bluuebunny/crossref_metadata_2025_split huggingface dataset:
Follow-up of Methanol-related Visual Defects in a Cohort Study: Initial Severity Predicts Long-term Outcome
Authors: Gheshlaghi Farzad , Wong Anselm , Firuzfar Rezvan , Jenab Keyvan , Gheshlaghi Shayan , Shahverdi Golnoosh , Eizadi-Mood Nastaran 
Published: April 2024

Objective:Methanol poisoning can occur either intentionally through the consumption of methanol-containing products or accidentally through ingestion, resulting in visual impairment. We assessed the long-term visual sequelae in patients with methanol poisoning.Methods:This prospective cohort study was conducted at referral centers, Khorshid and Alzahra University Hospitals, affiliated with Isfahan University of Medical Sciences, Isfahan, Iran. The study included patients hospitalized for methanol poisoning from June 22, 2018, to June 21, 2020, with follow-up extended until June 2021. Toxico-clinical and ophthalmologic examination data were collected from patients upon hospital admission, discharge, and during follow-up.Findings:Thirty-nine patients were assessed in this study. The majority of them (94.9%) were male, with an average age of 34 years. Patients who presented with reduced visual acuity (VA) upon admission subsequently showed abnormalities (in acuity and visual fields) during follow-up (n= 13). Among the patients who displayed visual field defects on admission, bilateral optic disc atrophy was observed in follow-up (n= 13). Conversely, patients who reported blurred vision, with or without photophobia upon admission, had normal results in their follow-up eye examinations. Among the 36 patients who underwent dialysis, 14 (38.9%) exhibited visual impairment during follow-up examinations. Additionally, 38 patients received sodium bicarbonate, and 14 of them (36.85%) also presented ocular abnormalities.Conclusion:Patients who demonstrated VA deficits upon admission are more likely to experience long-term VA and visual field defects, as well as optic disc atrophy. Patients who solely complained of blurred vision, with or without photophobia, during admission were less likely to develop long-term visual defects.
The impact of Charles Bonnet syndrome in patients with age-related macular degeneration
Authors: Pereira Gilberto Sales , Serracarbassa Pedro Durães , Mascato Vitória Herrera Sadala , de Faria Bruna Alvernaz , Silva Fabrício Afonso Borges , de Andrade Eric Pinheiro , Silva Sonia Maria César de Azevedo 
Published: April 2024

Abstract

Introduction:
Charles Bonnet syndrome (CBS) is a condition related to patients having complex visual hallucinations and visual loss due to ophthalmologic disease, without cognitive impairment. CBS is an important differential diagnosis of dementia syndromes, and the correct diagnosis has a great impact on the quality of life of those who suffer from the stigma of psychiatric disease.

Objective:
The objective of the present study is to determine the impact and review symptoms of CBS in patients with visual loss due to age-related macular degeneration (AMD) by using a questionnaire.

Method:
Sixty patients suffering from AMD were forwarded from the Retina Sector of the Ophthalmology Service of the Hospital do Servidor Público Estadual de São Paulo to the Low Vision Sector for a cognitive assessment questionnaire.

Results:
Of the 60 patients studied, 10 were diagnosed with CBS, thus representing 16.6% of the incidence of CBS cases in individuals with AMD. Among these 10 cases, males represented 30% versus females who represented 70% of the total. Patients over 80 years old represented 50% of those who were diagnosed with CBS. CBS represents an important co-diagnosis in AMD patients.

Conclusion:
The research highlights the utility of the cognitive assessment questionnaire as a valuable tool for easily diagnosing the syndrome in patients with AMD. This tool facilitates the identification of the condition, enabling the recommendation of appropriate clinical treatments and the provision of essential psychosocial support.
Eosinophilic Inflammation in Chronic Obstructive Pulmonary Disease: A Treatable Trait
Authors: Govindan Bindu Cheriattil , Augustine Preethi 
Published: April 2024

AbstractCOPD remains to be a giant public health burden and is the third leading cause of death worldwide. The presence of eosinophilic inflammation indicates a distinct pathophysiologic phenotype in COPD with a differential risk profile and response to therapy. Blood eosinophilia, clinical judgement and other patient centred factors helps in developing individualized treatment plans for patients with COPD. Appropriate management of eosinophilic airway inflammation will have an impact on lung function decline and exacerbations, thereby causing significant improvement in morbidity and mortality associated with COPD.
An Adult with Exertional Breathlessness after Cardiac Surgery
Authors: Gowrinath Karanam 
Published: April 2024

Abstract
Iatrogenic complications such as phrenic nerve injury are common during cardiac surgery. Sometimes, unilateral phrenic nerve injury during cardiac surgery may result in persistent weakness or paralysis which may manifest as exertional breathlessness months later with mild restrictive ventilatory defect on spirometry and elevated hemidiaphragm on chest X-ray.
Risk factors for reoperation after discectomy of lumbar herniated intervertebral disc disease
Authors: Peng Cheng-Huan , Chen Ing-Ho , Yu Tzai-Chiu , Wang Jen-Hung , Wu Wen-Tien , Yeh Kuang-Ting 
Published: April 2024

ABSTRACT

Objectives:
Discectomy is the most common surgery for lumbar herniated intervertebral disc (HIVD) disease. However, 5%–24% of patients undergo a second surgery due to recurrent disc herniation.

Materials and Methods:
This study was aimed to identify the risk factors for reoperation after discectomy of lumbar HIVD and recommend treatment for patients with a high risk of reoperation. We recruited patients diagnosed as having single-level lumbar HIVD who underwent open discectomy from January 1, 2000, to December 31, 2012 in our hospital. We used a survival curve to inspect the survival time and reoperation rate after surgery. We discussed the correlation of reoperation rate with discectomy level, body mass index, heavy lifting after surgery, sex, and age. Furthermore, we investigated the correlation between the experience of a surgeon and the reoperation rate.

Results:
A total of 619 patients were enrolled in our study. Most patients were 40–60 years old (48.8%), and most of them had herniation at L4/5 level (48.9%). The 8-year survival rate was 92%. Weight lifting after surgery may increase the reoperation rate by 115 and 18 times for those >60 years and <40 years, respectively. In addition, less experience of the surgeon and female sex had a high reoperation rate.

Conclusion:
Postoperative working modification may be very important for preventing patients from recurrent HIVD. For elderly people with HIVD, a more conservative therapy could be selected. If patients with lumbar spine hypermobility or severe degeneration require wide laminectomy, primary fusion should be considered.
Utilization of apitherapy in allergic asthma: A systematic review of clinical and preclinical studies
Authors: Widjanarko Nicolas Daniel , Subagya Jonathan Christianto , Maksi Josephine Immanuel , Suryatenggara Felicia Grizelda , Sihole Sharon Claudia Ethelyn 
Published: April 2024

ABSTRACT

Objectives:
This systematic review aimed to summarize the benefit of apitherapy in human and animal models of asthma.

Materials and Methods:
The procedures in this review were performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis 2020 protocol, where MEDLINE, ProQuest, and EBSCOhost databases were used to obtain eligible studies dating to 2023. Furthermore, the risk of bias was assessed using Risk of Bias Tool 2.0 (RoB-2) for randomized-control trials and Systematic Review Centre for Laboratory Animal Experimentation’s RoB for animal studies.

Results:
A total of 12 studies were included in the review based on the predetermined eligibility criteria, consisting of 4 human and 8 animal model reports. Among the four human studies, two had a low risk, while the other two had some concerns of bias. In the case of eight animal model of asthma, a total of three domains had a high risk of bias. Moreover, the anti-inflammatory properties of apitherapy were demonstrated by its capacity to inhibit NF-κB, nuclear factor of activated T cells, and IgE antibodies, leading to decreased production of tumor necrosis factor-α, interleukin-2 (IL-2), IL-6, and IL-8, and an increase in IL-10 levels. These beneficial effects were reported to be associated with improvements in clinical manifestations and lung function parameters in human subjects. The use of apitherapy was also related to the restoration of airway structure, and reduction of inflammatory cell infiltration, epithelial thickness, and mucus secretion in lung tissue of animal model of asthma.

Conclusion:
Based on the results, apitherapy was effective in improving asthma symptoms and reducing inflammation in human and animal models of asthma.
Seroprevalence of Toxoplasma gondii and Associated Risk Factors among Pregnant Women in Algeria
Authors: Sebaa Soumia , Behnke Jerzy M. , Labed Amina , Abu-Madi Marawan A. 
Published: April 2024

ABSTRACT.
Toxoplasma gondii is an obligate intracellular protozoan parasite affecting all warm-blooded vertebrates, including humans. Infections in humans can lead to severe clinical manifestations in pregnant women and immunocompromised patients. The aim of the present study was to assess seroprevalence of T. gondii infection and to identify the associated risk factors among pregnant women from southern Algeria. A cross-sectional study was conducted from March 2021 to May 2022 among 1,345 pregnant women. A structured questionnaire was used to obtain information on risk factors associated with infection. Participants were screened for anti T. gondii IgG and IgM antibodies using the enzyme-linked fluorescent assay. The overall IgG and IgM seroprevalence was 13.6% and 0.89%, respectively. A significant association was found between seroprevalence of anti T. gondii IgG and history of spontaneous abortion (P = 0.016). Moreover, an increasing trend of seroprevalence was detected in the autumnal season (P = 0.030), and eating raw or undercooked meat was found to be significantly associated with anti–T. gondii IgM seropositivity (P = 0.002). Multivariate analysis showed that women who had experienced spontaneous abortion, regularly ate undercooked meat, and used bottled water in summer were more likely to contract infection with T. gondii. The majority (86.4%) of the studied pregnant women were serologically negative for toxoplasmosis and hence were susceptible to primary acute infection during pregnancy and possible fetal anomalies. Therefore, health education and awareness of the disease and its transmission to women, especially during pregnancy, is imperative.
Deletions of Histidine-Rich Protein 2/3 Genes in Natural Plasmodium falciparum Populations from Cameroon and India: Role of Asymptomatic and Submicroscopic Infections
Authors: Kojom Foko Loick Pradel , Eboumbou Moukoko Carole Else , Jakhan Jahnvi , Narang Geetika , Hawadak Joseph , Kouemo Motse Francine Dorgelesse , Pande Veena , Singh Vineeta 
Published: April 2024

ABSTRACT.
The bulk of malaria rapid diagnostic tests (RDTs) target histidine-rich protein 2 of Plasmodium falciparum, the deadliest malaria species. The WHO considers pfhrp2/3 deletions as one of the main threats to successful malaria control and/or elimination; as such, parasites that lack part or all of the pfhrp2 gene are missed by pfHRP2-targeting RDTs. Such deletions have been reported in several African and Asian countries, but little is known in Cameroon and India. Blood samples were collected from individuals living in four areas of Cameroon (Douala, Maroua, Mayo-Oulo, Pette) and India (Mewat, Raipur, Ranchi, Rourkela). Deletions in pfhrp2/3 genes were confirmed if samples 1) had ≥100 parasites/µL by quantitative polymerase chain reaction (PCR), 2) PCR negative for pfhrp2/3, and 3) PCR positive for at least two single-copy genes. The overall proportion of pfhrp2 and pfhrp3 deletions in Cameroon was 13.5% and 3.1%. In India, the overall proportion was 8% for pfhrp2 and 4% for pfhrp3. The overall proportions of samples with both gene deletions (pfhrp2–/3–) were 3.1% in Cameroon and 1.3% in India. In Cameroon, pfhrp2–/3+ and pfhrp2–/3– deletions were common in Maroua (P = 0.02), in asymptomatic parasitemia (P = 0.006) and submicroscopic parasitemia (P <0.0001). In both countries, pfhrp2/3 deletions, including pfhrp2–/3– deletions, were mainly seen in monoclonal infections. This study outlines that double deletions that result in false negative RDTs are uncommon in our settings, and highlights the importance of active molecular surveillance for pfhrp2/3 deletions in Cameroon and India.
Gordon Matta-Clark entre Arte e Arquitetura: uma questão de espaço, forma e função
Authors: O’Neill Elena 
Published: April 2024

Gordon Matta-Clark se graduou como arquiteto na Cornell University em 1968. Porém, ele institui uma relação particular com a arquitetura: se recusa a construir, embora seu trabalho estabeleça um diálogo entre arte e arquitetura no território da arquitetura; critica e questiona os principais postulados da arquitetura moderna; opera no espaço mediante cortes e alterações nos sistemas de referência que refletem uma atitude crítica frente a sistemas e estruturas sociais, econômicas e culturais. Se as obras estão inseridas num processo histórico com o qual estabelecem um vínculo duplo (ao mesmo tempo em que recebem impulso da cultura, também a modificam), como posicionar-nos frente aos objetos que nos constituem? Em que medida eles estão permeados por idéias e textos de outros? Qual é a dimensão extemporânea dessas idéias e textos? Este artigo se propõe pensar esses diálogos a partir de alguns trabalhos no campo da arte e da arquitetura.
Os Espectadores Performers
Authors: Peled Yiftah 
Published: April 2024

Este artigo elabora conteúdo sobre o tema da incorporação dos espectadores de arte que se tornam performers. Tratam-se de artistas contemporâneos que incluem os visitantes no espaço expositivo, através do uso da fotografia. Ao fazer o registro do ato de observar obras de arte, os artistas usam variados formatos de percepção dos visitantes. Além disso, realiza-se uma tentativa de organizar conceitualmente essa estratégia artística, na qual se pode observar confrontos entre diferentes modelos de performances nas instituições de arte e seus aspectos sociais e temporais, bem como questões que envolvem relações de gênero e voyeurismo.
A Imagem que Representa o Dispositivo que Representa a Imagem
Authors: Garbelotti Raquel 
Published: April 2024

Os textos e as fotografias resultantes dessa pesquisa antropológica constroem uma narrativa ficcional da “tipologia” da casa pomerana. A pesquisa acadêmica se definiu como um site de intervenção artística apresentando a (in)capacidade do texto e da imagem de produzirem um “conhecimento” desta comunidade. Tanto as alunas pomeranas quanto os alunos de iniciação científica trabalharam como colaboradores, produzindo aspectos relacionais e consciência de novas escalas de colaboração enquanto projeto relacional.
Motivações Coincidentes entre Artes e Ciências
Authors: Paz Gaspar 
Published: April 2024

Neste ensaio, abordaremos algumas das aproximações entre o meio artístico e as ciências a partir das interpretações de Gerd Bornheim. Nesse viés, são exemplares as poéticas de Brecht e de Beckett, na medida em que as inflexões de seus trabalhos revelam um intenso diálogo entre as artes e as ciências. Bornheim compreendeu a extensão dessa temática até nossos dias, por meio da dinâmica das linguagens artísticas, da critica à normatividade, do redimensionamento político da vida cotidiana e dos desenvolvimentos científicos e tecnológicos. São as verberações da criatividade que se intensificam cada vez mais nessas áreas.
Paisagem: entre o Mundo e a Cultura
Authors: Barreto Waldir 
Published: April 2024

Paisagem não é um conceito universal, mas corresponde a uma etimologia e uma história semântica singular e moderna, sendo o resultado de uma construção intelectual, subjetiva, cuja primeira palavra conhecida surge na China do século IV. Formatos latinos e nórdicos surgem paralelos por volta do trecento, significando o esforço de resumir numa única expressão o sentimento da natureza percebida sinteticamente no tempo e no espaço. Somente com a invenção da paisagem sonora esta sinestesia foi admitida. A partir das experiências futuristas até as pesquisas com as músicas concreta e acusmática, a proposição da paisagem sonora constitui ainda uma etapa para uma epistemologia pós-moderna do conceito de paisagem.
Expressões/Atitude
Authors: Silva João Castro 
Published: April 2024

Através de uma pontual revisão bibliográfica, este texto apresenta uma rede de pensamentos, estendidos sobre o conceito de fisiognomonia [de physis (natureza) e gnomon (interpretação), significa reconhecimento, interpretação da natureza]. No interior desse interesse, algumas perguntas são trabalhadas diretamente: Como fixar formas inteligíveis quando o próprio corpo, e o rosto em particular, é o mais delusório de todos os objectos? Como explicar a inefabilidade de uma emoção, ou a subtil nuance de uma forma, numa expressão que no mesmo momento em que se torna perceptível, aos nossos olhos, já se desvaneceu?
La réception de l’art à l’ère du post-art
Authors: Chateau Dominique 
Published: April 2024

Que sont les valeurs de l’art devenues à l’ère du post-art ? Peut-on envisager leur remplacement définitif par des « valeurs du post-art » ? Mais le mot post-art désigne, par son préfixe, un moment après l’art qui n’est pas encore absolument émancipé de l’art. L’écart du post-art vis-à-vis de l’art est son écart à partir de l’art. En même temps, si les valeurs du post-art sont encore les valeurs de l’art, c’est dans un contexte idéologique où la valeur de l’art en général est désormais tenue pour désuète, voire aliénante. On ne peut croire ni à l’idée d’une substitution radicale de valeurs qu’on trouve dans certains discours, ni à l’idée contraire que cette substitution n’est qu’une illusion du discours. Le passage au post-art est réel, pour le meilleur et pour le pire, comme fut l’art… En même temps, il reste en devenir, inachevé, en souffrance, en sorte que, dans la systémique de son dysfonctionnement, les valeurs de l’art et celles du post-art sont en constante tension, formant une sorte d’« image dialectique », au sens de Benjamin. [...][1]. Dys- : en souffrance…
O Mesmo: Variações Tautológicas e Políticas
Authors: Oliveira Silfarlem 
Published: April 2024

Apresentando o volume mesmo, parte da pesquisa mesmo, abordamos, neste relato, a exposição “January 5-31” (1969), cujo organizador Seth Siegelaub, juntamente com os artistas, assume o catálogo como “informação primária” (o comentário como obra) e a mostra “Hacia un perfil del arte latinoamericano” (1972) e “Arte conceptual frente al problema latinoamericano” (1974) do Grupo delos Trece, organizada por Jorge Glusberg, que igualmente, em chave ideológica, assume os meios impressos como espaço de visibilidade e exposição.
Formação Artística, Percepção Semiótica e o Signo Simbólico.
Authors: Dos Santos Romilson Marco 
Published: April 2024

Este trabalho visa a discutir em que medida o signo simbólico sucumbe à percepção do artista, no que tange à captura e subversão das mediações contidas nas práticas sociais. Supomos, com efeito, que o hábito adquirido de todo signo simbólico compromete a transgressão de uma realidade fabricada e, de tal modo, que- para promover essa transgressão - o artista necessita de um olhar fenomenológico, o qual é obstruído por aquele signo. Portanto, concentrar-nos-emos na falência artística intervencionista do artista, o qual fica submisso ao signo simbólico. De imediato, fica evidente que o signo simbólico engendra uma opacidade para aquilo que é real. Evidencia-se, portanto, a importância do conceito de percepção e do pragmaticismo de C.S. Peirce no que tange à busca por romper a opacidade imposta pelo signo simbólico.
PENERAPAN E-MODUL BERBANTUAN GEOGEBRA UNTUK MENINGKATKAN HASIL BELAJAR KALKULUS INTEGRAL LIPAT
Authors: Meilasari Venty 
Published: April 2024

Abstract: This research aims to improve learning outcomes of folding integral calculus. This research is Action Research. In one action cycle there are four stages, namely planning, implementing, observing, and reflecting. The research subjects were students in the fifth semester of the 2021/2022 academic year, the Mathematics Education Study Program, FKIP UMKO. The instruments in this study were tests, validation questionnaires, and observation sheets. The research was conducted in two cycles. Cycle 1 was declared not successful, because only 34% of students had achieved the target set. After making improvements based on the reflection results of cycle 1, cycle 2 was carried out. In cycle 2, it was found that 72% of students had achieved the set targets.

Keywords: e-module, geogebra, folding integral calculus
Pengaruh Model Pembelajaran Needham terhadap Pemahaman Konsep Trigonometri
Authors: Meilasari Venty , Handayani Ratih , Refiasari Mira 
Published: April 2024

Abstract: The purpose of this study was to determine whether the Needham learning model had a positive effect on students' understanding of trigonometric concepts. The research methods used are experimental and the study design used is quasi-experimental involving only post-tests. The study population consisted exclusively of students in Class X of Madrasah Aliya Al-Mubarok for the 2021/2022 school year. The samples in this study were classes X IPA 1 and X IPA 2 drawn using a cluster random sampling technique. Correct t-test statistics were used for data analysis. Based on the results of data analysis obtained 3.617 and 1,678. Based on these results, obtained , it can be concluded that there is a positive effect of the application of the Needhaam learning model on students' understanding of concepts.

Keywords: Needham Learning Model; Concept Understanding; Trigonometry
PENGARUH PEMBERIAN KOMBINASI SHORT WAVE DIATHERMY DAN STRETCHING HAMSTRING TERHADAP PENINGKATAN KEMAMPUAN FUNGSIONAL PADA PASIEN OSTEOARTHRITIS KNEE UNILATERAL
Authors: Rahayuningsih Apriana , Hargiani Fransisca Xaferia , Kasimbara Rachma Putri , Halimah Nurul 
Published: April 2024

Pendahuluan: Osteoarthritis knee merupakan penyakit degenerative sendi yang menyebabkan mobilitas sendi menjadi terbatas. Akibat keterbatasan mobilitas sendi dapat menyebabkan menurunnya kemampuan fungsional knee. Stretching hamstring merupakan bentuk latihan yang bertujuan mengulur atau meregangkan otot yang mengalami penurunan elastisitas dan fleksibilitas sehingga mengurangi keterbatasan lingkup gerak sendi lutut untuk memperbaiki pola jalan sehingga dapat meningkatkan kemampuan fungsional knee. Tujuan penelitian ini untuk mengetahui pengaruh pemberian kombinasi short wave diathermy dan stretching hamstring terhadap peningkatan kemampuan fungsional pada pasien osteoarthritis knee unilateral. Metode: Jenis penelitian ini menggunakan quasi eksperimen dengan metode one group pretest dan posttest design. Dengan sampel 30 orang yang diambil secara acak. Menggunakan alat ukur skala WOMAC dengan desain latihan kombinasi short wave diathermy dan stretching hamstring diberikan sebanyak 2 kali seminggu selama satu bulan. Hasil: Uji hipotesis wilcoxon diperoleh nilai median pre 47.00 dan post 44.00 dengan selisih 3.00 dan nilai p=0.000 (p<0.05). Kesimpulan: Terdapat pengaruh pemberian kombinasi short wave diathermy dan stretching hamstring selama 8 kali perlakuan terhadap peningkatan fungsional pada kondisi osteoarthritis knee unilateral.
Kata kunci: osteoarthritis knee, short wave diathermy, streching hamstring