bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effectiveness of Long-Term Agalsidase Alfa Therapy in the Treatment of Fabry Nephropathy
Authors: Feriozzi Sandro , Torras Joan , Cybulla Markus , Nicholls Kathy , Sunder-Plassmann Gere , West Michael 
Published: January 2012

Summary

Background and objectives
Fabry disease is a rare X-linked disease with multisystemic manifestations. This study investigated the effectiveness of long-term enzyme replacement therapy with agalsidase alfa in Fabry nephropathy treatment.

Design, setting, participants, & measurements
In this observational study, data on patients receiving agalsidase alfa (0.2 mg/kg every other week) were extracted from the Fabry Outcome Survey, an international registry of patients with Fabry disease. Serum creatinine and estimated GFR (eGFR) at baseline and after ≥5 years of treatment were assessed; 24-hour urinary protein excretion and BP measurements were also reviewed. The eGFR was calculated using the Chronic Kidney Disease Epidemiology Collaboration formula. Patients with an eGFR <30 ml/min per 1.73 m2 were excluded.

Results
Renal function was assessed in 208 patients (mean enzyme replacement therapy, 7.4 years; range, 5.0–11.2 years). Mean yearly change in eGFR was −2.2 ml/min per 1.73 m2 in men and −0.7 ml/min per 1.73 m2 in women (95% confidence limits, −2.8; −1.7 and −1.4; 0.0, respectively). Patients with 24-hour protein excretion >1 g/24 h had poorer renal function at baseline and follow-up compared with patients with protein excretion of 500–1000 mg/24 h or with proteinuria <500 mg/24 h. Renal function was worse in patients with baseline arterial hypertension, and there was a more rapid yearly decline compared with normotensive patients.

Conclusions
This study suggests that long-term agalsidase alfa therapy is able to stabilize the rate of Fabry nephropathy progression in women and is associated with a mild to moderate decline of renal function in men.
Use of 11C-methionine PET parametric response map for monitoring WT1 immunotherapy response in recurrent malignant glioma
Authors: Chiba Yasuyoshi , Kinoshita Manabu , Okita Yoshiko , Tsuboi Akihiro , Isohashi Kayako , Kagawa Naoki , Fujimoto Yasunori , Oji Yusuke , Oka Yoshihiro , Shimosegawa Eku , Morita Satoshi , Hatazawa Jun , Sugiyama Haruo , Hashimoto Naoya , Yoshimine Toshiki 
Published: January 2012

Object
Immunotherapy targeting the Wilms tumor 1 (WT1) gene product is a promising treatment modality for patients with malignant gliomas, and there have been reports of encouraging results. It has become clear, however, that Gd-enhanced MR imaging does not reflect prognosis, thereby necessitating a more robust imaging evaluation system for monitoring response to WT1 immunotherapy. To meet this demand, the authors performed a voxel-wise parametric response map (PRM) analysis of 11C-methionine PET (MET-PET) in WT1 immunotherapy and compared the data with the overall survival after initiation of WT1 immunotherapy (OSWT1).

Methods
Fourteen patients with recurrent malignant glioma were included in the study, and OSWT1 was compared with: 1) volume and length change in the contrast area of the tumor on Gd-enhanced MR images; 2) change in maximum uptake of 11C-methionine; and 3) a more detailed voxel-wise PRM analysis of MET-PET pre- and post-WT1 immunotherapy.

Results
The PRM analysis was able to identify the following 3 areas within the tumor core: 1) area with no change in 11C-methionine uptake pre- and posttreatment; 2) area with increased 11C-methionine uptake posttreatment (PRM+MET); and 3) area with decreased 11C-methionine uptake posttreatment. While the results of Gd-enhanced MR imaging volumetric and conventional MET-PET analysis did not correlate with OSWT1 (p = 0.270 for Gd-enhanced MR imaging length, p = 0.960 for Gd-enhanced MR imaging volume, and p = 0.110 for MET-PET), the percentage of PRM+MET area showed excellent correlation (p = 0.008) with OSWT1.

Conclusions
This study describes the limited value of Gd-enhanced MR imaging and highlights the potential of voxel-wise PRM analysis of MET-PET for monitoring treatment response in immunotherapy for malignant gliomas. Clinical trial registration no.: UMIN000002001.
Supracerebellar transtentorial approach—resection of the tentorium instead of an opening—to provide broad exposure of the mediobasal temporal lobe: anatomical aspects and surgical applications
Authors: de Oliveira Jean G. , Párraga Richard Gonzalo , Chaddad-Neto Feres , Ribas Guilherme Carvalhal , de Oliveira Evandro P. L. 
Published: January 2012

Object
The aim of this study was to describe the surgical anatomy of the mediobasal aspect of the temporal lobe and the supracerebellar transtentorial (SCTT) approach performed not with an opening, but with the resection of the tentorium, as an alternative route for the neurosurgical management of vascular and tumoral lesions arising from this region.

Methods
Cadaveric specimens were used to illustrate the surgical anatomy of the mediobasal region of the temporal lobe. Demographic aspects, characteristics of lesions, clinical presentation, surgical results, follow-up findings, and outcomes were retrospectively reviewed for patients referred to receive the SCTT approach with tentorial resection.

Results
Ten patients (83%) were female and 2 (17%) were male. Their ages ranged from 6 to 59 years (mean 34.5 ± 15.8 years). All lesions (3 posterior cerebral artery aneurysms, 3 arteriovenous malformations, 3 cavernous malformations, and 3 tumors) were completely excluded or resected. After a mean follow-up period of 143 months (range 10–240 months), the mean postoperative Glasgow Outcome Scale score was 4.9.

Conclusions
Knowledge of the surgical anatomy provides improvement for microsurgical approaches. The evolution from a small opening to a resection of the tentorium absolutely changed the exposure of the mediobasal aspect of the temporal lobe. The SCTT approach with tentorial resection is an excellent alternative route to the posterior part of mediobasal aspect of the temporal lobe, and it was enough to achieve the best neurosurgical management of tumoral and vascular lesions located in this area.
Direct venous spinal reabsorption of cerebrospinal fluid: a new concept with serial magnetic resonance cisternography in rabbits
Authors: Biceroglu Huseyin , Albayram Sait , Ogullar Sabri , Hasiloglu Zehra Isik , Selcuk Hakan , Yuksel Odhan , Karaaslan Burak , Yildiz Can , Kiris Adem 
Published: January 2012

Object
For nearly 100 years it has been believed that the main reabsorption of CSF occurs in arachnoid projections into the superior sagittal sinus, but a significant number of experiments and cases conflict with this hypothesis. According to recently published studies, CSF is permanently produced and absorbed in the whole CSF system. Clusters of arachnoidal villi, which are speculated to have a role in the reabsorption of CSF, have recently been revealed in the dorsal root of the spinal nerves. Huge absorptive surface areas of microvessels have been suggested to serve a putative role in reabsorption. The authors' aim was to observe direct venous connections between the subarachnoid space and the perispinal veins.

Methods
Eleven adult (6 months old) New Zealand white male rabbits weighing approximately 3.0 kg each were used in this experiment. After obtaining precontrast MR cisternography images, subarachnoid access was gained percutaneously via a cisternal approach by using a 20-gauge intravenous indwelling cannula. One rabbit died as a result of brainstem trauma during percutaneous cannulation before contrast administration, but contrast agent was still injected to see the possible MR imaging results of spinal CSF reabsorption after death. Magnetic resonance imaging was performed at 15, 60, 120, and 180 minutes after the administration of contrast agent. After intramuscular injections of anesthetic, 2 rabbits died 120 and 150 minutes after contrast injection, but the MR imaging study at 180 minutes after contrast injection was still performed.

Results
Direct connections between the subarachnoid space and the perispinal veins were observed in all rabbits during serial MR cisternography. The enhancement power was not affected by the amount of injected contrast agent or by cervical or lumbar penetration but was increased at higher contrast concentrations or upon seizure (physical activity).

Conclusions
Extracranial reabsorption of CSF has been finally proved with direct radiological confirmation of spinal venous reabsorption of CSF using serial MR cisternography. The authors believe that this study can help to develop a more accurate model of CSF dynamics, which will allow understanding of many CSF-related diseases, as well as the development of new strategies for treatment.
Preparation of Jam from Sapota (<i>Achras zapota</i>)
Authors: Ahmed T , Burhanuddin M , Haque MA , Hossain MA 
Published: January 2012

An attempt was made to develop sapota jam to assess its prospect in marketability. The fruits were collected from local market and the pulp was extracted in the laboratory. Then the pulp was analyzed monthly for proximate composition. The proximate analysis of sapota pulp showed moisture 70.07%, ascorbic acid 8.90 mg/100g, pH 5.10, TSS 19.4% and total sugar 16.07%. No special change of ingredients was found during two months of storage. But, a little change was observed after four months. The products (jam) with three different formulations (50%, 75% and 100% pulp of the standard formula) were prepared. Sodium benzoate was added as preservative in a required quantity. These products were packed in appropriate container. A taste panel consisting 10 panelists adjudged the acceptability of the samples. The consumers’ preferences were measured by statistical analysis. Among the samples, jam made with 75% pulp of the standard formula (sample A2) was adjudged the best product by the panelists. Keywords: Jam; sapota; ascorbic acid; sugar; Achras zapotaDOI: http://dx.doi.org/10.3329/agric.v9i1-2.9473 The Agriculturists 2011; 9(1&2): 1-7
Association of <i>Phomopsis vexans</i> with Eggplant (<i>Solanum melongena</i>) Seeds, Seedlings and its Management
Authors: Islam MR , Meah MB 
Published: January 2012

Incidence of Phomopsis vexans on farmers’ eggplant seeds collected from different areas of Bangladesh varied from 0.0 to 7.5%. The highest incidence of P. vexans (7.50 %) was recorded in cultivar Dohazari and Rupgonj L collected from Chandanish and Rupgonj, respectively. No incidence of P. vexans was observed in the cultivar Katabegun and Jessore-L collected from Pabna and Monirampur, respectively. Very low seed infection was recorded in the cultivar Shingnath, Bijoy, Ishurdi-Land Longla-long collected respectively from Chandina, Modhukhali, Ishurdi and Kulaura. Seeds collected from HRC of BARI had higher seed infection by P. vexans. Seed selection had a significant impact on the incidence of P. vexans. Use of apparently healthy seed was found effective in controlling damping off, tipover and seedling blight of eggplant. The least incidence of P. vexans (1.25%) and the highest germination (86.75%) were recorded in apparently healthy seed as against 6.5% seed infection and 60% seed germination recorded in farmer’s seed. In the net house, the least incidence of damping off, tipover and seedling blight were recorded in case of apparently healthy seed. Seed treatment with hot water (56 °C for 15 minutes), garlic (Allium cepa L) bulb extract and Allamanda (Allamanda cathertica L) leaf extract, Trichoderma harzianum CP, Trichoderma harzianum T22 and Bavistin were found promising in controlling seedling diseases in the nursery and in increasing the seed germination. Combinations of apparently healthy seed (T2), treated with garlic bulb extract (T3) and soil treated with T. harzianum CP (T11) completely controlled damping off, tipover and seedling blight in the nursery bed and increased seed germination by 48.83% over control. Keywords: Eggplant; incidence; seed; seedling; disease; Phomopsis vexans; management DOI: http://dx.doi.org/10.3329/agric.v9i1-2.9474 The Agriculturists 2011; 9(1&2): 8-17
Genetic Variability and Path Analysis of Groundnut (<i>Arachis hypogaea</i> L.)
Authors: Zaman MA , Tuhina-Khatun M , Ullah MZ , Moniruzzamn M , Alam KH 
Published: January 2012

An experiment was conducted at the Research farm of Regional Agricultural Research Station, BARI, Hathazari, Chittagong during Rabi season (December to April), 2009-2010 for estimation of genetic variability, genetic parameters and correlation coefficient among different yield components in a randomized block design with three replications. Thirty four groundnut genotypes were tested in the experiment. Highly significant variations were observed among the genotypes for all the characters studied. The highest genetic coefficient of variation was observed for karnel yield per hectare, followed by karnel yield per plant, branches per plant, immature and mature nuts per plant, 100 kernal weight and plant height. The highest heritability was observed in karnel yield per pant (95.08%), followed by karnel yield per hectare (94.38%), 100 kernal weight (87.01%), immature and mature nuts per plant (82.24%, 80.32%), branches per plant (79.54%) and 100 nut weight (78.98%), while high values of genetic advance were obtained in all the characters except days to maturity and days to 50% flowering. The seed yield per plant showed the highly significant and positive association with nut size, number of nuts per plant, karnel size and days to 50% flowering. The number of mature nuts per plant had high positive direct effect on seed yield per hectare followed by nut size, shelling percentage, days to 50% flowering and days to maturity. Therefore, branches per plant, plant height, nuts per plant, nut size, karnel size, days to 50% flowering, shelling percentage and days to maturity were identified to be the important characters which could be used in selection for yield. Keywords: Genetic variability; heritability; genetic advance; groundnut DOI: http://dx.doi.org/10.3329/agric.v9i1-2.9476 The Agriculturists 2011; 9(1&2): 29-36
Efficacy of Foliar Spray with Seven Fungicides and a Botanical to Control Scab (<i>Elsinoe fawcettii</i>) and Dieback (<i>Colletotrichum gloeosporioides</i>) Diseases of Lemon
Authors: Siddiquee TA , Islam MR , Aminuzzaman FM , Faruq AN , Islam MM 
Published: January 2012

An investigation was conducted in a six year old lemon (Citrus limon) garden during March to September 2007 to find out the effect of foliar spray with seven fungicides and a botanical on the severity of citrus scab (Elsinoe fawcettii) and dieback (Colletotrichum gloeosporioides) of the crop. The tested fungicides were Dinthane M 45 (0.30%), Rovral 50 WP (0.10%), Bavistin 50 WP (0.10%), Champion 77 WP (0.20%), Cupravit 50 WP (0.20%), Tilt 250 EC (0.25%), Proud 250 EC (0.25%) and the botanical allamanda (Allamanda cathartica) leaf extract (1:4). The results showed that the fungicides and allamanda leaf extract are effective to achieve significant reduction in severity of scab and dieback diseases, and to increase fruit yield of lemon. The reduction of Percent Disease Index (PDI) of scab on leaf and fruit, and that of dieback ranged 26.45-83.87, 49.01-60.20 and 35.22- 58.01%, respectively after six months of first spray. The relationship of increase in fruit yield was directly and linearly correlated with percentage of reduction in severity of dieback diseases. Based on reduction of disease severity and increase of fruit yield, Allamanda leaf extract was noted as most effective material followed by Bavistin 50 WP, Tilt 250 EC, Cupravit 50 WP and Dithane M-45. Keywords: Citrus; scab; dieback; lemon; fungicide; botanical; control DOI: http://dx.doi.org/10.3329/agric.v9i1-2.9484 The Agriculturists 2011; 9(1&2): 99-105
Effects of Temperature, Rainfall and Relative Humidity on Leaf Spot of Jackfruit Seedling and its Eco-friendly Management
Authors: Chowdhury MSM , Hossain I 
Published: January 2012

Experiments were carried out during 2005-08 to study the effect of weather prevalence of seedling diseases of jackfruit in different areas of Bangladesh and develop an environment friendly disease management practice. Leaf spot causal pathogen Colletotrichum gloeosporioides was identified. Incidence and severity of leaf spot at seedling stage were studied and significant variations were observed depending on weather factors. Occurrence of seedling diseases was significantly influenced by temperature, rainfall and relative humidity. Comparative effectiveness of BAU-biofungicide either alone or in combination with two fungicides viz. Cupravit and Bavistin were evaluated on jackfruit in the nursery. Among the treatments applied, Trichoderma harzianum based BAU-Biofungicide showed best result in controlling leaf spot disease. Keywords: Jackfruit seedling; leaf spot disease; ecofriendly management; BAU-Biofungicide DOI: http://dx.doi.org/10.3329/agric.v9i1-2.9487The Agriculturists 2011; 9(1&2): 126-136
Antibacterial and larvicidal potentials of <i>Derris indica</i> (Lamk.) Bennet. extractives
Authors: Mondal Omar Ali , Haque M Emdadul , Islam Nurul 
Published: January 2012

Chloroform extracts of the fruit shell, leaves, root bark, root wood, seeds, stem bark and stem wood of Derris indica were tested for their antibacterial and larvicidal potentials. Except the seed extract all other extracts offered activity against 15 pathogenic bacteria. The fruit shell extract showed activity against B. cereus, S.-β- haemolyticus and S. typhi; the leaf extract against Klebsiella sp. only; the root bark against B. cereus, B. megaterium, B. subtilis, S. -β- haemolyticus, S. typhi, S. dysenteriae and S. sonnei; the root wood extract against B. sereus, B. megaterium, B. subtilis, S. -β- haemolyticus, S. typhi, S. dysenteriae, S. shiga, S. sonnei, Klebsiella sp. and P. aeruginosa; the stem bark extract against B. cereus, B. subtilis, S. -β- haemolyticus and S. sonnei and the stem wood extract against B. cereus, B. megaterium, B. subtilis, S. -β- haemolyticus, S. typhi and S. dysenteriae. According to the intensity of activity against the selected bacteria the D. indica extracts could be arranged in a descending order of root wood> root bark> stem wood> stem bark> fruit shell> leaf extract. The minimum inhibitory concentrations (MICs) of the chloroform extract of root wood of D. indica were 128 μg/ml against S. -β- haemolyticus, B. megaterium and S. dysenteriae and 64 μg/ml against B. cereus; for the stem wood extract 128 μg/ml against S. -β- haemolyticus, B. megaterium, B. cereus and B. subtilis, and 64 μg/ml against S. dysenteriae. The root bark, root wood, seed and stem wood extracts showed efficacy against the 3rd instar larvae of Musca domestica with LC50 values in a descending order of root wood (3615.92 ppm) > seed (5538.07 ppm) > stem wood (12139.40 ppm) > root bark (16721.24 ppm). Key words: Chloroform extract; Derris indica; antibacterial and larvicidal activity. DOI: http://dx.doi.org/10.3329/ujzru.v29i1.9460 UJZRU 2010; 29(1): 17-22
Determination of immune response against alum-precipitated fowl cholera vaccine in the quail, <i>Coturnix japonica</i>
Authors: Iqbal MT , Haque MH , Sarker S , Islam MA , Choudhury KA 
Published: January 2012

The immune response of a formalin-inactivated alum-precipitated fowl cholera vaccine (FCV) was evaluated in quails, Coturnix japonica (Order: Galliformes and Family: Mimidae). All quails, irrespective of sex and 8-weeks-old were immunized with 5×107CFU/ml/quail subcutaneously (SC) and intramuscularly (IM). A Booster immunization was given with similar dose and routes at 15 days after primary immunization in groups A and B while group C served as unimmunized control. Pre-immunized sera were collected from all groups of birds to assay the primary antibody levels in them. Sera of the immunized and control quails were collected at 15 and 30 days post immunization. The degree of immunity produced in each group of quails following primary and secondary immunizations were determined by measuring their serum antibody titres using passive haemagglutination assay (PHA) test. The level of antibody was significantly increased both primary and booster immunization in immunized quails as determined by PHA titres. Two weeks after final immunization, the quails were challenged with a virulent isolate of fowl cholera and immunized quails conferred 100% protection while all the control quails were dead within 10 days post challenge. Key words: Fowl cholera; alum-precipitated vaccine; immune response; PHA test; quail DOI: http://dx.doi.org/10.3329/ujzru.v29i1.9467 UJZRU 2010; 29(1): 57-59
Payer de sa personne. Leiris entre Rimbaud et Mallarmé
Authors: Kaufmann Vincent 
Published: January 2012

Leiri's writing can be considered, on the whole, as haunted by the possibility of an act which would not be a failure, which would not be only a
semblance, a rhetorical one : how truly pay the price ? This is maybe the question Leiris has never been able to actually answer. When he attempts suicide (« Fade suprême ») , he finds himself fascinated by Mallarmés Livre (Fibrilles). And when he goes to war (in 1939) y he feels less like taking action than like entering a legend whose premature hero would he himself : a hero who has not yet acted, and who will never do so. (Biffures.)
Trois notes, sur trois carnets de peintres
Authors: Raillard Georges 
Published: January 2012

Painter's Notebooks have commonly been considered as a laboratory for paintings. Miro' 's Notebooks still have such a function. And, as Picasso's and
Groborne's Notebooks that we examine here, they contain « modern » research too in which we consider three main aspects : series, illisibility , « rébus ». Notebooks are at the same time « opera » and « opus ». Still strong ideological interpretors are menacing them, willing to find in them the « secret » explanation of the paintings, and to deduct the visible from the readable.
II peint, il bave. Sur l'œuvre écrite de Salvador Dali
Authors: Joseph Frédérique 
Published: January 2012

FRÉDÉRIQUE JOSEPH : Liquid paste, mastered flow,
HE PAINTS, HE SLOBBERS. stumbling stain, Dali writes ON SALVADOR DALI'S the difficulty of mastering pain-
PAINTING AND WRITING ting in his diary. The word of
imagination changes and creates, between milk and teeth, bones and liquids, forms and rhythms, even up to cannibalism. Deformity wears the action ; the canvas becomes a battle field for ghostly shapes. Picture is where painting solves.
Le philosophe et ses diables. Les romans du philosophe sous la Monarchie de Juillet
Authors: Navet Georges 
Published: January 2012

The philosopher and his demons: the novel of the philosopher during the july monarchy.
This study traces different novelistic incarnations of the figure of the philosopher through the works of various writers at the period. Satanic and/or angelic, political and/or mystical, heir or loner, with or without disciples, fictional philosophers highlight the novelist's relation to philosophy and philosophy' s role in literature.
Nietzsche et Baudelaire
Authors: Le Rider Jacques 
Published: January 2012

Nietzsche and baudelaire.
This study deals with the relationship of Nietzsche to Baudelaire — the figure and his works — from a « first » encounter in 1883 through to Nietzsche's breakdown. Nietzsche's passionate ambivalence to a figure in which he recognised an alter-ego is traced, in posthumous texts and major works, through the themes of decadence, Wagnerism, French vs German culture, and aesthetic theory.
Le roman comme enthymème
Authors: Sève Bernard 
Published: January 2012

The novel as enthymeme.
This study of the implicit in novelistic structure (through Faulkner's "The Sound and the Fury" and Perec's "La vie mode d'emploi") in terms of the imperfect syllogism shows that 1) an enthymematic structure is fundamental to the novel's success and pleasurable effect 2) an enthymeme is like a novel inasmuch as its implicit premises make it an effective and rational argumentative tool.