bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Oxytocin and Prostaglandin F2α on Pregnant Human Myometrium Recorded by the Single Sucrose‐Gap Method –Comparison of an in vitro Experiment and an in vivo Trial–
Authors: Kawarabayashi Tatsuhiko , Sugimori Hajime 
Published: August 2010

AbstractEffects of oxytocin and prostaglandin F2α on the electrical and mechanical activities of the pregnant human isthmic myometrium were investigated by a single sucrose‐gap method.Human isthmic myometrium obtained at the late stage of gestation showed plateau‐ and spike‐type action potentials. Both oxytocin and PGF2α potentiated the spontaneous contractions by affecting the plateau part of action potentials; spike‐type configurations became plateaus. However, high dosages of both drugs were required to obtain consistent excitatory effects in vitro. In obstetric practice, on the other hand, uterine contractions can be induced by low‐doses of oxytocin or PGF2α.These results suggest that both oxytocin and PGF2α can increase spontaneous contractions by enhancing plateau potentials in vitro. However, the pharmacological application of oxytocin or PGF2α might only play a triggering role in uterine contractions at induction or augmentation of labor, and complex interactions might be involved in the initiation and potentiation of contractions in vivo.
Menstrual Fistula following Caesarean Section
Authors: Agrawal V. , Sapre S. , Shrivastava S. K. , Patil S. 
Published: August 2010

SummaryMenstrual fistula is a ver‐ rare complication after caesarean section. In Kamla Raja Hospital attached to G. R. Medical College, Gwalior 5620 caesarean sections were done from 1972 to 1981 with no such complications. Hence, this case is reported.
Endometrial Ossification
Authors: Purwar M. , Deshpande A. , Jain L. S. 
Published: August 2010

AbstractIrregular growth of bone was seen in the endometrial tissue after h‐sterectom‐ from a fortear old woman, four ‐ears after a therapeutic abortion. Implantation of fetal remnants into the uterine wall at the time of instrumentation has been considered as a source of heterotopic tissue.
Late Recurrence of Granulosa Cell Tumour
Authors: Pal S.K. , Chowdhury N.N. Roy 
Published: August 2010

AbstractStromal tumours of the ovary exhibit varying degree of malignant potential. Recurrence of the tumour long after the removal of primary one is not uncommon. In the present communication a case is described where total hysterectomy with bilateral salpingoophorectomy was done for unilateral well capsulated granulosa cell tumour of right ovary, at the age 40 years. Unfortunately there was metastasis at vulva 25 years after the primary operation.
Expectant Treatment Versus Conservative Treatment in the Management of Mild Endometriosis
Authors: Wong P.C. , Heng S.H. , MBBS Jothi Kumar , Tan E.L. , Yeoh S.C. , Ratnam S.S. 
Published: August 2010

AbstractThis is a retrospective analysis of 157 subfertile patients with mild endometriosis confirmed at laparoscopy. 80.3% of them were Chinese and the Malays and Indians accounted for 8.9% and 8.3% of the cases respectively. Most of the patients were in the 25–29 patients year old age group and their mean duration of subfertility was 4.3 years.Ninety‐five patients were treated by either conservative surgery or medical therapy with norethisterone or danazol. The pregnancy rate' was 29.5%. 82% of these pregnancies occurred within 18 months after completion of treatment. 62 patients were not treated. The pregnancy rate was 38.7% and all of them conceived within 18 months from confirmation of diagnosis. Although the untreated group had more pregnancies, the difference was not statistically significant.The authors propose that subfertile patients with mild endometriosis should not be treated but followed up for 18 months. Those who fail to conceive after this period may then be treated.
Pregnancy Outcome in Patients with Regular Menses
Authors: Brodribb James K.R. , Correy Joseph F. , Schokman Frederick CM. 
Published: August 2010

Summary49% of patients with regular menstrual cycles attending the infertility clinic at the Royal Hobart Hospital were found to be anovulatory. When other factors were sought, 18% of spouses were found to have an abnormal semen profile, an incidence shared equally between ovulatory and anovulatory patients. A significant number were found to have pelvic pathology in spite of previous investigations.The overall outcome in terms of pregnancy was 56% in the ovulatory group and 47% in the anovulatory group. Of the 19% of patients where no cause could be found, the pregnancy rate was 57%. Continued attendance at the clinic resulted in a better outcome in both ovulatory and anovulatory patients. Whereas the pregnancy rate in anovulatory defaulters was considerably lower it was nevertheless 31% suggesting that the ovulatory defects in those patients with regular menses was of a temporary nature.
Differential Diagnosis between Uterine Myoma and Endometriosis using CA 125 as a New Tumor Marker of Ovarian Carcinoma
Authors: Takahashi Kentaro , Kijima Satoshi , Yoshino Kazuo , Shibukawa Toshihiko , Murao Fuminori , Kitao Manabu 
Published: August 2010

AbstractFor a preoperative differentiation between leiomyomata uteri and adenomyosis, we measured serum levels of the antigen CA 125, which is specific to ovarian non‐mucinous epithelial carcinoma, in patients with benign gynecologic diseases (39 leiomyomata uteri, 10 adenomyosis, 4 adenomyosis with leiomyomata uteri, 3 adenomyosis with external endometriosis and 4 external endometriosis). Using radio‐immunoassay (RIA) kit, we found the normal range of CA 125 levels to be below 34 U/ml. The mean CA 125 level (±S.D.) was 20.3 ± 10.3 U/ml in patients with leiomyomata uteri and 151.2 ± 157.3 U/ml in those with adenomyosis. The mean CA 125 level in patients with leiomyomata uteri was not statistically higher than that in disease‐free women. The mean CA 125 level in patients with adenomyosis was statistically higher than that in disease‐free women. Of 17 patients with surgically demonstrable adenomyosis, the CA 125 values were over 34 U/ml in 16 (94.1%). Three (75%) of 4 patients with surgically demonstrable external endometriosis had a serum CA 125 level in excess of 34 U/ml. Of 39 patients with surgically demonstrable leiomyomata uteri, CA 125 levels were below 34 U/ml in 37 (94%). CA 125 levels in patients with adenomyosis gradually decreased postoperatively and all were below 34 U/ml within four weeks. Using this approach, leiomyomata uteri and adenomyosis can be differentiated preoperatively and the response to treatment in patients with endometriosis can be monitored.
Synchronization of Uterine Contractions Recorded by Guard‐Ring Tocodynamometer
Authors: Nakahara Hiromasa , Kawarabayashi Tatsuhiko , Ikeda Masahiko , Uchiumi Yoshio , Sugimori Hajime , Nakano Hitoo 
Published: August 2010

AbstractThe synchronization of local uterine contraction waves recorded by external tocodynamometers was studied and the following results were obtained:

When two guard‐ring tocodynamometers were attached to the fundus and the caudal part of the uterus 20 cm apart, the synchronizing ratio of ascending points of the lower fifth of the contraction waves was significantly higher in the active phase than in the latent phase of labor.
Nearly regular upward or downward conduction of contractions between the fundus and the caudal part of the uterus was observed in each case.
The synchronizing ratio of peaks of small contraction waves was almost the same as the ratio in the active phase of labor.

The results suggested the necessity of re‐evaluation of the contraction curve recorded by the external tocodynamometer in view of the synchronization of contractions, instead of the amplitude, to control uterine contractions in preterm or term labor.
Endometrial Jet Washings in High Risk Women
Authors: Souka Abdel Razak A. , Chanem Aly , Hiba Nasr , Kamel Moustafa A.M. , Einen Moustafa A. 
Published: August 2010

AbstractThe endometrial washings from 50 women in the high risk group were obtained by the Gravlee jet washer. Specimens were examined cytologically and by the cell block technique. Confirmatory procedures as D & C or hysterectomy were done in 39 cases. The procedure was successful in all cases but insufficient specimens for diagnosis were encountered in 18% of the cases. Gravlee jet washing specimens studied by the cell block technique proved to be a valuable procedure for the detection of endometrial lesions. It is only when the washings are unsatisfactory that further confirmatory evidence is indicated.
Small‐for‐Gestational‐Age (SGA) Neonates: A Study of Blood Coagulation and Fibrinolysis
Authors: Fuse Yoji 
Published: August 2010

AbstractThe author examined 68 subjects with normal pregnancy and delivery for blood coagulation and fibrinolysis to determine the cause of birth of small‐for‐gestational‐age (SGA) neonates.In the umbilical blood, the SGA group showed significant decreases in platelet count, plasminogen and alpha2‐plasmin inhibitor (p < 0.05), as compared with the appropriate‐for‐gestational‐age (AGA) and large‐for‐gestational‐age (LGA) group. In the maternal blood in the third trimester, the SGA‐neonate‐delivery group showed hypercoagulation, inhibition of fibrinolysis and platelet hyperfunction, as compared with the AGA‐ and LGA‐ neonate‐delivery groups. Particularly, prothrombin time significantly decreased (p < 0.002). There was a correlation between prothrombin time of the maternal blood and neonatal birth weight (r = 0.38446, p < 0.01).The above results suggested that these changes in blood coagulation and fibrinolysis had an influence on the decrease in the utero‐placental blood flow, related to the birth of SGA neonates. It was also inferred that prothrombin time of the maternal blood in the third trimester can become a parameter for predicting the birth of a SGA neonate.
Assessment of Fetal Heart Rate Variability with Abdominal Fetal Electrocardiogram: Changes During Fetal Breathing Movement
Authors: Ohno Yohsuke , Tsuji Masamichi , Fujibayashi Hideko , Tomioka Megumi , Yamamoto Takao , Okada Hiroji 
Published: August 2010

AbstractFetal heart rate and beat‐to‐beat variability during fetal breathing movements were investigated by abdominal fetal electrocardiography. The mean (M‐RR) and the standard deviation (SD‐RR) of R‐R intervals and the percentage of absolute beat‐to‐beat differences below 2 msec (2 msec %) were measured by computerized quantification. Fetal breathing movements were associated with a significant increase in SD‐RR (from 8.73 ± 5.59 during apnea to 16.7 ± 5.67 during breathing) and a significant decrease in 2 msec % (from 44.1 ± 12.4 during apnea to 27.9 ± 8.65 during breathing). According to discriminant analysis, the 2 msec % was the best coefficient for classifying fetal breathing episodes. Thus the determination of 2 msec % is useful in assessing fetal heart rate variability by abdominal fetal electrocardiography.
A Topographic Investigation of the Site of Origin and Subsequent Propagation of Uterine Contractions in Spontaneous Labor and Their Clinical Significance
Authors: Takagi K. , Matsuura M. , Sakata H. , Takagi S. 
Published: August 2010

AbstractThis investigation involves the non‐invasive collection of data concerning the events associated with spontaneous labor contractions, by the utilization of computer processed abdominal surface potentials (ASP), graphically displayed two dimensionally as topograms.Subjects were 19 healthy women volunteers experiencing normal pregnancies of 37—41 weeks duration who were admitted due to the onset of spontaneous labor. Sixteen of these subjects progressed to normal vaginal deliveries.We were able to classify the electrical events displayed on the topograms into mono‐and multifocal origins of high power areas (HPA), with the monofocal origins leading to synchronous, and the multifocal leading to asynchronous patterns of bioelectric propagation.We feel that the use of topograms may prove to be of clinical value in assessing the progress of labor.
In vitro Study on Thyroid Hormone Metabolism of Human Placenta in Early Pregnancy
Authors: Adachi Tomoko , Maeda Michiko , Nomoto Teruko , Tsukahara Fujiko , Sakamoto Shoichi , Takeda Yoshihiko 
Published: August 2010

AbstractThyroid hormone metabolism in human chorionic villi and decidua at 6—11 weeks of gestation, obtained at induced abortion, were studied.The homogenates of chorionic villi and decidua were incubated with 20 mM DTT with outer ring labeled 125I‐T4, 125I‐T3 or 125I‐rT3. 125I‐compounds generated during incubation were separated by paper chromatography or thin layer chromato‐graphy and the radioactivity of each compound was measured.Chorionic villi homogenates deiodinated the inner ring of active thyroid hormone, T4 or T3 yield the inactive iodothyronines, rT3 or 3,3′‐diiodothyronine and 3′‐monoiodothyronine, respectively. These results are similar to those found using term placental homogenate. Reverse T3 was also degraded in chorionic villi, while almost no deiodination of rT3 in human term placenta has been reported.In decidua, deiodination of T4 and rT3 was not detected but inner ring deiodination of T3 was found.These findings suggest that placental transfer of T4 and T3 to the fetus could be regulated, even prior to completion of the placental organ, via deiodination of these compounds.
Biological Characteristics of Cultured Endometrial Adenocarcinoma Cells and Changes in Their Characteristics Following Serial Passage
Authors: Ishiwata Isamu , Ishiwata Chieko , Nozawa Shiro , Ishikawa Hiroshi 
Published: August 2010

AbstractWe cultured variously differentiated human endometrial adenocarcinomas to study changes in their biological characteristics due to serial passage.

In primary cultures of endometrial adenocarcinoma, morphological features of the cultured cells were as well differentiated as the tissue differentiation in the original culture materials; with increase in the number of subcultures, however, the cultured cells turned gradually into uniformly poorly differentiated adenocarcinoma cells.
The growth rate was slightly accelerated with successive subcultures.
The modal chromosome number was stable at the diploid range.
The sensitivity to estradiol‐17β and progesterone decreased with successive subcultures.
The poorly differentiated cells after subculture again showed differentiation upon treatment of progesterone.
Microsurgical Reversal of Tubal Sterilization
Authors: Chang Yoon Seok , Kim Jung Gu 
Published: August 2010

AbstractThree hundred and sixty patients underwent a microsurgical reversal of tubal sterilization. One hundred and eighty‐eight (57.2%) of these patients had been sterilized by laparoscopic cauterization. In the majority (66.4%) the reason for requesting reversal was a loss of child. The mean interval between sterilization and reversal was 39.3 months. The postoperative tubal length was 6 cm or more in 74.2%. One hundred and fifty‐one (60.4%) of 250 patients followed up for 14 to 59 months have achieved 181 pregnancies. The postoperative tubal patency rate was 88.3%. The mean interval between the surgery and the occurrence of pregnancy was 8.9 months. The success rate was analyzed according to type of sterilization procedure, duration of sterilization, site of anastomosis and postoperative tubal length.
A Prospective Study in 38 Patients with Abruptio Placentae of 70 Cases Complicated by DIC
Authors: Terao Toshihiko , Maki Masahiro , Ikenoue Tsuyomu 
Published: August 2010

AbstractDisseminated intravascular coagulation (DIC) diagnostic criteria for obstetrics as a clinical scoring system were established.These criteria, in which more weight was given to the underlying disease and to clinical findings than to laboratory parameters (coagulation tests), agree closely with the DIC diagnostic criteria of the Japanese Ministry of Health and Welfare.Efficacy evaluation criteria for obstetric DIC were also defined to enable follow‐up of the clinical efficacy of DIC therapy. The clinical usefulness of these criteria was confirmed by comparison of infusion efficacy between AT III concentrate (Behring‐werke AG) and injectable FOY? (Ono Pharmaceutical Co., Ltd.) for the 38 DIC cases with abruptio placentae collected here. The total score, FDP score, and platelet score were improved markedly in the AT III group compared with the FOY group.
Serum Levels of Norethisterone, Estradiol and Progesterone after Administration of Norethisterone Oenanthate at Different Sites: A Cross‐Over Study
Authors: Virutamasen Pramuan , Dhanapas Siriporn , Leepipatpaiboon Samai 
Published: August 2010

AbstractTwenty healthy female volunteers were enrolled of this study. The subjects were randomly divided into 10 for each group. One group received a single injection of norethisterone oenanthate (NET‐EN) via gluteal muscle, the rest received NET‐EN via deltoid muscle. The study had a cross‐over design and after the first injection period of 8 weeks, there was a steroid‐free period of 8 weeks. Blood samples were collected weekly. The serum concentration of norethisterone, estradiol and progesterone were measured by radioimmunoassay. It was found that the elimination rate constant, Tl/2 and area under the curve for the gluteal and deltoid group were not significantly different. The peak levels of NET in the serum was somewhat high in the deltoid injection group. The ovarian suppression with NET‐EN in some women may last only 60 days or less.
Chorioangioma of the Placenta: A Case Report
Authors: Raman S. , Rachagan S. P. , Ng K. B. , Peh S. C. 
Published: August 2010

AbstractFollowing a quick vaginal delivery of a preterm infant, the placenta was delivered with some difficulty. A globular mass approximately 10 cm in diameter was seen attached to the maternal surface of the placenta by large veins. Histology revealed it to be a large chorioangioma. This tumour was asymptomatic and there were no maternal or fetal complications.
C‐Band Polymorphism of Chromosome No. 1 in Patients with Polycystic Ovary Disease
Authors: Nur Jinnatun , Grewal M. S. , Guron C.J.S. , Buckshee K. 
Published: August 2010

AbstractThe C‐band polymorphism of chromosome No. 1 was evaluated in IS women (polycystic ovary disease‐10, normal‐5) using C‐band technique. In 8 patients one of the C‐segments was significantly smaller (in the ratio of C‐segment to the arm) than that of their homologues and in 2 cases both the C‐segments were of normal and equal size. The mean length of the C‐segments of one of the No. 1 chromosomes was 1.310; tm and that of its homologue was 1.125 μm, whereas in the control group the mean length of both the C‐segments was 1.220 μm. A positive family history of polycystic ovary disease could be elicited in 75% cases in one or more of the first and second degree relatives thus indicating that the disease runs in the family. It was further observed that 80% (8/10) subjects with polycystic ovary disease revealed significant heterochromatic aberration as apposed to only variations in the case of normal subjects.
Fetal Heart Rate Response to Scalp Stimulation as a Test of Fetal Well‐Being in Labour
Authors: Arulkumarany S. , Ingemarsson I. , Ratnam S. S. 
Published: August 2010

AbstractFetal scalp stimulation with an Allis' tissue forceps applied on the baby's scalp for 15 seconds was performed in 50 patients with suspicious or ominous fetal heart rate (FHR) changes on the cardiotocographic trace in the first stage of labour. The FHR response was correlated with fetal blood pH obtained from the scalp (FBS) shortly after the test. An acceleration of the FHR of at least 15 beats above the baseline for at least 15 seconds was regarded as a positive test.Forty (80.0%) of the 50 fetuses responded with a positive test. Six (15.0%) had a preacidotic value (7.20–7.25) and 3 of them developed acidosis later and were delivered abdominally. Of the 34 with normal pH (>7.25) only one had to be delivered by a caesarean section (CS) for fetal distress later in labour. Ten (20.0%) of the 50 fetuses had a negative test; two were acidotic (<7.20) and 5 preacidotic. All had a scalp pH below 7.29. Six of them had a CS for fetal distress later in labour.These preliminary results suggest that in cases with suspicious or ominous FHR traces if the fetus responds with an acceleration to a painful stimulus the risk of fetal acidosis is small. However, the baby might be preacidotic and careful monitoring and a repeat FBS may be necessary if ominous FHR changes persist or deteriorate. If the test is negative the risk of fetal acidosis or preacidosis is considerable (70.0%). FBS is the diagnostic method of choice in cases suggestive of fetal acidosis but a scalp stimulation test might be useful in institutions without facilities for FBS and in situations where a sampling of fetal blood is difficult.
Pre‐Operative Sonographic Assessment of Lower Genital Tract Anomalies
Authors: Mukhopadhyay J. , Ghosh A. , Ho P. C. 
Published: August 2010

AbstractA 14‐year‐old Chinese girl with cryptomenorrhoea was found to have normal stature, secondary sex characters and external genitalia but a blind suburethral pouch 0.5 cm in diameter and a globular pelvic mass 6times4 cm in diameter. Ultrasonography indicated haematometra, left haematosalpinx, atretic cervix and vagina.The diagnosis was confirmed at laparotomy. Total hysterectomy left salpingectomy and left ovarian cystectomy was performed.
Effect of a Calcium Antagonist (ICI 109,081) upon Follicular Steroidogenesis and Oocyte Maturation in the Golden Hamster
Authors: Matson Phillip L. , Collins William P. 
Published: August 2010

AbstractThe effect of a calcium antagonist (a derivative of dihydropyridazinone: ICI 109,081), upon oocyte maturation, and steroid production by pre‐ovulatory hamster follicles was determined. Sexually immature golden hamsters were injected with 40 iu PMSG, and pre‐ovulatory follicles (591–740 μm) were isolated after 72–78h. The culture of intact follicles in medium containing 1 μg/ml ICI 109,081 showed an increased output of progesterone (p<0.05). However, in the presence of LH, ICI 109,081 was seen to cause significant decreases in the output of progesterone, 17α‐hydroxyprogesterone and androstenedione (all p<0.05) with a significant increase in the production of oes‐tradiol (p<0.05). The culture of oocytes isolated 72h after PMSG showed significant reductions in the number of oocytes resuming meiosis when compared with controls (94%) for ICI 109,081 concentrations of 0.1 μg/ml (58%, p<0.05) and 1 μg/ml (32%, p<0.05). Smilarly, the pre‐treatment of animals with 3 mg ICI 190,081 lh before injection of 25 iu hCG, caused the ovulation of 96/98 ova with an intact germinal vesicle. The results suggest a role of calcium in the regulation of oocyte maturation, and as a mediator in the action of LH upon steroidogenesis by pre‐ovulatory follicles.
Sirenomelia: A Case Report
Authors: Pratap Sheela , Nalini V. , Rao Ravikala V. , Rao P.L.N.G. 
Published: August 2010

AbstractA case of sirenomelia along with its complete autopsy findings is reported. It is suggested that whenever a congenital anomaly is diagnosed prenatally, either by imaging technics or any other investigative procedures‐the option of termination should be made available to the couple to avoid any psychological trauma, which they may experience when such pregnancy is carried to term.
A Case Report of Bilateral Absence of Fallopian Tubes and Ovaries
Authors: Chan Clement L. K. , Leeton John F. 
Published: August 2010

AbstractA case of bilateral absence of ovaries and fallopian tubes is reported. This is the first case reported in the last 50 years. The patient was concerned about her fertility potential. The etiologies of this condition are reviewed and the past, present and future management of such a condition is discussed.