bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preoperative risk factors for skeletal muscle mass loss in patients with biliary tract cancer
Authors: Sugiura Ryo , Kuwatani Masaki , Kawakubo Kazumichi , Kishi Kazuma , Yonemura Hiroki , Nozawa Shunichiro , Ohara Masatsugu , Noji Takehiro , Hirano Satoshi , Sakamoto Naoya 
Published: June 2024

AbstractBackgroundEndoscopic retrograde cholangiography (ERC)‐related procedures, usually performed before biliary tract cancer (BTC) surgery, are associated with increased risk for various complications, which can cause sarcopenia. No study has previously elucidated the relationship between preoperative ERC‐related procedures and sarcopenia/skeletal muscle mass loss.MethodsPatients with BTC who underwent radical surgical resection following ERC‐related procedures were included. Skeletal muscle mass was evaluated using the psoas muscle mass index (PMI), which was determined using computed tomography images, and the change in PMI before the initial pre‐ERC and surgery (ΔPMI) was calculated. Risk factors for advanced skeletal muscle mass loss, defined as a large ΔPMI, were evaluated.ResultsThe study cohort included 90 patients with a median age of 72 (interquartile range, 65–75) years. The median PMI pre‐ERC and surgery was 4.40 and 4.15 cm2/m2, respectively (p < .01). The median ΔPMI was −6.2% (interquartile range, −10.9% to 0.5%). By multivariate analysis, post‐ERC pancreatitis and cholangitis before surgery were independent predictive factors for large PMI loss (odds ratio, 4.57 and 3.18, respectively; p = .03 and p = .02, respectively).ConclusionsSkeletal muscle mass decreases preoperatively in most patients with BTC undergoing ERC. Post‐ERC pancreatitis and cholangitis before surgery were independent risk factors for large skeletal muscle mass loss.
Intra‐ and interlaboratory reproducibility evaluation toward international validation status of the AmpFire assay
Authors: Chung Pui Yan Jenny , Dhillon Sharonjit K. , Baraquin Alice , Tkachenka Yuliya , Jacquot Killian , Prétet Jean‐Luc , Broeck Davy Vanden , Arbyn Marc 
Published: June 2024

AbstractTo meet the screening goal of WHO's 90‐70‐90 strategy aimed at eliminating cervical cancer (CC) by 2030, clinical validation of human papillomavirus (HPV) assays is essential to provide accurate and valid results through fulfilling three criteria of the international validation guidelines (IVGs). Previously, the clinical accuracy of the AmpFire® HPV Screening 16/18/HR assay (AmpFire assay) was reported but reproducibility data are lacking. Here, we aim to evaluate the intra‐ and inter‐laboratory reproducibility of the AmpFire assay. The reproducibility of the isothermal AmpFire assay was assessed using 556 cervical cell samples collected from women attending CC screening and biobanked in a Belgian HPV national reference center. This assay detects HPV16, HPV18, and 12 other high‐risk HPV (hrHPV) types (31/33/35/39/45/51/52/56/58/59/66/68) in aggregate. Lower 95% confidence interval bound around the assay's reproducibility should exceed 87%, with κ ≥ 0.50. Additionally, a literature review of the assay's clinical performance was performed. The AmpFire assay showed an excellent intralaboratory (96.4%, 95% CI:94.5–97.8%, κ = 0.920) and interlaboratory (95.3%, 95% CI:93.2–96.9%, κ = 0.897) reproducibility. One study demonstrated noninferior sensitivity of a prototype AmpFire assay targeting 15 hrHPV types (including HPV53) to detect CIN2+. However, clinical specificity became similar to the comparator after removing HPV53 from analyses. The low‐cost and easy‐to‐use AmpFire assay presents excellent reproducibility and—after removing HPV53 from the targeted types—fulfills also clinical accuracy requirements. Inclusion of HPV53, which is not recognized as carcinogenic, comprises clinical specificity of screening assays.
Early‐life and chronic exposure to high‐fat diet alters noradrenergic and glutamatergic neurotransmission in the male rat amygdala and hippocampus under cognitive challenges
Authors: Osorio‐Gómez Daniel , Perez Claudia I. , Salcedo‐Tello Pamela , Hernández‐Matias Arturo , Hernández‐Ramírez Susana , Arroyo Benjamin , Pacheco‐López Gustavo , Gutierrez Ranier , Bermúdez‐Rattoni Federico , Guzmán‐Ramos Kioko ,   OBETEEN Consortium
Published: June 2024

AbstractChildhood obesity increases the risk of health and cognitive disorders in adulthood. Consuming high‐fat diets (HFD) during critical neurodevelopmental periods, like childhood, impairs cognition and memory in humans and animals, affecting the function and connectivity of brain structures related to emotional memory. However, the underlying mechanisms of such phenomena need to be better understood. This study aimed to investigate the neurochemical profile of the amygdala and hippocampus, brain structures involved in emotional memory, during the acquisition of conditioned odor aversion in male rats that consumed a HFD from weaning to adulthood. The rats gained weight, experienced metabolic changes, and reduced insulin sensitivity and glucose tolerance. Rats showed enhanced odor aversion memory, contrary to the expected cognitive impairments. This memory enhancement was accompanied by increased noradrenergic and glutamatergic neurotransmission in the amygdala and hippocampus. Importantly, this upregulation was specific to stimuli exposure, as basal neurotransmitter levels remained unaltered by the HFD. Our results suggest that HFD modifies cognitive function by altering neurochemical signaling, in this case, upregulating neurotransmitter levels rendering a stronger memory trace, demonstrating that metabolic dysfunctions do not only trigger exclusively detrimental plasticity processes but also render enhanced plastic effects depending on the type of information.
Early diet and the risk of coeliac disease. An update 2024 position paper by the ESPGHAN special interest group on coeliac disease
Authors: Szajewska Hania , Shamir Raanan , Auricchio Renata , Chmielewska Anna , Dolinsek Jernej , Kivelä Laura , Koletzko Sibylle , Korponay‐Szabo Ilma R. , Af Segerstad Elin M Hård , Mearin M. Luisa , Meijer‐Boekel Caroline , Konickx Carmen Ribes , Rodriguez‐Herrera Alfonso , Stordal Ketil , Troncone Riccardo , Wessels Margreet 
Published: June 2024

AbstractThis position paper by the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) Special Interest Group on Coeliac Disease (SIG‐CD) presents an update to the 2016 recommendations concerning early diet and the risk of coeliac disease (CD). This update adheres to the policy that mandates reviewing guidelines every 5 years, particularly when new data emerge. The 2024 statements and recommendations are essentially similar to the 2016 recommendations. Breastfeeding, whether any amount, exclusive, or of any duration, does not reduce the risk of developing CD. Introducing gluten into an infant's diet at any time between completed 4 months (≥17 weeks) and 12 months of age does not affect the cumulative incidence of CD, although earlier introduction may lead to earlier seroconversion and CD. In observational studies involving cohorts with a known risk for CD, consuming a high amount of gluten compared to a low amount during weaning and in the subsequent childhood years—specifically the first 2–3 years, and even up to 5 years in some studies—was associated with an increased risk for CD. However, the specific optimal amounts of gluten consumption remain undetermined due to insufficient evidence on safe thresholds, and the impact of restricting gluten in the diet of healthy children of unknown risk for CD is unknown. Thus, any recommendation on the gluten amount is currently unjustifiable for the general population and infants with known HLA risk types. There is no specific guidance on the type of gluten‐containing foods to be introduced at weaning.
Expression of CD28, FAS, PD1, and CTLA4 molecules in the blood of women with triple‐negative breast cancer
Authors: Salgado Marcelo Ramos Tejo , Sobral Denise Viana , Martins Mario R. , Salgado Eduardo Forte M. T. , Salgado Amanda Forte M. T. , Silva Kamylla Ramos da , Soares Fernando Augusto , Torres Leuridan C. 
Published: June 2024

AbstractBackgroundLocally advanced triple‐negative breast cancer (TNBC) represents a public health problem in Brazil. Its standard treatment consists of neoadjuvant chemotherapy (NAC).MethodsThis was a longitudinal study with follow‐up performed between the years 2015 and 2017. Thirty women with locally advanced TNBC submitted to NAC, and 30 healthy were included. Peripheral blood samples were collected before NAC (Pre‐NAC) and after NAC (Post‐NAC).ResultsPatients with TNBC had elevated levels of CD28+ T, FAS+ T, CTLA4+ T, PD1+ T, CD28+CD4+ T, PD1+CD4+ T and CD8+ T and PD1+ CD8+ T cells compared to controls (p < 0.05). Patients with pathological complete response (pCR) had low FAS+ T cells, FAS+CD4+ T cells, and PD1+CD8+ T cells compared to the non‐pCR (p < 0.05). Significant differences were observed in the levels of CD28+ T cells, FAS+ T and PD1+ T, CD4+ T, CD28+CD4+ T, FAS+CD4+ T, PD1+CD4+ T, CD8+ T, and PD1+CD8+ T cells between Pre‐NAC and Post‐NAC groups (p < 0.05).ConclusionAlterations in the circulating FAS+CD4+ T and PD1+CD8+ T cell levels Pre‐NAC are associated with pCR, suggesting potential predictive biomarkers of NAC response in TNBC. The largest changes in the cellular immune response profile Post‐NAC showed that chemotherapy treatment can modulate the immune response and that it is associated with prognosis in TNBC.
Outcomes following cochlear implantation with eluting electrodes: A systematic review
Authors: Fleet Alex , Nikookam Yasmin , Radotra Anshul , Gowrishankar Shravan , Metcalfe Christopher , Muzaffar Jameel , Smith Matthew E. , Monksfield Peter , Bance Manohar 
Published: June 2024

AbstractObjectivesTo establish audiological and other outcomes following cochlear implantation in humans and animals with eluting electrodes.MethodsSystematic review and narrative synthesis. Databases searched (April 2023): MEDLINE, EMBASE, CENTRAL, ClinicalTrials.gov, and Web of Science. Studies reporting outcomes in either humans or animals following cochlear implantation with a drug‐eluting electrode were included. No limits were placed on language or year of publication. Risk of bias assessment was performed on all included studies using either the Brazzelli or Systematic Review Centre for Laboratory animal Experimentation (SYRCLE) assessment tools. The review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) 2020 statement.ResultsSearches identified 146 abstracts and 108 full texts. Of these, 18 studies met the inclusion criteria, reporting outcomes in 523 animals (17 studies) and 24 humans (1 study). Eluting electrodes included dexamethasone (16 studies), aracytine (1 study), nicotinamide adenine dinucleotide (1 study), the growth factors insulin‐like growth factor 1 (IGF1) and hepatocyte growth factor (HGF) (1 study), and neurotrophin‐3 (1 study). All included studies compare outcomes following implantation with an eluting electrode with a control non‐eluting electrode. In the majority of studies, audiological outcomes (e.g., auditory brainstem response threshold) were superior following implantation with an eluting electrode compared with a standard electrode. Most studies which investigated post‐implantation impedance reported lower impedance following implantation with an eluting electrode. The influence of eluting electrodes on other reported outcomes (including post‐implantation cochlear fibrosis and the survival of hair cells and spiral ganglion neurons) was more varied across the included studies.ConclusionsEluting electrodes have shown promise in animal studies in preserving residual hearing following cochlear implantation and in reducing impedance, though data from human studies remain lacking. Further in‐human studies will be required to determine the clinical usefulness of drug‐eluting cochlear implants as a future treatment for sensorineural hearing loss.
Pre‐tactical convection prediction for air traffic flow management using LSTM neural network
Authors: Jardines Aniel , Soler Manuel , García‐Heras Javier , Ponzano Matteo , Raynaud Laure 
Published: June 2024

AbstractThis paper aims to explore machine learning techniques for post‐processing high‐resolution Numerical Weather Prediction (NWP) products for the early detection of convection. Data from the Arome Ensemble Prediction System and satellite observations from the Rapidly Developing Thunderstorm (RDT) product by Météo‐France are used to train a recurrent neural network model to predict areas of total convection and moderate convection. The learning task is formulated as a binary classification problem using a long short‐term memory (LSTM) network architecture. Results from the LSTM model are compared with an object‐based probabilistic approach to forecast convection using metrics such as a receiver operating characteristics (ROC) curve, the Brier score and reliability. Results indicate that the LSTM model performs similarly to the object‐based probabilistic benchmark when classifying moderate convection areas and shows improved skill when classifying areas of total convective. Finally, the LSTM model results are presented within an air traffic management context to showcase the potential use of machine learning models within an operational application.
Water‐avoidance stress aggravates prostatic inflammation in a murine model of chronic prostatitis
Authors: Ni Jianshu , Ren Siyuan , Hu Yi , Ma Dongni , Kuang Yifang , Yoshimura Naoki 
Published: June 2024

AbstractObjectivesTo date, few studies have considered the influence of psychological factors on chronic prostatitis (PRO) models. Here, we aimed to refine a murine PRO model combining chemically induced prostatitis with psychological stress.MethodsA total of 40 mice were randomly divided into four groups: normal control (NC) group, PRO group, water avoidance stress (WAS) group, and PRO + WAS group. Ten mice were assigned to each group: five for cystometrograms (CMGs) and five for von Frey testing and histological analysis. PRO was induced through a prostatic injection of 10% paraformaldehyde. The WAS mice were placed on the middle platform for 1 h per day for 10 consecutive days.ResultsThe results of the von Frey test demonstrated that both WAS and PRO induced bladder hyperalgesia in mice, and the WAS + PRO group showed significant pelvic pain symptoms either. The CMG results suggested that the PRO group, the WAS group, and the PRO + WAS group all exhibited bladder overactivity, presented as a shortened micturition interval and decreased threshold pressure evoking bladder contraction. The symptoms of the PRO group and the PRO + WAS group were more severe than those of the WAS group. The tissue staining results indicated that WAS itself caused only mild prostatic inflammation but could significantly aggravate chemical‐induced prostatic inflammation, as well as the total number of mast cells and proportion of activated mast cells.ConclusionsOur refined murine PRO model could manifest persistent bladder overactivity, pelvic hyperalgesia and prostatic inflammation. WAS could induce mild prostatic inflammation and aggravate primary prostatic inflammation.
Nonprofit talent recruitment: An online experiment on new ways of working and leadership development opportunities
Authors: Geib Nils , Boenigk Silke 
Published: June 2024

AbstractRecruiting talented employees is challenging for nonprofit organizations. This study examines the effects of two possible human resource recruitment practices—offering new ways of working and leadership development opportunities—on the intention of talent to apply for a position at a nonprofit organization. Building on the self‐determination theory, the authors conducted an online survey experiment (n = 389) with aspiring employees in Germany. The results show that, of the offered practices, only “new ways of working” significantly increase individuals' intention to apply. Regarding work sector preferences, nonprofits are in a war for talent, as only 13.6% prefer the nonprofit sector, with most participants (47.8%) preferring to find a job with a for‐profit company or in the public sector (38.6%). As a key nonprofit management implication, recruiters should develop and implement new ways of working to attract talented employees to the nonprofit sector.
Study on mechanical properties and molecular simulation of nano‐SiO2‐modified hybrid fiber reinforced polymer bar under the dry and alkaline environment
Authors: Guan Zhongzhi , Xu Yongli , Zhang Guangzhu , Mao Jize , Wang Hongguang 
Published: June 2024

AbstractFiber reinforced polymer (FRP) bars have received extensive promotion and application in the structural engineering. However, due to the limitations inherent in using single material, FRP reinforced concrete structures often encounter issues, such as brittle failure and inadequate energy dissipation, particularly in complex natural environments and under various loading conditions. In this study, the preparation of nano‐SiO2‐modified carbon/basalt hybrid FRP bars was carried out using the pultrusion‐winding process and ultrasonic treatment. The objective was to investigate the influence of the fiber volume ratio and mass fraction of nano‐SiO2 on the mechanical properties of FRP bars under drying and alkaline conditions. Molecular dynamics simulations were performed to construct interface models between fibers and epoxy resin in order to elucidate the toughening mechanism of nano‐SiO2 and the degradation mechanism in alkaline conditions. The research results show that elevating the substitution rate of carbon fibers and incorporating nano‐SiO2 doping bring about alterations in the brittle fracture characteristics of BFRP bars and enhance the post‐yield performance and interlaminar shear properties of hybrid FRP bars, concurrently mitigating the degradation of mechanical properties induced by exposure to alkaline solutions. MD simulations indicate that the addition of nano‐SiO2 improves the binding rate of hydrogen bonds between BF and epoxy resin, resulting in a higher interfacial energy between BF/epoxy resin compared to CF/epoxy resin. Moreover, nano‐SiO2 effectively mitigates the impact of alkaline solutions on the formation of interfacial hydrogen bonds. The findings of this study serve as a valuable reference for the design and application of FRP reinforced concrete structures.Highlights
Nano‐SiO2 modified B/CFRP bars made via extrusion‐winding & ultrasonic treatment.
Improved mechanical properties and plastic deformation in Nano‐SiO2 modified B/C FRP bars.
Nano‐SiO2 inhibits B/CFRP bars degradation in alkaline solution.
Nano‐SiO2 bind more at BF/epoxy than CF/epoxy interface.
Nano‐SiO2 reduces alkaline solution effect on interfacial H‐bonding.
Self‐compassion defuses the aggression triggered by social exclusion
Authors: Wang Ting , Xiao Qianguo , Wang Han , Hu Yuanyan , Xiang Jinhui 
Published: June 2024

AbstractSocial exclusion is a pervasive phenomenon that can have profound psychological consequences, including increased aggression. Self‐compassion can promote psychological resilience, which helps individuals cope with challenges and may help mitigate the aggression triggered by social exclusion. This study aims to explore the relationship between self‐compassion and aggression in the context of social exclusion from both state and trait perspectives. First, a cross‐sectional study (Study 1) was conducted; the findings revealed that social exclusion is associated with higher levels of aggression, while self‐compassion is linked to lower levels of social exclusion and aggression. Further division of self‐compassion into its constituent components (self‐kindness, mindfulness, and common humanity) revealed additional insights into the specific roles played by these factors. Self‐kindness and mindfulness were found to moderate the relationship between social exclusion and aggression, while common humanity was observed to mediate this relationship. To determine the causal relationships among variables in further detail, an experimental study (Study 2) was designed. This study utilized a recall writing task to induce feelings of social exclusion and employed self‐compassion writing tasks to elicit self‐compassionate responses from participants. The results of this experiment indicated that self‐compassion can significantly reduce the aggression triggered by social exclusion, thus suggesting that self‐compassion may help alleviate the distress caused by individuals' experiences of social exclusion. The findings of this research have important implications for the development of clinical interventions aimed at reducing the adverse effects of social exclusion.
Development of pH response film based on potato starch/polyvinyl alcohol using Kyoho grape skin extract to monitor pork freshness
Authors: Wang Shihui , Zhao Biao , Hao Yanling , He Qixiang 
Published: June 2024

AbstractIn this study, the optimal ratio of starch and polyvinyl alcohol (PVA) was successfully selected by response surface method. The novel packaging films were fabricated by immobilizing Kyoho skin extract (KSE) within starch/PVA composite film by the casting method. The mechanical property, PH sensitivity, and other properties of films with different KSE content (1–5 mL) were studied. The starch/PVA film with 3 mL KSE (SPK3.0 film) showed more uniform structure than the starch/PVA film in microscope. At the same time, the film has strong mechanical properties and low water barrier capacity. Infrared analysis of the film further revealed hydrogen bond interaction between film matrix and KSE. The smart packaging film displayed distinguishable changes of color from purple to green in pH (1–13). Furthermore, the smart films possessed excellent antioxidant. Therefore, the SPK films had the potential application potential in the field of packaging.Highlights
Barrier properties and antioxidant activity were enhanced significantly by the addition of KSE.
The film components are connected by hydrogen bonds so that they have good compatibility.
The functional film shows different colors in the range of pH 1–13.
In Silico Structural Modeling and Analysis of Physicochemical Properties of Antitumoral QS‐13 Peptide and Its Derivatives in Water and Dimethyl Sulfoxide
Authors: Paturel Vivien , Baud Stéphanie , Schneider Christophe , Brassart‐Pasco Sylvie 
Published: June 2024

ABSTRACTThe NC1 domain of the alpha 4 chain of type IV collagen was previously reported to exert anti‐tumor properties in a melanoma model and to inhibit angiogenesis. The minimal active sequence identified to date comprises 13 amino acids: QKISRCQVCVKYS. Unfortunately, this sequence is not soluble in aqueous media and requires prior dissolution in DMSO. The disulfide bridge (DB) that spontaneously forms in solution between two cysteine residues is crucial for its biological activity. The aim of this article was to study the impact of DMSO on the physicochemical properties of the QS‐13 peptide and to replace hydrophobic amino acids to enhance its water solubility. Using bioinformatics (GROMACS, VMD, and ProtParam) and programming (Python and RStudio) software programs, we demonstrated that DMSO could promote the formation of DBs, but it is not strictly necessary. Among the QS‐13 substituted peptides, some were demonstrated to display similar characteristics to the original peptide. Improved water solubility will make the peptide easier to use in biological studies and facilitate its administration for potential therapeutic applications.