bluuebunny/crossref_metadata_2025_split huggingface dataset:
Choice, Rating, and Ranking: Framing Effects with Different Response Modes
Authors: Kühberger Anton , Gradl Patricia 
Published: November 2011

ABSTRACTIn a typical risky choice framing task, people have to choose among two options, which are either positively or negatively framed. Choices in the two framing conditions are then compared. However, different preferences between the conditions can be due to changes in the evaluation of the single constituent options or due to specific processes triggered by the choice task. In order to clarify the source of the framing effect, we investigate the effect with different response modes: choice, rating, and ranking. The rating and ranking findings indicate that what is commonly called a risky choice framing effect is actually a framing effect that changes the evaluation of only the riskless option, although there is little or no effect on the risky option. According to these findings, risky choice framing might be construed as a process of attribute framing, which is independent of risk preference in choice contexts. Copyright © 2011 John Wiley & Sons, Ltd.
Chinese hamster genome database: An online resource for the CHO community at www.CHOgenome.org
Authors: Hammond Stephanie , Kaplarevic Mihailo , Borth Nicole , Betenbaugh Michael J. , Lee Kelvin H. 
Published: November 2011

AbstractThe Chinese hamster genome database (http://www.chogenome.org/) is an online resource for the Chinese hamster (Cricetulus griseus) and Chinese hamster ovary (CHO) cell communities. CHO cells are important for biomedical research and are widely used in industry for the production of biopharmaceuticals. The genome of the CHO‐K1 cell line was recently sequenced and the CHO community has developed an online resource to facilitate accessibility of the genomic data and the development of genomic tools. Biotechnol. Bioeng. 2012; 109:1353–1356. © 2011 Wiley Periodicals, Inc.
Randomized comparison of cost‐saving and effectiveness of oral rapamycin plus bare‐metal stents with drug‐eluting stents: Three‐year outcome from the randomized oral rapamycin in Argentina (ORAR) III trial
Authors: Rodriguez Alfredo E. , Rodriguez‐Granillo Alfredo M. , Antoniucci David , Mieres Juan , Fernandez‐Pereira Carlos , Rodriguez‐Granillo Gaston A. , Santaera Omar , Rubilar Bibiana , Palacios Igor F. , Serruys Patrick W. ,   on behalf of ORAR III Investigators
Published: November 2011

AbstractObjectives: The Oral Rapamycin in ARgentina (ORAR) III trial is a randomized study comparing a strategy of oral rapamycin (OR) plus bare‐metal stent (BMS) versus a strategy of drug‐eluting stents (DES) in patients with de novo coronary lesions. The purpose of this study was to assess the 3 years cost‐effectiveness outcome of each strategy. Background: OR after BMS has been associated with reduction of target vessel revascularization (TVR) although its value in long‐term efficacy in comparison with DES is unknown. Methods: In three hospitals in Buenos Aires, Argentina, 200 patients were randomized to OR plus BMS (n = 100) or DES (n = 100). Primary objectives were costs and effectiveness. Cost analysis included in‐hospital and follow‐up costs. Safety was defined as the composite of death, myocardial infarction (MI), and stroke. Efficacy was defined as TVR. Results: Baseline characteristics between groups were similar. The 3‐year follow‐up rate was 99%. Cardiac mortality was 2% and 5% in OR group and DES group, respectively (P = 0.44). The composite of death, MI and stroke rate was 11% in OR group and 20% in DES group (P = 0.078). TVR rate was 14.5% in OR group and 17.6% in DES group (P = 0.50), respectively. Three year cumulative costs were significantly lower in the OR arm as compared to the DES arm (P = 0.0001) and DES strategy did not result cost‐effective according to the non‐inferiority test. Conclusions: At 3 years follow‐up, there were no differences in effectiveness between the two strategies, and DES strategy was not more cost‐effective as compared to OR plus BMS. © 2011 Wiley Periodicals, Inc.
Characterization of the Mixing and Precipitation of Sonochemical Flow Reactors under Special Consideration of the Reactor Geometry
Authors: Pohl Birte , Jamshidi Rashid , Brenner Gunther , Peuker Urs A. 
Published: November 2011

AbstractNanopartikeln werden durch Fällung vorwiegend in Rührkesseln oder Hochdruck‐T‐Mischern synthetisiert. In der vorliegenden Arbeit wurden zwei Apparategeometrien für kontinuierlich betriebene Reaktoren, die auf eine Fällungsreaktion abgestimmt sind, entwickelt und verglichen. Die Durchmischung der Reaktionspartner erfolgt mittels Ultraschall. Der erste Reaktor hat eine konische Reaktorkammer, in der der Einfluss der Mikromischung, der Mikromischzeit, der Durchsatzrate und der Ultraschallintensität auf die Fällungsergebnisse von Nanopartikeln untersucht wurde. Der zweite Reaktor ist ein Kavitationsfeldreaktor mit einer optimierten Geometrie des konischen Reaktors. Die Möglichkeit zum Scale‐up wird aufgezeigt.
Employee Organizational Citizenship Behaviour: The Direct and Indirect Impact of Ethical Leadership
Authors: Ruiz‐Palomino Pablo , Ruiz‐Amaya Carmen , Knörr Helena 
Published: November 2011

AbstractUsing 525 respondents from the banking and insurance sectors in Spain, supervisor ethical leadership (SEL), conceptualized to involve the practice of moral virtues, was examined for its relationship to employee job satisfaction, affective commitment, and organizational citizenship behaviour. Consistent with social exchange theory, SEL was directly and positively associated with both job satisfaction and affective commitment. The relationship between ethical leadership and employee organizational citizenship was best represented by a model where the effect was fully mediated by job satisfaction and affective commitment. Implications of these findings and suggestions for future research are discussed. Copyright © 2011 ASAC. Published by John Wiley & Sons, Ltd.
Preconcentration by Coprecipitation of Copper and Nickel with Mo(VI)/Triazole Derivative System and Their Determinations by Flame Atomic Absorption Spectrometry in Food and Water Samples
Authors: Ozdes Duygu , Duran Celal , Bayrak Hacer , Bulut Volkan Numan , Tufekcı Mehmet 
Published: November 2011

AbstractA new separation and preconcentration technique based on coprecipitation of Cu(II) and Ni(II) ions by the aid of Mo(VI)/di‐tert‐butyl{methylenebis[5‐(chlorobenzyl)‐4H‐1,2,4‐triazol‐3,4‐diyl]}biscarbamate (BUMECTAC) precipitate has been established. The Mo(VI)/BUMECTAC precipitate was dissolved by concentrated HNO3 and the solution was completed to 5.0 mL with distilled/deionized water. The levels of the analyte ions were determined by flame atomic absorption spectrometer. The effects of experimental conditions like HNO3 concentration, amount of BUMECTAC and Mo(VI), sample volume, etc. and also the influences of some foreign ions were investigated in detail on the quantitative recoveries of analyte ions. The preconcentration factors were found to be 40 for Cu(II) and 100 for Ni(II) ions. The detection limits for Cu(II) and Ni(II) ions based on 3σ (N:10) were 0.43 and 0.70 µg L−1, respectively. The relative standard deviations were found to be lower than 4.0% for both analyte ions. The accuracy of the method was checked by spiked/recovery tests and the analysis of two certified reference materials (Environment Canada TM‐25.3 and CRM‐SA‐C Sandy Soil C). The procedure was successfully applied to sea water and stream water as liquid samples and baby food as solid sample in order to determine the levels of Cu(II) and Ni(II) ions.
Distribution of zebrin‐immunoreactive Purkinje cell terminals in the cerebellar and vestibular nuclei of birds
Authors: Wylie Douglas R. , Pakan Janelle M.P. , Huynh Hang , Graham David J. , Iwaniuk Andrew N. 
Published: November 2011

AbstractZebrin II (aldolase C) is expressed in a subset of Purkinje cells in the mammalian and avian cerebella such that there is a characteristic parasagittal organization of zebrin‐immunopositive stripes alternating with zebrin‐immunonegative stripes. Zebrin is expressed not only in the soma and dendrites of Purkinje cells but also in their axonal terminals. Here we describe the distribution of zebrin immunoreactivity in both the vestibular and the cerebellar nuclei of pigeons (Columba livia) and hummingbirds (Calypte anna, Selasphorus rufus). In the medial cerebellar nucleus, zebrin‐positive labeling was particularly heavy in the “shell,” whereas the “core” was zebrin negative. In the lateral cerebellar nucleus, labeling was not as heavy, but a positive shell and negative core were also observed. In the vestibular nuclear complex, zebrin‐positive terminal labeling was heavy in the dorsolateral vestibular nucleus and the lateral margin of the superior vestibular nucleus. The central and medial regions of the superior nucleus were generally zebrin negative. Labeling was moderate to heavy in the medial vestibular nucleus, particulary the rostral half of the parvocellular subnucleus. A moderate amount of zebrin‐positive labeling was present in the descending vestibular nucleus: this was heaviest laterally, and the central region was generally zebrin negative. Zebrin‐positive terminals were also observed in the the cerebellovestibular process, prepositus hypoglossi, and lateral tangential nucleus. We discuss our findings in light of similar studies in rats and with respect to the corticonuclear projections to the cerebellar nuclei and the functional connections of the vestibulocerebellum with the vestibular nuclei. J. Comp. Neurol. 520:1532–1546, 2012. © 2011 Wiley Periodicals, Inc.
Cross‐layer based power allocation over cognitive wireless relay link with statistical delay QoS guarantees
Authors: Wang Yichen , Ren Pinyi , Li Fan , Su Zhou 
Published: November 2011

SUMMARYIn this paper, we propose a cross‐layer based power allocation scheme with statistical delay QoS guarantees for the cognitive (secondary) amplify‐and‐forward relay link, which coexists with one primary link by sharing particular portion of the spectrum. Specifically, our derived power allocation scheme aims at maximizing the effective capacity of the cognitive relay link, which can be seen as the maximum arrival rate supported by the system under given QoS constraints. In our work, not only the average total transmit power and average interference power constraints are considered, but also the impact of the interference from the primary link to the cognitive relay link is taken into consideration. Simulation results show that the effective capacity of the cognitive relay link varies with the statistical QoS constraints. In particular, the stringent QoS constraint will cause low effective capacity. Moreover, we observe that the average total transmit power and average interference power are two important parameters, which will obviously impact the performance of the cognitive relay link. In addition, we find that the transmission of the primary link will significantly affect the performance of the cognitive relay link, such that a larger transmit power of the primary link will cause the performance degradation of the cognitive relay link. Copyright © 2011 John Wiley & Sons, Ltd.
Using DFT in Search for Support Effects During Methanol Oxidation on Supported Molybdenum Oxides
Authors: Fievez Tim , Geerlings Paul , Weckhuysen Bert M. , De Proft Frank 
Published: November 2011

AbstractThe oxidation of methanol on supported molybdenum oxides was studied using DFT. Starting from a cluster model for a mono‐oxo and di‐oxo molybdenum oxide on a SiO2 support, the reaction energies and rates for the oxidation of methanol were computed and interpreted with chemical reaction indices. This pointed out that the apparent barrier was significantly lower on the mono‐oxide model, favoring it over the di‐oxo species. Accordingly, we assumed similar behavior on Al2O3, TiO2 and ZrO2 supports, so that we could compare characteristics over different supports. The obtained reaction energies and rates followed the experimental turn‐over frequency (TOF) sequence.
Distributed topology control in large‐scale hybrid RF/FSO networks: SIMT GPU‐based particle swarm optimization approach
Authors: Awwad Osama , Al‐Fuqaha Ala , Ben Brahim Ghassen , Khan Bilal , Rayes Ammar 
Published: November 2011

SUMMARYThe tremendous power of graphics processing unit (GPU) computing relative to prior CPU‐only architectures presents new opportunities for efficient solutions of previously intractable large‐scale optimization problems. Although most previous work in this field focused on scientific applications in the areas of medicine and physics, here we present a Compute Unified Device Architecture‐based (CUDA) GPU solution to solve the topology control problem in hybrid radio frequency and free space optics wireless mesh networks by adapting and adjusting the transmission power and the beam‐width of individual nodes according to QoS requirements. Our approach is based on a stochastic global optimization technique inspired by the social behavior of flocking birds — so‐called ‘particle swarm optimization’ — and was implemented on the NVIDIA GeForce GTX 285 GPU. The implementation achieved a performance speedup factor of 392 over a CPU‐only implementation. Several innovations in the memory/execution structure in our approach enabled us to surpass all prior known particle swarm optimization GPU implementations. Our results provide a promising indication of the viability of GPU‐based approaches towards the solution of large‐scale optimization problems such as those found in radio frequency and free space optics wireless mesh network design. Copyright © 2011 John Wiley & Sons, Ltd.
TNFR2 on non‐haematopoietic cells is required for Foxp3+ Treg‐cell function and disease suppression in EAE
Authors: Tsakiri Niki , Papadopoulos Dimitrios , Denis Maria C. , Mitsikostas Dimos‐Dimitrios , Kollias George 
Published: November 2011

AbstractThe TNF/TNFR system exerts multiple proinflammatory and immunosuppressive functions in the pathogenesis of chronic inflammation and autoimmunity. In EAE, the experimental model of Multiple Sclerosis (MS), genetic ablation of TNFR2, results in exacerbated immune reactivity and chronic disease course. The underlying mechanism driving this immunosuppressive function of TNFR2 remains unclear. We show here that chronic exacerbated EAE in TNFR2 KO mice is associated with increased Th17‐cell responses and reduced numbers of Foxp3+ Treg cells both in the spinal cord and peripheral lymphoid organs. Treg cells from TNFR2‐deficient animals developing EAE show decreased proliferative and suppressive functions, both ex vivo and in vivo, and appear responsible for the exacerbated non‐remitting disease, as evidenced by phenotypic rescue following adoptive transfer of Treg cells from WT but not TNFR2−/− donors. Reciprocal BM transplantation experiments between WT and TNFR2‐deficient mice demonstrated that the capacity of TNFR2 to support Treg‐cell expansion and function during EAE is non‐intrinsic to Treg or other haematopoietic cells but requires expression of TNFR2 in radiation‐resistant cells of the host. These results reveal a previously unsuspected role for non‐haematopoietic TNFR2 in modulating Treg‐cell expansion and immune suppression during development of autoimmunity and suggest that a similar mechanism may affect chronicity and relapses characterizing human autoimmune disease, including MS.
IFN‐γ elevates airway hyper‐responsiveness via up‐regulation of neurokinin A/neurokinin‐2 receptor signaling in a severe asthma model
Authors: Kobayashi Minoru , Ashino Shigeru , Shiohama Yasuo , Wakita Daiko , Kitamura Hidemitsu , Nishimura Takashi 
Published: November 2011

AbstractThe adoptive transfer of OVA‐specific Th1 cells into WT mice followed by OVA inhalation induces a significant elevation of airway hyper‐responsiveness (AHR) with neutrophilia but not mucus hypersecretion. Here, we demonstrate that the airway inflammation model, pathogenically characterized as severe asthma, was partly mimicked by i.n. administration of IFN‐γ. The administration of IFN‐γ instead of Th1 cells caused AHR elevation but not neutrophilia, and remarkably induced neurokinin‐2 receptor (NK2R) expression along with neurokinin A (NKA) production in the lung. To evaluate whether NKA/NK2R was involved in airway inflammation, we first investigated the role of NKA/NK2R‐signaling in airway smooth muscle cells (ASMCs) in vitro. NK2R mRNA expression was significantly augmented in tracheal tube‐derived ASMCs of WT mice but not STAT‐1−/− mice after stimulation with IFN‐γ. In addition, methacholine‐mediated Ca2+ influx into the ASMCs was significantly reduced in the presence of NK2R antagonist. Moreover, the NK2R antagonist strongly inhibited IFN‐γ‐dependent AHR elevation in vivo. Thus, these results demonstrated that IFN‐γ directly acts on ASMCs to elevate AHR via the NKA/NK2R‐signaling cascade. Our present findings suggested that NK2R‐mediated neuro‐immuno crosstalk would be a promising target for developing novel drugs in Th1‐cell‐mediated airway inflammation, including severe asthma.
Affinity maturation of antibodies requires integrity of the adult thymus
Authors: AbuAttieh Mouhammed , Bender Diane , Liu Esther , Wettstein Peter , Platt Jeffrey L. , Cascalho Marilia 
Published: November 2011

AbstractThe generation of B‐cell responses to proteins requires a functional thymus to produce CD4+ T cells which helps in the activation and differentiation of B cells. Because the mature T‐cell repertoire has abundant cells with the helper phenotype, one might predict that in mature individuals, the generation of B‐cell memory would proceed independently of the thymus. Contrary to that prediction, we show here that the removal of the thymus after the establishment of the T‐cell compartment or sham surgery without removal of the thymus impairs the affinity maturation of antibodies. Because removal or manipulation of the thymus did not decrease the frequency of mutation of the Ig variable heavy chain exons encoding antigen‐specific antibodies, we conclude that the thymus controls affinity maturation of antibodies in the mature individual by facilitating the selection of B cells with high‐affinity antibodies.
Orthogonal Protecting Groups in the Synthesis of Tryptophanyl‐Hexahydropyrroloindoles
Authors: Ruiz‐Sanchis Pau , Savina Svetlana A. , Acosta Gerardo A. , Albericio Fernando , Álvarez Mercedes 
Published: November 2011

AbstractThe synthesis of various polycyclic systems containing aC3a–Ni bond between a hexahydropyrrolo[2,3‐b]indole and an indole tryptophan is described here. A series of experiments were performed to determine the best combination of five orthogonal protecting groups and the best reaction conditions for formation of said bond, which is a common feature among many recently discovered marine natural products.
A Straightforward Approach to MMP‐2 and MMP‐9 Inhibitors Based on Chelate Claisen Rearrangements
Authors: Burkhart Jens L. , Diehl Björn , Schmitt Manfred J. , Kazmaier Uli 
Published: November 2011

AbstractThe chelate Claisen rearrangement is a versatile tool for the stereoselective synthesis of β‐substituted γ,δ‐unsaturated amino acids, which can be converted into β‐substitutedaspartates by oxidative cleavage. These are ideal precursors for the synthesis of hydroxamate‐type MMP inhibitors.
The brain tumor microenvironment
Authors: Charles Nikki A. , Holland Eric C. , Gilbertson Richard , Glass Rainer , Kettenmann Helmut 
Published: November 2011

AbstractHigh‐grade brain tumors are heterogeneous with respect to the composition of bona fide tumor cells and with respect to a range of intermingling parenchymal cells. Glioblastomas harbor multiple cell types, some with increased tumorigenicity and stem cell‐like capacity. The stem‐like cells may be the cells of origin for tumor relapse. However, the tumor‐associated parenchymal cells such as vascular cells, microglia, peripheral immune cells, and neural precursor cells also play a vital role in controlling the course of pathology. In this review, we describe the multiple interactions of bulk glioma cells and glioma stem cells with parenchymal cell populations and highlight the pathological impact as well as signaling pathways known for these types of cell‐cell communication. The tumor‐vasculature not only nourishes glioblastomas, but also provides a specialized niche for these stem‐like cells. In addition, microglial cells, which can contribute up to 30% of a brain tumor mass, play a role in glioblastoma cell invasion. Moreover, non‐neoplastic astrocytes can be converted into a reactive phenotype by the glioma microenvironment and can then secrete a number of factors which influences tumor biology. The young brain may have the capacity to inhibit gliomagenesis by the endogenous neural precursor cells, which secrete tumor suppressive factors. The factors, pathways, and interactions described in this review provide a new prospective on the cell biology of primary brain tumors, which may ultimately generate new treatment modalities. However, our picture of the multiple interactions between parenchymal and tumor cells is still incomplete. © 2011 Wiley Periodicals, Inc.
Caveolin-1 orchestrates the balance between glucose and lipid-dependent energy metabolism: Implications for liver regeneration
Authors: Fernández-Rojo Manuel Alejandro , Restall Christina , Ferguson Charles , Martel Nick , Martin Sally , Bosch Marta , Kassan Adam , Leong Gary M. , Martin Sheree D. , McGee Sean L. , Muscat George E.O. , Anderson Robin L. , Enrich Carlos , Pol Albert , Parton Robert G. 
Published: November 2011

Abstract

Caveolin-1 (CAV1) is a structural protein of caveolae involved in lipid homeostasis and endocytosis. Using newly generated pure Balb/C CAV1 null (Balb/CCAV1−/−) mice, CAV1−/− mice from Jackson Laboratories (JAXCAV1−/−), and CAV1−/− mice developed in the Kurzchalia Laboratory (KCAV1−/−), we show that under physiological conditions CAV1 expression in mouse tissues is necessary to guarantee an efficient progression of liver regeneration and mouse survival after partial hepatectomy. Absence of CAV1 in mouse tissues is compensated by the development of a carbohydrate-dependent anabolic adaptation. These results were supported by extracellular flux analysis of cellular glycolytic metabolism in CAV1-knockdown AML12 hepatocytes, suggesting cell autonomous effects of CAV1 loss in hepatic glycolysis. Unlike in KCAV1−/− livers, in JAXCAV1−/− livers CAV1 deficiency is compensated by activation of anabolic metabolism (pentose phosphate pathway and lipogenesis) allowing liver regeneration. Administration of 2-deoxy-glucose in JAXCAV1−/− mice indicated that liver regeneration in JAXCAV1−/− mice is strictly dependent on hepatic carbohydrate metabolism. Moreover, with the exception of regenerating JAXCAV1−/− livers, expression of CAV1 in mice is required for efficient hepatic lipid storage during fasting, liver regeneration, and diet-induced steatosis in the three CAV1−/− mouse strains. Furthermore, under these conditions CAV1 accumulates in the lipid droplet fraction in wildtype mouse hepatocytes.

Conclusion:

Our data demonstrate that lack of CAV1 alters hepatocyte energy metabolism homeostasis under physiological and pathological conditions. (Hepatology 2011)