bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immobilization of Lewis Basic Sites into a Quasi‐Molecular‐Sieving Metal–Organic Framework for Enhanced C3H6/C3H8 Separation
Authors: Liu Puxu , Li Jianhui , Yan Furong , Lian Xin , Xu Jian , Chen Yang , Liu Yutao , Shi Qi , Cui Xili , Sun Lin‐Bing , Li Jinping , Li Libo 
Published: June 2024

AbstractControlling gas sorption through pore engineering is indispensable in molecular recognition and separation processes. The challenge lies in developing high‐efficiency adsorbents for C3H6/C3H8 separation, specifically enhancing the affinity toward C3H6 for high selectivity while maintaining a large gas uptake to obtain high separation efficiency. Herein, this problem can be addressed by controlling host‐guest interactions using Lewis basic sites modulation. A precise steric design of channel pores using an amino group as additional interacting sites enables the synergetic increase in C3H6 adsorption while suppressing the C3H8 adsorption, resulting in a quasi‐molecular‐sieving effect. Among them, TYUT‐23 has a perfect pore size that fits minimum cross‐sectional dimensions of C3H6, affording exceptional binding affinity for the C3H6 molecule. It adsorbs a large amount of C3H6 (2.5 mmol g−1) and concurrently exhibits both remarkably high IAST selectivity (71) under ambient conditions. Equimolar C3H6/C3H8 breakthrough experiments also prove the prominent separation performance of TYUT‐23 for the production of high‐purity C3H6. The C3H6 adsorption/separation mechanism has been investigated using C3H6‐loaded single‐crystal structure analysis. This material demonstrates the potential of optimizing host‐C3H6 interactions using Lewis basic site modulation in industrial separations.
Fabricating Wide‐Temperature‐Range Quasi‐Solid Sodium Batteries with Fast Ion Transport via Tin Additives
Authors: Yang Zhendong , Jiang Haoyang , Li Xiang , Liang Xinghui , Wei Jinping , Xie Zhaojun , Tang Bin , Zhang Yue , Zhou Zhen 
Published: June 2024

AbstractQuasi‐solid sodium batteries, employing quasi‐solid polymer electrolytes (QSPEs) renowned for their high energy density and cost‐effective fabrication, are promising candidates for next‐generation energy storage systems. However, their practical application has encountered impediments such as insufficient ion transport and uneven sodium plating/stripping attributed to suboptimal interfacial compatibility. In this work, an innovative QSPE is developed by incorporating functional additives, specifically fluoroethylene carbonate (FEC) and tin trifluoromethanesulfonate (Sn(OTf)2), into the poly(vinylidenefluoride‐co‐hexafluoropropylene) (PVDF‐HFP)/propylene carbonate (PC) polymer electrolyte. Sn(OTf)2 catalyzes a ring‐opening reaction in PC, thereby reducing transmission barriers and augmenting the transport of sodium ions. Consequently, the resulting HFP‐PC‐FEC‐Sn QSPE demonstrates remarkable ionic conductivity (0.42 mS cm─1) and ion transference number (0.58). Furthermore, it forms a dense and smooth interphase enriched with NaF and metallic Sn, significantly enhancing the long‐term cycling stability of Na symmetric cells, which endure over 3000 h at 0.2 mA cm─2, and effectively suppressing the formation of sodium dendrites. This outstanding electrochemical performance extends to Na3V2(PO4)3/Na full coin and pouch cells across a wide temperature range. This work introduces an innovative approach for designing high‐performance QSPEs suitable for wide‐temperature quasi‐solid sodium batteries.
The Balance Between Shear Flow and Extracellular Matrix in Ovarian Cancer‐on‐Chip
Authors: Chen Changchong , Boché Alphonse , Wang Zixu , Lopez Elliot , Peng Juan , Carreiras Franck , Schanne‐Klein Marie‐Claire , Chen Yong , Lambert Ambroise , Aimé Carole 
Published: June 2024

AbstractOvarian cancer is the most lethal gynecologic cancer in developed countries. In the tumor microenvironment, the extracellular matrix (ECM) and flow shear stress are key players in directing ovarian cancer cells invasion. Artificial ECM models based only on ECM proteins are used to build an ovarian tumor‐on‐chip to decipher the crosstalk between ECM and shear stress on the migratory behavior and cellular heterogeneity of ovarian tumor cells. This work shows that in the shear stress regime of the peritoneal cavity, the ECM plays a major role in driving individual or collective ovarian tumor cells migration. In the presence of basement membrane proteins, migration is more collective than on type I collagen regardless of shear stress. With increasing shear stress, individual cell migration is enhanced; while, no significant impact on collective migration is measured. This highlights the central position that ECM and flow shear stress should hold in in vitro ovarian cancer models to deepen understanding of cellular responses and improve development of ovarian cancer therapeutic platforms. In this frame, adding flow provides significant improvement in biological relevance over the authors’ previous work. Further steps for enhanced clinical relevance require not only multiple cell lines but also patient‐derived cells and sera.
Research Progress on the Application of MOF and MOF‐Based Materials in Nitrogen Reduction
Authors: Zhu Ying , Ji Houqiang , Huang Tianyu , Sun Yangyang , Pang Huan 
Published: June 2024

AbstractElectrocatalytic and photocatalytic nitrogen fixation have become new ways to achieve green nitrogen reduction because of their environmentally friendly and cost‐effective characteristics. At present, there has been an increasing curiosity about using metal‐organic frameworks (MOFs) for photocatalysis and electrocatalysis. However, electrocatalytic and photocatalytic ammonia production is still not practical for practical applications. Having a thorough understanding of nitrogen fixation is necessary for the advancement of practical applications and the development of highly efficient catalysts in the future. The catalytic nitrogen fixation activity of MOF itself is limited. By adjusting the exposure of active sites through low‐temperature calcination and solvent addition, the photogenerated carrier recombination is inhibited, and the adsorption and activation of N2 are enhanced, improving its performance in nitrogen fixation applications. This review examines the reported photocatalysts, electrocatalysts, and photoelectrocatalysts based on MOFs and their associated materials. The underlying mechanism for photocatalysis and electrocatalysis is elucidated. Additionally, an inclusive survey of MOFs and related materials as catalysts for nitrogen reduction reaction (NRR) is presented, with representative examples discussed. Finally, the research progress of MOF‐based catalytic nitrogen fixation materials is summarized and prospected.
Tentacle Microelectrode Arrays Uncover Soft Boundary Neurons in Hippocampal CA1
Authors: Lv Shiya , Mo Fan , Xu Zhaojie , Wang Yu , Yang Gucheng , Han Meiqi , Jing Luyi , Xu Wei , Duan Yiming , Liu Yaoyao , Li Ming , Liu Juntao , Luo Jinping , Wang Mixia , Song Yilin , Wu Yirong , Cai Xinxia 
Published: June 2024

AbstractHippocampal CA1 neurons show intense firing at specific spatial locations, modulated by isolated landmarks. However, the impact of real‐world scene transitions on neuronal activity remains unclear. Moreover, long‐term neural recording during movement challenges device stability. Conventional rigid‐based electrodes cause inflammatory responses, restricting recording durations. Inspired by the jellyfish tentacles, the multi‐conductive layer ultra‐flexible microelectrode arrays (MEAs) are developed. The tentacle MEAs ensure stable recordings during movement, thereby enabling the discovery of soft boundary neurons. The soft boundary neurons demonstrate high‐frequency firing that aligns with the boundaries of scene transitions. Furthermore, the localization ability of soft boundary neurons improves with more scene transition boundaries, and their activity decreases when these boundaries are removed. The innovation of ultra‐flexible, high‐biocompatible tentacle MEAs improves the understanding of neural encoding in spatial cognition. They offer the potential for long‐term in vivo recording of neural information, facilitating breakthroughs in the understanding and application of brain spatial navigation mehanisms.
r‐NG●‐Regulated Electron‐Phonon Coupling to Enhance Hot‐Hole Injection for Inverted Perovskite Solar Cells
Authors: Wang Can , Ma Xiao‐Hui , Ma Xinbo , Zhang Huifeng , Yan Wenlong , Li Yuheng , Xiong Qiu , Zhang Zilong , Liang Lusheng , Yang Ye , Long Run , Tan Yuan‐Zhi , Gao Peng 
Published: June 2024

AbstractExtracting hot‐carriers before they relax back to the band edge will reduce thermal dissipation above the bandgap, which is one of the primary sources of efficiency loss in perovskite solar cells (PSCs). It requires slow cooling of hot‐carriers together with the efficient extraction of hot‐carriers. Here, a novel interface engineering is demonstrated by embedding radical‐containing nanographene (r‐NG●) between perovskite and poly[bis(4‐phenyl)(2,4‐dimethoxyphenyl)‐amine] (PTOAA) to harvest this excess energy. This strategy accelerates the extraction rate of the hot‐hole (3 times that of control at 400 K) by augmenting the relaxation channel, which is related to the “quasi‐SOMO” energy state of r‐NG●. Nonadiabatic molecular dynamics calculation further revealed that radical character promotes the rotation of the cation in perovskite, which contributes to generating strong nonadiabatic couplings and multiple phonon modes. In addition, the band bending effect of buried perovskite and improved conductivity of PTOAA also facilitate exciton dissociation and hole collection efficiency (97.5%). Consequently, the resultant r‐NG● decorated PSCs delivered an impressive efficiency of 24.20%, along with better thermal and humidity stability. Moreover, it can maintain 93% of its initial efficiency after 300 hours of illumination.
Computationally guided design and synthesis of dual‐drug loaded polymeric nanoparticles for combination therapy
Authors: Jin Song , Lan Zhenwei , Yang Guangze , Li Xinyu , Shi Javen Qinfeng , Liu Yun , Zhao Chun‐Xia 
Published: June 2024

AbstractSingle‐drug therapies or monotherapies are often inadequate, particularly in the case of life‐threatening diseases like cancer. Consequently, combination therapies emerge as an attractive strategy. Cancer nanomedicines have many benefits in addressing the challenges faced by small molecule therapeutic drugs, such as low water solubility and bioavailability, high toxicity, etc. However, it remains a significant challenge in encapsulating two drugs in a nanoparticle. To address this issue, computational methodologies are employed to guide the rational design and synthesis of dual‐drug‐loaded polymer nanoparticles while achieving precise control over drug loading. Based on the sequential nanoprecipitation technology, five factors are identified that affect the formulation of drug candidates into dual‐drug loaded nanoparticles, and then screened 176 formulations under different experimental conditions. Based on these experimental data, machine learning methods are applied to pin down the key factors. The implementation of this methodology holds the potential to significantly mitigate the complexities associated with the synthesis of dual‐drug loaded nanoparticles, and the co‐assembly of these compounds into nanoparticulate systems demonstrates a promising avenue for combination therapy. This approach provides a new strategy for enabling the streamlined, high‐throughput screening and synthesis of new nanoscale drug‐loaded entities.
Cognitive integrity in Non‐Demented Individuals with Alzheimer's Neuropathology is associated with preservation and remodeling of dendritic spines
Authors: Guptarak Jutatip , Scaduto Pietro , Tumurbaatar Batbayar , Zhang Wen Ru , Jupiter Daniel , Taglialatela Giulio , Fracassi Anna 
Published: June 2024

AbstractINTRODUCTIONIndividuals referred to as Non‐Demented with Alzheimer's Neuropathology (NDAN) exhibit cognitive resilience despite presenting Alzheimer's disease (AD) histopathological signs. Investigating the mechanisms behind this resilience may unveil crucial insights into AD resistance.METHODSDiI labeling technique was used to analyze dendritic spine morphology in control (CTRL), AD, and NDAN post mortem frontal cortex, particularly focusing on spine types near and far from amyloid beta (Aβ) plaques.RESULTSNDAN subjects displayed a higher spine density in regions distant from Aβ plaques versus AD patients. In distal areas from the plaques, NDAN individuals exhibited more immature spines, while AD patients had a prevalence of mature spines. Additionally, our examination of levels of Peptidyl‐prolyl cis‐trans isomerase NIMA‐interacting 1 (Pin1), a protein associated with synaptic plasticity and AD, showed significantly lower expression in AD versus NDAN and CTRL.DISCUSSIONThese results suggest that NDAN individuals undergo synaptic remodeling, potentially facilitated by Pin1, serving as a compensatory mechanism to preserve cognitive function despite AD pathology.Highlights
Spine density is reduced near Aβ plaques compared to the distal area in CTRL, AD, and NDAN dendrites.
NDAN shows higher spine density than AD in areas far from Aβ plaques.
Far from Aβ plaques, NDAN has a higher density of immature spines, AD a higher density of mature spines.
AD individuals show significantly lower levels of Pin1 compared to NDAN and CTRL.
Adsorptive removal of phosphate from aqueous solutions using FeCl3‐immobilized melamine‐formaldehyde‐urea resin
Authors: Ozdemir Olgun Fatos Ayca , Çetin Pınar 
Published: June 2024

AbstractThe surplus phosphorus in aquatic environments trigger eutrophication, an irreversible pollution stage marked by the rapid growth of algae and water plants, a decline in dissolved oxygen levels, and the emergence of dead zones. To address this critical issue, this study focuses on the removal of phosphorus in form of phosphate from aqueous solutions. The research involves the synthesis and characterization of FeCl3‐immobilized melamine‐formaldehyde‐urea resin, an innovative adsorbent, its characterization through Fourier transform infrared spectroscopy, and the evaluation of its adsorption capacity based on Langmuir and Freundlich equilibrium models. The experimental adsorption data fits well with pseudo‐second order kinetic model. Optimal adsorption parameters are carried with batch adsorption technique for 60 min using 0.5 g of adsorbent at pH = 2, achieving 15.55 mg g−1 adsorption capacity, and conducting experiments with tap‐water samples to replicate real‐world scenarios. The research findings have the potential to advance sustainable wastewater treatment technologies and contribute to the mitigation of nutrient pollution in aquatic ecosystems, addressing a pressing environmental concern.
Shelf‐life prediction of silicone‐hollow glass microsphere composite as liner material and its accelerated aging
Authors: Devi Anupama , Mitra Kheyanath , Tiwari Shivam , Srivastava Tanu , Ramakrishna C. , Krishna Mohan S. , Maiti Pralay 
Published: June 2024

AbstractLiner materials have extensive applications in automobile industry, packaging, and aeronautics. One of the specific uses of such materials is in thermal barrier, coating rockets, missile, and other systems used in space and defense. Each liner material exhibits different properties according to their chemical structure and composition. In this study, accelerated thermal aging of the liner material, silicone‐hollow glass microsphere composite (SHGC) has been studied along with the determination of its life span. The effect of such aging on the thermal properties of SHGC has been studied using thermogravimetry. Activation energy of the process has been determined to be in the range of 45–55 KJmol−1. The results have been compared with already reported silicon polymers. Shelf‐life of SHGC composite has also been determined using Arrhenius model. Stochastic model has been applied to determine the lower and upper limits of shelf‐life. Shelf‐life of SHGC is found to be 24 years with 28 and 18 years of upper and lower error limits.
The effects of supplemental instruction derived from peer leaders on student outcomes in undergraduate human anatomy
Authors: Wilson Robert N. , Holman Parker J. , Dragan Martin , MacPherson Rebecca E. K. , Beaudette Shawn M. 
Published: June 2024

AbstractSupplemental instruction (SI) confers student success, as represented by grades, knowledge retention, and student engagement. However, studies often report professional, not undergraduate, program findings. To measure these effects, students studying human anatomy at a university in Ontario, Canada, attended structured (peer‐assisted) or unstructured (nonpeer‐assisted) SI sessions and completed a pre−/post‐survey. Fifty‐eight learners (39 systems (SYS) and 19 musculoskeletal (MSK) anatomy) completed both surveys and had responses analyzed. Both cohorts, maintained initial perceptions across pre−/post‐analyses (MSK p = 0.1376 and SYS p = 0.3521). Resource usage was similar across both cohorts with discrepancies in skeletal model and textbook use. No MSK learner ranked any lab resources as “not at all useful.” MSK learners felt more prepared to write a graded assessment (p = 0.0269), whereas SYS learners did not (p = 0.0680). Stratification of learners in MSK and SYS revealed learners spending between 30 and 60 min in SI sessions during the study period had the highest grades compared to students who spent less than 30 (p = 0.0286) or more than 60 (p = 0.0286) min attending SI sessions, respectively. Most learners in MSK (89.4%) and SYS (66%) concluded that they preferred structured over unstructured SI. Sentiment/thematic analysis using a generative AI‐driven large language model revealed learners held positive perceptions of SI, emphasizing structured learning, resources, personalized learning, and support offered as the most prevalent themes surrounding SI. Ultimately, this study provides evidence that supports SI for improving student outcomes related to perceived preparedness for completing assessments and preferred teaching/learning styles in undergraduate human anatomy.
Clinical evaluation of primary human papillomavirus (HPV) testing with extended HPV genotyping triage for cervical cancer screening: A pooled analysis of individual patient data from nine population‐based cervical cancer screening studies from China
Authors: Dun Changchang , Yuan Meiwen , Zhao Xuelian , Hu Shangying , Arbyn Marc , Zhao Fanghui 
Published: June 2024

AbstractObjectiveTo assess the clinical values of extended human papillomavirus (HPV) genotyping in triage of high‐risk HPV‐positive women, focusing on the trade‐off between cervical precancer detections and colposcopy referrals.MethodsA bivariate random‐effects model was used to estimate the diagnostic accuracy of primary HPV screening with following triage strategies to detect cervical precancers: (i) partial genotyping for HPV16/18 combined with cytological testing at atypical squamous cells of undetermined significance threshold (used as the comparator), (ii) genotyping for HPV16/18/58/52, (iii) genotyping for HPV16/18/58/52/33, (iv) genotyping for HPV16/18/58/33/31, (v) genotyping for HPV16/18/58/52/33/31, and (vi) genotyping for HPV16/18/58/52/33/31/39/51. Internal risk benchmarks for clinical management were used to evaluate the risk stratification of each triage strategy.ResultsA total of 16,982 women (mean age 46.1 years, range 17–69) were included in this analysis. For CIN3+ detection, triage with HPV16/18/58/33/31 genotyping achieved lower positivity (6.85% vs. 7.35%, p = 0.001), while maintaining similar sensitivity (91.35% vs. 96.42%, p = 0.32) and specificity (94.09% vs. 93.67%, p = 0.56) compared with the comparator strategy. Similar patterns were observed for CIN2+ detection. Women with a positive HPV16/18/58/33/31 genotyping test had high enough risk for CIN3+ for colposcopy referral, while the risk for women with a negative test was below the 1‐year return decision threshold according to internal benchmarks.ConclusionsOur findings suggested extended HPV genotyping is of potential to be used as a triage technique integrated into HPV‐based cervical cancer screening, leading to reduced need for colposcopy referral while maintaining similar disease detection and efficient risk stratification.
Harnessing External Irradiation for Precise Activation of Metal‐Based Agents in Cancer Therapy
Authors: Wang Yuting , Meng Liling , Zhao Fang , Zhao Limei , Gao Wei , Yu Qi , Chen Peiyao , Sun Yao 
Published: June 2024

AbstractCancer is a significant global health issue. Platinum‐based chemotherapy drugs, including cisplatin, are crucial in clinical anti‐cancer treatment. However, these drugs have limitations such as drug resistance, non‐specific distribution, and irreversible toxic and side effects. In recent years, the development of metal‐based agents has led to the discovery of other anti‐cancer effects beyond chemotherapy. Precise spatiotemporal controlled external irradiation can activate metal‐based agents at specific sites and play a different role from traditional chemotherapy. These strategies can not only enhance the anti‐cancer efficiency, but also show fewer side effects and non‐cross‐drug resistance, which are ideal approaches to solve the problems caused by traditional platinum‐based chemotherapy drugs. In this review, we focus on various metal‐based agent‐mediated cancer therapies that are activated by three types of external irradiation: near‐infrared (NIR) light, ultrasound (US), and X‐ray, and give some prospects. We hope that this review will promote the generation of new kinds of metal‐based anti‐cancer agents.
Design of Knölker‐Type Catalysts for the Anomeric Oxidation of Unprotected Mono‐ and Disaccharides
Authors: Bandyopadhyay Uchchhal , Lancien Antoine , Branquet David , Lhoste Jérôme , Comesse Sébastien , Martel Arnaud , Benhamou Laure 
Published: June 2024

AbstractKnölker complexes have been recently used to perform the catalytic C1‐oxidation of unprotected sugars into sugar lactones. This oxidation method remained limited by the stability of the catalyst with the polyhydroxylated substrates. Our objective is now to overcome these limitations and extend this method to more challenging substrates such as disaccharides. We proposed in this paper two original designs of Knölker‐type complexes conceived to promote secondary H‐bond interactions with the OH groups of the substrates to stabilise the system and favour the transformation. In total, 8 novel pre‐catalysts were synthesised, fully characterised and applied in the anomeric oxidation of several sugar derivatives. Two of these new complexes proved to be more efficient than the Knölker complex for the oxidation of disaccharides. Moreover, a preliminary DFT study revealed the presence of H‐bonds interactions between the substrate and the oxygen atom on the ligand arm of the best complexes suggesting a beneficial role of this heteroatom on the catalytic efficiency.