bluuebunny/crossref_metadata_2025_split huggingface dataset:
Frequent down‐regulation of hABH2 in gastric cancer and its involvement in growth of cancer cells
Authors: Gao Wei , Li Leijia , Xu Ping , Fang Jingyuan , Xiao Shudong , Chen Shengliang 
Published: October 2010

AbstractBackground and Aim:  Methyl or 1, N6‐ethenoadenine base lesions are frequent and highly‐mutagenic or ‐carcinogenic events in mammalian DNA. Human AlkB homologue‐2 (hABH2), a homologue of the Escherichia coli AlkB protein, has been found to be the principal dioxygenase for the repair of these lesions. Mounting evidence indicates that impaired DNA repair contributes to gastric cancer induction and progression. Whether hABH2 is involved in this malignancy is unknown. The present study was aimed to investigate the expression profile of hABH2 in gastric cancer and the effect of hABH2 on cancer cell growth.Methods:  The expression of hABH2 in 35 pair‐matched gastric neoplastic and adjacent non‐neoplastic tissues, and in five gastric cancer cell lines, was examined by real‐time polymerase chain reaction (PCR), immunohistochemistry, or Western blot. The cell growth was determined using cell‐counting kit‐8 assay. The apoptosis or cell‐cycle analysis was determined using flow cytometry.Results:  The hABH2 expression was downregulated in 68% (24/35) of primary gastric cancers, as determined by real‐time PCR; the hABH2 expression was also substantially decreased in gastric cancer cell lines. Immunohistochemical or Western blot analysis further confirmed the downregulation of hABH2 expression in gastric cancers. The overexpression of hABH2 significantly inhibited the proliferation of gastric cancer cells, and induced G1 arrest of the cell cycle, while hABH2 knockdown promoted cell growth and cell‐cycle progression of gastric cancer cells.Conclusions:  These results suggest that hABH2 is downregulated in a subset of gastric cancers, and might be involved in the molecular mechanism of gastric cancer through inhibiting the proliferation of gastric cancer cells.
Ovarian cyst torsion coexisting with acute pyelonephritis in an eight‐year‐old premenarchal girl
Authors: Kim Rahyeon , Kim Youngjae , Roh Jaesook 
Published: October 2010

AbstractWe report the case of a premenarchal eight‐year‐old girl with an adnexal torsion accompanied by acute pyelonephritis with vague, non‐specific symptoms. In young girls, symptoms may be vague, with patients complaining of non‐specific gastro‐intestinal problems. Combination with other complications such as pyelonephritis makes the diagnosis of adnexal torsion even more difficult as in the present case. To preserve future reproductive function, early surgical intervention is required. Although the impact on menarchal development of oophorectomy or partial removal of ovarian tissue before menarche remains to be evaluated, timely recognition and treatment of adnexal torsion clearly increases the possibility of retaining the ovary. Therefore, to decrease the time between the onset of symptoms and the identification of patients at risk, sonography should be considered as a first imaging modality for evaluating children with any degree of abdominal pain accompanied by non‐specific symptoms.
A simplified table improves the recognition of paediatric hypertension
Authors: Mitchell Charlene K , Theriot Judith A , Sayat Jonathan G , Muchant Dianne G , Franco Sofia M 
Published: October 2010

Aim:  Unrecognised and untreated hypertension can lead to significant morbidity and mortality over time. In a 2003 chart review, we found that our providers only recognised 15% of hypertensive blood pressure (BP). Our objective was to determine whether a simplified BP table improves the recognition of elevated BP in children.Methods:  We developed a simplified BP table for children 3–18 years and posted it in provider work areas beginning August 2006. We reviewed a retrospective sample of well visits for children aged 3–18 years, with equal numbers by sex and year of age, presenting at a university‐based paediatric clinic between January and August 2007. Visit notes for all children with elevated BP values ≥90th percentile were reviewed to identify whether the provider recognised that the BP was elevated.Results:  In 493 well visits, 85 (17.2%) children had pre‐hypertensive (90th to <95th percentile) and 100 (20.3%) had hypertensive (≥95th percentile) BP values. Providers recognised elevations in 34 (40%) pre‐hypertensive and 77 (77%) hypertensive measurements. Recognition was significantly more common for those in the hypertensive than the pre‐hypertensive range (χ2 = 24.9, degrees of freedom = 1, P < 0.001). Compared with our 2003 data, recognition of hypertensive BP values was significantly greater (77% vs. 15%) (t = 14.479, degrees of freedom = 98, P < 0.001) after introduction of the simplified BP table.Conclusions:  Use of a simplified BP table can lead to significantly improved recognition of elevated BP in children.
Maternal psychosocial factors around delivery on development of 2‐year‐old children: A prospective cohort study
Authors: Chuang Chao‐Hua , Liao Hua‐Fang , Hsieh Wu‐Shiun , Jeng Suh‐Fang , Su Yi‐Ning , Chen Pau‐Chung 
Published: October 2010

Aim:  To explore whether maternal psychosocial factors around delivery are related to development of 2‐year‐old children.Methods:  Pregnant women going to the hospital for delivery were recruited, and their children were observed at 24 months. A total of 186 mother–child dyads completed the measurement. Self‐report data of maternal psychosocial factors around delivery were selected from the Taiwanese version of the short‐form 36. The Comprehensive Developmental Inventory for Infants and Toddlers was completed by interviewers and the main care givers for the child at 2 years old.Results:  Using the multiple linear regression analysis and adjusting for potential confounders, maternal vitality around delivery was found to have a significantly positive relationship with the whole Comprehensive Developmental Inventory for Infants and Toddlers (P = 0.005) and self‐help development (P = 0.001), but work stress had a significantly negative relationship with motor development (seldom, P = 0.050; always, P = 0.048).Conclusions:  Maternal vitality around delivery was beneficial to a child's self‐help development, while work stress seemed to be an adverse effect on child's motor development in later life. It is important to improve the psychosocial health of pregnant women.
Proteomic assessment of host‐associated microevolution in the fungus Thielaviopsis basicola
Authors: Coumans J. V. F. , Harvey J. , Backhouse D. , Poljak A. , Raftery M. J. , Nehl D. , Katz M. E. , Pereg L. 
Published: October 2010

Summary Thielaviopsis basicola, a soil‐borne pathogen with a broad host range and a cosmopolitan distribution, is emerging as a major risk to sustainable cotton production in Australia. Previous studies suggested that host specialization has occurred making T. basicola an ideal model for a comparative proteomic analysis of strains isolated from different hosts. Elucidation of the genomic diversity and investigation of the functional differences in the Australian population could provide valuable information towards disease control. In this study, isolates of T. basicola were investigated for genomic (internal transcribed spacers region), proteomic and cotton virulence level variations. Internal transcribed spacers sequence analysis revealed that isolates are grouped based on host of origin irrespective of geographical origin. At the proteome level a degree of diversity was apparent and hierarchical clustering analysis of the data also demonstrated a close correlation between the proteome and the host of origin. LC‐MS/MS analysis and identification using cross‐species similarity searching and de novo sequencing of host‐specific differentially expressed proteins and the virulence‐correlated proteome allowed successful identification of 43 spots. The majority were found to be involved in metabolism. Spots that were correlated with host and virulence differences included a hypothetical protein with a Rossman‐fold NAD(P)(+)‐binding protein domain, glyceraldehyde‐3‐phosphate dehydrogenase, arginase and tetrahydroxynaphthalene reductase.
Haemorrhoids and quality of life
Authors: Riss S. , Weiser F. A. , Riss T. , Schwameis K. , Mittlböck M. , Stift A. 
Published: October 2010

AbstractAim  There are few studies into the quality of life of patients with haemorrhoids. The aim of this study was to assess the quality of life of patients with haemorrhoids in an adult general population.Method  Participants, who attended the Austrian nationwide healthcare programme for colorectal cancer screening at four medical institutions, were enrolled prospectively between 2008 and 2009. A colonoscopy was performed in all patients. Haemorrhoids were classified according to an international grading system and defined as symptomatic in cases with bleeding, itching, soiling or pain. Quality of life was measured by the Short Form‐12 Health Survey.Results  Of 976 participants, 380 patients (39%) had haemorrhoids. The median physical health score was 52.6 (range 20.6–61.3) in the symptomatic and 53.2 (range 16.2–61.3) in the asymptomatic group (P = 0.7993). The median mental health score showed also no significant difference between both groups [symptomatic group, 52.8 (range 12.4–62.6); asymptomatic group, 54.8 (range 18.7–67.2); P = 0.0738].Conclusion  Haemorrhoids, irrespective of their degree, do not influence quality of life measured by the Short Form‐12 Health Survey.
Do attitudes about unhealthy alcohol and other drug (AOD) use impact primary care professionals' readiness to implement AOD‐related preventive care?
Authors: AMARAL‐SABADINI MICHAELA B. , SAITZ RICHARD , SOUZA‐FORMIGONI MARIA LUCIA O. 
Published: October 2010

Abstract
Introduction and Aims. To explore the association between primary care professionals' (PCPs) attitudes towards unhealthy alcohol and other drug (AOD) use (from risky use through dependence) and readiness to implement AOD‐related preventive care. Design and Methods. Primary care professionals from five health centres in Sao Paulo were invited to complete a questionnaire about preventive care and attitudes about people with unhealthy AOD use. Logistic regression models tested the association between professional satisfaction and readiness. Multiple Correspondence Analysis assessed associations between stigmatising attitudes and readiness. Results. Of 160 PCPs surveyed, 96 (60%) completed the questionnaire. Only 25% reported implementing unhealthy AOD use clinical prevention practices; and 53% did not feel ready to implement such practices. Greater satisfaction when working with people with AOD problems was significantly associated with readiness to implement AOD‐related preventive care. In Multiple Correspondence Analysis two groups emerged: (i) PCPs ready to work with people with unhealthy AOD use, who attributed to such patients lower levels of dangerousness, blame for their condition and need for segregation from the community (suggesting less stigmatising attitudes); and (ii) PCPs not ready to work with people with unhealthy AOD use, who attributed to them higher levels of dangerousness, blame, perceived level of patient control over their condition and segregation (suggesting more stigmatising attitudes). Discussion and Conclusions. More stigmatising attitudes towards people with unhealthy AOD use are associated with less readiness to implement unhealthy AOD‐related preventive care. Understanding these issues is likely essential to facilitating implementation of preventive care, such as screening and brief intervention, for unhealthy AOD use. [Amaral‐Sabadini MB, Saitz R, Souza‐Formigoni MLO. Do attitudes about unhealthy alcohol and other drug (AOD) use impact primary care professionals' readiness to implement AOD‐related preventive care? Drug Alcohol Rev 2010;29;655–661]
Alcohol screening and brief intervention in a policing context: A mixed methods feasibility study
Authors: BROWN NICOLA , NEWBURY‐BIRCH DOROTHY , MCGOVERN RUTH , PHINN ELIZABETH , KANER EILEEN 
Published: October 2010

Abstract
Introduction and Aims. There is a strong association between alcohol and offending behaviour and 25% of police time involves alcohol‐related incidents. This pilot study aimed to investigate the feasibility of delivering alcohol screening and brief intervention (ASBI) to individuals arrested for offences linked to drinking behaviour. Design and Methods. Participants were detainees arrested for public order or assault offences in one North East police station in England. Following a 2 h training session, 10 Detention Officers (DOs) conducted ASBI over 3 months during routine police work. In‐depth interviews with the DOs provided further details about the acceptability of ASBI procedures. Results. Of 704 target arrestees, 229 (33%) agreed to participate in the study. Most were male (81%), white British (95%) and under the age of 30 (62%). Fifty‐nine per cent screened positively for an alcohol use disorder (50% were hazardous, 15% harmful and 35% dependent drinkers), although 23% detainees either refused or were unable to complete the screening tool. Of the 134 participants that screened positively, 98% were willing to receive brief intervention. DOs reported mixed views about ASBI; while half were positive about the process the remaining DOs expressed reservations about the appropriateness of the policing context for ASBI. Discussion and Conclusions. Despite limited training, DOs were able to deliver ASBI during routine police work. These findings provide a promising platform for future evaluative research on brief intervention outcomes in this setting. However, the issue of coercion needs to be explored more fully with both detainees and DOs.[Brown N, Newbury‐Birch D, McGovern R, Phinn E, Kaner E. Alcohol screening and brief intervention in a policing context: A mixed methods feasibility study. Drug Alcohol Rev 2010;29;647–654]
Dose–response expectancies for alcohol: Validation and implications for brief interventions
Authors: ADEY GWEN E. , MOORE SIMON C. , CHESTNUTT IVOR G. 
Published: October 2010

Abstract
Introduction and Aims. Brief interventions for alcohol problems are informed by elements of behavioural motivation theories and behaviour change models. However, motivations across drinking occasions have yet to be explored. This paper addresses this need and presents initial validity statistics for a new construct, Dose Response Expectancies for Alcohol Metrics (DREAM) that can be used to investigate expectancies across the drinking session and thus inform novel interventions. Design and Methods. Twenty‐seven participants completed a test–retest reliability assessment. Hypothesised systematic relationships between the hypothetical number of drinks consumed across a drinking session and anticipated affective responses were assessed. Results. The DREAM questionnaire yielded good test–retest statistics for anticipated happiness and nausea in the hours following drinking. Consistent with hypotheses, DREAM yielded a systematic relationship between anticipated alcohol dose and affective response. Discussion and Conclusions. DREAM offers a novel means to investigate alcohol dose–response expectancies across drinking sessions and to therefore provide a theoretical platform that can be used to inform effective brief interventions for young people.[Adey GE, Moore SC, Chestnutt IG. Dose–response expectancies for alcohol: Validation and implications for brief interventions. Drug Alcohol Rev 2010;29;662–668]
What process research tells us about brief intervention efficacy
Authors: DAEPPEN JEAN‐BERNARD , BERTHOLET NICOLAS , GAUME JACQUES 
Published: October 2010

AbstractIssue. This article explores mechanisms of the efficacy of brief intervention (BI). Approach. We conducted a BI trial at the emergency department of the Lausanne University Hospital, of whom 987 at‐risk drinkers were randomised into BI and control groups. The overall results demonstrated a general decrease in alcohol use with no differences across groups. The intention to change was explored among 367 patients who completed BI. Analyses of 97 consecutive tape‐recorded sessions explored patient and counsellor talks during BI, and their relationship to alcohol use outcome. Key Findings. Evaluation of the articulation between counsellor behaviours and patient language revealed a robust relationship between counsellor motivational interviewing (MI) skills and patient change talk during the intervention. Further exploration suggested that communication characteristics of patients during BI predicted changes in alcohol consumption 12 months later. Moreover, despite systematic training, important differences in counsellor performance were highlighted. Counsellors who had superior MI skills achieved better outcomes overall, and maintained efficacy across all levels of patient ability to change, whereas counsellors with inferior MI skills were effective mostly with patients who had higher levels of ability to change. Finally, the descriptions of change talk trajectories within BI and their association with drinking 12 months later showed that final states differed from initial states, suggesting an impact resulting from the progression of change talk during the course of the intervention. Implication. These findings suggest that BI should focus on the general MI attitude of counsellors who are capable of eliciting beneficial change talk from patients. [Daeppen J‐B, Bertholet N, Gaume J. What process research tells us about brief intervention efficacy. Drug Alcohol Rev 2010;29;612–616]
Conducting economic evaluations of screening and brief intervention for hazardous drinking: Methods and evidence to date for informing policy
Authors: COWELL ALEXANDER J. , BRAY JEREMY W. , MILLS MICHAEL J. , HINDE JESSE M. 
Published: October 2010

AbstractIssues.Many policy review articles have concluded that alcohol screening and brief intervention (SBI) is both cost‐effective and cost‐beneficial. Yet a recent cost‐effectiveness review for the United Kingdom's National Institute for Health and Clinical Excellence suggests that these conclusions may be premature.Approach.This article offers a brief synopsis of the various types of economic analyses that may be applied to SBI, including cost analysis, cost‐effectiveness analysis, cost‐utility analysis, cost‐benefit analysis and other types of economic evaluation. A brief overview of methodological issues is provided, and examples from the SBI evaluation literature are provided.Key Findings, Implications and Conclusions.The current evidence base is insufficient to draw firm conclusions about the cost, cost‐effectiveness or cost‐benefit of SBI and about the impact of SBI on health‐care utilisation.[Cowell AJ, Bray JW, Mills MJ, Hinde JM. Conducting economic evaluations of screening and brief intervention for hazardous drinking: Methods and evidence to date for informing policy.Drug Alcohol Rev2010;29;623–630]
Telephonic screening and brief intervention for alcohol misuse among workers contacting the employee assistance program: A feasibility study
Authors: MCPHERSON TRACY L. , GOPLERUD ERIC , DERR DENNIS , MICKENBERG JUDY , COURTEMANCHE SHERRY 
Published: October 2010

Abstract
Introduction and Aims. Substantial empirical support exists for alcohol screening, brief intervention, and referral to treatment (SBIRT) in medical, but not non‐medical settings such as the workplace. Workplace settings remain underutilised for delivering evidenced‐based health services. This research aims to translate medical research into behavioural health‐care practice in a telephonic call centre acting as a point of entry into an Employee Assistance Program (EAP). The goal of the study is to examine the feasibility of implementing routine telephonic alcohol SBIRT in an EAP call centre and assess whether routine SBIRT results in increased identification of workers who misuse alcohol. Design and Methods. The design was pretest–posttest, one‐group, pre‐experimental. An alcohol SBIRT program developed based on World Health Organization recommendations was implemented in one EAP call centre serving one large employer. Workers were offered screening using the Alcohol Use Disorder Identification Test (AUDIT) during intake, brief counselling using motivational interviewing, referral to counselling, and follow‐up. Results. At 5 months, 93% of workers contacting the EAP completed the AUDIT‐C: 40% prescreened positive and 52% went on to screen at moderate or high risk for an alcohol problem. Overall identification rate (18%) approached general US population estimates. Most agreed to follow‐up and three‐quarters set an appointment for face‐to‐face counselling. Discussion and Conclusions. Integration of routine alcohol SBIRT into EAP practice is feasible in telephonic delivery systems and increases identification and opportunity for brief motivational counselling. When SBIRT is seamlessly integrated workers are willing to answer questions about alcohol and participate in follow‐up.[McPherson TL, Goplerud E, Derr D, Mickenberg J, Courtemanche S. Telephonic screening and brief intervention for alcohol misuse among workers contacting the employee assistance program: A feasibility study. Drug Alcohol Rev 2010;29;641–646]
Is bigger better? Macrosomia and psychopathology later in life
Authors: Van Lieshout R. J. , Boyle M. H. 
Published: October 2010

SummaryEvidence suggests that a curvilinear relationship may exist between birth weight and later psychopathology. Increases in the prevalence of macrosomia and of two of its risk factors (maternal pre‐pregnancy obesity and diabetes mellitus) and their amenability to intervention argue for a critical review of the association between macrosomia and mental illness. Of the nine studies in adults and six studies in youth that have examined associations between macrosomia and psychiatric disorders, seven have provided evidence suggestive of a link. Significant methodological variability and an inability to adjust for important confounders limit the findings of these studies. As a result, it remains unclear if individuals born macrosomic are at increased risk for psychopathology later in life. Future work should attempt to examine a broader range of psychiatric outcomes, use validated measures, include data on putative confounders and utilize genetically sensitive designs to assess associations between macrosomia, its precursors and later psychological and emotional functioning.
Geofluids and natural gas in Romania, and the 10th International Conference on Gas Geochemistry
Authors: ETIOPE G. , BACIU C. 
Published: October 2010

AbstractThis thematic issue of Geofluids includes 11 papers representing the three main topics discussed in the 10th edition of the International Conference on Gas Geochemistry (ICGG‐10): (i) gas in petroleum systems and seepage, (ii) gas in geothermal systems and volcanoes and (iii) gas, seismicity and geohazards. ICGG‐10 was held in 2009 in Romania, a country extraordinarily rich in surface gas manifestations, that offers innumerable opportunities for innovative studies on gas geochemistry. We briefly describe the present knowledge on gases occurring both in petroliferous sedimentary basins and geothermal areas of Romania. The 11 contributions of this special issue, which include data from eight countries, are then summarised. Based on these papers and other works presented at the ICGG‐10, we find that significant advances in analytical capabilities, data treating and interpretation have led to innovative insights into the origin, distribution and environmental impact of gases migrating to the Earth’s surface. It is increasingly clear, in particular, that gas geochemistry can be more effective for petroleum exploration, volcano‐tectonic, geodynamic and environmental studies, if multiparametric studies are performed and the data are interpreted in the geological context.