bluuebunny/crossref_metadata_2025_split huggingface dataset:
Energy efficient data dissemination in wireless sensor network enabled IoT using domain‐adaptive message passing graph neural network
Authors: Shiny G. Susan , Ram R. Saravana , J Rajeshkumar , Muthalakshmi M. 
Published: May 2024

SummaryIn the past few years, restricted wireless sensor networks (WSNs) enabled the Internet of Things (IoT) have attracted significant attention and expansion to enhance service delivery and resource efficiency. Dissemination is a service offered by WSN that uses radio transmission and over‐the‐air programming for updating the deployed sensor nodes through online. The centralized data dissemination methods are replaced by the distributed approaches because they affect the drawbacks of a single point of failure, no scalability, and insecurity. Therefore, an Energy Efficient Protocol for Data Dissemination in Wireless Sensor network‐enabled IoT using Domain‐Adaptive Message Passing Graph Neural Network (EEP‐WSN‐IoT‐DMPGNN) is proposed in this paper. The nodes are formed as clusters utilizing the Deep Fuzzy Curriculum Clustering (DFCC) technique that rewards nodes belonging to a given cluster. By using the Crayfish Optimization Algorithm (COA), the Cluster Head (CH) selection optimally chose the ideal CH and satisfies the multiple objective functions, such as energy, delay, traffic density, and distance. Afterward, domain‐adaptive Message Passing Graph Neural Network (DMPGNN) based routing protocol is developed, the input given to the routing protocol includes a sink, action history, future node, and maximum‐distance node, which attains enhanced data transfer in the chosen path. The proposed technique attains a lower no. of dead nodes, lower energy consumption, and higher Network Lifetime while analyzed with existing techniques, such as routing technique depending on deep learning for effectual data transmission in 5G WSN communication (DL‐RPDT‐WSN), Reinforcement‐Learning base energy effectual optimized routing protocol in WSN (RL‐EERP‐WSN), and Energy‐efficient intellectual routing method for IoT‐enabled WSN (EIR‐IoT‐WSN), respectively.
A review of carbon and phosphorus ratios in fresh water ecosystems dominated by phytoplankton: Effects of climate and geography
Authors: Ayub Gohar , Su Jinzhu , Su Yuping , Zheng Luwei , Zhou Yuanyuan , Rehman Sami ur , Zahir Muhammad 
Published: May 2024

AbstractIn freshwater systems, carbon, nitrogen, and phosphorus are essential macroelements. Changing ecological communities as a result of anthropogenic activity and climate change has become a global issue. C:P has been demonstrated to be a trustworthy and sensitive assay for detecting and monitoring single or multiple species in a wide range of samples. We look at how C:P can be utilized to manage and reduce eutrophication and harmful algal blooms (HABs) in freshwater environments in this review work. Recent research show how C:P has been shown to be a useful strategy for gathering complete data in freshwater ecosystem studies. The total number of papers in ScienceDirect from 2000 to 2023 with the terms “carbon and phosphorus ratios, fresh water ecosystems, and phytoplankton” in the title, abstract, or keywords was acquired for this review. Based on the number of published research demonstrating an increased understanding of the basic scientific concepts behind the carbon and phosphorus ratio, the overall temporal trend in publications on the ratio showed a steady growth. Compared to eutrophic Lake Victoria, which had a C:P of 149, mesotrophic Lakes Malawi and Kivu had a ratio of 263. Applying the carbon‐to‐phosphorus ratio to lake and reservoir eutrophication assessment is feasible, and the increasing C:P ratio serves as a prime indicator for the initiation of lake and reservoir reoligotrophication. Our findings establish the framework for future study into the relationship between organic nutrients and eutrophication, as well as the ecological ramifications of these relationships in freshwater systems. Furthermore, our prediction was that increases in C:P would change the structure of phytoplankton communities.
Development of a maintenance scheduling method for power generators considering large penetration of variable renewable energy sources and system inertia
Authors: Segawa Shuhei , Ogimoto Kazuhiko , Azuma Hitoshi , Isonaga Akira , Fukutome Suguru 
Published: May 2024

AbstractConventional methods to schedule power generators maintenance aim to secure enough supply reserve margin to the power system when its power generators have to go under maintenance. However, the use of such methods in scenarios of large penetration of VRE, might be problematic. This is because in such scenarios conventional scheduling methods might inadvertently concentrate maintenance operations when residual demand is particularly low, creating situations in which there is insufficient supply‐demand balancing capability and inertia to operate the power system properly. In this study, we present the development of a new method to schedule generator maintenance that ensure inertia and balancing capability constraints, and show its effectiveness.
Lanthanoid Semiquinonate/Tropolonate Complexes: Redox Chemistry and Luminescence
Authors: Dunstan Maja A. , Suryadevara Nithin , Cameron Lee , Gable Robert W. , Massi Massimiliano , Boskovic Colette 
Published: May 2024

AbstractHeteroleptic lanthanoid (Ln = Eu, Gd, Tb, Dy, Ho and Yb) complexes featuring hydro‐tris(1‐pyrazolyl)borate (Tp−) ligands combined with the bidentate O‐donor ligands tropolonate (trop−) or 3,5‐di‐tertbutylseminquinonate (dbsq⋅−) have been synthesized and investigated. Despite the similarity of the bidentate O‐donor trop− and dbsq⋅− ligands, and the lanthanoid coordination geometries, the complexes [LnTp2dbsq] (Ln‐dbsq) and [LnTp2trop] (Ln‐trop) exhibit markedly different redox and photophysical properties. The electrochemistry of Ln‐dbsq is dominated by processes associated with the readily redox‐active dbsq⋅− moiety. In contrast, the relative redox inactivity of Ln‐trop allows for the observation of the Eu(III) to Eu(II) reduction process. Photophysical measurements reveal no sensitized emission for the Ln‐dbsq family, while the trop− antenna ligand is able to sensitize emission in the visible range for Eu(III) and Ho(III), and in the near‐infrared for Ho(III) and Yb(III).
Transition‐Metal‐Catalyzed Reactions Involving Trifluoro Diazo Compounds and Their Surrogates
Authors: Wang Yeming , Zhang Chaoqun , Li Shizhe , Liu Lihui , Feng Xiaodong , Liu Zhaohong 
Published: May 2024

AbstractFluorinated organic compounds represent an important and growing family of active ingredients in various fields, including material science, pharmaceutical chemistry and biological science. Developing efficient synthetic methods toward fluorinated organic compounds have attracted much attention. In recent years, transition‐metal catalyzed reaction of trifluoro diazo compounds were a powerful and convenient approach to afford trifluoromethyl‐ and difluoromethyl‐substituted compounds of value. In this review, the recent progress on transition‐metal‐catalyzed reactions involving trifluoro diazo compounds and their surrogates via trifluoromethylated transition‐metal carbene complex is described in the sequence of 2,2,2‐trifluorodiazoethane as carbene precursor, ethyl 3‐trifluoro‐2‐diazo‐propionate as carbene precursor, trifluoroethylamine hydrochloride or amines as the CF3CHN2 surrogate as well as trifluoro aldehydes/ketones N‐sulfonylhydrazones as the trifluoro diazo compounds surrogate.
Amidation of β‐Keto Sulfonyl Fluorides via C−C Bond Cleavage
Authors: Liang Hui , Liu Qian , Zhao Xueyan , He Tianyu , Luo Jinyue , Huang Shenlin 
Published: May 2024

AbstractA simple protocol for amide bond construction using β‐keto sulfonyl fluorides (BKSFs) as the acyl surrogates has been achieved. The reaction of BKSFs with a range of amines could be performed in presence of N‐bromosuccinimide (NBS), affording various amides with diverse functionalities. Preliminary mechanistic studies revealed that the dibromo‐substituted sulfonyl fluorides could be the key intermediate in this amidation process.
Investigating the kinetics of small alcohol oxidation reactions using platinum supported on a doped niobium suboxide support
Authors: Black‐Araujo Keenan , Nguyen Katherine , Esfahani Reza Alipour Moghadam , Easton E. Bradley 
Published: May 2024

AbstractPlatinum nanoparticles deposited on a silicon‐doped niobium suboxide support provided the catalyst known as Pt/NbOS. This was compared to the commercial Pt/C electrocatalyst in the ethanol and methanol oxidation reactions for use in direct alcohol fuel cells. Cyclic voltammetry and electrochemical impedance spectroscopy demonstrate that the employment of the metal oxide support provides higher peak oxidation currents and smaller charge transfer resistances during alcohol oxidation. Carbon monoxide (CO) stripping experiments showed enhanced removal of CO by Pt/NbOS compared to Pt/C. Pt/NbOS shows its smallest apparent activation energies of 13.3 and 11.9 J mol‐1, for methanol and ethanol oxidation respectively, which are 38% and 27% lower than those of Pt/C at the same potentials. This increased activity of Pt/NbOS is attributed to the strong metal‐support interactions between the active Pt nanoparticles and the NbOS support which demonstrate its utility in replacing Pt/C in methanol and ethanol fuel cells.
A critical review of polymer support‐based shape‐stabilized phase change materials for thermal energy storage applications
Authors: Bidiyasar Rahul , Kumar Rohitash , Jakhar Narendra 
Published: May 2024

AbstractPhase change materials (PCMs) have drawn considerable attention in recent years due to their capability of storing and releasing thermal energy during phase transformation. However, traditional PCMs face challenges like limited thermal conductivity, leakage while phase transformation from solid to liquid, thermal degradation, and durability. Researchers have concentrated on creating shape‐stabilized PCMs (SSPCMs) employing polymers as the supporting matrix to overcome these difficulties and incorporating highly thermally conductive additives to improve thermal conductivity. Compared to conventional PCMs, polymer‐based SSPCMs are often more flexible, lightweight, and durable and may be easily customized according to specific applications. Various factors like PCM loading, thermal cyclability, cost‐effectiveness and environmental concerns must be considered while constructing polymer‐based SSPCMs. This review paper comprehensively explored various polymers, including polyurethane, polyacrylates, polyolefin, and so on, as promising supporting materials for SSPCMs due to their relatively high mechanical strength, compatibility with PCM, excellent thermal stability, and chemical resistance. Natural polymers like chitosan, cellulose, and starch are also considered for eco‐friendly solutions. We have also discussed about specific properties of each polymer, their cost‐effectiveness, and the environmental impact while developing such SSPCMs to guide researchers in material selection. Applications of polymer‐based SSPCMs in solar energy storage, medical devices, building materials, electronics, transportation industry, and waste heat recovery are briefly discussed. Finally, some future development areas have been discussed to attract the attention of new researchers in this field. The information provided in this review will assist readers in understanding polymer‐based SSPCM and selecting their desired polymer for support material with diverse application methods.
Macrophage proteomic analysis of covalent immobilization of hyaluronic acid and graphene oxide on CoCr alloy in a tribocorrosive environment
Authors: Sánchez‐López L. , Chico B. , García‐Alonso Maria Cristina , Lozano Rosa M. 
Published: May 2024

AbstractIn this work, a sequential covalent immobilization of graphene oxide (GO) and hyaluronic acid (HA) is performed to obtain a biocompatible wear‐resistant nanocoating on the surface of the biomedical grade cobalt‐chrome (CoCr) alloy. Nanocoated CoCr surfaces were characterized by Raman spectroscopy and electrochemical impedance spectroscopy (EIS) in 3 g/L HA electrolyte. Tribocorrosion tests of the nanocoated CoCr surfaces were carried out in a pin on flat tribometer. The biological response of covalently HA/GO biofunctionalized CoCr surfaces with and without wear‐corrosion processes was studied through the analysis of the proteome of macrophages. Raman spectra revealed characteristic bands of GO and HA on the functionalized CoCr surfaces. The electrochemical response by EIS showed a stable and protective behavior over 23 days in the simulated biological environment. HA/GO covalently immobilized on CoCr alloy is able to protect the surface and reduce the wear volume released under tribocorrosion tests. Unsupervised classification analysis of the macrophage proteome via hierarchical clustering and principal component analysis (PCA) revealed that the covalent functionalization on CoCr enhances the macrophage biocompatibility in vitro. On the other hand, disruption of the HA/GO nanocoating by tribocorrosion processes induced a macrophage proteome which was differently clustered and was distantly located in the PCA space. In addition, tribocorrosion induced an increase in the percentage of upregulated and downregulated proteins in the macrophage proteome, revealing that disruption of the covalent nanocoating impacts the macrophage proteome. Although macrophage inflammation induced by tribocorrosion of HA/GO/CoCr surfaces is observed, it is ameliorated by the covalently grafting of HA, which provides immunomodulation by eliciting downregulations in characteristic pro‐inflammatory signaling involved in inflammation and aseptic loosening of CoCr joint arthroplasties. Covalent HA/GO nanocoating on CoCr provides potential applications for in vivo joint prostheses led a reduced metal‐induced inflammation and degradation by wear‐corrosion.
Synthesis and characterization of TiNbZrMo medium‐entropy bio‐composites: Microstructure, mechanical properties, and in vitro degradation
Authors: Say Yakup 
Published: May 2024

AbstractThis study reports the synthesis and characterization of hydroxyapatite (HA)‐based bio‐composites reinforced with varying amounts (by weight, 1–15 wt.%) of bio‐medium entropy alloy (BioMEA) for load‐bearing implant applications. BioMEA powders consisting of Ti, Nb, Zr, and Mo were mechanically alloyed for 100 h and subsequently added to HA using powder metallurgy techniques. To show the effect of BioMEA, the microstructure, density, and mechanical tests have been conducted and the synthesized BioMEA was characterized by scanning electron microscope (SEM), x‐ray diffractometer (XRD), and Fourier‐transform infrared spectroscopy (FTIR) analysis. In addition, in vitro degradation behavior and bioactivity analyses of bio‐composites have been conducted. XRD analysis revealed the formation of BioMEA after 20 h of mechanical alloying. The highest density value of 2.47 g/cm3 was found in 15 wt.% BioMEA‐reinforced bio‐composite. The addition of BioMEA reinforcement led to a significant increase in hardness and tensile strength values, with the highest values observed at 15 wt.% reinforcement. Compression tests demonstrated a significant increase in compressive strength and deformation capability of the bio‐composites with the highest values observed at 15 wt.% BioMEA addition. The highest toughness of 7.68 kJ/m2 was measured in 10 wt.% MEA‐reinforced bio‐composites. The produced bio‐composite materials have an elastic modulus between 3.5–5.5 GPa, which may provide a solution to the stress shielding problems caused by the high elastic modulus of metallic implant materials. The most severe degradation occurred in 15 wt.% MEA‐reinforced bio‐composites, and the effect of degradation caused a decrease in Ca and an increase in Ti‐Ni‐Zr‐Mo in all bio‐composites. These findings suggest that HA/BioMEA bio‐composites have the potential to be developed as advanced biomaterials with moderate mechanical and biological properties for load‐bearing implant applications.
Noninvasive therapy of brain cancer using a unique systemic delivery methodology with a cancer terminator virus
Authors: Bhoopathi Praveen , Mannangatti Padmanabhan , Pradhan Anjan K. , Kumar Amit , Maji Santanu , Lang Frederick F. , Klibanov Alexander L. , Madan Esha , Cavenee Webster K. , Keoprasert Timothy , Sun Dong , Bjerkvig Rolf , Thorsen Frits , Gogna Rajan , Das Swadesh K. , Emdad Luni , Fisher Paul B. 
Published: May 2024

AbstractPrimary, glioblastoma, and secondary brain tumors, from metastases outside the brain, are among the most aggressive and therapeutically resistant cancers. A physiological barrier protecting the brain, the blood–brain barrier (BBB), functions as a deterrent to effective therapies. To enhance cancer therapy, we developed a cancer terminator virus (CTV), a unique tropism‐modified adenovirus consisting of serotype 3 fiber knob on an otherwise Ad5 capsid that replicates in a cancer‐selective manner and simultaneously produces a potent therapeutic cytokine, melanoma differentiation‐associated gene‐7/interleukin‐24 (MDA‐7/IL‐24). A limitation of the CTV and most other viruses, including adenoviruses, is an inability to deliver systemically to treat brain tumors because of the BBB, nonspecific virus trapping, and immune clearance. These obstacles to effective viral therapy of brain cancer have now been overcome using focused ultrasound with a dual microbubble treatment, the focused ultrasound‐double microbubble (FUS‐DMB) approach. Proof‐of‐principle is now provided indicating that the BBB can be safely and transiently opened, and the CTV can then be administered in a second set of complement‐treated microbubbles and released in the brain using focused ultrasound. Moreover, the FUS‐DMB can be used to deliver the CTV multiple times in animals with glioblastoma growing in their brain thereby resulting in a further enhancement in survival. This strategy permits efficient therapy of primary and secondary brain tumors enhancing animal survival without promoting harmful toxic or behavioral side effects. Additionally, when combined with a standard of care therapy, Temozolomide, a further increase in survival is achieved. The FUS‐DMB approach with the CTV highlights a noninvasive strategy to treat brain cancers without surgery. This innovative delivery scheme combined with the therapeutic efficacy of the CTV provides a novel potential translational therapeutic approach for brain cancers.
Predictive role of early treatment dynamics of HBV RNA and HBcrAg for HBeAg seroconversion in children with chronic hepatitis B
Authors: Lai Xin , OuYang Wenxian , Li Shuangjie , Qiu Jun , Zhang Hui , Jiang Tao , Qin Xiaomei , Tang Lian , Gu Yingping , Yao Zhenzhen , Peng Songxu 
Published: May 2024

AbstractThis study aimed to assess the predictive capacity of emerging serological markers, serum HBV RNA and HBcrAg, for HBeAg seroconversion in children with HBeAg‐positive chronic hepatitis B (CHB). Treatment‐naïve HBeAg‐positive CHB children who admitted to the Liver Disease Center of Hunan Children's Hospital between April 2021 and September 2022 and received treatment with the combined entecavir and interferon‐alpha treatment were recruited. Serum HBV RNA and HBcrAg were measured at baseline and Weeks 12, 24, and 48 of treatment. Our study showed that serum HBV RNA (HR = 0.71, 95% CI: 0.56–0.91, p = 0.006), HBcrAg (HR = 0.60, 95% CI: 0.43–0.84, p = 0.003), and HBsAg (HR = 0.49, 95%CI: 0.36–0.69, p < 0.001) at Week 12 were independent predictors of HBeAg seroconversion. ROC curve analysis presented that serum HBV RNA decline value (ΔHBV RNA) at Week 36 and HBcrAg decline value (ΔHBcrAg) at Week 12 (AUC = 0.871, p = 0.003 and AUC = 0.810, p = 0.003, respectively) could effectively predict HBeAg seroconversion. Furthermore, the optimal critical values were determined and the children with ΔHBV RNA > 3.759 log10 copies/mL at Week 36 or ΔHBcrAg >0.350 log10 U/mL at Week 12 more likely to achieve HBeAg seroconversion. The serum HBV RNA and HBcrAg provide new insights into the treatment of CHB in children. Early assessment of serum HBV RNA and HBcrAg during treatment can assist clinical decision‐making and optimize individualized therapeutic approaches.
Increased occurrence of two intrinsic atmospheric circulations in Asia during the boreal summer
Authors: Oh Sae‐Yoon , Yeh Sang‐Wook , Jeong Yong‐Cheol , Song Hajoon , Lee Min‐Hee 
Published: May 2024

AbstractThe k‐means clustering of reanalysis datasets is used to classify the intrinsic atmospheric circulation in Asia based on the daily geopotential height of 500 hPa during the boreal summer (June, July and August) for 1958–2020. Among the total clusters of atmospheric circulation patterns in Asia, two distinct clusters of atmospheric circulation are characterized by a significant increasing trend in occurrence. They correspond to different zonal wave numbers (1–2 vs. 3–4) of atmospheric circulation in the mid‐to‐high latitudes of the Northern Hemisphere, and their associated sea surface temperature structures are not the same in the tropical Pacific and the North Atlantic. Further analysis indicates that two clusters of atmospheric circulation alter the amount of summer monsoon precipitation in East Asia, and an increasing amount of precipitation in southern China in recent decades could be explained by the combined effect of an increasing trend in the frequency of occurrence of two clusters of atmospheric circulation. Finally, a long‐term simulation of the Community Earth System Model version 2 suggests that anthropogenic forcing may be responsible for the increasing trend of occurrence of the two atmospheric circulations in Asia.
3,4‐methylenedioxymethamphetamine (MDMA)‐assisted psychotherapy: what the pharmacist needs to know
Authors: Gallo Alexander T. , Fitzgerald Paul B. 
Published: May 2024

AbstractPurpose of ReviewOn 1 July 2023, the Therapeutic Goods Administration approved 3,4‐methylenedioxymethamphetamine (MDMA)‐assisted psychotherapy for the treatment of post‐traumatic stress disorder (PTSD). Accordingly, the purpose of this review is to provide an overview of MDMA and what pharmacists should know as this treatment emerges.Sources of InformationEMBASE, MEDLINE, and CINAHL databases were searched to provide an overview narrative synthesis of the literature on MDMA, relevant to pharmacists.Key FindingsCytochrome P450 2D6 is involved in the metabolic pathway of MDMA, an enzyme inhibited by a number of drugs used in the pharmacological management of PTSD (e.g. selective serotonin reuptake inhibitors). Co‐administration of these drugs with MDMA can lead to increases in plasma MDMA concentrations. Additionally, inhibition of the serotonin transporter can inhibit the uptake of MDMA into the presynaptic terminal, dampening the effects of MDMA and potentially, limiting the effectiveness of MDMA‐assisted psychotherapy. Accordingly, these drugs are typically withdrawn prior to treatment with MDMA. While selective serotonin reuptake inhibitor/serotonin noradrenaline reuptake inhibitor drugs with MDMA are unlikely to cause serotonin toxicity, monoamine oxidase inhibitors can. Other drugs, such as caffeine, alcohol, over‐the‐counter medicines, and complimentary/alternative medicines, can also interact with MDMA.ConclusionWith a detailed knowledge of the pharmacology of MDMA, pharmacists may play a role in MDMA‐assisted psychotherapy by collecting a detailed medication history and assisting clinicians in the withdrawal of interacting medicines.