bluuebunny/crossref_metadata_2025_split huggingface dataset:
An investigation of weight suppression in a population‐based sample of female twins
Authors: Mitchell Karen S. , Neale Michael C. , Bulik Cynthia M. , Lowe Michael , Maes Hermine H. , Kendler Kenneth S. , Mazzeo Suzanne E. 
Published: January 2010

AbstractObjective:Weight suppression (WS), maintaining a body weight below one's maximum adult weight, is associated with bingeing, purging, and weight gain in clinical samples.Method:We investigated associations between eating disorder‐related variables and WS and additive genetic (A), common (C), and unique (E) environmental contributions to WS in a population‐based sample of 1,503 female adult twins.Results:Modeling results were similar for participants reporting no binge eating (NBE) and those reporting binge eating plus loss of control (BE + LOC): 20–25% of the variance in WS was due to A and 70–75% due to E. Among NBE participants, restraint, drive for thinness, body dissatisfaction, and dieting during child/adulthood were related to WS. Restraint, disinhibition, and dieting during childhood were significantly associated with WS in the BE + LOC subsample.Discussion:Although maintaining lower body weight could be advantageous, interventionists should take care when addressing weight suppression in individuals vulnerable to eating disorder symptomatology. © 2010 by Wiley Periodicals, Inc. (Int J Eat Disord 2011; 44:44–49)
The effectiveness of a day program for the treatment of adolescent anorexia nervosa
Authors: Goldstein Mandy , Peters Lorna , Baillie Andrew , McVeagh Patricia , Minshall Gerri , Fitzjames Dianne 
Published: January 2010

AbstractObjective:The risks of anorexia nervosa (AN) are well established. Despite its severity, little certainty exists for practitioners, with ethical and financial limitations yielding few controlled studies establishing effective treatments. Thus, other methods of establishing treatment effectiveness are necessary. This study presents preliminary results of an open clinical trial of a day program for adolescents with AN.Method:Participants were 26 anorectic females, 12–18 years, who completed the “Transition Program.”Results:Significant change emerged on measures of weight gain, and behavioral and attitudinal measures of eating pathology. Large effect sizes were evident for weight gain at 6 month follow‐up. Preliminary trends suggest that treatment gains on these and other measures of eating pathology were maintained at 6 month follow‐up.Discussion:Preliminary results support day program treatment for adolescents with mild‐moderately severe eating disorders. Present outcomes are discussed with respect to the dearth of efficacious treatment options for adolescents. © 2010 by Wiley Periodicals, Inc. (Int J Eat Disord 2011; 44:29–38)
Feeding and eating disorders in childhood
Authors: Bryant‐Waugh Rachel , Markham Laura , Kreipe Richard E. , Walsh B. Timothy 
Published: January 2010

AbstractObjective:To review the literature related to the current DSM‐IV‐TR diagnostic criteria for feeding disorder of infancy or early childhood; pica; rumination disorder; and other childhood presentations that are characterized by avoidance of food or restricted food intake, with the purpose of informing options for DSM‐V.Method:Articles were identified by computerized and manual searches and reviewed to evaluate the evidence supporting possible options for revision of criteria.Results:The study of childhood feeding and eating disturbances has been hampered by inconsistencies in classification and use of terminology. Greater clarity around subtypes of feeding and eating problems in children would benefit clinicians and patients alike.Discussion:A number of suggestions supported by existing evidence are made that provide clearer descriptions of subtypes to improve clinical utility and to promote research. © 2010 American Psychiatric Association. (Int J Eat Disord 2010)
Syntheses, Crystal Structures and Gas Sorption Properties of Prussian Blue Analogues Constructed from [Cr(CN)6]3– Building Blocks
Authors: Yuan Ai‐Hua , Chu Chao‐Xia , Zhou Hu , Yuan Peng , Liu Kang‐Kang , Li Li , Zhang Qing‐Feng , Chen Xin , Li Yi‐Zhi 
Published: January 2010

AbstractThree isostructural porous Prussian blue analogues KM[Cr(CN)6]·H2O (M = Zn, Mn, Fe) with alkali metal cations K+ located within the pores of the frameworks have been constructed and characterized structurally. Thermal gravimetric analysis and variable‐temperature powder XRD results indicate that the three porous materials are stable at high temperatures, and their frameworks are still retained after dehydration. The permanent porosities have been confirmed by nitrogen and hydrogen sorption measurements at 77 K. Sorption studies show that the framework of FeCr with just 289 m2 g–1 BET surface area can take up a moderate amount of H2 at 77 K and 860 Torr [112 cm3(STP) g–1, 0.71 wt.‐%], which indicates that the guest alkali metal cation K+ located in the pores can enhance the H2 binding affinity within the dehydrated porous framework.
PCR, sequencing and PCR–RFLP of the 5S‐rRNA‐NTS region as a tool for the DNA fingerprinting of medicinal and aromatic plants
Authors: Gnavi Giorgio , Bertea Cinzia M. , Maffei Massimo E. 
Published: January 2010

AbstractMolecular genetic methods have several advantages over classical morphological and chemical analyses. For instance, the genetic method requires genotype instead of phenotype, therefore DNA‐based techniques have been widely used for rapid identification of herbal medicine and aromatic plants. Using PCR approaches, nanogram quantities of DNA are required to amplify and yield sufficient amounts of template DNA for molecular genetic analysis. Recently, the molecular discrimination of some higher plant species has been evaluated using sequences of a 5S‐rRNA gene spacer region. The variation in the non‐transcribed sequence (NTS) region has been used in a number of plant species for studying intraspecific variation, mapping 5S rDNA arrays, genome evolution and phylogenetic reconstruction. In this minireview we summarize the potential use of the 5S‐rRNA‐NTS region as a tool for the DNA fingerprinting of medicinal and aromatic plants. Copyright © 2010 John Wiley & Sons, Ltd.
Common and distinct neural substrates for the perception of speech rhythm and intonation
Authors: Zhang Linjun , Shu Hua , Zhou Fengying , Wang Xiaoyi , Li Ping 
Published: January 2010

AbstractThe present study examines the neural substrates for the perception of speech rhythm and intonation. Subjects listened passively to synthesized speech stimuli that contained no semantic and phonological information, in three conditions: (1) continuous speech stimuli with fixed syllable duration and fundamental frequency in the standard condition, (2) stimuli with varying vocalic durations of syllables in the speech rhythm condition, and (3) stimuli with varying fundamental frequency in the intonation condition. Compared to the standard condition, speech rhythm activated the right middle superior temporal gyrus (mSTG), whereas intonation activated the bilateral superior temporal gyrus and sulcus (STG/STS) and the right posterior STS. Conjunction analysis further revealed that rhythm and intonation activated a common area in the right mSTG but compared to speech rhythm, intonation elicited additional activations in the right anterior STS. Findings from the current study reveal that the right mSTG plays an important role in prosodic processing. Implications of our findings are discussed with respect to neurocognitive theories of auditory processing. Hum Brain Mapp, 2010. © 2009 Wiley‐Liss, Inc.
The role of the cingulate cortex as neural generator of the N200 and P300 in a tactile response inhibition task
Authors: Huster R.J. , Westerhausen R. , Pantev C. , Konrad C. 
Published: January 2010

AbstractBoth the N200 and P300, which are, for example, evoked by Go/Nogo or Stop‐Signal tasks, have long been interpreted as indicators for inhibition processes. Such interpretations have recently been challenged, and interest in the exact neural generators of these brain responses is continuously growing. Using recent methodological advancements, source estimations for the N200 and P300 as evoked by a tactile response inhibition task were computed. Current density reconstructions were also calculated accounting for interindividual differences in head geometry by incorporating information from T1‐weighted magnetic resonance images. To ease comparability with relevant paradigms, the task was designed to mimic important characteristics of both Go/Nogo and Stop‐Signal tasks as prototypes for a larger set of paradigms probing response inhibition. A network of neural generators was revealed, which has previously been shown to act in concert with executive control processes and thus is in full agreement with observations from other modalities. Importantly, a spatial segregation of midcingulate sources was observed. Our experimental data indicate that a left anterior region of the midcingulate cortex (MCC) is a major neural generator of the N200, whereas the midcingulate generator of the P300 is located in the right posterior MCC. Analyses of the P300 also revealed several areas, which have previously been associated with motor functions, for example, the precentral region. Our data clearly suggest a neuroanatomical and therefore also functional dissociation of the N200 and P300, a finding that cannot easily be provided by other imaging techniques. Hum Brain Mapp, 2010. © 2010 Wiley‐Liss, Inc.
Assessing damaged road verges as a suspended sediment source in the Hampshire Avon catchment, southern United Kingdom
Authors: Collins A. L. , Walling D. E. , Stroud R. W. , Robson M. , Peet L. M. 
Published: January 2010

AbstractDiffuse sediment pollution impairs water quality, exerts a key control on the transfer and fate of nutrients and contaminants and causes deleterious impacts on freshwater ecology. A variety of catchment sediment sources can contribute to such problems. Sediment control strategies and effective targeting of mitigation options therefore require robust quantitative information on the key sources of the sediment problem at catchment scale. Recent observations by Catchment Sensitive Farming Officers (CSFO's) in England have highlighted road verges damaged and eroded by passing vehicles, particularly large farm machinery, and livestock herd movement as visually important potential sources of local sediment problems. A study was therefore undertaken to assess the relative importance of damaged road verges as a suspended sediment source in three sub‐catchments of the Hampshire Avon drainage basin, southern UK. Road verge sediment contributions were apportioned in conjunction with those from agricultural topsoils and channel banks/subsurface sources. Time‐integrating isokinetic samplers were deployed to sample suspended sediment fluxes at the outlets of two control sub‐catchments drained by the Rivers Chitterne and Till selected to characterize areas with a low road network density and limited visual evidence of verge damage, as well as the River Sem sub‐catchment used to represent areas where road verge damage is more prevalent. The findings of a sediment source fingerprinting investigation based on a combination of intermittent sampling campaigns spanning the period 22/5/02–27/4/08 suggested that the respective overall mean relative sediment contributions from damaged road verges were 5 ± 3%, 4 ± 2% and 20 ± 2%. Relative inputs from damaged road verges for any specific sampling period in the River Sem sub‐catchment were as high as 33 ± 2%. Reconstruction of historical sources in the same sub‐catchment, based on the geochemical record stored in a floodplain depth profile, suggested that the significance of damaged road verges as a sediment source has increased over the past 15–20 years. The findings provide important information on damaged road verges as a primary source of suspended sediment and imply that catchment sediment control strategies and mitigation plans should consider such verges in addition to those agricultural and channel sources traditionally taken into account when attempting to reduce sediment pressures on aquatic resources. Copyright © 2010 John Wiley & Sons, Ltd.
Controls on snowmelt water mean transit times in northern boreal catchments
Authors: Lyon Steve W. , Laudon Hjalmar , Seibert Jan , Mörth Magnus , Tetzlaff Doerthe , Bishop Kevin H. 
Published: January 2010

AbstractCatchment‐scale transit times for water are increasingly being recognized as an important control on geochemical processes. In this study, snowmelt water mean transit times (MTTs) were estimated for the 15 Krycklan research catchments in northern boreal Sweden. The snowmelt water MTTs were assumed to be representative of the catchment‐scale hydrologic response during the spring thaw period and, as such, may be considered to be a component of the catchment's overall MTT. These snowmelt water MTTs were empirically related to catchment characteristics and landscape structure represented by using different indices of soil cover, topography and catchment similarity. Mire wetlands were shown to be significantly correlated to snowmelt MTTs for the studied catchments. In these wetlands, shallow ice layers form that have been shown to serve as impervious boundaries to vertical infiltration during snowmelt periods and, thus, alter the flow pathways of water in the landscape. Using a simple thought experiment, we could estimate the potential effect of thawing of ice layers on snowmelt hydrologic response using the empirical relationship between landscape structure (represented using a catchment‐scale Pe number) and hydrologic response. The result of this thought experiment was that there could be a potential increase of 20–45% in catchment snowmelt water MTTs for the Krycklan experimental catchments. It is therefore possible that climatic changes present competing influences on the hydrologic response of northern boreal catchments that need to be considered. For example, MTTs may tend to decrease during some times of the year due to an acceleration in the hydrologic cycle, while they tend to increase MTTs during other times of the year due to shifts in hydrologic flow pathways. The balance between the competing influences on a catchment's MTT has consequences on climatic feedbacks as it could influence hydrological and biogeochemical cycles at the catchment scale for northern latitude boreal catchments. Copyright © 2010 John Wiley & Sons, Ltd.
Identification of SPARC as a candidate target antigen for immunotherapy of various cancers
Authors: Inoue Mitsuhiro , Senju Satoru , Hirata Shinya , Ikuta Yoshiaki , Hayashida Yuki , Irie Atsushi , Harao Michiko , Imai Katsunori , Tomita Yusuke , Tsunoda Takuya , Furukawa Yoichi , Ito Takaaki , Nakamura Yusuke , Baba Hideo , Nishimura Yasuharu 
Published: January 2010

AbstractTo establish efficient anticancer immunotherary, it is important to identify tumor‐associated antigens (TAAs) directing the immune system to attack cancer. A genome‐wide cDNA microarray analysis identified that secreted protein acidic and rich in cysteine (SPARC) gene is overexpressed in the gastric, pancreatic and colorectal cancer tissues but not in their noncancerous counterparts. This study attempted to identify HLA‐A24 (A*2402)‐restricted and SPARC‐derived CTL epitopes. We previously identified H‐2Kd‐restricted and SPARC‐derived CTL epitope peptides in BALB/c mice, of which H‐2Kd‐binding peptide motif is comparable with that of HLA‐A24 binding peptides. By using these peptides, we tried to induce HLA‐A24 (A*2402)‐restricted and SPARC‐reactive human CTLs and demonstrated an antitumor immune response. The SPARC‐A24‐1143–151 (DYIGPCKYI) and SPARC‐A24‐4225–234 (MYIFPVHWQF) peptides‐reactive CTLs were successfully induced from peripheral blood mononuclear cells by in vitro stimulation with these two peptides in HLA‐A24 (A*2402) positive healthy donors and cancer patients, and these CTLs exhibited cytotoxicity specific to cancer cells expressing both SPARC and HLA‐A24 (A*2402). Furthermore, the adoptive transfer of the SPARC‐specific CTLs could inhibit the tumor growth in nonobese diabetic/severe combined immunodeficient mice bearing human cancer cells expressing both HLA‐A24 (A*2402) and SPARC. These findings suggest that SPARC is a potentially useful target candidate for cancer immunotherapy.
Assessment of linear finite‐difference Poisson–Boltzmann solvers
Authors: Wang Jun , Luo Ray 
Published: January 2010

AbstractCPU time and memory usage are two vital issues that any numerical solvers for the Poisson–Boltzmann equation have to face in biomolecular applications. In this study, we systematically analyzed the CPU time and memory usage of five commonly used finite‐difference solvers with a large and diversified set of biomolecular structures. Our comparative analysis shows that modified incomplete Cholesky conjugate gradient and geometric multigrid are the most efficient in the diversified test set. For the two efficient solvers, our test shows that their CPU times increase approximately linearly with the numbers of grids. Their CPU times also increase almost linearly with the negative logarithm of the convergence criterion at very similar rate. Our comparison further shows that geometric multigrid performs better in the large set of tested biomolecules. However, modified incomplete Cholesky conjugate gradient is superior to geometric multigrid in molecular dynamics simulations of tested molecules. We also investigated other significant components in numerical solutions of the Poisson–Boltzmann equation. It turns out that the time‐limiting step is the free boundary condition setup for the linear systems for the selected proteins if the electrostatic focusing is not used. Thus, development of future numerical solvers for the Poisson–Boltzmann equation should balance all aspects of the numerical procedures in realistic biomolecular applications. © 2010 Wiley Periodicals, Inc. J Comput Chem, 2010
The synthesis and characterization of solvatochromic maleimide‐fused N‐allyl‐ and N‐alkyl‐substituted 1,4‐dithiines and Diels–Alder reactions with anthracene
Authors: Gülten Şirin 
Published: January 2010

Abstract
magnified imageA simple and facile access to new solvatochromic maleimide‐fused N‐allyl‐ and N‐alkyl‐substituted 1,4‐dithiines from the corresponding N‐substituted succinamic acid derivatives in one‐pot with oxidation by thionyl chloride is described. The Diels–Alder reaction of these 1,4‐dithiines with anthracene has been investigated. The 1,4‐dithiine derivatives react smoothly with anthracene via charge‐transfer complexes to form the Diels–Alder adducts in excellent yields. J. Heterocyclic Chem., (2010).
Solvent‐dependent fluorescence emission in heterocyclic compounds having isoquinoline backbone
Authors: Singh Devendra , Ghosh Subrata Kumar , Baruah Jubaraj B. 
Published: January 2010

Abstract
magnified imageFew amino derivatives of benzo[de]benzo[4,5]imidazo[2,1‐a]isoquinolin‐7‐one having amino groups at different positions of the rings are prepared and characterized. Solvent‐dependent emission and changes in emission properties on protonation of amine group are observed. J. Heterocyclic Chem., (2010).
Nephrogenic systemic fibrosis: What the hospitalist needs to know
Authors: Fine Derek M. , Perazella Mark A. 
Published: January 2010

AbstractNephrogenic systemic fibrosis (NSF) has now been linked to gadolinium‐based contrast (GBC) exposure in those with compromised kidney function, particularly those with end‐stage renal disease (ESRD). When ESRD is present, symptoms can be quite devastating for the patient including severe pain and immobility and even death. For those at risk, avoidance of GBC exposure, whenever possible, is absolutely essential to prevent this potentially devastating complication. Identifying those at risk depends in some circumstances on appropriate recognition of renal dysfunction and understanding appropriate use of glomerular filtration rate (GFR) estimation formulas. Although hemodialysis (but not peritoneal dialysis) removes gadolinium, the availability of dialysis should never be used as a justification for GBC use in this high‐risk population. Unfortunately there is a lack of a universally effective therapy. Resolution of acute kidney injury (AKI) appears to attenuate disease in most cases, while kidney transplantation has been associated with variable success. Journal of Hospital Medicine 2010;5:46–50. © 2010 Society of Hospital Medicine.
Characteristics of intensive care units in Michigan: Not an open and closed case
Authors: Hyzy Robert C. , Flanders Scott A. , Pronovost Peter J. , Berenholtz Sean M. , Watson Sam , George Chris , Goeschel Christine A. , Maselli Judith , Auerbach Andrew D. 
Published: January 2010

AbstractOBJECTIVE:Delivery of critical care by intensivists has been recommended by several groups. Our objective was to understand the delivery of critical care physician services in Michigan and the role of intensivists and nonintensivist providers in providing care.DESIGN:Descriptive questionnaire.PARTICIPANTS AND SETTING:Intensive care unit (ICU) directors and nurse managers at 96 sites, representing 115 ICUs from 72 hospitals in Michigan.MEASUREMENTS AND RESULTS:The primary outcome measure was the percentage of sites utilizing a closed vs. an open model of ICU care. Secondary outcome measures included the percentage of ICUs utilizing a high‐intensity service model, hospital size, ICU size, type of clinician providing care, and clinical activities performed. Twenty‐four (25%) sites used a closed model of intensive care, while 72 (75%) had an open model of care. Hospitals with closed ICUs were larger and had larger ICUs than sites with open ICUs (P < 0.05). Hospitalists serving as attending physicians were strongly associated with an open ICU (odds ratio [OR] = 12.2; 95% confidence interval [CI] = 2.5‐60.2), as was the absence of intensivists in the group (OR = 12.2; 95%CI = 1.4‐105.8), while ICU and hospital size were not associated. At 18 sites (20%) all attendings were board certified in Critical Care. Sixty sites had less than 50% board‐certified attending physicians.CONCLUSIONS:The closed intensivist‐led model of intensive care delivery is not in widespread use in Michigan. In the absence of intensivists, alternate models of care, including the hospitalist model, are frequently used. Journal of Hospital Medicine 2010;5:4–9. © 2010 Society of Hospital Medicine.
Solution structure of the C‐terminal X domain of the measles virus phosphoprotein and interaction with the intrinsically disordered C‐terminal domain of the nucleoprotein
Authors: Gely Stéphane , Lowry David F. , Bernard Cédric , Jensen Malene R. , Blackledge Martin , Costanzo Stéphanie , Bourhis Jean‐Marie , Darbon Hervé , Daughdrill Gary , Longhi Sonia 
Published: January 2010

AbstractIn this report, the solution structure of the nucleocapsid‐binding domain of the measles virus phosphoprotein (XD, aa 459–507) is described. A dynamic description of the interaction between XD and the disordered C‐terminal domain of the nucleocapsid protein, (NTAIL, aa 401–525), is also presented. XD is an all α protein consisting of a three‐helix bundle with an up‐down‐up arrangement of the helices. The solution structure of XD is very similar to the crystal structures of both the free and bound form of XD. One exception is the presence of a highly dynamic loop encompassing XD residues 489–491, which is involved in the embedding of the α‐helical XD‐binding region of NTAIL. Secondary chemical shift values for full‐length NTAIL were used to define the precise boundaries of a transient helical segment that coincides with the XD‐binding domain, thus shedding light on the pre‐recognition state of NTAIL. Titration experiments with unlabeled XD showed that the transient α‐helical conformation of NTAIL is stabilized upon binding. Lineshape analysis of NMR resonances revealed that residues 483–506 of NTAIL are in intermediate exchange with XD, while the 475–482 and 507–525 regions are in fast exchange. The NTAIL resonance behavior in the titration experiments is consistent with a complex binding model with more than two states. Copyright © 2010 John Wiley & Sons, Ltd.