bluuebunny/crossref_metadata_2025_split huggingface dataset:
Additive Manufacturing of Organic Electrochemical Transistors: Methods, Device Architectures, and Emerging Applications
Authors: Granelli Roberto , Kovács‐Vajna Zsolt M. , Torricelli Fabrizio 
Published: February 2025

AbstractOrganic electrochemical transistors (OECTs) are key devices in a large set of application fields including bioelectronics, neuromorphics, sensing, and flexible electronics. This review explores the advancements in additive manufacturing techniques accounting for printing technologies, device architectures, and emerging applications. The promising applications of printed OECTs, ranging from biochemical sensors to neuromorphic computing are examined, showcasing their versatility. Despite significant advancements, ongoing challenges persist, such as material‐related issues, inconsistencies in film homogeneity, and the scalability of integration processes. This review identifies these critical obstacles and offers targeted solutions and future research directions aimed at enhancing the performance and reliability of fully‐printed OECTs. By addressing these challenges, the aim of this study is to facilitate the development of next‐generation OECTs that can meet the demands of emerging applications in sustainable and intelligent electronic and bioelectronic systems.
Stabilized Extracellular Vesicle Formulations for Inhalable Dry Powder Development
Authors: Jansen Eva M. , van der Koog Luke , Elferink Robin A.B. , Rafie Karim , Nagelkerke Anika , Gosens Reinoud , Frijlink Henderik W. , Hinrichs Wouter L.J. 
Published: February 2025

AbstractChronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide, with a significant impact on low‐ and middle‐income countries, making it a critical challenge for global health equity and sustainable development goals. Extracellular vesicles (EVs) are emerging as a promising treatment for COPD, but conventional storage at −80 °C limits their global accessibility. This study explores alternative storage methods to enhance EV stability and accessibility, particularly in low‐resource settings. EVs from lung fibroblasts are subjected to freezing, freeze drying, and spray drying with inulin or mannitol. The biophysical properties are evaluated by their capacity to support lung organoid formation. Inulin proves effective in stabilizing EVs, maintaining functionality after freezing at −20 °C for 12 weeks. Freeze drying with inulin preserves EV stability at 20 °C and 43% relative humidity. In contrast, EVs with mannitol exhibit aggregation and reduce bio‐functionality. Additionally, spray drying EVs with inulin and leucine produces a dry powder suitable for inhalation, maintaining biophysical properties and functionality for 12 weeks. The powder demonstrates efficient lung deposition using the Cyclops inhaler. These findings suggest inulin as a stabilizer for EVs, eliminating the need for ultra‐low temperature storage and improving the practicality of EV‐based inhalable therapies.
From Dreaming of Freedom to Freedom Dreaming: Developing Students' Abolitionist Praxis Through Interdisciplinary Literacy Instruction
Authors: González Rubén A. , Jones Brittany L. 
Published: February 2025

ABSTRACTThis qualitative study examines how elementary students of Color develop and enact an abolitionist praxis as part of a Freedom Dreaming literacy unit. The analysis of focus‐group interviews elucidates how, after learning about freedom dreaming and the abolition of prisons and police, students positioned historical anti‐carceral activism as something occurring in the present and students leveraged their historical and contemporary understanding of anti‐carceral activism to enact their own freedom dreaming toward abolishing carcerality within their school. Our findings reveal the transformative potential of centering freedom dreaming and the abolition of prisons and police in elementary literacy instruction.
Poorly differentiated soft tissue sarcoma located in the craniodorsal mediastinum in two dogs and a literature review
Authors: Cifre Pallicer Cristina , Di Bella Andrea , Kelly Darren , Shihab Nadia , Karpozilou Athina 
Published: February 2025

AbstractSoft tissue sarcoma represents a heterogeneous group of mesenchymal tumours that arise from connective tissues. Two dogs presented with a single mass located in the craniodorsal aspect of the mediastinum. Radiographs and a computed tomography scan performed in both cases revealed a large craniodorsal mediastinal/paravertebral mass associated with rib lysis and invasion of the vertebral canal. Immunohistochemistry performed on biopsies from the mass in Dog 1 and Dog 2 confirmed a poorly differentiated soft tissue sarcoma. To our knowledge, in the veterinary literature, this is the first report of poorly differentiated soft tissue sarcoma located in the craniodorsal mediastinum. Despite being a rare presentation in both humans and dogs, soft tissue sarcoma should be considered as a differential diagnosis in dogs presenting with a mass in the craniodorsal mediastinum. This case report's purpose is to describe the presence of mediastinal craniodorsal sarcomas and raise awareness of this disease process in dogs.
Firework injuries around New Year’s Eve - epidemiology, injury patterns and risk factors
Authors: Wegmann Helena , Mayer Steffi , Blankenburg Notker , Zimmermann Peter , Schulz Torsten , Lacher Martin , Kleber Christian , Osterhoff Georg 
Published: February 2025

Abstract

Introduction
This study aims to determine key demographic and behavioural risk factors contributing to firework-related injuries and their outcomes.

Methods
A retrospective study was conducted on pediatric and adult patients treated for firework-related injuries at the University Hospital Leipzig from December 28th to January 3rd over 10 years (2013–2023). Data were collected on demographics, injury details, weather conditions and classification of fireworks.

Results
A total of 155 patients (mean age 24 years, 80% male) were included. Injuries predominantly occurred within two hours after midnight, and all incidents involved violation of safety regulations. Most injuries were self-inflicted (48.4%), with hands being the most frequently affected body part (52.9%). Burn injuries were common (43.9%) but were less likely during rainy weather (OR 0.4, 95% CI 0.2–0.7, p = 0.004). Surgical intervention was required in 23.9% of cases, with significant risk factors being associated bone injuries (OR 107.1, 95% CI 22.7 to 505.6), male sex (OR 5.7, 95% CI 1.3–25.0) and multiple body region injuries (OR 4.9, 95% CI 2.1–11.7). Permanent loss of function was observed in 46.5% of all patients.

Conclusion
Firework-related injuries around New Year’s Eve are associated with significant morbidity, particularly affecting the hands and often requiring surgical intervention. Bone injuries, male sex and multiple body region injuries were associated with higher need for surgical treatment. Despite most fireworks being purchased legally, there is widespread disregard to age restrictions and safety protocols. These findings highlight the necessity of public health initiatives to reduce the incidence and severity of such injuries, rather than stricter regulations.
Effectiveness of antibiotic prophylaxis in polytrauma patients: a systematic review and meta-analysis
Authors: Dahms Karolina , Ansems Kelly , Dormann Julia , Steinfeld Eva , Janka Heidrun , Metzendorf Maria-Inti , Breuer Thomas , Benstoem Carina 
Published: February 2025

Abstract

Purpose
The use of antibiotic prophylaxis in trauma patients, particularly to prevent ventilator-associated pneumonia (VAP), is debated due to rising antibiotic resistance. Therefore, this systematic review evaluated the safety and effectiveness of antibiotic prophylaxis compared to placebo or standard care on clinical outcomes in adult polytrauma patients.

Methods
We searched PubMed and the Cochrane Central Register of Controlled Trials to identify completed and ongoing studies from database inception to April 20, 2023. Eligible studies included systematic reviews and randomized controlled trials (RCTs) comparing antibiotic prophylaxis to placebo or standard care in adult polytrauma patients admitted to the intensive care unit (ICU).

Results
Of 1237 identified records, three RCTs involving 256 patients (nantibiotics = 176, ncontrol = 165, mean age 37.4 years, 81.6% male) were included. Antibiotic prophylaxis showed little or no effect on all-cause mortality compared to placebo or standard care (RR 1.01, 95% CI 0.55–1.85; RD 2 more per 1000, 95% CI -79 to 150; 2 studies, 209 participants; I
2 = 0%; very low certainty of evidence).

Conclusion
The results indicate that antibiotic prophylaxis has no significant effect on mortality and clinical status compared with placebo or standard care in adult polytrauma patients but may reduce the risk of VAP. However, the evidence is outdated and of very low certainty, with insufficient data to draw definitive conclusions regarding efficacy. Therefore, high-quality, up-to-date research is urgently needed to support clinical decision-making, and current interpretations should be treated with caution.
Understanding kinesiophobia in pediatric bone tumors: investigating its presence and predictive factors
Authors: Yılmaz Güleser Güney , Tanrıverdi Müberra , Önal Gözde , Yiğit Ayşenur Baysal , Şahin Sedef , Çakır Fatma Betül 
Published: February 2025

Abstract
Primary malignant bone tumors are significant health concerns in children. These tumors, often accompanied by pain, fatigue, and reduced physical function, can lead to the development of kinesiophobia, a fear of movement that can further complicate rehabilitation. Although factors associated with kinesiophobia have been examined in various adult cancer populations, there is limited research on kinesiophobia and its predictors in children with bone tumors. This study aims to investigate the factors contributing to kinesiophobia in pediatric bone tumor patients. This prospective cross-sectional study was conducted in children with primary malignant bone tumors aged 8–17 years who actively on treatment. The Tampa Scale for Kinesiophobia (TSK) was used to assess fear of movement. Other assessments included the numerical rating scale (NRS) for pain, the PedsQL™ Multidimensional Fatigue Scale for fatigue, the Children Depression Rating Scale-Revised (CDRS-R) for depression, manual muscle testing, and the TUG Test for functionality. Logistic regression was performed to identify predictors of kinesiophobia, while chi-square tests examined the relationship between muscle strength and kinesiophobia levels. One hundred children with bone tumors an average age of 11.83 years participated in the study. The logistic regression model indicated that surgery status, pain levels, and fatigue were significant predictors of kinesiophobia, with an R
2 value of 0.870, explaining 87% of the variance in kinesiophobia levels. Children who had surgery and were in more pain and had higher levels of depression were more likely to exhibit kinesiophobia. Conclusion: This study highlights the multifactorial nature of kinesiophobia in children with malignant bone tumors, emphasizing the roles of surgical status, pain, and psychological factors. Integrating biopsychosocial assessments and approaches into routine care may be important to reduce kinesiophobia, improve rehabilitation outcomes, and increase overall well-being.

What is Known:

•
Kinesiophobia has been studied in adult cancer populations and has been associated with decreased physical
activity and poorer rehabilitation outcomes.

What is New:

•
This study demonstrates that surgery status, pain levels, and fatigue are significant predictors of kinesiophobia in children with malignant bone tumors and highlights that, in addition to various cancer-related symptoms, kinesiophobia can also be present in this population.
Suchtproblematik in der spezialisierten ambulanten Palliativversorgung in Deutschland
Authors: Eersink Jannis , Maul Julian , Heuser Nils , Morin Astrid , Gschnell Martin , Volberg Christian 
Published: February 2025

Zusammenfassung

Hintergrund
In der Palliativmedizin steht die Symptomkontrolle der Patienten im Vordergrund. Um dies zu erreichen, werden oft Medikamente eingesetzt, die ein Suchtpotenzial besitzen. Da Patienten in einer palliativen Erkrankungssituation immer länger überleben, kann es hierdurch zu einer Abhängigkeitsproblematik kommen.

Ziele der Arbeit
Diese Studie untersucht, ob in der spezialisierten ambulanten Palliativversorgung (SAPV) Substanzmissbrauch bei Patienten als ein Problem wahrgenommen wird.

Material und Methode
Eine Querschnittserhebung wurde unter allen deutschen SAPV-Diensten (n = 366) mithilfe eines Fragebogens durchgeführt. Die Daten sind deskriptiv ausgewertet worden.

Ergebnisse
129 SAPV-Dienste (35,2 %) nahmen an der Umfrage teil. 49,6 % geben an, dass schätzungsweise 1–5 % ihrer Patienten an einer Medikamentenabhängigkeit leiden, und 65,9 % schätzen, dass 1–5 % ihrer Patienten Drogen konsumieren. 69,8 % der SAPV-Dienste screenen ihre Patienten nicht auf das Vorliegen einer Suchterkrankung, während dies von 3,1 % regelmäßig gemacht wird. Bei Vorliegen einer Suchtproblematik führen 65,9 % der SAPV-Dienste keine Maßnahmen durch.

Diskussion
Laut den vorliegenden Daten wird Abhängigkeit nicht als Problem in der Palliativmedizin gesehen. Hier ist jedoch einzuschränken, dass fast kein SAPV-Dienst Patienten auf das Vorliegen einer Abhängigkeit screent, obwohl über die Hälfte schätzen, dass zumindest ein Teil der Patienten ein Suchtproblem aufweist. Hier ist in der Zukunft weitere Forschung notwendig, denn durch neue Therapien können Patienten in palliativen Situationen länger leben. Es wäre für die Weiterentwicklung der Palliativmedizin und die Lebensqualität der Betroffenen wichtig zu evaluieren, wie Patienten vor iatrogen induziertem Substanzmissbrauch geschützt werden können.
The tiny-leaved orchid Disperis neilgherrensis primarily obtains carbon from decaying litter via saprotrophic Ceratobasidium
Authors: Suetsugu Kenji , Yagi Ryuta , Okada Hidehito , Matsubayashi Jun 
Published: February 2025

Abstract
While most green orchids establish associations with non-ectomycorrhizal rhizoctonias belonging to Ceratobasidiaceae, Tulasnellaceae, and Serendipitaceae, fully mycoheterotrophic orchids—excluding albino mutants—primarily depend on either ectomycorrhizal fungi or saprotrophic non-rhizoctonia fungi. This suggests that non-ectomycorrhizal rhizoctonias may be unable to meet the carbon demands of adult orchids that exhibit a high degree of mycoheterotrophy. To understand the physiological ecology of Disperis neilgherrensis, an orchid species with reduced leaves growing in decaying litter from non-ectomycorrhizal trees, we employed molecular and stable isotope analyses to identify its mycorrhizal partners and ultimate nutritional sources at two populations on Ishigaki Island, Japan. Molecular barcoding techniques revealed that D. neilgherrensis forms exclusive associations with non-ectomycorrhizal Ceratobasidiaceae fungi. The Disperis specimens exhibited δ13C and δ15N isotopic values similar to those found in fully mycoheterotrophic orchids that exploit litter-decaying fungi. Furthermore, the pelotons of D. neilgherrensis showed significantly elevated δ13C values similar to saprotrophic non-rhizoctonia fungi. Our findings indicate that D. neilgherrensis primarily obtains its carbon from decaying litter through a specialized relationship with non-ECM Ceratobasidiaceae. Given that saprotrophic Ceratobasidiaceae facilitate nearly fully mycoheterotrophic growth in D. neilgherrensis, at least under warm and humid conditions, it is plausible that other (nearly) fully mycoheterotrophic tropical orchids also meet their carbon requirements through associations with saprotrophic rhizoctonias.
Comparison of the 2-year clinical performances of class II restorations using different restorative materials
Authors: Hançer Sarıca Sevim , Arslan Soley , Balkaya Hacer 
Published: February 2025

Abstract

Objective
This prospective clinical study aimed to evaluate the two-year clinical performance of conventional composite, bulk-fill composite, and high-filler flowable composite in Class II cavities.

Materials and methods
A total of 259 Class II restorations were performed in 110 patients, applying Clearfil Majesty Posterior (Clearfil) as the conventional composite, Filtek One Bulk Fill Restorative (Filtek) as the bulk-fill composite, and G-aenial Universal Injectable (G-aenial) as the high-fill flowable composite. G-Premio Bond, a universal adhesive system, was applied for all composite resin restorations. Restorations were evaluated using FDI criteria after 2 years. Data were analyzed using the Kruskal-Wallis and Friedman tests.

Results
At the end of two years, the group treated with Clearfil has showed a significantly higher surface gloss score compared to the G-aenial and Filtek groups. Additionally, it was seen that the marginal adaptation scores of the Clearfil group were similar to the Filtek group and significantly higher than the G-aenial group. In intra-group evaluations, the contact point scores of the Clearfil group showed a statistically significant increase compared to baseline and one-year follow-up assessments. The marginal adaptation scores of the Clearfil and Filtek groups also exhibited a statistically significant increase compared to baseline and one-year follow-up assessments.

Conclusions
High-filler flowable composite and bulk-fill composite exhibited better clinical properties regarding surface gloss compared to conventional composite. It was observed that the marginal adaptation property of the conventional composite were similar to the bulk-fill composite and lower than the high- filler flowable composite.

Clinical relevance
: The composite resins tested showed similar results in most of the scores evaluated.
Bridging East and West: How Business Schools Can Develop Responsible Leader Competencies
Authors: Trevisan Tatiana Donato , Haski-Leventhal Debbie , Bankins Sarah 
Published: February 2025

Abstract
Business schools increasingly aim to develop responsible leaders and leadership, yet the literature on how to do this effectively remains limited. Furthermore, existing research is dominated by Western theories and cases, marginalizing non-Western insights for leadership development scholarship and practice. By engaging in construct infusion and integrating insights from Western constructive development theory and Eastern Vedanta philosophy, we diversify this literature to analyze how one business school in India (SPJIMR) develops responsible leadership and associated competencies through its unique pre-experience MBA curriculum. Utilizing an in-depth case study, we show that SPJIMR provided the “holding environment” and meaningful, disequilibrating experiences for students to change their schemas (mental models) and develop intrapersonal, interpersonal, and (the novel) societal competencies, all required for responsible leadership. We also posit the concept of an “internal environment”—the space for self-reflection and new ideas and perspectives necessary for schema changes and personal growth. Our development of the Responsible Leader and Leadership Development Model offers a roadmap to support business schools in developing students’ responsible leadership and to guide future research.
Is Boredom the Opposite of Interest? A Longitudinal Reciprocal Effect Study
Authors: Boehme Katharina Luisa , Goetz Thomas , Feuchter Markus , Preckel Franzis 
Published: February 2025

Abstract
After decades of being conceptualised solely as a lack of interest, boredom has recently gained attention as an important construct in its own right. However, there is still a lack of studies focusing on the relations and developmental interplay of these two closely related constructs. This study examines the overall long-term developmental structure and interplay of students’ boredom and interest in the school domains of mathematics and German from fifth to eighth grade. We investigated German secondary school students (N = 1471) over four waves of measurement, using self-report questionnaires. Confirmatory factor analyses in preparation to the longitudinal approach revealed a significantly better fit for two- vs. one-factor models, indicating an empirical separability of boredom and interest. This was further supported by different stabilities in our latent cross-lagged models with low autoregressive paths for boredom and high paths for interest. The latent cross-lagged models also revealed that higher levels of earlier interest were related to lower levels of later boredom. Surprisingly, individuals with higher boredom scores relative to others on average increased in their interest from the second time point onwards. Findings were robust for German and mathematics. Overall, the results show that while boredom and interest have a large phenomenological overlap, they are empirically separable constructs with different levels of stability and influence each other in a distinctive manner throughout their developmental interplay. Implications for research and practice are outlined.
The Cryogenic System of the MISTRAL Instrument: Design and In-lab Performance
Authors: Coppolecchia A. , Carbone A. , D’ Alessandro G. , Barbavara E. , Battistelli E. S. , de Bernardis P. , Cacciotti F. , Capalbo V. , Carretti E. , Ciccalotti D. , Columbro F. , Cruciani A. , De Petris M. , Govoni F. , Isopi G. , Lamagna L. , Levati E. , Marongiu P. , Mascia A. , Masi S. , Molinari E. , Murgia M. , Navarrini A. , Novelli A. , Occhiuzzi A. , Orlati A. , Paiella A. , Pappalardo E. , Pettinari G. , Piacentini F. , Pisanu T. , Poppi S. , Porceddu I. , Ritacco A. , Schirru M. R. , Vargiu G. 
Published: February 2025

Abstract
We describe the design and performance of the cryostat and the multi-stage sub-K single-shot sorption cooler for the MIllimeter Sardinia Radio Telescope Receiver based on Array of Lumped elements kids (MISTRAL) experiment. MISTRAL is a W-band (77 - 103 GHz) Ti/Al bi-layer Lumped Elements Kinetic Inductance Detectors (LEKIDs) camera working at the Gregorian focus of the 64 m aperture Sardinia Radio Telescope (SRT), located in Sardinia (Italy). The cryogenic system, based on a 1.5 W at 4.2 K Pulse Tube (PT) cryocooler, provides the 4 K base temperature for the sub-K refrigerator, and cools down the cold optics and the filters chain of the instrument. The sub-K sorption cooler consists of two intermediate stages,

$$^{4}$$

4

He and

$$^{3}$$

3

He sorption refrigerators that allow to reduce the heat load on the ultra-cold head, and a twin stage of

$$^{3}$$

3

He sorption refrigerator providing the 0.2 K operation temperature for the 415-pixel array of LEKIDs. MISTRAL experiment was installed at SRT in May 2023, the technical commissioning started in June 2023. We will show the performance of the system in the laboratory.