bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mutation screening of the HDC gene in Chinese Han patients with Tourette syndrome
Authors: Lei Jing , Deng Xiong , Zhang Jie , Su Linyan , Xu Hongbo , Liang Hui , Huang Xian , Song Zhi , Deng Hao 
Published: November 2011

AbstractTourette Syndrome (TS) is a complex neuropsychiatric disorder characterized by vocal and motor tics. While environmental causes have been proposed to play a role, genetic factors are believed to be the main determinants of the disorder and its clinical manifestations. Recently, a heterozygous W317X mutation in the histidine decarboxylase gene (HDC) was reported to be responsible for TS in a two‐generation pedigree. To investigate whether the HDC gene play a role in TS in Chinese Han population, we performed genetic analysis of the coding region of the HDC gene in 100 Chinese Han patients with TS. Three variants were found including a C > T transition (IVS1 + 52C > T), a novel C > A transition (c.426C > A) in exon 4, and a novel G > A transition (c.1743G > A) in exon 12, both predicted with no amino acid change. Extended analysis was conducted in a total of 120 TS patients and 240 sex, age, and ethnicity matched healthy controls. No significant differences in genotypic and allele distribution between patients and controls for these three variants (P = 0.274, P = 1.000 and P = 0.632 for genotypic distribution, respectively; P = 0.143, P = 1.000 and P = 0.582 for allele distribution, respectively) were observed, suggesting variants in the HDC gene may play little or no role in TS susceptibility in Chinese Han population. © 2011 Wiley Periodicals, Inc.
Inflamm‐aging of the stem cell niche: Breast cancer as a paradigmatic example
Authors: Bonafè Massimiliano , Storci Gianluca , Franceschi Claudio 
Published: November 2011

AbstractInflamm‐aging is a relatively new terminology used to describe the age‐related increase in the systemic pro‐inflammatory status of humans. Here, we represent inflamm‐aging as a breakdown in the multi‐shell cytokine network, in which stem cells and stromal fibroblasts (referred to as the stem cell niche) become pro‐inflammatory cytokine over‐expressing cells due to the accumulation of DNA damage. Inflamm‐aging self‐propagates owing to the capability of pro‐inflammatory cytokines to ignite the DNA‐damage response in other cells surrounding DNA‐damaged cells. Macrophages, the major cellular player in inflamm‐aging, amplify the phenomenon, by broadcasting pro‐inflammatory signals at both local and systemic levels. On the basis of this, we propose that inflamm‐aging is a major contributor to the increase in cancer incidence and progression in aged people. Breast cancer will be presented as a paradigmatic example for this relationship.
The challenge of enzyme cost in the production of lignocellulosic biofuels
Authors: Klein‐Marcuschamer Daniel , Oleskowicz‐Popiel Piotr , Simmons Blake A. , Blanch Harvey W. 
Published: November 2011

AbstractWith the aim of understanding the contribution of enzymes to the cost of lignocellulosic biofuels, we constructed a techno‐economic model for the production of fungal cellulases. We found that the cost of producing enzymes was much higher than that commonly assumed in the literature. For example, the cost contribution of enzymes to ethanol produced by the conversion of corn stover was found to be $0.68/gal if the sugars in the biomass could be converted at maximum theoretical yields, and $1.47/gal if the yields were based on saccharification and fermentation yields that have been previously reported in the scientific literature. We performed a sensitivity analysis to study the effect of feedstock prices and fermentation times on the cost contribution of enzymes to ethanol price. We conclude that a significant effort is still required to lower the contribution of enzymes to biofuel production costs. Biotechnol. Bioeng. 2012; 109:1083–1087. © 2011 Wiley Periodicals, Inc.
The effect of biofilm permeability on bio‐clogging of porous media
Authors: Pintelon Thomas R.R. , Picioreanu Cristian , van Loosdrecht Mark C.M. , Johns Michael L. 
Published: November 2011

AbstractA 3D Biofilm model, appropriate for complex porous media support structures, is successfully modified such that non‐zero permeability of biofilms structures is enabled. A systematic study is then conducted into the influence of biofilm permeability on overall biomass growth rate. This reveals a significant influence at large biofilm concentrations; even when the permeability of the biomass is 1.25% of that of the free pore space, biomass accumulation increased by a factor of ∼3 over 40 h. The effect is shown to be retained when allowing for biomass detachment or erosion as a consequence of adjacent velocity shear. We conclude that biofilm permeability should be included in biofilm models and that further experimental work is required to better describe the link between biofilm permeability and local microstructure. Biotechnol. Bioeng. 2012; 109:1031–1042. © 2011 Wiley Periodicals, Inc.
Controlled release of IGF‐I from a biodegradable matrix improves functional recovery of skeletal muscle from ischemia/reperfusion
Authors: Hammers David W. , Sarathy Apurva , Pham Chantal B. , Drinnan Charles T. , Farrar Roger P. , Suggs Laura J. 
Published: November 2011

AbstractIschemia/reperfusion (I/R) injury is a considerable insult to skeletal muscle, often resulting in prolonged functional deficits. The purpose of the current study was to evaluate the controlled release of the pro‐regenerative growth factor, insulin‐like growth factor‐I (IGF‐I), from a biodegradable polyethylene glycol (PEG)ylated fibrin gel matrix and the subsequent recovery of skeletal muscle from I/R. To accomplish this, the hind limbs of male Sprague–Dawley rats were subjected to 2‐h tourniquet‐induced I/R then treated with saline, bolus IGF‐I (bIGF), PEGylated fibrin gel (PEG‐Fib), or IGF‐I conjugated PEGylated fibrin gel (PEG‐Fib‐IGF). Functional and histological evaluations were performed following 14 days of reperfusion, and muscles from 4‐day reperfusion animals were analyzed by Western blotting and histological assessments. There was no difference in functional recovery between saline, bIGF, or PEG‐Fib groups. However, PEG‐Fib‐IGF treatment resulted in significant improvement of muscle function and structure, as observed histologically. Activation of the PI3K/Akt pathway was significantly elevated in PEG‐Fib‐IGF muscles, compared to PEG‐Fib treatment, at 4 days of reperfusion, suggesting involvement of the pathway PI3K/Akt as a mediator of the improved function. Surprisingly, myoblast activity was not evident as a result of PEG‐Fib‐IGF treatment. Taken together, these data give evidence for a protective role for the delivered IGF. These results indicate that PEG‐Fib‐IGF is a viable therapeutic technique in the treatment of skeletal muscle I/R injury. Biotechnol. Bioeng. 2012; 109:1051–1059. © 2011 Wiley Periodicals, Inc.
Role of positron emission tomography–computed tomography in predicting survival after neoadjuvant chemotherapy and surgery for oesophageal adenocarcinoma
Authors: Gillies R S , Middleton M R , Han C , Marshall R E K , Maynard N D , Bradley K M , Gleeson F V 
Published: November 2011

Abstract

Background
Positron emission tomography combined with computed tomography (PET–CT) is increasingly being used in the staging of oesophageal cancer. Some recent reports suggest it may be used to predict survival. None of these studies, however, reported on the prognostic value of PET–CT performed before neoadjuvant chemotherapy and surgery. The aim of this study was to determine whether pretreatment PET–CT could predict survival.

Methods
Consecutive patients with oesophageal adenocarcinoma who underwent PET–CT before neoadjuvant chemotherapy and resection were included. Maximum standardized uptake value (SUVmax), fluorodeoxyglucose (FDG)-avid tumour length and the presence of FDG-avid local lymph nodes were determined for all patients. Kaplan–Meier survival analysis was performed and multivariable analysis used to identify independent prognostic factors.

Results
A total of 121 patients were included (mean age 63 years, 97 men) of whom 103 underwent surgical resection. On an intention-to-treat basis, overall survival was significantly worse in patients with FDG-avid local lymph nodes (P &lt; 0·001). SUVmax and FDG-avid tumour length did not predict survival (P = 0·276 and P = 0·713 respectively). The presence of FDG-avid local lymph nodes was an independent predictor of poor overall survival (hazard ratio (HR) 4·75, 95 per cent confidence interval 2·14 to 10·54; P &lt; 0·001) and disease-free survival (HR 2·97, 1·40 to 6·30; P = 0·004).

Conclusion
The presence of FDG-avid lymph nodes, but not SUVmax or FDG-avid tumour length, was an independent adverse prognostic factor.
ChemInform Abstract: Bonding Situation in “Early‐Late” Transition Metal Complexes Cl3M—M′(PCl3)4 (M: Ti, Zr, Hf; M′: Co, Rh, Ir) —Theoretical Study for a Ligand Fine Tuning of M—M′ Bonds
Authors: Takagi Nozomi , Krapp Andreas , Frenking Gernot 
Published: November 2011

AbstractDFT calculations
ChemInform Abstract: Polymorphism in Alkali Metal Uranyl Nitrates: Synthesis and Crystal Structure of γ‐K(UO2)(NO3)3.
Authors: Jouffret Laurent J. , Krivovichev Sergey V. , Burns Peter C. 
Published: November 2011

AbstractThe title compound is obtained hydrothermally from an aqueous solution containing UO2(NO3)2, V2O5, HCl, and KOH (autoclave, 220 °C, 48 h).
ChemInform Abstract: [Te8]2[Ta4O4Cl16]: A Two‐Dimensional Tellurium Polycation Obtained via Ionic Liquid‐Based Synthesis.
Authors: Freudenmann Dominic , Feldmann Claus 
Published: November 2011

AbstractBlack crystals of the title compound are prepared from a mixture of Te, TeCl4, TaOCl3, and TaCl5 in the ionic liquid [bmim]Cl (sealed glass tubes,190 °C, 10 d; ≈35% yield).
ChemInform Abstract: Synthetic, Structural, and Spectroscopic Investigations of K3Nb8O21‐Type Complex Oxides K3MTa7O21 (M: Ti, Zr).
Authors: Odynets Ievgen V. , Babaryk Artem A. , Baumer Vyacheslav N. , Slobodyanik Nikolay S. , Shiskin Oleg V. 
Published: November 2011

AbstractThe title compounds are prepared by a flux‐supported synthesis in molten K2Mo2O7 starting with a mixture of K2CO3, TiO2 or ZrO2, Ta2O5, and MoO3 (Pt crucible, 1373 K, 18 h).
ChemInform Abstract: Preparation and Structural Characterization of RuII‐DMSO and RuIII‐DMSO‐Substituted α‐Keggin‐Type Phosphotungstates, [PW11O39RuIIDMSO]5‐ and [PW11O39RuIIIDMSO]4‐, and Catalytic Activity for Water Oxidation.
Authors: Sadakane Masahiro , et al. et al. 
Published: November 2011

AbstractThe RuII‐ and RuIII‐substituted α‐Keggin‐type phosphotungstates (IV) and (V) are characterized by XANES, cyclic voltammetry, UV/VIS, IR, 31P NMR, 183W NMR, and 1H NMR spectroscopy.
ChemInform Abstract: 1,3‐Dipolar Cycloaddition of Unstabilized N‐Methyl Azomethine Ylide to Nitrobenzene Anellated with Azoles.
Authors: Starosotnikov Alexey M. , Bastrakov Maxim A. , Pechenkin Sergey Yu. , Leontieva Margarita A. , Kachala Vadim V. , Shevelev Svyatoslav A. 
Published: November 2011

AbstractA general method for the synthesis of the compounds (IV) and (VI) is developed.
ChemInform Abstract: Regioselective Radical Bromoallylation of Allenes Leading to 2‐Bromo‐Substituted 1,5‐Dienes.
Authors: Kippo Takashi , Fukuyama Takahide , Ryu Ilhyong 
Published: November 2011

AbstractThe process is applied to various substrates to produce highly functionalized diene structures of synthetic importance.
ChemInform Abstract: Fluoroanalogues of DDT: Superacidic BF3—H2O Catalyzed Facile Synthesis of 1,1,1‐Trifluoro‐2,2‐diarylethanes and 1,1‐Difluoro‐2,2‐diarylethanes.
Authors: Prakash G. K. Surya , Paknia Farzaneh , Mathew Thomas , Mloston Gzregorz , Joschek Jens P. , Olah George A. 
Published: November 2011

AbstractThe reaction substrate (I) with various arenes is mediated by BF3·Et2O or TFA with comparable yields.
ChemInform Abstract: Gold‐Catalyzed Deacylative Cycloisomerization Reactions of 3‐Acylindole/ynes: A New Approach for Carbazole Synthesis.
Authors: Wang Lu , Li Guijie , Liu Yuanhong 
Published: November 2011

AbstractUnder conditions A), ring closure to carbazole structures is accompanied by fragmentation which results in loss of an acylium ion intermediate.
ChemInform Abstract: Enantioselective Synthesis of Cyclic Thioureas via Mannich Reaction and Concise Synthesis of Highly Optically Active Methylthioimidazolines: Discovery of a More Potent Antipyretic Agent.
Authors: Jiang Xianxing , Wang Yiqing , Zhang Gen , Fu Dan , Zhang Futing , Kai Ming , Wang Rui 
Published: November 2011

AbstractBiologically active methylthioimidazolines are obtained by reaction of (III) with MeI.
ChemInform Abstract: Synthesis of New Spiro[1,4,2‐dioxazole‐5,3′‐indolin]‐2′‐one by 1,3‐Dipolar Cycloaddition
Authors: Bouhfid Rachid , Joly Nicolas , Essassi El Mokhtar , Lequart Vincent , Massoui Mohamed , Martin Patrick 
Published: November 2011

Abstractof isatin derivatives with nitrile oxide derived from benzaldoxime (II)
ChemInform Abstract: Synthesis of 4,N‐Diaryl‐2‐methyl‐5‐oxo‐1,4,5,6,7,8‐hexahydroquinoline‐3‐carboxamides.
Authors: Gein V. L. , Kazantseva M. I. , Kurbatova A. A. 
Published: November 2011

AbstractThe three‐component condensation of cyclohexanedione (I) with aromatic benzaldehydes (II) and N‐arylacetoacetamides (III) in the presence of ammonium acetate proceeds under solvent‐free conditions in short reaction times to afford title compounds (IV) in moderate to good yields.
ChemInform Abstract: A Simple and Highly Efficient Iron Catalyst for a [2 + 2 + 2] Cycloaddition to Form Pyridines.
Authors: Wang Chunxiang , Li Xincheng , Wu Fan , Wan Boshun 
Published: November 2011

AbstractCycloaddition of various diynes with unactivated nitriles occurs in the presence of a new catalyst system using zinc dust as reductant.
ChemInform Abstract: Copper‐Catalyzed Dehydrogenative Cross‐Coupling Reactions of N‐para‐Tolylamides Through Successive C—H Activation: Synthesis of 4H‐3,1‐Benzoxazines.
Authors: Xiong Tao , Li Yan , Bi Xihe , Lv Yunhe , Zhang Qian 
Published: November 2011

AbstractThe reaction occurs in the presence of Selectfluor and water by successive intermolecular C—H activated dehydrogenative cross‐coupling reaction of benzylic methyl C(sp3)—H and aromatic C(sp2)—H bonds, and subsequent intramolecular C—O bond formation.
ChemInform Abstract: Synthesis, Insecticidal Activities, and Molecular Docking Studies of 1,5‐Disubstituted‐1,3,5‐hexahydrotriazine‐2‐(N‐nitro)imines.
Authors: Sun Chuan‐Wen , Wang Hai‐Feng , Zhu Jun , Yang Ding‐Rong , Jin Jia , Xing Jia‐Hua 
Published: November 2011

AbstractAll synthesized compounds are screened in vitro for their insecticidal activity against Pseudaletia separate Walker.
ChemInform Abstract: Reaction of Selenium Dichloride with Allyl Phenyl Ether.
Authors: Musalov M. V. , Potapov V. A. , Amosova S. V. 
Published: November 2011

AbstractThe regio‐ and stereoselective reaction of selenium dichloride with allyl phenyl ether (I) yields a new heterocyclic compound, dihydrobenzoxaselenine (II).
ChemInform Abstract: A Novel Membrane‐Permeant cADPR Antagonist Modified in the Pyrophosphate Bridge.
Authors: Qi N. , Jung K. , Wang M. , Na L. X. , Yang Z. J. , Zhang L. R. , Guse A. H. , Zhang L. H. 
Published: November 2011

AbstractThe title compound (I) and its epimer with (S) configuration at the chiral phosphorus atom show different biological activities with regard to Ca2+ signaling.
ChemInform Abstract: Osteogenic Constituents from Pterospermum acerifolium Willd. Flowers.
Authors: Dixit Preety , Khan Mohd Parvez , Swarnkar Gaurav , Chattopadhyay N. , Maurya Rakesh 
Published: November 2011

AbstractIsolation and identification of two new (I), (II), and new lactone (III), pterospermins A‐C, along with 14 known compounds are described.
ChemInform Abstract: Design and Pharmacological Evaluation of PF‐4840154, a Non‐Electrophilic Reference Agonist of the TrpA1 Channel.
Authors: Ryckmans Thomas , et al. et al. 
Published: November 2011

AbstractConduction of a high throughput screening leads to the identification of a novel class of non‐covalent TrpA1 agonists that is utilized as a replacement for the well established yet problematic reference agonist Mustard Oil.
ChemInform Abstract: Magnetic Nanoparticles: Study of Magnetic Heating and Adsorption/Desorption for Biomedical and Environmental Applications
Authors: Pham Hoai Linh , Do Hung Manh , Tran Dai Lam , Le Van Hong , Nguyen Xuan Phuc , Nguyen Anh Tuan , Nguyen Thanh Ngoc , Vu Anh Tuan 
Published: November 2011

AbstractReview: 25 refs.
ChemInform Abstract: Dendrimer‐Encapsulated Nanoparticles: New Synthetic and Characterization Methods and Catalytic Applications.
Authors: Myers V. Sue , Weir Michael G. , Carino Emily V. , Yancey David F. , Pande Surojit , Crooks Richard M. 
Published: November 2011

AbstractReview: new results since last review in 2005; 116 refs.
ChemInform Abstract: Romidepsin (Istodax, NSC 630176, FR901228, FK228, Depsipeptide): A Natural Product Recently Approved for Cutaneous T‐Cell Lymphoma
Authors: VanderMolen Karen M. , McCulloch William , Pearce Cedric J. , Oberlies Nicholas H. 
Published: November 2011

AbstractReview: discovery, mechanism of action, synthetic studies; 75 refs.
Endothelial paxillin and focal adhesion kinase (FAK) play a critical role in neutrophil transmigration
Authors: Parsons Sean A. , Sharma Ritu , Roccamatisi Dawn L. , Zhang Hong , Petri Björn , Kubes Paul , Colarusso Pina , Patel Kamala D. 
Published: November 2011

AbstractDuring an inflammatory response, endothelial cells undergo morphological changes to allow for the passage of neutrophils from the blood vessel to the site of injury or infection. Although endothelial cell junctions and the cytoskeleton undergo reorganization during inflammation, little is known about another class of cellular structures, the focal adhesions. In this study, we examined several focal adhesion proteins during an inflammatory response. We found that there was selective loss of paxillin and focal adhesion kinase (FAK) from focal adhesions in proximity to transmigrating neutrophils; in contrast the levels of the focal adhesion proteins β1‐integrin and vinculin were unaffected. Paxillin was lost from focal adhesions during neutrophil transmigration both under static and flow conditions. Down‐regulating endothelial paxillin with siRNA blocked neutrophil transmigration while having no effect on rolling or adhesion. As paxillin dynamics are regulated partly by FAK, the role of FAK in neutrophil transmigration was examined using two complementary methods. siRNA was used to down‐regulate total FAK protein while dominant‐negative, kinase‐deficient FAK was expressed to block FAK signaling. Disruption of the FAK protein or FAK signaling decreased neutrophil transmigration. Collectively, these findings reveal a novel role for endothelial focal adhesion proteins paxillin and FAK in regulating neutrophil transmigration.
EGRI and FOSB gene expressions in cancer stroma are independent prognostic indicators for epithelial ovarian cancer receiving standard therapy
Authors: Kataoka Fumio , Tsuda Hiroshi , Arao Tokuzo , Nishimura Sadako , Tanaka Hideo , Nomura Hiroyuki , Chiyoda Tatsuyuki , Hirasawa Akira , Akahane Tomoko , Nishio Hiroshi , Nishio Kazuto , Aoki Daisuke 
Published: November 2011

AbstractStromal components interact with cancer cells to promote growth and metastasis. The purpose of this study was to identify genes expressed in stroma, which could provide prognostic information in epithelial ovarian cancer (EOC). Seventy‐four patients were included. We performed gene expression profiling and confirmed array data using RT‐PCR and immunohistochemistry. By microarray analysis, 52 candidate genes associated with progression free survival (PFS) were identified (P < 0.005). Expression of the early growth response 1 (EGR1) and FBJ murine osteosarcoma viral oncogene homolog B (FOSB) genes was further analyzed. Array data were confirmed by RT‐PCR and multivariate analysis demonstrated that both EGR1 and FOSB expression in cancer stroma, and EGR1 expression in cancer are independent prognostic factors in EOC. Immunohistochemically, EGR1 protein is localized in cancer cells and α‐smooth muscle actin positive stromal fibroblasts. The EGR1 and FOSB expression in stromal cells and EGR1 expression in cancer cells are prognostic indicators in EOC. © 2011 Wiley Periodicals, Inc.
Preliminary findings on the use of metadoxine for the treatment of alcohol dependence and alcoholic liver disease
Authors: Leggio Lorenzo , Kenna George A. , Ferrulli Anna , Zywiak William H. , Caputo Fabio , Swift Robert M. , Addolorato Giovanni 
Published: November 2011

ObjectiveMetadoxine is approved in Europe for alcohol intoxication and is also indicated for alcoholic liver disease (ALD). This study aims to investigate the use of metadoxine as a potential pharmacotherapy for alcohol dependence (AD).MethodsThis is a retrospective study of 94 outpatients with AD, who received metadoxine for alcohol intoxication and were assessed for alcohol consumption, craving [Visual Analog Scale (VAS)] and liver‐related and alcohol‐related biomarkers [aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma‐glutamyl‐transpeptidase, mean corpuscular volume].ResultsRange of metadoxine dose was 500–2000 mg/day, with a mean dose of 1277(s.d.290) mg/day, and for a period of 2–42 days, with a mean period of 8.9(s.d.7.0) days. Follow‐up data were available for 52 patients (55.3%); 35(67.3%) patients were completely abstinent. There was a significant decrease in drinks per week, even after substituting baseline drinking as follow‐up data for dropouts (p < 0.001) and examining drinking pre‐treatment and post‐treatment for those who did not achieve abstinence (p < 0.001). There was a significant decrease in the VAS (p < 0.001) and a significant improvement in the AST/ALT ratio (p = 0.03).DiscussionDespite important limitations, this study represents a further preliminary observation suggesting metadoxine as a novel alcohol pharmacotherapy, including in alcohol‐dependent patients with ALD. Copyright © 2011 John Wiley & Sons, Ltd.
Liquid Quasicrystals
Authors: Ungar Goran , Percec Virgil , Zeng Xiangbing , Leowanawat Pawaret 
Published: November 2011

AbstractIn the first part, this brief review discusses the discovery of the first example of supramolecular dendritic liquid quasicrystal, which represents also the first example of soft quasicrystal. In the second part, we show that soft quasicrystals generated from supramolecular spheres are scattered through libraries of self‐assembling dendrons, dendrimers, and dendronized polymers. The supramolecular spheres forming soft quasicrystals are generated via at least two different mechanisms, and are chiral. Generation of quasicrystals from other organic building blocks is also discussed. Finally, potential applications in electronics, sensors, and as ionic liquid‐based nanoreactors are also mentioned.
Adding some notes to the “Music of Containment”. Discussion of paper: “The Music of Containment: Addressing the participants in mother–infant psychoanalytic treatment”
Authors: Moggio Françoise 
Published: November 2011

AbstractThinking about the psychoanalytical process in parent–infant psychotherapy is the purpose of Björn Salomonsson's article. He proposes to consider that containment is the core of the treatment and that musicality is his main vehicle. His thought is linked with the research on primary intersubjectivity and is so exciting for all the parent–infant therapists. For myself, I emphasize the use of the psychoanalytical concept of affects rather than emotions, and I present my understanding of the transference phenomena with the part of the infantile sexuality of all the participants.