bluuebunny/crossref_metadata_2025_split huggingface dataset:
Morphological state of lungs of rats under the influence of Vipera berus berus venom
Authors: Lasavutz V. S. , Yaremenko L. M. , Butska L. V. , Lavrynenko V. Y. , Zhehulovych Z. Y. 
Published: June 2024

About 5.4 million snake bite cases are registered worldwide every year. About half of them cause 81,000-138,000 deaths or disabled 400,000 people. Despite this, this problem is neglected in many countries in Asia, Africa and Latin America. It is believed that death from snakebites is associated with poverty since the lack of proper access to medical facilities in such sections of the population causes the development of fatal complications. The purpose of the study is to study the morphological state of rats' lungs under exposure to Vipera berus berus venom. Experimental studies were carried out on white, non-linear male rats. Animals were conditionally divided into control and experimental groups, ten individuals each. Experimental rats were injected intraperitoneally with a semi-lethal dose (LD50) (1.576 mg/g-1) of Vipera berus berus venom in a physiological solution. Animals of the control group were injected intraperitoneally with only a physiological solution. Rats were removed from the experiment 24 hours after exposure to the poison and anaesthetized by cervical dislocation. Lung tissue samples were taken for microscopic examination. Fixation of the material and preparation of paraffin blocks were carried out according to generally accepted methods. Staining of histological preparations of the lungs was carried out with hematoxylin and eosin, according to Masson, and the PAS+"Hale" reaction was carried out according to the Mowry method. Histological preparations were studied using an SEO SСAN light microscope. The toxic effect of Vipera berus berus venom caused significant changes in the vascular, stromal and parenchymal components, which was confirmed by histological, histochemical and morphometric data. In the lungs of experimental animals, the vascular bed is primarily restructured, forming coagulopathies and thrombosis. The development of DIC syndrome and haemorrhages accompanies an increase in the permeability of the vessel wall. Inflammatory phenomena are found in the bronchi and respiratory departments' walls. There is a remodelling of the respiratory department components, with the formation of significant areas of dis- and atelectasis and zones of emphysema, which is confirmed morphometrically.
ENSINO-APRENDIZAGEM DE INGLÊS COM USO DAS TECNOLOGIAS DIGITAIS NO CONTEXTO AMAZÔNICO
Authors: João Jeisiano Salvador Fernandes  
Published: June 2024

Este estudo de estado da questão objetivou analisar artigos e dissertações que tratam do processo de ensino-aprendizagem de inglês por meio das tecnologias digitais da informação e comunicação (TDIC), destacando a sua aplicabilidade considerando o contexto amazônico. Para compor a amostra a ser analisada, foram selecionados trabalhos publicados a partir de 2015 até 2021, no total de dezesseis (16) publicações, sendo dez (10) artigos cinco (5) dissertações e uma (1) monografia de especialização lato sensu. Com relação à metodologia, trata-se de um estudo qualitativo caracterizando-se como uma revisão de literatura. As bases de dados usadas para fazer esse levantamento foram o Google Acadêmico e o Catálogo de Teses e Dissertações Capes. Para a escolha das publicações, três pares de descritores foram usados: “TDIC” and “contexto amazônico”; “ensino-aprendizagem” and “Língua Inglesa” e “TDIC” and “Língua Inglesa”. Os resultados nos mostram que o uso das TDIC auxilia de maneira positiva no processo de ensino-aprendizagem de inglês, possibilitando que o professor venha a refletir sobre as potencialidades e a apropriação dessas tecnologias para fins pedagógicos. Porém, destaca que ainda é necessário realizar mais pesquisas para aprofundar o estudo sobre currículo com base no contexto no qual os alunos e professores estão inseridos.
Palavras-chave: TDIC; Inglês; Ensino-aprendizagem; Contexto Amazônico.
CARACTERIZAÇÃO MORFOAGRONOMICA DE 14 ACESSOS DE MILHO TRADICIONAL DA REGIÃO DO ALTO SOLIMÕES, AMAZONAS
Authors: Lima de Souza Diones , Fernandes da Silva Filho Danilo , Felipe de Oliveira Gentil Daniel 
Published: June 2024

O presente trabalho teve por objetivo avaliar e caracterizar variedades tradicionais de milho cultivadas por agricultores familiares da região do Alto Solimões, Amazonas. As amostras foram constituídas por sementes obtidas de plantas cultivadas por agricultores familiares do município de Benjamin Constant, Amazonas, totalizando 14 acessos de milho, oito variedades. A caracterização das variedades foi feitas de acordo com 42 descritores quali-quantitativos indicados pelo Internacional Plant Genetic Resources Institute - IPGRI (2000) e Teixeira e Costa (2010). Foi feita a análise de variância das características e complementada pelo teste de t (Studant), em nível de 5% de probabilidade, utilizando o programa computacional Genes. Os resultados revelaram a existência de variabilidade genética entre os 14 acessos avaliados, considerando os descritores associados à planta, à espiga e ao grão. Foi constatado a partir da avaliação de 32 descritores da espécies, que as práticas de manejo empregadas pelos agricultores locais tem sido eficientes na manutenção de caracteres importantes, capazes de representar aspectos morfoagronômicos próprios dos acessos oriundos da Região do Alto Solimões. Portanto conclui-se que a caracterização morfoagronômica utilizadas neste estudo foi capaz de determinar a existência de variabilidade e caracteres importantes entre os acessos de milho do Alto Solimões.
Sub-Saharan African experience of neurosurgical oncology care: challenges and barriers encountered at 7 cancer treatment centers
Authors: Ashagere Yordanos , Shabani Hamisi K. , Labuschagne Jason , Copeland William , Nketiah-Boakye Frank , Sichizya Kachinga , Ahmad Misbahu Haruna , Gurara Addisalem Belete , Schroeder Kristin , Chotai Silky , Haizel-Cobbina Joseline , Dewan Michael C. 
Published: June 2024

OBJECTIVE
Wide disparities in neurosurgical oncology care and treatment outcomes exist globally despite recent improvements in diagnostics and cancer therapy. To better understand the challenges to neurosurgical oncology care in low-resource settings, the authors collected data on national neurosurgical capacity and hospital diagnostic and treatment capacity across 7 national referral hospitals in 7 countries in sub-Saharan Africa (SSA).

METHODS
In April 2023, a 42-item self-administered questionnaire was distributed to partner neurosurgeons at the 7 centers via REDCap to provide country- and hospital-level capacity data on neurosurgical oncology care.

RESULTS
Neurosurgical and neurosurgical oncology care were reported to be available in a limited number of provinces, states, regions, and counties in 6 of the 7 countries. The general neurosurgical workforce density across the 7 countries ranged from 0.03 to 0.67 per 100,000 persons, and that of the pediatric neurosurgical workforce ranged from 0 to 0.05 per 100,000 persons. Two centers had no pediatric ICUs, and the remaining 5 centers had pediatric ICUs with bed capacities between 1 and 8. One hospital had neither a CT nor an MRI scanner available and relied solely on private diagnostic facilities for neuroimaging. Histopathology services were largely limited to basic histopathology staining only; molecular subtyping was available at a single center. Three hospitals offered pediatric anesthesia expertise. None of the hospitals offered subspecialty neuro-oncology care or had a pediatric neuro-oncologist. None of the 7 hospitals had formal neurocritical care, neuroradiology, or neuropathology expertise. Neither adjuvant chemotherapy nor radiotherapy was available at 3 centers. Rehabilitation was largely limited to basic physical and occupational therapy at all 7 centers. Although all 7 countries had a multiple health payer system, the payment structure differed across the 7 hospitals for different neurosurgical oncology services, with patients making out-of-pocket payments for all services in some cases.

CONCLUSIONS
There are significant challenges to timely and quality neurosurgical oncology care in SSA especially for children. System-level interventions are needed to strengthen neurosurgical oncology care capacity in SSA.
Fluoroscopic sniff test as a diagnostic tool for phrenic nerve injury in patients with traumatic brachial plexus injury
Authors: Watanapokasin Pasin , Monteerarat Yuwarat , Ongsiriporn Mathee , Limthongthang Roongsak , Vathana Torpon , Laohaprasitiporn Panai 
Published: June 2024

OBJECTIVE
Traumatic brachial plexus injury (BPI) is a high-morbidity condition with an escalating incidence. One of the treatment options is neurotization using the ipsilateral phrenic nerve. Therefore, diagnosis of nerve dysfunction is a crucial step in preoperative planning. This study aimed to assess the accuracy and reliability of the fluoroscopic sniff test for preoperative diagnosis of phrenic nerve injury in patients with traumatic BPI.

METHODS
The study was conducted from June 2019 to August 2023 at a tertiary care hospital. A preoperative fluoroscopic sniff test was performed. During brachial plexus surgery, direct phrenic nerve stimulation was conducted as a gold standard of phrenic nerve function. Two nonoperating orthopedic surgeons interpreted the accuracy and reliability of the test.

RESULTS
Seventy-four patients with traumatic BPI (66 males and 8 females) with a median age of 26 years were enrolled. Sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of the fluoroscopic sniff test were 90.9% (95% CI 75.7%−98.1%), 100% (95% CI 91.4%−100%), 100% (95% CI 88.4%−100%), 93.2% (95% CI 82.3%−97.6%), and 95.9% (95% CI 88.6%−99.2%), respectively. Interobserver reliability showed excellent agreement (κ = 1, p < 0.001).

CONCLUSIONS
The fluoroscopic sniff test was proven to be an accurate, reliable, and simple tool to evaluate phrenic nerve function in patients with traumatic BPI. Preoperative testing should be performed to reduce operative time to identify the phrenic nerve as a donor for nerve transfer surgery in cases in which no function is detected from the fluoroscopic sniff test.
Characteristics of radiation-induced brain tumors: case series and systematic review
Authors: Onishi Shumpei , Yamasaki Fumiyuki , Kinoshita Yasuyuki , Amatya Vishwa Jeet , Yonezawa Ushio , Taguchi Akira , Ozono Iori , Maeda Yugo , Khairunnisa Novita Ikbar , Go Yukari , Takeshima Yukio , Horie Nobutaka 
Published: June 2024

OBJECTIVE
Radiation therapy (RT) improves the outcome of patients with cancer but introduces the risk of radiation-induced neoplasms in cancer survivors. The most common radiation-induced brain tumors (RIBTs) are gliomas (RIGs), meningiomas (RIMs), and sarcomas (RISs). To investigate the characteristics of these RIBTs, the authors conducted a comprehensive review and analysis of their case series and relevant cases from the literature.

METHODS
Sixteen patients in the case series and 941 patients from the literature who previously underwent cranial irradiation were included in this study. The age at irradiation for primary disease was recorded, and the latency period from irradiation to the development of RIBT and the median overall survival (OS) of patients with RIBTs were analyzed using the Kaplan-Meier method. Patients were stratified by age at the time of irradiation (pediatric vs nonpediatric) and the irradiation dose (higher vs lower dose), and latency and OS were compared using the log-rank test.

RESULTS
Among patients with RIBTs, 23.4% underwent radiation at < 5 years of age, and 46.6% underwent RT in the 1st decade of life. The median ages at cranial irradiation were 8.4 (IQR 4.1–16) years in patients with RIMs, 9 (IQR 5–23) years in patients with RIGs, and 27.7 (IQR 13.8–40) years in patients with RISs. The median latency period from irradiation to the development of RIM was significantly longer than that to the development of RIG and RIS (RIM: 20 years, RIG: 9 years, RIS: 10 years; p < 0.0001). The latency period was shorter in the nonpediatric patient group with RIMs (p = 0.047). The OS was significantly longer in patients with RIMs than in those with RIGs and RISs (RIM: not reached, RIG: 11 months, RIS: 11 months; p < 0.0001). The OS of patients with RIMs and RIGs was significantly shorter in patients who received higher radiation doses (p = 0.0095 and p = 0.0026, respectively).

CONCLUSIONS
The prognosis was poor and worse for patients with RIGs and RISs than for those with RIMs, and patients with RIBTs who underwent higher-dose irradiation for primary disease had poor prognoses. Because RIBTs develop more than a decade after cranial irradiation, long-term follow-up is crucial.
Importance of the lumbar paraspinal muscles on the maintenance of global sagittal alignment after lumbar pedicle subtraction osteotomy
Authors: Caffard Thomas , Arzani Artine , Amoroso Krizia , Chiapparelli Erika , Medina Samuel J. , Schönnagel Lukas , Zhu Jiaqi , Verna Bruno , Finos Kyle , Nathoo Isaac , Tani Soji , Camino-Willhuber Gaston , Guven Ali E. , Zadeh Arman , Tan Ek Tsoon , Carrino John A. , Shue Jennifer , Dobrindt Oliver , Zippelius Timo , Dalton David , Sama Andrew A. , Girardi Federico P. , Cammisa Frank P. , Hughes Alexander P. 
Published: June 2024

OBJECTIVE
There are limited data about the influence of the lumbar paraspinal muscles on the maintenance of sagittal alignment after pedicle subtraction osteotomy (PSO) and the risk factors for sagittal realignment failure. The authors aimed to investigate the influence of preoperative lumbar paraspinal muscle quality on the postoperative maintenance of sagittal alignment after lumbar PSO.

METHODS
Patients who underwent lumbar PSO with preoperative lumbar MRI and pre- and postoperative whole-spine radiography in the standing position were included. Spinopelvic measurements included pelvic incidence, sacral slope, pelvic tilt, L1–S1 lordosis, T4–12 thoracic kyphosis, spinosacral angle, C7–S1 sagittal vertical axis (SVA), T1 pelvic angle, and mismatch between pelvic incidence and L1–S1 lordosis. Validated custom software was used to calculate the percent fat infiltration (FI) of the psoas major, as well as the erector spinae and multifidus (MF). A multivariable linear mixed model was applied to further examine the association between MF FI and the postoperative progression of SVA over time, accounting for repeated measures over time that were adjusted for age, sex, BMI, and length of follow-up.

RESULTS
Seventy-seven patients were recruited. The authors’ results demonstrated significant correlations between MF FI and the maintenance of corrected sagittal alignment after PSO. After adjustment for the aforementioned parameters, the model showed that the MF FI was significantly associated with the postoperative progression of positive SVA over time. A 1% increase from the preoperatively assessed total MF FI was correlated with an increase of 0.92 mm in SVA postoperatively (95% CI 0.42–1.41, p < 0.0001).

CONCLUSIONS
This study included a large patient cohort with midterm follow-up after PSO and emphasized the importance of the lumbar paraspinal muscles in the maintenance of sagittal alignment correction. Surgeons should assess the quality of the MF preoperatively in patients undergoing PSO to identify patients with severe FI, as they may be at higher risk for sagittal decompensation.
Spinal neurenteric cysts: experience with 9 cases via an anterior cervical approach
Authors: Xin Zong , Du Yueqi , Zhang Can , Zhang Boyan , Qi Maoyang , Meng Hongfeng , Jin Tianyu , Chan Chee Kong , Chen Zan , Duan Wanru 
Published: June 2024

OBJECTIVE
Intraspinal cysts are uncommon, and the success rate of complete resection is still low for spinal neurenteric cysts (NCs). The aim of this study was to evaluate the efficacies of an anterior microscopic surgical approach in the treatment of ventral and ventrolateral subaxial cervical NCs (SCNCs).

METHODS
Between 2019 and 2022, 9 patients with NCs of the subaxial spine underwent an anterior microsurgical approach. Their clinical presentations, radiological features, operative findings, and follow-up data were retrospectively reviewed and analyzed.

RESULTS
All spinal cysts were intradural and extramedullary in origin. Five patients were first-time cases while 4 patients with recurrence underwent revision surgery. The most common clinical manifestation was pain (77.78%). One patient was found to have a concomitant disorder of Klippel-Feil syndrome. Microscopically confirmed gross-total resection was achieved in 8 patients (88.89%) based on clinical comparisons between pre- and postoperative MRI and intraoperative video. One patient had symptom recurrence 1 year after subtotal resection, while there was no evidence of recurrence during follow-up for the other patients. Dense adhesions within the spinal cord were observed in 8 patients (88.89%) intraoperatively. Most importantly, the surgical outcome was significantly improved in all patients, and the mean (± SE) Japanese Orthopaedic Association score increased from 11.33 ± 0.91 preoperatively to 16.22 ± 0.32 postoperatively (p = 0.008).

CONCLUSIONS
An anterior surgical approach was proven to be both safe and effective in treating the ventral or ventrolateral SCNCs. The authors believe that an anterior microsurgical approach should be considered as a useful approach especially in patients with ventral recurrent SCNCs. Its clinical efficacy compared with a posterior approach in ventral spinal cyst may be better as most of the neurenteric cysts are ventrally or ventrolaterally located.
Improvement in autonomic balance through 12-week supplementation of a novel curcumin formulation in healthy Japanese adults: A randomized, placebo-controlled study
Authors: Yoshitaka Kuwabara , Lee Hyunjin , Hirose Akiko , Makino Yuji , Hashimoto Kyohei , Sakata Misaki , Watanabe Tadashi 
Published: June 2024

Background: Curcumin has several health benefits due to its potent antioxidant and anti-inflammatory properties,
but its bioavailability is very low, limiting its potential. We have developed a novel curcumin formulation, TS-P1, which
has an 85.2-fold higher bioavailability of curcumin than raw curcumin.

Objective: To investigate the efficacy of TS-P1 on fatigue, mood status, and autonomic function.

Methods: Ninety healthy Japanese adults were randomized to the placebo or TS-P1 group and took either the placebo
or TS-P1 containing 150 mg of curcumin for 12 weeks. Visual Analogue Scale for Fatigue (VAS-F) scores, Profile of
Mood States Questionnaire second edition (POMS2) scores, and autonomic functions were measured every 4 weeks.

Results: Both groups showed an improvement in the VAS-F over the study period, but there was no significant
difference between the placebo and TS-P1 groups. However, the mean change from baseline in the anger and
depression scores of the POMS2, particularly in those aged 40 and over, in the TS-P1 group showed a greater range
of decline at week 12. The mean change from baseline in LnLF and LF/HF also decreased in the TS-P1 group. Blood
pressure also decreased in the TS-P1 group.

Conclusions: These data suggest that TS-P1 induced a parasympathetic dominant state, and that curcumin has an
important role in the regulation of autonomic balance. 12 weeks of supplementation of TS-P1 is expected to improve
both mood status and vascular function.

Trial registration: UMIN000050377

Foundation: Theravalues Corporation

Keywords: curcumin; TS-P1: Theracurmin Super; mood status; autonomic balance, parasympathetic dominance;
vascular function
Effect of training phased distance training method the archer's shooting ability
Authors: Dwijawanti Betaria , Satria M. Haris 
Published: June 2024

This study aims to evaluate the effect of gradual distance drill method training on the shooting ability of archery athletes at Dega Archery School. The research methods used were pre-experimental research methods with the design of a group pre-test and post-test design. The study sample consisted of 10 athletes selected based on a uniform ability level. Instrumental research using an archery accuracy test. Data analysis using paired t-test with SPSS version 23. The results showed a significant improvement in accuracy and consistency of shooting in the athletes who underwent the gradual distance drill method, indicating the method's effectiveness in improving shooting ability. This finding highlights the potential of the Gradual Distance Drill Method as a training strategy that can be used to enhance the performance of archery athletes. Conclusion The graded distance drill method can be used as a training strategy to improve the performance of archery athletes. Suggestions, further research could use larger sample sizes and tighter controls to provide an understanding of the effectiveness of the method in a broader context.
SISTEM INFORMASI PERPUSTAKAAN PADA SMA NEGERI JAYALOKA BERBASIS WEB DAN BARCODE SCANNER
Authors: Irawan Davit , Intan Bunga , Astuti Endang Tri 
Published: June 2024

Pada penelitian ini di ketahui bahwa perpustakaan SMAN Jayaloka memiliki permasalahan yaitu pada proses peminjaman dan pengembalian buku yang dimana pada prosesnya masih dilakukan secara manual dengan cara pencatatan sehingga pada prosesnya akan membutuhkan waktu yang cukup lama dalam pengolahan data-data tersebut. Hasil dari penelitian menunjukkan bahwa program sistem informasi perpustakaan pada SMA Negeri Jayaloka berbasis web mobile dan barcode scanner merupakan suatu sistem informasi yang dapat membantu dalam proses perminjaman dan pengembalian buku dan pembuatan laporan, dan dalam pembuatan sistem menggunakan bahasa pemograman PHP dan database MySQL serta Notepad++ dalam penulisan code program. Kesimpulan dalam penelitian ini adalah bahwa sistem informasi perpustakaan pada SMA NegerI Jayaloka berbasis web mobile dan barcode scanner dapat membantu agar dalam proses peminjaman dan pengembalian tidak memakan waktu yang lama dan dapat mendapatkan hasil yang akurat serta cepat.
PREDIKSI JUMLAH PENGANGGURAN PROVINDI RIAU DENGAN MENGGUNAKAN METODE (SMA, WMA, EMA)
Authors: Ardana Yudha , Fadli Waris Khair , Faidi Zulfaidi 
Published: June 2024

Masalah pengangguran merupakan salah satu masalah utama dalam bidang ekonomi yang sampai saat ini masih menjadi penghambat dalam hal pembangunan daerah. Karena masalah pengangguran ini akan menimbulkan masalah-masalah sosial lainya. Studi ini bertujuan untuk meramalkan jumlah pengangguran di Provinsi Riau dengan menerapkan metode peramalan, yaitu single moving average, weighted moving average, dan exponential moving average. Data historis pengangguran digunakan untuk mengidentifikasi tren dan pola, sementara ketiga metode peramalan diaplikasikan untuk memprediksi jumlah pengangguran di masa depan. Analisis perbandingan kinerja ketiga metode dilakukan untuk menentukan metode mana yang paling akurat dalam mengantisipasi fluktuasi pengangguran di wilayah tersebut. Dari hasil penelitian ini diharapkan dapat memberikan kontribusi pada pemahaman pergerakan pasar tenaga kerja di Provinsi Riau serta menjadi landasan kebijakan yang lebih efektif dalam mengatasi isu pengangguran. Di tinjau dari hasil penelitian yang kamu telah lakukan di peroleh akurasi hasil peramalan yang di nilai lebih akurat di bandingkan dengan metode lainnya yaitu dengan menggunakan metode single moving avarage dengan priode n=2.