bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microfluidic Metasurfaces: A New Frontier in Electromagnetic Wave Engineering
Authors: Qin Jin , Jiang Shibin , Li Shibin , He Shaowei , Zhu Weiming 
Published: June 2024

AbstractMetasurfaces, as 2D artificial electromagnetic materials, play a pivotal role in manipulating electromagnetic waves by controlling their amplitude, phase, and polarization. Achieving this control involves designing subwavelength meta‐molecules with specific geometries and periodicities. In the context of microfluidic metasurfaces, optical properties can be dynamically modulated by altering either the geometric structure of liquid meta‐molecules or the refractive index of the liquid medium. Leveraging the fluidity of liquid materials, microfluidic metasurfaces exhibit remarkable performance in terms of reconfigurability and flexibility. These properties not only establish a cutting‐edge research area but also broaden the scope of applications for active metasurface devices. Additionally, the integration of metasurfaces within microfluidic systems has led to novel functionalities, including enhanced particle manipulation and sensor technologies. Compared to conventional solid‐material‐based metasurfaces, microfluidic metasurfaces offer greater design freedom, making them advantageous for diverse fields such as electromagnetic absorption, optical sensing, holographic displays, and tunable optical meta‐devices like flat lenses and polarizers. This review provides insights into the characteristics, modulation techniques, and potential applications of microfluidic metasurfaces, illuminating both the current research landscape and promising avenues for further explorations.
A Multiomic Analysis to Identify Drivers of Subclinical Vascular Disease in Systemic Lupus Erythematosus
Authors: Oliveira Christopher , Temesgen‐Oyelakin Yenealem , Naqi Mohammad , Davis Michael , Naz Faiza , Dell'Orso Stefania , Brooks Stephen , Kuhn Skyler , Hill Tom , Li Xiaobai , Patel Nidhi , Parel Philip , Gadina Massimo , Gupta Sarthak , Mehta Nehal , Hasni Sarfaraz A. , Kaplan Mariana J. 
Published: June 2024

ObjectiveSystemic lupus erythematosus (SLE) increases cardiovascular disease (CVD) risk, and this is not explained by traditional risk factors. Characterization of blood immunologic signatures that associate with subclinical CVD and predict its progression has been challenging and may help identify subgroups at risk.MethodsPatients with SLE (n = 77) and healthy controls (HCs) (n = 27) underwent assessments of arterial stiffness, vascular wall inflammation, and coronary atherosclerosis burden with cardio‐ankle vascular index (CAVI); fluorodeoxyglucose–positron emission tomography/computed tomography (CT) (target‐to‐background ratio [TBR]); and coronary CT angiography. Whole blood bulk RNA sequencing was performed in a subset of study participants (HC n = 10, SLE n = 20). In a partially overlapping subset (HC n = 24, SLE n = 64), serum inflammatory protein biomarkers were quantified with an Olink platform.ResultsCAVI, TBR, and noncalcified coronary plaque burden (NCB) were increased in patients with SLE compared to HCs. When comparing patients with SLE with high CAVI scores to those with low CAVI scores or to HCs, there was a down‐regulation of genes in pathways involved in the cell cycle and differentially regulated pathways related to metabolism. Distinct serum proteins associated with increased CAVI (CCL23, colony‐stimulating factor 1, latency‐activating peptide transforming growth factor β1, interleukin 33 [IL‐33], CD8A, and IL‐12B), NCB (monocyte chemotactic protein 4 and FMS‐like tyrosine kinase 3 ligand [Flt3L]), and TBR (CD5, IL‐1α, AXIN1, cystatin D [CST5], and tumor necrosis factor receptor superfamily 9; P < 0.05).ConclusionBlood gene expression patterns and serum proteins that associate with worse vascular phenotypes suggest dysregulated immune and metabolic pathways linked to premature CVD. Cytokines and chemokines identified in associations with arterial stiffness, inflammation, and NCB in SLE may allow for characterization of new CVD biomarkers in lupus.
Recent Progress on Transition Metal Catalyzed Macrocyclizations Based on C−H Bond Activation at Heterocyclic Scaffolds
Authors: Das Sarbojit , Pradhan Tapan Kumar , Samanta Rajarshi 
Published: June 2024

AbstractMacrocycles are essential in protein‐protein interactions and the preferential intake of bioactive scaffolds. Macrocycles are commonly synthesized by late‐stage macrolactonizations, macrolactamizations, transition metal‐catalyzed ring‐closing metathesis, S−S bond‐forming reactions, and copper‐catalyzed alkyne–azide cycloaddition. Recently, transition metal‐catalyzed C−H activation strategies have gained significant interest among chemists to synthesize macrocycles. This article provides a comprehensive overview of the transition metal‐catalyzed macrocyclization via C−H bond functionalization of heterocycle‐containing peptides, annulations, and heterocycle‐ring construction through direct C−H bond functionalization. In the first part, palladium salt catalyzed coupling with indolyl C(sp3)−H and C(sp2)−H bonds for macrocyclization is reported. The second part summarizes rhodium‐catalyzed macrocyclizations via site‐selective C−H bond functionalization. Earth‐abundant, less toxic 3d metal salt Mn‐catalyzed cyclizations are reported in the latter part. This summary is expected to spark interest in emerging methods of macrocycle production among organic synthesis and chemical biology practitioners, helping to develop the discipline. We hope that this mini‐review will also inspire synthetic chemists to explore new and broadly applicable C−C bond‐forming strategies for macrocyclization via intramolecular C−H activation.
Prussian Blue‐Assisted NIR Triggered In‐Situ Polymerized Nanocomposite Hydrogel for Wound Repair
Authors: Wu Qimeng , Zhang Zhixue , Li Yao , Gu Yuan , Ding Xiaokang , Hu Hao , Xu Fujian 
Published: June 2024

AbstractHydrogels are commonly used as wound dressings to help maintain a moist environment around the wound and isolate contaminants, thus promoting healing. For irregular wounds, the slow healing process and even infection may occur due to the inability of dressings to adhere well to the wound. Prussian blue (PB) is a metal‐organic framework (MOF) material with excellent photothermal conversion and superior stability. In this paper, a kind of near‐infrared (NIR) light triggered in‐situ polymerized antimicrobial hydrogel was prepared. The free radical initiator was encapsulated in the hollow PB by a phase change material (PCM) to maintain stability. The raised temperature triggered by NIR induced the release and decomposition of the initiator. The matrix was formed by the cross‐linking of double bonds on modified chitosan. The quaternary amine groups of modified chitosan and the photothermal properties of PB enhanced the antimicrobial properties of the hydrogel. High‐quality wound healing was demonstrated in the whole skin defect model. This study provides a new reference for the preparation of in‐situ polymerized hydrogel dressings for irregular wounds.
Trastuzumab‐induced toxic epidermal necrolysis in a Her‐2‐positive metastatic breast cancer patient—A rare case report
Authors: Ferdause Jannatul , Momtahena Sura Jukrup , Karim Rubama , Chowdhury Aditi Paul , Hossain Nowshin Taslima , Islam Md Ariful , Habib Maruf Bin , Kadir A. K. M. Shafiul , Haque Md Ariful 
Published: June 2024

Key Clinical MessageToxic Epidermal Necrolysis (TEN) is a rare, but potentially fatal mucocutaneous reaction, that may occur due to an immunologic response to certain medications. However, TEN triggered by Trastuzumab is extremely rare. Early diagnosis, recognition, and prompt cessation of the offending drugs and initiation of steroid therapy with supportive management are the most important actions for managing TEN. Although rare, it is important to be vigilant about this potential adverse reactions associated with trastuzumab to ensure patient safety and contribute to better outcomes.
Electrochemical Synthesis of Itaconic Acid Derivatives via Chemodivergent Single and Double Carboxylation of Allenes with CO2
Authors: Brunetti Andrea , Garbini Mauro , Autuori Giuseppe , Zanardi Chiara , Bertuzzi Giulio , Bandini Marco 
Published: June 2024

AbstractLeveraging electrochemistry, a new synthesis of non‐natural derivatives of itaconic acid is proposed by utilizing carbon dioxide (CO2) as a valuable C1 synthon. An electrochemical cross‐electrophile coupling between allenoates and CO2 was targeted, allowing for the synthesis of both mono‐ and di‐carboxylation products in a catalyst‐ and additive‐free environment (yields up to 87 %, 30 examples). Elaboration of the model mono‐carboxylation product, and detailed cyclovoltammetric, as well as mechanistic analyses complete the present investigation.
Borospherene in the Nanohoop: Complexation and Aromaticity of Neutral and Dioxidized Cycloparaphenylene Supramolecules with B40 and C60 Fullerenes
Authors: Lingas Rafael , Charistos Nickolas D. , Muñoz‐Castro Alvaro 
Published: June 2024

AbstractSupramolecular complexes of carbon nanohoops with fullerenes play a key role for the design of novel nanomaterials with technological applications. Herein we investigate with density functional theory (DFT) methods the capability of neutral and dioxidized cycloparaphenylenes (CPPs) to encapsulate all‐boron fullerene B40. Our results show that [9]CPP and [10]CPP are feasible host candidates to encapsulate B40 displaying comparable complexation energies with the all‐carbon analog [10]CPP⊃C60. Upon dioxidation the host‐guest interactions are not affected, whereas the positive charge is delocalized on the CPPs leading to global aromatic character of the hosts. Consequently, the dicationic complexes [n]CPP2+⊃B40 and [10]CPP2+⊃C60 display augmented global shielding cones that strongly shield the guests, as manifested by large upfield shifts in 11B‐NMR and 13C‐NMR signals. Hence, CPP complexes with carbon fullerenes can be extended borospherene B40 host‐guest complexes, as well as to doubly oxidized species stabilized by global host aromaticity, expanding our understanding of carbon nanohoop complexes to boron‐based fullerenes.
Chelation Protection for Zinc Anode of Aqueous Batteries
Authors: Liu Ao , Dong Xiaoyu , Liu Youfa , Peng Cong , Huang Yan 
Published: June 2024

AbstractThis mini‐review comprehensively outlines the latest advancements in protecting zinc anodes in zinc‐ion batteries (ZIBs) through chelation mechanisms. Chelation involves the coordination of ligands with Zn2+, offering promising strategies to address challenges such as dendrite formation and hydrogen evolution reactions. However, there is a lack of comprehensive and unified evaluation of chelation‘s protective effect on the zinc anode, which hinders a thorough assessment of chelation‘s effectiveness. Recent studies have demonstrated the excellent protective performance of chelation in altering solvation structures, modifying SEI structures, and selectively adsorbing species on the zinc anode. Furthermore, while chelation demonstrates significant benefits for the zinc anode, its impact on cathode materials must also be considered. Proper selection of chelation strengths and compatible cathode materials is essential for overall battery performance. Future research directions include exploring the effects of different ligands and coordination numbers on battery performance and extending chelation strategies to other secondary metal batteries. Understanding and optimizing chelation mechanisms are critical for advancing the development of high‐performance ZIBs and other metal‐ion battery technologies.
Rational Design of Transition‐Metal‐Based Catalysts for the Electrochemical 5‐Hydroxymethylfurfural Reduction Reaction
Authors: Li Siqi , Kan Ziwang , Bai Jiaxiao , Ma Ang , Lu Jing , Liu Song 
Published: June 2024

AbstractThe electrochemical reduction reaction (HMFRR) of 5‐hydroxymethylfurfural (HMF) has emerged as a promising avenue for the utilization and refinement of the biomass‐derived platform molecule HMF into high‐value chemicals, addressing energy sustainability challenges. Transition metal electrocatalysts (TMCs) have recently garnered attention as promising candidates for catalyzing HMFRR, capitalizing on the presence of vacant d orbitals and unpaired d electrons. TMCs play a pivotal role in facilitating the generation of intermediates through interactions with HMF, thereby lowering the activation energy of intricate reactions and significantly augmenting the catalytic reaction rate. In the absence of comprehensive and guiding reviews in this domain, this paper aims to comprehensively summarize the key advancements in the design of transition metal catalysts for HMFRR. It elucidates the mechanisms and pH dependency of various products generated during the electrochemical reduction of HMF, with a specific emphasis on the bond‐cleavage angle. Additionally, it offers a detailed introduction to typical in‐situ characterization techniques. Finally, the review explores engineering strategies and principles to enhance HMFRR activity using TMCs, particularly focusing on multiphase interface control, crystal face control, and defect engineering control. This review introduces novel concepts to guide the design of HMFRR electrocatalysts, especially TMCs, thus promoting advancements in biomass conversion.
A straightforward protocol to sample morphological traits of dragonflies and damselflies in the field
Authors: Novella Fernandez Roberto 
Published: June 2024

AbstractScarcity of morphological data limits the potential of functional ecology approaches, which rely on traits to elucidate ecological processes. Dragonflies and damselflies (Odonata) are a frequently used ecological model for which, however, only limited morphological data is available. Here, it is presented a field sampling protocol to collect ecologically relevant yet largely unavailable morphological traits of Odonata. The protocol enables the straightforward collection of traits from living individuals directly in the field. Those traits include body mass, wing area and wing loading as well as thorax width, hindwing length and body length. Furthermore, the protocol allows for posterior wing morphometric analyses. The protocol proved to be robust and universally applicable based on testing on roughly half (76) of all European odonate species. The use of this protocol can increase our understanding of odonatan morphology at interspecific and intraspecific levels and assist in developing mechanistic understanding of their ecology.
Incremental value of C‐reactive protein to the MEESSI acute heart failure risk score
Authors: Wussler Desiree , Belkin Maria , Shrestha Samyut , Wernicke Hannah , Papachristou Androniki , Nowak Albina , Aliyeva Fatima , Mork Constantin , Strebel Ivo , Huré Gabrielle Valerie Francoi , Weil Dominic , Michou Eleni , Kozhuharov Nikola , Gualandro Danielle M. , Puelacher Christian , Miró Oscar , Rossello Xavier , Martín‐Sánchez Francisco Javier , Pocock Stuart J. , Goudev Assen , Breidthardt Tobias , Mueller Christian 
Published: June 2024

AbstractAimsWe hypothesized that the current gold standard for risk stratification of patients with acute heart failure (AHF), the Multiple Estimation of risk based on the Emergency department Spanish Score In patients with AHF (MEESSI‐AHF) risk score, can be further improved by adding systemic inflammation as quantified by C‐reactive protein (CRP).Methods and resultsIn a prospective multicentre diagnostic study (BASEL V), AHF was centrally adjudicated by two independent cardiologists. The MEESSI‐AHF risk score was calculated using an established reduced and recalibrated model containing 12 independent risk factors. Model extension was performed by refitting and adding CRP in the logistic regression model with 30‐day mortality as binary outcome. Discrimination, calibration and clinical usefulness were used to assess the performance of the extended Multiple Estimation of risk based on the Emergency department Spanish Score In patients (MEESSI) model. Validation was performed in an independent, retrospective and single‐centre AHF cohort. Among 1208 AHF patients with complete data allowing calculation of the recalibrated MEESSI and the extended MEESSI models, the prognostic accuracy for 30‐day mortality of the extended MEESSI model (c‐statistic 0.83, 95% confidence interval [CI] 0.79–0.87) was significantly higher compared to the recalibrated model (c‐statistic 0.79, 95% CI 0.75–0.83, p = 0.013). The extended model allowed to stratify a higher percentage of patients into the lowest risk group compared to the recalibrated model (33.1% vs. 20.3%). Demonstrating a calibration plot's slope of 1.00 (95% CI 0.81–1.19) and an intercept of 0.0 (95% CI −0.22 to 0.22), the extended MEESSI model achieved excellent and improved calibration. Results were confirmed in the independent validation cohort (n = 575).ConclusionsQuantifying inflammation using CRP concentration provided incremental value in AHF risk stratification using the established MEESSI model.
The effect of dextrose prolotherapy on patients diagnosed with knee osteoarthritis: A comprehensive systematic review and meta‐analysis of interventional studies
Authors: Khateri Sorour , Nejad Fatemeh Behbahani , Kazemi Farnoush , Alaei Behnaz , Azami Mobin , Moradkhani Asra , Majidi Lobat , Moradi Yousef 
Published: June 2024

AbstractBackground and AimsThe primary objective of this systematic review and meta‐analysis was to assess the impact of dextrose prolotherapy on individuals diagnosed with knee osteoarthritis (KOA).MethodsTo conduct a thorough investigation, a variety of leading international databases were checked, including PubMed (Medline), Scopus, Web of Sciences, EMBASE (Elsevier), ClinicalTrials.gov, and the Cochrane Library. The search covered a period from January 2000 to the end of June 2023, which facilitated the collection of relevant studies.ResultsThe findings of the study revealed that when the studies utilizing the Western Ontario McMaster Universities Index tool (WOMAC) were combined, patients with KOA who received prolotherapy experienced an improvement in function compared with those who received other treatments (SMD: 0.20; 95% Confidence Interval [1]: −0.11, 0.51; p value SMD = 0.221; I2: 78.49%; pheterogeneity < 0.001). Additionally, there was a decrease in mean pain and stiffness among patients who received prolotherapy compared with those who received other treatments or a placebo [(SMD: −0.95; 95% CI: ‐1.14, −0.76; p value SMD < 0.001; I2: 59.35%; pheterogeneity = 0.070) and (SMD: −0.21; 95% CI: −0.32, −0.10; p value SMD < 0.001; I2: 88.11%; pheterogeneity < 0.001)]. Furthermore, based on the Visual Analog Scale (VAS) score, there was a reduction of 0.81 units out of 10 in mean pain for patients with KOA who received prolotherapy (SMD: −0.81; 95% CI: −5.63, 4.10; p value SMD = 0.693; I2: 48.54%; pheterogeneity = 0.08).ConclusionDrawing from the data analysis performed in this meta‐analysis, it is apparent that dextrose prolotherapy exhibits promising effectiveness in reducing joint pain and stiffness, as well as improving functional performance in individuals suffering from KOA. Furthermore, it is recommended that forthcoming studies incorporate follow‐up periods to guide decisions concerning the duration of prolotherapy's effects.
Response of Bangladesh to the World Health Organization call to eliminate cervical cancer as a public health issue: An observational report
Authors: Reza Sejuti , Dewan Syed Masudur Rahman , Islam Mohammad Safiqul , Shahriar Mohammad 
Published: June 2024

AbstractBackgroundDespite being preventable, cervical cancer remains a leading cause of mortality among Bangladeshi women. This article addresses the trends in Bangladesh's response to the World Health Organization's (WHO) request for the eradication of cervical cancer within the nation.DiscussionWhen it comes to cervical cancer, healthcare institutions need to be concerned in terms of protocols for diagnosis and treatment, staff education, and available resources. More than a quarter of all female cancers in Bangladesh are caused by cervical cancer, which can be prevented through better healthcare infrastructure, earlier diagnosis, more qualified healthcare professionals, improved urban and rural hospital infrastructure, community‐based clinics, expanded affordable vaccinations, school‐based delivery systems, adoption of single‐dose vaccine schedules, raising awareness, and compiling a registry of previously affected results. WHO applauds Bangladesh's Ministry of Health and Family Welfare for its efforts to develop the National Strategy for cervical cancer prevention and control, which will guide and strengthen the country's activities to prevent and treat cervical cancer.ConclusionThe endeavor to eradicate this global disease burden should not be limited to Bangladesh; all nations should participate collectively to prevent the malignancy from returning and threatening human civilization.
Sculpting the future: A narrative review of 3D printing in plastic surgery and prosthetic devices
Authors: Zahid Muhammad Jawad , Mavani Parit , Awuah Wireko Andrew , Alabdulrahman Mohammad , Punukollu Rachana , Kundu Arnab , Mago Arpit , Maher Karam , Adebusoye Favour T. , Khan Tehreem Naseer 
Published: June 2024

AbstractBackground and AimsThe advent of 3D printing has revolutionized plastic surgery and prosthetic devices, providing personalized solutions for patients with traumatic injuries, deformities, and appearance‐related conditions. This review offers a comprehensive overview of 3D printing's applications, advantages, limitations, and future prospects in these fields.MethodsA literature search was conducted in PubMed, Google Scholar, and Scopus for studies on 3D printing in plastic surgery.Results3D printing has significantly contributed to personalized medical interventions, with benefits like enhanced design flexibility, reduced production time, and improved patient outcomes. Using computer‐aided design (CAD) software, precise models tailored to a patient's anatomy can be created, ensuring better fit, functionality, and comfort. 3D printing allows for intricate geometries, leading to improved aesthetic outcomes and patient‐specific prosthetic limbs and orthoses. The historical development of 3D printing, key milestones, and breakthroughs are highlighted. Recent progress in bioprinting and tissue engineering shows promising applications in regenerative medicine and transplantation. The integration of AI and automation with 3D printing enhances surgical planning and outcomes. Emerging trends in patient‐specific treatment planning and precision medicine are potential game‐changers. However, challenges like technical considerations, economic implications, and ethical issues exist. Addressing these challenges and advancing research in materials, design processes, and long‐term outcomes are crucial for widespread adoption.ConclusionThe review underscores the increasing adoption of 3D printing in healthcare and its impact on plastic surgery and prosthetic devices. It emphasizes the importance of evaluating the current state and addressing knowledge gaps through future research to foster further advancements