bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radiomics-Based Analysis of Intestinal Ultrasound Images for Inflammatory Bowel Disease: A Feasibility Study
Authors: Gu Phillip , Chang Jui-Hsuan , Carter Dan , McGovern Dermot P B , Moore Jason , Wang Paul , Huang Xiuzhen 
Published: May 2024

Abstract

Background
The increasing adoption of intestinal ultrasound (IUS) for monitoring inflammatory bowel diseases (IBD) by IBD providers has uncovered new challenges regarding standardized image interpretation and limitations as a research tool. Artificial intelligence approaches can help address these challenges. We aim to determine the feasibility of radiomic analysis of IUS images and to determine if a radiomics-based classification model can accurately differentiate between normal and abnormal IUS images. We will also compare the radiomic-based model’s performance to a convolutional neural network (CNN)-based classification model to understand which method is more effective for extracting meaningful information from IUS images.

Methods
Retrospectively analyzing IUS images obtained during routine outpatient visits, we developed and tested radiomic-based and CNN-based models to distinguish between normal and abnormal images, with abnormal images defined as bowel wall thickness &gt; 3 mm or bowel hyperemia with modified Limberg score ≥ 1 (both are surrogate markers for inflammation). Model performances were measured by area under the receiver operator curve (AUC).

Results
For this feasibility study, 125 images (33% abnormal) were analyzed. A radiomic-based model using XG boost yielded the best classifier model with average test AUC 0.98%, 93.8% sensitivity, 93.8% specificity, and 93.7% accuracy. The CNN-based classification model yielded an average testing AUC of 0.75.

Conclusions
Radiomic analysis of IUS images is feasible, and a radiomic-based classification model could accurately differentiate abnormal from normal images. Our findings establish methods to facilitate future radiomic-based IUS studies that can help standardize image interpretation and expand IUS research capabilities.
Safety and Effectiveness of Ustekinumab for Crohn’s Disease With Perianal Manifestations: Ad hoc Analysis Data From 1-Year Post-Marketing Surveillance Study in Japan
Authors: Nagano Katsumasa , Tsuchiya Hiroaki , Asano Teita , Yamazaki Hiroshi , Tominaga Sonoko , Matsumoto Takayuki 
Published: May 2024

Abstract

Background
Crohn’s disease (CD) is an immune-mediated inflammatory disorder of the gastrointestinal tract with perianal disease being one of the challenging possible manifestations. Here, we report, an ad hoc analysis of the safety and effectiveness of 1-year use of ustekinumab (UST) for CD in patients with perianal manifestations using post-marketing surveillance (PMS) data in Japan.

Methods
Among 341 patients enrolled in the PMS, 229 and 224 patients who had baseline Crohn’s Disease Activity Index (CDAI) data used for evaluating perianal manifestations were included in the safety and efficacy analysis sets, respectively. Incidence of adverse drug reactions, clinical remission, the mean or its change in CDAI scores, and CDAI items were evaluated through week 52 in the presence or absence of perianal manifestations at baseline. The prevalence of perianal manifestations was also described.

Results
Comparing patients with and without baseline perianal manifestations at week 52, there was no difference in ADR incidence (9.1% [n = 66] vs. 15.3% [n = 163]), no difference in clinical remission (68.3% vs. 59.9%; P = 0.269), and decreased mean change of CDAI score (−82.9 [n = 60] vs. −68.8 [n = 137]). The proportion of patients with perianal manifestations decreased after UST treatment in both biologics-naïve patients (23.5% [n = 4/17]) and patients who had received biologics (35.0% [n = 14/40]) at week 52.

Conclusions
In Japanese clinical practice, UST is safe and effective in CD patients with and without perianal manifestations. The therapy might be also beneficial in those with manifestations regardless of prior use of other biologics.
Genome-wide DNA Methylome and Transcriptome Profiling Reveals Key Genes Involved in the Dysregulation of Adipose Stem Cells in Crohn’s Disease
Authors: Monfort-Ferré Diandra , Boronat-Toscano Albert , Sánchez-Herrero José-Francisco , Caro Aleidis , Menacho Margarita , Vañó-Segarra Irene , Martí Marc , Espina Beatriz , Pluvinet Raquel , Cabrinety Lidia , Abadia Carme , Ejarque Miriam , Nuñez-Roa Cati , Maymo-Masip Elsa , Sumoy Lauro , Vendrell Joan , Fernández-Veledo Sonia , Serena Carolina 
Published: May 2024

Abstract

Background and Aims
Crohn’s disease [CD] is characterised by the expansion of mesenteric adipose tissue [MAT], named creeping fat [CF], which seems to be directly related to disease activity. Adipose-stem cells [ASCs] isolated from the CF of patients with CD are extremely pro-inflammatory, which persists during disease remission. We hypothesised that the dysfunctional ASCs in CD accumulate epigenetic modifications triggered by the inflammatory environment, that could serve as molecular markers.

Methods
Genome-wide DNA methylome and transcriptome profiling were performed in ASCs isolated from MAT biopsies of patients with active and inactive disease and from non-Crohn’s disease patients [non-CD]. A validation cohort was used to test the main candidate genes via quantitative polymerase chain reaction in other fat depots and immune cells.

Results
We found differences in DNA methylation and gene expression between ASCs isolated from patients with CD and from non-CD subjects, but we found no differences related to disease activity. Pathway enrichment analysis revealed that oxidative stress and immune response were significantly enriched in active CD, and integration analysis identified MAB21L2, a cell fate-determining gene, as the most affected gene in CD. Validation analysis confirmed the elevated gene expression of MAB21L2 in MAT and in adipose tissue macrophages in active CD. We also found a strong association between expression of the calcium channel subunit gene CACNA1H and disease remission, as CACNA1H expression was higher in ASCs and MAT from patients with inactive CD, and correlates negatively with C-reactive protein in peripheral blood mononuclear cells.

Conclusion
We identified a potential gene signature of CD in ASCs obtained from MAT. Integration analysis highlighted two novel genes demonstrating a negative correlation between promoter DNA methylation and transcription: one linked to ASCs in CD [MAB21L2] and the other [CACNA1H] related to disease remission.
Sequential trait evolution did not drive deep-time diversification in sharks
Authors: Marion Alexis F P , Condamine Fabien L , Guinot Guillaume 
Published: May 2024

Abstract
Estimating how traits evolved and impacted diversification across the tree of life represents a critical topic in ecology and evolution. Although there has been considerable research in comparative biology, large parts of the tree of life remain underexplored. Sharks are an iconic clade of marine vertebrates, and key components of marine ecosystems since the early Mesozoic. However, few studies have addressed how traits evolved or whether they impacted their extant diversity patterns. Our study aimed to fill this gap by reconstructing the largest time-calibrated species-level phylogeny of sharks and compiling an exhaustive database for ecological (diet, habitat) and biological (reproduction, maximum body length) traits. Using state-of-the-art models of evolution and diversification, we outlined the major character shifts and modes of trait evolution across shark species. We found support for sequential models of trait evolution and estimated a small to medium-sized lecithotrophic and coastal-dwelling most recent common ancestor for extant sharks. However, our exhaustive hidden traits analyses do not support trait-dependent diversification for any examined traits, challenging previous works. This suggests that the role of traits in shaping sharks’ diversification dynamics might have been previously overestimated and should motivate future macroevolutionary studies to investigate other drivers of diversification in this clade.
Quorum sensing-related activities of beneficial and pathogenic bacteria have important implications for plant and human health
Authors: Hartmann Anton , Binder Tatiana , Rothballer Michael 
Published: May 2024

Abstract
Eukaryotic organisms coevolved with microbes from the environment forming holobiotic meta-genomic units. Members of host-associated microbiomes have commensalic, beneficial/symbiotic, or pathogenic phenotypes. More than 100 years ago, Lorenz Hiltner, pioneer of soil microbiology, introduced the term ‘Rhizosphere’ to characterize the observation that a high density of saprophytic, beneficial, and pathogenic microbes are attracted by root exudates. The balance between these types of microbes decide about the health of the host. Nowadays we know, that for the interaction of microbes with all eukaryotic hosts similar principles and processes of cooperative and competitive functions are in action. Small diffusible molecules like (phyto)hormones, volatiles and quorum sensing signals are examples for mediators of interspecies and cross-kingdom interactions. Quorum sensing of bacteria is mediated by different autoinducible metabolites in a density-dependent manner. In this perspective publication, the role of QS-related activities for the health of hosts will be discussed focussing mostly on N-acyl-homoserine lactones (AHL). It is also considered that in some cases very close phylogenetic relations exist between plant beneficial and opportunistic human pathogenic bacteria. Based on a genome and system-targeted new understanding, sociomicrobiological solutions are possible for the biocontrol of diseases and the health improvement of eukaryotic hosts.
The majority of fact-checking labels in the United States are intense and this decreases engagement intention
Authors: Xue Haoning , Zhang Jingwen , Shen Cuihua , Wojcieszak Magdalena 
Published: May 2024

Abstract
Fact-checking labels have been widely accepted as an effective misinformation correction method. However, there is limited theoretical understanding of fact-checking labels’ impact. This study theorizes that language intensity influences fact-checking label processing and tests this idea through a multi-method design. We first rely on a large-scale observational dataset of fact-checking labels from 7 U.S. fact-checking organizations (N = 33,755) to examine the labels’ language intensity and then use a controlled online experiment in the United States (N = 656) to systematically test the causal effects of fact-checking label intensity (low, moderate, or high) and fact-checking source (professional journalists or artificial intelligence) on perceived message credibility of and the intention to engage with fact-checking messages. We found that two-thirds of existing labels were intense. Such high-intensity labels had null effects on messages’ perceived credibility, yet decreased engagement intention, especially when labels were attributed to AI. Using more intense labels may not be an effective fact-checking approach.
Optimizing patient outcomes: the impact of multimodal preemptive analgesia in video-assisted thoracoscopic lobectomy
Authors: Li Bing , Chen Yu , Ma Rong 
Published: May 2024

Abstract

OBJECTIVES
The aim of this study was to evaluate the efficacy of a multimodal preemptive analgesia management approach, specifically incorporating ultrasound-guided thoracic paravertebral block (UG-TPVB) in conjunction with intravenous analgesia, after video-assisted thoracoscopic (VATS) lobectomy under the guidance of enhanced recovery after surgery.

METHODS
A total of 690 patients who underwent VATS lobectomy between October 2021 and March 2022 were divided into the UG-TPVB group (group T, n = 345) and the control group (group C, n = 345). Patients in group T received UG-TPVB prior to the induction of general anaesthesia, while group C did not undergo nerve block. A comparison was conducted between the 2 groups regarding various indicators, including postoperative sedation, static/dynamic numeric rating scale scores, intraoperative fentanyl consumption, duration of mechanical ventilation/anaesthesia recovery/hospitalization, postoperative complications and other relevant factors.

RESULTS
The static/dynamic numeric rating scale scores of group T were lower than those of group C after surgery. Intraoperative fentanyl consumption in group T (0.384 ± 0.095 mg) was lower than that in group C (0.465 ± 0.053 mg). The duration of mechanical ventilation, anaesthesia recovery and hospitalization were significantly shorter in group T compared to group C. Patient satisfaction rate in group T (70.1%) was higher than that in group C (53.6%). All differences were statistically significant (P &lt; 0.05).

CONCLUSIONS
The multimodal preemptive analgesia management strategy effectively reduces postoperative pain, decreases opioid consumption and promotes faster recovery in patients undergoing VATS lobectomy.
Conservative Worldviews and the Climate Publics of New Zealand and Australia
Authors: Crawley Sam 
Published: May 2024

Abstract
Public opinion on climate change is complex, comprising aspects such as belief, support for policies, and issue salience. This multidimensional nature of climate opinion can be accounted for by identifying “publics,” each comprising people with similar climate attitudes. Climate opinion has also been found to relate strongly to political worldviews, with people holding conservative attitudes tending to have low levels of engagement with climate change. However, few studies have investigated how political worldviews relate to membership of climate publics. The current study therefore identifies climate publics in New Zealand and Australia and investigates how they relate to economic and social aspects of conservative worldviews. Using an original online survey, I find no clear link between economic conservatism and membership of climate publics. Social conservatives, however, are more likely to be members of publics with low levels of climate engagement and of “middle” publics, which accept the science of climate change but are “lukewarm” on climate action. Climate opinion appears to be more polarized in Australia than New Zealand. These results provide insight into the worldviews of people in the “mainstream” of climate opinion and suggest that only a minority of the public are demanding ambitious climate action.
Happy Click!: Investigating the Use of a Tangible Interface to Facilitate the Three Good Things Positive Psychology Intervention
Authors: Siriaraya Panote , Tanaka Ryotaro , She Wan Jou , Jain Rushil , Schok Michaela , De Ruiter Martine , Desmet Pieter , Nakajima Shinsuke 
Published: May 2024

Abstract
The ‘Three Good Things’ (TGT), a structured journaling exercise, has shown great effect in helping improve mental well-being. However, the exercise could be quite tedious and difficult to carry out daily. To improve the user experience of the exercise, we developed ‘Happy Click’, a mobile application which makes use of a physically present smart button to enable users to record their daily TGT in a more engaging manner. Two preliminary exploratory studies were carried out to examine the feasibility of our approach where the effects of the TGT intervention designed around the mobile and tangible happy click concepts were examined. The findings suggested that participants had significantly less stress after carrying out the TGT using the tangible interface. Participants also reported better user experience and acceptance when carrying out the exercise using the tangible interface compared to the mobile and higher levels of attractiveness and stimulation with the mobile TGT compared to the traditional approach. While these promising results should be interpreted with caution due to the limited sample size, they also underscore the potential advantages of our ‘Happy click’ approach and highlight the need for further, larger-scale evaluations to be conducted to validate its efficacy and scalability.
Effect of dietary supplementation with recombinant human lysozyme on growth performance, antioxidative characteristics, and intestinal health in broiler chickens
Authors: Tian Xuefeng , Cao Heng , Yan Juntong , Li Chunyue , Li Feiyu , Li Yunke , Huang Fei , Bao Chengling , Cao Yunhe , Rao Zhenghua 
Published: May 2024

Abstract
Lysozyme is often used as a feed additive to act as an antibacterial protein that boosts the immune system of livestock and poultry while protecting against pathogens. To investigate the effects of recombinant human lysozyme (rhLYZ) from Pichia pastoris and chlortetracycline on broiler chicken’s production performance, antioxidant characteristics, and intestinal microbiota, a total of 200, 1-d-old male Arbor Acres broiler chickens (46.53 ± 0.42 g) were selected for a 42-d experiment. Dietary treatments included a basal diet of corn-soybean meal supplemented with either 0 mg/kg (CON), 50 mg/kg aureomycin (ANT), 20 mg/kg rhLYZ (LOW), 60 mg/kg rhLYZ (MEDIUM), or 180 mg/kg rhLYZ (HIGH). Compared with CON, MEDIUM diet increased (P &lt; 0.05) average daily gain (67.40 g) of broilers from day 22 to 42. In the early (1.29) and overall phases (1.69), MEDIUM led to a reduction (P &lt; 0.05) in the feed conversion ratio of broiler chickens. Furthermore, in comparison to the CON and ANT, MEDIUM exhibited reduced (P &lt; 0.05) levels of INF-γ and tumor necrosis factor-α in the serum. In the cecum, the abundance of Monoglobus and Family_XIII_AD3011_group was lower (P &lt; 0.05) in the MEDIUM treatment compared to CON. Overall, supplementation of 60 mg/kg of rhLYZ improved growth performance, nutrient utilization efficiency, and serum immune function, while also influencing the composition of intestinal microbiota. This suggests lysozyme’s potential to replace antibiotic additives in feed.
Race in Consumer Research: Past, Present, and Future
Authors: Grier Sonya A , Crockett David , Johnson Guillaume D , Thomas Kevin D , Bradford Tonya Williams 
Published: May 2024

Abstract
Race has been a market force in society for centuries. Still, the question of what constitutes focused and sustainable consumer research engagement with race remains opaque. We propose a guide for scholars and scholarship that extends the current canon of race in consumer research toward understanding race, racism, and related racial dynamics as foundational to global markets and central to consumer research efforts. We discuss the nature, relevance, and meaning of race for consumer research and offer a thematic framework that critically categorizes and synthesizes extant consumer research on race along the following dimensions: (1) racial structuring of consumption and consumer markets, (2) consumer navigation of racialized markets, and (3) consumer resistance and advocacy movements. We build on our discussion to guide future research that foregrounds racial dynamics in consumer research and offers impactful theoretical and practical contributions.
Hidden Barriers to Marketplace Disability Accessibility: An Empirical Analysis of the Role of Perceived Trade-Offs
Authors: Grewal Lauren , van der Sluis Helen 
Published: May 2024

Abstract
Disability is a basic human condition that affects a significant proportion of the world’s population, yet many disability- and accessibility-relevant issues remain pressing and insufficiently addressed. With three experiments, the current research investigates potential reasons for why marketplace disability accessibility has not been universally accepted. Potential barriers to greater accessibility in marketplaces may arise because such efforts appear at odds with other salient priorities, at micro (i.e., consumer) and macro (i.e., firm, policy, or societal) levels. In the proposed framework and resulting experiments, micro-level trade-offs prompt perceptions of personal cost and macro-level trade-offs prompt perceptions of firm morality. In turn, these perceptions mediate firm evaluations, showing that consumers at baseline respond negatively to accessibility. Critically, however, several practical interventions emerge from these processes. Marketers can mitigate consumers’ negative responses to accessibility by employing simple framing choices such as emphasizing who benefits or noting what the purpose of the offering is. By demonstrating one way to better understand perceptions of the full spectrum of the consumer population, this research provides pathways for consumer researchers to further delve into disability-related research in the future.
Frequencies of insecticide resistance mutations detected by the amplicon sequencing in Plutella xylostella (Lepidoptera: Plutellidae) and Spodoptera exigua (Lepidoptera: Noctuidae) from China
Authors: Liu Zhangyang , Ma Haihao , Li Kaiqin , Liu Jia , Zhu Hang , Zhou Yong , Man Yilong , Zhou Xiaomao , Liu Zheming 
Published: May 2024

Abstract
The globally prevalent pests, Diamondback moth, Plutella xylostella (Lepidoptera: Plutellidae) and Beet armyworm, Spodoptera exigua (Lepidoptera: Noctuidae), pose significant threats to cruciferous vegetables. They have rapidly developed resistance to a wide range of insecticides, leading to significant yield losses and increased control expenses. In this study, we have established an efficient approach utilizing amplicon sequencing to detect the frequency of 15 target resistance mutant sites in 6 molecular targets, acetylcholinesterase 1 (ACE1), chitin synthase 1 (CHS1), the γ-aminobutyric acid receptor (GABAR), glutamate-gated chloride channel (GluCl), voltage-gated sodium channels (NaV), and ryanodine receptor (RyR) in P. xylostella and the frequency of 11 mutations in 5 molecular targets (except GluCl) in S. exigua in China. Our findings indicate that P. xylostella exhibits remarkably high frequency (over 88.67%) in pyrethroid resistance-related mutations T929I and L1014F of NaV. In S. exigua, the frequencies of L659F mutation were ranging from 41.92% to 74.89%. In addition, the organophosphorus resistance-related mutations A298S and G324A of ACE1 were detected at frequencies ranging from 34.29% to 75.66%, and these 2 mutations occurred simultaneously (from 29.22% to 65.79%) in P. xylostella. An interannual variation in mutation frequency from 2019 to 2021 was found for P. xylostella in HNCS. The frequency of A298S and G324A mutations steadily increased while the frequency of G4946E and I4790M mutations continuously decreased. These results unveil a worrisome scenario of multiple resistance sites in these 2 pests in China and provide valuable insights for the practical application of pesticides in the field.
Estimation of distribution algorithms with solution subset selection for the next release problem
Authors: Pérez-Piqueras Víctor , López Pablo Bermejo , Gámez José A 
Published: May 2024

Abstract
The Next Release Problem (NRP) is a combinatorial optimization problem that aims to find a subset of software requirements to be delivered in the next software release, which maximize the satisfaction of a list of clients and minimize the effort required by developers to implement them. Previous studies have applied various metaheuristics, mostly genetic algorithms. Estimation of Distribution Algorithms (EDA), based on probabilistic modelling, have been proved to obtain good results in problems where genetic algorithms struggle. In this paper we propose to adapt three EDAs to tackle the multi-objective NRP in a fast and effective way. Results show that EDAs can be applicable to solve the NRP with rather good quality of solutions. Furthermore, we prove that their execution time can be significantly reduced using a per-iteration solution subset selection method while maintaining the overall quality of the solutions obtained, and they perform the best when limiting the search time as in an interactive tool that requires fast responsiveness. The experimental framework, code and datasets have been made public in a code repository.