bluuebunny/crossref_metadata_2025_split huggingface dataset:
Social support, life stress, and anxiety as predictors of pregnancy complications in low‐income women
Authors: Zachariah Rachel 
Published: May 2009

AbstractProspective repeated measures were used to examine attachment, social support, life stress, anxiety, and psychological wellbeing among low‐income women in early and late pregnancy and the relationships of these variables to prenatal, intrapartum, and neonatal complications. One hundred and eleven medically healthy, low‐income, Medicaid‐eligible women ages 18–35 years, between 14 and 22 weeks of pregnancy were recruited from prenatal clinics. Self‐report questionnaires and hospital records were used to collect data. Discriminant analysis was performed. The most important discriminating factors for prenatal complications were state anxiety and total functional social support. The factors for neonatal complications were negative life events and the interaction of emotional support with negative life events. © 2009 Wiley Periodicals, Inc. Res Nurs Health 32: 391–404, 2009
Familial retinoblastoma in developing countries
Authors: Chantada Guillermo L. , Dunkel Ira J. , Qaddoumi Ibrahim , Antoneli Celia B.G. , Totah Alegria , Canturk Serife , Nawaiseh Ibrahim , Fandiño Adriana , Pífano Imelda , Peksayar Gonul , Ribeiro Karina Braga , Abramson David H. 
Published: May 2009

AbstractBackgroundAlthough screening for familial retinoblastoma has been shown to be beneficial we suspected that such screening programs may be less than optimal in developing countries (DC).MethodsRetrospective cohort study comparing patients with familial retinoblastoma from five centers in DC (Argentina, Brazil, Turkey, Jordan, and Venezuela) versus a reference center in the USA.ResultsNinety‐two (32 from the USA and 60 from DC) patients were included. Forty‐one (44.6%) patients avoided enucleation, 42 (45.7%) had 1 eye removed, and 9 (9.8%) underwent bilateral enucleation. Eleven (11.9%) had major pathology risk factors at enucleation. There were no cases of metastatic disease at diagnosis. Detection via screening was significantly less common in DC than in the USA (23.3% vs. 71.8%, P < 0.0001). Patients in DC were diagnosed at a significantly later age and with more advanced intraocular disease that led to increased risk of bilateral enucleation. Patients detected by screening in DC were significantly younger at diagnosis, had less advanced intraocular disease, better ocular preservation rates and survival results than those whose retinoblastoma was not detected via early screening. Five‐year pEFS was 0.92 for the patients treated in the USA and 0.81 for the patients in DC (P = 0.42). Seven events occurred (extraocular relapse four in patients from DC and second malignancies in three).ConclusionsPatients with familial retinoblastoma are less likely to be diagnosed by screening in DC and had higher morbidity and mortality caused by recurrent extraocular retinoblastoma. Pediatr Blood Cancer 2009;53:338–342. © 2009 Wiley‐Liss, Inc.
Secondary supratentorial primitive neuroectodermal tumor following treatment of childhood osteosarcoma
Authors: Fitzhugh Courtney D. , Wise Barbara , Baird Kristin , Tsokos Maria , Helman Lee , Mackall Crystal , Savage Sharon A. , Warren Katherine E. 
Published: May 2009

AbstractA 16‐year‐old Caucasian male was diagnosed with a primitive neuroectodermal tumor (PNET) 5 years following the diagnosis of nonmetastatic osteosarcoma of the left proximal humerus. The patient was initially treated with standard chemotherapy and limb salvage resection for osteosarcoma. Nine months after the completion of therapy, he developed lung metastases for which he underwent surgical resection and received additional chemotherapy. Almost 5 years after the osteosarcoma diagnosis, the patient was diagnosed with a supratentorial PNET, which represents the first known case reported in a patient with osteosarcoma. Pediatr Blood Cancer 2009;53:496–498. Published 2009 Wiley‐Liss, Inc.
Risk factors for visual impairment registration due to diabetic retinopathy in Leeds, 2002–2005
Authors: Hayat H , Bodansky HJ , Nayak D , Ashiq A , McKibbin M , Goyder E 
Published: May 2009

AbstractWe undertook a retrospective study of case notes of those patients registered blind or partially sighted due to diabetic retinopathy in the Leeds metropolitan area in the years 2002 and 2005.Both the incidence of visual impairment due to diabetic retinopathy and the relative contribution to total registrations are similar to those observed in other local and national studies. The main risk factors for registered visual impairment were poor glycaemic control prior to ophthalmic review, no prior retinopathy screening, late presentation with symptomatic visual loss, non‐compliance with planned review and laser treatment failure. Most of these risk factors are avoidable. Nearly two‐thirds of patients diagnosed with diabetes mellitus were being screened for diabetic retinopathy. These figures would suggest that the National Service Framework for Diabetes' proposed coverage of 80% by 2006 and 100% by the end of 2007 is achievable. The duration of diagnosed diabetes mellitus at the time of registration was an average of 16 years in this study. This reflects the slow development of sight‐threatening retinopathy and visual loss observed previously. Conventional therapy for diabetic retinopathy with laser photocoagulation reduces the risk of visual loss more effectively than it improves visual function. Despite the increased risk of early worsening of retinopathy seen with intensive glycaemic control in the Diabetes Control and Complications Trial and the UK Prospective Diabetes Study, improved control closer to the time of diagnosis of diabetes mellitus would have helped to provide a sustained reduction in the risk of retinopathy developing or progressing. Both laser treatment failure and non‐attendance may limit the benefits of improved screening coverage. Copyright © 2009 John Wiley & Sons.
Guidelines on the current best practice for the management of type 1 diabetes, sport and exercise
Authors: Perry E , Gallen IW 
Published: May 2009

AbstractWith the overwhelming health benefits of regular exercise and the increasing recognition that individuals with type 1 diabetes can compete in all types of sport and exercise at all levels, there is increasing demand for evidence‐based guidance on the management of type 1 diabetes, sport and exercise.Although there have been a number of recent studies advancing our understanding of possible management strategies, there is currently little in the way of practical guidance available for health care professionals.This article aims to empower health care professionals working in clinical practice within the field of type 1 diabetes, sport and exercise. The first section of the article summarises the physiological challenges to glucose homeostasis anticipated from different types of exercise in an individual with type 1 diabetes. The second section considers the current evidence base and recognised strategies available to overcome these physiological challenges.Although this article does not cover ‘every insulin regimen’ or ‘every eventuality’ it provides health care professionals with the knowledge to predict the impact of different sports and exercises on glucose homeostasis in an individual with type 1 diabetes, and an awareness of the potential strategies available to allow safe and successful participation in sport and exercise without compromise to glycaemic control. Copyright © 2009 John Wiley & Sons.
Treatment refusal and abandonment in childhood acute lymphoblastic leukemia in Indonesia: an analysis of causes and consequences
Authors: Sitaresmi Mei Neni , Mostert Saskia , Schook Romane Milia , Sutaryo  , Veerman Anjo J. P. 
Published: May 2009

AbstractBackground: Treatment refusal and abandonment are common causes of treatment failure in childhood acute lymphoblastic leukemia (ALL) in many developing countries. In most studies reasons for abandonment were based on the opinion of health‐care providers (HCP), very few studies have focused on the parental point‐of‐view. Aims of the study were to analyze the parents' reasons of abandonment and to ascertain the fate of children who abandoned treatment in a pediatric oncology centre in Yogyakarta, Indonesia.Methods: We conducted home‐visits to interview families of ALL patients, diagnosed between January 2004 and August 2007, who refused or abandoned treatment.Results: From January 2004 to August 2007, 159 patients were diagnosed with ALL of which 40 children (25%) refused or abandoned therapy. Thirty‐seven (93%) of these children were home‐visited. Reasons for abandonment were complex. Most parents mentioned several reasons. Financial and transportation difficulties were not the only, or even the main reasons, for abandonment. Belief of ALL incurability, experience of severe side effects and dissatisfaction with HCP were also important considerations. Most patients (64%) abandoned treatment during the diagnostic‐evaluation or remission‐induction phase. Of the 37 patients who refused or abandoned treatment, 26 (70%) children died, and 11 (30%) children were still alive, 2 of them more than 2 years after abandonment.Conclusions: Reducing treatment abandonment of childhood ALL in developing countries requires not only financial and transportation support, but also parental education, counseling and psychosocial support during therapy, improvement of quality‐of‐care and adequate management of side effects. Copyright © 2009 John Wiley & Sons, Ltd.
Gorham–Stout Syndrome with chylothorax: Successful remission by interferon alpha‐2b
Authors: Kose Mehmet , Pekcan Sevgi , Dogru Deniz , Akyuz Canan , Ozcelik Ugur , Ozsurekci Yasemin , Gulhan Bora , Demircin Metin , Kiper Nural 
Published: May 2009

AbstractGorham–Stout syndrome is a rare disease and most often recognized in children and young adults. Chylothorax is a serious complication of Gorham–Stout syndrome. The treatment of either Gorham–Stout syndrome or chylothorax is still a dilemma. We described a 9‐year‐old girl with Gorham–Stout syndrome and chylothorax who was admitted to our hospital because of dyspnea, orthopnea, and bone pain, and treated with interferon alpha‐2b. Pediatr Pulmonol. 2009; 44:613–615. © 2009 Wiley‐Liss, Inc.
Fungal pleural effusion secondary to a rare cause of pancreatic pseudocyst
Authors: Gupta Atul , Marrs Tom , Urquhart Donald , Clarke Simon , Rosenthal Mark , Bush Andrew 
Published: May 2009

AbstractWe report a case of fungal pleural effusion secondary to presumed valproate induced pancreatitis with pseudocyst and stricture formation. A child with dyskinetic cerebral palsy who had been on sodium valproate for several years was transferred for drainage of a left sided pleural effusion. Pleural fluid culture consistently grew Candida glabrata although the patient was treated with broad‐spectrum antibiotic and antifungal therapy. Clinical deterioration ensued with abdominal discomfort, feed intolerance, and re‐accumulation of the effusion. Investigations revealed a large pancreatic pseudocyst compressing the stomach and impairing pancreatic function. Subsequent therapeutic evacuation of pancreatic fluid demonstrated C. glabrata. This case underscores that pleural disease may be secondary to abdominal pathology, and always to consider rare side‐effects of medication in the face of a puzzling clinical picture. Pediatr Pulmonol. 2009; 44:616–618. © 2009 Wiley‐Liss, Inc.
Mucoid Inquilinus limosus in a young adult with cystic fibrosis
Authors: Hayes Don , Murphy Brian S. , Kuhn Robert J. , Anstead Michael I. , Feola David J. 
Published: May 2009

AbstractInquilinus limosus is a α‐proteobacterium that has been recently isolate in the airways of cystic fibrosis (CF) patients. We report the isolation of a mucoid strain of I. limosus from the sputum of a 20‐year‐old male patient with CF over 1 year that was associated with the clinical, spirometric, and radiographic decline in a previously healthy patient. Pediatr Pulmonol. 2009; 44:619–621. © 2009 Wiley‐Liss, Inc.
Inhibition of de novo purine synthesis in human prostate cells results in ATP depletion, AMPK activation and induces senescence
Authors: Obajimi Oluwakemi , Keen Judith Clancy , Melera Peter W. 
Published: May 2009

AbstractBACKGROUND4‐[2‐(2‐Amino‐4‐oxo‐4,6,7,8‐tetrahydro‐3H‐pyrimidino[5,4,6][1,4]thiazin‐6‐yl)‐(S)‐ethyl]‐2,5‐thienoylamino‐l‐glutamic acid (AG2034), is a classical antifolate shown to be an excellent inhibitor of glycinamide ribonucleotide formyltransferase (GARFT), ultimately inhibiting de novo purine synthesis. We examined some metabolic effects of this drug in prostate cancer cells, LNCaP, versus non‐tumorigenic prostatic epithelial cells, RWPE‐1.METHODS AND RESULTSCells were cultured in medium containing 10 nM 5‐methyl‐tetrahydrofolate supplemented with/without 1.7 µM hypoxanthine/1.5 µM thymidine. Cytotoxicity of AG2034 was determined by clonogenic assays. Total ATP was quantified by reverse‐phase HPLC and [14C]‐glycine incorporation and [3H]‐hypoxanthine conversion into ATP by liquid scintillation counting. Protein expression levels were determined by Western blotting, cell cycle analysis by propidium iodide staining and cell‐senescence by β‐galactosidase staining. AG2034 inhibited LNCaP cell proliferation causing death in the absence of hypoxanthine and cytostasis in its presence. However, RWPE‐1 cells were resistant to AG2034 when hypoxanthine was present. AG2034 elevates AMP/ATP ratios but is unable to activate AMPK in RWPE‐1 when hypoxanthine is present. Drug exposure increased expression levels of p53, p21, p27, and p16 in both cell lines and increased senescence‐associated‐β‐gal staining in LNCaP with/without hypoxanthine, but primarily in its absence in RWPE‐1.CONCLUSIONSLNCaP cells primarily depend upon de novo while RWPE‐1 cells largely favor salvage synthesis for maintenance of their ATP pools. With AG2034 treatment, ATP synthesis via hypoxanthine salvage is insufficient to support growth of LNCaP but enough to restore ATP levels and support RWPE‐1 growth. The anti‐proliferative effect of AG2034 involves increasing phosphorylation of AMPK. These results indicate that AG2034 activates p53 and AMPK mediating the induction of signaling pathways leading to senescence. Prostate 69:1206–1221, 2009. © 2009 Wiley‐Liss, Inc.
Tranilast inhibits hormone refractory prostate cancer cell proliferation and suppresses transforming growth factor β1‐associated osteoblastic changes
Authors: Izumi Kouji , Mizokami Atsushi , Li You Qiang , Narimoto Kazutaka , Sugimoto Kazuhiro , Kadono Yoshifumi , Kitagawa Yasuhide , Konaka Hiroyuki , Koh Eitetsu , Keller Evan T. , Namiki Mikio 
Published: May 2009

AbstractBACKGROUNDTranilast is a therapeutic agent used in treatment of allergic diseases, although it has been reported to show anti‐tumor effects on some cancer cells. To elucidate the effects of tranilast on prostate cancer, we investigated the mechanisms of its anti‐tumor effect on prostate cancer.METHODSThe anti‐tumor effects and related mechanisms of tranilast were investigated both in vitro on prostate cancer cell lines and bone‐derived stromal cells, and in vivo on severe combined immunodeficient (SCID) mice. We verified its clinical effect in patients with advanced hormone refractory prostate cancer (HRPC).RESULTSTranilast inhibited the proliferation of LNCaP, LNCaP‐SF, and PC‐3 cells in a dose‐dependent manner and growth of the tumor formed by inoculation of LNCaP‐SF in the dorsal subcutis and in the tibia of castrated SCID mice. Flow cytometry and TUNEL assay revealed induction of cell cycle arrest and apoptosis by tranilast. Tranilast increased expression of proteins involved in induction of cell cycle arrest and apoptosis. Coculture with bone‐derived stromal cells induced proliferation of LNCaP‐SF cells. Tranilast also suppressed secretion of transforming growth factor β1 (TGF‐β1) from bone‐derived stromal cells, which induced their differentiation. Moreover, tranilast inhibited TGF‐β1‐mediated differentiation of bone‐derived stromal cells and LNCaP‐SF cell migration induced by osteopontin. In the clinical investigation, PSA progression was inhibited in 4 of 16 patients with advanced HRPC.CONCLUSIONSThese observations suggest that tranilast may be a useful therapeutic agent for treatment of HRPC via the direct inhibitory effect on cancer cells and suppression of TGF‐β1‐associated osteoblastic changes in bone metastasis. Prostate 69:1222–1234, 2009. © 2009 Wiley‐Liss, Inc.
Structural study of Carcinus maenas hemocyanin by native ESI‐MS: Interaction with L‐lactate and divalent cations
Authors: Bruneaux Matthieu , Terrier Peran , Leize Emmanuelle , Mary Jean , Lallier François H. , Zal Franck 
Published: May 2009

AbstractThe interaction of L‐lactate and divalent cations with Carcinus maenas hemocyanin has been probed by electrospray ionization mass spectrometry under conditions preserving noncovalent interactions (native ESI‐MS). C. maenas native hemocyanin in the hemolymph occurs mainly as dodecamers and to a lesser extent as hexamers. A progressive acidification with formic acid after alkaline dissociation resulted in the preferential recruitment of the two lightest subunits into light dodecamers, a molecular complex absent from native hemolymph, in addition to regular dodecamers and hexamers. Addition of L‐lactic acid also induced the recruitment of these subunits, even at alkaline pH. A dodecamer‐specific subunit is needed to enable aggregation over the hexameric state. Experiments with EDTA suggested the existence of different binding sites and association constants for divalent cations within hexameric structures and at the interface between two hexamers. L‐lactic acid specific interaction with the lightest subunits was not inhibited by removal of the divalent cations. Proteins 2009. © 2009 Wiley‐Liss, Inc.
Comparative modeling of human NSF reveals a possible binding mode of GABARAP and GATE‐16
Authors: Thielmann Yvonne , Weiergräber Oliver H. , Ma Peixiang , Schwarten Melanie , Mohrlüder Jeannine , Willbold Dieter 
Published: May 2009

AbstractVesicular trafficking is an important homeostatic process in eukaryotic cells which critically relies on membrane fusion. One of the essential components of the universal membrane fusion machinery is NSF (N‐ethylmaleimide‐sensitive factor), a large hexameric ATPase involved in disassembly of SNARE (soluble NSF attachment protein receptor) complexes. To improve our understanding of this sophisticated molecular machine, we have modeled the structure of the NSF hexamer in two alternative assemblies. Our data suggest a mechanistic concept of the operating mode of NSF which helps to explain the functional impact of post‐translational modifications and mutations reported previously. Furthermore, we propose a binding site for the ubiquitin‐like proteins GABARAP and GATE‐16, which is supported by experimental evidence, yielding a complex with favorable surface complementarity. Proteins 2009. © 2009 Wiley‐Liss, Inc.
Antifeedant and sublethal effects of imidacloprid on Asian citrus psyllid, Diaphorina citri
Authors: Boina Dhana Raj , Onagbola Ebenezer O , Salyani Masoud , Stelinski Lukasz L 
Published: May 2009

AbstractBACKGROUND: Asian citrus psyllid (ACP), Diaphorina citri Kuwayama, transmits the causal bacteria of the devastating citrus disease huanglongbing (HLB). Because of the variation in spatial and temporal uptake and systemic distribution of imidacloprid applied to citrus trees and its degradation over time in citrus trees, ACP adults and nymphs are exposed to concentrations that may not cause immediate mortality but rather sublethal effects. The objective of this laboratory study was to determine the effects of sublethal concentrations of imidacloprid on ACP life stages.RESULTS: Feeding by ACP adults and nymphs on plants treated daily with a sublethal concentration (0.1 µg mL−1) of imidacloprid significantly decreased adult longevity (8 days), fecundity (33%) and fertility (6%), as well as nymph survival (12%) and developmental rate compared with untreated controls. The magnitude of these negative effects was directly related to exposure duration and concentration. Furthermore, ACP adults that fed on citrus leaves treated systemically with lethal and sublethal concentrations of imidacloprid excreted significantly less honeydew (7–94%) compared with controls in a concentration‐dependent manner suggesting antifeedant activity of imidacloprid.CONCLUSIONS: Sublethal concentrations of imidacloprid negatively affect development, reproduction, survival and longevity of ACP, which likely contributes to population reductions over time. Also, reduced feeding by ACP adults on plants treated with sublethal concentrations of imidacloprid may potentially decrease the capacity of ACP to successfully acquire and transmit the HLB causal pathogen. Copyright © 2009 Society of Chemical Industry
Current transport modeling of carbon nanotube field effect transistors
Authors: Srivastava Ashok , Marulanda Jose M. , Xu Yao , Sharma Ashwani K. 
Published: May 2009

AbstractIn the present work, analytical modeling equations describing the current transport in carbon nanotube field effect transistors (CNT‐FETs) have been developed from physical electronics, which have strong dependence on the chiral vector and device geometries. These model equations for the CNT‐FETs have been compared with the available experimental data and then used to generate voltage transfer characteristics of basic logic devices based on complementary CNT‐FETs. The voltage transfer characteristics exhibit characteristics similar to the voltage transfer characteristics of standard CMOS logic devices, with a sharp transition near the logic threshold voltage depending on the input conditions. (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Deposition temperature effects on the characteristics of a‐Si:H deposited by pulsed DC magnetron sputtering
Authors: Cherfi R. , Abdelmoumene A. , Kechouane M. , Rahal A. , Aoucher M. , Mohammed‐Brahim T. 
Published: May 2009

AbstractIn this study, the deposition temperature effects on the properties of hydrogenated amorphous silicon films are reported. The a‐Si:H thin films were deposited by DC magnetron sputtering technique, according to a new protocol of deposition. This last consists of a successively several thin layers deposition separated by a relaxation time between them without stopping plasma (a layer by layer procedure). The a‐Si:H samples elaborated at various deposition temperatures are characterized by a rather high microstructure parameter (ranging between 0.23 and 0.77), indicating that most of hydrogen incorporated into the films is in the form of dihydride bonds. An important increase in the proportion of the polyhydride complexes might favor the porous character of the material and therefore a decrease of its compactness. Otherwise, in the range of deposition temperature 300–400 °C, the microstructural parameters “R2000, R2090” and the dark conductivity “σd” present a particular evolution. Indeed, the earlier studies in our laboratory showed that the layers deposited according to the usual protocol, remain always amorphous until temperatures lower than 600 °C, we thus arrived at temperatures less significant (350 °C) to make a beginning of crystallization. (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Theoretical study on the photodoping effects in La1–xSrx MnO3/SrNby Ti1–yO3 p–n heterojunction
Authors: Liao Leng , Jin Kui‐juan , Lu Hui‐bin , Qiu Jie , Han Peng , Zhang Li‐li 
Published: May 2009

AbstractThe dynamic process of photodoping effect in the heterojunction of La0.9Sr0.1MnO3/SrNb0.01Ti0.99O3 is revealed theoretically. By solving Poisson Equation and time‐dependent carrier continuity equations, the evolutions of the carrier concentrations and the electrical potential are obtained self‐consistently. The calculated photovoltage evolution agrees well with the experimental data. The present results demonstrate that the large variation of carrier concentration mainly locates in the space‐charge region of the oxide heterojunction. It means that the photodoping effect mainly occurs in the space‐charge region of heterojunction. (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)