bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wildfire smoke impacts lake ecosystems
Authors: Farruggia Mary Jade , Brahney Janice , Tanentzap Andrew J. , Brentrup Jennifer A. , Brighenti Ludmila S. , Chandra Sudeep , Cortés Alicia , Fernandez Rocio L. , Fischer Janet M. , Forrest Alexander L. , Jin Yufang , Larrieu Kenneth , McCullough Ian M. , Oleksy Isabella A. , Pilla Rachel M. , Rusak James A. , Scordo Facundo , Smits Adrianne P. , Symons Celia C. , Tang Minmeng , Woodman Samuel G. , Sadro Steven 
Published: June 2024

AbstractWildfire activity is increasing globally. The resulting smoke plumes can travel hundreds to thousands of kilometers, reflecting or scattering sunlight and depositing particles within ecosystems. Several key physical, chemical, and biological processes in lakes are controlled by factors affected by smoke. The spatial and temporal scales of lake exposure to smoke are extensive and under‐recognized. We introduce the concept of the lake smoke‐day, or the number of days any given lake is exposed to smoke in any given fire season, and quantify the total lake smoke‐day exposure in North America from 2019 to 2021. Because smoke can be transported at continental to intercontinental scales, even regions that may not typically experience direct burning of landscapes by wildfire are at risk of smoke exposure. We found that 99.3% of North America was covered by smoke, affecting a total of 1,333,687 lakes ≥10 ha. An incredible 98.9% of lakes experienced at least 10 smoke‐days a year, with 89.6% of lakes receiving over 30 lake smoke‐days, and lakes in some regions experiencing up to 4 months of cumulative smoke‐days. Herein we review the mechanisms through which smoke and ash can affect lakes by altering the amount and spectral composition of incoming solar radiation and depositing carbon, nutrients, or toxic compounds that could alter chemical conditions and impact biota. We develop a conceptual framework that synthesizes known and theoretical impacts of smoke on lakes to guide future research. Finally, we identify emerging research priorities that can help us better understand how lakes will be affected by smoke as wildfire activity increases due to climate change and other anthropogenic activities.
Geographic barriers but not life history traits shape the phylogeography of North American mammals
Authors: Jensen Alex J. , Cove Michael V. , Goldstein Benjamin R. , Kays Roland , McShea William , Pacifici Krishna , Rooney Brigit , Kierepka Elizabeth 
Published: June 2024

AbstractAimSynthesize literature on genetic structure within species to understand how geographic features and species traits influence past responses to climate change.LocationNorth America.Time PeriodWe synthesized phylogeographic studies from 1978 to 2023, which describe genetic lineages that diverged during the Pleistocene (≥11,700 years ago).Major Taxa StudiedMammals.MethodsWe conducted a literature review to map genetic breaks in species distributions, then tested a set of geographic hypotheses (e.g., mountains, rivers) to explain their position by comparing break locations to a grid within each species' sampled range using logistic regression. We then conducted a meta‐analysis using species‐specific model estimates to ask if life‐history traits explained variation in which barriers were most important in species' past response to climate change.ResultsOur findings reveal heterogeneity in both where North American mammal phylogeography has been studied and the density of genetic breaks across 229 species. We found relatively high concordance among carnivores, ungulates and lagomorphs, where breaks were associated with mountains, major water bodies and relatively even terrain. In contrast, we found high variability within rodents and shrews, and no evidence that intrinsic factors related to dispersal ability explained the importance of hypothesized barriers across all species.Main ConclusionsSouthern Mexico is a hotspot for genetic breaks that has yet to be integrated into the broader story of North American phylogeography. We show that mountains and major water bodies play particularly important roles as barriers, but substantial variation across species within orders suggests that there is more to the story besides shared climatic or phylogenetic histories. Thus, understanding the phylogeography of individual species will continue to be important given that our results suggest high variability in how species may respond to future global change.
Variant‐specific BCR::ABL1 quantification discrepancy in chronic myeloid leukemia
Authors: Jacobs Koen , Moerman Alena , Vandepoele Karl , Abeele Tim Van den , De Mulder Katrien , Steel Eva , Clauwaert Maxim , Louagie Henk 
Published: June 2024

AbstractIntroductionAccurate quantification of the BCR::ABL1 fusion gene in whole blood is pivotal for the clinical management of chronic myeloid leukemia (CML) patients. The fusion protein encoded by BCR::ABL1 can vary in size, depending on the BCR and/or ABL1 gene breakpoint. The vast majority of CML patients have a p210 BCR::ABL1 fusion gene (M‐BCR), which can be attributed to the presence of either e14a2 (b3a2) or e13a2 (b2a2) mRNA transcript junctions.MethodsTwenty‐five CML samples were analyzed in two different ISO15189‐accredited centers that both use an Europe Against Cancer‐based quantitative polymerase chain reaction (qPCR) protocol. Reanalysis of the sample set with transcript‐specific standard curves and digital droplet PCR (ddPCR) were performed.ResultsqPCR quantification revealed a significant (up to 1 log) difference specifically for the e13a2 transcript variant in contrast to e14a2 transcripts (Hodges–Lehman 4.29; p < 0.001). Reanalysis of the sample set with transcript‐specific standard curves abolishes the initial transcript‐specific difference (Hodges–Lehman 0.003; p = 0.8192). Comparison of transcript‐specific qPCR results of both centers with ddPCR, an absolute quantification method, showed a statically significant association, especially in the lower range, indicating the clinical utility of transcript‐specific or absolute quantification methods.ConclusionOur data show that differences between transcript‐specific quantification might exist between centers, leading to potential clinical impact on the follow‐up of CML patients. The use of transcript‐specific standard curves for qPCR quantification, or absolute quantification, can significantly reduce these differences. Specific attention should be applied to the interpretation of quantification differences of CML patients that switch between diagnostic centers.
Nirsevimab Effectiveness Against Cases of Respiratory Syncytial Virus Bronchiolitis Hospitalised in Paediatric Intensive Care Units in France, September 2023–January 2024
Authors: Paireau Juliette , Durand Cécile , Raimbault Sylvain , Cazaubon Joséphine , Mortamet Guillaume , Viriot Delphine , Milesi Christophe , Daudens‐Vaysse Elise , Ploin Dominique , Tessier Sabrina , Vanel Noémie , Chappert Jean‐Loup , Levieux Karine , Ollivier Ronan , Daoudi Jamel , Coignard Bruno , Leteurtre Stéphane , Parent‐du‐Châtelet Isabelle , Vaux Sophie 
Published: June 2024

ABSTRACTIn September 2023, France was one of the first countries that started a national immunisation campaign with nirsevimab, a new monoclonal antibody against respiratory syncytial virus (RSV). Using data from a network of paediatric intensive care units (PICUs), we aimed to estimate nirsevimab effectiveness against severe cases of RSV bronchiolitis in France. We conducted a case–control study based on the test‐negative design and included 288 infants reported by 20 PICUs. We estimated nirsevimab effectiveness at 75.9% (48.5–88.7) in the main analysis and 80.6% (61.6–90.3) and 80.4% (61.7–89.9) in two sensitivity analyses. These real‐world estimates confirmed the efficacy observed in clinical studies.
Mohs micrographic surgery for the treatment of invasive melanoma: A systematic review with meta‐analyses
Authors: Williams G. J. , Quinn T. , Lo S. , Guitera P. , Scolyer R. A. , Thompson J. F. , Ch'ng S. 
Published: June 2024

AbstractBackgroundThe use of Mohs micrographic surgery (MMS) in melanoma treatment has divided opinion and evidence‐based guidelines are lacking.ObjectivesThis systematic review aimed to analyse clinical outcomes for patients with invasive melanomas treated with Mohs rather than wide local excision (WLE).MethodsEmbase, MEDLINE and Cochrane databases (to 30 August 2023) were searched for studies using Mohs to treat invasive melanoma. Outcomes of interest were local recurrence and death from melanoma.ResultsThirty‐five articles involving 41,499 patients with invasive melanoma treated with Mohs were identified. Sixteen studies compared Mohs with WLE and 19 were Mohs‐only, non‐comparative studies. Patients treated with Mohs differed significantly from those undergoing WLE, in particular Mohs patients were older and had thinner melanomas. Two comparative studies using the same data source reported adjusted hazard ratios for melanoma‐specific death and both showed no significant difference between Mohs and WLE‐treated patients; 0.87 (95% CI 0.55–1.35) and 1.20 (95% CI 0.71–20.36). There was also no statistically significant difference in local recurrence risk; the unadjusted risk ratio for patients treated with Mohs was 0.46 (95% CI 0.14–1.51 p = 0.20) with moderate heterogeneity (I2 = 62%). No studies reported multivariable analyses for risk of local recurrence. Many studies generated from relatively few and often overlapping data sets have reported the use of Mohs to treat patients with invasive melanoma. Fewer studies were comparative between Mohs and WLE and these reported substantially different baseline risks of recurrence and death from melanoma between the groups. Mohs has generally been used for thinner melanomas in older patients; therefore, comparisons based on univariable analyses are likely to have been misleading.ConclusionsOn the basis of currently available data, it is not possible to reliably assess whether outcomes differ if invasive melanomas with comparable features are treated with Mohs or WLE, and randomized trial evidence will be required for reliable conclusions to be reached.
A symbolic interactionist model of White adolescents' digital critical racial literacy and digital anti‐racist action
Authors: Klein Sydney , Csizmadia Annamaria , Adamsons Kari 
Published: June 2024

AbstractSymbolic interactionism is useful for examining how various socialization contexts (e.g., family and media) inform adolescents' identity construction and role making. Some research supports the theory's application in understanding White adolescents' racial socialization and identity development. The theory has yet to be applied to understanding the critical components that are essential for understanding how individuals interact with a digital society where racial inequality is pervasive. We propose a model of White adolescents' racial identity in response to racial socialization, and how that relationship manifests in social media contexts. We discuss how racial and social media literacies interact with family socialization and identity‐related experiences to promote White adolescents' critical race consciousness and introduce a novel application of digital critical racial literacy and digital anti‐racist action. The model advances symbolic interactionism by incorporating a critical lens, and can inform interventions aimed to educate parents, White youth, and social‐media developers on anti‐racist development.
Prophylactic use of a self‐assembling peptide hydrogel for preventing delayed bleeding after endoscopic sphincterotomy: A propensity score‐matched analysis
Authors: Inoue Tadahisa , Kitano Rena , Ibusuki Mayu , Sakamoto Kazumasa , Kimoto Satoshi , Arai Jun , Nakade Yukiomi , Ito Kiyoaki 
Published: June 2024

AbstractBackground and AimDelayed endoscopic sphincterotomy‐related bleeding (ES bleeding) is an unavoidable adverse event (AE) that can have serious ramifications. Intraoperative ES bleeding, which stops spontaneously in most cases, is a known risk factor for delayed bleeding. This study aimed to examine the preventive effect of a novel self‐assembling peptide (SAP) for delayed ES bleeding in patients who attained spontaneous hemostasis after intraoperative ES bleeding.MethodsA total of 1507 patients met the eligibility criteria for inclusion in this study. The rates of delayed ES bleeding and AE besides bleeding were compared between patients administered the SAP (SAP group) and those who were simply observed after spontaneous hemostasis of intraoperative ES bleeding (control group). Propensity score matching was performed to adjust for differences between the groups.ResultsThe rate of delayed ES bleeding was significantly lower in the SAP group than that in the control group (0.9% vs 3.8%, P = 0.044). The rates of AEs other than bleeding were 2.4% and 3.8% in the SAP and control groups, respectively, and the difference lacked statistical significance (P = 0.481). Multivariate analysis revealed that the use of SAP was significantly associated with a lower frequency of delayed ES bleeding (odds ratio, 0.35; 95% confidence interval, 0.13–0.98; P = 0.047).ConclusionsSelf‐assembling peptide may be a simple, safe, and useful way to reduce the risk of delayed ES bleeding in patients who experienced intraoperative ES bleeding and obtained subsequent spontaneous hemostasis.
Differences in RAD51 transcriptional response and cell cycle dynamics reveal varying sensitivity to DNA damage among Arabidopsis thaliana root cell types
Authors: Kutashev Konstantin , Meschichi Anis , Reeck Svenja , Fonseca Alejandro , Sartori Kevin , White Charles I. , Sicard Adrien , Rosa Stefanie 
Published: June 2024

Summary

Throughout their lifecycle, plants are subjected to DNA damage from various sources, both environmental and endogenous. Investigating the mechanisms of the DNA damage response (DDR) is essential to unravel how plants adapt to the changing environment, which can induce varying amounts of DNA damage.

Using a combination of whole‐mount single‐molecule RNA fluorescence in situ hybridization (WM‐smFISH) and plant cell cycle reporter lines, we investigated the transcriptional activation of a key homologous recombination (HR) gene, RAD51, in response to increasing amounts of DNA damage in Arabidopsis thaliana roots.

The results uncover consistent variations in RAD51 transcriptional response and cell cycle arrest among distinct cell types and developmental zones. Furthermore, we demonstrate that DNA damage induced by genotoxic stress results in RAD51 transcription throughout the whole cell cycle, dissociating its traditional link with S/G2 phases.

This work advances the current comprehension of DNA damage response in plants by demonstrating quantitative differences in DDR activation. In addition, it reveals new associations with the cell cycle and cell types, providing crucial insights for further studies of the broader response mechanisms in plants.
Plant growth promoting rhizobacteria (PGPR) application for coping with salinity and drought: a bibliometric network multi‐analysis
Authors: Lorenz C. , Vitale E. , Hay‐Mele B. , Arena C. 
Published: June 2024

Abstract

Rhizobacteria play a crucial role in plant growth and yield, stimulating primary production and improving stress resistance. Climate change has several consequences worldwide that affect arable land and agriculture. Studies on plant–soil–microorganism interactions to enhance plant productivity and/or resistance to abiotic stress may open new perspectives. This strategy aims to make agricultural‐relevant plant species able to complete their biological cycle in extreme soils with the help of inoculated or primed plant growth‐promoting rhizobacteria (PGPR).

We provide an overview of the evolution of interest in PGPR research in the last 30 years through: (i) a quantitative search on the Scopus database; (ii) keyword frequencies and clustering analysis, and (iii) a keyword network and time‐gradient analysis.

The review of scientific literature on PGPR highlighted an increase in publications in the last 15 years, and a specific time gradient on subtopics, such as abiotic stresses. The rise in PGPR as a keyword co‐occurring with salinity and drought stresses aligns with the growing number of papers from countries directly or partly affected by climate change.

The study of PGPR, its features, and related applications will be a key challenge in the next decades, considering climate change effects on agriculture. The increased interest in PGPR leads to deeper knowledge focused specifically on researching agriculturally sustainable solutions for soils affected by salinity and drought.
Trilemma versus dilemma: Monetary autonomy and long‐term interest rate independence
Authors: Kim Kyunghun , Kim Soyoung 
Published: June 2024

AbstractThis study investigates the issue of trilemma versus dilemma in relation to monetary autonomy. We construct a long‐term interest rate independence index (LRI) apart from the conventional monetary policy independence evaluated on the basis of the short‐term interest rate independence index (SRI). LRI intends to capture the independence of domestic financial conditions and the monetary policy in a broad sense. Empirical results are as follows. On the basis of SRI, trilemma holds well, in which trade‐offs between SRI and international capital mobility and between SRI and exchange rate stability are found. This outcome is consistent with the findings of many past studies that support trilemma. However, on the basis of LRI, dilemma holds after the global financial crisis because only the trade‐off between LRI and international capital mobility exists. This result is consistent with the conclusion of Rey (2013), which emphasized the huge effects of the global financial cycle on the domestic financial condition owing to the integration of international financial markets. Empirical results settle the issue between trilemma and dilemma.
Dimensional model of socioemotional learning built on a large‐scale sample of Chilean students
Authors: Berger Christian , Angulo Gallo Lisandra 
Published: June 2024

AbstractEven though Social and Emotional Learning (SEL) has become a central domain in education, there is still a lack of clarity in the underlying conceptual models guiding educational efforts and insufficient empirical evidence supporting these models. The Chilean Agency for Quality in Education developed a socioemotional questionnaire as part of the Comprehensive Learning Diagnosis (DIA), administered in educational institutions nationwide. Its underlying conceptual model considers nine SEL competencies structured into three dimensions: Individual, Communal, and Civic, mapping onto the Chilean educational curriculum and learning goals relative to SEL. Even though this model was built based on a thorough revision of existing approaches to SEL and assessment tools, this dimensional structure has not been empirically tested. This study explores a dimensional model of SEL based on a large‐scale sample of Chilean students assessed through the DIA (882,553 7th–12th graders). Exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) were conducted to determine the dimensional structure, also testing for invariance by educational level (basic vs. secondary education) and gender. EFA evidenced a three‐dimensional structure, with factors labeled as individual, relational, and socio‐moral based on their composition. CFA confirmed these dimensions with adequate fit indices. Factorial invariance of the identified model was found between basic and secondary school students, and between boys and girls. The study allowed for the construction of a theoretical model of SEL based on a large‐scale sample. The identification of a moral factor as a key dimension of SEL constitutes a novel and promising perspective, in line with recent research providing new insights into SEL. Further evidence regarding the reliability and validity of the instrument should be analyzed. Also, the proposed SEL model should be tested in different countries and populations to broaden our understanding of SEL and inform educational policies and practices.
Clause Typing in Main Polar Questions: Evidence from Italo‐Romance
Authors: Munaro Nicola 
Published: June 2024

AbstractThis article investigates the morpho‐syntactic marking of main polar questions, which is achieved across Italo‐Romance by crosslinguistically different strategies. I argue that the interpretation of main polar questions is related to the activation of a dedicated functional head that encodes the relevant formal feature within the left‐periphery. In particular, I explore the possibility that the process of clause typing in unembedded yes/no questions is linked in Italo‐Romance to the activation of a functional projection located in the right periphery of the CP‐layer, which I call Polarity Phrase. This hypothesis relies on the intuition that negation and affirmation can be reduced to a more abstract category encoding the open polarity of the sentence, which can be underspecified for either negative or positive value.
Comparison of selected cytomorphological features of canine pemphigus foliaceus and superficial pyoderma
Authors: Spriggs Tyler S. , Gedon Natalie K. Y. , Linder Keith E. , Bizikova Petra 
Published: June 2024

AbstractBackgroundCytological detection of acantholytic keratinocytes (acantholytic cells [AC]) helps to identify canine pemphigus foliaceus (cPF) yet AC also occurs in superficial pyoderma (SP), the main differential diagnosis.Hypothesis/ObjectivesTo compare selected cytomorphological features of cPF and SP and to establish cytological diagnostic criteria that could differentiate cPF from SP.Animals40 and 51 client‐owned dogs with PF and SP, respectively.Materials and MethodsImpression smears from cPF (64), impetigo (40) and exfoliative superficial pyoderma (ESP) (17) samples were stained with Romanowsky stain, randomised, blinded and evaluated by two investigators independently. The entire sample was screened (×500 or ×1000 magnification) for round (AC1), boat (AC2) and raft AC, eosinophils and bacteria. Interobserver agreements were calculated.ResultsThe average number of the 10 highest ×500 fields for AC1 and AC2 was significantly higher in PF than SP (p < 0.0001; Kruskal–Wallis test). Rafts and eosinophils were more common in PF than SP (p < 0.0001; chi‐square test), while bacteria were rare in PF (5%; p < 0.0001; chi‐square test). Observations between the experienced and novice investigators were highly correlated. An ROC analysis identified five AC1/×500‐magnification field as a suitable cut‐off value for predicting PF diagnosis. This cut‐off value was tested by two additional investigators, who identified sensitivity of 84%–100%, specificity of 95%–97% and accuracy of 95%–96% for the diagnosis of cPF.Conclusions and Clinical RelevanceCriterion‐based impression smear cytological evaluation can provide strong evidence to support the clinical diagnosis. Acantholytic cell morphology varies in cPF and SP, and experience can improve accuracy in cytological differentiation.