bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exercise parameters in the management of breast cancer: A systematic review of randomized controlled trials
Authors: Pastakia Khushnum , Kumar Saravana 
Published: December 2010

AbstractAim. Previous systematic reviews have examined the efficacy of exercise in improving the quality of life for patients with, and survivors of, breast cancer. This review sets out to determine the parameters of exercise programmes used in randomized controlled trials. Methods. A systematic review of randomized controlled trials was conducted. Only trials that reported significant improvement on the quality of life outcome were included. Data relating to the parameters of exercise (mode, duration, frequency and intensity and delivery method) were analyzed. Results. Nine randomized controlled trials were included in this review. Overall quality of the trials was average. Aerobic exercise was featured in eight of the nine trials and was used in combination with resistance training in four trials. All the trials were gym‐based, were under the supervision of a physiotherapist and included a warm‐up and cool‐down phase. Conclusions. This review concludes that aerobic exercise performed with or without weight training is a common feature of exercise programmes that report significant quality of life–related outcomes. The most commonly reported exercise parameters were three sessions per week, at moderate intensity being equivalent to 50% to 80% of the maximum heart rate for greater than 30 minutes. Copyright © 2010 John Wiley & Sons, Ltd.
Signs and symptoms of temporomandibular disorders and their impact on psychosocial status in non‐patient university student's population
Authors: Rodrigues Jeniffer Holley , Biasotto‐Gonzalez Daniela Aparecida , Bussadori Sandra Kalil , Mesquita‐Ferrari Raquel Agnelli , Fernandes Kristianne Porta Santos , Tenis Carlos Alberto , Martins Manoela Domingues 
Published: December 2010

AbstractBackground and Purpose. Temporomandibular disorders (TMD) exhibit a combination of signs and symptoms, mainly characterized by pain and dysfunction, which impairs the functional capacity of the mastication system. These symptoms may produce a negative impact on social activities, employment and leisure. The aim of this study was to early identify the signs and symptoms of TMD and their impact on daily life of non‐patient university students. Methods. Data were collected from 183 students of the dentistry course. The Axis II of the Research Diagnostic Criteria for Temporomandibular Disorders was administered and analyzed using Spearman test at a significance level of 0.05. Results. Among the 183 participants, 107 were women (58.47%) and 76 were men (41.53%). Age ranged from 18 to 47, with a mean age of 25.35 years. In relation to pain intensity and disability, 129 participants (70.88%) reported no pain in the previous 6 months. An analysis of depression revealed that 35 (19.67%) had moderate and 7 (3.83%) had severe depression. The assessment of nonspecific physical symptoms including pain revealed that nine (4.92%) exhibited moderate symptoms, and one (0.55%) exhibited severe symptoms. The nonspecific physical symptoms excluding items of pain analysis revealed that 44 (24.04%) exhibited moderate symptoms, and 91 (49.73%) exhibited severe. The functions reported as most adversely affected by jaw disability were yawning, eating hard foods, chewing, smiling and laughing. Regarding the habit, 64 (35%) confirmed having the nighttime and 59 daytime (32.3%) teeth grinding with a significant correlation with the four domains analyzed. A significant correlation was observed among all domains. Conclusion. This study analyzed a young population that exhibited para‐functional habits and nonspecific physical symptoms excluding pain that need some intervention since they could progress to a symptomatic TMD in future. Copyright © 2010 John Wiley & Sons, Ltd.
A new adaptive CUSUM control chart for detecting the multivariate process mean
Authors: Dai Yi , Luo Yunzhao , Li Zhonghua , Wang Zhaojun 
Published: December 2010

AbstractWe propose a new multivariate CUSUM control chart, which is based on self adaption of its reference value according to the information from current process readings, to quickly detect the multivariate process mean shifts. By specifying the minimum magnitude of the process mean shift in terms of its non‐centrality parameter, our proposed control chart can achieve an overall performance for detecting a particular range of shifts. This adaptive feature of our method is based on two EWMA operators to estimate the current process mean level and make the detection at each step be approximately optimal. Moreover, we compare our chart with the conventional multivariate CUSUM chart. The advantages of our control chart detection for range shifts over the existing charts are greatly improved. The Markovian chain method, through which the average run length can be computed, is also presented. Copyright © 2010 John Wiley & Sons, Ltd.
Generalized nonlinear ℋ︁∞synthesis condition with its numerically efficient solution
Authors: Zheng Qian , Wu Fen 
Published: December 2010

AbstractIn this paper, we will first derive a general synthesis condition for the output‐feedbackℋ︁∞control of smooth nonlinear systems. Computationally efficient ℋ︁∞control design procedure for a subclass of smooth nonlinear systems with polynomial vector field is then proposed by converting the resulting Hamilton‐Jacobi‐Isaacs inequalities from rational forms to their equivalent polynomial forms. Using quadratic Lyapunov functions, both the state‐feedback and output‐feedback problems will be reformulated as semi‐definite optimization conditions and locally tractable solutions can be obtained through sum‐of‐squares (SOS) programming. The proposed nonlinear ℋ︁∞design approach achieves significant relaxations on the plant structure compared with existing results in the literature. Moreover, the SOS‐based solution algorithm provides an effective computational scheme to break the bottleneck in solving nonlinear ℋ︁∞and optimal control problems. The proposed nonlinear ℋ︁∞control approach has been applied to several examples to demonstrate its advantages over existing nonlinear control techniques and its usefulness to engineering problems. Copyright © 2010 John Wiley & Sons, Ltd.
Tribological evaluation of HVOF thermal‐spray coatings as a hard chrome replacement
Authors: Picas Josep A. , Punset Miquel , Teresa Baile M. , Martín Enric , Forn Antonio 
Published: December 2010

AbstractHard chrome plating has been used in several different applications in industries that require abrasive sliding wear resistance, such as hydraulic pistons, shafts or bearings. However, the increasing environmental and worker safety pressures on electrolytic hard chrome are leading companies to adopt alternatives. The improvements of the high‐velocity‐oxy‐fuel (HVOF) thermal spray process allow the chromium coating replacement with a comparable or superior surface treatment and are more environmentally friendly. This HVOF process, as a flexible dry‐coating technology, avoids high‐volume waste streams and enables a flexible choice of coating material for each application. The cobalt–chromium‐cemented tungsten carbides are some of the easiest materials to spray and the WC‐10Co‐4Cr coatings have demonstrated superior performance over hard chrome with regard to mechanical and tribological properties. In this work, this coating has been deposited with a Sulzer Metco WokaJet‐400 kerosene fuel spray gun, and the spray conditions have been optimized in order to ensure the best properties of the coatings. The mechanical and tribological properties have been evaluated in coatings sprayed with four deposition conditions that involve different gas flow rates. The most wear‐resistant coating is obtained with those HVOF parameters that prevent decarburization of WC particles and, at the same time, allow an adequate agglomerate melting giving a good intersplat adhesion. The results indicate that HVOF‐sprayed WC‐CoCr coatings are a reliable alternative to electrolytic hard chrome (EHC) in the aeronautical industry to coat landing gear components. In particular, in the dry wear tests, the WC‐CoCr coatings outperform hard chrome coatings in wear resistance. Copyright © 2010 John Wiley & Sons, Ltd.
Modified robust variance estimator for generalized estimating equations with improved small‐sample performance
Authors: Wang Ming , Long Qi 
Published: December 2010

AbstractGeneralized estimating equations (GEE (Biometrika 1986; 73(1):13–22) is a general statistical method to fit marginal models for correlated or clustered responses, and it uses a robust sandwich estimator to estimate the variance–covariance matrix of the regression coefficient estimates. While this sandwich estimator is robust to the misspecification of the correlation structure of the responses, its finite sample performance deteriorates as the number of clusters or observations per cluster decreases. To address this limitation, Pan (Biometrika 2001; 88(3):901–906) and Mancl and DeRouen (Biometrics 2001; 57(1):126–134) investigated two modifications to the original sandwich variance estimator. Motivated by the ideas underlying these two modifications, we propose a novel robust variance estimator that combines the strengths of these estimators. Our theoretical and numerical results show that the proposed estimator attains better efficiency and achieves better finite sample performance compared with existing estimators. In particular, when the sample size or cluster size is small, our proposed estimator exhibits lower bias and the resulting confidence intervals for GEE estimates achieve better coverage rates performance. We illustrate the proposed method using data from a dental study. Copyright © 2010 John Wiley & Sons, Ltd.
Impacts of contextual and explicit instruction on preservice elementary teachers' understandings of the nature of science
Authors: Bell Randy L. , Matkins Juanita Jo , Gansneder Bruce M. 
Published: December 2010

AbstractThis mixed‐methods investigation compared the relative impacts of instructional approach and context of nature of science instruction on preservice elementary teachers' understandings. The sample consisted of 75 preservice teachers enrolled in four sections of an elementary science methods course. Independent variables included instructional approach to teaching nature of science (implicit vs. explicit) and the context of nature of science instruction (as a stand‐alone topic vs. situated within instruction about global climate change and global warming). These treatments were randomly applied to the four class sections along a 2 × 2 matrix, permitting the comparison of outcomes for each independent variable separately and in combination to those of a control group. Data collection spanned the semester‐long course and included written responses to pre‐ and post‐treatment administrations of the VNOS‐B, semi‐structured interviews, and a variety of classroom artifacts. Qualitative methods were used to analyze the data with the goal of constructing profiles of participants' understandings of the nature of science and of global climate change /global warming (GCC/GW). These profiles were compared across treatments using non‐parametric statistics to assess the relative effectiveness of the four instructional approaches. Results indicated that preservice teachers who experienced explicit instruction about the nature of science made statistically significant gains in their views of nature of science regardless of whether the nature of science instruction was situated within the context of GCC/GW or as a stand‐alone topic. Further, the participants who experienced explicit nature of science instruction as a stand‐alone topic were able to apply their understandings of nature of science appropriately to novel situations and issues. We address the implications of these results for teaching the nature of science in teacher preparation courses. © 2010 Wiley Periodicals, Inc., Inc. J Res Sci Teach 48: 414–436, 2011
A typology of undergraduate students' conceptions of size and scale: Identifying and characterizing conceptual variation
Authors: Swarat Su , Light Greg , Park Eun Jung , Drane Denise 
Published: December 2010

AbstractThe importance of “size and scale” in nanoscience and engineering has been recognized by both scientists and science educators. A solid understanding of this concept is key to the learning of nanoscience. Students, however, have been reported to have considerable difficulty grasping this concept; yet little is known regarding their state of understanding. To address this knowledge gap, we conducted a series of studies that were aimed at exploring the different ways students conceive of “size and scale” in the context of undergraduate nanoscience and engineering courses. Informed by Variation Theory of Learning (Marton and Booth, 1997), we identified four major categories (with two sub‐categories within each) of student conception—fragmented, linear, proportional, and logarithmic. These conception categories, together with the aspects of variation that characterize and distinguish them, are summarized in a typology. In addition to serving as a diagnostic tool to describe students' understanding, this typology can also be used to guide the development of instructional interventions that facilitate students to move toward a more sophisticated understanding of “size and scale.” © 2011 Wiley Periodicals, Inc., Inc. J Res Sci Teach 48: 512–533, 2011
Implementation of computational methods for designing potential inhibitors against human p38α protein
Authors: M Durga Devi , Pradhan Dibyabhaba , Munikumar Manne , Umamaheswari Amineni 
Published: December 2010

Abstractp38α, a non-receptor serine/threonine kinase, plays an essential role in cell proliferation, cell differentiation, apoptosis, production of cytokines such as IL1β and TNFα, senescence and tumorigenesis. Over expression of p38α enhances the production of cytokines, leading to inflammation causing cancers. Therefore, the protein p38α is selected as a target for the inhibition of progression of inflammatory cancers. SB203580, BIRB796, 2H-quinolizine-2-one, 7-alkyl-1,5-bis–aryl-pyrazolo pyridinones, aML3403, N-pyrimidyl amides, Fused pyrazoles, SD0006, 4-3-(4-fluoro phenyl )-1H-pyrazol-4-yl)pyridine are the nine published inhibitors for the p38α, but they show side effects like liver toxicity and the development of lung tumors, particularly in smokers, some of which are in the preclinical stage. A small molecule library of 3495 structural analogs of the nine published inhibitors was prepared for ligand based virtual screening. Multiple conformations of the ligands were generated and conformations with ADME violations were discarded. The optimized ligand conformations were docked flexibly into the active site of optimized p38α crystal structure. Fourteen lead molecules obtained were ranked based on XP G-score and binding orientation. In comparison with the nine existing inhibitors, lead ‘1’ (N-(3-Benzooxazol-2-yl-4-hydroxy-phenyl) 2ptolyloxyacetamide) had the highest binding affinity among the lead molecules with XP Gscore of -9.38 kcal/mol and formed four hydrogen bonds: one with each of Ala 51, Glu71 and Asp168 and one water bond (position 420) with binding mode which complements well the crystallographic data of human p38α. The docking result shows the potency of lead ‘1’ as a promising inhibitor for regulating the activity of p38α.
In silico identification of potential inhibitors for human aurora kinase b
Authors: G Mahesh Babu , N. Pradeep , Pradhan Dibyabhaba , MuniKumar Manne , Umamaheswari Amineni 
Published: December 2010

AbstractCell cycle progression through mitosis and meiosis involves regulation by serine/threonine kinases from the aurora family. Aurora kinase b (Aurkb) is mainly involved in the proper segregation of chromosomes during mitosis as well as meiosis. However, over expression of Aurkb leads to the unequal distribution of genetic information creating aneuploid cells, a hallmark of cancer. Thus, Aurkb can be used as an effective molecular target for computer-aided drug discovery against cancer. Existing Aurkb inhibitors are less efficient, hence an in silico work was carried out to identify novel potent inhibitors. Three published inhibitors azd1152, zm447439 and N-(4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy) quinazolin- 4-yl] amino} phenyl) benzamide were subjected to high throughput virtual screening of over 1 million entries from a ligand info meta database, to generate a 1161 compound library. The crystal structure was optimized and energy was minimized applying an OPLS force field in Maestro v9.0. Molecular docking using Glide was performed to predict the binding orientation of the prepared ligand molecule into a grid of 20*20*20 Å created around the centroid of the optimized human Aurkb protein. Nine lead molecules with good binding affinity with human Aurkb were identified. In silico pharmacokinetics study for these nine lead molecules has shown no ADME violation. Analysis of lead ‘1’- human Aurkb docking complex has revealed a XP Gscore of -10.20 kcal/mol with a highly stabilized hydrogen bond network with Asp218 and Ala157 and good Van der wall interactions. The docking complex coincides well with the native co- crystallized human Aurkb and inhibitor zm447439 complex. Thus, lead 1 would be highly useful for developing potential drug molecules for the treatment of cancer.
Identification of potent inhibitors for p38δ MAPkinase of human through in silico analysis
Authors: M Naga Lakshmi , Munikumar Manne , Pradhan Dibyabhaba , Umamaheswari Amineni 
Published: December 2010

AbstractP38δ Mitogen activated protein kinase is a serine/threonine protein kinase that participates in signaling cascades, mediating cellular responses to cytokinines, UV radiation, hyperosmotic stress, inducing keratinocyte differentiation and regulating apoptosis. Over expression of p38δ leads to tumor development by impairing the ERK1/2 –AP1 pathway that is critically linked to the control of cell proliferation and tumorigenesis on skin which was experimentally proven in knockout mice. Therefore, herein, a computational approach was undertaken to design novel inhibitors against p38delta for effective cancer therapy. The tertiary structure of p38δ was retrieved from a protein databank and active sites were predicted from CASTP and site finder and were optimized by applying OPLS force field in Maestro v9.0. Four p38δ specific inhibitors 4-(4-(2-(cyclopentylamino)pyrimidin-4-yl)-1H-pyrazol-3-yl)cyclohexanol,(R)-2-(sec-butylamino)-N-(2-methyl-5-(methylcarbamoyl)phenyl)thiazole-5-carboxamide, BIRB796 and ANP were selected from the literature for high throughput screening against one million compounds from the Ligand.Info metadatabase to generate an in-house library of 1515 structural analogs. The ligand library was prepared using LigPrep and compounds with ADME violations were discarded from the dataset. The candidates from the optimized ligand dataset were docked into the active site of p38δ through sequential application of Glide HTVS, SP and XP methods that penalizes more stringently for minor steric classes subsequently. Through comparative analysis of binding orientations and the XP G-score of the protein-ligand docking complexes with published inhibitor data, 4 lead molecules with the lowest docking scores(-12.12,-10.06,-9.47 and-9.36) are proposed to be considered as potential inhibitors of p38δ. The lead molecules would be highly encouraging for future cancer therapy if tested in animal models.
Genomic regions associated with antibody response to sheep red blood cells in the chicken
Authors: Dorshorst B. J. , Siegel P. B. , Ashwell C. M. 
Published: December 2010

Summary F
1 and F2 populations were generated by crossing two lines of chickens divergently selected from a common founder population for 32 generations for either high or low antibody response 5 days post‐injection of a non‐pathogenic antigen, sheep red blood cells (SRBCs). The number of loci with major effects on day 5 SRBC titers was estimated to be more than 7 in this population. There was a significant association between MHC haplotype and day 5 antibody titers as well as body weight at sexual maturity. A significant difference between reciprocal F2 crosses for both 5‐ and 12‐day antibody titers suggests that sex chromosome and/or parent of origin effects on autosomal loci have an important role in immune response. A single marker‐trait association analysis on 1024 genetic markers and 128 F2 individuals detected 11 genomic regions associated with antibody response traits and 17 regions associated with body weight gain. Several of the genomic regions identified as being associated with antibody response have been described previously, while novel regions associated with antibody response were identified on chromosomes 11 and 24. Based on the lack of overlap of the regions associated with body weight and antibody response, we conclude that while these phenotypes are inversely correlated in the selected lines, they are controlled by distinct genetic loci and may be reflective of intense selection pressure on loci affecting the partitioning of nutrients between the immune system and growth pathways.
Reversible posterior leucoencephalopathy syndrome in an elderly male on sunitinib therapy
Authors: Padhy Biswa M. , Shanmugam Saravana P. , Gupta Yogendra K. , Goyal Aman 
Published: December 2010

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT• Agents inhibiting vascular endothelial growth factor can lead to development of reversible posterior leucoencephalopathy syndrome (RPLS).• Few cases of sunitinib‐induced RPLS have been reported previously.WHAT THIS STUDY ADDS• A case of sunitinib‐induced RPLS in an elderly man is described in this study.• Elevated blood pressure at presentation occurs in most cases of sunitinib‐induced RPLS.AIMS Reversible posterior leucoencephalopathy syndrome (RPLS) has been reported following the use of anti‐vascular endothelial growth factor (VEGF) agents such as bevacizumab, sorafinib and sunitinib. In this report we present a case of RPLS that occurred in an elderly male on sunitinib therapy.METHODS Other case reports of sunitinib‐induced RPLS were reviewed and causality assessment was carried out using the World Health Organization‐Uppsala Monitoring Centre criteria and the Naranjo algorithm.RESULTS Only a few cases of sunitinib‐induced RPLS had been reported previously and elevated blood pressure at presentation was common in most of the patients. Our case was clinically similar to the earlier reports and the adverse reaction had a ‘probable’ relationship with sunitinib intake.CONCLUSIONS Physicians should monitor and manage elevated blood pressure in patients with sunitinib‐induced RPLS.