bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immediate Loading of Dental Implants Placed in Periodontally Infected and Non‐Infected Sites: A 4‐Year Follow‐Up Clinical Study
Authors: Crespi Roberto , Capparè Paolo , Gherlone Enrico 
Published: April 2010

Background: The aim of the present study is to compare the outcomes of immediate loading of implants in replacing teeth with and without chronic periodontal lesions at 4 years of follow‐up.Methods: Thirty‐seven patients were included in this study. A total of 275 implants were placed and immediately loaded in extraction sockets, 197 in periodontally infected sites (infected sites group [IG]), and 78 implants in non‐infected sites (non‐infected sites group [NG]). Marginal bone levels and clinical parameters (plaque accumulation and bleeding index) were evaluated at baseline and 12, 24, and 48 months after implant placement. Comparisons between IG and NG values over time were performed by the Student two‐tailed t test.Results: At 48 months of follow‐up, the IG presented a survival rate of 98.9% because two implants were lost 1 month after placement; the NG reported a survival rate of 100%. The marginal bone level was 0.79 ± 0.38 mm for the IG and 0.78 ± 0.38 mm for the NG, plaque accumulation was 0.72 ± 0.41 for the IG and 0.71 ± 0.38 for the NG, and the bleeding index was 0.78 ± 0.23 for the IG and 0.75 ± 0.39 for the NG. No statistically significant differences were reported between the IG and NG over time and between time points.Conclusion: At 48 months of follow‐up, dental implants that were placed and immediately loaded in periodontally infected sockets showed no significant differences compared to implants placed in uninfected sites.
Effects of Scaling and Root Planing and Subantimicrobial Dose Doxycycline on Gingival Crevicular Fluid Levels of Matrix Metalloproteinase‐8, ‐13 and Serum Levels of HsCRP in Patients With Chronic Periodontitis
Authors: Tüter Gülay , Serdar Muhittin , Kurtiş Bülent , Walker Stephen G. , Atak Ayşegül , Toyman Utku , Pınar Selin , Aykan Tuba 
Published: April 2010

Background: This study evaluates the efficacy of subantimicrobial dose doxycycline (SDD) in conjunction with scaling and root planing (SRP) on gingival crevicular fluid (GCF) levels of matrix metalloproteinase (MMP)‐8 and ‐13 and on serum levels of high‐sensitivity C‐reactive protein (HsCRP) in patients with chronic periodontitis (CP).Methods: A total of 41 patients with CP and 17 healthy individuals were included in this randomized controlled trial. CP patients were randomly distributed into two groups. Study groups were established as Group I with SRP+placebo, Group II with SRP+SDD, and Group III as control. All CP patients received two regimens of SRP and Group II patients also received SDD for 6 weeks. At baseline and 6 weeks, GCF and blood were collected and clinical indices were recorded. The HsCRP level was assayed in the plasma on a nephelometer. The GCF levels of MMPs were assayed by an enzyme‐linked immunosorbent assay.Results: Statistically significant differences in plaque index, gingival index (GI), probing depth (PD), GCF volumes, GCF MMP levels, and serum levels of HsCRP between pre‐treatment and post‐treatment were noted in both groups. Between groups there was a statistically significant decrease in PD, GI, and GCF levels of MMP‐8 favoring the group receiving SDD adjunctive to SRP (P <0.05).Conclusion: In this study, greater improvement was detected for PD, GI, and GCF levels of MMP‐8 when using SRP+SDD compared to SRP+placebo.
The Effect of Periodontal Treatment on Serum Leptin, Interleukin‐6, and C‐Reactive Protein
Authors: Shimada Yasuko , Komatsu Yasutaka , Ikezawa‐Suzuki Ikuyo , Tai Hideaki , Sugita Noriko , Yoshie Hiromasa 
Published: April 2010

Background: Previous studies suggest that periodontitis is closely related to obesity and metabolic syndrome. Leptin, a pleiotrophic hormone produced by adipose tissue, has been reported to be related to periodontitis. This study investigates the effects of periodontal treatment on the serum levels of leptin and other cytokines in patients with chronic periodontitis (CP).Methods: Serum samples were taken from 33 CP patients (22 non‐smokers, 11 smokers) and 18 healthy subjects. The serum leptin, adiponectin, tumor necrosis factor‐α, interleukin (IL)‐6, and C‐reactive protein (CRP) levels were measured before and after non‐surgical periodontal treatment.Results: Significant differences between healthy and CP patients were found in serum leptin, IL‐6, and CRP levels (P = 0.0018, P = 0.0064, and P = 0.0095, respectively). The serum leptin level was associated with mean probing depth, mean clinical attachment level, mean alveolar bone loss, and body mass index. There were significant associations between serum leptin levels and IL‐6 and CRP levels. After non‐surgical periodontal treatment, serum leptin, IL‐6, and CRP levels were significantly decreased (mean ± SD before and after, P value, respectively: leptin, 8.02 ± 5.5, 7.10 ± 4.4, P = 0.015; IL‐6, 1.73 ± 1.02, 1.36 ± 0.73, P = 0.048; and CRP, 802.0 ± 1065, 491.2 ± 479.3, P = 0.047).Conclusions: Periodontal treatment is effective in reducing serum leptin, IL‐6, and CRP levels. The results suggest that leptin, IL‐6, and CRP could be mediating factors that connect metabolic syndrome and periodontitis.
Development of tularemic scFv antibody fragments using phage display
Authors: Kubelkova Klara , Macela Ales 
Published: April 2010

AbstractPolyclonal antibodies, as well as monoclonal antibodies are efficacious in providing protective immunity against Francisella tularensis. This study demonstrates the application of phage display libraries for the construction of monoclonal antibodies against F. tularensis. Novel single-chain fragment variable (scFv) antibodies were generated against a whole bacterial lysate of F. tularensis live vaccine strain using the human single fold scFv libraries I (Tomlinson I + J). A total of 20 clones reacted with the bacterial cell lysate. Further, the library contains two clones responsive to recombinant lipoprotein FTT1103Δsignal (F. tularensis subsp. tularensis Schu S4), which was constructed without a signal sequence. These positively-binding scFvs were evaluated by scFv-phage enzyme-linked immunosorbent assay (ELISA). Then, positive scFvs were expressed in a soluble form in Escherichia coli HB2151 and tested for positive scFvs by using scFv-ELISA.
Effect of antifungals on itraconazole resistant Candida glabrata
Authors: Kucharíková Soňa , Dijck Patrick , Lisalová Magdaléna , Bujdáková Helena 
Published: April 2010

AbstractIn the last decade, infections caused by Candida glabrata have become more serious, particularly due to its decreased susceptibility to azole derivatives and its ability to form biofilm. Here we studied the resistance profile of 42 C. glabrata clinical isolates to different azoles, amphotericin B and echinocandins. This work was also focused on the ability to form biofilm which plays a role in the development of antifungal resistance. The minimal inhibitory concentration testing to antifungal agents was performed according to the CLSI (Clinical and Laboratory Standards Institute) M27-A3 protocol. Quantification of biofilm was done by XTT reduction assay. All C. glabrata clinical isolates were resistant to itraconazole and sixteen also showed resistance to fluconazole. All isolates remained susceptible to voriconazole. Amphotericin B was efficient in a concentration range of 0.125–1 mg/L. The most effective antifungal agents were micafungin and caspofungin with the MIC100 values of ≤0.0313–0.125 mg/L. Low concentrations of these agents reduced biofilm formation as well. Our results show that resistance of different C. glabrata strains is azole specific and therefore a single azole resistance cannot be assumed to indicate general azole resistance. Echinocandins proved to have very high efficacy against clinical C. glabrata strains including those with ability to form biofilm.
Taxonomical notes on Torymidae (Insecta: Hymenoptera: Chalcidoidea)
Authors: Stojanova Anelia 
Published: April 2010

AbstractAs a result of investigations over type material from a collection of the Hungarian Natural History Museum, Budapest, a new synonym and two new combinations in the Torymidae family (Hymenoptera: Chalcidoidea) are proposed: Eridontomerus illiesi Szelényi, 1981 as a junior synonym of Cryptopristus caliginosus (Walker, 1833); Eridontomerus unidentatus Szelényi, 1973 is transferred to the genus Pseudotorymus Masi, 1921; and Idiomacromerus obscuripennis (Szelényi, 1973) is transferred to the genus Torymoides Walker, 1871.
The Sibyla model and development of beech forests affected by air pollution
Authors: Špulák Ondřej , Souček Jiří 
Published: April 2010

AbstractThe paper deals with the health status, production and structure of autochthonous beech stands in the eastern part of the Krkonoše Mts. (Czech Republic). The region was affected by increased air pollution load due to long-range SO2 transmission from the late 1970s to the early 1990s. In 1980, five research plots were established in long unmanaged beech stands at an optimum stage. Tree coordinates and initial biometrical measurements were made in 1980 and repeated in 2005. The defoliation of individual trees was monitored every year (ICP Forests principles). The actual stand development is compared with the model development worked out by the Sibyla growth simulator in variants with a model of natural mortality and with entering a real mortality of trees. Differences between the stand characteristics of actual and simulated development of forest stands suggest some production losses. The reason to the losses can be seen in the long-term impact of air pollution in the first decade of monitoring and its after-effects on soil quality and worsening health condition of stands. The anticipated acceleration in the onset of the phase of stand disintegration under the influence of air pollution load was not demonstrated.
The Addition of Cervical Thrust Manipulations to a Manual Physical Therapy Approach in Patients Treated for Mechanical Neck Pain: A Secondary Analysis
Authors: Boyles Robert E. , Walker Michael J. , Young Brian A. , Strunce Joseph B. , Wainner Robert S. 
Published: April 2010

Study Design Secondary analysis of a randomized clinical trial (RCT). Objectives To perform a secondary analysis on the treatment arm of a larger RCT to determine differences in treatment outcomes, adverse reactions, and effect sizes between patients who received cervical thrust manipulation and those who received only nonthrust manipulation as part of an impairment-based, multimodal treatment program of manual physical therapy (MPT) and exercise for patients with mechanical neck pain. Background A treatment regimen of MPT and exercise has been effective in patients with mechanical neck pain. Limited research has compared the effectiveness of cervical thrust manipulations and nonthrust mobilizations for this patient population, and no studies have investigated the added benefit of cervical thrust manipulations as part of an overall MPT treatment plan. Methods Treatment outcomes from 47 patients in the treatment arm of a larger RCT, with a primary complaint of mechanical neck pain, were analyzed. Twenty-three patients (49%) received cervical thrust manipulations as part of their MPT treatment, and 24 patients (51%) received only cervical nonthrust mobilizations. All patients received up to 6 clinic sessions, twice weekly for 3 weeks, and a home exercise program. Primary outcome measures were the Neck Disability Index (NDI), 2 visual analog scales for cervical and upper extremity pain, and a 15-point global rating of change scale. Blinded outcome measurements were collected at baseline and at 3-, 6- and 52-week follow-ups. Results Consistent with the larger RCT, both subgroups in this secondary analysis demonstrated improvement in short- and long-term pain and disability scores. Low statistical power (β≤.28) and the resultant small effect size indices (−0.21 to 0.17) preclude the identification of any between-group differences. No serious adverse reactions were reported by patients in either subgroup. Conclusion Clinically meaningful and statistically significant improvements in both subgroups of patients over time suggest that cervical thrust manipulation, as part of the MPT treatment plan, did not influence the results of the treatment arm of the larger RCT from which this study was drawn. Although no between-group differences can be identified, the small observed effect sizes in this study may benefit future studies with sample size estimation for larger RCTs and indicate the need to incorporate clinical prediction rule criteria as a means to improve statistical power. Level of Evidence Therapy, level 4. J Orthop Sports Phys Ther 2010;40(3):133–140. doi:10.2519/jospt.2010.3106
DESIGN OF A NOVEL STENTED VALVE AND 3D MODELING OF ITS IMPLANTATION IN THE AORTA
Authors: Kumar Gideon Praveen , Mathew Lazar 
Published: April 2010

Objective: To design a novel percutaneous stented valve and model its implantation in the aorta.Background: The dimensions of stented aortic valve components govern its ability to prevent backflow of blood into the left ventricle. Whilst the theoretical parameters for the best stent performance have already been established, an effective valve model and its suitability along with the stent are lacking.Methods: This article discusses the design of a stented valve suitable for percutaneous aortic valve replacement. Steps involved in 3D CAD-based geometric modeling of the stented aortic valve and its implantation in the aorta are presented. Conceptual designing of individual components was used to build the total geometric model.Results: A novel geometric model of percutaneous stented aortic valve was generated. The improved design enhances its performance during and after implantation.Conclusion: The blunt hooks in the stent model prevent its migration in either direction by getting embedded in the aortic endothelium. This novel stent aortic valve may be of great interest to designers of future bioprosthetic heart valve models, as well as to surgeons involved in minimally invasive valve surgeries.
Selective Inhibition of JAK1 and JAK2 Is Efficacious in Rodent Models of Arthritis: Preclinical Characterization of INCB028050
Authors: Fridman Jordan S. , Scherle Peggy A. , Collins Robert , Burn Timothy C. , Li Yanlong , Li Jun , Covington Maryanne B. , Thomas Beth , Collier Paul , Favata Margaret F. , Wen Xiaoming , Shi Jack , McGee Ryan , Haley Patrick J. , Shepard Stacey , Rodgers James D. , Yeleswaram Swamy , Hollis Greg , Newton Robert C. , Metcalf Brian , Friedman Steven M. , Vaddi Kris 
Published: April 2010

Abstract
Inhibiting signal transduction induced by inflammatory cytokines offers a new approach for the treatment of autoimmune diseases such as rheumatoid arthritis. Kinase inhibitors have shown promising oral disease-modifying antirheumatic drug potential with efficacy similar to anti-TNF biologics. Direct and indirect inhibition of the JAKs, with small molecule inhibitors like CP-690,550 and INCB018424 or neutralizing Abs, such as the anti-IL6 receptor Ab tocilizumab, have demonstrated rapid and sustained improvement in clinical measures of disease, consistent with their respective preclinical experiments. Therefore, it is of interest to identify optimized JAK inhibitors with unique profiles to maximize therapeutic opportunities. INCB028050 is a selective orally bioavailable JAK1/JAK2 inhibitor with nanomolar potency against JAK1 (5.9 nM) and JAK2 (5.7 nM). INCB028050 inhibits intracellular signaling of multiple proinflammatory cytokines including IL-6 and IL-23 at concentrations &lt;50 nM. Significant efficacy, as assessed by improvements in clinical, histologic and radiographic signs of disease, was achieved in the rat adjuvant arthritis model with doses of INCB028050 providing partial and/or periodic inhibition of JAK1/JAK2 and no inhibition of JAK3. Diminution of inflammatory Th1 and Th17 associated cytokine mRNA levels was observed in the draining lymph nodes of treated rats. INCB028050 was also effective in multiple murine models of arthritis, with no evidence of suppression of humoral immunity or adverse hematologic effects. These data suggest that fractional inhibition of JAK1 and JAK2 is sufficient for significant activity in autoimmune disease models. Clinical evaluation of INCB028050 in RA is ongoing.
Remark on Zero Sets of Holomorphic Functions in Convex Domains of Finite Type
Authors: Jasiczak Michał 
Published: April 2010

AbstractWe prove that if the (1, 1)-current of integration on an analytic subvariety V ⊂ D satisfies the uniform Blaschke condition, then V is the zero set of a holomorphic function ƒ such that log |ƒ| is a function of bounded mean oscillation in bD. The domain D is assumed to be smoothly bounded and of finite d’Angelo type. The proof amounts to non-isotropic estimates for a solution to the -equation for Carleson measures.
Grazing rate of the tintinnid Stenosemella ventricosa (Clap. & Lachm.) Jorg. on the spectrum of the naturally occurring particulate matter from a Mediterranean neritic area1
Authors: Rassoulzadegan Fereidoun , Etienne Michele 
Published: March 2010

Stenosemella ventricosa, a Mediterranean neritic tintinnid, is a consumer of nanoplankton. It feeds on particles with diameters from 1.3 to 27 µm and more intensively on particles in the 3–12‐µm range. After being acclimated for 24 h without food, S. ventricosa exhibits a very high feeding rate on a population of natural particles during the first few hours: 4 × 105 µm3 (wet vol food)·tintinnid−1·d−1. The rate decreases at about 20 h and stabilizes around a mean value of 4.6 × 104 µm3. The stabilized rate is equal to 66% of the fresh weight of the tintinnid (7 × 104 µm3), or 43% (0.0024 µg C·tintinnid−1·d1) of its body organic carbon (about 0.0056 µg).The ingestion rate of S. ventricosa feeding on particles between 1.3 and 27 µm seems to be a function of particle concentration. Significant correlations (at 0.01 or 0.05 level) were observed between ingestion rate per size class and particulate food concentration within each class. After feeding in some size range for a certain period, S. ventricosa seems to be able to switch its feeding pressure to particles in other size categories which have not yet been consumed.
Spatial distributions of pollen in surface sediments of the Potomac estuary1
Authors: Brush Grace S. , DeFries Ruth S. 
Published: March 2010

Pollen of trees extracted from surface sediments of the Potomac estuary represent all components of the arboreal vegetation, with the exception of Liriodendron tulipifera (tulip poplar), and reflect the major forest gradients in a broad band adjacent to the estuary. Pollen of common trees restricted to the upper watershed, 60 km upstream of the limit of tidal influence, are not present in downstream estuarine deposits.A comparison of the statistical variability in pollen data from estuarine sediments with tree data in the area adjacent to the estuary suggests that atmospheric or estuarine transport processes erase the local patchiness of the trees from the pollen distributions in the sediment. Although dispersion is selective for different pollen types, none of the pollen is transported far enough to mask regional forest gradients.Pollen distributions in Potomac estuary sediments suggest that once particles of approximate hydraulic equivalence become part of the suspended sediment load, they are not widely dispersed within the estuary before initial deposition.
Production ecology of Cricotopus sylvestris (Fabricius) (Diptera: Chironomidae) in a shallow estuarine cove
Authors: Menzie Charles A. 
Published: March 2010

Cricotopus sylvestris was the predominant chironomid (80% composition by abundance) living on Myriophyllum spicatum in a cove of the Hudson River estuary. Annual production of C. sylvestris was conservatively estimated by the size‐frequency method to be 5.8 g·m‒2·yr‒1 (dry weight).The annual (P:B) ratio for the species was 21.0, one of the highest values reported for chironomids. Laboratory‐reared larvae completed development in 10 days at 22° and 29°C and 28 days at 15°C, while development in the field was conservatively estimated to take 42 days. Production of C. sylvestris accounted for 31% of total chironomid production in the cove and 60% of the production of chironomid species associated with M. spicutum. The biomass of emerged adults of C. sylvestris was estimated to be 2 g·m‒2·yr‒1, or 34% of the produced larval biomass. Cage experiments in the field and laboratory studies of feeding rates indicated that damselfly naiads consumed much of the larval biomass not removed by adult emergence. The larvae also were eaten by other invertebrates and fish.
Properties of the seawater‐air interface. 2. Rates of surface film formation under steady state conditions1
Authors: Dragcevic Dj. , Pravdic V. 
Published: March 2010

The laboratory techniques of dynamic surface tension and of surface electrical potential measurements were used to determine rates of formation and of reorientation of organic surface films at the seawater‐air interface. Relaxation times of surface films were determined for three characteristic samples obtained by screen and bottle sampling in the coastal waters of the northern Adriatic area. These data were compared with those for model samples produced by spreading oleic acid and crude oil on or dissolving polyethyleneglycol and sodium dodecyl sulfate in artificial seawater.Relaxation times were in the range of 0.1–1 s for most of samples. A good representative value for field samples is 0.2 s. The temperature‐dependence (the energies of activation) for the surface film relaxation indicates that several processes control material transport toward the seawater‐air interface.The findings are interpreted as showing that an almost ever‐present organic surface film influences the mechanism and the rate of material transport across the sea‐atmosphere boundary.
Chemistry of interstitial water and bottom sediments as indicators of seepage patterns in Perch Lake, Chalk River, Ontario1
Authors: Frape S. K. , Patterson R. J. 
Published: March 2010

A coring and squeezing technique was used to study seepage processes in Perch Lake. This lake was selected because a portion of the shallow aquifer in its basin contains tritium, which is an excellent tracer. Tritium analyses of interstitial water samples and well waters from piezometers adjacent to the lake indicate a pattern of groundwater discharge, or seepage, consistent with the predictions of mathematical simulations. Shallow groundwaters in the aquifer discharge almost vertically into the lake near the shore; water deeper in the aquifer enters the lake farther from shore. As a result of this groundwater discharge, metals such as iron and manganese are being deposited in the sediments.Interstitial waters in Perch Lake, especially nearshore, are groundwaters or groundwaters mixed with lake waters. The chemistry of interstitial waters in lake sediments may thus be determined by the quality of local groundwaters as well as by sediment‐water reactions and vertical diffusional mixing. Data from nests of piezometers near the lake and from cores or multilevel piezometers in the lake bottom, information about bottom sediments, and measurements of seepage flux will be needed to estimate the contributions to lakes of dissolved components from groundwater discharge.