bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cognitive segmentation: Modeling the structure and content of customers' thoughts
Authors: Carrillat François A. , Riggle Robert J. , Locander William B. , Gebhardt Gary F. , Lee James M. 
Published: May 2009

AbstractThis paper proposes a cognitive segmentation technique that models both customers' cognitive content and structure. Cognitive segmentation provides a quantitative operationalization of idiographic cognitions that can be compared and integrated across customers to move beyond the in‐depth understanding and wide generalizing trade‐off. In addition, cognitive segmentation utilizes participants' own semantics for eliciting and aggregating cognitions. This method allows researchers to understand content in light of structure, as participants' elicited cognitive contents are further interpreted as a function of the complexity of their cognitive structures. The conceptual foundations from personal construct theory as well as a description of the nine‐step implementation process whereby participants fill out a modified version of Kelly's Repertory Grid and complete Borman's trait implication procedure are provided. An application illustrates how cognitive segmentation can identify and assess the size potential of each customer target as a function of their cognitive content and structure. A discussion of the results and directions for further research are also provided. © 2009 Wiley Periodicals, Inc.
The role of consideration sets in brand choice: The moderating role of product characteristics
Authors: Suh Jung‐Chae 
Published: May 2009

AbstractThis study investigates the role of consideration sets in brand choice. Brand‐level aggregated data are used to capture the responses of consumers who face a number of international and domestic brands in markets rather than two or three brands in experimental designs, as in Chaudhuri and Holbrook (2001). Empirical evidence from path analysis shows that the consideration set for hedonic products includes a smaller number of dominant brands, whereas the consideration set for utilitarian products includes more and diverse brands. The probability of being finally chosen from the consideration set differs according to product characteristics: hedonic vs. utilitarian. The authors discuss managerial implications and suggestions for future research. © 2009 Wiley Periodicals, Inc.
Neurochemical biomarkers in the differential diagnosis of movement disorders
Authors: Mollenhauer Brit , Trenkwalder Claudia 
Published: May 2009

AbstractIn recent years, the neurochemical analysis of neuronal proteins in cerebrospinal fluid (CSF) has become increasingly accepted for the diagnosis of neurodegenerative dementia diseases such as Alzheimer's disease and Creutzfeldt–Jakob disease. CSF surrounds the central nervous system, and in the composition of CSF proteins one finds brain‐specific proteins that are prioritized from blood‐derived proteins. Levels of specific CSF proteins could be very promising biomarkers for central nervous system diseases. We need the development of more easily accessible biomarkers, in the blood. In neurodegenerative diseases with and without dementia, studies on CSF and blood proteins have investigated the usefulness of biomarkers in differential diagnosis. The clinical diagnoses of Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, progressive supranuclear palsy, and corticobasal degeneration still rely mainly on clinical symptoms as defined by international classification criteria. In this article, we review CSF biomarkers in these movement disorders and discuss recent published reports on the neurochemical intra vitam diagnosis of neurodegenerative disorders (including recent CSF α‐synuclein findings). © 2009 Movement Disorder Society
The clinical spectrum of stereotypies in frontotemporal lobar degeneration
Authors: Mateen Farrah J. , Josephs Keith A. 
Published: May 2009

AbstractWe clinically assessed patients meeting international criteria for frontotemporal lobar degeneration (FTLD) for the presence and characteristics of stereotypies. Of 32 subjects with FTLD (50% women), 19 (60%) had stereotypies. The majority of patients with stereotypies were female (68%). The median age of symptom onset suggestive of FTLD was 58 years (range: 37–74), with a mean time to stereotypy onset of 2.1 years. In all cases, the stereotypies were simple. There were no differences in the age of FTLD onset, functional imaging results, neuropsychological test scores or frequency of mood disorders or psychoses between those with and without stereotypical movements. However, compulsive behavior was noted more often in those with stereotypies (58% vs. 15%, P = 0.02). Of the 19 patients with stereotypies, three had vocal stereotypies, and three had both vocal and motor stereotypies. Of the 16 subjects with motor stereotypies, 9(56%) were appendicular and 7 (44%) were craniocervical. © 2009 Movement Disorder Society
Pharmacokinetic‐pharmacodynamic crossover comparison of two levodopa extension strategies
Authors: LeWitt Peter A. , Jennings Danna , Lyons Kelly E. , Pahwa Rajesh , Rabinowicz Adrian L. , Wang James , Guarnieri Maria , Hubble Jean P. , Murck Harold 
Published: May 2009

AbstractControlled‐release carbidopa and levodopa (CL‐CR) and the combination of carbidopa, levodopa, and entacapone (CLE) are used for extending levodopa (L‐dopa) effects. In a randomized, open‐label crossover study of 17 PD subjects with wearing‐off responses, we compared 8‐hour L‐dopa pharmacokinetics (PK) and clinical effects after two doses of CL‐CR (50 and 200 mg, respectively) and CLE (37.7, 150, 200 mg, respectively). PK analysis revealed the anticipated near‐equivalent mean L‐dopa area‐under‐the‐concentration‐curve values (639,490 ng min/mL for two doses of CLE, and 662,577 for CL‐CR, P = 0.86). The mean hourly fluctuation index for L‐dopa concentration was 235% for CLE and 196% for CL‐CR (P = 0.004). The mean maximal concentration for the first CLE dose was 1,926 ± 760 ng/mL and for CL‐CR, 1,840 ± 889 (P = 0.33). During the PK studies, the mean time that L‐dopa concentration was ≥1,000 ng/mL for CLE was 291 ± 88 minutes and for CL‐CR, 306 ± 86 (P = 0.33). The mean percent‐time in “off” state was 18% for CLE and 28% for CL‐CR (P = 0.017), “on state without dyskinesia” was 64% for CLE and 65% for CL‐CR (P = 0.803), and “on state with nontroublesome dyskinesia” was 18% for CLE and 7% for CL‐CR (P = 0.03). Despite less “off” time with CLE, both formulations demonstrated similar mean PK values and marked intersubject PK variability. © 2009 Movement Disorder Society
Aniline/α‐cyano‐4‐hydroxycinnamic acid is a highly versatile ionic liquid for matrix‐assisted laser desorption/ionization mass spectrometry
Authors: Calvano Cosima D. , Carulli Saverio , Palmisano Francesco 
Published: May 2009

AbstractThe performance of a matrix‐assisted laser desorption/ionization (MALDI) ionic liquid matrix (ILM) consisting of α‐cyano‐4‐hydroxycinnamic acid (CHCA) and aniline (ANI) was evaluated to assess whether it could offer possible advantages over conventional matrices. Ultraviolet (UV), Fourier transform infrared (FTIR), nuclear magnetic resonance (NMR) and laser desorption/ionization mass spectrometry (LDI‐MS) experiments were carried out with the aim of confirming the structure of the ANI‐CHCA ILM. Different model analytes such as amino acids, peptides, proteins, lipids, phospholipids, synthetic polymers, and sugars were tested. Mass spectra with similar or improved signal‐to‐noise (S/N) ratio (compared to CHCA) were invariably obtained demonstrating the potential of this ILM as a general purpose matrix. Furthermore, protein identification by peptide mass fingerprinting (PMF) and database search was facilitated compared to CHCA since higher scores and increased sequence coverage were observed. Finally, a complex lipid mixture (i.e. a raw extract of a milk sample) analysed by MALDI‐MS showed improved S/N ratio, a reduced chemical noise and a limited formation of matrix‐clusters. Copyright © 2009 John Wiley & Sons, Ltd.
A simple rapid method to precisely determine 13C/12C ratios of plant methoxyl groups
Authors: Greule Markus , Mosandl Armin , Hamilton John T. G. , Keppler Frank 
Published: May 2009

AbstractStable isotope ratios of individual plant components have become a valuable tool for the determination of the geographical origin and authenticity of foodstuff. A recently published method with considerable potential in this context is the measurement of the deuterium/hydrogen (D/H) isotope ratios of plant matter methoxyl groups. The method entailed cleavage of methyl ethers or esters with hydriodic acid (HI) to form gaseous methyl iodide (CH3I) and then measurement of the δ2H value of this gas. Here, as a follow up to a previous study, we describe a method for the rapid and precise δ13C analysis of plant matter methoxyl groups using gas chromatography/combustion/isotope ratio mass spectrometry (GC/C/IRMS). Conditions for sample preparation were investigated for isotope discrimination effects, the GC conditions optimized, the reproducibility of the measurement of standards undertaken, and the precision of the method defined. The reproducibility of the δ13C value determined for a CH3I standard on 20 consecutive measurements was found to be 0.17‰. The method was also tested on four methoxyl‐rich plant components: vanillin, lignin, wood and pectin. The analytical precision obtained, expressed as the average standard deviation, for these compounds was found to be better than 0.13‰. The described procedure which is simple and rapid, allowing preparation and analysis of a sample within 1 h, produces accurate and reproducible isotopic measurements. We suggest that this validated δ13C method when employed together with the recently published δ2H method for two‐dimensional stable isotope studies of organic matter containing methoxyl groups will be of considerable value, e.g. for proving the authenticity of foodstuff. Copyright © 2009 John Wiley & Sons, Ltd.
Studies of keratins in tongue coating samples of hepatitis B patients by mass spectrometry
Authors: Fang Fang , Liu Ping , Wang Haoyang , Zhang Li , Zhang Jing , Gao Yuping , Zeng Liming , Guo Yinlong 
Published: May 2009

AbstractPooled tongue coating samples from 64 hepatitis B patients and 24 healthy adults were studied and a major band of differential proteins was found by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS‐PAGE). The differential proteins in this band were identified and proved to be keratins by liquid chromatography/tandem mass spectrometry (LC/MS/MS) and Western blot analysis. Furthermore, relative quantification of the identified keratins was performed via using stable isotopic labeling and matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry (MALDI‐TOF MS), showing the higher expression level of these keratins in tongue coating samples of hepatitis B patients than healthy adults. These results provided additional information to understand the medical diagnosis depending on the tongue coating. Copyright © 2009 John Wiley & Sons, Ltd.
Determination of the optical constants of solar‐control amorphous silicon thin films on float glass
Authors: Liu Yong , Ni Lihong , Liu Jun Bo , Liu Qiying , Song Chenlu , Han Gaorong 
Published: May 2009

AbstractAn improved method employing a modified Forouhi and Bloomer disperse model with a hybridized simulated annealing algorithm is implemented in this paper, allowing the determination of refractive index, extinction coefficient, and thickness of a‐Si films at one time by fitting reflectance and transmitted spectra. The thickness of films obtained by this method has a reasonable agreement with the result by ellipsometric measurement, especially for samples with thickness in the range of 40–80 nm. The presented method exhibits low time consumption and cost, which implies a possibility of usage in real‐time on‐line measurement of solar‐control coatings on float glass. Copyright © 2009 John Wiley & Sons, Ltd.
Nicotinamide Rescues Human Embryonic Stem Cell-Derived Neuroectoderm from Parthanatic Cell Death
Authors: Cimadamore Flavio , Curchoe Carol Lynn , Alderson Nazilla , Scott Fiona , Salvesen Guy , Terskikh Alexey V. 
Published: May 2009

Abstract
Abundant cell death is observed when human embryonic stem cells (hESCs) undergo neuralization, a critical first step for future cell-based therapies addressing neurodegeneration. Using hESC neuralization as an in vitro model of human development, we demonstrated that the developing neuroepithelium acquires increased susceptibility to spontaneous cell death. We found that poly(ADP-ribose) polymerase-1 (PARP1)/apoptosis-inducing factor (AIF)-mediated cell death (parthanatos) is a dominant mechanism responsible for cell loss during hESC neuralization. The demise of neural progenitor cells, at least in part, is due to decreased endogenous antioxidant defenses and enhanced reactive oxygen species leakage from mitochondria fuelled by nonphysiological culture conditions. Under such conditions, PARP1 overactivation triggered cell death through the mitochondrial-nuclear translocation of AIF. Blocking PARP1 activity with small hairpin RNA interference or nicotinamide dramatically enhanced hESC neuralization, providing optimal survival of the developing neuroepithelium. Because nicotinamide is a physiological metabolite, our results raise the possibility that neural stem/progenitor cell survival in vivo requires a metabolic niche. We argue that small natural metabolites provide a powerful physiological tool to optimize hESC differentiation compatible with the requirements of regenerative medicine.
Disclosure of potential conflicts of interest is found at the end of this article.
Novel STAT3 Target Genes Exert Distinct Roles in the Inhibition of Mesoderm and Endoderm Differentiation in Cooperation with Nanog
Authors: Bourillot Pierre-Yves , Aksoy Irène , Schreiber Valerie , Wianny Florence , Schulz Herbert , Hummel Oliver , Hubner Norbert , Savatier Pierre 
Published: May 2009

Abstract
Leukemia inhibitory factor (LIF) activates the transcription factor signal transducer and activator of transcription 3 (STAT3), which results in the maintenance of mouse embryonic stem cells in the pluripotent state by inhibiting both mesodermal and endodermal differentiation. How the LIF/STAT3 pathway inhibits commitment to both mesoderm and endoderm lineages is presently unknown. Using a hormone-dependent STAT3 and with microarray analysis, we identified 58 targets of STAT3 including 20 unknown genes. Functional analysis showed that 22 among the 23 STAT3 target genes analyzed contribute to the maintenance of the undifferentiated state, as evidenced by an increase in the frequency of differentiated colonies in a self-renewal assay and a concomitant elevation of early differentiation markers upon knockdown. Fourteen of them, including Dact1, Klf4, Klf5, Rgs16, Smad7, Ccrn4l, Cnnm1, Ocln, Ier3, Pim1, Cyr61, and Sgk, were also regulated by Nanog. Analysis of lineage-specific markers showed that the STAT3 target genes fell into three distinct categories, depending on their capacity to inhibit either mesoderm or endoderm differentiation or both. The identification of genes that harness self-renewal and are downstream targets of both STAT3 and Nanog shed light on the mechanisms underlying functional redundancy between STAT3 and Nanog in mouse embryonic stem cells.
Disclosure of potential conflicts of interest is found at the end of this article.
Ultramafic Breccias from the Musa Valley, Eastern Papua
Authors: Green D. H. 
Published: May 2009

AbstractIn the Musa Valley area rocks of the Papuan Ultramafic Belt outcrop discontinuously over an area of 25 miles by 45 miles. The rocks are part of a folded layered sequence ranging from magnesian dunite and peridotite, chemically and petrographically typical of the alpine ultramafic suite, to olivine gabbro and bytownite gabbro. Agglomerate like breccias consisting of fragments of ultramafic rock in a variable matrix occur as irregular vent-like bodies in the peridotite and dunite and as horizontal sheets in a Pleistocene-Recent sedimentary sequence. The breccias are interpreted as vent and extrusive breccias resulting from the penetration, brecciation and local entrainment (fluidization) of peridotitic country rock by volcanic gases. Olivine alkali basalt was probably the parental magma responsible for the gaseous activity. The breccias show a sequence of stability fields for the assemblages mesh-texture serpentine and bastite (i.e. chrysotile and lizardite mixtures); antigorite; olivine and enstatite; and these are correlated qualitatively with variation in intensity of the brecciation process. Chemically the brecciation process was responsible for the addition of H2O, SiO2, CO2, Al2O3 and O2 and the removal of Fe and Mg from the fragmented rock. Minerals which are of direct crystallization in the matrix fluid environment include chalcedony, fibrous serpentine (chrysotile), magnesite, quartz, andradite, and garnierite. There is no evidence of the presence of an ultramafic, serpentine magma in the genesis of the breccias.
Structural Evidence for a Palaeozoic Orogeny in North-west Malaya
Authors: Koopmans B. N. 
Published: May 2009

AbstractLower Palaeozoic rocks in the Langkawi Islands have been subject to three generations of deformation. In the slightly dynamo-meta-morph slates in the south-east two generations of cleavage folding have been developed with a N.N.W. trend. The first resulted in a recumbent folding with a subhorizontal slaty cleavage, whereas during the second generation the slaty cleavage was deformed in open folds and a crenulation cleavage developed in the steep limbs. The two deformations were probably not formed at exactly the same time, but seem to be related with each other. Boudinage of granite sills was contemporaneous with the development of the slaty cleavage.In the unmetamorphosed northern part of the area cross-folding is found. Flexure folds with a N.W. trend are superimposed on folds with a N.N.E. trend. In the Upper Palaeozoic sediments such deformations are missing. The Permian and Carboniferous strata show only a slight warping around the granite batholith which was intruded during Jurassic time (Pacific orogeny). A similar warping is found in the large low-angle overthrust, in which Silurian was thrust over Permo-Carboniferous. Consequently this thrust plane is dated as pre-granitic and post Permo-Carboniferous. Contact metamorphism by the granite intrusion has resulted in hornfelses in the Permo-Carboniferous sequence and in the development of oriented minerals, mainly clinozoisite, in the Ordovician-Silurian slates. Knick zones and intense jointing parallel with the mineral orientation (third generation structures) are also a result of the granite intrusion.The first two generations of folding, which are not present in the Upper Palaeozoic beds, are products of an erogenic phase, “the Langkawi folding phase,” during late Silurian-Devonian time. The lack of Devonian strata in Thailand and the incompleteness of the Devonian sequence in Malaya (recently a few outcrops of probably Middle-Upper Devonian strata are found along the west coast of Malaya) can be an indication that the Langkawi folding phase is not restricted to the Langkawi Islands.
Some Problems of Classification in the Canadian Pre-Cambrian Shield.
Authors: Wilson M. E. 
Published: May 2009

The region lying along the southern border of the Canadian Shield, the St. Lawrence basin, to which by far the greater part of the field work so far performed in this vast area has been confined, is divided into four geographically separate sub-provinces, in each of which the succession of formations is so different that few positive correlations of either formations or unconformities in different sub-provinces can be made. It is probable, however, that all geologists familiar with this region are agreed that there is a palaeoplain at the base of the Huronian that originally at least extended over the southern part of the Canadian Shield. If the existence of this palaeoplain be assumed as established then there are two major problems in Pre-Cambrian classification in this region that remain unsolved: (1) What is the position of the pre-Huronian palaeoplain in the succession of formations present in the sub-province north-west of Lake Superior and in the Grenville sub-province? and (2) is there a second erosion plain within the pre-Huronian complex, and, if so, can it be used satisfactorily for the classification of the pre-Huronian into two major divisions equivalent in rank to the Huronian?The purpose of this paper has been to point out (1) that there is no present agreement regarding the solution of either of these problems; (2) that the existence of a widespread unconformity within the pre-Huronian complex of the St. Lawrence province is, as yet, only a hypothesis, and (3) that there are only two logical courses to be followed in the classification of the Pre-Cambrian formations of the Canadian Shield, either to adopt the dual classification or to use it tentatively in the manner indicated in the accompanying table, until the existence of the second widespread unconformity is established or disproved. It may be suggested, however, that since considerable difficulty is being encountered in applying the dual classification even within the St. Lawrence province, it may be more practical to adopt the dual classification for the major divisions of the Pre-Cambrian notwithstanding the possible presence of an unconformity within the pre-Huronian complex.In conclusion the writer wishes to express his indebtedness to his colleagues of the Geological Survey of Canada, W. H. Collins, F. J. Alcock, T. L. Tanton, and J. F. Wright, for criticism of the columns in the table of formations having reference to the different sub-provinces with which they are especially familiar.
The palaeogeographic position of the Lake District in the early Ordovician
Authors: Fortey R. A. , Owens R. M. , Rushton A. W. A. 
Published: May 2009

AbstractThe early Ordovician was a time of maximum continental separation and hence a time when faunal evidence can be used to assess palaeogeography in a critical way. We summarize the known trilobite occurrences (18 genera) from the Arenig–Llanvirn of the Lake District, and record some genera for the first time. Maps of the distribution of some of these forms are given. All genera exceptCyclopygewere confined to the Gondwana continent at the time, and some are known from many localities; and two species are widespread in England, Wales, France, Iberia and Bohemia. The fauna is entirely distinct from those of Scandinavia and North America. All the palaeontological evidence points to the Lake District being adjacent to Ordovician Gondwana. In the earlier Ordovician it is not reasonable to suggest that the Iapetus Ocean lay to the south of the Lake District as did Allen (1987).