bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantitative bone histomorphometry and circulating t lymphocyte subsets in postmenopausal osteoporosis
Authors: Imai Yasuo , Tsunenari Tohru , Fukase Masaaki , Fujita Takuo 
Published: February 2010

Abstract
To explore the influence of the immune system on the development of osteoporosis, 19 untreated postmenopausal women with osteoporosis were studied by means of quantitative histomorphometry of the ilium and an analysis of T lymphocyte subsets in the peripheral blood. Osteoporotic women had lower OKT3+ and OKT8+ counts and a higher OKT4+/OKT8+ ratio than nonosteoporotic control subjects. Linear regression analyses disclosed that the age of subjects correlated with bone mineral density (BMD; r = −0.634, p &lt; 0.01) and some of the histomorphometric parameters for bone formation (r = −0.694 to −0.467, p &lt; 0.010.05). The number of OKT4+ cells showed weak but significant negative correlation with the parameters for bone resorption (r = −0.549 to −0.462, p &lt; 0.05). In a multiple regression analysis, the advanced age, the increase in OKT3+, and the decrease in OKT4+ and OKT8+ counts were shown to be significant predictors for the decrease in BMD (R = 0.882, p &lt;0.01). According to the regression formula obtained from the analysis, the parameters for bone formation were related only to the age of subjects whereas those for bone resorption were tightly associated with the number of OKT4+ and OKT8+ cells but not with the age of subjects. These results indicated that, in addition to the age factor, abnormalities of the peripheral T lymphocyte subsets, especially those of OKT4+ and OKT8+ cells, are closely associated with the decrease in bone mass in postmenopausal osteoporosis, supporting the causal relationship between T lymphocyte functions and the development of postmenopausal osteoporosis.
Inositol trisphosphate receptor gene expression and hormonal regulation in osteoblast-like cell lines and primary osteoblastic cell cultures
Authors: Kirkwood Keith L. , Dziak Rosemary , Bradford Peter G. 
Published: February 2010

AbstractThe inositol trisphosphate receptor (IP3R) is an intracellular calcium channel that mediates the cellular actions of a wide variety of hormones, growth factors, and cytokines. In osteoblastic cell cultures, many bone resorbing hormones increase phosphoinositide turnover, inositol trisphosphate production, mobilization of intracellular calcium, and the secretion of osteoclast recruitment and activating factors. In this study, the effects of 17β-estradiol, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), phorbol ester, and serum on IP3R mRNA levels were evaluated in osteogenic-osteosarcoma cells and in primary osteoblastic cultures derived from neonatal rat calvaria. Type-specific reverse transcription polymerase chain reaction (RT-PCR) indicated that all cell types evaluated (G-292, U-2 OS, Saos-2, MC3T3-E1, UMR-106, and calvarial osteoblastic cells) express IP3R mRNA type I; G-292, U-2 OS, MC3T3-E1, and calvarial osteoblastic cells also express type II IP3R mRNA; and UMR-106 and the calvarial osteoblastic cells express type III IP3R mRNA. Northern blot and RT-PCR analyses of human G-292 osteosarcoma cells and rat calvarial osteoblastic cells showed that phorbol ester and serum increase IP3R mRNA levels, whereas 17β-estradiol and 1,25(OH)2D3 decrease these levels. In G-292 cells, the effect of 17β-estradiol was not due to accelerated IP3R mRNA degradation and required continued protein synthesis. The results show that multiple IP3R types are expressed in osteoblasts and osteoblastic osteosarcoma cells and that this expression is regulated by 17β-estradiol and other osteoporotic and antiosteoporotic hormones. These findings indicate that hormonal control of IP3R expression may be relevant in the chronic regulation of osteoblast secretory activity.
Aligning technology with strategic performance measurement
Authors: Richtermeyer Sandra B. , Webb Shelly E. 
Published: February 2010

AbstractAs controllers and CFOs try to improve the quality of information they provide to decision makers, the one key challenge often is getting the technology support for their needs. This can be particularly true as they develop more strategic information. This article describes the processes that accounting professionals commonly experience as they work to capture more strategic information. It also gives tips for effective technology enablement in the accounting and finance function. © 2010 Wiley Periodicals, Inc.
Pronounced non‐Fermi‐liquid behavior of the quantum critical heavy fermion superconductor β‐YbAlB4
Authors: Nakatsuji Satoru , Kuga Kentaro , Tomita Takahiro , Matsumoto Yosuke 
Published: February 2010

AbstractQuantum criticality has been a central subject in the study of heavy fermion systems, partly because of the emergence of non‐trivial collective phenomena near criticality such as unconventional superconductivity and non‐Fermi‐liquid behavior. While a number of heavy fermion systems have been studied in Ce(4f1) based compounds, examples of quantum critical materials are still scarce in their hole analogs, namely Yb(4f13) based heavy fermion systems. Here we review the low temperature transport and thermodynamic properties hitherto found for the Yb based heavy fermion superconductor β‐YbAlB4 $(T_{\rm c} = 80\,{\rm mK})$. The observations indicate that it provides a rare example of a pure metal that displays quantum critical behavior at ambient pressure and under zero applied magnetic field.
Bayesian adaptive nearest neighbor
Authors: Guo Ruixin , Chakraborty Sounak 
Published: February 2010

AbstractTheknearest neighbor classification (k‐NN) is a very simple and popular method for classification. However, it suffers from a major drawback, it assumes constant local class posterior probability. It is also highly dependent on and sensitive to the choice of the number of neighborsk. In addition, it severely lacks the desired probabilistic formulation. In this article, we propose a Bayesian adaptive nearest neighbor method (BANN) that can adaptively select the shape of the neighborhood and the number of neighborsk. The shape of the neighborhood is automatically selected according to the concentration of the data around each query point with the help of discriminants. The neighborhood size is not predetermined and is kept free using a prior distribution. Thus, we are able to make the model to select the appropriate neighborhood size. The model is fitted using Markov Chain Monte Carlo (MCMC), so we are not using exactly one neighborhood size but a mixture ofk. Our BANN model is highly flexible, determining any local pattern in the data‐generating process, and adapting it to give an improved prediction. We have applied our model on four simulated data sets with special structures and five real‐life benchmark data sets. Our proposed BANN method demonstrates substantial improvement overk‐NN and discriminant adaptive nearest neighbor (DANN) in all nine case studies. It also outperforms the probabilistic nearest neighbor (PNN) in most of the data analyses. Copyright © 2010 Wiley Periodicals, Inc. Statistical Analysis and Data Mining 3: 92‐105, 2010
Does sphere volume affect the performance of three‐dimensional power Doppler virtual vascular sampling for predicting malignancy in vascularized solid or cystic‐solid adnexal masses?
Authors: Kudla M. J. , Alcázar J. L. 
Published: February 2010

AbstractObjectiveTo assess whether, when using spherical sampling with Virtual Organ Computer‐Aided Analysis (VOCAL™) for calculating three‐dimensional (3D) power Doppler angiography (PDA) indices, the sphere volume affects performance in the prediction of malignancy in vascularized cystic‐solid or solid adnexal masses.MethodsOne hundred and thirty‐eight women (mean ± SD age, 51.8 ± 14.1 years) diagnosed as having vascularized cystic‐solid or solid adnexal masses on B‐mode and two‐dimensional (2D) power Doppler ultrasound were evaluated by 3D‐PDA prior to surgery. Five women had bilateral masses, giving a total number of 143 masses analyzed. Vascularization was assessed using VOCAL software. 3D‐PDA vascular indices (vascularization index (VI), flow index (FI) and vascularization flow index (VFI)) from the most vascularized area within papillary projections and solid areas were calculated automatically using spherical sampling. Five different volumes of sphere were used (1 cm3, 2 cm3, 3 cm3, 4 cm3 and 5 cm3) in each case. A definitive histological diagnosis was obtained in each case after surgical tumor removal.ResultsOne hundred and seventeen (82%) masses were malignant and 26 (18%) were benign. Morphological evaluation revealed 34 (24%) unilocular solid masses, 49 (34%) multilocular solid masses and 60 (42%) mostly solid masses. The 1‐cm3 sphere could be used in 100% of the cases, the 2‐cm3 sphere could be used in 98.2% of the cases and the 3–5‐cm3 spheres could be used in 97.2% of the cases. The median VI, FI and VFI for all sphere volumes were significantly higher in malignant compared with non‐malignant tumors. Receiver–operating characteristics curve analysis showed that VI and VFI, independently of sphere volume, were better predictors of malignancy than was FI. The best cut‐off values for the 3D‐PDA indices differed depending on sphere volume. VI was significantly more specific than were VFI and FI.ConclusionsSphere volume does not affect the performance of 3D‐PDA. We recommend the use of different cut‐off values for 3D‐PDA indices for discriminating between benign and malignant adnexal masses, depending on the sphere volume used. Use of VI is preferable due to its higher specificity. Copyright © 2010 ISUOG. Published by John Wiley & Sons, Ltd.
Tetra(diisopropylcarbodiimid‐N)‐Beryllium‐bis‐Triiodid und 1,3‐Diisopropyl‐2,4‐bis(isopropylimino)‐1,3‐Diazetidin
Authors: Neumüller Bernhard , Dehnicke Kurt 
Published: February 2010

AbstractTetra(diisopropylcarbodiimide‐N)‐beryllium‐bis‐triiodide, [Be(i‐C3H7–NCN–i‐C3H7)4](I3)2 (1), was prepared from beryllium powder and iodine in diisopropylcarbodiimide suspension to give red single crystals. Compound 1 catalyzes the cyclodimerization of diisopropylcarbodiimide forming 1,3‐diisopropyl‐2,4‐bis(isopropylimino)‐1,3‐diazetidine (2), which can be isolated as colourless single crystals. 1 and 2 were characterized by X‐ray diffration and IR spectroscopy. Compound 1 crystallizes tetragonally in the space group P$\bar4$21c with two formula units per unit cell. Lattice dimensions at 193(2) K: a = b = 1292.2(1), c = 1411.2(2) pm, R1 = 0.0497. The structure of 1 consists of distorted tetrahedral dications [Be(i‐C3H7–NCN–i‐C3H7)4]2+ with site symmetry $\bar4$ and triiodide ions with site symmetry 2. Compound 2: Space group P21/c, Z = 2, lattice dimensions at 100(2) K: a = 935.2(1), b = 795.5(1), c = 1141.0(1) pm, β = 112.54(1)°, R1 = 0.0304. The structure of 2 forms centrosymmetric molecules with symmetry Ci and planar four‐membered C2N2 rings.
Factors affecting aggression in a captive flock of Chilean flamingos (Phoenicopterus chilensis)
Authors: Perdue Bonnie M. , Gaalema Diann E. , Martin Allison L. , Dampier Stephanie M. , Maple Terry L. 
Published: February 2010

AbstractThe influence of pair bond status, age and sex on aggression rates in a flock of 84 captive Chilean flamingos at Zoo Atlanta was examined. Analysis showed no difference between aggression rates of male and female flamingos, but adult flamingos had higher rates of aggression than juveniles. There were also significant differences in aggression depending on pair bond status (single, same‐sex pair, male–female pair or group). Bonded birds were significantly more aggressive than single birds, which is consistent with the concept that unpaired birds are not breeding and do not need to protect pair bonds or eggs. Birds in typical pair bonds (male–female) and atypical pair bonds (same‐sex pairs or groups) exhibited similar rates of aggression. These results contribute to the existing body of research on aggression in captive flamingos. Zoo Biol 30:59–64, 2011. © 2010 Wiley‐Liss, Inc.
Experiences with a Prophylactic Mesh in 93 Consecutive Ostomies
Authors: Jänes Arthur , Cengiz Yucel , Israelsson Leif A. 
Published: February 2010

AbstractBackgroundParastomal hernia may be present in half of patients after one year. A prophylactic low‐weight prosthetic mesh in a sublay position at the index operation reduces the risk of parastomal hernia, without increasing the rate of complications.MaterialBetween April 2003 and November 2006 all patients with an ostomy created at an open laparotomy were followed for at least one year.ResultsA prophylactic mesh was used in 75 of 93 patients. In 9 a prophylactic mesh could not be placed due to scarring after previous surgery. In 9 a mesh was omitted after surgeon’s decision. In 19 patients a mesh was used in severely contaminated wounds. With a mesh 6 of 73 (8%) patients developed a surgical site infection and without a mesh 4 of 15 (27%). With a mesh parastomal hernia was present in 8 of 61 (13%) patients and without a mesh in 8 of 12 (67%).ConclusionsCreating a stoma in routine open surgery a prophylactic mesh can be placed in most patients. A mesh does not increase the rate of complications and can be used in severely contaminated wounds.
Combined hyperlipidemia in patients with lysinuric protein intolerance
Authors: Tanner Laura M. , Niinikoski Harri , Näntö‐Salonen Kirsti , Simell Olli 
Published: February 2010

AbstractBackground and aimsLysinuric protein intolerance (LPI) is an autosomal recessive disorder characterized by defective transport of cationic amino acids lysine, arginine, and ornithine. Low plasma concentrations of arginine and ornithine lead to impaired urea cycle function and, subsequently, decreased protein tolerance. Patients often develop natural aversion to protein‐rich foods, which may predispose them to nutritional problems. The objective of this retrospective study was to investigate lipid values and efficacy of lipid‐lowering therapy in patients with LPI.Methods and resultsSerum total and high‐density‐lipoprotein (HDL)‐cholesterol and triglyceride concentrations were analyzed in 39 Finnish LPI patients (14 males) aged 3–64 years. Dietary intakes were analyzed from food records. Mean [standard deviation (SD)] serum and HDL‐cholesterol and triglyceride concentrations were 7.16 (2.13) mmol/l, 1.21 (0.58) mmol/l, and 4.0 (2.4) mmol/l, respectively. Patients with renal dysfunction had marginally higher total cholesterol and significantly higher triglyceride concentration than patients without renal impairment. Twenty‐two patients were started on 3‐hydroxy‐3‐methylglutaryl‐coenzyme A (HMG‐CoA) reductase inhibitors (atorvastatin or simvastatin). After 6 months, serum cholesterol and triglyceride concentrations had decreased by 32% (p < 0.001), whereas HDL‐cholesterol had increased by 13% (p = 0.016).ConclusionSerum cholesterol and triglyceride values are markedly elevated in LPI patients. Although the mechanism of combined hyperlipidemia remains unknown and is not explained by fat consumption, hyperlipidemia is clearly progressive with age, suggesting that starting statin therapy early is probably beneficial. Statins are well‐tolerated and efficacious in LPI.
Recombinant follicle‐stimulating hormone (follitropin alfa) versus purified urinary follicle‐stimulating hormone in a low‐dose step‐up regimen to induce ovulation in Japanese women with anti‐estrogen‐ineffective oligo‐ or anovulatory infertility: results of a single‐blind Phase III study
Authors: Taketani Yuji , Kelly Eduardo , Yoshimura Yasunori , Hoshiai Hiroshi , Irahara Minoru , Mizunuma Hideki , Saito Hidekazu , Andoh Kazumichi , Yanaihara Takumi 
Published: February 2010

AbstractPurposeWe aimed to compare the efficacy and safety of recombinant human follicle‐stimulating hormone (follitropin alfa) and purified urinary human follicle‐stimulating hormone (urofollitropin) for ovulation induction in Japanese women with anovulatory infertility;also to verify the noninferiority (in terms of ovulation rate) of follitropin alfa versus urofollitropin.MethodsIn a Phase III, multicenter, single‐blind, parallel‐group study, we enrolled 265 Japanese women aged 20–39 years. The patients were menstruating without apparent ovulation or were amenorrheic (with a positive progestin challenge test), and had failed to conceive with anti‐estrogen ovulation‐induction therapy. The patients underwent a low‐dose step‐up regimen using follitropin alfa or urofollitropin with a starting dose of 75 IU. The primary endpoint was the proportion of patients who ovulated (mid‐luteal serum progesterone ≥5 ng/mL and/or confirmed clinical pregnancy). Secondary endpoints included the proportion of patients with a dominant follicle (≥18 mm) and the duration of stimulation.ResultsOvulation occurred in 79.1% and 82.6% of the patients who received follitropin alfa and urofollitropin, respectively, in the full‐analysis set (n = 261), and in 79.2% and 82.5% of the per‐protocol set (n = 251). The predefined noninferiority criteria for the primary endpoint were achieved. No significant differences were observed in any secondary endpoint. Treatment‐emergent adverse events were reported by a similar proportion of patients in each group (follitropin alfa, 53.5%; urofollitropin, 50.0%).ConclusionsNo significant difference in the primary efficacy endpoint (rate of ovulation) was observed between follitropin alfa and purified urofollitropin in women with anovulatory infertility who were menstruating or had progestin‐positive amenorrhea. The use of treatment holidays in this study prevents comparison of the data with previous trials that utilized consecutive daily doses.
Enjeux psychosociaux du don de sperme: le point de vue des couples
Authors: Kalampalikis N. , Haas V. , Fieulaine N. , Doumergue M. , Deschamps G. , Chiron H. 
Published: February 2010

Résumé
Le débat national suscité en France à l’occasion de la révision des lois de bioéthique a porté en partie sur l’anonymat du don des gamètes. En effet, si nous nous focalisons uniquement sur le don de sperme, de nombreux avis émis prônent, à des degrés différents, une ouverture relative du statut actuel de l’anonymat du donneur de sperme. Cependant, qu’en est-il des couples impliqués dans une démarche de don ? Que souhaitent-ils ? Quels changements de pratiques sont survenus pour les couples receveurs de don au sein des pays ayant opté pour une levée de l’anonymat du donneur ? Notre article présente une partie des résultats d’une recherche psychosociale récente portant sur un échantillon significatif de la population des couples demandeurs en France. Les résultats portent aussi bien sur le vécu et l’intention du partage du secret de la conception par don de sperme, que sur le cadre spécifique de ce type de don et des principes qui le définissent du point de vue législatif en France. Enfin, nous interrogeons les principes organisateurs de leurs prises de position sur l’anonymat du don ainsi que la convergence des stratégies parentales dans des cadres législatifs divergents, à la lumière de la littérature scientifique internationale.
Outreach and screening following the 2005 London bombings: usage and outcomes
Authors: Brewin C. R. , Fuchkan N. , Huntley Z. , Robertson M. , Thompson M. , Scragg P. , d'Ardenne P. , Ehlers A. 
Published: February 2010

BackgroundLittle is known about how to remedy the unmet mental health needs associated with major terrorist attacks, or what outcomes are achievable with evidence-based treatment. This article reports the usage, diagnoses and outcomes associated with the 2-year Trauma Response Programme (TRP) for those affected by the 2005 London bombings.MethodFollowing a systematic and coordinated programme of outreach, the contact details of 910 people were obtained by the TRP. Of these, 596 completed a screening instrument that included the Trauma Screening Questionnaire (TSQ) and items assessing other negative responses. Those scoring ⩾6 on the TSQ, or endorsing other negative responses, received a detailed clinical assessment. Individuals judged to need treatment (n=217) received trauma-focused cognitive-behaviour therapy (TF-CBT) or eye movement desensitization and reprocessing (EMDR). Symptom levels were assessed pre- and post-treatment with validated self-report measures of post-traumatic stress disorder (PTSD) and depression, and 66 were followed up at 1 year.ResultsCase finding relied primarily on outreach rather than standard referral pathways such as primary care. The effect sizes achieved for treatment of DSM-IV PTSD exceeded those usually found in randomized controlled trials (RCTs) and gains were well maintained an average of 1 year later.ConclusionsOutreach with screening, linked to the provision of evidence-based treatment, seems to be a viable method of identifying and meeting mental health needs following a terrorist attack. Given the failure of normal care pathways, it is a potentially important approach that merits further evaluation.
Lung Abscess in Adults with Tetralogy of Fallot and Pulmonary Atresia
Authors: O’Donnell Clare P. , Landzberg Michael J. , Mullen Mary P. 
Published: February 2010

AbstractWe describe 5 adults with tetralogy of Fallot and pulmonary atresia who developed lung abscesses, including some infected with atypical microbial pathogens, with important morbidity. We hypothesize that patients with such anatomy are at risk for chronic pulmonary infection due to hypo-perfusion of the pulmonary parenchyma. This previously unreported clinical association should be considered in the differential diagnosis of patients with tetralogy of Fallot and pulmonary atresia who alter their respiratory state.
3 Aboriginal Women and Political Pursuit in Canadian Sentencing Circles
Authors: Goel Rashmi 
Published: February 2010

AbstractThis chapter addresses Canadian sentencing circles in domestic violence situations. It is argued that Aboriginal communities expect sentencing circles to serve certain political goals in addition to the traditional restorative justice goals—such as educating the broader society about historical and social contributors to criminality, promoting Aboriginal self-governance and incorporating Aboriginal dispute resolution into mainstream dispute resolution. The tension between these political goals and the traditional restorative justice goal limits the effectiveness of sentencing circles. Aboriginal victims of domestic abuse might not criticize the sentencing circles’ failure to address their harms as victims because this might undermine the legitimacy of Aboriginal dispute resolution methods. However, if this tension is recognized, better methods can be devised, to improve the effectiveness of sentencing circles, and minimize domestic abuse in Aboriginal families.
7 Restorative Justice and Youth Violence Toward Parents
Authors: Daly Kathleen , Nancarrow Heather 
Published: February 2010

AbstractChapter Abstract: This chapter presents three cases of sons’ violence against mothers that were handled by a diversionary youth conference, a restorative justice process. Drawing on interviews with conference coordinators and victims, the analysis considers the histories, contexts, and dynamics of the violence; what happened in the conference, including gendered power dynamics and re-victimization; and the women’s experiences during the conference and post-conference. The literature on youth parental violence and debates on the appropriateness of restorative justice for domestic or partner violence cases is reviewed and assessed. The dynamics of male youth offender cases are similar to those of their adult counterparts; and thus, the youth cases provide insight on the strengths and limits of restorative justice for partner violence.