bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electrophysiologic correlations with clinical outcomes in CIDP
Authors: Bril Vera , Banach Marta , Dalakas Marinos C. , Deng Chunqin , Donofrio Peter , Hanna Kim , Hartung Hans‐Peter , Hughes Richard A.C. , Katzberg Hans , Latov Norman , Merkies Ingemar S.J. , Van Doorn Pieter A. ,   on behalf of the ICE Study Group* (listed in the acknowledgments)
Published: July 2010

AbstractData are lacking on correlations between changes in nerve conduction (NC) studies and treatment response in chronic inflammatory demyelinating polyneuropathy (CIDP). This report examined data from a randomized, double‐blind trial of immune globulin intravenous, 10% caprylate/chromatography purified (IGIV‐C [Gamunex]; n = 59) versus placebo (n = 58) every 3 weeks for up to 24 weeks in CIDP. Motor NC results and clinical measures were assessed at baseline and endpoint/week 24. Improvement from baseline in adjusted inflammatory neuropathy cause and treatment score correlated with improvement in proximally evoked compound muscle action potential (CMAP) amplitudes (r = −0.53; P < 0.001) of all nerves tested and with improvement in CMAP amplitude of the most severely affected motor nerve (r = −0.36; P < 0.001). Correlations were observed between improvement in averaged CMAP amplitudes and dominant‐hand grip strength (r = 0.44; P < 0.001) and Medical Research Council sum score (r = 0.38; P < 0.001). Overall, the change in electrophysiologic measures of NC in CIDP correlated with clinical response to treatment. Muscle Nerve, 2010
Alcock canal syndrome due to obturator internus muscle fibrosis
Authors: Insola Angelo , Granata Giuseppe , Padua Luca 
Published: July 2010

AbstractAlcock canal syndrome is a rare entrapment neuropathy of the pudendal nerve. We report a case of perineal neuralgia where pudendal nerve compression was due to fibrosis of the obturator internus muscle following an injury of the muscle. After being misdiagnosed for 2 years, the patient was diagnosed only after a combined neurophysiologic and magnetic resonance imaging (MRI) investigation. This case underlines the importance of performing focused neurophysiologic and neuroimaging studies in patients with neuropathic perineal pain in order to reach a correct diagnosis. Muscle Nerve, 2010
Inhibitory activity of α‐tocoferol on apoptosis in the rat bladder wall subjected to androgen deprivation
Authors: Ludwig Luana , Seraphim Deborah , Lorenzetti Fábio , Bertolla Ricardo Pimenta , Ortiz Valdemar , Dambros Miriam 
Published: July 2010

AbstractAlpha‐tocopherol (2,5,7,8‐tetramethyl‐2‐(4,8,12‐trimethyltridecyl)‐chromon‐8‐ol) is used in many previous urological studies. Thus to add to this knowledge in this study we studied the potential inhibitory activity on oxidative stress and process apoptosis on bladder wall in male rats subjected to androgen deprivation. A causal relationship between lower testosterone levels and apoptosis, as a component of castration‐induced muscle atrophy, has been shown. Male Wistar rats (250–300 g) were used in this experiment, divided into four groups: control (sham operation; n = 10); castration (n = 10); castration, with alpha‐tocopherol supplementation over preceding four weeks (n = 10); and castration, with alpha‐tocopherol supplementation over preceding four weeks and subsequent eight weeks (n = 10). Activated caspase‐3 was detected using a previously described technique, with analysis using stereological methodology. Nonparametric methods were used to test statistical significance, taking a significance level of P < 0.005. This study was approved by the ethics committee of the university where the project was developed. The serum testosterone concentrations before castration were less than 20 pg/ml. Analysis of 8‐isoprostane showed statistical significance (P < 0.0003). The volumetric density of caspase‐3 showed significant differences between the groups. There was no statistical significance regarding caspase‐3 between sham and alpha‐tocopherol plus castration or between the groups that received alpha‐tocopherol supplementation. The observations showed that there was greater apoptosis in the group with castration alone than in the groups with alpha‐tocopherol supplementation. This finding, together with the induced androgen deprivation and higher 8‐isoprostane levels, corroborates the hypothesis that alpha‐tocopherol supplementation has an important protective effect under conditions of oxidative stress, thereby avoiding the apoptotic process, especially regarding aging. Neurourol. Urodyn. 30:194–198, 2011. © 2010 Wiley‐Liss, Inc.
The safety and efficacy of the “inside‐out” trans‐obturator TVT in elderly versus younger stress‐incontinent women: A prospective study of 353 consecutive patients
Authors: Groutz Asnat , Cohen Aviad , Gold Ronen , Pauzner David , Lessing Joseph B. , Gordon David 
Published: July 2010

AbstractObjectivesTo analyze the safety and efficacy of the trans‐obturator tension‐free vaginal tape (TVT‐O) in elderly versus younger stress‐incontinent women.MethodsNinety‐seven consecutive elderly, aged 70 and older, and 256 younger women (mean age 75 and 55 years, respectively) who underwent TVT‐O for urodynamically confirmed stress urinary incontinence (SUI) were prospectively enrolled. Concomitant pelvic organ prolapse (POP) repair was performed in 90% of the elderly and 70% of the younger women. The surgical procedures, as well as all pre‐ and postoperative clinical and urodynamic evaluation, were performed in one university‐affiliated medical center. Main outcome measures were operative complications, early and late postoperative morbidity, postoperative urodynamically confirmed SUI (symptomatic, or asymptomatic), persistent, or de novo overactive bladder (OAB) and bladder outlet obstruction (BOO).ResultsMean follow‐up of the patients was 30 ± 17 months (range 3–58 months). Early and late postoperative morbidity was similar in both groups, except for significantly more cases of postoperative recurrent UTI's among elderly women (13.7% vs. 6.2%). The incidence of persistent urodynamically confirmed overt SUI was similar in both age groups (5%). However, asymptomatic urodynamic SUI was significantly more common among elderly patients (19% vs. 3.7%, P < 0.05). The incidence of persistent OAB was similar in elderly and younger patients (68% and 62%, respectively), while de novo OAB was significantly more common in elderly patients (11.9% vs. 4.7%, P < 0.05).ConclusionsTVT‐O is safe and efficient for both elderly and younger stress‐incontinent women. However, elderly patients are in increased risk for postoperative recurrent UTI's as well as de novo OAB. Neurourol. Urodynam. 30:380–383, 2011. © 2010 Wiley‐Liss, Inc.
Note on optimal ordering policy with different lead times and convex ordering costs
Authors: Xu Ningxiong 
Published: July 2010

AbstractThis note generalizes Fukuda's two‐alternate‐lead‐times model (1964) with linear ordering costs to the case where the ordering costs are convex. We use lattice programming to show the qualitative properties of an optimal ordering policy if the ordering costs are convex and to further characterize the structure of an optimal ordering policy if the ordering costs are convex and piecewise linear. Copyright © 2010 John Wiley & Sons, Ltd.
You can win by losing: p53 mutations in rhabdomyosarcomas
Authors: Post Sean M , Lozano Guillermina 
Published: July 2010

AbstractRhabdomyosarcomas are soft tissue sarcomas of mesenchymal origin. Unlike rhabdomyosarcomas observed in paediatric patients which typically respond well to chemotherapeutic treatment, adults generally present with pleomorphic rhabdomyosarcomas that are typically associated with poor prognosis. Therefore, understanding the molecular biology that gives rise to pleomorphic rhabdomyosarcomas is critical. In this issue of The Journal of Pathology, Doyle and colleagues have generated elegant tissue‐specific Cre/loxP‐dependent mouse models that mimic pleomorphic rhabdomyosarcoma development in humans. In this report, the authors employed KRasG12V‐expressing mouse models that concomitantly either express mutant p53 (p53R172H) or have deleted the p53 gene. Mice that express mutant p53 have decreased survival with development of aggressive metastases as compared to mice that have simply lost wild‐type p53. The data presented herein provide the first in vivo evidence that in rhabdomyosarcomas, expression of mutant p53 results in a more aggressive p53R172H‐dependent gain‐of‐function phenotype. Copyright © 2010 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.Invited Commentary for Doyle B et al. p53 mutation and loss have different effects on tumourigenesis in a novel mouse model of pleomorphic rhabdomyosarcoma. Journal of Pathology, 2010; 222: 129–137.
Zytostatikaherstellung in der Apotheke. Trends und Perspektiven
Authors: Krämer Irene 
Published: July 2010

AbstractNach zaghaften Anfängen der zentralen Zytostatikaherstellung in Krankenhausapotheken vor mehr als 25 Jahren findet heute in Deutschland die Herstellung patientenindividueller applikationsfertiger Zytostatikazubereitungen selbstverständlich in den Apotheken statt. Dies gilt sowohl für die Anwendung der Produkte im Krankenhaus als auch für die Behandlung in onkologischen Praxen.
Magistrale Rezepturen aus der Sicht der Dermatologie. Obsolet oder Up‐to‐date?
Authors: Staubach Petra 
Published: July 2010

AbstractDermatologische Magistralrezepturen sind sinnvoll und haben ihren Stellenwert nicht nur in der Dermatologie. Die Leitlinien der dermatologischen Gesellschaft sollten die Magistralrezepturen forcieren und unterstützen (Abb. 5). Durch die interdisziplinäre Zusammenarbeit zwischen Dermatologen und Pharmazeuten können therapeutische Lücken schnell geschlossen werden. So wurden in den letzten Jahren Magistralrezepturen für Schleimhauterkrankungen (Cortison‐ und Tretinoinhaltige Haftpasten), Antiseptika, sowie Prednisolon‐Saft für die Notfallversorgung als Resultat einer fruchtbaren interdisziplinären Zusammenarbeit entwickelt und veröffentlicht. Eine verbesserte Compliance sowie sozioökonomische Aspekte unterstreichen den Wert von Magistralrezepturen. Die Verwendung der standardisierten Rezepturen des NRF sollte in der dermatologischen Praxis Vorrang haben und wird durch die Verfügbarkeit des “Ärzte NRF” im Kitteltaschenformat gezielt unterstützt.
Thermoplastic vibration welding: Review of process phenomenology and processing–structure–property interrelationships
Authors: Patham Bhaskar , Foss Peter H. 
Published: July 2010

AbstractVibration welding offers a robust method for physically joining thermoplastics to fabricate complex hollow assemblies from simpler injection‐molded articles without using an external heat source, adhesives, or mechanical fasteners. Vibration welding involves a complex interplay of several phenomena—solid (Coulomb) friction, melting, high strain‐rate, pressure‐driven, strong (high‐strain) melt flows, solidification, and microstructure development—which ultimately govern the strength and integrity of the weld. Defects in the weld region may lead to catastrophic failure of the welded assembly. In this article, the current understanding of the processing–structure–property relationships in the context of vibration welding of thermoplastics and polymer‐matrix composites is reviewed. Experimental as well as analytical methods of investigation of the vibration welding process phenomenology are presented. The interrelationships between the microstructure in the weld region and the resulting weld strength and fatigue behavior are then discussed in the light of this phenomenological information for neat polymers, filled polymers, polymer blends, and foams. This review is also aimed at identifying the areas requiring further investigation with regard to understanding vibration welding phenomenology and weld structure–property relationships. POLYM. ENG. SCI., 2011. © 2010 Society of Plastics Engineers
Experimental and modeling studies on the solubility of sub‐ and supercritical carbon dioxide (scCO2) in potato starch and derivatives
Authors: Muljana Henky , Picchioni Francesco , Heeres Hero J. , Janssen Leon P.B.M. 
Published: July 2010

AbstractThe solubility of CO2 in native potato starch (NPS) and potato starch acetate (SA) at two different temperatures (50°C and 120°C) and various pressures (up to 25 MPa) was determined using a magnetic suspension balance. Within the experimental window, a maximum solubility of 31 mg CO2/gsample for NPS and 79.4 mg CO2/gsample for SA was obtained. The CO2 sorption behavior is highly depending on the temperature and pressure. The solubility data were modeled with the Sanchez Lacombe equation of state (S‐L EOS). The swelling (Sw) values, as predicted using the S‐L EOS, were relatively small and a maximum value of 6.1% was obtained for SA at 25 MPa and 120°C. POLYM. ENG. SCI., 2011. © 2010 Society of Plastics Engineers
Simulation of screw pumping characteristics for intermeshing counter‐rotating twin screw extruders
Authors: Jiang Qibo , Yang Jinhai , White James L. 
Published: July 2010

AbstractIntermeshing counter‐rotating twin screw extruders play an important role in polymer processing, especially for the extrusion of profiles and pipe, largely from polyvinyl chloride. There has been little effort on flow modeling of these machines and most of this has involved representing the machine as a “leaky” positive displacement pump and estimating leakages. In recent years, M.H. Hong and the authors have developed more general methods of simulation of flow in this machine and both applied and experimentally verified it for a few designs. Here we extend these efforts to a broader range of screw designs, especially with deeper screw channels where transverse shearing induced by the flights is important. Calculations are done for isothermal power law fluids. The results are compared with experiment. POLYM. ENG. SCI., 2011. © 2010 Society of Plastics Engineers
Proteomic analysis of synaptosomal protein expression reveals that cerebral ischemia alters lysosomal Psap processing
Authors: Costain Willard J. , Haqqani Arsalan S. , Rasquinha Ingrid , Giguere Marie‐Soleil , Slinn Jacqueline , Zurakowski Bogdan , Stanimirovic Danica B. 
Published: July 2010

AbstractCerebral ischemia (CI) induces dramatic changes in synaptic structure and function that precedes delayed post‐ischemic neuronal death. Here, a proteomic analysis was used to identify the effects of focal CI on synaptosomal protein levels. Contralateral and ipsilateral synaptosomes, prepared from adult mice subjected to 60 min middle cerebral artery occlusion, were isolated following 3, 6 and 20 h of reperfusion. Synaptosomal protein samples (n=3) were labeled using the cleavable ICAT™ system prior to analysis with nanoLC‐MS/MS. Each sample was analyzed by LC‐MS to identify differential expressions using InDEPT software and differentially expressed peptides were identified by targeted LC‐MS/MS. A total of 62 differentially expressed proteins were identified and Gene Ontology classification (cellular component) indicated that the majority of the proteins were located in the mitochondria and other components consistent with synaptic localization. The observed alterations in synaptic protein levels poorly correlated with gene expression, indicating the involvement of post‐transcriptional regulatory mechanisms in determining post‐ischemic synaptic protein content. Additionally, immunohistochemistry analysis of prosaposin (Psap) and saposin C (SapC) indicates that CI disrupts Psap processing and glycosphingolipid metabolism. These results demonstrate that the synapse is adversely affected by CI and may play a role in mediating post‐ischemic neuronal viability.
A proteomics approach to study synergistic and antagonistic interactions of the fungal–bacterial consortiumFusarium oxysporumwild‐type MSA 35
Authors: Moretti Marino , Grunau Alexander , Minerdi Daniela , Gehrig Peter , Roschitzki Bernd , Eberl Leo , Garibaldi Angelo , Gullino Maria Lodovica , Riedel Kathrin 
Published: July 2010

AbstractFusarium oxysporumis an important plant pathogen that causes severe damage of many economically important crop species. Various microorganisms have been shown to inhibit this soil‐borne plant pathogen, including non‐pathogenicF. oxysporumstrains. In this study,F. oxysporumwild‐type (WT) MSA 35, a biocontrol multispecies consortium that consists of a fungus and numerous rhizobacteria mainly belonging to γ‐proteobacteria, was analyzed by two complementary metaproteomic approaches (2‐DE combined with MALDI‐Tof/Tof MS and 1‐D PAGE combined with LC‐ESI‐MS/MS) to identify fungal or bacterial factors potentially involved in antagonistic or synergistic interactions between the consortium members. Moreover, the proteome profiles ofF. oxysporumWT MSA 35 and its cured counter‐part CU MSA 35 (WT treated with antibiotics) were compared with unravel the bacterial impact on consortium functioning. Our study presents the first proteome mapping of an antagonisticF. oxysporumstrain and proposes candidate proteins that might play an important role for the biocontrol activity and the close interrelationship between the fungus and its bacterial partners.
Protein Information and Knowledge Extractor: Discovering biological information from proteomics data
Authors: Medina‐Aunon J. Alberto , Paradela Alberto , Macht Marcus , Thiele Herbert , Corthals Garry , Albar Juan Pablo 
Published: July 2010

AbstractOne of the main goals in proteomics is to solve biological and molecular questions regarding a set of identified proteins. In order to achieve this goal, one has to extract and collect the existing biological data from public repositories for every protein and afterward, analyze and organize the collected data. Due to the complexity of this task and the huge amount of data available, it is not possible to gather this information by hand, making it necessary to find automatic methods of data collection. Within a proteomic context, we have developed Protein Information and Knowledge Extractor (PIKE) which solves this problem by automatically accessing several public information systems and databases across the Internet. PIKE bioinformatics tool starts with a set of identified proteins, listed as the most common protein databases accession codes, and retrieves all relevant and updated information from the most relevant databases. Once the search is complete, PIKE summarizes the information for every single protein using several file formats that share and exchange the information with other software tools. It is our opinion that PIKE represents a great step forward for information procurement and drastically reduces manual database validation for large proteomic studies. It is available at http://proteo.cnb.csic.es/pike.
Investigation of the substituent specific cross‐interaction effects on 13C NMR of the CN bridging group in substituted benzylidene anilines
Authors: Cao Chenzhong , Lu Bingtao , Chen Guanfan 
Published: July 2010

AbstractThe substituent effect on 13C NMR of the CN in benzylidene anilines XPhCHNPhY was investigated, in which the substituents X and Y are in p‐position or in m‐position of the two aromatic rings. The substituent effects including the inductive effects of X and Y, the conjugative effects of X and Y, and the substituent specific cross‐interaction effect were put into one model to quantify the 13C NMR chemical shift δC(CN) of the CN in XPhCHNPhY. A penta‐parameter correlation equation with correlation coefficient 0.9975 and standard error 0.17 ppm was obtained for 80 samples of compounds. The result shows that the substituents X and Y have an opposite effect on the δC(CN). The electron‐withdrawing effects of X decrease the δC(CN); while the electron‐donating effects of X increase the δC(CN). In contrast, the electron‐withdrawing effects of Y increase the δC(CN); while the electron‐donating effects of Y decrease the δC(CN). A new substituent specific cross‐interaction effect parameter Δσ2 was proposed, which indicates that the most substituent specific cross‐interaction effect exists in the pair of max electron‐withdrawing group (EWG) and max electron‐donating group (EDG) or the pair of max EDG and max EWG. Further to verify the obtained correlation equation, 15 samples of model compounds were prepared and their δC(CN) was measured in this work. The predicted δC(CN) values with the obtained equation are in good agreement with the measured ones for these prepared compounds, which confirmed the reliability of the obtained equation. Copyright © 2010 John Wiley & Sons, Ltd.
Solvent effects on tautomerics equilibria in β‐ketonitriles: NMR and theoretical studies
Authors: Ruiz Danila L. , Albesa Alberto G. , Ponzinibbio Agustín , Allegretti Patricia E. , Schiavoni María M. 
Published: July 2010

AbstractSolvent effects on tautomeric equilibria in several β‐ketonitriles has been investigated using nuclear magnetic resonance (NMR) spectroscopy and theoretical methods. The experimental chemical shifts were compared with theoretical values obtained by using gauge‐including atomic orbital (GIAO) calculations, implemented at Density Functional Theory (DFT) level with hybrid functionals, B3LYP calculations. The solvent effect on the calculated structures has been taken into account through the polarized continuum model (PCM) for chloroform, acetone and dimethyl sulfoxide (DMSO). Also, some structural parameters were calculated in gas phase and in three different solvents. Copyright © 2010 John Wiley & Sons, Ltd.
Anti‐complement activity of isolated compounds from the roots of Clerodendrum bungei Steud.
Authors: Kim Soo‐Ki , Cho Sang‐Buem , Moon Hyung‐In 
Published: July 2010

AbstractTo determine the anti‐complement activity of natural diterpenes, chromatographic separation of the acetone‐soluble fraction from the roots of Clerodendrum bungei (Verbenaceae) led to the isolation of five diterpenoids. An acetone‐soluble extract of the roots of C. bungei exhibited significant anti‐complement activity on the classical pathway complement system, which was expressed as total hemolytic activity. Five compounds isolated from the roots of C. bungei, namely 12‐O‐β‐d‐glucopyranosyl‐3,11,16‐trihydroxyabieta‐8,11,13‐triene (1), 3,12‐O‐β‐d‐diglucopyranosyl‐11,16‐dihydroxyabieta‐8,11,13‐triene (2), ajugaside A (3), uncinatone (4) and 19‐hydroxyteuvincenone F (5). Compounds 1, 2, 3, 4 and 5 showed inhibitory activity against complement system with 50% inhibitory concentrations (IC50) values of 24 µm, 138 µm, 116 µm, 87 µm and 232 µm. Among the compounds tested, 1 showed the most potent anti‐complement activity (IC50, 24 µm). Copyright © 2010 John Wiley & Sons, Ltd.
Attitude stabilization of rigid spacecraft with finite‐time convergence
Authors: Zhu Zheng , Xia Yuanqing , Fu Mengyin 
Published: July 2010

AbstractThe problem of attitude control for a spacecraft model which is nonlinear in dynamics with inertia uncertainty and external disturbance is investigated in this paper. Two sliding mode controllers are proposed to force the state variables of the closed‐loop system to converge to the origin in finite time. Specially, the second control design consists of the estimation of the uncertainty and disturbance by adaptive method and thus it achieves the decrease of undesired chattering effectively. Also, simulation results are presented to illustrate the effectiveness of the control strategies. Copyright © 2010 John Wiley & Sons, Ltd.