bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gn 3, 16-19, ou la « chair-parabole »
Authors: Vivier-Muresan Anne-Sophie 
Published: April 2024

Cette étude souhaite contribuer au renouvellement de nos représentations théologiques sur la création, en déployant notamment l’idée que le monde « fait sens ». Pour ce faire, nous partons de l’analyse des versets difficiles de Gn 3, 16-19, où sont prononcés les jugements divins sur l’homme et la femme après leur consommation du fruit interdit. Le texte semble résister aux différentes exégèses avancées et ne s’éclairerait, selon nous, qu’à partir d’une lecture intertextuelle avec le Nouveau Testament, dans l’horizon de l’avènement du Royaume. Une telle analyse nous mène à énoncer la notion de « chair-parabole », que nous développons à partir d’une définition de la parabole mettant l’accent sur le rapport qu’elle entretient avec l’intertextualité.
Unveiling the role of hypoxia-inducible factor 2alpha in osteoporosis: Implications for bone health
Authors: Wang Ling-Ling , Lu Zhan-Jin , Luo Shun-Kui , Li Yun , Yang Zhe , Lu Hong-Yun 
Published: April 2024

BACKGROUND
Osteoporosis (OP) has become a major public health problem worldwide. Most OP treatments are based on the inhibition of bone resorption, and it is necessary to identify additional treatments aimed at enhancing osteogenesis. In the bone marrow (BM) niche, bone mesenchymal stem cells (BMSCs) are exposed to a hypoxic environment. Recently, a few studies have demonstrated that hypoxia-inducible factor 2alpha (HIF-2α) is involved in BMSC osteogenic differentiation, but the molecular mechanism involved has not been determined.
AIM
To investigate the effect of HIF-2α on the osteogenic and adipogenic differentiation of BMSCs and the hematopoietic function of hematopoietic stem cells (HSCs) in the BM niche on the progression of OP.
METHODS
Mice with BMSC-specific HIF-2α knockout (Prx1-Cre;Hif-2αfl/fl mice) were used for in vivo experiments. Bone quantification was performed on mice of two genotypes with three interventions: Bilateral ovariectomy, semilethal irradiation, and dexamethasone treatment. Moreover, the hematopoietic function of HSCs in the BM niche was compared between the two mouse genotypes. In vitro , the HIF-2α agonist roxadustat and the HIF-2α inhibitor PT2399 were used to investigate the function of HIF-2α in BMSC osteogenic and adipogenic differentiation. Finally, we investigated the effect of HIF-2α on BMSCs via treatment with the mechanistic target of rapamycin (mTOR) agonist MHY1485 and the mTOR inhibitor rapamycin.
RESULTS
The quantitative index determined by microcomputed tomography indicated that the femoral bone density of Prx1-Cre;Hif-2αfl/fl mice was lower than that of Hif-2αfl/fl mice under the three intervention conditions. In vitro , Hif-2αfl/fl mouse BMSCs were cultured and treated with the HIF-2α agonist roxadustat, and after 7 d of BMSC adipogenic differentiation, the oil red O staining intensity and mRNA expression levels of adipogenesis-related genes in BMSCs treated with roxadustat were decreased; in addition, after 14 d of osteogenic differentiation, BMSCs treated with roxadustat exhibited increased expression of osteogenesis-related genes. The opposite effects were shown for mouse BMSCs treated with the HIF-2α inhibitor PT2399. The mTOR inhibitor rapamycin was used to confirm that HIF-2α regulated BMSC osteogenic and adipogenic differentiation by inhibiting the mTOR pathway. Consequently, there was no significant difference in the hematopoietic function of HSCs between Prx1-Cre;Hif-2αfl/fl and Hif-2αfl/fl mice.
CONCLUSION
Our study showed that inhibition of HIF-2α decreases bone mass by inhibiting the osteogenic differentiation and increasing the adipogenic differentiation of BMSCs through inhibition of mTOR signaling in the BM niche.
Klebsiella pneumoniae infections after liver transplantation: Drug resistance and distribution of pathogens, risk factors, and influence on outcomes
Authors: Long Guo , Peng Peng , Peng Wei-Ting , Zhao Jie , Wan Qi-Quan 
Published: April 2024

BACKGROUND
Liver transplantation (LT) is the only curative treatment for end-stage liver disease. However, LT recipients are susceptible to infection, which is the leading cause of early mortality after LT. Klebsiella pneumoniae infections (KPIs) in the bloodstream are common in LT recipients. We hypothesized that KPIs and carbapenem-resistant Klebsiella pneumoniae (CRKP) infections may affect the outcomes of LT recipients.
AIM
To assess KPI incidence, timing, distribution, drug resistance, and risk factors following LT and its association with outcomes.
METHODS
This retrospective study included 406 patients undergoing LT at The Third Xiangya Hospital of Central South University, a tertiary hospital, from January 2015 to January 2023. We investigated the risk factors for KPIs and assessed the impact of KPIs and CRKP infections on the prognosis of LT recipients using logistic regression analysis.
RESULTS
KPI incidence was 7.9% (n = 32), with lung/thoracic cavity the most frequent site of infection; the median time from LT to KPI onset was 7.5 d. Of 44 Klebsiella pneumoniae isolates, 43 (97.7%) and 34 (77.3%) were susceptible to polymyxin B or ceftazidime/avibactam and tigecycline, respectively; > 70% were resistant to piperacillin/ tazobactam, ceftazidime, cefepime, aztreonam, meropenem, and levofloxacin. Female sex [odds ratio (OR) = 2.827, 95% confidence interval (CI): 1.256-6.364; P = 0.012], pre-LT diabetes (OR = 2.794, 95%CI: 1.070-7.294; P = 0.036), day 1 post-LT alanine aminotransferase (ALT) levels ≥ 1500 U/L (OR = 3.645, 95%CI: 1.671-7.950; P = 0.001), and post-LT urethral catheter duration over 4 d (OR = 2.266, 95%CI: 1.016-5.054; P = 0.046) were risk factors for KPI. CRKP infections, but not KPIs, were risk factors for 6-month all-cause mortality post-LT.
CONCLUSION
KPIs occur frequently and rapidly after LT. Risk factors include female sex, pre-LT diabetes, increased post-LT ALT levels, and urethral catheter duration. CRKP infections, and not KPIs, affect mortality.
Relative carcinogenicity of tacrolimus vs mycophenolate after solid organ transplantation and its implications for liver transplant care
Authors: Liu Dorothy , Youssef Mark M , Grace Josephine A , Sinclair Marie 
Published: April 2024

BACKGROUND
De novo malignancy is a leading cause of late morbidity and mortality in liver transplant recipients. Cumulative immunosuppression has been shown to contribute to post-transplant malignancy (PTM) risk. There is emerging evidence on the differential carcinogenic risk profile of individual immunosuppressive drugs, independent of the net effect of immunosuppression. Calcineurin inhibitors such as tacrolimus may promote tumourigenesis, whereas mycophenolic acid (MPA), the active metabolite of mycophenolate mofetil, may limit tumour progression. Liver transplantation (LT) is relatively unique among solid organ transplantation in that immunosuppression monotherapy with either tacrolimus or MPA is often achievable, which makes careful consideration of the risk-benefit profile of these immunosuppression agents particularly relevant for this cohort. However, there is limited clinical data on this subject in both LT and other solid organ transplant recipients.
AIM
To investigate the relative carcinogenicity of tacrolimus and MPA in solid organ transplantation.
METHODS
A literature search was conducted using MEDLINE and Embase databases using the key terms “solid organ transplantation”, “tacrolimus”, “mycophenolic acid”, and “carcinogenicity”, in order to identify relevant articles published in English between 1st January 2002 to 11th August 2022. Related terms, synonyms and explosion of MeSH terms, Boolean operators and truncations were also utilised in the search. Reference lists of retrieved articles were also reviewed to identify any additional articles. Excluding duplicates, abstracts from 1230 records were screened by a single reviewer, whereby 31 records were reviewed in detail. Full-text articles were assessed for eligibility based on pre-specified inclusion and exclusion criteria.
RESULTS
A total of 6 studies were included in this review. All studies were large population registries or cohort studies, which varied in transplant era, type of organ transplanted and immunosuppression protocol used. Overall, there was no clear difference demonstrated between tacrolimus and MPA in de novo PTM risk following solid organ transplantation. Furthermore, no study provided a direct comparison of carcinogenic risk between tacrolimus and MPA monotherapy in solid organ transplantation recipients.
CONCLUSION
The contrasting carcinogenic risk profiles of tacrolimus and MPA demonstrated in previous experimental studies, and its application in solid organ transplantation, is yet to be confirmed in clinical studies. Thus, the optimal choice of immunosuppression drug to use as maintenance monotherapy in LT recipients is not supported by a strong evidence base and remains unclear.
Nutritional and Molecular Studies of Alkaliphilic Tolerant Potential Amylase Producing Lactic Acid Bacteria Isolated from Indigenous Foods and Dumpsites
Authors: Awofe Akinyele Hafiz , Aboomo Okuku Mercy , Ifeanyichukwu Nwokeoma Cheryl , Tunde Aliu Kamoru 
Published: April 2024

Alkaliphilic organisms are important in industries but most of these organisms are obtained from Bacillus species and the like that require special scrutiny before use in fermentation of food related products. Lactic acid bacteria are generally regarded as safe (GRAS) and are therefore readily applied in industrial fermentation with confidence. Due to high demand for the products of alkaliphilic organisms and industrial acceptability of lactic acid bacteria, there is a need to source for GRAS microorganisms that can withstand pH ranges. The aim of this study was to isolate alkaliphilic tolerant lactic acid bacteria from fermented cassava mash, `ogi` and dump site samples with a view to determining their nutritional requirement as well as molecular identity. Lactic acid bacteria were isolated from the samples using standard methods. The isolates were subsequently characterized morphologically, biochemically and molecularly. Effects of different carbon, nitrogen sources, initial temperature and pH as well as metal ions (Na+, Ca2+, Mg2+, Zn2+ and Cu2+) on the growth of the isolates were examined. Data obtained were analyzed using one-way analysis of variance (ANOVA). Results obtained indicate that extracted DNA sequence of A3, A7, A8 and A10 were related to those of Lactobacillus brevis FJ476121.1, Pediococcus acidilactici CP096031.1, Pediococcus pentasaceus AB362605.1 and Pediococcus acidilactici CP053421.1 respectively with the sequences within the GenBank. 1% fructose elicited growth for all the bacteria detected except Lactobacillus brevis and ammonium nitrate was most preferred by all the bacteria detected apart from Pediococcus pentasaceus strain. Lactobacillus brevis FJ476121.1 and Pediococcus acidilactici CP053421.1 were the most alkaliphilic tolerant bacteria detected with OD of 0.285±0.04 and 0.198±0.04 respectively. Different metal ions significantly influenced the growth of isolates in this study. The results in this study indicate potential applicability of the detected bacteria for industrial processes.
Evaluation of Heavy Metals in Roadside Soil of Tumfure Main Market, Gombe State
Authors: Magaji Buhari , Kalu Kalu M. , Edwin Jirina Jennipher 
Published: April 2024

Heavy metal pollution has been a problem of concern in soil ecology in recent decades. This study evaluated the physico-chemical characteristics and heavy metal contents in roadside soil samples of Tumfure main market, Gombe, Nigeria. The soil samples were collected from six different sampling points with a control sample each by handpicking, this was followed by oven-drying, ground to fine grain, and then sieved using a 2 mm mesh sieve. The pH, electrical conductivity and bulk density were carried out on the soil samples, sieve and sedimentation method were used to determine the soil texture. The soil samples were weighed and digested using mixture of HCl and HNO3. The contents (mg/kg) of four metals (cadmium, copper, lead and zinc) were estimated using Atomic Absorption Spectrophotometer (AAS). Among the metals analyzed, the contents of Cd, Cu and Pb were not detected while the content of Zn (23.454 - 36.026) was found to be within the desirable permissible limits by the World Health Organization (WHO) and European Regulatory Standards (EURS) whose prevalence is to be considered non-toxic in unpolluted soils.
PCR Detection of Extended Spectrum β-Lactamase from Some Gram Negative Bacteria of Clinical Source
Authors: Ishola A.D. , Ishola L.T. , Lawal R.T 
Published: April 2024

Beta-lactamase-producing microorganisms present distinct challenges in health care systems around the world as a result of the extensive utilization of broad-spectrum antibiotics. The objective of this research endeavor was to ascertain the antibiotic resistance profile and presence of β-lactamase genes in Gram-negative bacteria that had been previously identified and collected from laboratory work benches at the Department of Microbiology and Parasitology, UCH, located in Ibadan, South-West Nigeria. The Kirby-Bauer disc diffusion method was used to assess antibiotic susceptibility on all the isolates, and the double disc synergy test was used to validate extended spectrum beta-lactamase (ESBL) production phenotypically. The PCR techniques were used to detect β-lactamase genes. The sample distribution of the forty clinical isolates were collected from the work benches and the distribution was: urine (17), blood (9), wound (6), sputum (4), amniotic fluid (3) and tracheal aspirate (1). Klebsiella pneumoniae was the most prevalent organism with 17 isolates ( 42.5% ). Out of the 40 isolates that were obtained, 21 were ESBL producers and the distribution was as follows: Klebsiella pneumoniae (9), Escherichia coli (6), Enterobacter cloacae (2), Enterobacter aerogenes (1), Pseudomonas aeruginosa (1), Acinetobacter baumannii (1) and Hafnia alvei (1). The majority of the clinical isolates showed considerable resistance to antibiotic classes that were tested, with amoxicillin-clavulanate showing the highest resistance rate at 65%. Out of all the ESBL producers, 35.3% had blaTEM, 29.4% had blaCTX-M, 23.5% had blaSHV, and 11.8% had blaCMY. AmpC β-lactamases, Antibiotic resistance, Disc diffusion, Gram-negative bacteria, Polymerase chain reaction.
Software Engineering in Nigeria: Trends and Challenges
Authors: Anas Abdullahi , Labaran Aminu , Bakale Muhammad Abullahi , Aliyu Bashar , Ainu Halimatu Abubakar , Bena AbdulAzeez Abdullahi , Jimada Yusuf Umar 
Published: April 2024

Bringing theory and practice together is aspiration of software engineering education, so that the learner may acquire a deep understanding on basic concepts and principles, along with skills and competences to solve real-world problems. Thus, it is not just an academic concern about teaching relevant topics, but also a task to shape skilled individuals equipped for the industry demand. Moreover, due to the rapid development the software industry is and transnational nature, several challenges are challenging the qualification of software engineers, capable to develop products according to the international standards into markets overseas. Agile software development methods are the generally used and prominent software development methods. Agile methods are simple, easy and deliver software faster than the traditional software development methods. Software development in Nigeria is at developing stage.
The Influence of Location on the Nutritional Composition of the Rind of Watermelon (<i>C. lanatus</i>) in Parts of Selected Geographical Zones in Nigeria
Authors: Akporido Ufuomaroghene Esther , Okoro Israel Oghenevwodoko 
Published: April 2024

Watermelon (C.lanatus)), which was formerly only grown in the Northern part of Nigeria, is now grown in Southern parts also. It is known that weather patterns and soil composition vary as we move from the northern to the southern parts of Nigeria. However, there is little to no data demonstrating how C.lanatus' nutritional composition is influenced by its geographic location. This study therefore sought to assess the nutritional composition of the rind of C.lanatus produced in parts of four states that corresponded to four geopolitical areas of Nigeria. Samples of C. lanatus were gathered from four geopolitical zones of Nigeria which include; North-East, South-West, South-East, and SouthSouth. Fruits were cleaned before the rind was removed, blended, and freeze-drying carried out. The freeze-dried samples were subjected to established methods for the determination of the amino acid profile, vitamins, proximate, and mineral components. The results of the amino acid profile showed that distinct amino acids were present in each zone, with the southwest sample providing the highest quantities and the south-south zone providing the lowest concentrations. The rind of C. lanatus contained calcium, magnesium, potassium, sodium, iron, phosphorus, and manganese in varying amounts, and samples from the south- west and north-east having the highest concentrations of both vitamins and minerals. The results of the proximate composition determination showed that the southwest sample had the highest (p < 0.05) percentage of moisture, protein, and ash when compared to other zones, and that the northeast sample had a higher percentage composition of carbohydrate, ash, and fat when compared to other zones. Thus, the C. lanatus samples' nutritional value were distributed as follows: southwest > northeast > southeast > south-south. According to the findings, C.lanatus rind's nutritional qualities can vary depending on where it is cultivated.
Chemostratigraphy of the Cretaceous Yolde Formation in Yola Sub-Basin, Northern Benue Trough, Ne Nigeria
Authors: Rufai Ahmad Fauziyah , Nuhu K. Samaila , Maigari Abubakar Sadiq , Finthan Boniface 
Published: April 2024

This research aims to determine the chemostratigraphy of the Yolde Formation. The formation has been inadequately studied systematically in the light of chemostratigraphy. The existing works on the formation either lack representativeness in terms of the proxies used or are subjective during their division procedures. From the field studies, five (5) samples of sandstone and shale units of the Yolde Formation were collected. The samples were analyzed for both major and trace elements using an X-ray fluorescence machine. The following geochemical parameters were studied; Al2O3, Al2O3/Fe2O3, KO2/Al2O3, TiO2/Al2O3, CaO, Cr, Rb/Sc, and Zr. From the studies, six (6) chemozones were identified in the Yolde Formation. Transgressive and regressive depositional sequences were observed with a significant sequence boundary of maximum flooding surface which is a time-significant feature. The chemostratigraphic scheme could not only be comparable to the regional sequence stratigraphic scheme but also more objective and higher resolution. This research gives a systematic chemostratigraphic analysis of Yolde Formation, which testifies to the feasibility and potential of the usage of chemostratigraphy for stratigraphic development.
Habitat Utilization and Niche Partitioning in Starling Birds at Federal University Dutse, Nigeria
Authors: Sotayo Falilat Olatoro , Isah Ahmad Garba 
Published: April 2024

The micro habitat or niche which a species occupies at a particular time in an ecosystem may give some clue to niche partitioning with regards to such species in that ecosystem. This study aimed to assess habitat utilization patterns as cue to niche partitioning in starling birds of Federal University Dutse. Point count bird census technique was used to survey starling bird at sixteen (16), randomly selected points, across various habitat types within the study location. All starling birds seen or heard were identified, counted and recorded. The habitat or niche where they were sited was also noted. The R Statistical software, version 3.3 was used for data analysis. The result showed that starling birds species diversity differed significantly by study area points (p < 0.001), habitat types (p < 0.05) and marginally by occurring niche (p = 0.06). Point 13 had the highest species diversity, habitat types consisting farmlands and buildings had the highest species diversity and the highest starling diversity was observed on trees. Starling bird abundance on the other hand, differed significantly across study points (p = 0.05) and marginally across occurring niches (p = 0.06). Starling bird abundance was highest at study area point 5 and on trees.
Determination of Some Heavy Metals in Water and Sediment Samples from Maska Dam, Katsina State, Nigeria
Authors: Aminu Mustapha , Haruna Abbas Umar , Nataala Huzaifa Garba , Aminu Auwal 
Published: April 2024

Water and sediment samples collected from Maska dam in dry and wet seasons were analysed for some heavy metals namely, Cd, Cu, Ni and Zn. After sample digestion, micro-wave Plasma atomic absorption spectroscopy (MPAES) was used to determine the concentrations of the metals. The concentrations were analysed statistically using one way analysis of variance (Anova). The levels of metals in water and sediment were compared with local and international regulatory authorities. From the result of analysis, the concentrations of the metals in (mg/L) were as follows: 0.03±0.01 for Cd, 0.186±0.003 for Cu, 0.19±0.005 for Ni and 0.193±0.003 for Zn, 0.027±0.002 for Cd, 0.057±0.002 for Cu, 0.114±0.002 for Ni and 0.141±0.001 for Zn in water samples in dry and wet seasons. Likewise, the concentration of the metals in sediment in dry and wet seasons were, 0.0196±0.002 for Cd, 0.143±0.003 for Cu, 0.166±0.044 for Ni and 0.766±0.044mg/kg for Zn in dry season. Similarly, 0.019±0.001 for Cd, 0.143±0.004 for Cu, 0.160±0.09 for Ni and 0.451±0.003mg/kg for Zn were obtained in wet season. The concentrations of Cu and Zn were below the permissible limits of WHO/SON while Cd and Ni were above the permissible limit of WHO/SON in water samples. However, the concentrations of all the metals were below the permissible limits of NOAA and USEPA. The result of statistical analysis indicated no significant difference at P greater than 0.05 (P>0.05).