bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Potential of Dutasteride for Treating Multidrug-Resistant Candida auris Infection
Authors: Borgio J. Francis , Almandil Noor B. , Selvaraj Prathas , John J. Sherlin , Alquwaie Rahaf , AlHasani Eman , Alhur Norah F. , Aldahhan Razan , AlJindan Reem , Almohazey Dana , Almofty Sarah , Dhas T. Stalin , AbdulAzeez Sayed 
Published: June 2024

Novel antifungal drugs are urgently needed to treat candidiasis caused by the emerging fungal multidrug-resistant pathogen Candida auris. In this study, the most cost-effective drug repurposing technology was adopted to identify an appropriate option among the 1615 clinically approved drugs with anti-C. auris activity. High-throughput virtual screening of 1,3-beta-glucanosyltransferase inhibitors was conducted, followed by an analysis of the stability of 1,3-beta-glucanosyltransferase drug complexes and 1,3-beta-glucanosyltransferase–dutasteride metabolite interactions and the confirmation of their activity in biofilm formation and planktonic growth. The analysis identified dutasteride, a drug with no prior antifungal indications, as a potential medication for anti-auris activity in seven clinical C. auris isolates from Saudi Arabian patients. Dutasteride was effective at inhibiting biofilm formation by C. auris while also causing a significant reduction in planktonic growth. Dutasteride treatment resulted in disruption of the cell membrane, the lysis of cells, and crushed surfaces on C. auris, and significant (p-value = 0.0057) shrinkage in the length of C. auris was noted at 100,000×. In conclusion, the use of repurposed dutasteride with anti-C. auris potential can enable rapid recovery in patients with difficult-to-treat candidiasis caused by C. auris and reduce the transmission of nosocomial infection.
THE PRACTICE OF INTRODUCTING OF ART-COMUNICATION EXPERIENCE OF BRITISH SCIENTISTS IN THE TRAINING OF FUTURE MUSIC THEACHER IN UKRAINIAN UNIVERSITES
Authors: Rastrygina A. 
Published: June 2024

The article presents the expediency and timeliness of introducing the art-communication experience of British scientists in the training of future teachers of musical art with the aim of acquiring students’ ability to perform artistic and communicative activities in order to restore and support the mental health of Ukrainians in the conditions of war. It has been noted, that the introduction of foreign experience of art-communication interaction in the training of music teachers can become an effective basis for achieving the specified goal. The author’s vision of the appropriateness of the application of the definition of “art- communication” in the context of the development of an updated strategy for the training of music teachers is presented. The prospects of further exploration in the researched direction.
Figurative graphic expressions and the first Western Mediterranean farmers: a new zoomorphic contribution from Southern France
Authors: López-Montalvo Esther , Manen Claire , Guilaine Jean , Baleux François , Convertini Fabien 
Published: June 2024

In Europe, the emergence of the agro-pastoral way of life is accompanied of a novel socio-symbolic system that develops new forms of expression, themes and supports. In this sense, the shape, themes and decorative patterns in ceramics have particularly favoured the characterisation of both regional identities and spheres of influence at different temporal and geographic scales. Among the themes portrayed, the figurative motifs take on special relevance since they also invoke a symbolic sphere that underlies the complex spread of farming from the Near East into Europe. Bearing this in mind, we present the first figurative zoomorphic decoration identified on pottery from the beginning of the Neolithic in Mediterranean France. Although these depictions are well known in Italy and Spain, they were still unheard of in our country. The analysed vase comes from the coastal site of La Corrège (Leucate, Aude), discovered in the 1970s following dredging operations. New radiocarbon dates place this site in the period of full development of the cardial complex in southern France and Mediterranean Spain, between 5300 and 5000 cal. BCE. The three-dimensional reconstruction of the decorated vessel and the microscopic observation of technical gestures, allowed us to virtually replace the motifs on the graphic space provided by the body of the vase, and thus to reproduce the spatial and narrative structure of the decoration. The in-depth analysis of the motifs and spatial patterns allows us to determine the order of the lines and the sequence of execution of the decoration, to interpret this decoration as the representation of a wild animal, probably a wild boar if we consider certain distinctive anatomical features of this species, and to deduce a narrative dimension.
This figurative ornamentation also provides new arguments regarding both the highly diversified means and forms of symbolic expression accompany the Neolithic transition in this area, and the fact that systematic opposition between schematic graphic expression and naturalist expression does not seem to be relevant. In this context, the characterization of the diversity of the graphic expressions of the first farmers’ communities is an important challenge for future research. The study of graphic traditions and their large-scale distribution can thus provide new arguments for the analysis of the spatial and temporal dynamics of Mediterranean Neolithisation, while at the same time promoting our understanding of the symbolic system of the first farming societies, as the driving force of their identity and social
cohesion.
CRECIMIENTO Y ACUMULACIÓN DE NO3- EN LECHUGA HIDROPÓNICA CON RELACIONES NITRATO/AMONIO EN DOS ESTACIONES DE CULTIVO
Authors: Lara-Izaguirre Ana Y. , Rojas-Velázquez Angel N. , Romero-Méndez Mauricio J. , Ramírez-Tobías Hugo M. , Cruz-Crespo Elia , Alcalá-Jáuregui Jorge A. , Catarina Loredo-Ostí Catarina 
Published: June 2024

La lechuga (Lactuca sativa L.) es una hortaliza de hoja que en México genera un importante ingreso económico; sin embargo, los altos niveles de nitratos (NO3-) pueden ocasionar problemas de salud, ya que generan compuestos carcinogénicos. Una alternativa para disminuir el NO3- en hojas es sustituyéndolo por amonio (NH4+), lo que podría beneficiar la salud humana reduciendo la ingesta de NO3-. El objetivo del presente estudio fue evaluar el crecimiento y acumulación de NO3- en lechuga con diferentes relaciones de NO3-/NH4+ en la solución nutritiva en dos estaciones de cultivo. Las lechugas se cultivaron en un sistema hidropónico de raíz flotante. El diseño experimental fue completamente al azar en arreglo factorial 4 × 2, cuatro relaciones de NO3-/NH4+ (100/0, 80/20, 65/35 y 50/50) y dos estaciones de cultivo (verano y otoño), con un total de 8 tratamientos. Las variables evaluadas fueron peso seco de raíz (PSR), de hojas (PSH) y total (PST), área foliar (AF) y concentración de NO3- en peciolo. No se encontraron diferencias significativas entre estaciones para PSH, PST y AF. En otoño el PSR aumentó 11 % en comparación con el de verano. En verano el contenido de NO3- en peciolos aumentó 55 % comparado con el de otoño. La relación 100/0 aumentó 25 % el PSH, PST y AF, y 15 % más de NO3- en peciolo. Durante el verano, utilizando una relación 100/0 se presentó un aumento de 4 % en el PSH, PST y AF. Al usar NH4+ en las relaciones 65/35 y 50/50 se redujo 25 % el crecimiento y 15 % la acumulación de NO3- en peciolo. En la estación de verano la aplicación de 100/0 en plantas de lechuga aumentó el crecimiento. En la estación de verano el contenido de NO3- en peciolo aumentó el doble.
Enhancement-mode Ga2O3 FETs with an unintentionally doped (001) β-Ga2O3 channel layer grown by metal-organic chemical vapor deposition
Authors: Li Botong , Chen Tiwei , Zhang Li , Zhang Xiaodong , Zeng Chunhong , Hu Yu , Huang Zijing , Xu Kun , Tang Wenbo , Shi Wenhua , Cai Yong , Zen Zhongming , Zhang Baoshun 
Published: June 2024

Abstract
High-quality unintentionally doped (UID) (001) β-Ga2O3 homoepitaxial films were grown on native substrates through metalorganic CVD. The surface parallel grooves were repaired under low temperature and pressure conditions, reaching the surface roughness of 2.22 nm and the high electron mobility of 74.6 cm2/Vs. Enhancement-mode MOSFETs were fabricated on the UID β-Ga2O3 film, showing a positive turn-on threshold gate voltage of 4.2 V and a breakdown voltage of 673 V. These results can serve as a reference for (001)-oriented lateral Ga2O3 power transistors and may contribute to the development of Ga2O3 power devices.
Eﬀect of orthodontic adhesives modiﬁed with antibacterial nanoparticles on bond strength: literature review
Authors: Almokaddam H. , Tuturov N. S. , Katbeh I. , Saleh A. , Ibrahim I. 
Published: June 2024

RELEVANCE. With the advent of nanotechnology, new dental products are being created with the addition of various nanoparticles to improve the quality of the material, as well as increase their durability and antibacterial therapy. Recently, nanoparticles of silver, calcium hydroxyapatite, calcium dioxide, magnesium, cinnamon and vanillin are included in orthodontic adhesives to prevent enamel demineralization during ﬁxed appliance treatment. However, the strength of ﬁxation of the bracket system to the tooth enamel plays an important role in resisting orthodontic and mechanical stress in the oral cavity to achieve precise control of tooth movement.AIM. The purpose of this study is to provide an analytical review of laboratory studies on the shear bond strength of orthodontic adhesives modiﬁed with antibacterial nanoparticles.MATERIALS AND METHODS. The eLibrary, PubMed and Google Scholar databases were queried for scientiﬁc articles published from 2019 to 2024 using the keywords: nanoparticles, orthodontics, bond strength, orthodontic adhesive, nanoadhesive. Thus, this article included 13 in vitro studies on the topic of shear adhesion strength of nanoadhesives, the remaining 40 scientiﬁc articles were devoted to the study of methods of using nanotechnologies in the orthodontic clinic, the properties of various nanoparticles and the problems of demineralization of dental tissue during the correction of dentoalveolar anomalies, their prevention.CONCLUSION. Based on this analysis, it was found that most laboratory studies of orthodontic adhesives containing low concentrations of nanoparticles demonstrated positive antimicrobial potential while maintaining acceptable adhesive bond strength. However, further studies are needed in clinical settings, taking into account humidity and temperature changes in the oral cavity, to achieve the best mechanical performance and antibacterial eﬀectiveness against bioﬁlm-forming pathogens during orthodontic therapy.
Terapia de Estimulação Cerebral Profunda para Transtornos Psiquiátricos Resistentes ao Tratamento
Authors: Aurélio Salete Martens , Hoth Núbia de Amorim Costa , Savariego Bárbara de Oliveira Baptista , Paiva Átila Castro , Dias Aguinaldo Pereira , Sousa Lucas Lisboa de Liz , Chaves Fabiola Gondim Medeiros , Corrêa Isabelle de Miranda , Bezerra Leonardo Sobral Torres , Pinheiro Rayane Batista , Rocha Eduardo Henrique Resende , Araújo Neto Antônio Carlos da Silva , Moraes Amanda Tollini de 
Published: June 2024

Introdução: A Terapia de Estimulação Cerebral Profunda (DBS) é uma intervenção neuromodulatória que tem mostrado potencial significativo no tratamento de transtornos psiquiátricos resistentes a tratamentos convencionais. Objetivos: Avaliar a redução dos sintomas em pacientes com transtornos psiquiátricos resistentes. Metodologia: Para a coleta de dados, foram utilizados os bancos de dados: Scientific Electronic Library Online (SCIELO), PubMed e Literatura Latino-Americana do Caribe em Ciências da Saúde (LILACS). Diversos tipos de publicações, como artigos científicos, monografias e revistas, foram consultados para obter informações relevantes sobre o tema. Resultados e Discussões: Os resultados da Terapia de Estimulação Cerebral Profunda (DBS) para transtornos psiquiátricos resistentes ao tratamento demonstraram uma redução significativa dos sintomas em uma proporção substancial de pacientes. Observou-se uma melhora clínica tanto na depressão maior quanto no transtorno obsessivo-compulsivo, indicando o potencial terapêutico da DBS nessas condições. Além disso, os efeitos adversos foram geralmente toleráveis, destacando a segurança relativa deste procedimento. Esses achados sugerem que a DBS pode ser uma opção valiosa para pacientes que não respondem a tratamentos convencionais, embora sejam necessárias mais pesquisas para entender completamente seus mecanismos de ação e otimizar sua aplicação clínica. Conclusão: A Terapia de Estimulação Cerebral Profunda (DBS) mostra-se uma abordagem promissora para o tratamento de transtornos psiquiátricos resistentes, como depressão maior e transtorno obsessivo-compulsivo. Os resultados indicam uma redução significativa dos sintomas em muitos pacientes, destacando a DBS como uma alternativa viável quando os tratamentos convencionais falham. No entanto, a eficácia e a segurança a longo prazo requerem mais investigação. A DBS representa um avanço significativo na Psiquiatria Intervencionista, oferecendo esperança para pacientes com condições severas e refratárias.
Evolución del gobierno abierto y el acceso a la información pública en el estado de Sonora en los años 2021 y 2022
Authors: Morales Tostado Maria del Carmen , Ramírez Villaescusa Rafael , González Beltrones Adria Velia , Herrera Márquez Fernando Antonio 
Published: June 2024

El gobierno abierto, la transparencia y el derecho de acceso a la información, constituyen el centro neurálgico de un buen gobierno. Las estrategias del gobierno abierto se construyen día a día considerando aspectos económicos, sociales, políticos y técnicos.
En esta investigación se eligió el enfoque cualitativo, con alcance descriptivo y explicativo, se recopiló información para elaborar el marco jurídico y se evaluó al Estado de Sonora[i]. El objetivo de este trabajo es analizar los antecedentes, evolución y los resultados de gobierno abierto en el Estado de Sonora en el ejercicio 2021, incluyendo la transparencia y acceso a la información pública.
Dentro de los resultados se conoció que el Índice de Percepción de la Corrupción que determina Transparency International. México se ubica en el lugar 124 de 180 países, en los años 2020 y 2021, con una puntuación de 31 puntos, donde los puntos van de 100 que denota ausencia de corrupción a 0 que revela mucha corrupción.
También, se encontró que el Índice de Gobierno Abierto (IGA), que determina Métrica de gobierno abierto, con el apoyo del Instituto Nacional de Transparencia y el Centro de Investigación y Docencia Económicas en 2021, en México el IGA es de 0.48, donde 1 es un gobierno transparente y abierto a la participación ciudadana y 0 de un gobierno sin apertura. El Estado de Sonora, obtiene 0.51 y en comparación con el ÍGA de México que es de 0.48, el Estado de Sonora se encuentra por arriba de esa puntuación con 0.51.
Sailing or Stumbling: How Do Adult Learners Navigate the Realm of Online Maltese Language Learning?
Authors: Żammit Jacqueline 
Published: June 2024

Due to the COVID-19 epidemic, there has been a necessary transition to online learning. This study aimed to ascertain the distinct factors that contribute to the preference for online learning among a cohort of 42 adult learners who are studying Maltese as a second language. Data was collected through semi-structured interviews that included open-ended questions, enabling participants to express their viewpoints. The responses underwent thematic analysis, which involved using NVivo software to examine trends and classify the data into appropriate topics. The participants provided diverse justifications for their inclination towards online learning. Many participants valued the flexible feature of online learning since it enabled them to acquire knowledge at their preferred pace without experiencing any pressure to hurry. Some individuals appreciated the chance to review recorded sessions, as it enhanced their comprehension of the topic. Several participants emphasised the advantage of being able to acquire knowledge from any location, which resulted in saving commuting time and the ability to learn in a pleasant setting. Additionally, some individuals noted that online learning allowed them to access a wide range of online resources and digital tools, thereby improving their proficiency in digital literacy. Nevertheless, the study also identified obstacles such as technological glitches, absence of in-person communication, and struggles with maintaining motivation. Notwithstanding these difficulties, most of the participants saw online learning as an advantageous substitute, particularly when in-person academic activities were suspended. The study provides ideas for enhancing the online learning experience, considering the distinct preferences and obstacles highlighted by the participants.
CLASSY. IX. The Chemical Evolution of the Ne, S, Cl, and Ar Elements
Authors: Arellano-Córdova Karla Z. , Berg Danielle A. , Mingozzi Matilde , James Bethan L. , Rogers Noah S. J. , Skillman Evan D. , Cullen Fergus , Alexander Ryan K. , Amorín Ricardo O. , Chisholm John , Hayes Matthew , Heckman Timothy , Hernandez Svea , Kumari Nimisha , Leitherer Claus , Martin Crystal L. , Maseda Michael , Nanayakkara Themiya , Parker Kaelee , Ravindranath Swara , Strom Allison L. , Vincenzo Fiorenzo , Wofford Aida 
Published: June 2024

Abstract
To study the chemical evolution across cosmic epochs, we investigate Ne, S, Cl, and Ar abundance patterns in the Cosmic Origins Spectrograph Legacy Archive Spectroscopic SurveY (CLASSY). CLASSY comprises local star-forming galaxies (SFGs; 0.02 < z < 0.18) with enhanced star formation rates, making them strong analogues to high-z SFGs. With direct measurements of electron temperature, we derive accurate ionic abundances for all elements and assess ionization correction factors (ICFs) to account for unseen ions and derive total abundances. We find Ne/O, S/O, Cl/O, and Ar/O exhibit constant trends with gas-phase metallicity for 12+log(O/H) < 8.5 but significant correlation for Ne/O and Ar/O with metallicity for 12+log(O/H) > 8.5, likely due to ICFs. Thus, the applicability of the ICFs to integrated spectra of galaxies could bias results, underestimating true abundance ratios. Using CLASSY as a local reference, we assess the evolution of Ne/O, S/O, and Ar/O in galaxies at z > 3, finding no cosmic evolution of Ne/O, while the lack of direct abundance determinations for S/O and Ar/O can bias the interpretation of the evolution of these elements. We determine the fundamental metallicity relationship (FMR) for CLASSY and compare to the high-redshift FMR, finding no evolution. Finally, we perform the first mass–neon relationship analysis across cosmic epochs, finding a slight evolution to high Ne at later epochs. The robust abundance patterns of CLASSY galaxies and their broad range of physical properties provide essential benchmarks for interpreting the chemical enrichment of the early galaxies observed with the JWST.
Phase-dependent Spectral Shape Changes in the Ultraluminous X-Ray Pulsar NGC 5907 ULX1
Authors: Miura Daiki , Kobayashi Shogo B. , Yamaguchi Hiroya 
Published: June 2024

Abstract
The discovery of coherent pulsations from several ultraluminous X-ray pulsars (ULXPs) has provided direct evidence of a supercritical accretion flow. However, the geometrical structure of such an accretion flow onto the central neutron star remains poorly understood. NGC 5907 ULX1 is one of the most luminous ULXPs, with a luminosity exceeding 1041 erg s−1. Here we present a broadband X-ray study of this ULXP using the data from simultaneous observations with XMM-Newton and NuSTAR conducted in 2014 July. The phase-resolved spectra are well reproduced by a model consisting of a multicolor disk blackbody emission with a temperature gradient of p = 0.5 (T ∝ r
−p
) and a power law with an exponential cutoff. The disk component is phase-invariant and has an innermost temperature of ∼ 0.3 keV. Its normalization suggests a relatively low inclination angle of the disk, in contrast to the previous claims in other literature. The power-law component, attributed to the emission from the accretion flow inside the magnetosphere of the neutron star, indicates phase-dependent spectral shape changes; the spectrum is slightly harder in the pre-peak phase than in the post-peak phase. This implies that the magnetosphere has an asymmetric geometry around the magnetic axis and that hotter regions close to the magnetic pole become visible before the pulse peak.
The Distance to the S147 Supernova Remnant
Authors: Kochanek C. S. , Raymond John C. , Caldwell Nelson 
Published: June 2024

Abstract
In the absence of a parallax distance to a pulsar or a surviving binary in a supernova remnant (SNR), distances to Galactic SNRs are generally very uncertain. However, by combining Gaia data with wide-field, multifiber echelle spectroscopy, it is now possible to obtain accurate distances to many SNRs with limited extinction by searching for the appearance of high-velocity Ca ii or Na i absorption lines in hot stars as a function of distance. We demonstrate this for the SNR S147 using the spectra of 259 luminous blue stars. We obtain a median distance of 1.37 kpc (1.30–1.47 kpc at 90% confidence), which is consistent with the median parallax distance to the pulsar of 1.46 kpc (1.12–2.10 kpc at 90% confidence) but with significantly smaller uncertainties. Our distance is also consistent with the distance to the candidate unbound binary companion in this SNR, HD 37424 at a photogeometric distance of 1.45 kpc (1.40–1.50 kpc at 1σ). The presence of high-velocity absorption lines is correlated with the Hα/O [iii] emission-line flux of the SNR but not with the radio flux.
Changing Look of the Optical Spectrum of the MeV Blazar PKS 0446+112 (4FGL J0449.1+1121)
Authors: Paiano Simona , Falomo Renato , Treves Aldo , Scarpa Riccardo , Sbarufatti Boris 
Published: June 2024

Abstract
Following the high activity of the γ-ray Fermi source 4FGL J0449.1+1121 (PKS 0446+112), possibly associated with a IceCube neutrino event IC-240105A, we obtained optical spectroscopy with the Gran Telescopio Canarias of the counterpart. We detect a clear emission line at 3830 Å identified as Lyα that confirms the redshift of source at z = 2.153. Comparing with previous spectroscopy, we find an increase of the continuum by a factor ∼10, and a significant decrease of the C iv 1550 emission line flux by a factor ∼5. This produces a dramatic drop of the equivalent width from ∼20 to 0.8 Å, which is suggestive of a very high jet activity. The full width half maximum of the emission lines are midway (1000–2000 km s −1) between those typical of the broad and narrow regions of quasars. Based on this, the source classification is intermediate between flat spectrum radio quasar and BL Lac object.