bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ensuring the Continuity of Care of Cardiorespiratory Diseases at Home
Authors: Tzavaras A. , Botsivaly M. , Koutsourakis K. , Spyropoulos B. 
Published: February 2010

Summary
Objectives: A significant portion of care related to cardiorespiratory diseases is provided at home, usually but not exclusively, after the discharge of a patient from hospital. It is the purpose of the present study to present the technical means which we have developed, in order to support the adaptation of the continuity of care of cardiorespiratory diseases at home.
Methods: We have developed an integrated system that includes: first, a prototype laptop-based portable monitoring system that comprises low-cost commercially available components, which enable the periodical or continuous monitoring of vital signs at home; second, software supporting medical decision-making related to tachycardia and ventricular fibrillation, as well as fuzzy-rules-based software supporting home-ventilation optimization; third, a typical continuity of care record (CCR) adapted to support also the creation of a homecare plan; and finally, a prototype ontology, based upon the HL7 clinical document architecture (CDA), serving as basis for the development of semantically annotated web services that allow for the exchange and retrieval of homecare information.
Results: The flexible design and the adaptable data-exchange mechanism of the developed system result in a useful and standard-compliant tool, for cardiorespiratory disease-related homecare.
Conclusions: The ongoing laboratory testing of the system shows that it is able to contribute to an effective and low-cost package solution, supporting patient supervision and treatment. Furthermore, semantic web technologies prove to be the perfect solution for both the conceptualization of a continuity of care data exchange procedure and for the integration of the structured medical data.
Exotropic Drift and Ocular Alignment After Surgical Correction for Intermittent Exotropia
Authors: Leow Po-Lin , Ko Simon T. C. , Wu Patrick K. W. , Chan Clement W. N. 
Published: February 2010

Purpose:
To evaluate changes in the angle of deviation over time and compare the motor success rate with different initial postoperative deviation in patients undergoing surgical correction for intermittent exotropia.

Methods:
Forty-eight patients aged between 1 and 10 years who underwent bilateral lateral rectus recession for intermittent exotropia were retrospectively evaluated. Preoperative and postoperative ocular deviations at 1 week, 1 month, and 6 months were analyzed. Full surgical correction was attempted in all patients. Motor success was defined as ocular deviation within 10 prism diopters of orthophoria at 6 months postoperatively.

Results:

The follow-up period ranged from 6 months to 3 years. Although most patients had exotropic drift, this drift was greater in patients with initial esotropia (86.7%) and orthophoria (70.0%) compared to patients with exotropia (26.1%). Motor success was achieved in 29 (60.4%) patients. There was no statistical difference between ocular alignment at 1 week postoperatively and final motor success (
P
= .782). There was good correlation between ocular alignment at 1 week and 6 months postoperatively (ρ = 0.585,
P
< .001). Age and preoperative deviation were not found to be associated with motor success.

Conclusions:
The success rate appears to be unaffected by initial ocular alignment, suggesting that deliberate initial overcorrection may be unnecessary. Future studies are warranted to evaluate the long-term stability of this alignment.

[J Pediatr Ophthalmol Strabismus 2010;47:12–16.]
High Measured Intraocular Pressure in Children With Recessive Congenital Hereditary Endothelial Dystrophy
Authors: Khan Arif O. , Al-Shehah Abdulmajid , Ghadhfan Faisal E. 
Published: February 2010

Purpose:
To report the phenomenon of high measured intraocular pressure in recessive congenital hereditary endothelial dystrophy.

Methods:
A case series was retrospectively reviewed.

Results:
Five infants with significant congenital corneal haze had increased measured intraocular pressure that remained high despite drug treatment and surgery to decrease intraocular pressure. The clinical diagnosis of recessive congenital hereditary endothelial dystrophy without glaucoma was made based on the absence of buphthalmos, a distinct pattern of mosaic corneal haze with significant corneal thickness, and absence of cupping in healthy-appearing optic nerve heads.

Conclusion:
Intraocular pressure can be falsely elevated in some children with recessive congenital hereditary endothelial dystrophy, leading to confusion with congenital glaucoma.

[J Pediatr Ophthalmol Strabismus 2010;47:29–33.]
Corneal Collagen Cross-linking With Riboflavin and UVA Irradiation in Pellucid Marginal Degeneration
Authors: Spadea Leopoldo 
Published: February 2010

PURPOSE:
To report the results of corneal collagen cross-linking (CXL) with riboflavin and ultraviolet A irradiation in a patient affected by pellucid marginal degeneration (PMD).

METHODS:
A 43-year-old man with bilateral PMD underwent CXL in the left eye. The treatment was performed in standard fashion with the exception of slightly inferior decentration of the 9-mm–diameter irradiated area preserving an untreated surface area 1 mm from the limbus.

RESULTS:
Epithelial regrowth was complete after 4 days' use of a bandage soft contact lens. No side effects or damage to the limbal region were observed during re-epithelialization or during follow-up. Corrected distance visual acuity improved from 20/200 to 20/63 at 3 months and was stable through the 12-month interval. Keratometric astigmatism showed a 1.40-diopter (D) reduction and the power of ectasia apex decreased from 82.00 D to 78.00 D.

CONCLUSIONS:

Corneal collagen CXL was a safe tool in the management of PMD, improving some parameters in advanced stages of the disease. [
J Refract Surg
. 2010;26:375–377.]
Transpupillary Thermotherapy of Subfoveal Choroidal Neovascularization Secondary to Pathologic Myopia
Authors: Nabawi Khaled S. , Shaarawi Ashraf S. 
Published: February 2010

BACKGROUND AND OBJECTIVE:
To assess the safety and effectiveness of transpupillary thermotherapy treatment of subfoveal choroidal neovascular membrane secondary to pathologic myopia.

PATIENTS AND METHODS:
Seventy-four patients (74 eyes) with pathologic myopia underwent transpupillary thermotherapy treatment using a 3.0-mm spot size, 1-minute duration, and 520-mW power delivered through a contact lens. Clinical evaluation included measurement of best-corrected Snellen visual acuity, slit-lamp biomicroscopy, fundus color photography, and fluorescein angiography.

RESULTS:
Sixty-four eyes (86%) received one treatment session. Six eyes (8%) improved 0.1 logarithm of the minimum angle of resolution (LogMAR) visual acuity post-treatment, 10 eyes (13.5%) lost more than 0.2 LogMAR acuity, and another 10 eyes (13.5%) lost 0.1 LogMAR acuity. The remaining 48 eyes (65%) had unchanged visual acuity after the last follow-up visit.

CONCLUSION:
Transpupillary thermotherapy preserves vision in patients with choroidal neovascular membrane associated with pathologic myopia. Younger patients and eyes with higher refractive error are more likely to benefit from treatment.

[Ophthalmic Surg Lasers Imaging 2010;41:12–17.]
Effects of Intravitreal Erythropoietin Therapy for Patients With Chronic and Progressive Diabetic Macular Edema
Authors: Li Weiye , Sinclair Stephen H. , Xu Guo-Tong 
Published: February 2010

BACKGROUND AND OBJECTIVE:
To determine the effects of intravitreal injections of erythropoietin in eyes with severe, chronic diabetic macular edema, 5 eyes of 5 patients underwent injections of rHuEPO alpha (EPO).

PATIENTS AND METHODS:
All eyes had progressive vision loss and persistent or worsening edema with prior multi-modal treatment. EPO (5U/50 µL) was injected intravitreally every 6 weeks for three doses and followed for an additional 6 weeks with complete ocular examinations, fluorescein angiography, optical coherence tomography (OCT), and central field acuity perimetry.

RESULTS:
Visual acuity of all patients was subjectively improved by 3 or more lines in 3 eyes and 1 line in 2 eyes. Visual acuity improved to a larger extent than anatomic improvement by OCT. Clearing of hard exudates but only minor improvement in leakage on fluorescein angiography was observed. Improvement in vision occurred within 1 week after the first injection and was maintained until the end point of the current case series (at 18 weeks after the first injection).

CONCLUSION:
This case series seems to show a short-term positive response to EPO for a specific group of patients with chronic diabetic macular edema who were unresponsive to currently available therapies.

[Ophthalmic Surg Lasers Imaging 2010;41:18–25.]
Boundary Detection Errors on Optical Coherence Tomography Images in Patients With Diabetic Retinopathy
Authors: Schneider Miklos , Seres Andras , Borgulya Gabor , Nemeth Janos 
Published: February 2010

BACKGROUND AND OBJECTIVE:
To study the incidence of boundary detection errors produced by optical coherence tomography measurements in patients with diabetic retinopathy.

PATIENTS AND METHODS:
One hundred sixteen eyes with diabetic retinopathy of 64 consecutive patients with diabetes mellitus were included in this retrospective study. The StratusOCT instrument (Carl Zeiss Meditec, Dublin, CA) with the macular thickness map protocol was used for the examinations. After data acquisition, each scan was analyzed using the retinal thickness (single eye) protocol to evaluate whether there was any misdetection of the retinal boundaries.

RESULTS:
Boundary detection errors were found in 35.3% of eyes. The majority of artifacts were those caused by hard exudates (41.5%), followed by cystoid macular edema (31.7%) and proliferation (17.0%).

CONCLUSION:
Occurrence of artifacts with optical coherence tomography measurements in cases of diabetic retinopathy is not a rare phenomenon and verification of quantitative measurements is strongly recommended.

[Ophthalmic Surg Lasers Imaging 2010;41:54–59.]
Comparison of Torsional and Microburst Longitudinal Phacoemulsification: A Prospective, Randomized, Masked Clinical Trial
Authors: Vasavada Abhay R. , Raj Shetal M. , Patel Udayan , Vasavada Vaishali , Vasavada Viraj 
Published: February 2010

BACKGROUND AND OBJECTIVE:
To compare intraoperative performance and postoperative outcome of three phacoemulsification technologies in patients undergoing microcoaxial phacoemulsification through 2.2-mm corneal incisions.

PATIENTS AND METHODS:
The prospective, randomized, single-masked study included 360 eyes randomly assigned to torsional (Infiniti Vision System; Alcon Laboratories, Fort Worth, TX), microburst with longitudinal (Infiniti), or microburst with longitudinal (Legacy Everest, Alcon Laboratories) ultrasound. Assessments included surgical clock time, fluid volume, and intraoperative complications, central corneal thickness on day 1 and months 1 and 3 postoperatively, and endothelial cell density at 3 months postoperatively. Comparisons among groups were conducted.

RESULTS:

Torsional ultrasound required significantly less surgical clock time and fluid volume than the other groups. There were no intraoperative complications. Change in central corneal thickness and endothelial cell loss was significantly lower in the torsional ultrasound group at all postoperative visits (
P
< .001, Kruskal–Wallis test) compared to microburst longitudinal ultrasound modalities.

CONCLUSION:
Torsional ultrasound demonstrated quantitatively superior intraoperative performance and showed less increase in corneal thickness and less endothelial cell loss compared to microburst longitudinal ultrasound.

[Ophthalmic Surg Lasers Imaging 2010;41:109–114.]
Assessment and Comparison of Anterior Chamber Dimensions Using Various Imaging Techniques
Authors: Dinc Umut Asli , Oncel Banu , Gorgun Ebru , Yenerel Melda Nursal , Alimgil Levent 
Published: February 2010

BACKGROUND AND OBJECTIVE:
To assess and compare the horizontal dimensions of the anterior chamber by different anterior segment imaging techniques.

PATIENTS AND METHODS:
Eighty eyes of 40 patients without any ocular disease or previous ocular surgery were recruited and three consecutive measurements of internal anterior chamber diameter and white-to-white distance (WTW) parameters were determined.

RESULTS:

Mean internal anterior chamber diameter was 11.80 ± 0.39, 11.56 ± 0.47, and 11.61 ± 0.58 mm with Visante-OCT, SL-OCT, and Pentacam, respectively. Mean WTW distance was 11.87 ± 0.35 and 11.65 ± 0.32 mm by IOLMaster and OrbscanIIz, respectively. There was no significant difference between Visante-OCT and Pentacam, IOLMaster, and OrbscanIIz (
P
= .125, .918, and .314). However, detection of mean internal anterior chamber diameter was significantly greater by Visante-OCT than SL-OCT (
P
= .026). All devices displayed a high intrasession repeatability (repeated measured ANOVA,
P
> .05).

CONCLUSION:
Internal anterior chamber diameter measurements using Visante-OCT, SL-OCT, and Pentacam, and WTW measurements using IOLMaster and OrbscanIIz were easy to handle and demonstrated good repeatability. Although similar results of horizontal anterior chamber diameter were determined by Visante-OCT, Pentacam, IOLMaster, and OrbscanIIz, the inter-device differences should be considered during clinical practice.

[Ophthalmic Surg Lasers Imaging 2010;41:115–122.]
Real-Time Ultrasound Elastographic Imaging of Ocular and Periocular Tissues: A Feasibility Study
Authors: Detorakis Efstathios T. , Drakonaki Eleni E. , Tsilimbaris Miltiadis K. , Pallikaris Ioannis G. , Giarmenitis Spiridon 
Published: February 2010

BACKGROUND AND OBJECTIVE:
This study examines the value of ultrasound elastography for the examination of ocular and periocular structures.

SUBJECTS AND METHODS:
Five patients, aged 22 to 75 years, who each had one blind eye were included. Patients underwent ultrasound elastography of their blind eye and periocular tissues using a 7–13 MHz probe. Strain grayscale and color-coded elastographic maps were recorded. In the former, a quantitative assessment of signal intensity (corresponding to elastic properties) for specific anatomical structures was performed.

RESULTS:
Anterior vitreous displayed intermediate elasticity, whereas posterior vitreous displayed low elasticity. Medial and lateral rectus muscle elasticity was higher in primary position than in adduction or abduction.

CONCLUSION:
The pattern of elastic imaging in the vitreous cavity could be attributed to posterior vitreous detachment, whereas that of medial and lateral rectus muscles may be related to the level of muscle fiber strain.

[Ophthalmic Surg Lasers Imaging 2010;41:135–141.]
Identification of Small‐Molecule Scaffolds for P450 Inhibitors
Authors: von Kries Jens P. , Warrier Thulasi , Podust Larissa M. 
Published: February 2010

AbstractMycobacterium tuberculosiscytochrome P450 enzymes (CYP) attract ongoing interest for their pharmacological development potential, driving direct screening efforts against potential CYP targets with the ultimate goal of developing potent CYP‐specific inhibitors and/or molecular probes to addressM. tuberculosisbiology. The property of CYP enzymes to shift the ferric heme Fe Soret band in response to ligand binding provides the basis for an experimental platform for high‐throughput screening (HTS) of compound libraries to select chemotypes with high binding affinities to the target. Promising compounds can be evaluated in in vitro assays or in vivo disease models and further characterized by x‐ray crystallography, leading to optimization strategies to assist drug design. Protocols are provided for compound library screening, analysis of inhibitory potential, and co‐crystallization with the target CYP, as well as expression and purification of soluble CYP enzymes.Curr. Protoc. Microbiol. 16:17.4.1‐17.4.25. © 2010 by John Wiley & Sons, Inc.
Ultrafast Imaging and the Phase Problem for Inelastic X‐Ray Scattering
Authors: Abbamonte Peter , Wong Gerard C. L. , Cahill David G. , Reed James P. , Coridan Robert H. , Schmidt Nathan W. , Lai Ghee Hwee , Joe Young Il , Casa Diego 
Published: February 2010

AbstractA new method for imaging ultrafast dynamics in condensed matter using inelastic X‐ray scattering (IXS) is described. Using the concepts of causality and irreversibility a general solution to the inverse scattering problem (or “phase problem”) for IXS is illustrated, which enables direct imaging of dynamics of the electron density with resolutions of ∼1 attosecond (10−18 s) in time and <1 Å in space. This method is not just Fourier transformation of the IXS data, but a means to impose causality on the data and reconstruct the charge propagator. The method can also be applied to inelastic electron or neutron scattering. A general outline of phenomena that can and cannot be studied with this technique and an outlook for the future is provided.
Endogenous neurosteroid synthesis modulates seizure frequency
Authors: Lawrence Courtney , Martin Brandon Scott , Sun Chengsan , Williamson John , Kapur Jaideep 
Published: February 2010

AbstractInhibitory neurosteroids, molecules generated in glia from circulating steroid hormones and de novo from cholesterol, keep seizures in check in epileptic animals. They can enhance inhibitory transmission mediated by gamma‐aminobutyric acid receptors and have anticonvulsant action. ANN NEUROL 2010;67:689–693
Efficient Evaluation of Ranking Procedures when the Number of Units is Large, with Application to SNP Identification
Authors: Louis Thomas A. , Ruczinski Ingo 
Published: February 2010

AbstractSimulation‐based assessment is a popular and frequently necessary approach for evaluating statistical procedures. Sometimes overlooked is the ability to take advantage of underlying mathematical relations and we focus on this aspect. We show how to take advantage of large‐sample theory when conducting a simulation using the analysis of genomic data as a motivating example. The approach uses convergence results to provide an approximation to smaller‐sample results, results that are available only by simulation. We consider evaluating and comparing various ranking‐based methods for identifying the most highly associated SNPs in a genome‐wide association study, derive integral equation representations of the pre‐posterior distribution of percentiles produced by three ranking methods, and provide examples comparing performance. These results are of interest in their own right and set the framework for a more extensive set of comparisons.
Robust and classical PLS regression compared
Authors: Liebmann Bettina , Filzmoser Peter , Varmuza Kurt 
Published: February 2010

AbstractClassical PLS regression is a well‐established technique in multivariate data analysis. Since classical PLS is known to be severely affected by the presence of outliers in the data or deviations from normality, several PLS regression methods with robust behavior towards data contamination have been proposed. We compare the performance of the classical SIMPLS approach with the partial robust M regression (PRM). Both methods are applied to three different data sets including outliers intentionally created. A simulated data set with known true model parameters allows insight in the modeling performance with increasing data contamination. QSPR data are modified with a cluster of outlying observations. A third data set from near infrared (NIR) spectroscopy is likely to include noise and experimental errors already in the original variables, and is further contaminated with outliers. To provide a sound comparison of the considered methods we apply repeated double cross validation. This validation procedure judiciously optimizes the model complexity (number of PLS components) and estimates the models' prediction performance based on test‐set predicted errors. All studied robust regression models outperform the classical PLS models when outlying observations are present in the data. For uncontaminated data, the prediction performances of both the classical and the robust models are in the same range. Copyright © 2010 John Wiley & Sons, Ltd.
Unaliasing of aliased line component frequencies
Authors: Moghtaderi Azadeh , Takahara Glen , Thomson David J. 
Published: February 2010

AbstractThis paper is concerned with undoing aliasing effects, which arise from discretely sampling a continuous‐time stochastic process. Such effects are manifested in the frequency‐domain relationships between the sampled and original processes. The authors describe a general technique to undo aliasing effects, given two processes, one being a time‐delayed version of the other. The technique is based on the observations that certain phase information between the two processes is unaffected by sampling, is completely determined by the (known) time delay, and contains sufficient information to undo aliasing effects. The authors illustrate their technique with a simulation example. The theoretical model is motivated by the helioseismological problem of determining modes of solar pressure waves. The authors apply their technique to solar radio data, and conclude that certain low‐frequency modes known in the helioseismology literature are likely the result of aliasing effects. The Canadian Journal of Statistics 38: 116–135; 2010 © 2010 Statistical Society of Canada
Immunohistochemical surrogate markers of breast cancer molecular classes predicts response to neoadjuvant chemotherapy
Authors: Bhargava Rohit , Beriwal Sushil , Dabbs David J. , Ozbek Umut , Soran Atilla , Johnson Ronald R. , Brufsky Adam M. , Lembersky Barry C. , Ahrendt Gretchen M. 
Published: February 2010

AbstractBACKGROUND:Complete pathologic response to neoadjuvant chemotherapy (NACT) is predominantly seen in “ERBB2” and “basal‐like” tumors using expression profiling. We hypothesize that a similar response could be predicted using semiquantitative immunohistochemistry for estrogen receptors (ER), progesterone receptors (PR), and human epidermal growth factor receptor 2 (HER2).METHODS:ER, PR, and HER2 were used to classify 359 tumors treated with NACT into 6 groups: luminal A (strong ER+, HER2 negative), luminal B (weak to moderate ER+, HER2 negative), triple negative (negative for ER, PR, and HER2), ERBB2 (negative for ER and PR, but HER2+), luminal A‐HER2 hybrid (strong ER+ and HER2+), and luminal B‐HER2 hybrid (weak to moderate ER+ and HER2+). Complete pathologic response was defined as absence of invasive carcinoma in the breast and regional lymph nodes.RESULTS:Thirteen percent (48 of 359) demonstrated complete pathologic response. The highest rate of complete pathologic response was seen in ERBB2 (33%; 19 of 57) and triple negative (30%; 24 of 79) tumor classes. Among the ER+ “molecular” group, the highest rate of complete pathologic response was seen among luminal B‐HER2 hybrid tumors, 8% (2 of 24). Remainder of ER+ tumors demonstrated a very low rate of complete pathologic response, 1.5% (3 of 198). The 5‐year survival for patients achieving complete pathologic response was 96% compared with 75% in patients that failed to achieve complete pathologic response. The overall survival was worse in the ER‐negative group (ERBB2 and triple negative) compared with the ER‐positive group.CONCLUSIONS:We confirm the recently defined “triple negative paradox,” or rather “hormone receptor negative paradox,” that despite the best response to NACT, ERBB2 and triple negative tumors show the worst overall survival because of higher relapse among those with residual disease. Cancer 2010. © 2010 American Cancer Society.