bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dexamethasone administration transiently increases insulin response to an oral carbohydrate challenge in horses
Authors: Bertin François-René , van Eps Andrew W. , de Tonnerre Demia J. , Kulp Jaeneen C. , Stefanovski Darko 
Published: February 2025

Abstract

Objective
Dexamethasone is used to experimentally induce insulin resistance; however, its impact on insulin secretion is unclear. This study aimed to assess the responses to oral carbohydrate challenges in dexamethasone-treated horses.

Methods
8 healthy Standardbreds received 0.08 mg/kg of dexamethasone IM every 48 hours for 14 days in June 2022 (winter in the Southern hemisphere). Oral glucose tests (OGT) were conducted before treatment (day 1) and on days 8 and 15. Glucose, insulin, triglycerides, total and active glucagon-like peptide-1 (tGLP-1 and aGLP-1) and glucose-dependent insulinotropic polypeptide (GIP) were measured at baseline and at intervals up to 240 minutes after OGT. The results were analyzed using a mixed-effects linear regression model.

Results
After 8 days of dexamethasone, significant increases in areas under the curve (AUC) of glucose (effect size, +139.1 [95% CI, 124.0 to 154.1] mg/dL·min), insulin (+297.6 [95% CI, 214.6 to 380.8] µIU/mL·min), triglycerides (+4,854.3 [95% CI, 2,181.3 to 7,527.3] mg/dL·min), tGLP-1 (+2.58 [95% CI, 0.23 to 4.93] pmol/L·min), and GIP (+65.56 [95% CI, 40.98 to 90.16] pg/mL·min) were detected post-OGT. These effects were blunted by day 15, with glucose, insulin, and active glucagon-like peptide-1 AUC significantly lower than on day 8 and tGLP-1, triglycerides, and GIP AUC not different from day 1. No horse developed clinical laminitis.

Conclusions
Dexamethasone increased insulin secretion after an OGT with higher lipid mobilization and stimulation of the enteroinsular axis, but the effect was partially reversed by day 15.

Clinical Relevance
While dexamethasone induces insulin resistance consistently over prolonged periods, its effect on insulin secretion seems transient.
Effectiveness of Manual Joint Mobilization Techniques in the Treatment of Nonspecific Neck Pain: Systematic Review With Meta-Analysis and Meta-Regression of Randomized Controlled Trials
Authors: Benetton Alessia , Battista Simone , Bertoni Gianluca , Rossettini Giacomo , Maistrello Luca Falsiroli 
Published: February 2025

OBJECTIVE: The purpose of this study was to investigate the effects of cervical joint mobilization techniques (JMTs) on pain and disability in adults with nonspecific neck pain. DESIGN: This study is an intervention systematic review with meta-analysis and meta-regression of randomized controlled trials (RCTs). LITERATURE SEARCH: We searched MEDLINE, Cochrane CENTRAL, EMBASE, Cumulative Index to Nursing and Allied Health Literature, Physiotherapy Evidence Database, and Web of Science databases, including references from other reviews or clinical practice guidelines up to October 16, 2024. STUDY SELECTION CRITERIA: Eligible RCTs evaluated JMTs compared to routine physiotherapy, minimally active interventions, or no treatment. The primary outcome was pain; secondary outcomes were disability, Global Perceived Effect (GPE), quality of life, psychosocial status, and adverse events. DATA SYNTHESIS: Meta-analyses and meta-regression were conducted for pain, disability, and GPE. The risk of bias was assessed with Cochrane RoB 2.0 Tool; the certainty of the evidence was assessed with the Grading of Recommendations, Assessment, Development, and Evaluations approach. We used The Template for the Intervention Description and Replication checklist to evaluate the quality of reporting of interventions delivered. RESULTS: Results from 16 RCTs were pooled ( n = 1,157 participants), reporting nonclinically positive results on pain reduction (mean difference [MD] = −0.86 (95% confidence interval [−1.35, −0.36])), disability (MD=−2.11 [−3.31, −0.91]), and GPE (standardized mean difference = 0.11 ([−0.15, 0.37]) and high heterogeneity. The meta-regressions did not identify any covariates associated with the treatment effects. Minor side effects (increased neck pain and headache) were reported. CONCLUSION: There was very low certainty evidence supporting the efficacy of JTMs for reducing pain and improving disability in people with NSNP. J Orthop Sports Phys Ther 2025;55(3):1-20. Epub 12 February 2025. doi:10.2519/jospt.2025.12836
Suppression of regulatory factor X 7 alleviates airway remodeling and inflammation in childhood asthma
Authors: Wu Yahui , Dai Tiansheng , Qin Jingwen , Guo Jian , Fan Jitao , Mei Jun , Li Xiaoli , Liu Fang 
Published: February 2025

Objective:
Childhood asthma is a chronic heterogeneous syndrome composed of distinct disease entities or phenotypes. This study was conducted to characterize regulatory factor X 7 (RFX7) in childhood asthma.

Material and Methods:
Two available transcriptome datasets (GSE65204 and GSE27011) were used to analyze regulatory factor X (RFX) family members in childhood asthma. Random forest, logistic regression, and linear support vector machine (SVM) analyses were performed to construct an RFX-based classification model. Airway smooth muscle cells (ASMCs) were induced through platelet-derived growth factor-BB (PDGF-BB) for an asthma in vitro model. RFX7 expression was measured through immunoblotting. RFX7 was knocked out by transfection of RFX7 small-interfering RNAs, and then airway remodeling and inflammation were assayed.

Results:
Among RFX family members, RFX3, RFX7, and RFX-associated protein displayed differential expression in childhood asthma versus healthy controls. Thus, SVM, logistic regression, and random forest-based machine learning models were built. The random forest model presented the best diagnostic efficacy (area under the curve [AUC] = 1 and 0.67 in discovery and verification sets). RFX7 was found to be effective in diagnosing childhood asthma (AUC = 0.724 and 0.775 in discovery and verification sets). In addition, RFX7 was overexpressed in PDGF-BB-stimulated ASMCs (✶✶P < 0.01). Silencing RFX7 remarkably attenuated the proliferative and migrative capacities of ASMCs with PDGF-BB stimulation (✶✶P < 0.01). In addition, RFX7 was positively related to neutrophil infiltration in childhood asthma, and its knockdown downregulated the levels of pro-inflammatory cytokines in PDGF-BB-stimulated ASMCs (✶✶P < 0.01).

Conclusion:
The findings of this study indicate that RFX7 is a novel molecule that is correlated with airway remodeling and inflammation in childhood asthma, providing insights into the mechanism underlying this disease and its potential clinical importance.
ELEMENTARY THEORETICAL MODEL OF THERMAL BREAKDOWN GENERATION IN SEMICONDUCTOR FILM
Authors: ANDREYEVA N.V. , VIRCHENKO YU.P. 
Published: February 2025

It is proposed an elementary theory of thermal breakdown of functional element in electrical circuit. It is represented in the form of the film on the basis of semiconductor material. The theory is based on a simple mathematical model which takes into account the balance of heat between thermal channels originated temperature deviations. Each of them is a self-consistent heat source due to an electric current flowing through the film. Such channels located perpendicular to the film. The positive feedback between the heating of the thermal channel and the current growth in it leads to superfast growth of the temperature in such a channel up to the melting temperature. Such an evolution process is interpreted as a thermal breakdown of the material. It leads to the formation of melting channels with small diameter which are directed through the film. In turn, it leads to degradation of the electrical properties of the material.
Предложена элементарная теория теплового разрушения функционального элемента в электрической цепи. Она представлена в виде пленки на основе полупроводникового материала. Теория основана на простой математической модели, которая учитывает баланс тепла между тепловыми каналами, возникающий при отклонениях температуры. Каждый из них является автономным источником тепла за счет электрического тока, протекающего через пленку. Такие каналы расположены перпендикулярно пленке. Положительная обратная связь между нагревом теплового канала и ростом тока в нем приводит к сверхбыстрому росту температуры в таком канале вплоть до температуры плавления. Такой эволюционный процесс интерпретируется как термическое разрушение материала. Это приводит к образованию каналов плавления небольшого диаметра, которые проходят сквозь пленку. В свою очередь, это приводит к ухудшению электрических свойств материала.
СМЕШАННАЯ КРАЕВАЯ ЗАДАЧА ДЛЯ ОБОБЩЕННОГО УРАВНЕНИЯ ЛАПЛАСА
Authors: МАСАЕВА О.Х. 
Published: February 2025

В работе исследована краевая задача с граничными условиями первого и второго рода на границе области для дифференциального уравнения в частных производных второго порядка. Рассматриваемое уравнение – уравнение с дробной производной Римана-Лиувилля по одной из двух независимых переменных порядка меньшего двух, большего единицы, совпадает с уравнением Лапласа, когда порядок дробного дифференцирования равен двум. Рассмотрены вопросы доказательства существования и единственности регулярного решения задачи. Приведены теоремы, иллюстрирующие полученные результаты.
The paper investigates a boundary value problem with boundary conditions of the first and second kind on the boundary of the domain for a second-order partial differential equation. The equation under consideration is an equation with a fractional Riemann-Liouville derivative with respect to one of the two independent variables of an order less than two and greater than one, and coincides with the Laplace equation when the order of fractional differentiation is two. The issues of proving the existence and uniqueness of a regular solution to the problem are considered. Theorems illustrating the results obtained are presented.
ЕВРОПЕЙСКАЯ ЛЕГЕНДА О ШЕЙХЕ МАНСУРЕ. ИСТОРИЯ ОДНОЙ МИСТИФИКАЦИИ
Authors: СОКОЛОВ А.Р. , УМАРОВ Д.В. 
Published: February 2025

В статье рассматривается популярная в западной историографии версия о тождестве предводителя народно-освободительного движения кавказских горцев имама Мансура и итальянского авантюриста Джованни Боэтти. На основе широкого круга источников авторы опровергают эту легенду и анализируют причины ее возникновения, а также востребованности в настоящее время.
The article examines the version popular in Western historiography about the identity of the leader of the liberation vision of the Caucasian highlanders, Imam Mansour, and the Italian adventurer Giovanni Boetti. Based on a wide range of sources, the authors refutes this legend and analyzes the reasons for its occurrence, as well as its relevance at the present time.
К ВОПРОСУ ОБ ОБРЯДЕ ПОГРЕБЕНИЯ НАСЕЛЕНИЯ ПРЕДГОРИЙ ЧЕЧНИ В ФИНАЛЕ РАННЕГО БРОНЗОВОГО ВЕКА
Authors: БУРКОВ С.Б. 
Published: February 2025

В статье рассматриваются основные черты, свойственные погребально-церемониальной практике племен, обитавших в предгорных районах Чечни в конце ранней бронзы и на начальном этапе среднего бронзового века. К исследованию привлечен обширный материал с прилегающих территорий, учитываются и сведения по предгорно-горной зоне Восточного Предкавказья. В произведенных нами исследованиях важную роль играют ранее не использованные архивные материалы, а также результаты авторских раскопок на левобережье среднего течения рек Ассы и Фортанга. В итоге удается установить, какие культурные группы и в каком качестве приняли участие в формировании новых элементов погребальной обрядности следующей исторической эпохи.
The article examines the main features of funerary and ceremonial practices of tribes living in the Chechen foothills at the end of the Early Bronze Age and at the beginning of the Middle Bronze Age. Extensive materials from the adjacent territories have been brought to bear on the research, and data from the foothill-mountain zone of the Eastern Precaucasus is also taken into account. The previously unused archival materials and the results of the author's excavations on the left bank of the middle reaches of the Assa and Fortanga rivers play an important role in the study As a result, it is possible to establish which cultural groups and in what capacity took part in the formation of new elements of funerary rites of the next historical epoch.
Bunuh Diri dalam Tiga Novel Indonesia: Perspektif Psikologi Kematian
Authors: Ahmadi Anas , Supratno Haris , Parmin Parmin 
Published: February 2025

Abstract This study explores the suicidal desire and behavior of modern humans
found in Indonesian literature. So far, research on suicidal ideation and behavior tends
to be mostly done in the realm of psychology. Unfortunately, research on suicidal
ideation and behavior from the perspective of the psychology of death is still not
widely carried out by researchers in the field of literature. In this regard, this study
raises the desire and suicidal behavior of modern humans as reflected in Indonesian
literature. The method used in this research is qualitative using data sources from
three Indonesian novels, Olenka, Rafilus, and Supernova. The data collection technique
was carried out in a documentary manner referring to the text data contained in the
novel. The data analysis technique uses the stages of identification, classification,
and exposure to research data. The results of the study show the following. First, the
novel Olenka, Rafilus, and Supernova depicts a character who narrates a suicide
committed by another person and he feels how the suicide happened. Second, suicide is
contained in the character's mind as a responsibility of human freedom. Third, suicide
appears in the flash of the character's mind. Keywords: desire, behavior, suicide,
literature, psychology of death
KOMPONEN GRAMATIKA DALAM PEMBELAJARAN BAHASA INDONESIA BERBASIS TEKS DI SMA
Authors: SUTAMA I MADE , RAMENDRA DEWA PUTU , NURJAYA I GEDE 
Published: February 2025

Abstract When the 2013 Curriculum and text-based teaching of Indonesian were
implemented, teaching of grammar was given a special portion. Its existence in textbooks
is interesting to study because this is the latest development in the position of
grammar in teaching Indonesian. Therefore, the research problem of how the existence of
a grammatical component in SMA Indonesian textbooks is formulated. This research used a
qualitative design to solve the research problem. The data source is the Indonesian
textbook for senior high school published by the Ministry of Education and Culture in
2016. The data collection method used is documentation. The data analysis model of Miles
and Huberman will process the obtained data. The results of the study show the following
things. Of the 22 materials on text distributed into three books, 20 contain grammatical
components. The rest that did not include the grammatical units was poetry text material
in class X and novel text material in class XII. Twenty materials on texts have
grammatical components consisting of 19 materials of untheoretical explanations of the
existing grammatical items. The other has thorough material on the text of the
observation report in the textbook for class X. Meanwhile, the twenty materials on texts
that contain grammatical components have provide examples and exercises related to the
existing grammatical items.Keywords: grammatical component, learning, text-based
Abstrak Ketika Kurikulum 2013 dan pengajaran bahasa Indonesia berbasis teks diterapkan,
pengajaran gramatika diberikan porsi khusus. Keberadaannya dalam buku pelajaran menarik
untuk dikaji karena ini merupakan perkembangan terakhir posisi gramatika dalam
pengajaran bahasa Indonesia. Oleh karena itu, masalah penelitian tentang bagaimana
keberadaan komponen gramatika dalam buku teks bahasa Indonesia SMA dirumuskan. Desain
kualitatif digunakan untuk menjawab masalah penelitian. Sumber data penelitian ini
adalah buku teks Bahasa Indonesia SMA terbitan Kemendikbud (2016). Metode pengumpulan
data yang digunakan adalah dokumentasi. Data yang diperoleh kemudian diolah dengan model
analisis data dari Miles dan Hubberman. Hasil penelitian menunjukkan hal-hal sebagai
berikut. Dari 22 materi teks yang didistribusikan ke dalam tiga buku, dua puluh materi
mengandung komponen gramatika. Dua materi yang tidak mengandung komponen gramatika,
yaitu materi teks puisi di kelas X dan materi teks novel di kelas XII. Dari 20 materi
teks yang mengandung komponen gramatika, terdapat 19 materi yang tidak menyertakan
penjelasan teoretis dari butir gramatika yang ada dan hanya satu yang berisi penjelasan,
yaitu materi pada teks laporan hasil observasi yang ada di dalam buku ajar kelas X.
Sementara itu, 20 materi pada teks yang mengandung komponen gramatika memberikan contoh
dan latihan yang berkaitan dengan butir-butir gramatika yang ada. Kata-kata kunci:
komponen gramatika, pembelajaran, berbasis teks
FIGUR IBU PADA CERPEN “REMBULAN DI MATA IBU” KARYA ASMA NADIA
Authors: Zalmansyah Achril , Irawan Yoga , Fitriani Annisa 
Published: February 2025

Abstract The mother figure has always been an inspiration in writing literary
works in Indonesia. One is the short story "Rembulan di Mata Ibu" by Asma Nadia. This
paper intends to explain and analyze the mother figure and what factors shape the
mother’s character in the short story. The method used is a qualitative method. The data
were taken from the short story "Rembulan di Mata Ibu" by Asma Nadia in 2002. The
results showed a change in character experienced by the mother. In the beginning,
Mother’s image is a conventional character. However, at the end of the story, the
picture of Mother is a far-sighted character. The five characters appeared in the mother
figure, namely a strong figure, a fierce and selfish figure, a restrained figure, a
person who was not open-minded, and affectionate figure. Two factors that shape the
mother's character are economic factors and family factors. Keywords: Mother, Short
Story, Rembulan di Mata Ibu Abstrak Figur ibu selalu menjadi insipirasi dalam
penulisan karya sastra di Indonesia. Salah satunya adalah cerpen “Rembulan di Mata Ibu’
karya Asma Nadia. Tulisan ini bermaksud menjelaskan dan menganalisis figur ibu dan
faktor-faktor apa saja yang membentuk karakter tokoh ibu dalam cerpen tersebut. Metode
yang digunakan dalam penelitian ini adalah metode kualitatif. Data diambil dari cerpen
“Rembulan di Mata Ibu” karya Asma Nadia tahun 2002. Hasil penelitian menunjukkan ada
perubahan karakter yang dialami oleh Ibu. Di awal cerita, Ibu digambarkan sebagai tokoh
yang konvensional. Namun di akhir cerita, Ibu digambarkan sebagai tokoh yang berpikiran
jauh ke depan. Ada lima karakter yang muncul pada sosok ibu, yaitu sosok yang kuat,
galak dan egois, pengekang, tidak berpikiran terbuka, dan penyayang. Faktor-faktor yang
membentuk karakter ibu ada dua, yaitu faktor ekonomi dan keluarga.Kata-kata Kunci: Ibu,
Cerpen, Rembulan di Mata Ibu, karakter
ANALISIS PSIKOLOGI SASTRA DALAM CERITA ALTERNATE UNIVERSE “BENDERA SETENGAH TIANG”
KARYA @97NISAIURS
Authors: Azzahra Mahesa , Dewi Trie Utari 
Published: February 2025

Abstract Current technological developments influence the development of digital
literature. One popular form of the digital literature among teenagers is Alternate
Universe (AU) genre, entitled "Bendera Setengah Tiang" by @97NISAIURS, which revolves
around hostage situation of university students. Specifically, the aim of this research
is to examine the form of literary psychology in the characters of the Alternate
Universe "Bendera Setengah Tiang" by @97NISAIURS. This research employs a qualitative
descriptive research methodology. As a result of this research, the Id was obtained in
16 instances, including coercive pressure, encouragement of desires through action,
curiosity, yearning for reunification, seeking help, feelings of wanting to protect,
feelings of willingness to sacrifice, worry and hope which are evident in the
characters’ utterances and expressions, as captures in the story’s narrative and quotes.
The Ego is observed in 7 instances, in the form of the determination to sacrifice,
striving to protect others, exercising self-control, optimistic attitude, defensive
actions, refusing to give up, that are evident in the characters’ actions and behaviors,
as depicted in the story’s narrative and quotes. Furthermore, the Superego is revealed
in 3 instances, in the form of sense of empathy, gratitude, a drive to fight, and
feelings of guilt experienced by the characters as captured in the story’s narrative and
quotes. Keywords: Psychology of Literature, Alternate Universe, Bendera Setengah Tiang.
Abstrak Perkembangan teknologi saat ini memengaruhi perkembangan sastra digital.
Salah satu sastra digital yang digemari kalangan remaja terdapat pada Alternate Universe
(AU) berjudul “Bendera Setengah Tiang” karya @97NISAIURS, berkisahkan tentang
penyanderaan mahasiswa. Tujuan pada penelitian ini tepatnya untuk mendeskripsikan bentuk
psikologi sastra dalam karakter tokoh pada Alternate Universe “Bendera Setengah Tiang”
karya @97NISAIURS. Penelitian ini mengenakan metode penelitian deskriptif kualitatif.
Penelitian ini menghasilkan aspek Id yang berjumlah 16 data, berupa tekanan paksaan,
dorongan keinginan melalui tindakan, rasa ingin tahu, perasaan rindu ingin bertemu, rasa
membutuhkan pertolongan, rasa ingin melindungi, rasa rela berkorban, rasa khawatir, dan
rasa berharap, dari ungkapan atau pernyataan para tokoh yang dapat terlihat dari narasi
dan kutipan dalam cerita. Ego berjumlah dengan 7 data, berupa tekad berkorban, usaha
melindungi, usaha menahan diri, sikap optimis, tindakan bertahan, perilaku pantang
menyerah, yang dialami para tokoh, terbukti dari narasi dan kutipan dalam cerita. Selain
itu, Superego berjumlah 3 data, berupa rasa haru dan rasa syukur serta kesadaran untuk
berjuang dan perasaan bersalah yang dialami para tokoh yang terdapat pada narasi dan
kutipan dalam cerita. Kata-kata kunci: Psikologi Sastra, Alternate Universe, Bendera
Setengah Tiang.
Системи підбору кваліфікованих медичних фахівців з онкології на основі аналізу медичних даних
Authors: Кучерук Ольга Віталіївна , Желізко Віктор Вікторович , Марчук Галина Вікторівна , Коротун Ольга Володимирівна 
Published: February 2025

За останні роки системи підтримки прийняття рішень стали критично важливими в сфері охорони здоров’я, надаючи допомогу працівникам медицини в прийнятті обґрунтованих рішень. У статті досліджується роль алгоритмів дерева рішення як одного з провідних методів у системах підтримки прийняття рішень, наголошуючи на їх ефективності в задачах класифікації та прогнозування. Дерева рішень мають кілька переваг, враховуючи інтуїтивну структуру, простоту інтерпретації та можливість надавати чіткі пояснення поряд із точними результатами. Також дерева рішень відзначаються здатністю видобувати значущі правила з комплексних наборів даних, що сприяє виявленню прихованих закономірностей, які можуть бути неочевидними за допомогою традиційних аналітичних методів. У статті підкреслюється універсальність дерев рішень, що робить їх особливо придатними для широкого спектра медичних застосувань, таких як пошук найбільш підходящого лікаря, встановлення діагнозу та методів лікування. Така можливість значно покращує процеси прийняття клінічних рішень, дозволяючи забезпечити більш індивідуалізовану та ефективну медичну допомогу. Оскільки охорона здоров’я дедалі більше впроваджує рішення, засновані на даних, інтеграції алгоритмів дерева рішень у системі підтримки прийняття рішень, ймовірно, принесе значні переваги, покращуючи якість медичної практики та, врешті-решт, призводячи до кращих показників здоров’я пацієнтів. У статті робиться висновок про необхідність подальшого розвитку та застосування алгоритмів дерева рішень у медичних установах, підкреслюючи їх потенціал революціонізувати прийняття медичних рішень і системи підтримки в досягненні поліпшення показників здоров’я та вибору лікаря-онколога.