bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Chemoselectivity: The Mother of Invention in Total Synthesis
Authors: Shenvi Ryan A. , O'Malley Daniel P. , Baran Phil S. 
Published: July 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Phosphonium‐Based Ionic Liquids: An Overview
Authors: Fraser Kevin J. , MacFarlane Douglas R. 
Published: July 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Catalytic Asymmetric Intramolecular Stetter Reaction
Authors: Read de Alaniz Javier , Rovis Tomislav 
Published: July 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Intramolecular Anodic Olefin Coupling Reactions: Using Radical Cation Intermediates to Trigger New Umpolung Reactions
Authors: Moeller Kevin D. 
Published: July 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Automated Solution‐Phase Oligosaccharide Synthesis and Carbohydrate Microarrays: Development of Fluorous‐Based Tools for Glycomics
Authors: Pohl Nicola L. 
Published: July 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Chemoenzymatic Synthesis of Sialosides and Their Applications
Authors: Yu Hai , Chokhawala Harshal A. , Huang Shengshu , Chen Xi 
Published: July 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Asymmetric N‐Acyliminium Cyclization as an Approach to Heterocyclic Natural Product Synthesis
Authors: Gaskell Sean N. , Duffy Liam J. , Allin Steven M. 
Published: July 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Silylformylation of Functional 1‐Alkynes in the Synthesis of Fine Chemicals: Nanostructured Rhodium‐Supported Catalysts for the Synthesis of β‐Lactams and β‐Lactones Rings
Authors: Aronica L. A. , Caporusso A. M. , Salvadori P. 
Published: July 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Ionic Liquids: Solvation Ability and Polarity
Authors: Chiappe Cinzia , Malvaldi Marco , Pomelli Christian Silvio 
Published: July 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: In situ Alkylcarbonic Acid Catalysts Formed in CO2‐Expanded Alcohols
Authors: Hallett Jason P. , Eckert Charles A. , Liotta Charles L. 
Published: July 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Chemoenzymatic Synthesis of Small Molecule Human Therapeutics
Authors: Ran Ningqing , Rui Eugene , Liu Jinhua , Tao Junhua 
Published: July 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Epibatidine: From Frog Alkaloid to Analgesic Clinical Candidates. A Testimonial to “True Grit”!
Authors: Garraffo H. Martin , Spande Thomas F. , Williams Michael 
Published: July 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Molecular Designs and Syntheses of Organic Dyes for Dye‐Sensitized Solar Cells
Authors: Ooyama Yousuke , Harima Yutaka 
Published: July 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Recent Developments in Solid Acid, Base, and Enzyme Catalysts (Heterogeneous) for Biodiesel Production via Transesterification
Authors: Jothiramalingam Rajabathar , Wang Ming Kuang 
Published: July 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Supramolecular Association of Polyelectrolytes to Complementary Charged Surfactants and Protein Assemblies
Authors: Perico Angelo , Ciferri Alberto 
Published: July 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Internal and External Factors Influencing the Diels—Alder Reaction
Authors: Kiselev Vladimir D. , Konovalov Alexander I. 
Published: July 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A computationally inspired investigation of the solid forms of (R)‐1‐phenylethylammonium‐(S)‐2‐phenylbutyrate
Authors: Antoniadis Constantinos D. , D'Oria Emiliana , Karamertzanis Panagiotis G. , Tocher Derek A. , Florence Alastair J. , Price Sarah L. , Jones Alan G. 
Published: July 2009

AbstractFollowing the computation of a lattice energy landscape which predicted that there should be more stable, denser forms of (R)‐1‐phenylethylammonium‐(S)‐2‐phenylbutyrate, crystallizations from a range of solvents were performed to search for other polymorphs and investigate the possibility that the known P41 structure could be a hydrate. Extensive crystallization experiments from a wide range of solvents gave fine needles or microcrystalline samples. A redetermination of the P41 structure by powder X‐ray diffraction located all protons, and in conjunction with other experimental and computational evidence showed that the structure was anhydrous. Evidence for two additional forms was found as mixtures with form I. These include an orthorhombic form, possibly a Z′ = 3 polymorph, and another as yet unidentified form obtained as a minor component from dichloromethane solution. However, both these forms appear to be metastable with respect to form I (P41), which is therefore probably the most thermodynamically stable form that can be crystallized from solution under ambient conditions. This determination of the solid state behavior of the less readily crystallized member of the diastereomeric salt system (R)‐1‐phenylethylammonium‐(R/S)‐2‐phenylbutyrate provides a challenge to the theoretical modeling to explain its ideal resolution behavior. Chirality 2010. © 2009 Wiley‐Liss, Inc.
Stereoselective metabolism of propranolol glucuronidation by human UDP‐glucuronosyltransferases 2B7 and 1A9
Authors: Yu Lushan , Qian Minrong , Liu Yao , Yao Tongwei , Zeng Su 
Published: July 2009

AbstractStereoselective metabolism of propranolol side‐chain glucuronidation was studied for two recombinant human uridine diphosphate glucuronosyltransferases (UGTs), UGT1A9 and UGT2B7. TheS‐ andR‐propranolol side‐chain glucuronides produced in the incubation mixtures were assayed simultaneously by RP‐HPLC with fluorescent detector. The excitation and emission wavelengths were set at 310 nm and 339 nm, respectively. UGT1A9 prefers catalyzingS‐enantiomer toR‐enantiomer and the intrinsic clearance (CLint) ratios ofS‐enantiomer toR‐enantiomer are 3.8 times and 6.5times for racemic propranolol and individual enantiomers, respectively. UGT2B7, however, catalyzes slightly lessS‐enantiomer thanR‐enantiomer and the CLintratio ofS‐enantiomer toR‐enantiomer is 0.8 times. The high concentration of racemic propranolol (>0.57 mmol/l) and individual enantiomers (>0.69 mmol/l) exhibited substrate inhibition of glucuronidation for UGT2B7, but only theS‐enantiomer (>0.44 mmol/l) in racemic propranolol exhibited substrate inhibition for UGT1A9. The substrate inhibition constants (Ksi) were all similar (P> 0.05). Drug–drug interactions were also found betweenS‐ andR‐enantiomer glucuronidation metabolisms by UGT1A9 and UGT2B7. Chirality 2010. © 2009 Wiley‐Liss, Inc.
Does Reperfusion in the Treatment of Acute Myocardial Infarction Improve the Prognosis of Acute Myocardial Infarction in Diabetic Patients?
Authors: Janion Marianna , Polewczyk Anna , Ga̧sior Mariusz , Gierlotka Marek , Poloński Lech 
Published: July 2009

AbstractBackgroundDiabetic patients have a 6‐fold increased mortality in acute coronary syndromes.HypothesisDifferent therapeutic strategies in diabetics with acute coronary syndromes have an impact on in‐hospital and long‐term prognosis.MethodsA total of 889 consecutive patients with ST‐segment elevation myocardial infarction were included and followed‐up for at least 6 months. The study population consisted of 168 (18.9%) diabetic patients and 721 nondiabetics.ResultsInvasive therapy and fibrinolysis were less frequently used in diabetic patients (38.7% versus 50.2%; p = 0.0071 and 8.3% versus 15%; p = 0.024, respectively). In‐hospital mortality in diabetic individuals was almost twice as high as in nondiabetic subjects (20.2% versus 11.1%; p < 0.0014). In‐hospital mortality was slightly higher in diabetic patients undergoing primary percutaneous transluminal coronary angioplasty (PTCA; 8.3% versus 4.8%; p = 0.35), but lower in those treated with fibrinolysis (7.7% versus 16%; p = 0.7) compared with the rest of the patients. At 6‐mo follow‐up mortality was significantly higher in diabetic subjects as compared with nondiabetic subjects (28.0% versus 15.1%; p < 0.0001). The highest number of deaths was found in individuals receiving conservative treatment with diabetic subjects significantly outnumbering nondiabetic individuals (40.1% versus 27.9%; p = 0.028 at 6 mo). Both in‐hospital and 6‐mo mortality were similar in diabetics and nondiabetics receiving reperfusion therapy (7.1% versus 8.2%; p < 0.68 and 9.3% versus 15.3%; p < 0.098, respectively).ConclusionReperfusion therapy, both fibrinolysis and the invasive approach, reduced in‐hospital mortality from that observed in nondiabetic individuals. Copyright © 2009 Wiley Periodicals, Inc.
Preinfarction Angina Prior to First Myocardial Infarction Does not Influence Long‐Term Prognosis: A Retrospective Study with Subgroup Analysis in Elderly and Diabetic Patients
Authors: Jiménez‐Navarro Manuel F. , Muñoz‐García Antonio , Ramirez‐Marrero Miguel A. , Dominguez‐Franco Antonio , García Alcántara Angel , José Gómez‐Doblas Juan , Alonso‐Briales Juan , María Hernández‐García José , Salva Dolores , Rodriguez‐Losada N. , de Teresa Eduardo 
Published: July 2009

AbstractBackground and hypothesisAlthough prodromal angina occurring shortly before an acute myocardial infarction (MI) has protective effects against in‐hospital complications, this effect has not been well documented after initial hospitalization, especially in older or diabetic patients. We examined whether angina 1 week before a first MI provides protection in these patients.MethodsA total of 290 consecutive patients, 143 elderly (>64 years of age) and 147 adults (<65 years of age), 68 of whom were diabetic (23.4%) and 222 nondiabetic (76.6%), were examined to assess the effect of preceding angina on long‐term prognosis (56 months) after initial hospitalization for a first MI.ResultsNo significant differences were found in long‐term complications after initial hospitalization in these adult and elderly patients according to whether or not they had prodromal angina (44.4% with angina vs 45.4% without in adults; 45.5% vs 58% in elderly, P < 0.2). Nor were differences found according to their diabetic status (61.5% with angina vs 72.7% without in diabetics; 37.3% vs 38.3% in nondiabetics; P = 0.4).ConclusionThe occurrence of angina 1 week before a first MI does not confer long‐term protection against cardiovascular complications after initial hospitalization in adult or elderly patients, whether or not they have diabetes. Copyright © 2009 Wiley Periodicals, Inc.
Clinical Outcomes for Single Stent and Multiple Stents in Contemporary Practice
Authors: Shu Bin Qiao , Wen Liu Sheng , Bo Xu , Jue Chen , Hai Bo Liu , Jin Yang Yue , Ji Lin Chen , Lin Gao Run 
Published: July 2009

AbstractBackgroundStents had been demonstrated to be safe and effective in the treatment of severe coronary artery disease (CAD); however, the current knowledge on percutaneous coronary intervention (PCI) in treating patients requiring 2 or more stents placements is still limited.HypothesisPatients who required 2 or more stents might have worse clinical outcomes.MethodsA total of 2371 patients who underwent stenting were divided into a single stenting group (n = 1233) and a multiple stenting group (n = 1138). We assessed the cumulative incidence of major adverse cardiac events (death, acute myocardial infarction, and target‐vessel revascularization) and stent thrombosis during 1‐year follow‐up.ResultsThe 1‐year unadjusted cumulative incidence of major adverse cardiac events was 7.7% in the multiple stenting group and 5.4% in the single stenting group (P = 0.02 by log‐rank test). After adjustment, there was a trend toward a lower rate of 1‐year major adverse cardiac events in the single stenting group than in the multiple stenting group (P = 0.09). A nonsignificant trend was also detected in favor of the single stenting group, as compared with the multiple stenting group, at the rate of acute myocardial infarction (1.3% vs 1.7%, P = 0.89) and at the rate of target‐vessel revascularization (4.5% vs 5.4%, P = 0.08).ConclusionsAlthough the use of a single stent in coronary artery disease has less incidence of adverse cardiac events at 1 year as compared with the use of multiple stents, the difference was not statistically significant. Copyright © 2009 Wiley Periodicals, Inc.
Hypercholesterolemia Paradox in Relation to Mortality in Acute Coronary Syndrome
Authors: Wang Tracy Y. , Newby L. Kristin , Chen Anita Y. , Mulgund Jyotsna , Roe Matthew T. , Sonel Ali F. , Bhatt Deepak L. , DeLong Elizabeth R. , Ohman E. Magnus , Gibler W. Brian , Peterson Eric D. 
Published: July 2009

AbstractBackgroundHypercholesterolemia is a risk factor for coronary artery disease, yet is associated with lower risk of adverse outcomes in patients with acute coronary syndromes (ACS).HypothesisWe explored this paradox in 84 429 patients with non‐ST‐segment elevation ACS in the Can Rapid Risk Stratification of Unstable Angina Patients Suppress Adverse Outcomes with Early Implementation of the American College of Cardiology/American Heart Association Guidelines registry.MethodsWe examined the association between a history of hypercholesterolemia and in‐hospital mortality after adjusting for clinical covariates. After excluding patients with previously diagnosed hypercholesterolemia, we repeated the analysis, examining the association between newly diagnosed hypercholesterolemia (in‐hospital low‐density lipoprotein cholesterol [LDL‐C] ≥ 100 mg/dL) and mortality.ResultsA history of hypercholesterolemia was associated with lower in‐hospital mortality (unadjusted odds ratio [OR]: 0.58; 95% confidence interval [CI]: 0.55, 0.62). This protective association persisted after adjusting for baseline characteristics (OR: 0.71; 95% CI: 0.66, 0.76) and prior statin use (OR: 0.74; 95% CI: 0.68, 0.80). Among 22 711 patients with no history of hypercholesterolemia, 12 809 had a new in‐hospital diagnosis of hypercholesterolemia. Unadjusted mortality in these patients was lower than among those with normal LDL levels (OR: 0.58; 95% CI: 0.50, 0.67); however, this difference was not significant after multivariable adjustment (OR: 0.86; 95% CI: 0.73, 1.01).ConclusionsThe association of hypercholesterolemia with better outcomes highlights a major challenge in observational analyses. Our results suggest this paradox may result from confounding due to other clinical characteristics, impact of statin treatment, and perhaps most importantly, the fact that previously diagnosed hypercholesterolemia is a marker for patients with more prior medical contact. Copyright © 2009 Wiley Periodicals, Inc.
18F‐fluorodeoxyglucose positron emission tomography/computed tomography (FDG‐PET/CT) imaging in the staging and prognosis of inflammatory breast cancer
Authors: Alberini Jean‐Louis , Lerebours Florence , Wartski Myriam , Fourme Emmanuelle , Le Stanc Elise , Gontier E. , Madar O. , Cherel P. , Pecking A. P. 
Published: July 2009

AbstractBACKGROUND:To prospectively assess fluorodeoxyglucose positron emission tomography/computed tomography (FDG‐PET/CT) staging and prognosis value in patients with suspected inflammatory breast cancer (IBC).METHODS:Sixty‐two women (mean age 50.7 ± 11.4 years) presenting with unilateral inflammatory breast tumors (59 invasive carcinomas; 3 mastitis) underwent a PET/CT scan before biopsy.RESULTS:PET/CT scan was positive for the primary malignant tumor in 100% and false positive in 2 of 3 benign mastitis. In 59 IBC patients, FDG nodal foci were detected in axillary (90%; n = 53) and extra‐axillary areas (56%; n = 33) ipsilateral to the cancer. Compared with clinical examination, the axillary lymph node status by PET/CT was upstaged and downstaged in 35 and 5 patients, respectively. In 7 of 9 N0 patients, the axillary lymph node positivity on PET/CT was correct, as revealed by pathological postsurgery assessment (not available in the 2 remaining patients). The nodal foci were compared with preoperative fine needle aspiration and/or pathological postchemotherapy findings available in 44 patients and corresponded to 38 true positive, 4 false‐negative, and 2 false‐positive cases. In 18 of 59 IBC patients (31%), distant lesions were found. On the basis of a univariate analysis of the first enrolled patients (n = 42), among 28 patients who showed intense tumoral uptake (standard uptake valuemax>5), the 11 patients with distant lesions had a worse prognosis than the 17 patients without distant lesions (P = .04).CONCLUSIONS:FDG‐PET/CT imaging provides additional invaluable information regarding nodal status or distant metastases in IBC patients and should be considered in the initial staging. It seems also that some prognostic information can be derived from FDG uptake characteristics. Cancer 2009. © 2009 American Cancer Society.
Age‐specific physical activity and prostate cancer risk among white men and black men
Authors: Moore Steven C. , Peters Tricia M. , Ahn Jiyoung , Park Yikyung , Schatzkin Arthur , Albanes Demetrius , Hollenbeck Albert , Leitzmann Michael F. 
Published: July 2009

AbstractBACKGROUND:The relation of physical activity across the lifespan to risk of prostate cancer has not been thoroughly investigated, particularly among black men. The authors investigated physical activity, including activity during different age periods and of various intensities, in relation to prostate cancer incidence among white men and black men.METHODS:In total, 160,006 white men and 3671 black men ages 51 years to 72 years who were enrolled in the National Institutes of Health‐AARP Diet and Health Study reported their time spent per week engaging in physical activity during ages 15 to 18 years, 19 years to 29 years, 35 years to 39 years, and during the past 10 years. Cox regression models were used to examine physical activity, categorized by intensity (moderate or vigorous, light, and total), in relation to prostate cancer risk.RESULTS:During 7 years of follow‐up, 9624 white men and 371 black men developed prostate cancer. Among white men, physical activity had no association with prostate cancer regardless of age period or activity intensity. Among black men, engaging in ≥4 hours of moderate/vigorous intensity physical activity versus infrequent activity during ages 19 years to 29 years was related to a 35% lower risk of prostate cancer (relative risk, 0.65; 95% confidence interval [95% CI], 0.43‐0.99 [Ptrend = .01]). Frequent moderate/vigorous physical activity at ages 35 years to 39 years also potentially was related to reduced prostate cancer risk (relative risk, 0.59; 95% CI, 0.36‐0.96 [Ptrend = .15]).CONCLUSIONS:Regular physical activity may reduce prostate cancer risk among black men, and activity during young adulthood may yield the greatest benefit. This novel finding needs confirmation in additional studies. Cancer 2009. Published 2009 by the American Cancer Society.