bluuebunny/crossref_metadata_2025_split huggingface dataset:
MiR-34a-5p suppresses cutaneous squamous cell carcinoma progression by targeting SIRT6
Authors: Chen Sai , Yuan Muxing , Chen Hongxia , Wu Tong , Wu Tianqi , Zhang Dongmei , Miao Xu , Shi Jian 
Published: May 2024

AbstractCutaneous squamous cell carcinoma (cSCC) is a malignant tumor originating from epidermal or appendageal keratinocytes, with a rising incidence in recent years. Understanding the molecular mechanism driving its development is crucial. This study aims to investigate whether miR-34a-5p is involved in the pathogenesis of cSCC by targeting Sirtuin 6 (SIRT6).The expression levels of miR-34a-5p and SIRT6 were determined in 15 cSCC tissue specimens, 15 normal tissue specimens and cultured cells via real-time polymerase chain reaction (RT-qPCR). Pearson’s correlation analysis was conducted to evaluate the relationship between miR-34a-5p and SIRT6 expression levels in cSCC tissues. A431 and SCL-1 cells were transfected with miR-34a-5p mimic, negative control or miR-34a-5p mimic together with recombinant plasmids containing SIRT6 gene. Cell counting kit-8, clone formation assay, wound healing assay, and flow cytometry were employed to assess the effects of these transfections on proliferation, migration, and apoptosis, respectively. The interaction between miR-34a-5p and SIRT6 was characterized using a dual-luciferase reporter assay.MiR-34a-5p expression was down-regulated in cSCC tissues significantly, while the SIRT6 expression was the opposite. A negative correlation was observed between the expression of miR-34a-5p and SIRT6 in cSCC tissues. Furthermore, overexpression of miR-34a-5p led to a significant reduction in the proliferation and migration abilities of A431 and SCL-1 cells, accompanied by an increase in apoptosis levels and a decrease in SIRT6 expression levels. MiR-34a-5p was identified as a direct target of SIRT6. Importantly, overexpression of SIRT6 effectively counteracted the inhibitory effect mediated by miR-34a-5p in cSCC cells.Our findings suggest that miR-34a-5p functions as a tumor suppressor in cSCC cells by targeting SIRT6.
Risk factors and clinical significance of lower perigastric lymph node metastases in Siewert type II and III esophagogastric junction adenocarcinoma: a retrospective cohort study
Authors: Qi Xinyu , Liu Maoxing , Xu Kai , Tan Fei , Gao Pin , Yao Zhendan , Zhang Nan , Yang Hong , Zhang Chenghai , Xing Jiadi , Cui Ming , Su Xiangqian 
Published: May 2024

Abstract
Background
No consensus has been concluded with regarding to the scope of lymph node (LN) dissection for Siewert type II and III adenocarcinoma of the esophagogastric junction (AEG). This study aimed to explore risk factors for lower perigastric LN (LPLN) metastases (including no. 4d, 5, 6, and 12a LN stations) and analyze the indications for LPLN dissection.

Methods
In total, 302 consecutive patients with Siewert type II and III AEG who underwent total gastrectomy (TG) were enrolled. The logistic regression model was used to perform uni- and multivariate analyses of risk factors for LPLN metastases. Kaplan–Meier curves were used for survival analysis, and log-rank tests were used for group comparisons. Basing on the guidelines of Japanese Gastric Cancer Association, the LN metastases (LNM) as well as the efficiency index (EI) of each LN station was further evaluated.

Results
The independent risk factors for LPLN metastases in patients with Siewert type II and III AEG were distance from the esophagogastric junction (EGJ) to the distal end of the tumor (> 4.0 cm), preoperative carcinoembryonic antigen (CEA) ( +), pT4 stage, and HER-2 ( +). LPLN metastases was an independent risk factor for overall survival following TG. The LNM and EI of LPLN were 8.6% and 2.31%, respectively. The LNM of LPLN > 10% under the stratification of the distance from the EGJ to the distal end of the tumor (> 4.0 cm), pT4, preoperative CEA ( +), and HER-2 ( +) exhibited EI values of 3.55%, 2.09%, 2.51%, and 3.64%, respectively.

Conclusions
LPLN metastases was a malignant factor for the prognosis of patients with Siewert type II and III AEG. For patients with preoperative CEA ( +), pT4 stage, HER-2 ( +), and the distance from the EGJ to the distal end of the tumor (> 4.0 cm), TG with LPLN dissection is prioritized for clinical recommendation.
Interactive digital tools to support empowerment of people with cancer: a systematic literature review
Authors: Tuominen Leena , Leino-Kilpi Helena , Poraharju Jenna , Cabutto Daniela , Carrion Carme , Lehtiö Leeni , Moretó Sónia , Stolt Minna , Sulosaari Virpi , Virtanen Heli 
Published: May 2024

Abstract
Purpose
To identify and synthesise interactive digital tools used to support the empowerment of people with cancer and the outcomes of these tools.

Methods
A systematic literature review was conducted using PubMed, CINAHL, Web of Science, Cochrane, Eric, Scopus, and PsycINFO databases in May 2023. Inclusion criteria were patient empowerment as an outcome supported by interactive digital tools expressed in study goal, methods or results, peer-reviewed studies published since 2010 in cancer care. Narrative synthesis was applied, and the quality of the studies was assessed following Joanna Briggs Institute checklists.

Results
Out of 1571 records screened, 39 studies published in 2011–2022 with RCT (17), single-arm trial (15), quasi-experimental (1), and qualitative designs (6) were included. A total of 30 interactive digital tools were identified to support empowerment (4) and related aspects, such as self-management (2), coping (4), patient activation (9), and self-efficacy (19). Significant positive effects were found on empowerment (1), self-management (1), coping (1), patient activation (2), and self-efficacy (10). Patient experiences were positive. Interactivity occurred with the tool itself (22), peers (7), or nurses (7), physicians (2), psychologists, (2) or social workers (1).

Conclusion
Interactive digital tools have been developed extensively in recent years, varying in terms of content and methodology, favouring feasibility and pilot designs. In all of the tools, people with cancer are either active or recipients of information. The research evidence indicates positive outcomes for patient empowerment through interactive digital tools. Thus, even though promising, there still is need for further testing of the tools.
Theoriebezüge in der systemischen Therapie
Authors: Wagner Elisabeth 
Published: May 2024

ZusammenfassungDie enorme Binnendifferenzierung der Systemischen Therapie bietet zwar eine nützliche Vielfalt an Interventionsmöglichkeiten, führt auf der theoretischen Ebene jedoch zu Unvereinbarkeiten und Widersprüchen. Dies erschwert nicht nur die Vermittlung der systemtheoretischen Grundlagen in der Ausbildung sondern auch eine verlässliche theoretische Fundierung des professionellen Handelns von Praktiker:innen. Nach einer grundsätzlichen Diskussion des Theorie-Praxisverhältnisses in der Psychotherapie, soll in diesem Beitrag dargelegt werden, wie eine konstruktivistische Grundhaltung die absichtsvolle und reflektierte Nutzung verschiedener Systemtheorien erlaubt. Dabei werden die soziologische Systemtheorie sensu Luhmann und die Synergetik in Hinblick auf ihr Auflösungsvermögen und die Passung für verschiedene Phänomenbereiche gegenübergestellt und Anforderungen an eine klinische Theorie der systemischen Therapie definiert.
Beyond the acute: pain in long COVID survivors at 1.5 years
Authors: Oguz-Akarsu Emel , Gullu Gizem , Kilic Erhan , Dinç Yasemin , Akdag Gonul , Rehber Cansu , Karli Necdet 
Published: May 2024

Abstract
Objective
Long COVID, characterized by persistent symptoms post-acute COVID-19, remains a subject of intense investigation. This study focuses on pain, a common and notable symptom reported by long COVID patients.

Method
A cohort of 191 individuals, initially diagnosed with mild-to-moderate COVID-19, was followed up 1.5 years later to assess the frequency, clinical characteristics, and factors associated with pain persistence.

Results
Our study revealed that 31.9% of participants experienced at least one persistent pain symptom after 1.5 years. Headache emerged as the most prevalent symptom (29.8%), followed by myalgia (5.8%) and neuropathic pain (4.2%). Factors such as female gender and the presence of neuropathic pain symptom were identified as predictors of long-term headaches. Myalgia, showed associations with headache, arthralgia, and low ferritin levels. Persistent neuropathic pain symptom (4.2%) was linked to older age, female gender, sore throat, and headache.

Conclusion
This study provides insights into the evolution of pain symptoms over time after COVID-19 infection, emphasizing the interconnection between different pain syndromes. This research contributes to understanding the diverse and evolving nature of pain in long COVID survivors, offering valuable insights for targeted interventions and further investigations into the underlying mechanisms of persistent pain.
Escaping the Loop of Unsustainability: Why and How Business Ethics Matters for Earth System Justice
Authors: Schneider Anselm , Murray John 
Published: May 2024

Abstract
Contemporary society operates beyond safe boundaries of the Earth system. Returning to a safe operating space for humanity within Earth system boundaries is a question of justice. The relevance of the economy—and thus of business—for bringing society back to a safe and just operating space highlights the importance of business ethics research for understanding the role of business in Earth system justice. In this commentary, we explore the relevance of business ethics research for understanding the crucial role of business in the dynamics of the Earth system. We do so by integrating the perspectives of business ethics and system-oriented sustainability science on the basis of the theory of metabolic rift, which explains how the dynamics of capitalism result in the destruction of the natural environment. On this basis, we argue that a mutually reinforcing relationship between perpetual economic growth and profit seeking behaviour of business, which we call the loop of unsustainability, continually deepens the metabolic rift and keeps business from effectively contributing to Earth system justice. This perspective allows us to formulate firm-level and system-level preconditions for attaining Earth system justice, and to sketch a research agenda that links business ethics scholarship with questions of Earth system justice.
Naturalised Inferentialism and the Incompleteness Problem
Authors: Reinikainen Jaakko 
Published: May 2024

AbstractThe paper argues that the naturalised version of semantic inferentialism advanced by Jaroslav Peregrin faces a problem which, following Michael Devitt, I call the incompleteness problem. The main issue has to do with how, according to inferentialism, language is connected to the world. My main claim is that Peregrin’s Protagorean account of correctness is in tension with the idea, made also by Robert Brandom, that language is embodied in the world analogically to how physical objects are embodied in games like football. Against this, I show the two are in fact importantly disanalogical. To solve the incompleteness problem, I argue that naturalised inferentialism should learn the central lessons of semantic externalism, namely that the connection between language and the world must be fundamentally external to the mind, or in Peregrin’s case, to the society of normative attitudes.
State of the art in movement around a remote point: a review of remote center of motion in robotics
Authors: Zhang Wuxiang , Wang Zhi , Ma Ke , Liu Fei , Cheng Pengzhi , Ding Xilun 
Published: May 2024

AbstractThe concept of remote center of motion (RCM) is pivotal in a myriad of robotic applications, encompassing areas such as medical robotics, orientation devices, and exoskeletal systems. The efficacy of RCM technology is a determining factor in the success of these robotic domains. This paper offers an exhaustive review of RCM technologies, elaborating on their various methodologies and practical implementations. It delves into the unique characteristics of RCM across different degrees of freedom (DOFs), aiming to distill their fundamental principles. In addition, this paper categorizes RCM approaches into two primary classifications: design based and control based. These are further organized according to their respective DOFs, providing a concise summary of their core methodologies. Building upon the understanding of RCM’s versatile capabilities, this paper then transitions to an in-depth exploration of its applications across diverse robotic fields. Concluding this review, we critically analyze the existing research challenges and issues that are inherently present in both RCM methodologies and their applications. This discussion is intended to serve as a guiding framework for future research endeavors and practical deployments in related areas.
Antibiotics-Induced Intestinal Immunomodulation Attenuates Experimental Autoimmune Neuritis (EAN)
Authors: Sprenger-Svačina Alina , Klein Ines , Svačina Martin K. R. , Bobylev Ilja , Kohle Felix , Schneider Christian , Schweitzer Finja , Piekarek Nadin , Barham Mohammed , Vehreschild Maria J. G. T. , Lehmann Helmar C. , Farowski Fedja 
Published: May 2024

Abstract

Background
The composition of gut microbiota plays a pivotal role in priming the immune system and thus impacts autoimmune diseases. Data on the effects of gut bacteria eradication via systemic antibiotics on immune neuropathies are currently lacking. This study therefore assessed the effects of antibiotics-induced gut microbiota alterations on the severity of experimental autoimmune neuritis (EAN), a rat model of Guillain-Barré Syndrome (GBS). Myelin P0 peptide 180–199 (P0 180–199)-induced EAN severity was compared between adult Lewis rats (12 weeks old) that received drinking water with or without antibiotics (colistin, metronidazole, vancomycin) and healthy rats, beginning antibiotics treatment immediately after immunization (day 0), and continuing treatment for 14 consecutive days. Neuropathy severity was assessed via a modified clinical score, and then related to gut microbiota alterations observed after fecal 16S rRNA gene sequencing at baseline and after EAN induction. Effectors of gut mucosal and endoneurial immunity were assessed via immunostaining. EAN rats showed increased gut mucosal permeability alongside increased mucosal CD8+ T cells compared to healthy controls. Antibiotics treatment alleviated clinical EAN severity and reduced endoneurial T cell infiltration, decreased gut mucosal CD8+ T cells and increased gut bacteria that may be associated with anti-inflammatory mechanisms, like Lactobacillus or Parasutterella. Our findings point out a relation between gut mucosal immunity and the pathogenesis of EAN, and indicate that antibiotics-induced intestinal immunomodulation might be a therapeutic approach to alleviate autoimmunity in immune neuropathies. Further studies are warranted to evaluate the clinical transferability of these findings to patients with GBS.

Graphical Abstract
Sharper vision, steady hands: can robots improve subretinal drug delivery? Systematic review
Authors: Łajczak Paweł Marek , Nawrat Zbigniew 
Published: May 2024

AbstractSubretinal injection (SI) is a novel drug delivery method, directly to retina for treatment of various eye disease. However, manual injection requires surgical experience and precision due to physiological factors. Robots offer solution to this issue, by reducing hand tremor and increased accuracy. This systematic review analyzes current status on robot-assisted SI compared to conventional techniques. Systematic search across 5 databases was conducted to identify studies comparing manual and robot-assisted SI procedures. Extracted data included robotic systems, complications, and success rates. Four studies, including one human trial, two ex vivo porcine eye studies, and one artificial eye model study were included in the synthesis. The findings show early advantages of robot-assisted SI. Compared to traditional interventions, robot procedures result in reduced tremor, what potentially lowers the risk of complications, including retinal tears and reflux. The first in-human randomized trial showed encouraging results, with no significant differences in surgical times or complications between robot-assisted and manual SI. However, major limitation of robot-assisted procedures is longer procedure time. Robot-assisted SI holds promise by offering increased precision and stability, reducing human error and potentially improving clinical outcomes. Challenges include cost, availability, and learning curve. Overall, early stage of robot-assisted SI suggests advantages in precision, complication reduction, and potentially improved drug delivery. Further research in human randomized trials is needed to fully assess its full-scale clinical application.
Problems and related results in algebraic vision and multiview geometry
Authors: Bertolini Marina , Turrini Cristina 
Published: May 2024

AbstractThis article is a survey of results in algebraic vision and multiview geometry. The starting point is the study of projective algebraic varieties which are critical for scene reconstruction. Initially studied for reconstructing static scenes in three-dimensional spaces, these critical loci are later investigated for dynamic and segmented scenes in higher-dimensional projective spaces. The formal analysis of the ideals of critical loci employs Grassmann tensors, introduced as crucial tools for determining these ideals and aiding the reconstruction process away from critical loci. A long-term goal of the authors with other co-authors involves two main aspects: firstly studying properties of Grassmann tensors, as rank, multi-rank and core, along with the varieties that parameterize these tensors; concurrently conducting an analysis of families of critical loci in various scenarios.
Enhancing the Performance of Perovskite Light-Emitting Diodes via Synergistic Effect of Defect Passivation and Dielectric Screening
Authors: Yu Xuanchi , Guo Jia , Mao Yulin , Shan Chengwei , Tian Fengshou , Meng Bingheng , Wang Zhaojin , Zhang Tianqi , Kyaw Aung Ko Ko , Chen Shuming , Sun Xiaowei , Wang Kai , Chen Rui , Xing Guichuan 
Published: May 2024

AbstractMetal halide perovskites, particularly the quasi-two-dimensional perovskite subclass, have exhibited considerable potential for next-generation electroluminescent materials for lighting and display. Nevertheless, the presence of defects within these perovskites has a substantial influence on the emission efficiency and durability of the devices. In this study, we revealed a synergistic passivation mechanism on perovskite films by using a dual-functional compound of potassium bromide. The dual functional potassium bromide on the one hand can passivate the defects of halide vacancies with bromine anions and, on the other hand, can screen the charged defects at the grain boundaries with potassium cations. This approach effectively reduces the probability of carriers quenching resulting from charged defects capture and consequently enhances the radiative recombination efficiency of perovskite thin films, leading to a significant enhancement of photoluminescence quantum yield to near-unity values (95%). Meanwhile, the potassium bromide treatment promoted the growth of homogeneous and smooth film, facilitating the charge carrier injection in the devices. Consequently, the perovskite light-emitting diodes based on this strategy achieve a maximum external quantum efficiency of ~ 21% and maximum luminance of ~ 60,000 cd m−2. This work provides a deeper insight into the passivation mechanism of ionic compound additives in perovskite with the solution method.
Research progress and application of two-dimensional materials for surface-enhanced Raman scattering
Authors: Zhang Weida , Peng Yusi , Lin Chenglong , Xu Meimei , Zhao Shuai , Masaki Tanemura , Yang Yong 
Published: May 2024

AbstractSurface Enhanced Raman Scattering (SERS) is a pivotal detection technology that identifies molecular spectral signals at the single-molecule level. Owing to its sensitivity and non-destructive nature, SERS has found extensive applications in diverse fields such as environmental science, medical diagnosis, food safety, and bioanalysis. In recent years, two-dimensional materials have emerged as one prominent novel SERS-active nanomaterials due to their unique physical and chemical properties. This paper provides a comprehensive review of the enhancement mechanism of SERS, substrate preparation, and its applications in biosensing, environmental detection, and food safety. It delves into the widely accepted basic theory and enhancement mechanism of SERS, along with common methods to boost SERS performance, including doping with other elements, applying stress and strain, forming defects, and amorphous processing. This paper examines the current state of research on two-dimensional(2D) materials and their application in the field of SERS. Additionally, it provides an viewpoints on recent advancements in the use of this technology for virus and cancer detection. Lastly, it discusses the future prospects for the development of SERS technology.
Simulation as a potential tool for successful clinical trial initiation
Authors: Dadiz Rita , Jones Rachel , Guillet Ronnie 
Published: May 2024

Abstract
Conducting clinical trials is often complex and involves many individuals from a variety of services, each with a specific role in ensuring its successful implementation. Although an experienced clinical trialist may anticipate many of the challenges, others may be unexpected and detrimental to the successful completion of a study. We describe the use of simulation during preparation for initiation of a randomized clinical trial of a new preparation of antiseizure medication in neonates with seizures. The process of identification of stakeholders and roles, scenario development, and identification of challenges are described. Lessons learned included the potential benefits of simulation exercises, simulation challenges, and challenges associated with the study itself. We posit that going through the steps of a study, rather than merely reading them from a manual of procedures, will help identify potential barriers, complexities, and contingencies that are not readily apparent and may result in fewer protocol deviations and violations.
Indistinguishable asymptotic pairs and multidimensional Sturmian configurations
Authors: BARBIERI SEBASTIÁN , LABBÉ SÉBASTIEN 
Published: May 2024

AbstractTwo asymptotic configurations on a full
$\mathbb {Z}^d$
-shift are indistinguishable if, for every finite pattern, the associated sets of occurrences in each configuration coincide up to a finitely supported permutation of
$\mathbb {Z}^d$
. We prove that indistinguishable asymptotic pairs satisfying a ‘flip condition’ are characterized by their pattern complexity on finite connected supports. Furthermore, we prove that uniformly recurrent indistinguishable asymptotic pairs satisfying the flip condition are described by codimension-one (dimension of the internal space) cut and project schemes, which symbolically correspond to multidimensional Sturmian configurations. Together, the two results provide a generalization to
$\mathbb {Z}^d$
of the characterization of Sturmian sequences by their factor complexity
$n+1$
. Many open questions are raised by the current work and are listed in the introduction.