bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quo vadis ureagenesis disorders? A journey from 90 years ago into the future
Authors: Häberle Johannes , Siri Barbara , Dionisi‐Vici Carlo 
Published: June 2024

AbstractThe pathway of ammonia disposal in the mammalian organism has been described in 1932 as a metabolic cycle present in the liver in different compartments. In 1958, the first human disorder affecting this pathway was described as a genetic condition leading to cognitive impairment and constant abnormalities of amino acid metabolism. Since then, defects in all enzymes and transporters of the urea cycle have been described, referring to them as primary urea cycle disorders causing primary hyperammonemia. In addition, there is a still increasing list of conditions that impact on the function of the urea cycle by various mechanisms, hereby leading to secondary hyperammonemia. Despite great advances in understanding the molecular background and the biochemical specificities of both primary and secondary hyperammonemias, there remain many open questions: we do not fully understand the pathophysiology in many of the conditions; we do not always understand the highly variable clinical course of affected patients; we clearly appreciate the need for novel and improved diagnostic and therapeutic approaches. This study does look back to the beginning of the urea cycle (hi)story, briefly describes the journey through past decades, hereby illustrating advancements and knowledge gaps, and gives examples for the extremely broad perspective imminent to some of the defects of ureagenesis and allied conditions.
The effect of an antioxidant gel compared to chlorhexidine during the soft tissue healing process: An animal study
Authors: Ukaegbu Kelechi , Foyle Deborah , Luan Xianghong , Schneiderman Emet , Allen Edward P. , Plemons Jacqueline , Svoboda Kathy K. H. 
Published: June 2024

AbstractBackgroundProlonged inflammation and oxidative stress can impede healing. To enhance healing efficiency, many solutions have been employed. This is an in vivo study comparing chlorhexidine (CHX) to a commercial antioxidant gel (AO).MethodsEnvelope flaps were created in the lower incisor gingival region of 60 Sprague–Dawley rats, and acellular dermal matrix (ADM) was inserted. Animals were randomly assigned to postsurgical treatment application of AO gel or 0.12% CHX twice daily. A control group received no postsurgical treatment. Data collected (before surgery, 24 h, and 72 h) included surgical images, tissue samples, and weights. Blinded scorers assessed images using a wound healing scale. Real‐time polymerase chain reaction (RT‐PCR) was used for gene expression of tumor necrosis factor‐alpha (TNFα), interleukin‐1 (IL‐1), myeloperoxidase (MPO), and superoxide dismutase (SOD).ResultsThe AO group scored higher than the CHX and control groups in clinical evaluation (p < 0.05). At 24 h, TNFα expression was upregulated in the AO group compared to CHX (p = 0.027) and controls (p = 0.018). The AO group had significantly higher expression of antioxidant enzyme (SOD) at 24 h compared to CHX (p = 0.021). All animals lost weight in the first 24 h. Animals treated with AO or CHX regained more weight at 72 h than control animals (p = 0.034 and 0.003, respectively).ConclusionAnimals treated with AO healed faster. AO led to earlier upregulation of TNFα and antioxidant enzyme SOD. We hypothesized that AO promoted an earlier inflammatory process while counteracting oxidative stress by increasing antioxidant responses via SOD.
Global trends and hotspots on recurrent respiratory papillomatosis: A 20‐year bibliometric analysis
Authors: Wang Chao , Pan Yufei , Huang Huili , Liu Kai , Yu Zhenkun 
Published: June 2024

AbstractObjectivesRecurrent respiratory papillomatosis (RRP) is the most common benign laryngeal tumor in children. It can cause serious psychological and mental burden on patients since RRP requires repeated surgical treatment. This study aims to delineate the global trends and identify hotspots related to RRP over the past two decades.MethodsWe systematically gathered research findings on RRP from 2004 to 2023, utilizing the Web of Science as our data source. Subsequently, we performed a comprehensive bibliometric analysis of the literature using Vosviewer, CiteSpace, and Bibliometrics online analysis platform.ResultsA total of 839 publications were finally identified on RRP from 2004 to 2023. The United States has the largest number of publications (392), accounting for 46.7%. The Capital Medical University is the most productive organization (24), followed by the Centers for Disease Control and Prevention (18). The most productive journal was the Laryngoscope, with 86 publicatios. Comparatively, Vaccine is the most cited journal (2297). Craig S. Derkay ranked highest among all authors in publication (16). Burst detection shows onset, adjuvant therapy, management, juvenile‐onset RRP, systemic bevacizumab, avastin, human papillomavirus vaccine are recent keywords of great interest to researchers.ConclusionResearch on RRP has progressed significantly over the past two decades, especially in terms of therapeutic strategies. We strongly believe that this article will provide new research directions for other researchers and may contribute to future breakthroughs in the field.
Vortex‐Vector Beam Conversion and Chiral Field Manipulation based on Terahertz Liquid Crystal Cascaded Metadevice
Authors: Zhao Huijun , Fan Fei , Wang Yiming , Liu Jing , Ji Yunyun , Cheng Jierong , Chang Shengjiang 
Published: June 2024

AbstractVortex‐vector beam generators can effectively improve the channel capacity and communication accuracy, but they face the problems of narrow operating frequency band, low efficiency, and fixed function. Here, a terahertz liquid crystal cascaded metadevice is demonstrated, including a liquid crystal layer, an asymmetric metasurface layer, and a helical phase metasurface layer. The combination of liquid crystal's anisotropy and structural anisotropy from the asymmetric metasurface realizes the dynamic chirality construction. Then, the tunable chiral fields are effectively coupled with the helical geometric phase of the last metasurface layer to realize an active control between symmetric and asymmetric spin‐orbit angular momentum coupling, leading to the two types of beam generation and conversion: 1) spin‐dependent conversion and energy distribution between the vortex beams with ±2 topological charges; 2) the conversions between the 2‐order vortex beam and the cylindrical vector beam. The experimental results show that the excitation efficiency of vortex beams can reach over 92.1%, and the intensity modulation depth between different types of beams is more than 72.4%. This THz beam dynamic conversion mechanism and device scheme increase the degree of freedom of the device and have potential applications in terahertz multi‐channel wireless communication, polarization multiplexing imaging, and chiral spectrum detection.
Price regulation, network externality, and product innovation strategies: A dynamic analysis
Authors: Ge Lijia , Li Shoude 
Published: June 2024

AbstractFor many high‐tech and Internet‐related products, consumers' utility depends partly on the scale of user groups, which is called network externality. This phenomenon plays a crucial role in shaping firms' innovation strategies, especially in markets with price regulation. This paper aims to investigate a monopolist's dynamic product innovation problem in a price‐regulated market exhibiting network externality. We identify the sufficient conditions guaranteeing the existence of optimal steady‐state equilibrium. Our analysis mainly shows the following: (i) the product quality and network size move in opposite directions along the path to the steady‐state equilibrium; (ii) the equilibrium result of product innovation increases with the regulated price but decreases with the intensity of network externality; (iii) the social‐welfare maximizing path of product innovation can be replicated by a dynamic price regulation regime, involving a premium on quality and a premium or a penalty on network size. Numerical experiments are performed to characterize the dynamic patterns of product innovation. We find that firms with high brand power prefer adopting mild product innovation strategy while for firms with low brand power, almost constant high‐quality strategy is better.
Barriers and enablers to the implementation and sustainability of short‐stay arthroplasty programs for elective primary total hip and knee replacement: A systematic review with qualitative evidence synthesis
Authors: Berkovic Danielle , Vallance Patrick , Harris Ian A. , Naylor Justine M. , Lewis Peter L. , de Steiger Richard , Buchbinder Rachelle , Ademi Zanfina , Ackerman Ilana N. 
Published: June 2024

AbstractIntroductionWe aimed to systematically review contemporary evidence on the barriers and enablers to implementing and sustaining short‐stay arthroplasty programs for elective primary total hip and knee replacement from the perspectives of patients, health professionals, carers, healthcare administrators, funders and policymakers and to map the findings to the Theoretical Domains Framework (TDF).MethodsMedline, Cumulative Index to Nursing and Allied Health Literature, EMBASE, and the Cochrane Central Register of Controlled Trials were searched (up to 19 August 2023). Primary qualitative or mixed‐methods studies reporting on perspectives relating to the review aims that utilised a short‐stay programme were eligible for inclusion. Study quality was assessed using the qualitative critical appraisal tool from the Joanna Briggs Institute. Data were analysed inductively. The final themes were mapped to the TDF. The confidence in the findings was assessed using GRADE CERQual.ResultsFifteen studies were included. Twelve barrier themes and twelve enabler themes were identified. Three themes were graded with high confidence, 10 were graded with moderate confidence, three were graded with low confidence, and eight were graded with very low confidence. The most pertinent domains that the themes were mapped to for patients were beliefs about capabilities, reinforcement, and the environmental context and resources. Health professionals identified knowledge, environmental context and resources as important domains. Two domains were identified for carers: (1) social/professional role and identity and (2) memory, attention, and decision processes.ConclusionWe identified key barrier and enabler themes linked to the TDF that can be used to guide implementation initiatives and promote the sustainability of short‐stay arthroplasty programs.
Boundary integrated neural networks and code for acoustic radiation and scattering
Authors: Qu Wenzhen , Gu Yan , Zhao Shengdong , Wang Fajie , Lin Ji 
Published: June 2024

AbstractThis paper presents a novel approach called the boundary integrated neural networks (BINNs) for analyzing acoustic radiation and scattering. The method introduces fundamental solutions of the time‐harmonic wave equation to encode the boundary integral equations (BIEs) within the neural networks, replacing the conventional use of the governing equation in physics‐informed neural networks (PINNs). This approach offers several advantages. First, the input data for the neural networks in the BINNs only require the coordinates of “boundary” collocation points, making it highly suitable for analyzing acoustic fields in unbounded domains. Second, the loss function of the BINNs is not a composite form and has a fast convergence. Third, the BINNs achieve comparable precision to the PINNs using fewer collocation points and hidden layers/neurons. Finally, the semianalytic characteristic of the BIEs contributes to the higher precision of the BINNs. Numerical examples are presented to demonstrate the performance of the proposed method, and a MATLAB code implementation is provided as supplementary material.
Short sleep duration is associated with higher risk of central obesity in adults: A systematic review and meta‐analysis of prospective cohort studies
Authors: Kohanmoo Ali , Akhlaghi Masoumeh , Sasani Najmeh , Nouripour Fatemeh , Lombardo Caterina , Kazemi Asma 
Published: June 2024

AbstractBackground and ObjectiveThe relationship between sleep duration and obesity has been the focus of numerous investigations. This systematic review and meta‐analysis of prospective cohort studies aimed to assess the relationship between sleep duration, abdominal obesity, and body composition.MethodsPubMed, Scopus, and Web of Science were searched until February 2024. Cohort studies that assessed the relationship between sleep duration at night and central obesity measures or body composition indices in adults were included. The quality of studies was assessed using the Newcastle‐Ottawa scale. Random‐effects meta‐analysis was conducted on studies that reported risk ratio (RR) and 95% confidence intervals (CIs).ResultsEighteen studies were eligible to be included. Eleven out of the 18 studies were not included in the analysis as 10 studies did not report RR, and in one study, the definition of short and normal sleep duration was different from others. The results of the meta‐analysis indicated that short sleep duration was significantly associated with abdominal obesity (RR = 1.08; 95% CI: 1.04–1.12; I2 = 49.1%, n = 7), but long sleep duration was not (RR = 1.02; 95% CI: 0.83–1.24; I2 = 98.2%, n = 6).ConclusionsShort sleep duration was associated with a slightly higher risk of central obesity, while long sleep duration was not.
Newly formed and ruptured infectious intracranial aneurysm in few days following first intracranial aneurysm embolization concurrent with middle cerebral artery occlusion: A regrettable case in a baby child
Authors: Yang Yunying , Ma Hongtu , Hu Hui , Li Lusheng , Tang Jun 
Published: June 2024

AbstractInfectious intracranial aneurysm (IIA) and embolic cerebral infarction are well‐known devastating complications of children suffering infective endocarditis. In this report, we describe a successfully embolized IIA concurrent with bilateral middle cerebral artery (MCA) occlusion. Unfortunately, a newly formed IIA located in the contralateral MCA bifurcation ruptured at the seventh day following embolization. A 6‐month‐old female child was admitted to hospital 3 days following acute right limb mobility disorder. An interventional surgery history of congenital heart disease was confirmed. She was immediately started on antibiotic therapy and the computed tomography agiography (CTA) scan showed occlusion of the upper branch of the left MCA. Unfortunately an IIA was located in the distal artery region (DAR) of the ipsilateral anterior cerebral artery. Angiography (digital subtraction angiography) was performed and the DAR IIA was embolized by OnyX‐18 with Magic 1.2 Fr. microcatheter. On the sixth day, magnetic resonance imaging during the hospital stay showed reduced infarction area with no other special sign. Desperately, a major seizure with opisthotonos attacked the baby on the seventh day after embolization. An immediate CTA scan showed massive hematoma in the right basal ganglia and a ruptured bifurcate aneurysm of the right MCA. The parents refused positive treatment and discharged in considering the critical situation. It should be noted that IIA can be fast formed anywhere in cerebral artery and dynamic angio‐image should be performed as supervision.
The association between overuse and musculoskeletal injuries and the female athlete triad in Division I collegiate athletes
Authors: Miller Olson Emily , Sainani Kristin L. , Dyrek Paige , Bakal David , Miller Kenneth , Carlson Jennifer L. , Fredericson Michael , Tenforde Adam S. 
Published: June 2024

AbstractIntroductionAlthough the female athlete triad (Triad) has been associated with increased risk of bone‐stress injuries (BSIs), limited research among collegiate athletes has addressed the associations between the Triad and non‐BSI injuries.ObjectiveTo elucidate the relationship between Triad and both BSI and non‐BSI in female athletes.DesignRetrospective cohort study.SettingPrimary and tertiary care student athlete clinic.ParticipantsNational Collegiate Athletic Association Division I female athletes at a single institution.InterventionParticipants completed a pre‐participation questionnaire and dual‐energy x‐ray absorptiometry, which was used to generate a Triad cumulative risk assessment score (Triad score). The number of overuse musculoskeletal injuries that occurred while the athletes were still competing collegiately were identified through chart review.Main Outcome MeasureBSI and non‐BSI were treated as count variables. The association between BSI, non‐BSI, and Triad score was measured using Poisson regression to calculate rate ratios.ResultsOf 239 athletes, 43% of athletes (n = 103) sustained at least one injury. Of those, 40% (n = 95) sustained at least one non‐BSI and 10% (n = 24) sustained at least one BSI over an average follow‐up 2.5 years. After accounting for sport type (non‐lean, runner, other endurance sport, or other lean advantage sport) and baseline age, we found that every additional Triad score risk point was associated with a significant 17% increase in the rate of BSI (rate ratio [RR] 1.17, 95% confidence interval [CI] 1.03–1.33; p = .016). However, Triad score was unrelated to non‐BSI (1.00, 95% CI 0.91–1.11; p = .99). Compared with athletes in non‐lean sports (n = 108), athletes in other lean advantage sports (n = 30) had an increased rate of non‐BSI (RR: 2.09, p = .004) whereas distance runners (n = 46) had increased rates of BSI (RR: 7.65, p < .001) and non‐BSI (RR: 2.25, p < .001).ConclusionsHigher Triad score is associated with an increased risk of BSI but not non‐BSI in collegiate athletes.
Examining the impact of nano‐sized Litharge, Tenorite, and Hematite on the thermal decomposition of ammonium perchlorate‐based cross‐linked composite modified double base propellant
Authors: Fertassi Meriem Amina , Belkhiri Samir , Touidjine Sabri , Boulkadid Moulai Karim , Hamdane Akbi , Khimeche Kamel 
Published: June 2024

AbstractThis study aims to compare the catalytic effects of three nano‐metal oxides (nMOs); Litharge (α‐PbO), Tenorite (CuO), and Hematite (α‐Fe2O3) on the thermal decomposition of an ammonium perchlorate based cross‐linked composite modified double base propellant (AP‐XLCMDBP). The three nMOs are synthesized via a chemical precipitation method and then characterized using XRD, FTIR, and SEM. Their effect on the thermal decomposition of AP‐XLCMDBP is studied using thermogravimetric analysis (TGA) and differential scanning calorimeter (DSC). The results indicate that Litharge has no significant effect on the thermal decomposition of AP‐XLCMDBP. However, both Tenorite and Hematite nanocatalysts accelerate the thermolysis process and enhance the total heat released from AP‐XLCMDBP. Moreover, compared to Tenorite, Hematite nanoparticles are found to be a more efficient catalyst, where their presence in AP‐XLCMDBP leads to a significant decrease in activation energies of the first and the second decomposition stages by 13.67 kJ/mol and 17.57 kJ/mol, respectively. An increase of the total decomposition heat by 153.73 J/g is also attained in the presence of Hematite, displaying its high catalytic action on the thermal decomposition of AP‐XLCMDBP.
Eco‐friendly chemically crosslinked solid composite propellants via catalyst‐free azide‐alkyne cycloaddition
Authors: Min Byoung Sun , Kim Sung June , Shim Hong Min , Jeon Heung Bae 
Published: June 2024

AbstractWe have innovatively formulated solid propellants by employing a catalyst‐free azide‐alkyne cycloaddition approach, steering away from the conventional urethane curing system reliant on moisture‐sensitive isocyanate compounds. These conventional systems exhibits poor compatibility with the eco‐friendly ionic oxidizers. Azide polymers, including polycaprolactone ether (PCE), polycaprolactone (PCL), and polyethylene glycol (PEG) were incorporated, with their terminal hydroxyl groups strategically modified with azides. Additionally, glycidyl azide polymer (GAP), characterized by an abundance of azides in its side chains, was introduced. For polybutadiene‐based solid propellants, a departure from the norm was pursued. We employed polybutadiene (PB) terminated with electron‐deficient alkynes(propiolate), synthesized through a urethane reaction involving an unsymmetric divalent chain‐linker containing both isocyanate and propiolate functionalities with hydroxyl‐terminated polybutadiene (HTPB). This approach diverged from the common practice of modifying other polymers with azides at the terminal. To ensure the attainment of optical mechanical properties in azide‐terminated polymer‐based solid propellants, trivalent propiolate curatives were judiciously combined with divalent propiolate curatives in an appropriate blend ratio. A meticulously synthesized series of polymeric bonding agents, designed to establish chemical links between solid oxidizers and polymer binder, revealed the idenfication of exceptional bonding agents. These agents played a pivotal role in delivering outstanding mechanical properties in solid propellants based on ammonium perchlorate (AP) and nitramine‐typed oxidizers. GAP‐based solid propellants were meticulously prepared, incorporating both urethane moieties at the terminal and triazole moieties at the side chains. Trivalent azide‐terminal curatives were introduced for crosslinking PB terminated with propiolates. Generally, triazole‐curing system resulted in solid propellants exhibiting notably higher burning rates compared to those crosslinked through urethanes. In summary, this research presents a sophisticated approach to the formulation of solid propellants, emphasizing a departure from conventional systems, strategic polymer modifications, and the meticulous synthesis of bonding agents to achieve superior mechanical properties and burning rates.
Modulating hydrogen bonding through Lewis acid complexation
Authors: Mazumder Lakhya J. , Sarmah Kangkan , Guha Ankur K. 
Published: June 2024

AbstractPresent calculations reveal that complexation with a Lewis acid such as BH3 dramatically increases the strength of hydrogen bonding between H2O, H2S, HF, HCl, and NH3 dimers. The increase in strength is attributed to the increase in electrostatic component. The interaction energies were found to increase by two to three folds (more than 50% increase in interaction energies). Detailed electronic structure analyses within the realm of quantum theory of atoms in molecules and non‐covalent interaction index confirms the strengthening of hydrogen bonding due to Lewis acid complexation. Decomposition of interaction energies using symmetry adapted perturbation theory reveals that the increase in interaction energy (more than 60%) is due to the dramatic increase in electrostatic component.
Liposome‐Based Delivery of a Bis‐benzimidazole Derivative to Duplex DNA: A Spectroscopic Study
Authors: Shit Debatri , Mandal Pabitra , Das Priyabrata , Pramanik Smritimoy 
Published: June 2024

AbstractDue to the immense pharmacological significance, the interaction of small molecules with liposome and the exact knowledge of their binding location and distribution within the lipid bilayer of liposome is an active field of biophysical research. Here, we have studied the binding interaction of H33258 with DPPC liposome, a model biological membrane. From the steady‐state fluorescence spectroscopy it was revealed that H33258 bounded to DPPC liposome and the estimated binding constant value was 2.5×102 M−1. It was also revealed that the H33258 essentially partitioned within the lipid bilayer of DPPC liposome. Moreover, from steady‐state fluorescence, time‐resolved lifetime, time‐resolved anisotropy and ITC studies it was established that the probe molecules were sequestrated from the lipid bilayer and bounded to a duplex DNA structure. Our results on the binding consequences of H33258 with liposome will aid development of a simple and safe strategy to deliver drugs to the target sites using liposome, endogenously.