bluuebunny/crossref_metadata_2025_split huggingface dataset:
The challenge of adopting a collaborative information system for independent healthcare workers in France: a comprehensive study
Authors: Gaucher Laurent , Puill Céline , Baumann Sophie , Hommey Sophie , Touzet Sandrine , Rudigoz René-Charles , Cortet Marion , Huissoud Cyril , Gaucherand Pascal , Dupont Corinne , Mougeot Frédéric 
Published: May 2024

AbstractThis study aimed to explore the perception of an underutilised collaborative information system through qualitative research, utilizing semi-structured, in-depth interviews with independent midwives and physician. PROSPERO, is a collaborative information system designed to bridge the communication gap between community-based healthcare workers and hospital-based care teams for parturients in Lyon, France. Through 27 semi-structured in-depth interviews with midwives, obstetricians, and general practitioners, we identified key themes related to the system’s adoption: implementation challenges, utilisation barriers, interprofessional dynamics, and hidden variables affecting system use. Participants recognised the potential of PROSPERO to improve information sharing and care coordination but expressed concerns about the system’s integration into existing workflows, time constraints, and the need for adequate training and technical support. Interprofessional dynamics revealed differing perspectives between hospital and independent practitioners, emphasising the importance of trust-building and professional recognition. Hidden variables, such as hierarchical influences and confidentiality concerns, further complicated the system’s adoption. Despite the consensus on the benefits of a collaborative information system, its implementation was hindered by mistrust between healthcare workers (i.e. between independent practitioners and hospital staff). Our findings suggest that fostering trust and addressing the identified barriers are crucial steps towards successful system implementation. The study contributes to understanding the complex interplay of factors influencing the adoption of collaborative healthcare technologies and highlights the need for strategies that support effective interprofessional collaboration and communication.ClinicalTrials ID NCT02593292.
Juvenile peripheral LPS exposure overrides female resilience to prenatal VPA effects on adult sociability in mice
Authors: Seiffe Araceli , Kazlauskas Nadia , Campolongo Marcos , Depino Amaicha Mara 
Published: May 2024

AbstractAutism spectrum disorder (ASD) exhibits a gender bias, with boys more frequently affected than girls. Similarly, in mouse models induced by prenatal exposure to valproic acid (VPA), males typically display reduced sociability, while females are less affected. Although both males and females exhibit VPA effects on neuroinflammatory parameters, these effects are sex-specific. Notably, females exposed to VPA show increased microglia and astrocyte density during the juvenile period. We hypothesized that these distinct neuroinflammatory patterns contribute to the resilience of females to VPA. To investigate this hypothesis, we treated juvenile animals with intraperitoneal bacterial lipopolysaccharides (LPS), a treatment known to elicit brain neuroinflammation. We thus evaluated the impact of juvenile LPS-induced inflammation on adult sociability and neuroinflammation in female mice prenatally exposed to VPA. Our results demonstrate that VPA-LPS females exhibit social deficits in adulthood, overriding the resilience observed in VPA-saline littermates. Repetitive behavior and anxiety levels were not affected by either treatment. We also evaluated whether the effect on sociability was accompanied by heightened neuroinflammation in the cerebellum and hippocampus. Surprisingly, we observed reduced astrocyte and microglia density in the cerebellum of VPA-LPS animals. These findings shed light on the complex interactions between prenatal insults, juvenile inflammatory stimuli, and sex-specific vulnerability in ASD-related social deficits, providing insights into potential therapeutic interventions for ASD.
Experimental and numerical investigations on stress concentration factors of concrete filled steel tube X-joints
Authors: Diao Yan , He Shiyi , Wang Yukai , Tu Liu 
Published: May 2024

AbstractAn SHS-CFSHS X-joint is fabricated by welding two square hollow section (SHS) braces to a concrete-filled square hollow section (CFSHS) chord. In this paper, the stress concentration factors (SCFs) of SHS-CFSHS X-joints are investigated through experimental tests and finite element analysis (FEA), with the hot spot stress method serving as the analytical approach. Eight specimens are designed and manufactured, with FE models built in software ANSYS. These FE models are validated against the test results. The specimens are tested under brace axial tension to determine the SCFs of the X-joints. It shows that the concrete filled in the chord effectively reduces the SCFs of the X-joints. To further explore various load conditions and the influence of the parameters, FEA is carried out and a total of 64 FE models are built. Based on the FEA results, multiple regression analysis is used to obtain the SCF formulae of SHS-CFSHS X-joints under axial tension load and in-plane bending load in the brace, respectively. Comparison and analysis of the SCF results obtained from experimental tests, the proposed formulae, and FE simulations reveal that the formulae presented in this study are both conservative and suitable for predicting SCFs.
Ruptura do peitoral maior em adolescente de 15 anos: Relato de caso
Authors: Piluski Paulo César Faiad , Bonadiman João Artur , Moreira Eduardo Necher , Rodriguez Carlos Humberto Castillo , Lech Osvandré 
Published: May 2024

ResumoA ruptura do músculo peitoral maior é extremamente rara em adolescentes. Na literatura atual, existem apenas 5 relatos em pacientes com menos de 20 anos, sendo 2 em pacientes com menos de 16 anos de idade. Neste artigo, relatamos o caso de uma jogadora de vôlei de 15 anos que sofreu uma ruptura traumática do peitoral maior em uma partida durante o movimento de saque. Após a exclusão de causas endocrinológicas – que poderiam ter provocado o enfraquecimento tendíneo –, o tratamento cirúrgico foi escolhido devido à retração muscular, ao déficit de força, à alta demanda e às preocupações estéticas. O diagnóstico precoce é crucial para que se obtenham bons resultados, e a intervenção cirúrgica propiciou a reabilitação precoce e uma maior probabilidade de retorno ao esporte de competição em alto nível.
Análise do comportamento biomecânico de um modelo animal de configuração de enxerto de trança tripla de isquiotibiais para reconstrução combinada de LCA e LAL para túnel único femoral
Authors: Cavalcante Maria Luzete Costa , Clazzer Renata , Helito Camilo Partezani , Codes Rodrigo Nogueira de , Lima Lana Lacerda de , Ariel de Lima Diego 
Published: May 2024

Resumo
Objetivo Descrever e testar biomecanicamente uma configuração, num modelo animal que simula o enxerto triplo de isquiotibiais para a reconstrução combinada do ligamento cruzado anterior (LCA) e do ligamento anterolateral (LAL), com apenas um túnel femoral e somente uma “perna” para a reconstrução do LAL.
Métodos Tendões flexores profundos de suínos foram utilizados como enxerto e fixados com parafusos de interferência de titânio num bloco de poliuretano. As amostras foram divididas em 3 grupos: grupo 1 (controle) – com enxerto quádruplo; grupo 2 – com enxerto triplo simples; e grupo 3–com enxerto triplo trançado. Os testes foram realizados com uma máquina universal de ensaios eletromecânica EMIC DL 10000 (Instron Brasil Equipamentos Científicos Ltda., São José dos Pinhais, PR, Brasil).
Resultados As amostras dos grupos 1, 2 e 3 alcançaram forças de pico médias de 816,28 ± 78,78 N, 506,95 ± 151,30 N e 723,16 ± 316,15 N, respetivamente. No Grupo 3, o trançado aumentou o diâmetro do enxerto entre 9% e 14%, e causou um encurtamento de 4% a 8% em comparação ao grupo 1, com um aumento médio da força de pico de ∼ 200 N (p < 0,05). Não houve diferença estatisticamente significativa entre os grupos 1 e 3 com relação às forças de pico, o que indica que os enxertos quádruplos e triplos trançados apresentaram resultados de força semelhantes.
Conclusão A configuração do enxerto de isquiotibiais com trança tripla para a reconstrução combinada do LCA e do LAL com um só túnel femoral e uma só “perna” para a reconstrução do LAL pode se tornar uma solução biomecanicamente viável, com potencial aplicação clínica.
Imobilização do punho após a descompressão cirúrgica do nervo mediano na síndrome do túnel do carpo: Uma revisão sistemática
Authors: Barbosa Thiago Moreth da Silva , Ferraz Ítalo Carvalho 
Published: May 2024

Resumo
Objetivo A neuropatia compressiva mais comum dos membros superiores é a síndrome do túnel do carpo (STC). Historicamente, houve uma tendência à aplicação de imobilização no pós-operatório, prática que tem diminuído nos últimos anos. O objetivo desta revisão é avaliar se existem evidências científicas que justifiquem o uso da imobilização nos cuidados pós-operatórios de descompressão da STC.
Métodos Foram utilizadas as seguintes bases de dados: Biblioteca Virtual em Saúde (BVS), PubMed National Library of Medicine (NLM), Cochrane Library, Scientific Electronic Library Online (SciELO), e EMBASE. Foram utilizados os seguintes critérios de inclusão: 1) discussão do pós-operatório de cirurgias de descompressão do nervo mediano na STC; 2) comparação dos resultados, após descompressão cirúrgica, na STC entre imobilização do punho ou apenas curativo local; 3) todos os idiomas, independentemente do ano de publicação; e 4) todos os tipos de publicações. Foram utilizados os seguintes critérios de exclusão: 1) estudos que não avaliaram o pós-operatório de descompressão da STC; 2) falta de avaliação do resultado relacionado à conduta de aplicação de curativo local e/ou alguma forma de imobilização do punho após o procedimento cirúrgico de descompressão; e 3) publicações repetidas
Resultados A busca bibliográfica resultou em 336 publicações relevantes. Ao final, foram escolhidas 18 publicações. Foram encontradas revisões sistemáticas, ensaios clínicos randomizados e estudos transversais.
Conclusões Devido à escassez de evidências que apoiem o uso da imobilização, associada aos custos mais elevados relacionados com a prática, nas últimas décadas, essa tem se tornado cada vez menos frequente.
Relevância clínica Na literatura há descrições de duas abordagens nos cuidados pós-operatórios de descompressão da STC: imobilização ou apenas curativo local. Vale a pena avaliar qual é a melhor entre as duas de acordo com as evidências científicas disponíveis.
Neurogenesis and pesticides: news of no new neurons
Authors: Scorza Fulvio A. , Almeida Antonio-Carlos G. de , Fiorini Ana C. , Chaddad-Neto Feres , Finsterer Josef 
Published: May 2024

AbstractNew hippocampal neurons are continuously generated in the adult human brain. Several studies have demonstrated that the proliferation of hippocampal cells is strongly influenced by a variety of stimuli, including pesticides exposure. These effects are particularly important because neurogenesis dysregulation could be associated with the decline of neuronal and cognitive functions and the possible development of neuropsychiatric disorders.
Morphology and electrical conductivity of carbon-coated Nickel reinforced high-performance polymer nanocomposites
Authors: Gadve R D , Goyal R K 
Published: May 2024

Abstract
Novel nanocomposites of poly (ether-ketone) (PEK) reinforced with carbon-coated Nickel nanoparticles (CCNi) were synthesized through a sequential process involving cost-effective ball milling and hot compaction. Scanning electron microscopy revealed an excellent dispersion and a three-dimensional network of CCNi nanoparticles in the matrix, causing a significant improvement in the electrical conductivity and electromagnetic interference shielding effectiveness (SE). Carbon coating of about 5 nm thick over Ni nanoparticle probably helps in uniform dispersion, avoids its oxidation and reduces its agglomeration in the matrix. An exceptionally low percolation threshold of 2.1 vol.% CCNi was found, and eight-orders of magnitude enhancement in the dc-electrical conductivity was achieved. The highest dc- and ac-electrical conductivities achieved were more than 0.01 S cm−1 at 5.89 vol.% CCNi nanoparticles content which were the highest values amongst reported Ni-filled polymer composites and comparable with those of carbon nanotubes filled PEK nanocomposites. Electromagnetic interference SE of the CCNi/PEK nanocomposites was measured in the X-band, and a total SE (SET) of 17.52 dB was obtained for 5.89 vol.% CCNi reinforced PEK nanocomposite.
Studies of carrier transport mechanism in NiO/Ag/NiO transparent conducting electrode/ZnO metal-semiconductor-metal photodetectors
Authors: Hwang J D , Liou Y R , Chiou Y J 
Published: May 2024

Abstract
Oxide/metal/oxide multilayers as a transparent conducting electrode (TCE) have been developed to replace metals due to their high transparency and low sheet resistance. Nickel oxide (NiO) film with a high work function was used as an oxide to form NiO/Ag/NiO (NAN) TCE, therefore a high barrier height between NAN/zinc oxide (ZnO) interface. In the study, NAN TCE was deposited on ZnO surface to fabricate metal-semiconductor-metal (MSM) photodetectors (PDs) and study its carrier transport mechanism. The NAN TCE has a low sheet resistance of 6.5 Ω/sq. and transmittance more than 40% in a 300−1000 nm wavelength range. Such issues result in the figure-of-merit is higher (2.3 × 10−4 Ω−1) than that (2.5 × 10−7 Ω−1) of pure single NiO thin film. As compared to the conventional Au/ZnO MSM-PDs, the NAN/ZnO MSM-PDs demonstrates a lower leakage current as a result of Ni atoms diffusing into ZnO and passivating the defects. Due to the high work function of NiO, the NAN/ZnO interface exhibits a barrier height as high as 0.91 eV. The Au/ZnO MSM-PDs reveals only one carrier conduction of ohmic due to the electrons tunnel form Au into ZnO through the surface defects. In contrast, two distinct carrier transport mechanisms were observed in the NAN/ZnO MSM-PDs. At low-voltage for

V
⩽
0.64

V

, ohmic conduction dominates and the electrons inject from NAN to ZnO, trapped by the defect states of ZnO. At high-voltage for

V
⩾
0.64

V

, the trapped electrons acquire enough energy and emit from trap to conduction band, entering Poole–Frankel emission transport.
Temperature dependence of microwave losses in lumped-element resonators made from superconducting nanowires with high kinetic inductance
Authors: Scarano E , Arvidsson E K , Roos A K , Holmgren E , Haviland D B 
Published: May 2024

Abstract
We study the response of several microwave resonators made from superconducting NbTiN thin-film meandering nanowires with large kinetic inductance, having different circuit topology and coupling to the transmission line. Reflection measurements reveal the parameters of the circuit and analysis of their temperature dependence in the range 1.7–6 K extract the superconducting energy gap and critical temperature. The lumped-element LC resonator, valid in our frequency range of interest, allows us to predict the quasiparticle (QP) contribution to internal loss, independent of circuit topology and characteristic impedance. Our analysis shows that the internal quality factor is limited not by thermal-equilibrium QP, but an additional temperature-dependent source of internal microwave loss.
DTT toroidal field conductor samples test in Sultan: DC and AC characterization
Authors: Fiamozzi Zignani C , De Marzi G , Scarantino G , Di Zenobio A , Muzzi L , Turtù S , Bonifetto R , Zappatore A , Polli G M , Ramogida G , Bajas H , Ortino M , Sedlak K 
Published: May 2024

Abstract
The superconducting magnet system of the Divertor Tokamak Test (DTT) facility, composed of 18 toroidal field (TF) coils, 6 poloidal field coils and a central solenoid, has been designed and many procurements have been launched. Some manufacturing aspects and some conductor features require characterization under relevant close-to-operative conditions. To confirm the design choices in all details, cryogenic tests in qualified facilities have been foreseen. In this work, the results of the TF samples characterization at the SULTAN facility at the Swiss Plasma Centre (SPC, EPFL) are presented. The 3 week test campaign started on July the 8th, 2022. The DTT TF SULTAN sample was made of two Nb3Sn cable-in-conduit conductor ‘legs’, namely ‘TF-A’ and ‘TF-B’, made with wires produced by Kiswire Advanced Technology, differing for the cabling twist pitch sequence only, and designed to work in DTT at 42.5 kA at 11.9 T peak field. The extensive characterization comprised 3000 electro-magnetic (EM) cycles and two warm-up-cool-down (WUCD) steps, and in detail it included: AC measurements on the virgin conductors, on cyclic loaded conductors and after WUCDs; DC tests at 10.85 T/42.5 kA with intermediate EM cycles at 10.85 T/45 kA before and after WUCDs; DC tests using partial Lorentz force loads, and Minimum Quench Energy tests at 9 T/42.5 kA after cycles and WUCDs. The results of the DC measurement analysis verified the design, in terms of current sharing temperature (T
cs) and critical current (I
c), as both samples are over the minimum acceptance values. In particular, the ‘TF-A’ sample, characterized by a so-called ‘long twist pitch’ cabling sequence, showed higher performance without any degradation with loading and WUCD cycles, whereas sample ‘TF-B’ presented an initial T
cs reduction that afterwards substantially remained unchanged. In terms of strain acting at the Nb3Sn filaments level, this result can be described by a lower effective strain in the ‘TF-A’ sample. AC losses were measured with a calorimetric method as a function of frequency for each series of AC sinusoidal pulsing measurements, and the characteristic coupling time constants were determined.
Computational deconvolution of DNA methylation data from mixed DNA samples
Authors: Ferro dos Santos Maísa R , Giuili Edoardo , De Koker Andries , Everaert Celine , De Preter Katleen 
Published: May 2024

Abstract
In this review, we provide a comprehensive overview of the different computational tools that have been published for the deconvolution of bulk DNA methylation (DNAm) data. Here, deconvolution refers to the estimation of cell-type proportions that constitute a mixed sample. The paper reviews and compares 25 deconvolution methods (supervised, unsupervised or hybrid) developed between 2012 and 2023 and compares the strengths and limitations of each approach. Moreover, in this study, we describe the impact of the platform used for the generation of methylation data (including microarrays and sequencing), the applied data pre-processing steps and the used reference dataset on the deconvolution performance. Next to reference-based methods, we also examine methods that require only partial reference datasets or require no reference set at all. In this review, we provide guidelines for the use of specific methods dependent on the DNA methylation data type and data availability.
MSI-DTI: predicting drug-target interaction based on multi-source information and multi-head self-attention
Authors: Zhao Wenchuan , Yu Yufeng , Liu Guosheng , Liang Yanchun , Xu Dong , Feng Xiaoyue , Guan Renchu 
Published: May 2024

Abstract
Identifying drug-target interactions (DTIs) holds significant importance in drug discovery and development, playing a crucial role in various areas such as virtual screening, drug repurposing and identification of potential drug side effects. However, existing methods commonly exploit only a single type of feature from drugs and targets, suffering from miscellaneous challenges such as high sparsity and cold-start problems. We propose a novel framework called MSI-DTI (Multi-Source Information-based Drug-Target Interaction Prediction) to enhance prediction performance, which obtains feature representations from different views by integrating biometric features and knowledge graph representations from multi-source information. Our approach involves constructing a Drug-Target Knowledge Graph (DTKG), obtaining multiple feature representations from diverse information sources for SMILES sequences and amino acid sequences, incorporating network features from DTKG and performing an effective multi-source information fusion. Subsequently, we employ a multi-head self-attention mechanism coupled with residual connections to capture higher-order interaction information between sparse features while preserving lower-order information. Experimental results on DTKG and two benchmark datasets demonstrate that our MSI-DTI outperforms several state-of-the-art DTIs prediction methods, yielding more accurate and robust predictions. The source codes and datasets are publicly accessible at https://github.com/KEAML-JLU/MSI-DTI.
Gastric conduit reconstruction after esophagectomy
Authors: Watanabe Masayuki , Takahashi Naoki , Tamura Masahiro , Terayama Masayoshi , Kuriyama Kengo , Okamura Akihiko , Kanamori Jun , Imamura Yu 
Published: May 2024

SummaryA high risk of complications still accompanies gastric conduit reconstruction after esophagectomy. In this narrative review, we summarize the technological progress and the problems of gastric conduit reconstruction after esophagectomy. Several types of gastric conduits exist, including the whole stomach and the narrow gastric tube. The clinical outcomes are similar between the two types of conduits. Sufficient blood supply to the conduit is mandatory for a successful esophageal reconstruction. Recently, due to the availability of equipment and its convenience, indocyanine green angiography has been rapidly spreading. When the blood perfusion of the planning anastomotic site is insufficient, several techniques, such as the Kocher maneuver, pedunculated gastric tube with duodenal transection, and additional microvascular anastomosis, exist to decrease the risk of anastomotic failure. There are two different anastomotic sites, cervical and thoracic, and mainly two reconstructive routes, retrosternal and posterior mediastinal routes. Meta-analyses showed no significant difference in outcomes between the anastomotic sites as well as the reconstructive routes. Anastomotic techniques include hand-sewn, circular, and linear stapling. Anastomoses using linear stapling is advantageous in decreasing anastomosis-related complications. Arteriosclerosis and poorly controlled diabetes are the risk factors for anastomotic leakage, while a narrow upper mediastinal space and a damaged stomach predict leakage. Although standardization among the institutional team members is essential to decrease anastomotic complications, surgeons should learn several technical options for predictable or unpredictable intraoperative situations.