.Implications for nursing and health policyThe outcomes might provide baseline information for nurse administrators and policymakers by formulating management strategies to enhance nursing leaders’ awareness, knowledge, and skills about transformational leadership behaviors and to keep nurses holding self‐efficacy, hope, optimism, and resilience of psychological capital in healthcare organizations, which ultimately increase nurses’ engagement at work.
Robust species distribution predictions of predator and prey responses to climate change
Authors: Ge Xuezhen , Griswold Cortland K. , Newman Jonathan A. 
Published: June 2024

AbstractAimSpecies distribution models (SDMs) can be correlative or mechanistic, which have very different assumptions, leading to potentially different estimates of the ecological niches and distributions of the species. The model predictions from correlative and mechanistic approaches are incomparable due to their distinct assumptions. Yet, seeking their agreements can identify robust predictions that are relatively independent of the assumptions used to generate them. However, the search for robust model predictions among SDM models remains understudied and rarely considers the effect of biotic interactions. It is essential to identify robust predictions from SDMs for policy making.LocationGlobal.Time Period1970–2000/1980–2000 and 2081–2100.Major Taxa StudiesAphids.MethodsIn this study, we selected five aphid species as examples, and applied an ensemble model of multiple correlative SDMs (eC‐SDM), a mechanistic SDM of the prey species alone (M‐SDM) and a mechanistic SDM of the predator–prey interactions (M‐BI‐SDM), to predict the habitat suitability of these aphids under climate change and seek robust predictions from both approaches, as well as evaluate the importance of biotic interactions in SDM studies.ResultsOur results show that the five aphid species have different habitat suitability patterns predicted by both correlative and mechanistic approaches. However, there is a notable consensus between the model predictions for parts of North America and eastern Asia, indicating that the predictions in these regions are robust. Additionally, our mechanistic models allow us to assess the importance of predation on SDM predictions, revealing that predation can quantitatively affect species' habitat suitability both directly and indirectly.Main ConclusionsOur study suggests that mechanistic SDM could serve as a valuable addition to assess the robustness of the correlative SDM predictions, by providing additional biological realism. It highlights the importance of using diverse modelling approaches to achieve robust model predictions.
Shenqi Fuzheng injection facilitates skeletal muscle mitophagy mediated by the ubiquitination of HIF‐1α to ameliorate cancer‐associated fatigue
Authors: Guo Wei , Liu Shan , Xia Huan , Luo Jiamin , Chen Hanrui , Hu Leihao , Zheng Xinting , Xiao Zhiwei , Lin Lizhu 
Published: June 2024

AbstractCancer‐related fatigue (CRF) significantly impacts the quality of life of cancer patients. This study investigates the therapeutic potential of Shenqi Fuzheng injection (SFI) in managing CRF, focusing on its mechanistic action in skeletal muscle. We utilized a CRF mouse model to examine the effects of SFI on physical endurance, monitoring activity levels, swimming times and rest periods. Proteomic analysis of the gastrocnemius muscle was performed using isobaric tags and liquid chromatography–tandem mass spectrometry to map the muscle proteome changes post‐SFI treatment. Mitochondrial function in skeletal muscle was assessed via ATP bioluminescence assay. Furthermore, the regulatory role of the hypoxia inducible factor 1 subunit alpha (HIF‐1α) signalling pathway in mediating SFI's effects was explored through western blotting. In CRF‐induced C2C12 myoblasts, we evaluated cell viability (CCK‐8 assay), apoptosis (flow cytometry) and mitophagy (electron microscopy). The study also employed pulldown, luciferase and chromatin immunoprecipitation assays to elucidate the molecular mechanisms underlying SFI's action, particularly focusing on the transcriptional regulation of PINK1 through HIF‐1α binding at the PINK1 promoter region. Our findings reveal that SFI enhances physical mobility, reduces fatigue symptoms and exerts protective effects on skeletal muscles by mitigating mitochondrial damage and augmenting antioxidative responses. SFI promotes cell viability and induces mitophagy while decreasing apoptosis, primarily through the modulation of HIF‐1α, PINK1 and p62 proteins. These results underscore SFI's efficacy in enhancing mitochondrial autophagy, thereby offering a promising approach for ameliorating CRF. The study not only provides insight into SFI's potential therapeutic mechanisms but also establishes a foundation for further exploration of SFI interventions in CRF management.
Study of the mechanism by which Xiaoyan decoction combined with E7449 regulates tumorigenesis in lung adenocarcinoma
Authors: Zheng Xu , Han Yanyan , Gu Lili , Gao Shan , Lv Yan , Li Chong 
Published: June 2024

AbstractTNKS is a new target for the treatment of lung adenocarcinoma, the synergistic effects of the TCM compound Xiaoyan decoction and the TNKS inhibitor E7449 in the intervention on TNKS were investigated, and the possible underlying mechanisms involved were clarified. Immunohistochemistry was used to analyse TNKS expression in tumour tissues. The impact of targeting TNKS on cell growth, invasion, apoptosis, key genes and signalling pathways was investigated in tumour cells by Western blotting, rescue experiments, colony formation assays, flow cytometry and label‐free experiments. Tumour xenografts with A549 cells were then transplanted for in vivo study. We found that TNKS high expression was closely related to the advanced tumour stage and tumour size in lung adenocarcinom. After TNKS was knocked down in vitro, the growth, proliferation, migration and invasion were markedly reduced in A549 and H1975 cells. We subsequently applied the Xiaoyan decoction and TNKS inhibitors to intervene in lung adenocarcinoma. Xiaoyan decoction and E7449 suppressed TNKS expression and inhibited adenocarcinoma cell proliferation, migration, invasion and apoptosis in vitro. Proteomic analysis revealed that E7449 treatment may be most closely associated with the classic Wnt/β‐catenin pathway, whereas Xiaoyan decoction treatment may be related to the WNT/PLAN pathway. Xenograft studies confirmed that E7449 or Xiaoyan decoction inhibited lung tumour growth in vivo and attenuated the Wnt signalling pathway in adenocarcinoma. These findings suggest that TNKS is a novel therapeutic target. TCM preparations and small molecule inhibitors are expected to constitute an effective combination strategy.
Autophagy is the main driver of radioresistance of HNSCC cells in mild hypoxia
Authors: Hill Rhianna M. , Li Chun , Hughes Jonathan R. , Rocha Sonia , Grundy Gabrielle J. , Parsons Jason L. 
Published: June 2024

AbstractHypoxia poses a significant challenge to the effectiveness of radiotherapy in head and neck squamous cell carcinoma (HNSCC) patients, and it is imperative to discover novel approaches to overcome this. In this study, we investigated the underlying mechanisms contributing to x‐ray radioresistance in HPV‐negative HNSCC cells under mild hypoxic conditions (1% oxygen) and explored the potential for autophagy modulation as a promising therapeutic strategy. Our findings show that HNSCC cells exposed to mild hypoxic conditions exhibit increased radioresistance, which is largely mediated by the hypoxia‐inducible factor (HIF) pathway. We demonstrate that siRNA knockdown of HIF‐1α and HIF‐1β leads to increased radiosensitivity in HNSCC cells under hypoxia. Hypoxia‐induced radioresistance was not attributed to differences in DNA double strand break repair kinetics, as these remain largely unchanged under normoxic and hypoxic conditions. Rather, we identify autophagy as a critical protective mechanism in HNSCC cells following irradiation under mild hypoxia conditions. Targeting key autophagy genes, such as BECLIN1 and BNIP3/3L, using siRNA sensitizes these cells to irradiation. Whilst autophagy's role in hypoxic radioresistance remains controversial, this study highlights the importance of autophagy modulation as a potential therapeutic approach to enhance the effectiveness of radiotherapy in HNSCC.
Senescence induces miR‐409 to down‐regulate CCL5 and impairs angiogenesis in endothelial progenitor cells
Authors: Chou Yen‐Hung , Lee Yi‐Nan , Su Cheng‐Huang , Lee Hsin‐I , Hsieh Chin‐Ling , Tien Ting‐Yi , Lin Chao‐Feng , Yeh Hung‐I , Wu Yih‐Jer 
Published: June 2024

AbstractThis study explores the impact of senescence on autocrine C‐C motif chemokine ligand 5 (CCL5) in human endothelial progenitor cell (EPCs), addressing the poorly understood decline in number and function of EPCs during ageing. We examined the effects of replication‐induced senescence on CCL5/CCL5 receptor (CCR5) signalling and angiogenic activity of EPCs in vitro and in vivo. We also explored microRNAs controlling CCL5 secretion in senescent EPCs, its impact on EPC angiogenic activity, and validated our findings in humans. CCL5 secretion and CCR5 levels in senescent EPCs were reduced, leading to attenuated angiogenic activity. CCL5 enhanced EPC proliferation via the CCR5/AKT/P70S6K axis and increased vascular endothelial growth factor (VEGF) secretion. Up‐regulation of miR‐409 in senescent EPCs resulted in decreased CCL5 secretion, inhibiting the angiogenic activity, though these negative effects were counteracted by the addition of CCL5 and VEGF. In a mouse hind limb ischemia model, CCL5 improved the angiogenic activity of senescent EPCs. Analysis involving 62 healthy donors revealed a negative association between CCL5 levels, age and Framingham Risk Score. These findings propose CCL5 as a potential biomarker for detection of EPC senescence and cardiovascular risk assessment, suggesting its therapeutic potential for age‐related cardiovascular disorders.
Reassessing the impact of health IT: Hidden costs and consequences of vendor heterogeneity
Authors: Lin Jianjing , Olson Mary K. 
Published: June 2024

AbstractThe government has invested more than $24.8 billion to incentivize the adoption of health information technology in hospitals; however, there is little evidence showing that these investments produced the expected efficiencies, such as cost savings and improved quality of care. We examine whether vendor heterogeneity can help explain this puzzle. Our results show that the effects of electronic medical record (EMR) adoption on hospital costs and quality vary substantially by vendor. Only certain EMR vendors lead to cost savings (ranging between 3.1% and 4.7%) or quality of care improvements (lowering rates of adverse drug events from 0.38 to 1.68 percentage points) for adopting hospitals, while the adoption of other EMR vendors leads to either cost increases, quality of care reductions, or no significant effects. Our results suggest that both quality improvement and cost savings may be improved by a more strategic choice of vendor. The variability in EMR effectiveness by vendor also implies that there was a hidden cost of the government's program to incentivize the adoption of EMRs in hospitals.
Half Banked: The Economic Impact of Cash Management in the Marijuana Industry
Authors: BERGER ELIZABETH A. , SEEGERT NATHAN 
Published: June 2024

ABSTRACTWe investigate the economic value of cash management. In the legal marijuana industry, where only half of businesses have access to cash management services from a financial institution, we examine dispensary profitability using administrative and survey data. Our results show that businesses with cash management charge higher retail prices (8.3%), pay lower wholesale prices (7.3%), and have higher sales volume (19%). Together, these advantages create a 40% increase in profitability. These results support our model in which reputational capital and administrative costs drive profitability regardless of whether national banks, credit unions, or fintech provide the cash management functions.
Receiving screened donor human milk as part of a community‐based lactation support programme reduces parental symptoms of anxiety and depression
Authors: Brown Amy , Griffin Sam , Weaver Gillian , Shenker Natalie 
Published: June 2024

AbstractInfant feeding decisions and maternal mental health are closely tied. Donor human milk (DHM) protects premature infant health and development and can reduce hospital stays. Recent qualitative research has highlighted that having the option for an infant to receive DHM can also support parental wellbeing through reducing concerns about infant health and supporting feeding preferences. However, no quantitative study has examined this relationship. In this study, anxiety and depression scores were measured before and after receiving DHM using the Hospital Anxiety and Depression Scale for 80 parents (77 mothers, 3 fathers) who had sought DHM from a community‐facing milk bank. Reasons for seeking DHM included maternal cancer, maternal and infant health complications, insufficient glandular tissue, and low milk supply. Open‐ended questions explored the experience of receiving milk. Milk bank records were used to match details of milk given (volume, duration, exclusivity, lactation support given) with survey responses. Both anxiety and depression scores significantly reduced after receiving milk. Although greater lactation support and longer duration of milk predicted a greater decrease in scores, in a regression analysis, only volume of milk given remained a significant predictor. Almost all parents agreed that being able to access DHM supported their wellbeing predominantly through reducing anxieties around infant health but also through feeding choices being respected and the support given at difficult times. The findings add important considerations to the literature considering when and for whom DHM should be used and the complex interplay between infant feeding and mental health.
Modeling of spatially embedded networks via regional spatial graph convolutional networks
Authors: Fan Xudong , Hackl Jürgen 
Published: June 2024

AbstractEfficient representation of complex infrastructure systems is crucial for system‐level management tasks, such as edge prediction, component classification, and decision‐making. However, the complex interactions between the infrastructure systems and their spatial environments increased the complexity of network representation learning. This study introduces a novel geometric‐based multimodal deep learning model for spatially embedded network representation learning, namely the regional spatial graph convolutional network (RSGCN). The developed RSGCN model simultaneously learns from the node's multimodal spatial features. To evaluate the network representation performance, the introduced RSGCN model is used to embed different infrastructure networks into latent spaces and then reconstruct the networks. A synthetic network dataset, a California Highway Network, and a New Jersey Power Network were used as testbeds. The performance of the developed model is compared with two other state‐of‐the‐art geometric deep learning models, GraphSAGE and Spatial Graph Convolutional Network. The results demonstrate the importance of considering regional information and the effectiveness of using novel graph convolutional neural networks for a more accurate representation of complex infrastructure systems.
Classification and Treatment Strategies of Tibial Tubercle Fractures in Adults
Authors: Yao Xiang , Liu Hongyuan , Ma Yuxuan , Hu Minjie , Wang Chong , Miao Han , Liu ShengJie , Tang Jilei 
Published: June 2024

ObjectivesTibial tubercle is a crucial player in maintaining the structural integrity and functional stability of the knee joint. Currently, there is no standardized protocol for the classification and treatment of tibial tubercle fractures in adults. This study analyzed the incidence and treatment strategies of tibial tubercle fractures in adults according to the four‐column and nine‐segment classification system.MethodsData of patients with proximal tibial fractures involving tibial tubercle fractures who were treated at our hospital from August 2007 to March 2023 were retrospectively reviewed. The fractures were classified using the AO/OTA classification and four‐column and nine‐segment classification systems, and the treatment protocol (surgically treated or conservatively treated) was recorded. The number and distribution proportion of patients were counted. A two‐sided t‐test was conducted to determine the significance of differences between the gender and sides.ResultsIn total, 169 tibial tubercle fractures were found in 1484 proximal tibial fractures. According to the AO/OTA classification, seven of the 169 patients, (4.1%) were type A, 36 patients (21.3%) were type B, and 126 patients (74.6%) were type C. According to the four‐column and nine‐segment classification, type 1 cleavage without free fragments was the most common type of fracture (93/169, 55.0%), followed by type 2 dissociative segmental fragments (48/169, 28.4%) and type 3 comminuted fractures (28/169, 16.6%). Overall, 139 of the 169 proximal tibial fractures with tuberosity involvement were treated surgically. Among them, additional fixation of the tubercle fragment was performed in 52 fractures.ConclusionThe incidence of tibial tubercle fractures involved in proximal tibial fractures was approximately 11.4% (169/1484) in adults, and approximately one‐third of the tubercle bone fragment required additional fixation (30.8%, 52/169). The injury types in the four‐column and nine‐segment classifications are helpful for accurately judging and making treatment‐related decisions for tibial tubercle fractures.
The Demands of the Disabled: Masculinity, Disability, and Citizenship in the Late Imperial Russian Military
Authors: Hearne Siobhán 
Published: June 2024

AbstractIn the years after 1905, catastrophic war, widespread political and social unrest, and rising demands from across all segments of the empire’s population forced the Russian imperial state to develop a rudimentary social contract with military personnel and implement a series of reforms to prevent the reoccurrence of military disaster and mass social unrest. These reforms entitled disabled veterans to some forms of state support that were denied to their civilian counterparts, including assistance finding work, pensions, and free prosthetic devices. These entitlements were part of a broader shift away from paternalistic approaches to social welfare provision toward the early germinations of a gendered and selective welfare state. Disability support was dependent on proximity to the military, which cemented the idea that civic inclusion—and by extension, Russian manhood—was something achieved only through military service. This article examines interactions between veterans with disabilities and representatives of the Russian imperial state to explore shifting conceptions of masculinity and the development of new political subjectivities in the aftermath of war. The Russian imperial military can be regarded as a test site within which masculine identities were negotiated and reconfigured amid the social, economic, and political transformations of the late imperial period.
A conversation with Nils Lid Hjort
Authors: Borgan Ørnulf , Glad Ingrid K. 
Published: June 2024

AbstractProfessor (now emeritus) Nils Lid Hjort has through more than four decades been one of the most original and productive statisticians in Norway, contributing to a wide range of topics such as survival analysis, Bayesian nonparametrics, empirical likelihood, density estimation, focused inference, model selection, and confidence distributions. This conversation, which took place at the University of Oslo in December 2023, sheds light on how Nils Hjort's curious and open mind, coupled with a deep understanding, has enabled him to seamlessly navigate between different fields of statistics and its applications. Our aim is to encourage the statistics community to always be on the lookout for unexpected connections in statistical science and to embrace unexpected encounters with fellow statisticians from around the world.