bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bilateral Glaucoma Drainage Device (GDD) Implantation in Steroid Induced Glaucoma
Authors: Suparta Putu Gede Yudi Darma Wijaya , I Gusti Ayu Ratna Suryaningrum  , I Made Agus Kusumadjaja  
Published: May 2024

Objective: This study aims to report a case of Bilateral Glaucoma Drainage Device (GDD) implantation surgery in a patient with Steroid Induced Glaucoma.
Case Presentation: A 18-year-old male patient with steroid-induced glaucoma and allergic conjunctivitis. The patient also complained about red eyes and itchy in both eyes and had been using steroid eye drops for 5 years. The patient also complained about headaches and blurry vision. The patient had undergone trabeculectomy surgery 5 months ago on the left eye. The visual acuity was 6/6 on the right eye and 6/7.5 on the left eye. His intraocular pressure (IOP) on the right eye was 24 mmHg, and his left eye was 23 mmHg with conjunctival left eye bleb, flat, and fibrosis. The patient then underwent a non-valve Virna’s GDD implant surgery on the right eye. On day two post-GDD, the IOP was 4 mmHg, and the COA was shallow, so reform the COA. At the first month follow-up, the patient's right eye pressure was still in normal condition with no complications, and then the plan was for left eye Virna’s GDD implantation surgery. At the first month follow-up after left eye GDD implantation, the visual acuity was 6/9 on the right eye and 6/24 on the left eye, with IOP RE 11mmHg and LE 16mmHg, from anterior segment deep anterior chamber, no plate exposed, no leakage, and tube not attached to the corneal endothelium. The patient's intraocular pressure was still in normal condition in both eyes, and no complications was found, although the patient was still using low-dose topical steroid eye drops.
Conclusion: In steroid-induced glaucoma, after trabeculectomy failure, the implantation of GDD is the most effective option in controlling high IOP and slowing down glaucoma progressivity.
Developing scriptural agency through participatory action research embedded in service learning
Authors: Jaffer Saleemah , Bayat Abdullah 
Published: May 2024

The paper reports on students at an Islamic higher education institute in South Africa who were enrolled in a service learning module to see whether this led to augmentation in their agency. In the service learning (SL) module, the students were tasked with using community-based participatory action research (CBPAR) which enabled them to make reflective decisions which is the basis of their augmented agency. The research method was a self-study case study. Implications for religious institutions is that they are encouraged to include service learning in their curriculum. The implication for students is that learning faith is about living the faith in context. Lecturers need to shift their pedagogy and teach the faith in an applied manner beyond traditional rote learning. Pedagogic insights included the important role of self-reflection and the activation of student agency through community engagement. Students found participating with community members empowering. Students enjoyed the experience and found the opportunity to transfer scripture into service learning invaluable. They realised their ability to make a change, lived their scripture, and the community benefited from this. Artikel ini menjelaskan tentang mahasiswa di sebuah lembaga pendidikan tinggi keislaman di Afrika Selatan yang mengikuti modul pembelajaran pengabdian untuk melihat apakah hal ini dapat meningkatkan kepemimpinan mereka. Dalam modul pembelajaran pengabdian/service learning (SL), para mahasiswa ditugaskan untuk menggunakan penelitian tindakan partisipatif berbasis masyarakat (CBPAR) yang memungkinkan mereka untuk membuat keputusan reflektif yang merupakan dasar bagi peningkatan kepemimpinan mereka. Metode penelitian yang digunakan adalah studi kasus belajar mandiri. Implikasi riset ini bagi lembaga keagamaan adalah bahwa mereka didorong untuk memasukkan pembelajaran pengabdian dalam kurikulum mereka. Implikasi bagi mahasiswa adalah belajar tentang iman berarti bagaimana mengamalkan iman dalam keseharian. Para dosen perlu mengubah pengajaran mereka dan mengajarkan iman dengan cara yang lebih dari sekadar hafalan. Wawasan pedagogis termasuk peran penting dari refleksi diri dan aktivasi kepemimpinan mahasiswa melalui keterlibatan masyarakat. Para mahasiswa merasa bahwa berpartisipasi dengan anggota masyarakat sangat memberdayakan. Mereka menikmati pengalaman ini dan menemukan bahwa kesempatan untuk mengamalkan kitab sucinya ke dalam pembelajaran pengabdian sangat berharga. Mereka menyadari kemampuan mereka untuk membuat perubahan, menghayati kitab suci, dan masyarakat mendapat manfaat dari hal ini.
Multicultural education in perspective Islamic educational science
Authors: Sholihah Lilis , Kurniasih Nia , Sahliah Sahliah , Erihadiana Mohamad 
Published: May 2024

This research aims to examine multicultural education from the perspective of Islamic Education Science by identifying multicultural values in Islam and chlorinating challenges and obstacles in realizing multicultural education in the Islamic context. The research method used is qualitative with a library research approach. The results showed that multicultural education from an Islamic perspective is by integrating multicultural values into Islamic religious learning and the focus is on developing attitudes and behaviors that respect cultural, religious, and ethnic diversity and of course by involving the development of character, knowledge, and attitudes by Islamic teachings. The challenges and obstacles in realizing multicultural education in the Islamic context are the difficulty of building a strong perception and awareness of the importance of multicultural education in Islamic societies, the existence of several traditions and cultures in Islamic societies emphasizing homogeneity, and resisting change or outside influences. Finally, the development of curricula and teaching methods that conform to multicultural principles in the Islamic context requires profound adjustment. Penelitian ini bertujuan mengkaji secara mendalam tentang pendidikan multikultural dari perspektif Ilmu Pendidikan Islam dengan mengidentifikasi nilai –nilai multicultural dalam Islam dan mengeklorasi tantangan dan hambatan dalam mewujudkan pendidikan multicultural dalam konteks Islam. Metode penelitian yang digunakan adalah kualitatif dengan pendekatan library research. Hasil penelitian menunjukkan bahwa pendidikan multikultural dalam persfektif Islam yaitu dengan mengintegrasikan nilai-nilai multikultural dalam pembelajaran agama Islam dan fokusnya adalah pada pengembangan sikap dan perilaku yang menghargai keragaman budaya, agama, dan etnis dan tentunya dengan melibatkan pengembangan karakter , pengetahuan, dan sikap yang sesuai dengan ajaran Islam. Adapun yang menjadi tantangan dan hambatan dalam mewujudkan pendidikan multicultural dalam kontek Islam adalah sulitnya membangun persepsi dan kesadaran yang kuat tentang pentingnya pendidikan multikultural dalam masyarakat Islam,adanya beberapa tradisi dan budaya dalam masyarakat Islam menekankan pada homogenitas dan menolak perubahan atau pengaruh luar. Dan terkahir pengembangan kurikulum dan metode pengajaran yang sesuai dengan prinsip-prinsip multikultural dalam konteks Islam memerlukan penyesuaian yang mendalam.
The concept of thinking and dzikir as an Islamic education process
Authors: Kusuma Deni Tata , Hambali Adang , Suhartini Andewi 
Published: May 2024

Education is currently experiencing changes that are far from instilling religious values, so there is a need for a dhikr approach in educating students and not just focusing on thinking. The purpose of this research is to find out the potential between thinking and remembrance and its implications in Islamic education. This article uses a qualitative approach by taking books, journals, newspapers and others according to the title and material discussed. From these problems it can be concluded that by combining Islamic education from thinking and remembrance it will produce humans who are always strong from the outside and strong from within as well, strong from the outside, one of which is physically, emotionally, can make decisions correctly and is strong from within, namely his relationship with Allah Almighty being more harmonious in carrying out any activity cannot be separated from remembering Allah SWT. Pendidikan islam pada zaman ini telah mengalami penurunan nilai-nilai agama yang begitu jauh, siswa semakin kurang dari sisi spiritualnya, sehingga perlu dan harus adanya perubahan, salah satu pendekatannya dengan membersihkan hati kembali kepada Allah Swt. dengan cara berzikir membuka pikiran terhadap nilai-nilai agama. Tujuan penelitian ini diharapkan menjadikan siswa lebih dekat kepada Allah Swt. dan menjadi siswa yang berkualitas bukan kuantitas. Artikel ini menggunakan metode kualitatif dengan mengambil dari buku, jurnal, koran dan lainnya yang sesuai dengan judul dan materi yang dibahas. Dari hasil penemuan berbagai litertatur bahwa berfikit dan dzikir memiliki kesinanbungan dalam memperbaiki jasmani dan rohani siswa yang nantinya akan memiliki rasa empati, berakhlak mulia, berkata dengan sopan santun. Simpulannya dalam hal ini bahwasanya dengan menggabungkan pendidikan Islam dari pikir dan zikir akan menghasilkan manusia yang senantiasa kuat dari luar dan kuat dari dalam pula, kuat dari luar salah satunya fisik, emosional, dapat mengambil keputusan dengan tepat dan kuat dari dalam yaitu hubungan siswa dengan Allah Swt. semakin harmonis dalam melakukan aktivitas apapun tidak lepas dari mengingat Allah Swt.
Debottlenecking of FPSO by Using Compact Solution and Optimizing the Surface Facility of Unmanned Well Head Platform
Authors: Jakkulwar Avi Diliprao , Joshi N. B. , Sengupta Partha , Rahul R. , Nischal Rajiv 
Published: May 2024

Production from mature fields are decline so in this scenario Oil companies are trying to develop all its resources. Here in ONGC we are trying to develop marginal field which is difficult to sustain on their own, hence we have clubbed these fields as a cluster and we hired the FPSO to process this well fluid to separate oil gas and water.
The FPSO is deployed to take the production from the cluster, due to the addition, expansion and development of marginal fields to cluster, the production has increased. The increased gas feed is creating problems of surges, intermittent flaring and carryover of liquid and causing bottleneck to the FPSO. Debottlenecking of FPSO through novel approach of optimizing the surface facility of Unmanned Well Head Platform was done.
Well fluid from A-1, A-2, A-3, A-4 platforms of cluster II and B-2, B-2-1, B-2-1, B-2-2-2 platforms of cluster III is received at (AB2) unmanned platform and further routed to FPSO.
HDAC3 inhibitor RGFP966 mitigates acute kidney injury by modulating RIPK1-mediated programmed necrosis
Authors: Chen Qi , Chen Qi , xie man-man , xie man-man , Chen Ying , Chen Ying , shan run-run , shan run-run , yu ju-tao , yu ju-tao , hou rui , hou rui , dong yu-hang , dong yu-hang , luo xiu-feng , luo xiu-feng , Dong Ze-hui , Dong Ze-hui , gao li , gao li , Meng Xiao-ming , Meng Xiao-ming , zhang shao-fei , zhang shao-fei 
Published: May 2024

Abstract

Acute kidney injury (AKI) refers to clinical syndromes culminating in sharp reduction in renal function over a short period of time because of various reasons. These syndromes manifest in the form of inflammation and apoptosis of renal tubular epithelial cells via controlled demise. Histone deacetylases are critical in renal physiology and fibrosis. Here, the HDAC3 expression was shown to be upregulated and localized predominantly in the renal tubules in an AKI mouse model. Moreover, the selective HDAC3 inhibitor RGFP966 was found to reduce inflammation and injury caused by cisplatin and hypoxia–reoxygenation in HK2 cells. Importantly, RGFP966 exerted potent protective effects in mouse models of ischemia/reperfusion-induced AKI and cisplatin. Furthermore, RNA sequencing revealed that RGFP966 significantly inhibited the upregulation of RIPK1. Cellular thermal displacement assay and molecular docking demonstrated the physical binding of RGFP966 to HDCA3. In addition, RIPK1 knockdown cell assay signified that RGFP966 directly targeted RIPK1 and inhibited RIPK1 kinase activity. In summary, these findings established the efficacy of the HDAC3 inhibitor RGFP966 in treating AKI.
Super-fast breeding of all-female giant grass carp by tiny zebrafish
Authors: Sun Yonghua , Ye Ding , Wang Chaofan , Zhu Junwen , Hao Yongkang , Li Linglu , Li Yongming , Tu Yi-Xuan , Wang Xiaosi , Ren Zhiqin , Wang Houpang , He Mudan 
Published: May 2024

Abstract

Grass carp (Ctenopharyngodon idellus), a prominent species in freshwater aquaculture, boasts one of the largest body sizes and global production yields. However, the reproduction and genetic breeding of grass carp has been significantly hindered, primarily due to its protracted sexual maturation period of four to five years and the need for extensive cultivation space. In this study, we develop a super-fast strategy to breed all-female grass carp within half a year, leveraging surrogate production in a small-sized laboratory fish, zebrafish (Danio rerio). We identify and isolate female germline stem cells (GSCs) from juvenile grass carp at three months post-fertilization (mpf). The female GSCs with XX chromosomes are transplanted into germ cell-depleted zebrafish larvae at five days post-fertilization (dpf). The transplanted grass carp XX germ cells undergo rapid spermatogenesis in the zebrafish recipient. At three months after transplantation, all the zebrafish recipients develop into males capable of producing all-X sperm derived from donor grass carp. When these sperm are fertilized with wildtype grass carp eggs, a population of all-female grass carp is generated. This groundbreaking achievement highlights the feasibility of surrogate production of large-sized fish species in small laboratory fishes, and opens a new avenue for advancing genetic breeding in aquaculture.
Association Between Oxidative Balance Score and Osteoporosis in U.S. Adults: The National Health and Nutrition Examination Survey (NHANES) 2005-2020
Authors: Wen Xu , Zhang Jianxin , Ma Guangbin , Zhu Bingrui , Han Yingguang 
Published: May 2024

Abstract

Background
Osteoporosis (OP) is a prevalent disease that increases the risk of fractures and affects quality of life. Although there are many factors that contribute to OP, there are fewer studies on the relationship between oxidative balance score (OBS) and OP.
Methods
We conducted a cross-sectional analysis to examine the association of OBS with the prevalence of OP among U.S. adults using National Health and Nutrition Examination Survey (NHANES) data from 2005 to 2020. A final sample of 18,837 participants was included after exclusions. OBS was calculated from dietary and lifestyle data, and OP status was determined using bone mineral density (BMD) measurements. Logistic regression models and restricted cubic spline (RCS) analyses were used to explore the association between OBS and OP after adjusting for confounders.
Results
Our study demonstrated an inverse association between OBS and the prevalence of OP. For every unit increase in OBS, there was a 3% reduction in the odds of OP after adjustment (OR = 0.97, 95%CI: 0.96–0.99). Higher dietary OBS was associated with reduced OP risk, while an improved lifestyle OBS corresponded to higher OP incidence (P < 0.05). A linear inverse relationship between continuous OBS values and OP risk was observed, and subgroup analyses revealed that females experienced more pronounced protection as OBS increased.
Conclusion
The present study suggests an inverse relationship between OBS and OP in adults, with dietary OBS inversely linked to OP prevalence and lifestyle OBS positively associated. In addition, the association between OBS and OP differed between sexes.
Socioeconomic pathways toward sustainable food systems
Authors: Chrisendo Daniel , Heikonen Sara , Piipponen Johannes , Banafa Thomas , Deryng Delphine , El-Wali Mohammad , Heino Matias , Irz Xavier , Jalava Mika , Láng-Ritter Josias , Mazac Rachel , Niva Venla , Pihlajamäki Mia , Roitto Marja , Tuomisto Hanna , Kummu Matti 
Published: May 2024

Abstract

Recommended solutions and innovations to shape sustainable food systems need to be socioeconomically feasible to be implemented. The numerous publications and the nuance of the topic obfuscate the comprehension of the most crucial socioeconomic measures required for successful implementation and concrete policy formulation. Therefore, a clear and comprehensive overview of available evidence on sustainable food systems is needed, especially focusing on the socioeconomic feasibility, which has not been done before. To address this research gap, we systematically screened over 1700 articles and selected 349 for detailed review, investigating socioeconomic attributes corresponding to successful implementations of sustainable food system transformations. We found that sustainable food systems have various meanings across the scholarship and lack harmonized principles. Moreover, the socioeconomic effects on sustainability are often merely assumed instead of rigorously measured. According to the reviewed articles, different actors require different socioeconomic interventions to attain sustainable food systems: i) producers with strong social capital that induces trust among farmers, as well as economic incentives, have enhanced capabilities to promote sustainability, ii) consumers benefit from improved information provisioning and lower prices of sustainable food options, and iii) processors and distributors require better infrastructure to increase the availability of nutritious food and to reduce food loss and waste. Other actors, such as researchers, should disclose their findings widely, while governments should invest in collaborative policy-making and programs that push for sustainable food systems. The results provide a diverse range of efficient socioeconomic recommendations to increase sustainability in our food systems.
Evidence of aberrant anti-Epstein-Barr virus antibody response, though no viral reactivation, in people with post-stroke fatigue
Authors: Mouat Isobel C. , Zhu Li , Aslan Alperen , McColl Barry W. , Allan Stuart M. , Smith Craig J. , Buckwalter Marion S. , McCulloch Laura 
Published: May 2024

Abstract

BACKGROUND Fatigue is a common complication of stroke that has a significant impact on quality of life. The biological mechanisms that underly post-stroke fatigue are currently unclear, however, reactivation of latent viruses and their impact on systemic immune function have been increasingly reported in other conditions where fatigue is a predominant symptom. Epstein-Barr virus (EBV) in particular has been associated with fatigue, including in long-COVID and myalgic encephalomyelitis/chronic fatigue syndrome, but has not yet been explored within the context of stroke. AIMS We performed an exploratory analysis to determine if there is evidence of a relationship between EBV reactivation and post-stroke fatigue.
METHODS In a chronic ischemic stroke cohort (>5 months post-stroke), we assayed circulating EBV by qPCR and measured the titres of anti-EBV antibodies by ELISA in patients with high fatigue (FACIT-F <40) and low fatigue (FACIT-F >41). Statistical analysis between two-groups were performed by t-test when normally distributed according to the Shapiro-Wilk test, by Mann-Whitney test when the data was not normally distributed, and by Fisher’s exact test for categorical data.
RESULTS We observed a similar incidence of viral reactivation between people with low versus high levels of post-stroke fatigue (5 of 22 participants (24%) versus 6 of 22 participants (27%)). Although the amount of circulating EBV was similar, we observed an altered circulating anti-EBV antibody profile in participants with high fatigue, with reduced IgM against the Viral Capsid Antigen (2.244 ± 0.926 vs 3.334 ± 2.68; P = 0.031). Total IgM levels were not different between groups indicating this effect was specific to anti-EBV antibodies (3.23 x 105 ± 4.44 x 104 high fatigue versus 4.60 x 105 ± 9.28 x 104 low fatigue; P= 0.288).
CONCLUSIONS These data indicate that EBV is not more prone to reactivation during chronic stroke recovery in those with post-stroke fatigue. However, the dysregulated antibody response to EBV may be suggestive of viral reactivation at an earlier stage after stroke.
Functional CRISPR-Cas9 knockout screening of the genetic determinants of human fibroblast migration propensity
Authors: Mazzei Antonio , Martewicz Sebastian , Amiri Ramin , Cui Meihua , Elvassore Nicola , Luni Camilla 
Published: May 2024

Abstract

Directional cell migration plays a central role in a wide range of physiological and pathological conditions, such as inflammation and cancer. Steps involved in cell migration include cell polarization, formation of membrane protrusions at the cell front side and adhesion disassembly at the rear side, and a general cytoskeletal rearrangement. However, there are cell-specific and context-specific molecular events acting in the process. Here, we show how to screen for genes and miRNAs involved in migration by the direct integration of a high-throughput gene editing method, the CRISPR-Cas9 knockout pool screening, and a well-established functional assay, the transwell migration assay. We applied this methodology to human fibroblasts migrating in the presence of a biochemical gradient. The results confirm known genes involved in migration, but also highlight new candidates, like the ectopically expressed family of olfactory receptors. This work establishes a methodological advancement in the use of CRISPR technology for functional screening, and represents a resource for candidate genes and miRNA playing a role in human fibroblast directional migration.