bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bayesian process optimization using failure amplification method
Authors: Yu I‐Tang , Joseph V. Roshan 
Published: May 2010

AbstractThis work is motivated by a problem of optimizing printed circuit board manufacturing using design of experiments. The data are binary, which poses challenges in model fitting and optimization. We use the idea of failure amplification method to increase the information supplied by the data and then use a Bayesian approach for model fitting. The Bayesian approach is implemented using Gaussian process models on a latent variable representation. It is demonstrated that the failure amplification method coupled with a Bayesian approach is highly suitable for optimizing a process with binary data. Copyright © 2010 John Wiley & Sons, Ltd.
People with intellectual disability as neighbours: Towards understanding the mundane aspects of social integration
Authors: van Alphen Laura M. , Dijker Anton J. M. , van den Borne Bart H. W. , Curfs Leopold M. G. 
Published: May 2010

AbstractAlthough people with intellectual disabilities (ID) are increasingly expected to relocate from traditional institutional care to ‘regular’ neighbourhood housing facilities and socially integrate in these neighbourhoods, little is known about how they are perceived and appreciated as neighbours. This paper reports on interviews carried out with 30 neighbours without ID who were neighbours of small‐scale care facilities for people with ID. Interviews addressed the neighbours' everyday experiences of neighbouring in general, and neighbouring people with ID in particular. Neighbouring, for these informants, called for a fine balance between friendliness without over‐involvement. While they were generally positive about their interactions with their neighbours with ID, it emerged that the formal nature of the care facility and the interaction style of some of the neighbours with ID often contravened informants' assumptions about neighbouring. Informants expressed concern about a possible lack of appropriate distance, reciprocity and accountability among their neighbours with ID. The nature of the care facility, with paid staff, often group activities, formal means of achieving the everyday small tasks which neighbours sometimes do for each other, and a high turnover of residents, all undermined the possibility of a typical neighbourly relationship. In conclusion, we suggest that integration of people with ID into everyday neighbouring relationships raises complex challenges for care organizations that need to find a balance between supporting the needs of people with ID they care for, adequate support and mediation for other neighbours when necessary, and all the while avoid becoming overly involved in neighbouring as a formal partner. Copyright © 2010 John Wiley & Sons, Ltd.
Interaction of hIAPP with Model Raft Membranes and Pancreatic β‐Cells: Cytotoxicity of hIAPP Oligomers
Authors: Weise Katrin , Radovan Diana , Gohlke Andrea , Opitz Norbert , Winter Roland 
Published: May 2010

AbstractType II diabetes mellitus (T2DM) is associated with β‐cell failure, which correlates with the formation of pancreatic islet amyloid deposits. The human islet amyloid polypeptide (hIAPP) is the major component of islet amyloid and undergoes structural changes followed by self‐association and pathological tissue deposition during aggregation in T2DM. There is clear evidence that the aggregation process is accelerated in the presence of particular lipid membranes. Whereas hIAPP aggregation has been extensively studied in homogeneous model membrane systems, especially negatively charged lipid bilayers, information on the interaction of hIAPP with heterogeneous model raft membranes has been missing until now. In the present study, we focus on the principles of aggregation and amyloid formation of hIAPP in the presence of model raft membranes. Time‐lapse tapping mode AFM and confocal fluorescence microscopy experiments followed membrane permeabilization and localization of hIAPP in the raft membrane. Together with the ThT and WST‐1 assay, the data revealed elevated cytotoxicity of hIAPP oligomers on INS‐1E cells.
Randomized comparison of endothelial progenitor cells capture stent versus cobalt‐chromium stent for treatment of ST‐elevation myocardial infarction. Six‐month clinical, angiographic, and IVUS follow‐up
Authors: Bystroň Marian , Červinka Pavel , Špaček Radim , Kvašňák Martin , Jakabčin Jozef , Červinková Michaela , Kala Petr , Widimský Petr 
Published: May 2010

AbstractPurpose: The aim of this trial was to assess the feasibility and safety of endothelial progenitor cells capture (EPC) stent in the treatment of acute ST‐elevation myocardial infarction (STEMI) when compared with cobalt‐chromium stents (CoCr). Methods: Between July 2006 and May 2008, 100 patients with single vessel disease undergoing primary PCI for STEMI were randomly assigned to receive either EPC stent (N = 50) or CoCr stent (N = 50). High‐pressure stent implantation was carried out in both groups. Dual antiplatelet treatment was administered for 30 days in both groups. All patients underwent 6‐month clinical, angiographic, and IVUS follow‐up. Results: The rate of major adverse cardiovascular events (MACEs) at 30 days was comparable in both groups. At 6‐month follow‐up, the rates of MACEs and TLR in the EPC stent group when compared with CoCr stent were 24% vs.10%; P = 0.06 and 14% vs. 4%; P = 0.08, respectively. There were three cases (6%) of stent thrombosis (ST) in the EPC stent group versus none in CoCr group. Conclusion: The use of EPC capture stents in the setting of STEMI is feasible and safe in terms of 30‐days outcome. However, at the 6‐month follow‐up, we found a trend of higher rates of MACE and TLR in the EPC stent capture group compared to CoCr stents. The study does not support the use of EPC capture stents with short duration dual antiplatelet therapy in patients with STEMI. Future randomized studies with large sample sizes would be necessary to demonstrate the safety of such approach. © 2010 Wiley‐Liss, Inc.
Aortic coarctation by cardiovascular CT angiography
Authors: Gopal Ambarish , Loewinger Lee , Budoff Matthew J. 
Published: May 2010

AbstractThe patient is a 12‐year‐old boy who underwent prospectively gated step‐and‐shoot chest CT (computed tomographic) angiography with a 64‐multislice CT scanner (64‐MSCT) for a preliminary diagnosis of coarctation of aorta. The data was acquired in a manner to significantly minimize radiation to the patient, including use of 80 kVp (rather than 120 kVp, much more commonly employed in cardiac CT), low mA (120 mA, rather than typical 400 mA), and prospective acquisition using a VCT 64 detector scanner (General Electric, Milwaukee, WI) (Figs. 1 and 2). Total radiation dose was 0.9 mSv, despite imaging from sternal notch to liver. Findings included dilated ascending aorta (43 mm diameter) and a total coarctation of descending aorta with very well‐developed collaterals. The left internal mammary artery and right internal mammary artery were noted to be very large (7 mm diameter). © 2010 Wiley‐Liss, Inc.
A randomized comparison of TR band and radistop hemostatic compression devices after transradial coronary intervention
Authors: Rathore Sudhir , Stables Rodney H. , Pauriah Maheshwar , Hakeem Abdul , Mills Joseph D. , Palmer Nick D. , Perry Raphael A. , Morris John L. 
Published: May 2010

AbstractBackground: The transradial route for coronary intervention has proven to be safe, effective, and widely applicable in different clinical situations. Several compressive hemostatic devices have been introduced that have shown to be safe and are effective in achieving hemostasis. Methods: Seven hundred ninety patients were randomly assigned to receive either TR band or Radistop hemostatic compression devices after transradial coronary procedure. The outcome measures were patient tolerance of the device, local vascular complications, and the time taken to achieve hemostasis. Results: The mean age was 62.88 years, and 74.2% of the patients were men. Patient age, height, weight, wrist circumference, body mass index, male sex, hypertension, diabetes, hypercholesterolemia, and smoking incidences were similar in both groups. There were significantly more patients reporting no discomfort in the TR band group compared to the Radistop group (77% vs. 61%; P = 0.0001). Patients in the Radistop group reported significantly more pain across all categories of severity and three patients in the Radistop group were crossed over to TR band because of severe discomfort. Oozing and ecchymosis were seen in about 16% of the patients. Local small hematoma and large hematoma were seen in 5.4% and 2.2% patients respectively, and similar in both groups. Radial artery occlusion at the time of discharge was seen in 9.2% of the patients though only 6.8% showed persistent occlusion at the time of follow‐up. The time taken to achieve hemostasis was significantly longer in the TR Band group (5.32 ± 2.29 vs. 4.83 ± 2.23 hr; P = 0.004). There was significantly higher incidence of radial artery occlusion in patients with smaller wrist circumference, the patients who experienced radial artery spasm during the procedure, and patients with no heparin administration during the procedure. Conclusions: We have shown in a randomized comparison of Radistop and TR band that both devices are safe and effective as hemostatic compression devices following transradial procedures. However, more patients felt discomfort with the Radistop device and the time taken to achieve hemostasis was longer with TR band. © 2010 Wiley‐Liss, Inc.
Histopathology of aspirated thrombus and its association with ST‐segment recovery in patients undergoing primary percutaneous coronary intervention with routine thrombus aspiration
Authors: Verouden Niels J.W. , Kramer Miranda C. , Li XiaoFei , Meuwissen Martijn , Koch Karel T. , Henriques José P.S. , Baan Jan , Vis Marije M. , Piek Jan J. , van der Wal Allard C. , Tijssen Jan G.P. , de Winter Robbert J. 
Published: May 2010

AbstractBackground: In patients with ST‐segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI) with thrombus aspiration, the histopathology of aspirated thrombus was previously related to long‐term mortality. In this study, we sought to investigate the association between histopathology of aspirated thrombus and ST‐segment recovery, a marker of microvascular dysfunction, immediately at the end of the PCI procedure. Methods: We included 892 STEMI patients who underwent primary PCI with routine thrombus aspiration and for whom combined data on histopathology of aspirated thrombus and ST‐segment recovery were available. Patients were categorized according to histopathology of aspirated thrombus: fresh only (<1 day), older (>1 day), or no material aspirated. ST‐segment recovery was defined as incomplete if <50%. Results: Incomplete ST‐segment recovery occurred in 134 of 363 patients (37%) with fresh thrombus, in 104 of 238 patients (44%) with older thrombus, and in 142 of 291 patients (49%) with no material. Unadjusted odds ratios for incomplete ST‐segment recovery of patients with older thrombus and no material, when compared with patients with fresh thrombus, were 1.33 (95% CI, 0.95–1.85; P = 0.097) and 1.63 (95% CI 1.19–2.23; P = 0.002), respectively. Both associations were unchanged after multivariable adjustment for clinical predictors of ST‐segment recovery. ST‐segment recovery was a strong predictor of long‐term mortality, independent of the histopathology of aspirated thrombus. Conclusions: This study shows that ST‐segment recovery immediately at the end of the PCI procedure was a significant prognosticator, independent of the histopathology of aspirated thrombus. We found that the histopathology of aspirated thrombus (fresh, older, no material) was associated with ST‐segment recovery in STEMI patients undergoing primary PCI with thrombus aspiration. © 2010 Wiley‐Liss, Inc.
Entrapped coronary angioplasty stent balloon due to nondeflation: Percutaneous retrieval by a simple technique
Authors: Girish M.P. , Gupta Mohit D. , Tyagi Sanjay 
Published: May 2010

AbstractComplication due to hardware failure may happen even in the most straightforward interventional procedures. We report an unusual complication of nondeflation of coronary stent balloon entrapped within the coronary tree. The nondeflated balloon was retrieved percutaneously by a simple technique. © 2010 Wiley‐Liss, Inc.
Series of transcatheter valve‐in‐valve implantations in high‐risk patients with degenerated bioprostheses in aortic and mitral position
Authors: Seiffert Moritz , Franzen Olaf , Conradi Lenard , Baldus Stephan , Schirmer Johannes , Meinertz Thomas , Reichenspurner Hermann , Treede Hendrik 
Published: May 2010

AbstractObjectives: We report our experience with transcatheter valve‐in‐valve implantations in patients with degenerated bioprostheses in aortic and mitral position. Background: Xenograft degeneration is a potential problem after biological valve replacement. Reoperation remains the gold standard with very good short‐ and long‐term results. In selected patients not suitable for surgery however, interventional techniques for valve implantation and repair may be valuable alternative treatment options with regard to the good results of transcatheter valve implantation for native aortic valve stenosis. Methods: Five patients presented with significant xenograft degeneration 15.4 ± 5.2 years after aortic (n = 4) and mitral (n = 1) valve replacement. Mean patient age was 82.0 ± 6.5 years and predicted operative mortality was 55.8% ± 18.9% (logistic EuroSCORE). Transcatheter valve‐in‐valve implantation was performed successfully through a transapical access in all patients. A 23‐mm Edwards Sapien valve was deployed into the degenerated valve prosthesis. Results: Mean transvalvular gradients were reduced from 31.2 ± 17.4 to 19.0 ± 12.4 mm Hg in aortic and from 9 to 3 mm Hg in mitral position without significant regurgitation in any of these patients. Two patients died within 30 days due to low cardiac output and acute hemorrhage, respectively, one of whom presented with a EuroSCORE of 88.9%. Conclusions: With growing need for reoperative valve replacement in elderly patients with disproportional operative risks, transcatheter valve‐in‐valve implantation in aortic and mitral position offers an alternative treatment option. Although valve function after transcatheter implantation was good in all patients, two high risk patients died in the postoperative period due to their significant comorbidities, underscoring the bail‐out character of this procedure. © 2010 Wiley‐Liss, Inc.
Mechanical embolectomy for large vessel ischemic strokes: A cardiologist's experience
Authors: Abelson Mark , Roos Johan 
Published: May 2010

AbstractIntroduction: Large vessel acute ischemic stroke has a poor outcome. Intravenous (IV) thrombolysis is often contra‐indicated and if given, usually ineffective. Mechanical embolectomy is an option in these patients and may be performed by an interventional cardiologist experienced in carotid interventions. Method: Consecutive stroke patients were assessed by the stroke physician and, if eligible, referred for possible mechanical embolectomy using the Merci retriever. All procedures were done by a single cardiologist. Patient information, procedural characteristics and clinical outcomes at 90 days were collected by retrospective chart review. Results: A total of 22 patients were referred for emergency cerebral angiography with 17 undergoing mechanical embolectomy. The mean National Institute of Health Stroke Scale (NIHSS) score was 20.1 and the mean stroke duration was 284 min. Recanalization was successful in 15 (88%) patients. Ten patients (59%) had a good outcome (modified Rankin Score ≤2 at 90 days) and four died (mortality 23%). Three patients had significant intra‐cerebral hemorrhage. There were no other major adverse events. Conclusions: For patients with large vessel occlusion strokes where IV thrombolysis was either contra‐indicated or had failed, mechanical embolectomy performed by an interventional cardiologist had a high recanalization rate with an acceptable clinical outcome and safety profile. © 2010 Wiley‐Liss, Inc.
Unravelling the Reaction Mechanism for the Fast Photocyclisation of 2‐Benzoylpyridine in Aqueous Solvent by Time‐Resolved Spectroscopy and Density Functional Theory Calculations
Authors: Du Yong , Xue Jiadan , Li Ming‐De , Guan Xiangguo , McCamant David W. , Phillips David Lee 
Published: May 2010

AbstractA combined femtosecond transient absorption (fs‐TA) and nanosecond time‐resolved resonance Raman (ns‐TR3) spectroscopic investigation of the photoreaction of 2‐benzoylpyridine (2‐BPy) in acetonitrile and neutral, basic and acidic aqueous solvents is reported. fs‐TA results showed that the nπ* triplet 2‐BPy is the precursor of the photocyclisation reaction in neutral and basic aqueous solvents. The cis triplet biradical and the cis singlet zwitterionic species produced during the photocyclisation reaction were initially characterised by ns‐TR3 spectroscopy. In addition, a new species was uniquely observed in basic aqueous solvent after the decay of the cis singlet zwitterionic species and this new species was tentatively assigned to the photocyclised radical anion. The ground‐state conformation of 2‐BPy in acidic aqueous solvent is the pyridine nitrogen‐protonated 2‐BPy cation (2‐BPy‐NH+) rather than the neutral form of 2‐BPy. After laser photolysis, the singlet excited state (S1) of 2‐BPy‐NH+ is generated and evolves through excited‐state proton transfer (ESPT) and efficient intersystem crossing (ISC) processes to the triplet exited state (T1) of the carbonyl oxygen‐protonated 2‐BPy cation (2‐BPy‐OH+) and then photocyclises with the lone pair of the nitrogen atom in the heterocyclic ring. Cyclisation reactions take place both in neutral/basic and acidic aqueous solvents, but the photocyclisation mechanisms in these different aqueous solvents are very different. This is likely due to the different conformation of the precursor and the influence of hydrogen‐bonding of the solvent on the reactions.
Cyclic Carbonate Synthesis Catalysed by Bimetallic Aluminium–Salen Complexes
Authors: Clegg William , Harrington Ross W. , North Michael , Pasquale Riccardo 
Published: May 2010

AbstractThe development of bimetallic aluminium–salen complexes [{Al(salen)}2O] as catalysts for the synthesis of cyclic carbonates (including the commercially important ethylene and propylene carbonates) from a wide range of terminal epoxides in the presence of tetrabutylammonium bromide as a cocatalyst is reported. The bimetallic structure of one complex was confirmed by X‐ray crystallography. The bimetallic complexes displayed exceptionally high catalytic activity and in the presence of tetrabutylammonium bromide could catalyse cyclic carbonate synthesis at atmospheric pressure and room temperature. Catalyst‐reuse experiments demonstrated that one bimetallic complex was stable for over 60 reactions, though the tetrabutylammonium bromide decomposed in situ by a retro‐Menschutkin reaction to form tributylamine and had to be regularly replaced. The mild reaction conditions allowed a full analysis of the reaction kinetics to be carried out and this showed that the reaction was first order in aluminium complex concentration, first order in epoxide concentration, first order in carbon dioxide concentration (except when used in excess) and unexpectedly second order in tetrabutylammonium bromide concentration. Further kinetic experiments demonstrated that the tributylamine formed in situ was involved in the catalysis and that addition of butyl bromide to reconvert the tributylamine into tetrabutylammonium bromide resulted in inhibition of the reaction. The reaction kinetics also indicated that no kinetic resolution of racemic epoxides was possible with this class of catalysts, even when the catalyst was derived from a chiral salen ligand. However, it was shown that if enantiomerically pure styrene oxide was used as substrate, then enantiomerically pure styrene carbonate was formed. On the basis of the kinetic and other experimental data, a catalytic cycle that explains why the bimetallic complexes display such high catalytic activity has been developed.
Optically Degradable Dendrons for Temporary Adhesion of Proteins to DNA
Authors: Kostiainen Mauri A. , Kotimaa Juha , Laukkanen Marja‐Leena , Pavan Giovanni M. 
Published: May 2010

AbstractExperimental studies and molecular dynamics modeling demonstrate that multivalent dendrons can be used to temporarily glue proteins and DNA together with high affinity. We describe N‐maleimide‐cored polyamine dendrons that can be conjugated with free cysteine residues on protein surfaces through 1,4‐conjugate addition to give one‐to‐one protein–polymer conjugates. We used a genetically engineered cysteine mutant of class II hydrophobin (HFBI) and a single‐chain Fragment variable (scFv) antibody as model proteins for the conjugation reactions. The binding affinity of the protein–dendron conjugates towards DNA was experimentally assessed by using the ethidium bromide displacement assay. The binding was found to depend on the generation of the dendron, with the second generation having a stronger affinity than the first generation. Thermodynamic parameters of the binding were obtained from molecular dynamics modeling, which showed that the high binding affinity for each system is almost completely driven by a strong favorable binding enthalpy that is opposed by unfavorable binding entropy. A short exposure to UV (λ≈350 nm) can cleave the photolabile o‐nitrobenzyl‐linked binding ligands from the surface of the dendron, which results in loss of the multivalent binding interactions and triggers the release of the DNA and protein. The timescale of the release is very rapid and the binding partners can be efficiently released after 3 min of UV exposure.
Comparison of Thiophene–Pyrrole Oligomers with Oligothiophenes: A Joint Experimental and Theoretical Investigation of Their Structural and Spectroscopic Properties
Authors: Oliva María Moreno , Pappenfus Ted M. , Melby Jacob H. , Schwaderer Kathryn M. , Johnson Jared C. , McGee Kari A. , da Silva Filho Demetrio A. , Bredas Jean‐Luc , Casado Juan , López Navarrete Juan T. 
Published: May 2010

AbstractWe have prepared a new series of mixed thiophene–pyrrole oligomers to investigate the electronic benefits arising from the combination of these two heterocycles. The oligomers are functionalized with several hexyl and aryl groups to improve both processability and chemical robustness. An analysis of their spectroscopic (absorption and emission), photophysical, electrochemical, solid state, and vibrational properties is performed in combination with quantum‐chemical calculations. This analysis provides relevant information regarding the use of these materials as organic semiconductors. The balance between the high aromatic character of pyrrole and the moderate aromaticity of thiophene allows us to address the impact of the coupling of these heterocycles in conjugated systems. The data are interpreted on the basis of the aromaticity, molecular conformations, ground and excited electronic state structures, frontier orbital topologies and energies, oxidative states, and quinoidal versus aromatic competition.