bluuebunny/crossref_metadata_2025_split huggingface dataset:
Project to improve the management of the head injury patients presenting to the emergency department
Authors: Hassan Waseem , Naveed Asif , Khan Zuhair 
Published: April 2024

IntroductionAt Sandwell General Hospital, there was no risk stratification tool or pathway for head injury (HI) patients presenting to the emergency department (ED). This resulted in significant delays in the assessment of HI patients, compromising patient safety and quality of care.AimsTo employ quality improvement methodology to design an effective adult HI pathway that: ensured >90% of high-risk HI patients being assessed by ED clinicians within 15 min of arrival, reduce CT turnaround times, and aiming to keep the final decision making <4 hours.MethodsSWOT analysis was performed; driver diagrams were used to set out the aims and objectives. Plan-Do-Study-Act cycle was used to facilitate the change and monitor the outcomes. Process map was designed to identify the areas for improvement. A new HI pathway was introduced, imaging and transporting the patients was modified, and early decisions were made to meet the standards.ResultsData were collected and monitored following the interventions. The new pathway improved the proportion of patients assessed by the ED doctors within 15 min from 31% to 63%. The average time to CT head scan was decreased from 69 min to 53 min. Average CT scan reporting time also improved from 98 min to 71 min. Overall, the average time to decision for admission or discharge decreased from 6 hours 48 min to 4 hours 24 min.ConclusionsFollowing implementation of the new HI pathway, an improvement in the patient safety and quality of care was noted. High-risk HI patients were picked up earlier, assessed quicker and had CT head scans performed sooner. Decision time for admission/discharge was improved. The HI pathway continues to be used and will be reviewed and re-audited between 3 and 6 months to ensure the sustained improvement.
Lung volume measurement using chest CT in COVID-19 patients: a cohort study in Japan
Authors: Otake Shiro , Shiraishi Yusuke , Chubachi Shotaro , Tanabe Naoya , Maetani Tomoki , Asakura Takanori , Namkoong Ho , Shimada Takashi , Azekawa Shuhei , Nakagawara Kensuke , Tanaka Hiromu , Fukushima Takahiro , Watase Mayuko , Terai Hideki , Sasaki Mamoru , Ueda Soichiro , Kato Yukari , Harada Norihiro , Suzuki Shoji , Yoshida Shuichi , Tateno Hiroki , Yamada Yoshitake , Jinzaki Masahiro , Hirai Toyohiro , Okada Yukinori , Koike Ryuji , Ishii Makoto , Hasegawa Naoki , Kimura Akinori , Imoto Seiya , Miyano Satoru , Ogawa Seishi , Kanai Takanori , Fukunaga Koichi 
Published: April 2024

ObjectiveThis study aimed to investigate the utility of CT quantification of lung volume for predicting critical outcomes in COVID-19 patients.MethodsThis retrospective cohort study included 1200 hospitalised patients with COVID-19 from 4 hospitals. Lung fields were extracted using artificial intelligence-based segmentation, and the percentage of the predicted (%pred) total lung volume (TLC (%pred)) was calculated. The incidence of critical outcomes and posthospitalisation complications was compared between patients with low and high CT lung volumes classified based on the median percentage of predicted TLCct(n=600 for each). Prognostic factors for residual lung volume loss were investigated in 208 patients with COVID-19 via a follow-up CT after 3 months.ResultsThe incidence of critical outcomes was higher in the low TLCct(%pred) group than in the high TLCct(%pred) group (14.2% vs 3.3%, p<0.0001). Multivariable analysis of previously reported factors (age, sex, body mass index and comorbidities) demonstrated that CT-derived lung volume was significantly associated with critical outcomes. The low TLCct(%pred) group exhibited a higher incidence of bacterial infection, heart failure, thromboembolism, liver dysfunction and renal dysfunction than the high TLCct(%pred) group. TLCct(%pred) at 3 months was similarly divided into two groups at the median (71.8%). Among patients with follow-up CT scans, lung volumes showed a recovery trend from the time of admission to 3 months but remained lower in critical cases at 3 months.ConclusionLower CT lung volume was associated with critical outcomes, posthospitalisation complications and slower improvement of clinical conditions in COVID-19 patients.
Safety and effectiveness assessment of the surpass evolve (SEASE): a post-market international multicenter study
Authors: Vivanco-Suarez Juan , Dibas Mahmoud , Lopes Demetrius Klee , Hanel Ricardo A , Martínez-Galdámez Mario , Rodriguez-Calienes Aaron , Cortez Gustavo M , Fifi Johanna T , Devarajan Alex , Toth Gabor , Patterson Thomas , Altschul David , Pereira Vitor M , Liu Eileen , Puri Ajit S , Kuhn Anna Luisa , Guerrero Waldo R , Khandelwal Priyank , Bach Ivo , Kan Peter , Edhayan Gautam , Given Curtis , Narayanan Sandra , Gross Bradley A , Farooqui Mudassir , Galecio-Castillo Milagros , Derakhshani Shahram , Ortega-Gutierrez Santiago 
Published: April 2024

BackgroundFlow diverters are the first-line treatment for specific intracranial aneurysms (iA). Surpass Evolve (SE) is a new-generation 64-wire flow diverter with a high braid angle. Current literature on the SE is limited. We aimed to report the first international real-world experience evaluating the safety and effectiveness of the SE.MethodsThe Safety and Effectiveness Assessment of the Surpass Evolve (SEASE) was a multicenter retrospective international post-marketing cohort study including consecutive patients treated with SE for iAs between 2020 and 2022. Demographic, clinical, and angiographic data were collected. Primary effectiveness was independent core lab adjudicated complete occlusion rates (Raymond-Roy Class 1) at last follow-up. Primary safety were major ischemic/hemorrhagic events and mortality.ResultsIn total, 305 patients with 332 aneurysms underwent SE implantation. The patients had a median age of 59 [50-67] years, and 256 (83.9%) were female. The baseline modified Rankin scale score was 0–2 in 291 patients (96.7%). Most aneurysms were unruptured (285, 93.4%) and saccular (309, 93.1%). Previous treatment was present in 76 (22.9%) patients. The median aneurysm size was 5.1 [3.4–9.0] mm, and the median neck width was 3.6 [2.7–5.1] mm. Most aneurysms were in the internal carotid artery C6 ophthalmic segment (126, 38.0%), followed by the communicating segment (58, 17.5%). At median 10.2 [6.4–12.9] months follow-up, 233 (73.0%) aneurysms achieved complete occlusion. After adjusting for confounders, complete occlusion remained consistent. Major stroke and procedure-related mortality were reported in 6 (2%) and 2 (0.7%) cases, respectively.ConclusionThese results demonstrate that SE has a consistently high effectiveness and favorable safety for the treatment of iAs.
Genetics impact risk of Alzheimer’s disease through mechanisms modulating structural brain morphology in late life
Authors: Korologou-Linden Roxanna , Xu Bing , Coulthard Elizabeth , Walton Esther , Wearn Alfie , Hemani Gibran , White Tonya , Cecil Charlotte , Sharp Tamsin , Tiemeier Henning , Banaschewski Tobias , Bokde Arun , Desrivières Sylvane , Flor Herta , Grigis Antoine , Garavan Hugh , Gowland Penny , Heinz Andreas , Brühl Rüdiger , Martinot Jean-Luc , Paillère Martinot Marie-Laure , Artiges Eric , Nees Frauke , Orfanos Dimitri Papadopoulos , Paus Tomáš , Poustka Luise , Millenet Sabina , Fröhner Juliane H , Smolka Michael , Walter Henrik , Winterer Jeanne , Whelan Robert , Schumann Gunter , Howe Laura D , Ben-Shlomo Yoav , Davies Neil M , Anderson Emma Louise 
Published: April 2024

BackgroundAlzheimer’s disease (AD)-related neuropathological changes can occur decades before clinical symptoms. We aimed to investigate whether neurodevelopment and/or neurodegeneration affects the risk of AD, through reducing structural brain reserve and/or increasing brain atrophy, respectively.MethodsWe used bidirectional two-sample Mendelian randomisation to estimate the effects between genetic liability to AD and global and regional cortical thickness, estimated total intracranial volume, volume of subcortical structures and total white matter in 37 680 participants aged 8–81 years across 5 independent cohorts (Adolescent Brain Cognitive Development, Generation R, IMAGEN, Avon Longitudinal Study of Parents and Children and UK Biobank). We also examined the effects of global and regional cortical thickness and subcortical volumes from the Enhancing NeuroImaging Genetics through Meta‐Analysis (ENIGMA) Consortium on AD risk in up to 37 741 participants.ResultsOur findings show that AD risk alleles have an age-dependent effect on a range of cortical and subcortical brain measures that starts in mid-life, in non-clinical populations. Evidence for such effects across childhood and young adulthood is weak. Some of the identified structures are not typically implicated in AD, such as those in the striatum (eg, thalamus), with consistent effects from childhood to late adulthood. There was little evidence to suggest brain morphology alters AD risk.ConclusionsGenetic liability to AD is likely to affect risk of AD primarily through mechanisms affecting indicators of brain morphology in later life, rather than structural brain reserve. Future studies with repeated measures are required for a better understanding and certainty of the mechanisms at play.
Look-ahead-while-drilling resistivity tools and their role in drilling sedimentary basins containing complex volcanic geology
Authors: Maguire Alistair , Smart Leanne , Layfield Lucinda K. , Bower Mike , Schofield Nick 
Published: April 2024

Developments in ultradeep azimuthal resistivity (UDAR) technology has recently progressed from their application in high-angle and horizontal wells to low-angle and vertical wells. This has presented the opportunity to assess their suitability as derisking tools because of their ability to look ahead of the bit, up to
c.
100 ft (
c.
30.5 m).

Dominated by a complex interplay of structure, sedimentation, and volcanic activity, the NE Atlantic Margin presents a challenging environment to plan and drill wells safely and within planned budget, with many wells drilled within the Faroe–Shetland Basin (FSB) currently the most expensive to-date within the United Kingdom continental shelf (UKCS). The limited number of wells drilled in the FSB and their geographical sparsity relative to those of other areas of the UKCS, make offset analysis and derisking a challenge. The often-unpredictable distribution of igneous rocks throughout the basin presents significant challenges in the planning and drilling of oil and gas wells. Up to 88% of igneous intrusions within the FSB are estimated to be below seismic resolution, which alongside variation in composition, presents significant issues related to drilling safely, efficiently and successfully.
Within this paper, we investigate the use of UDAR technology and how they could be deployed in areas of complex volcanic geology such as the West of Shetland (WoS). This paper reviews the nature of the drilling experiences within the FSB to date, the impact it has on exploration, and how improvements in drilling technology could help decrease nonproductive time (NPT).
A Self-Healing Polymer Binder of Silicon-Based Anode with Enhanced Lithium-Ion Transport Performance
Authors: Bai Haomin , Zhou Zhi , Yang Bo , Liu Wentong , Liu Lili , Wen Jianwu 
Published: April 2024

A multi-functional binder was designed for silicon-based anode lithium-ion battery to alleviate the huge volume expansion of silicon anode during the process of charging and discharging, and to provide ion transport channels to improve the rate performance of electrodes to meet the needs of rapid charging and discharging. In this study, a binder PAA-TUEG which combined the mechanical properties of PAA, the fast self-healing ability provided by the zigzag hydrogen bond in TUEG, and the ion transport ability provided by the ether-oxygen group was synthesized. The effect of different proportion of TUEG binder on the electrochemical performance of the electrode was further investigated. The synthesized PAA-TUEG5% polymer material exhibits a tensilestrength of 0.8 MPa and a fracture elongation of 397%. The Si@PAA-TUEG5% electrode demonstrates reversible capacities of 3035, 2260, and 1249 mAh g−1 at 0.5, 1, and 2 C (1 C = 3500 mAh g−1), respectively. In extended cycling tests, the remaining capacities after 180 cycles at 0.5 and 1 C are 852 and 793 mAh g−1, respectively. This innovative binder, featuring both self-healing ability and enhanced ion transport through dynamic reversible hydrogen bond and ionic bond, presents a promising design concept for the next generation of high-energy-density lithium-ion batteries.
Percepção dos dentistas sobre o trabalho em equipe na estratégia saúde da família: estudo exploratório
Authors: Assanti Amanda Araújo dos Santos , Alonso Carolina Maria do Carmo 
Published: April 2024

The aim of this study was to investigate how dentists perceive their integration in family health teams and to elucidate the limits and possibilities of integration of this professional’s work processes. This is a descriptive and exploratory study of qualitative nature that used the semistructured interview as data collection procedure. The subjects of the research were six dentists who worked for at least six months in Family Health Units of a neighborhood in the city of Rio de Janeiro, Brazil. The analysis of the interviews was based on the principles of content analysis proposed by Bardin. The result of the interviews’ analysis presented two thematic categories that were used to apprehend the aspects related to the insertion of dentists in the work process of the nuclear teams of the Family Health Strategy (FHS), which are: isolation of dentists by the ideation of their attachment to the dental chair and the organization of the dentist’s work in the FHS. This study showed that the dentists surveyed think that their work process is related to a model in which the user is still seen in a fragmentary way although the policy guidelines and the proposed models point in the opposite direction.
Effects of a Global
Rab27a
Null Mutation on Murine PVAT and Cardiovascular Function
Authors: Soucy Ashley , Potts Christian , Kaija Abigail , Harrington Anne , McGilvrey Marissa , Sutphin George L. , Korstanje Ron , Tero Benjamin , Seeker Jacob , Pinz Ilka , Vary Calvin , Ryzhova Larisa , Liaw Lucy 
Published: April 2024

BACKGROUND:
RAB27A is a member of the RAS oncogene superfamily of GTPases and regulates cell secretory function. It, is expressed within blood vessels and perivascular adipose tissue. We hypothesized that loss of RAB27A would alter cardiovascular function.

METHODS:

Body weight of
Rab27a

ash

mice was measured from 2 to 18 months of age, along with glucose resorption at 6 and 12 months of age and glucose sensitivity at 18 months of age. Body weight and cellular and molecular features of perivascular adipose tissue and aortic tissue were examined in a novel C57BL/6J
Rab27a
null strain. Analyses included morphometric quantification and proteomic analyses. Wire myography measured vasoreactivity, and echocardiography measured cardiac function. Comparisons across ages and genotypes were evaluated via 2-way ANOVA with multiple comparison testing. Significance for myography was determined via 4-parameter nonlinear regression testing.

RESULTS:

Genome-wide association data linked rare human
RAB27A
variants with body mass index and glucose handling. Changes in glucose tolerance were observed in
Rab27a

ash

male mice at 18 months of age. In WT (wild-type) and
Rab27a
null male mice, body weight, adipocyte lipid area, and aortic area increased with age. In female mice, only body weight increased with age, independent of RAB27A presence. Protein signatures from male
Rab27a
null mice suggested greater associations with cardiovascular and metabolic phenotypes compared with female tissues. Wire myography results showed
Rab27a
null males exhibited increased vasoconstriction and reduced vasodilation at 8 weeks of age.
Rab27a
null females exhibited increased vasoconstriction and vasodilation at 20 weeks of age. Consistent with these vascular changes, male
Rab27a
null mice experienced age-related cardiomyopathy, with severe differences observed by 21 weeks of age.

CONCLUSIONS:
Global RAB27A loss impacted perivascular adipose tissue and thoracic aorta proteomic signatures, altered vasocontractile responses, and decreased left ventricular ejection fraction in mice.
Moderating Effects of Informal Care on the Relationship Between ADL Limitations and Adverse Outcomes in Stroke Survivors
Authors: Chou Aileen , Beach Scott R. , Lutz Barbara J. , Rodakowski Juleen , Terhorst Lauren , Freburger Janet K. 
Published: April 2024

BACKGROUND:
Stroke survivors with limitations in activities of daily living (ADL) have a greater risk of experiencing falls, hospitalizations, or physical function decline. We examined how informal caregiving received in hours per week by stroke survivors moderated the relationship between ADL limitations and adverse outcomes.

METHODS:
In this retrospective cohort, community-dwelling participants were extracted from the National Health and Aging Trends Study (2011–2020; n=277) and included if they had at least 1 formal or informal caregiver and reported an incident stroke in the prior year. Participants reported the amount of informal caregiving received in the month prior (low [<5.8], moderate [5.8–27.1], and high [27.2–350.4] hours per week) and their number of ADL limitations (ranging from 0 to 7). Participants were surveyed 1 year later to determine the number of adverse outcomes (ie, falls, hospitalizations, and physical function decline) experienced over the year. Poisson regression coefficients were converted to average marginal effects and estimated the moderating effects of informal caregiving hours per week on the relationship between ADL limitations and adverse outcomes.

RESULTS:

Stroke survivors were 69.7% White, 54.5% female, with an average age of 80.5 (SD, 7.6) years and 1.2 adverse outcomes at 2 years after the incident stroke. The relationships between informal caregiving hours and adverse outcomes and between ADL limitations and adverse outcomes were positive. The interaction between informal caregiving hours per week and ADL limitations indicated that those who received the lowest amount of informal caregiving had a rate of 0.12 more adverse outcomes per ADL (average marginal effect, 0.12 [95% CI, 0.005–0.23];
P
=0.041) than those who received the highest amounts.

CONCLUSIONS:
Informal caregiving hours moderated the relationship between ADL limitations and adverse outcomes in this sample of community-based stroke survivors. Higher amounts relative to lower amounts of informal caregiving hours per week may be protective by decreasing the rate of adverse outcomes per ADL limitation.
Gender and Property Relations in Eighteenth-Century Inner Mongolia: Records of Marriage Transactions from Qanggin-Banner (Ordos)
Authors: Heuschert-Laage Dorothea 
Published: April 2024

Abstract
The study is based on a register of changes in household affiliation, which was compiled by local authorities in Inner Mongolia during the Qing dynasty (1636–1911). The records pertain to household divisions, economic compensation in case of divorce and death, and conditions under which divorced or widowed women could (or had to) return to their families of origin. The present article makes the argument that bride-wealth and dowry were both practiced, but the legal dimension of dowry was less prominent than that of bride-wealth. With regard to property relations, gender was intersecting with other factors of social distinction, namely seniority, wealth and status. The complexity of these interactions becomes most apparent when considering the position of widows.
The Relationship between Theological Prolegomena and Imago Dei
Authors: Seals Zachary W. 
Published: April 2024

Abstract
If the content of theology should align with the method of doing theology, then carefully ensuring consistency between prolegomena and the content of dogmatics is essential for the theological task. Yet for many evangelical theologians, scarcity of prolegomenal considerations has led to systemic problems. Here I investigate how the doctrine of the image of God impinges upon our understanding of the nature of theological language, in order to expose a deep yet tacit inconsistency operative within recent evangelical accounts that affirm the univocity of theological predication. In contrast to these works, my claim is that a robust commitment to a comprehensive doctrine of the imago Dei entails an analogical view of human predications about God. In this regard, works in evangelical systematics that simultaneously affirm univocity and a robust doctrine of imago Dei have not sufficiently synthesized the content of their theology with their theological methodology.
Prelapsarian Christological Mediation and the Typology of Adam and Eve in Jerome Zanchi’s De Operibus Dei
Authors: Leslie Andrew M. 
Published: April 2024

Abstract
This article examines the typological patterns that distinguish Jerome Zanchi’s exposition of human creation in his De Operibus Dei intra spatium sex dierum creatis (1591). It argues that Zanchi’s distinctive application of the principle that Christ is the “scope” and “substance” of scripture to the exegesis of the relevant texts in Genesis 1–2 is tied to a conviction that Christ’s mediatorial headship over the church embraces a continuity of operations between the prelapsarian and postlapsarian states. Because of this he believes that the prelapsarian type, or figurative sign, can participate in the antitype, or the spiritual reality the type signifies, without eliding the critical distinction between them, as illustrated in his articulation of the “image of God.”
Touching the Ark or Carrying It?
Authors: Bem Kazimierz 
Published: April 2024

Abstract
The story of the Reformation in the Commonwealth of Poland and Lithuania has been told primarily through the actions of men who purged churches, settled ministers, expelled Catholic priests, and defended the freedom of worship at the local and national level. This article challenges that androcentric perspective, drawing on synodical acts and surviving church visitations to reexamine the religious praxis of Reformed Churches (Calvinist and Church Brethren) in Lesser Poland, Greater Poland, and the Grand Duchy of Lithuania. It finds that, despite the absence of women in historiography, women were involved in shaping the piety and practices of the Reformed Churches from the beginning. From Katarzyna Ostroróg to Ludwika Karolina Radziwiłł women not only participated in the foundation of Protestant churches but also actively challenged patriarchal assumptions.