bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Three‐Component Reactions of Isochromenylium Tetrafluoroborates via Non‐Classical [4 + 2]‐Intermediates: Mild One‐Step Metal‐Free Synthesis of Functionalized Dihydronaphthalenes and Tetrahydronaphthalenes.
Authors: Hu Zhi‐Long , Yang Zhen‐Yu , Wang Shaozhong , Yao Zhu‐Jun 
Published: April 2011

AbstractThree component reaction of stable isochromenylium tetrafluoroborate (I) with aliphatic aldehydes (II), (VI) or (XI) and nitriles (III) or (XIV) proceeds under mild metal‐free conditions to give a wide variety of functionalized dihydronaphthalene derivatives.
ChemInform Abstract: Electrophilic Carbocyclization of Aryl Propargylic Alcohols: A Facile Synthesis of Diiodinated Carbocycles and Heterocycles.
Authors: Zhu Hai‐Tao , Ji Ke‐Gong , Yang Fang , Wang Li‐Jing , Zhao Shu‐Chun , Ali Shaukat , Liu Xue‐Yuan , Liang Yong‐Min 
Published: April 2011

AbstractThe presence of a trace of water is essential for the reaction.
ChemInform Abstract: Enantioselective Synthesis of 2,2,5‐Tri‐ and 2,2,5,5,‐Tetrasubstituted Tetrahydrofurans via [4 + 2] Cycloaddition and Ring‐Opening Cross‐Metathesis.
Authors: Benjamin Noah M. , Martin Stephen F. 
Published: April 2011

AbstractThe cycloaddition reaction of the chiral and racemic vinyl sulfoxide with various furan derivatives according to the sequence A) + B) proceeds mostly endo‐selectively.
ChemInform Abstract: Photoinduced Rearrangements of 3,3′‐Bis(arylbenzofurans).
Authors: Auzias Mathieu , Haeussinger Daniel , Neuburger Markus , Wegner Hermann A. 
Published: April 2011

AbstractThe reaction under inert nitrogen atmosphere using Rayonet reactor leads to the benzonaphthofurans in high yields.
ChemInform Abstract: Nucleophilic Ring‐Opening of Epoxide and Aziridine Acetates for the Stereodivergent Synthesis of β‐Hydroxy and β‐Amino γ‐Lactams.
Authors: Bisol Tula B. , Bortoluzzi Adailton J. , Sa Marcus M. 
Published: April 2011

AbstractEfficient methods to prepare β,γ‐disubstituted γ‐lactams with syn and anti configuration are reported.
ChemInform Abstract: FeCl3‐Promoted Alkylation of Indoles by Enamides.
Authors: Niu Tianmin , Huang Lehao , Wu Tianxing , Zhang Yuhong 
Published: April 2011

AbstractThe Fe(III)‐catalyzed addition of indole derivatives towards enamides can afford either mono‐ (III) or bisadducts (VII) depending on the amount of indole used.
ChemInform Abstract: An Atom‐Economical Access to β‐Heteroarylated Ketones from Propargylic Alcohols via Tandem Ruthenium/Indium Catalysis.
Authors: Trost Barry M. , Breder Alexander 
Published: April 2011

AbstractA variety of secondary propargyl alcohols reacts with furan and indole derivatives to yield the products with complete chemoselectivity.
ChemInform Abstract: Titanium‐Catalyzed Stereoselective Synthesis of Spirooxindole Oxazolines.
Authors: Badillo Joseph J. , Arevalo Gary E. , Fettinger James C. , Franz Annaliese K. 
Published: April 2011

AbstractReaction of various isatins with 5‐methoxyoxazoles proceeds regioselectively and with high diastereoselectivity to afford spiro products (III) and (V).
ChemInform Abstract: 4,5‐Dihydroxyimidazolidin‐2‐ones in the Reaction of α‐Ureidoalkylation of N‐(Carboxyalkyl)‐, N‐(Hydroxyalkyl)‐, and N‐(Aminoalkyl)ureas. Part 6. Tandem Sequence of α‐Ureidoalkylation and Esterification in the Course of the Reaction of N‐(Carboxyalkyl)ureas with 4,5‐Dihydroxy‐1,3‐dimethyl‐4,5‐diphenylimidazolidin‐2‐one in Alcohols.
Authors: Baranov V. V. , Nelyubina Yu. V. , Kravchenko A. N. , Makhova N. N. 
Published: April 2011

AbstractThe DHI‐analogues (IV), (VI), and (VII) are synthesized with a new substitution pattern.
ChemInform Abstract: Microwave Assisted One‐Pot Synthesis of Some Novel 2,5‐Disubstituted 1,3,4‐Oxadiazoles as Antifungal Agents.
Authors: Sangshetti Jaiprakash N. , Chabukswar Aniruddha R. , Shinde Devanand B. 
Published: April 2011

AbstractThis is the first report of a sodium bisulfite promoted synthesis of 2,5‐disubstituted 1,3,4‐oxadiazoles.
ChemInform Abstract: Design and Efficient Synthesis of A‐278637 Derivatives as Potential Potassium Channel Opener.
Authors: Li Tuanjie , Feng Xiaodong , Yao Changsheng , Yu Chenxia , Jiang Bei , Tu Shujiang 
Published: April 2011

AbstractFollowing a promising scaffold, a series of novel thieno[3,2‐b]quinoline derivatives (IV) are synthesized by one‐pot three‐component reaction under solvent‐ and catalyst‐free conditions.
ChemInform Abstract: Condensed Diazepines. Synthesis of 1‐Aryl‐3,5‐dihydro‐4H‐1‐benzofuro[2,3‐d][1,2]diazepin‐4‐ones.
Authors: Eresko A. B. , Tolkunov V. S. , Tolkunov S. V. 
Published: April 2011

AbstractThe title compounds, e.g. (II) and (IV), are available from esters or acids by using hydrazine acetate or hydrate as reagent.
ChemInform Abstract: Intramolecular Iodoetherification of Ene or Diene Ketals: Facile Synthesis of Spiroketals.
Authors: Fujioka Hiromichi , Nakahara Kenji , Hirose Hideki , Hirano Kie , Oki Tomohiro , Kita Yasuyuki 
Published: April 2011

AbstractChiral spiroketals (II), (VI) and (IX) are synthesized based on remote asymmetric induction.
ChemInform Abstract: Expected and Unexpected Reactions of 1,3‐Benzothiazine Derivatives. Part 2. Formation of Isomeric 5,6‐Dihydro‐1,5‐benzothiazocines.
Authors: Fodor Lajos , Csomos Peter , Csampai Antal , Sohar Pal , Holczbauer Tamas , Kalman Alajos 
Published: April 2011

AbstractThe synthesis of 1,5‐benzothiazocines (VI) via ring‐enlargement of benzothiazines (III) is demonstrated.
ChemInform Abstract: Gold‐Catalyzed Cyclopenta‐ and Cycloheptannulation Cascades: A Stereocontrolled Approach to the Scaffold of Frondosins A and B.
Authors: Garayalde David , Krueger Karolin , Nevado Cristina 
Published: April 2011

AbstractGold‐catalyzed, highly diastereoselective, three‐step cascade reactions of propargyl acetates with 1,4‐dienes or alkenes give five‐ or seven‐membered carbocycles, respectively.
ChemInform Abstract: Two Dimeric Lignans with an Unusual α,β‐Unsaturated Ketone Motif from Zanthoxylum podocarpun and Their Inhibitory Effects on Nitric Oxide Production.
Authors: Zhou Xiao‐Jiang , Chen Xiao‐Liang , Li Xue‐Song , Su Jia , He Jiang‐Bo , Wang Yue‐Hu , Li Yan , Cheng Yong‐Xian 
Published: April 2011

AbstractTwo new dimeric lignans, zanthpodocarpins A (Ia) and B (Ib), are isolated along with a series of known lignans from the title plant bark.
ChemInform Abstract: Total Synthesis of (‐)‐Brevisin: A Concise Synthesis of a New Marine Polycyclic Ether.
Authors: Kuranaga Takefumi , Ohtani Naohito , Tsutsumi Ryosuke , Baden Daniel G. , Wright Jeffrey L. C. , Satake Masayuki , Tachibana Kazuo 
Published: April 2011

AbstractThe first total synthesis of (I) succeeds in 29 steps from commercially available deoxy‐D‐ribose.
Removal Of methylene blue dye from simulated wastewater by alginic acid fiber as adsorbent: Equilibrium, kinetic, and thermodynamic studies
Authors: Guo Chunxiang , Kong Qingshan , Gao Jixian , Ji Quan , Xia Yanzhi 
Published: April 2011

AbstractAlginic acid fiber was used as a novel adsorbent to remove methylene blue from aqueous solution, and adsorption mechanisms were investigated. System variables, including contact time, pH, temperature, and initial concentration were examined to investigate the effect on adsorption in batch experiments. The results showed that equilibrium reached in less than 20 min and pH significantly influenced the equilibrium value. Langmuir, Freundlich, and Temkin isotherm models were employed to analyse the isotherm behaviours. It was found the isotherm behaviours conform to Freundlich and Temkin models well, indicating a chemisorption process. Pseudo‐first‐order, pseudo‐second‐order, and intraparticle diffusion models were employed to investigate kinetic behaviours. The kinetic behaviour is best described by pseudo‐second‐order model. Thermodynamic parameters indicate that the process is spontaneous and exothermic.
A modified Peng–Robinson equation of state for phase equilibrium calculation of liquefied, synthetic natural gas, and gas condensate mixtures
Authors: Haghtalab Ali , Mahmoodi Peyman , Mazloumi Seyed Hossein 
Published: April 2011

AbstractA modified Peng–Robinson equation of state, MPR2 EOS, is introduced by incorporating a new alpha function and a temperature dependent function for covolume, b. The modified cubic EOS has three input per each substance: critical temperature, critical pressure, and acentric factor. The coefficients of temperature dependence of the alpha and beta functions, relating to the parameters a and b of the new cubic EOS, are obtained by simultaneous fitting of saturated experimental vapour pressure and liquid density data for several pure components. The percent absolute average deviation (AAD%) of 1.38, 4.80 and 2.89 are obtained to correlation of the saturation vapour pressure, liquid density and vapour volume, respectively. Also the ADD% of 2.575 is computed for prediction of saturation enthalpy of vapourisation of the pure compounds. For calculation of phase equilibrium of mixture, the modified PR EOS is used for prediction of liquid density of the LNG mixtures. Also the new EOS is applied for construction of the phase envelop of synthetic natural gas, SNG, mixtures and calculation vapour–liquid equilibria of gas condensates. The results demonstrate that the new MPR2 EOS can be used for calculation of vapour–liquid equilibrium of pure components and mixtures with good accuracy.
Design Strategies for Bivalent Ligands Targeting GPCRs
Authors: Shonberg Jeremy , Scammells Peter J. , Capuano Ben 
Published: April 2011

AbstractSpecifically designed bivalent ligands targeting G protein‐coupled receptor (GPCR) dimeric structures have become increasingly popular in recent literature. The advantages of the bivalent approach are numerous, including enhanced potency and receptor subtype specificity. However, the use of bivalent ligands as potential pharmacotherapeutics is limited by problematic molecular properties, such as high molecular weight and lipophilicity. This Minireview focuses on the design of bivalent ligands recently described in the literature; discussing the choice of lead pharmacophore, the position and nature of the attachment point for linking the two pharmacophore units, and the length and composition of the spacer group. Furthermore, this Minireview distils the molecular descriptors of the bivalent ligands that exhibit in vivo activity, as well as highlights their ability to access the central nervous system.
Nutzung von Systemreserven bei der Schnittkraftermittlung an Schubwänden
Authors: Jäger Wolfram 
Published: April 2011

AbstractDer Beitrag zeigt Möglichkeiten zur Aktivierung von systementlastenden Reserven auf der Seite der Schnittgrö�enermittlung bei Schubwänden auf. Als Grundlage dient ein Stabwerkmodell [1], welches durch unterschiedliche Herangehensweisen modifiziert wird. Dadurch kann eine Schubwand, die bei klassischer Schnittkraftermittlung am Kragarm mit horizontalen Lasten aus Wind rechnerisch zu hohe Biegemomente bekommt, näher an den wirklichen Kraftverlauf herangebracht werden.Utilisation of system reserves in the structural analysis of shear walls. This report shows several options for the mobilization of structure‐reliving resources on the side of structural analysis of shear walls. This is based on a frame model [1], which is modified by different approaches. Thus, a shear wall, which gets too high bending moments from the structural analysis on the classical cantilever beam with horizontal wind loads, can be pushed closer to the real state.
Ansätze zur Ermittlung vertikaler Einwirkungen auf Schubwände
Authors: Ortlepp Sebastian 
Published: April 2011

AbstractDieser Beitrag zeigt, wie der Lasteintrag von einer Deckenplatte in eine darunter liegende Wand durch unterschiedliche Parameter beeinflusst werden kann. Durch die vergleichende Betrachtung verschiedener Herangehensweisen an die Ermittlung von Lastgrö�en und ‐position werden Reserven dargestellt, welche sich bei dem Nachweis der tragenden Schubwand positiv auswirken können.Approaches for determining vertical loads on shear walls. This paper shows how the load introduction from a ceiling into a wall beneath may be influenced by different parameters. Through a comparative analysis of different approaches for the determination of load size and position several reserves are shown, which could be affected as positive by the verifying of a shear wall.
Rhodium and Iridium Complexes with α‐Diketimine Ligands: Oxidative Addition of H2 and O2
Authors: Penner Anna , Braun Thomas 
Published: April 2011

AbstractThe treatment of [M(μ‐Cl)(coe)2]2 (M = Rh, Ir; coe = cyclooctene) with the α‐diketimines ArN=C(Me)C(Me)=NAr (Ar = Ph, Xy; Xy = 2,6‐Me2C6H3) in thf, followed by the addition of CNtBu, gave the α‐diketimine complexes [M(Cl){ArN=C(Me)C(Me)=NAr} (CNtBu)] (1: M = Rh, Ar = Ph; 2: M = Rh, Ar = Xy; 3: M = Ir, Ar = Xy). The reaction of 3 with dihydrogen resulted in the formation of the iridium dihydrido complex [Ir(Cl)(H)2{XyN=C(Me)C(Me)=NXy}(CNtBu)] (4). The complexes 2 and 3 reacted with O2 or 18O2 to yield the peroxido complexes [M(Cl)(O2){XyN=C(Me)C(Me)=NXy}(CNtBu)] (5a: M = Rh; 6a: M = Ir) and [M(Cl)(18O2){XyN=C(Me)C(Me)=NXy}(CNtBu)] (5b: M = Rh; 6b: M = Ir), respectively. All of the complexes were characterized by NMR and IR spectroscopy. In addition, complexes 3 and 5a were characterized by X‐ray crystallography.
Synthesis of 8‐Phenoxy‐2′‐deoxyguanosine Nucleoside Analogues
Authors: Dahlmann Heidi A. , Sturla Shana J. 
Published: April 2011

AbstractNucleobase adducts, which form in vivo by nucleophilic attack of nucleobases on electrophilic chemical species, can impact on the conformation and biological influences of the adducted nucleoside. Contemporary studies aim to address the occurrence and relevance of 8‐phenoxypurine adducts. However, preparative techniques for synthesizing these nucleosides have not previously been described. Reported herein is a relatively facile synthesis of 8‐dG phenol adducts using a wide variety of electron‐donating, electron‐withdrawing, and sterically demanding phenols.
Squalenoyl Gemcitabine Monophosphate: Synthesis, Characterisation of Nanoassemblies and Biological Evaluation (Eur. J. Org. Chem. 14/2011)
Authors: Caron Joachim , Lepeltier Elise , Reddy L. Harivardhan , Lepêtre‐Mouelhi Sinda , Wack Séverine , Bourgaux Claudie , Couvreur Patrick , Desmaële Didier 
Published: April 2011

AbstractThe cover picture shows the overall process leading to the elaboration of a squalenoyl nanomedicine, going from the chemical modification of natural squalene to the biological evaluation of the drug in mice. On a background of nanoparticles observed by electron microscopy, the synthesis of squalenoylgemcitabine monophosphate is depicted in a reaction scheme. This amphiphilic molecule self‐assembles to nanoparticles of about 100 nm in aqueous solution, as shown in the two vials. In the central circle, unilamellar liposomes with a membrane thickness of about 70 Å are seen from a microscope lens. Details are discussed in the article by D. Desmaële et al. on p. 2615 ff.
Axonal pathways linked to therapeutic and nontherapeutic outcomes during psychiatric deep brain stimulation
Authors: Lujan J. Luis , Chaturvedi Ashutosh , Malone Donald A. , Rezai Ali R. , Machado Andre G. , McIntyre Cameron C. 
Published: April 2011

AbstractObjective:The underlying hypothesis of our work is that specific clinical neuropsychiatric benefits can be achieved by selective activation of specific axonal pathways during deep brain stimulation (DBS). As such, the goal of this study was to develop a method for identifying axonal pathways whose activation is most likely necessary for achieving therapeutic benefits during DBS.Experimental design:Our approach combined clinical data, diffusion tensor tractography, and computer models of patient‐specific neurostimulation to identify particular axonal pathways activated by DBS and determine their correlations with individual clinical outcome measures. We used this method to evaluate a cohort of seven treatment‐resistant depression patients treated with DBS of the ventral anterior internal capsule and ventral striatum (VC/VS).Principal observations:Clinical responders exhibited five axonal pathways that were consistently activated by DBS. All five pathways coursed lateral and medial to the VS or dorsal and lateral to the nucleus accumbens; however, details of their specific trajectories differed. Similarly, one common pathway was identified across nonresponders.Conclusions:Our method and preliminary results provide important background for studies aiming to expand scientific characterization of neural circuitry associated with specific psychiatric outcomes from DBS. Furthermore, identification of pathways linked to therapeutic benefit provides opportunities to improve clinical selection of surgical targets and stimulation settings for DBS devices. Hum Brain Mapp, 2012. © 2011 Wiley Periodicals, Inc.
Frontal and posterior cingulate metabolic impairment in the behavioral variant of frontotemporal dementia with impaired autonoetic consciousness
Authors: Bastin Christine , Feyers Dorothée , Souchay Céline , Guillaume Bénédicte , Pepin Jean‐Louis , Lemaire Christian , Degueldre Christian , Collette Fabienne , Salmon Eric 
Published: April 2011

AbstractAlthough memory dysfunction is not a prominent feature of the behavioral variant of frontotemporal dementia (bv‐FTD), there is evidence of specific deficits of episodic memory in these patients. They also have problems monitoring their memory performance. The objective of the present study was to explore the ability to consciously retrieve own encoding of the context of events (autonoetic consciousness) and the ability to monitor memory performance using feeling‐of‐knowing (FOK) in bv‐FTD. Analyses of the patients' cerebral metabolism (FDG‐PET) allowed an examination of whether impaired episodic memory in bv‐FTD is associated with the frontal dysfunction characteristic of the pathology or a dysfunction of memory‐specific regions pertaining to Papez's circuit. Data were obtained from eight bv‐FTD patients and 26 healthy controls. Autonoetic consciousness was evaluated by Remember responses during the recognition memory phase of the FOK experiment. As a group, bv‐FTD patients demonstrated a decline in autonoetic consciousness and FOK accuracy at the chance level. While memory monitoring was impaired in most (seven) patients, four bv‐FTD participants had individual impairment of autonoetic consciousness. They specifically showed reduced metabolism in the anterior medial prefrontal cortex, the left dorsolateral prefrontal cortex (near the superior frontal sulcus), parietal regions, and the posterior cingulate cortex. These findings were tentatively interpreted by considering the role of the metabolically impaired brain regions in self‐referential processes, suggesting that the bv‐FTD patients' problem consciously retrieving episodic memories may stem at least partly from deficient access to and maintenance/use of information about the self. Frontal and posterior cingulate metabolic impairment in the behavioral variant of frontotemporal dementia with impaired autonoetic consciousness Hum Brain Mapp, 2011. © 2011 Wiley‐Liss, Inc.
Resting state basal ganglia network in idiopathic generalized epilepsy
Authors: Luo Cheng , Li Qifu , Xia Yang , Lei Xu , Xue Kaiqing , Yao Zhiping , Lai Youxiu , Martı´nez‐Montes Eduardo , Liao Wei , Zhou Dong , Valdes‐Sosa Pedro A. , Gong Qiyong , Yao Dezhong 
Published: April 2011

AbstractThe basal ganglia, a brain structure related to motor control, is implicated in the modulation of epileptic discharges generalization in patients with idiopathic generalized epilepsy (IGE). Using group independent component analysis (ICA) on resting‐state fMRI data, this study identified a resting state functional network that predominantly consisted of the basal ganglia in both healthy controls and patients with IGE. In order to gain a better understanding of the basal ganglia network(BGN) in IGE patients, we compared the BGN functional connectivity of controls with that of epilepsy patients, either with interictal epileptic discharges (with‐discharge period, WDP) or without epileptic discharge (nondischarge period, NDP) while scanning. Compared with controls, functional connectivity of BGN in IGE patients demonstrated significantly more integration within BGN except cerebellum and supplementary motor area (SMA) during both periods. Compared with the NDP group, the increased functional connectivity was found in bilateral caudate nucleus and the putamen, and decreases were observed in the bilateral cerebellum and SMA in WDP group. In accord with the proposal that the basal ganglia modulates epileptic discharge activity, the results showed that the modulation enhanced the integration in BGN of patients, and modulation during WDP was stronger than that during NDP. Furthermore, reduction of functional connectivity in cerebellum and SMA, the abnormality might be further aggravated during WDP, was consistent with the behavioral manifestations with disturbed motor function in IGE. These resting‐state fMRI findings in the current study provided evidence confirming the role of the BGN as an important modulator in IGE. Hum Brain Mapp, 2011. © 2011 Wiley‐Liss, Inc.
Fracture risk in men with prostate cancer: A population-based study
Authors: Melton L Joseph , Lieber Michael M , Atkinson Elizabeth J , Achenbach Sara J , Zincke Horst , Therneau Terry M , Khosla Sundeep 
Published: April 2011

Abstract
Fractures are increased among men with prostate cancer, especially those on androgen-deprivation therapy (ADT), but few data are available on men with localized prostate cancer. The purpose of this investigation was to estimate fracture risk among unselected community men with prostate cancer and systematically assess associations with ADT and other risk factors for fracture. In a population-based retrospective cohort study, 742 Olmsted County, MN, men with prostate cancer first diagnosed in 1990–1999 (mean age 68.2 ± 8.9 years) were followed for 6821 person-years. We estimated cumulative fracture incidence, assessed relative risk by standardized incidence ratios, and evaluated risk factors in time-to-fracture regression models. All together, 482 fractures were observed in 258 men (71 per 1000 person-years). Overall fracture risk was elevated 1.9-fold, with an absolute increase in risk of 9%. Relative to rates among community men generally, fracture risk was increased even among men not on ADT but was elevated a further 1.7-fold among ADT-treated compared with untreated men with prostate cancer. The increased risk following various forms of ADT was accounted for mainly by associations with pathologic fractures (14% of all fractures). Among men not on ADT (62% of the cohort), more traditional osteoporosis risk factors were implicated. In both groups, underlying clinical characteristics prompting different treatments (indication bias) may have been partially responsible for the associations seen with specific therapies. To the extent that advanced-stage disease and pathologic fractures account for the excess risk, the effectiveness of fracture prevention among men with prostate cancer may be limited. © 2011 American Society for Bone and Mineral Research