bluuebunny/crossref_metadata_2025_split huggingface dataset:
NMR line shapes from AB spin systems in solids — The role of antisymmetric spin–spin coupling
Authors: Harris Kristopher J. , Bryce David L. , Wasylishen Roderick E. 
Published: October 2009

NMR parameters such as indirect nuclear spin–spin coupling (J), nuclear magnetic shielding (σ), direct dipolar coupling (D), and electric field gradient (V) are properly described by second-rank tensors. Each may be decomposed into isotropic, symmetric, and antisymmetric components; the number of these three components which may be nonzero is a distinguishing attribute of each interaction tensor. The rank-1 antisymmetric portion of J (Janti) holds the distinction of remaining the only nonzero part of these fundamental NMR interaction tensors which has never been observed experimentally. Accordingly, effects from Janti are usually ignored, but it is important to consider when this is valid. An experimental strategy for observing Janti in powdered samples of tightly coupled homonuclear spin pairs, based on ideas originally presented by Andrew and Farnell ( Mol. Phys. 1968, 15, 157 ), is described. The theory of Andrew and Farnell is extended to powder samples, and methods for analyzing NMR spectra from powdered samples are presented. It is found that, in certain rare cases, Janti has the potential to affect the NMR line shapes from AB spin systems, but that even in these systems, the most intense features of the spectra are not affected and may be analyzed independently of Janti. Furthermore, Janti will only have an observable effect on the NMR spectra when its magnitude is comparable with that of Jiso and with the difference in chemical shifts (in Hz) between the two sites. Finally, the first experimental attempts to measure Janti are reported, and experimental proof that no elements of Janti(119Sn,119Sn) in hexa(p-tolyl)ditin are larger than 2900 Hz is given. The benefits of modern double-quantum filtering NMR pulse sequences in isolating effects from Janti are also illustrated.
Neptunium(VII) in high-ionic-strength alkaline solutions — [NpO2(OH)4]1– or [NpO4(OH)2]3–?
Authors: Wren John E. C. , Schreckenbach Georg 
Published: October 2009

Relativistic density functional theory (ZORA-PBE, COSMO solvation) is used to address the title question, based on comparison with recent experimental data ( 1 ). Structural data (bond lengths), vibrational frequencies, and 17O NMR chemical shifts are used to prove that [NpO4(OH)2]3– is the predominant species in high-ionic-strength alkaline solutions of NpVII. Neptunium(VII) complexes have stronger bonds than their formally isoelectronic uranium(VI) analogues. The experimentally observed 300 ppm shift in 17O chemical shifts between the known [UO2(OH)4]2– and NpVII solution is shown to be partly a function of the central metal (NpVII vs. UVI) and not of the coordination environment (tetraoxo vs. dioxo). Comparing, for a given An (UVI or NpVII), actinyl complexes [AnO2X4]2–/1–, X = Cl, F, OH, a decreasing strength of the axial actinyl bond is observed that is traced to electronic factors (equatorial π-competition).
The Dewar–Chatt–Duncanson model reversed — Bonding analysis of group-10 complexes [(PMe3)2M–EX3] (M = Ni, Pd, Pt; E = B, Al, Ga, In, Tl; X = H, F, Cl, Br, I)
Authors: Goedecke Catharina , Hillebrecht Pierre , Uhlemann Till , Haunschild Robin , Frenking Gernot 
Published: October 2009

Quantum chemical calculations using BP86 with TZ2P basis sets were carried out to elucidate the structures and the bond–bond dissociation energies of the donor–acceptor complexes [(PMe3)2M–EX3] with X = H, F, Cl, Br, I; E = B, Al, Ga, In, Tl; and M = Ni, Pd, Pt. The nature of the metal–ligand bond was investigated with an energy decomposition analysis. The geometry optimizations gave for most compounds T-shaped structures with nearly linear P–M–P angles where the EX3 ligand has either a staggered or eclipsed conformation with respect to the PMP plane. The energy differences between the conformations are very small which means that there is nearly free rotation about the M–EX3 axis. The equilibrium structures of eight nickel compounds have a distorted geometry where one E–X bond is engaged in attractive interactions with the metal atom which yields a distorted square-planar arrangement of the metal atom. The complex [(PMe3)2Ni–TlI3] exhibits two attractive interactions between Tl–I bonds and the metal which features a five-coordinated metal atom. The calculated bond dissociation energies show that the boron complexes exhibit a different trend for the De values than the heavier group-13 homologues. The results for the Pd and Pt complexes suggest that the [(PMe3)2M–BX3] bond strength increases with F < Cl < Br < I < H which means that the BH3 ligands are the most strongly bonded Lewis acids and BF3 is the most weakly bonded species . The trend for the heavier group-13 complexes [(PMe3)2M–EX3] where E = Al, Ga, In, Tl follows the opposite order F > Cl > Br > I > H. The energy decomposition analysis of the M–EX3 bonds indicates a substantial π contribution of between 12.7% and 30.3% to the total orbital interactions. There is no direct correlation between the strength of the orbital interactions or any of the other energy terms ΔEelstat or ΔEPauli which correlates with the total interaction energy. The bond dissociation energy of the EX3 ligands after breaking the M–EX3 bonds is quite large. It is shown that the intrinsic strength of the M–EX3 bonds is much larger than the BDEs and that the trends of ΔEint and De are not always the same. The EX3 ligands in [(PMe3)2M–BX3] always carry a large negative charge.
Interspecific variation in leaf litter production, decomposition, and nitrogen and phosphorus loss from decomposing leaves in a humid subtropical forest ecosystem of northeastern India
Authors: Kamei Jenpuiru , Barik S. K. , Pandey H. N. 
Published: October 2009

Studies providing direct experimental evidence of species impact on litter dynamics in forest ecosystems are limited. The decomposition processes in subtropical forests are also poorly understood. We studied variation in quality and quantity of leaf litter production, decomposition, and N and P loss from decomposing foliar litter in three tree species as well as a mixed-species plot in a subtropical broad-leaved forest of northeastern India. The annual leaf litter production was highest in Rhododendron arboreum Sm. (7293 kg·ha–1·year–1) followed by Myrica esculenta Buch.-Ham. ex D. Don (6902 kg·ha–1·year–1), mixed plots (6808 kg·ha–1·year–1), and Neolitsea cassia (L.) Kosterm (6299 kg·ha–1·year–1). The annual N and P inputs through litter were highest in the mixed plot (N, 111.0 kg·ha–1·year–1; P, 4.8 kg·ha–1·year–1) and lowest in the Rhododendron plot (N, 65.6 kg·ha–1·year–1; P, 2.9 kg·ha–1·year–1). The highest decay rate was recorded for Neolitsea (k = 0.89) and lowest for Myrica (k = 0.53) litter. The rate of N loss was highest for Neolitsea (kN= 1.39) and lowest for Myrica (kN= 0.68) species, and P loss was in the order of mixed (kP= 1.02) > Neolitsea (kP= 0.88) > Rhododendron(kP= 0.84) > Myrica (kP= 0.62). Acid-insoluble residue, which indicates lignin content and P-related litter chemistry, were correlated with the differential decomposition rates and nutrient loss pattern among the species.
Succession of bryophyte assemblages following clear-cut logging in boreal spruce-dominated forests in south-central Sweden — Does retrogressive succession occur?
Authors: Schmalholz Martin , Hylander Kristoffer 
Published: October 2009

The recovery process of boreal bryophyte communities after clear-cutting was studied in a chronosequence in south-central Sweden. We hypothesized that high initial grass cover on clearcuts, high litter cover and low light levels during canopy closure, and shortage of coarse woody substrates would constrain recovery in different ways. Instead, both epigeic and epixylic guilds (i.e., species growing on forest floor and deadwood) displayed a gradual increase in similarity over time from the clear-cut phase, perhaps because of the absence of distinct peaks in needle litter and canopy cover. Epixylic species started to recover long before the accumulation of deadwood, indicating that microclimate rather than substrate availability was the most constraining factor during the first 50 years. Since we did not find any other bottlenecks during the succession after clear-cutting, conservation measures aiming at decreasing local extinction rates during clear-cutting may also increase long-term persistence. On the other hand, as the results from the epixylic guild suggest, other factors during the forest succession, such as the development of a suitable microclimate, might be more important for some organisms, thus possibly mitigating such long-term positive effects of adjusted management during the clear-cutting operation.
Assessing the climatic potential for epizootics of the gypsy moth fungal pathogen Entomophaga maimaiga in the North Central United States
Authors: Siegert Nathan W. , McCullough Deborah G. , Venette Robert C. , Hajek Ann E. , Andresen Jeffrey A. 
Published: October 2009

The fungal pathogen Entomophaga maimaiga Humber, Shimazu et Soper has become an important biocontrol for gypsy moth ( Lymantria dispar (L.)) in the northeastern United States and is commonly introduced into new areas with established gypsy moth populations. Germination of the fungus is dependent on spring temperature and moisture, but specific conditions associated with epizootics have not been determined. Whether E. maimaiga will be as effective in other regions that experience different weather conditions is not yet known. We examined similarity of weather conditions associated with 16 documented E. maimaiga epizootics with conditions at 1351 North American locations using the climate-matching software CLIMEX. Based on CLIMEX’s overall index of climatic similarity, long-term annual climatic patterns across much of the eastern United States were 60%–80% similar to the conditions associated with epizootics. Monthly weather records from 1971 to 2000 in nine North Central states were examined to compare precipitation and temperature with conditions observed during epizootics. Based on climatic averages identified with the documented epizootics, temperature and precipitation conditions in Illinois, Indiana, Iowa, Kentucky, Missouri, and Ohio were more conducive for epizootics than conditions in Minnesota, Wisconsin, and Michigan, which were likely to support E. maimaiga epizootics in fewer than 6 of the 30 years considered.
Dying old in the 21st century
Authors: Holloway Margaret 
Published: October 2009

English Dying in old age has become the majority dying of the developed world, yet older people are routinely denied palliative care, their dying characterized by failure to facilitate choice and recognize their needs. Social workers in all settings should embrace their contribution to quality end-of-life care for older people. French Mourir à un âge avancé est devenu la ‘forme majoritaire de la mort’ dans le monde développé, bien que l’on dénie couramment aux personnes âgées l’accès aux soins palliatifs, leur décès étant socialement caractérisé par l’incapacité à faciliter leurs choix et à reconnaître leurs besoins. Les travailleurs sociaux dans tous les dispositifs devraient apporter leur contribution à la qualité des soins de fin de vie pour les personnes âgées. Spanish Morirse de viejo se ha convertido en la forma mayoritaria de morir en el mundo desarrollado, sin embargo, a los ancianos se les niega sistemáticamente el cuidado paliativo. Sus muertes se caracterizan por el fallo de no ofrecer a los ancianos opciones y reconocer sus necesidades. Los trabajadores sociales de todas partes deben contribuir a la calidad del cuidado al final de la vida de los ancianos.
Facilitating the development of social work in the Hashemite Kingdom of Jordan
Authors: Cocks Alison J. , Al-Makhamreh Sahar S. , Abuieta Siham , Alaedein Jehad , Forrester Donald , Sullivan Mary Pat 
Published: October 2009

English This article reports on a collaboration between Jordan and the UK to develop social work as a profession in Jordan. Reflecting on some of the less anticipated outcomes of the project and the mutual benefits of engaging with cross-cultural alliances, the article is contextualized within debates around post-colonialism and the indigenization of practice. French Cet article présente une collaboration jordano-britannique visant le développement de la profession du travail social en Jordanie. Il apporte une réflexion sur certains des résultats les plus inattendus du projet ainsi que sur les bienfaits retirés de part et d’autre de cette alliance interculturelle. La présente réflexion se situe dans le contexte d’un débat touchant le post-colonialisme et l’adaptation des pratiques aux différents milieux d’exercice. Spanish Se informa sobre una colaboración entre Jordania y el Reino Unido en el desarrollo profesional del trabajo social. Se reflexiona sobre algunas consecuencias del proyecto que no fueron anticipadas, así como los beneficios mutuos de crear alianzas culturales. El ensayo toma en consideración el contexto de los debates acerca del post-colonialismo y las prácticas indígenas.
Comprehensive genomic screens identify a role for PLZF-RARα as a positive regulator of cell proliferation via direct regulation of c-MYC
Authors: Rice Kim L. , Hormaeche Itsaso , Doulatov Sergei , Flatow Jared M. , Grimwade David , Mills Ken I. , Leiva Magdalena , Ablain Julien , Ambardekar Charuta , McConnell Melanie J. , Dick John E. , Licht Jonathan D. 
Published: October 2009

Abstract
The t(11;17)(q23;q21) translocation is associated with a retinoic acid (RA)–insensitive form of acute promyelocytic leukemia (APL), involving the production of reciprocal fusion proteins, promyelocytic leukemia zinc finger–retinoic acid receptor α (PLZF-RARα) and RARα-PLZF. Using a combination of chromatin immunoprecipitation promotor arrays (ChIP-chip) and gene expression profiling, we identify novel, direct target genes of PLZF-RARα that tend to be repressed in APL compared with other myeloid leukemias, supporting the role of PLZF-RARα as an aberrant repressor in APL. In primary murine hematopoietic progenitors, PLZF-RARα promotes cell growth, and represses Dusp6 and Cdkn2d, while inducing c-Myc expression, consistent with its role in leukemogenesis. PLZF-RARα binds to a region of the c-MYC promoter overlapping a functional PLZF site and antagonizes PLZF-mediated repression, suggesting that PLZF-RARα may act as a dominant-negative version of PLZF by affecting the regulation of shared targets. RA induced the differentiation of PLZF-RARα–transformed murine hematopoietic cells and reduced the frequency of clonogenic progenitors, concomitant with c-Myc down-regulation. Surviving RA-treated cells retained the ability to be replated and this was associated with sustained c-Myc expression and repression of Dusp6, suggesting a role for these genes in maintaining a self-renewal pathway triggered by PLZF-RARα.
MicroRNA 29b functions in acute myeloid leukemia
Authors: Garzon Ramiro , Heaphy Catherine E. A. , Havelange Violaine , Fabbri Muller , Volinia Stefano , Tsao Twee , Zanesi Nicola , Kornblau Steven M. , Marcucci Guido , Calin George A. , Andreeff Michael , Croce Carlo M. 
Published: October 2009

AbstractMicroRNAs (miRNAs) are associated with cytogenetics and molecular subtypes of acute myelogeneous leukemia (AML), but their impact on AML pathogenesis is poorly understood. We have previously shown that miR-29b expression is deregulated in primary AML blasts. In this work, we investigated the functional role of miR-29b in leukemogenesis. Restoration of miR-29b in AML cell lines and primary samples induces apoptosis and dramatically reduces tumorigenicity in a xenograft leukemia model. Transcriptome analysis after ectopic transfection of synthetic miR-29b into leukemia cells indicates that miR-29b target apoptosis, cell cycle, and proliferation pathways. A significant enrichment for apoptosis genes, including MCL-1, was found among the mRNAs inversely correlated with miR-29b expression in 45 primary AML samples. Together, the data support a tumor suppressor role for miR-29 and provide a rationale for the use of synthetic miR-29b oligonucleotides as a novel strategy to improve treatment response in AML.
How I treat CLL up front
Authors: Gribben John G. 
Published: October 2009

AbstractAlthough chronic lymphocytic leukemia (CLL) remains incurable, over the past decade there have been major advances in understanding the pathophysiology of CLL and in the treatment of this disease. This has led to greatly increased response rates and durations of response but not yet improved survival. Advances in the use of prognostic factors that identify patients at high risk for progression have led us to the question whether there is still a role for a “watch and wait” approach in asymptomatic high-risk patients or whether they should be treated earlier in their disease course. Questions remain, including, what is the optimal first-line treatment and its timing and is there any role of maintenance therapy or stem cell transplantation in this disease? CLL is a disease of the elderly and not all patients are eligible for aggressive up-front chemoimmunotherapy regimens, so what is the optimal treatment approach for more frail elderly patients? It is highly likely that our treatment approaches will continue to evolve as the results of ongoing clinical trials are released and that further improvements in the outcome of this disease will result from identification of therapies that target the underlying pathophysiology of CLL.
Nme protein family evolutionary history, a vertebrate perspective
Authors: Desvignes Thomas , Pontarotti Pierre , Fauvel Christian , Bobe Julien 
Published: October 2009

Abstract

Background
The Nme family, previously known as Nm23 or NDPK, is involved in various molecular processes including tumor metastasis and some members of the family, but not all, exhibit a Nucleoside Diphosphate Kinase (NDPK) activity. Ten genes are known in humans, in which some members have been extensively studied. In non-mammalian species, the Nme protein family has received, in contrast, far less attention. The picture of the vertebrate Nme family remains thus incomplete and orthology relationships with mammalian counterparts were only partially characterized. The present study therefore aimed at characterizing the Nme gene repertoire in vertebrates with special interest for teleosts, and providing a comprehensive overview of the Nme gene family evolutionary history in vertebrates.

Results
In the present study, we present the evolutionary history of the Nme family in vertebrates and characterize the gene family repertoire for the first time in several non-mammalian species. Our observations show that vertebrate Nme genes can be separated in two evolutionary distinct groups. Nme1, Nme2, Nme3, and Nme4 belong to Group I while vertebrate Nme5, Nme6, Nme7, Nme8, and Nme9 belong to Group II. The position of Nme10 is in contrast more debatable due to its very specific evolutionary history. The present study clearly indicates that Nme5, Nme6, Nme7, and Nme8 originate from duplication events that occurred before the chordate radiation. In contrast, Nme genes of the Group I have a very different evolutionary history as our results suggest that they all arise from a common gene present in the chordate ancestor. In addition, expression patterns of all zebrafish nme transcripts were studied in a broad range of tissues by quantitative PCR and discussed in the light of the function of their mammalian counterparts.

Conclusion
This work offers an evolutionary framework that will pave the way for future studies on vertebrate Nme proteins and provides a unified vertebrate Nme nomenclature that is consistent with the nomenclature in use in mammals. Based on protein structure and expression data, we also provide new insight into molecular functions of Nme proteins among vertebrates and raise intriguing questions on the roles of Nme proteins in gonads.
Acute sensorineural hearing loss and severe otalgia due to scrub typhus
Authors: Kang Ji-In , Kim Dong-Min , Lee Joonhan 
Published: October 2009

Abstract

Background
Scrub typhus is an acute febrile illness caused by Orientia tsutsugamushi.

Case presentations
We encountered a patient with sensorineural hearing loss complicating scrub typhus, and three patients with scrub typhus who complained of otalgia, which was sudden onset, severe, paroxysmal, intermittent yet persistent pain lasting for several seconds, appeared within 1 week after the onset of fever and rash. The acute sensorineural hearing loss and otalgia were resolved after antibiotic administration.

Conclusion
When patients in endemic areas present with fever and rash and have sensorineural hearing loss or otalgia without otoscopic abnormalities, clinicians should suspect scrub typhus and consider empirical antibiotic therapy.
Expression profiling identifies genes involved in neoplastic transformation of serous ovarian cancer
Authors: Merritt Melissa A , Parsons Peter G , Newton Tanya R , Martyn Adam C , Webb Penelope M , Green Adèle C , Papadimos David J , Boyle Glen M 
Published: October 2009

Abstract

Background
The malignant potential of serous ovarian tumors, the most common ovarian tumor subtype, varies from benign to low malignant potential (LMP) tumors to frankly invasive cancers. Given the uncertainty about the relationship between these different forms, we compared their patterns of gene expression.

Methods
Expression profiling was carried out on samples of 7 benign, 7 LMP and 28 invasive (moderate and poorly differentiated) serous tumors and four whole normal ovaries using oligonucleotide microarrays representing over 21,000 genes.

Results
We identified 311 transcripts that distinguished invasive from benign tumors, and 20 transcripts that were significantly differentially expressed between invasive and LMP tumors at p < 0.01 (with multiple testing correction). Five genes that were differentially expressed between invasive and either benign or normal tissues were validated by real time PCR in an independent panel of 46 serous tumors (4 benign, 7 LMP, 35 invasive). Overexpression of SLPI and WNT7A and down-regulation of C6orf31, PDGFRA and GLTSCR2 were measured in invasive and LMP compared with benign and normal tissues. Over-expression of WNT7A in an ovarian cancer cell line led to increased migration and invasive capacity.

Conclusion
These results highlight several genes that may play an important role across the spectrum of serous ovarian tumorigenesis.
Inhibition of succinate dehydrogenase dysregulates histone modification in mammalian cells
Authors: Cervera Ana M , Bayley Jean-Pierre , Devilee Peter , McCreath Kenneth J 
Published: October 2009

Abstract
Remodelling of mitochondrial metabolism is a hallmark of cancer. Mutations in the genes encoding succinate dehydrogenase (SDH), a key Krebs cycle component, are associated with hereditary predisposition to pheochromocytoma and paraganglioma, through mechanisms which are largely unknown. Recently, the jumonji-domain histone demethylases have emerged as a novel family of 2-oxoglutarate-dependent chromatin modifiers with credible functions in tumourigenesis. Using pharmacological and siRNA methodologies we show that increased methylation of histone H3 is a general consequence of SDH loss-of-function in cultured mammalian cells and can be reversed by overexpression of the JMJD3 histone demethylase. ChIP analysis revealed that the core promoter of IGFBP7, which encodes a secreted protein upregulated after loss of SDHB, showed decreased occupancy by H3K27me3 in the absence of SDH. Finally, we provide the first evidence that the chief (type I) cell is the major methylated histone-immunoreactive constituent of paraganglioma. These results support the notion that loss of mitochondrial function alters epigenetic processes and might provide a signature methylation mark for paraganglioma.