bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations between Hours Worked, Symptoms and Health Resource Utilization among Full‐time Male Japanese Workers
Authors: Sato Keiko , Yamazaki Shin , Hayashino Yasuaki , Takegami Misa , Tokuda Yasuharu , Takahashi Osamu , Shimbo Takuro , Hinohara Shigeaki , Fukui Tsuguya , Fukuhara Shunichi 
Published: April 2011

Associations between Hours Worked, Symptoms and Health Resource Utilization among Full‐time Male Japanese Workers: Keiko Sato, et al. Department of Epidemiology and Health Care Research, Graduate School of Medicine and Public Health, Kyoto University—ObjectivesTo investigate the association between hours worked, symptoms experienced, and health resource utilization.MethodsData were collected from a nationally representative sample of households in Japan. We studied full‐time male workers aged 18–65 yr who worked 100 h or more per month. First, we examined the association between hours worked and symptoms experienced. Second, we examined the association between hours worked and the type of health resource utilized, such as physician visits, over‐the‐counter (OTC) medication use, dietary supplement use, and complementary and alternative medicine (CAM) provider visits. We used a multivariable negative binominal model in each analysis.ResultsOf the 762 male workers, 598 reported experiencing symptoms at least once a month. We categorized participants based on the number of hours worked per month (h/mo): 100–200 h/mo, 201–250 h/mo, and over 250 h/mo. Compared with those working 201–250 h/ mo, those working 100–200 h/mo had more frequent physician visits (rate ratio:1.67, 95% CI: 1.17 to 2.38) and those working over 250 h/mo had significantly lower rates of CAM provider visits and tended to use dietary supplements for symptoms. Participants who worked 201–250 h/mo used OTC medication most frequently. No significant association was observed between the number of hours worked and number of symptoms experienced.ConclusionsThe more hours worked by full‐time male workers, the more likely they were to use health resources that had a lower time requirement. Greater attention should be paid to patterns of health resource utilization among workers and their consequent Influence on long‐term health status.
ALD of Al2O3 for Carbon Nanotube vertical interconnect and its impact on the electrical properties
Authors: Chiodarelli Nicolo’ , Delabie Annelies , Masahito Sugiura , Kashiwagi Yusaku , Richard Olivier , Bender Hugo , Cott D. J. , Heyns Marc , De Gendt Stefan , Groeseneken Guido , Vereecken Philippe M. 
Published: April 2011

ABSTRACTBecause of their superior electronic properties and bottom-up growth mode, Carbon Nanotubes (CNT) may offer a valid alternative for high aspect ratio vertical interconnects in future generations of microchips. For being successful, though, CNT based interconnects must reach sufficiently low values of resistance to become competitive with current W or Cu based technologies. This essentially means that CMOS compatible processes are needed to produce dense CNT shells of extremely high quality with almost ideal contacts. Moreover, their electrical properties must be preserved at every process step in the integration of CNT into vertical interconnect structures. In this work this latter aspect is analyzed by studying the changes in the electrical characteristics when encapsulating CNT into different oxides. Oxide encapsulation is often exploited to hold the CNT in place and to avoid snapping during a polishing step. On the other hand, oxide encapsulation can influence the properties of the grown CNT which are directly exposed to possibly harmful oxidative conditions. Two different deposition techniques and oxides were evaluated: Chemical Vapor Deposition (CVD) of SiO2 (reference) and Atomic Layer Deposition (ALD) of Al2O3 in less aggressive oxidizing conditions. The two processes were transferred to CNT interconnect test structures on 200mm wafers and electrically benchmarked. The CNT resistance was measured in function of the CNT length which allows the extraction and individual distinction of the resistive contributions of the CNT and the contacts. It is shown that the encapsulating SiO2 deposited by CVD degrades the resistance of CNT by altering their quality. Directions for future improvements have been identified and discussed.
Sunitinib in Metastatic Renal Cell Carcinoma: Recommendations for Management of Noncardiovascular Toxicities
Authors: Kollmannsberger Christian , Bjarnason Georg , Burnett Patrick , Creel Patricia , Davis Mellar , Dawson Nancy , Feldman Darren , George Suzanne , Hershman Jerome , Lechner Thomas , Potter Amy , Raymond Eric , Treister Nathaniel , Wood Laura , Wu Shenhong , Bukowski Ronald 
Published: April 2011

Abstract
The multitargeted tyrosine-kinase inhibitor sunitinib has emerged as one of the standards of care for good- and intermediate-risk metastatic renal cell carcinoma. Although generally associated with acceptable toxicity, sunitinib exhibits a novel and distinct toxicity profile that requires monitoring and management. Fatigue, diarrhea, anorexia, oral changes, hand-foot syndrome and other skin toxicity, thyroid dysfunction, myelotoxicity, and hypertension seem to be the most common and clinically relevant toxicities of sunitinib. Drug dosing and treatment duration are correlated with response to treatment and survival. Treatment recommendations for hypertension have been published but, currently, no standard guidelines exist for the management of noncardiovascular side effects. To discuss the optimal management of noncardiovascular side effects, an international, interdisciplinary panel of experts gathered in November 2009. Existing literature on incidence, severity, and underlying mechanisms of side effects as well as on potential treatment options were carefully reviewed and discussed. On the basis of these proceedings and the thorough review of the existing literature, recommendations were made for the monitoring, prevention, and treatment of the most common noncardiovascular side effects and are summarized in this review. The proactive assessment and consistent and timely management of sunitinib-related side effects are critical to ensure optimal treatment benefit by allowing appropriate drug dosing and prolonged treatment periods.
A sandwich anion receptor by a BODIPY dye bearing two calix[4]pyrrole units
Authors: Lv Yongjun , Xu Jian , Guo Yong , Shao Shijun 
Published: April 2011

AbstractA novel dicalix[4]pyrrolyl-substituted 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) dye I with an absorption peak at approximately 670 nm and an emission peak at about 690 nm was prepared. As an anion receptor, I displayed a red shift in absorption spectra and fluorescence quenching in varying degrees in the presence of F−, AcO−, H2PO4−, or Cl−. Compared with the parent calix[4]pyrrole, a representative anion receptor, I exhibited a stronger affinity to these anions due to the formation of a sandwich complex through multiple hydrogen-bonding interactions.
Customer Satisfaction and Acceptance of Relationship Marketing Concept: An Exploratory Study in QM Certified Serbian Companies
Authors: Ćoćkalo Dragan , Đorđević Dejan , Sajfert Zvonko 
Published: April 2011

Customer Satisfaction and Acceptance of Relationship Marketing Concept: An Exploratory Study in QM Certified Serbian Companies
Satisfying customers and other groups of interest is the key output of relationship marketing. This paper presents the parts of the research that had been carried out by the first quarter of 2008 which included 84 quality management (QM) certified companies and 37 experts from Republic of Serbia. The goals of the research, related to this article, were: firstly, to explain customer satisfaction from the standpoint of relationship marketing concept; secondly, to show that relationship marketing concept is/can be accepted and implemented in QM certified Serbian companies - in order to integrate customer satisfaction and realionship marketing in QM concept.
Testing the Sustainability of Growth of the LJSEX in the January 2000 to May 2010 period
Authors: Ahčan Aleš 
Published: April 2011

Testing the Sustainability of Growth of the LJSEX in the January 2000 to May 2010 period
In this paper we analyse the behaviour of the LJSEX, the main index of the Ljubljana Stock Exchange, in the period from January 2000 till May 2010. More precisely, we test for the presence of bubbles and antibubbles and try to determine whether or not a bubble could have been predicted (both the formation and the date of the bubble burst). Second, we also employ techniques used to model antibubbles to forecast the future behaviour of the LJSE index. Besides modelling index dynamics for the aforementioned period, we also seek to determine the factors that led to the bubble forming and later bursting. We find that the bubble could have been forecasted at least several months in advance. On the other hand, a very precise date of the crash seems harder to identify. By more closely analysing the interplay between interest rates, credit activity and the LJSEX, we conclude that there is a clear connection between decreasing interest rates, increased credit activity and the formation of a stock bubble. If there is a clear correlation between the early phase of a bubble and increased credit activity of the banking sector, the link between the end of the bubble and the restriction of credit activity is less pronounced. By fitting the extended antibubble model from (Johansen 1999a) we obtain the values of parameters that give us some indication of the future behaviour of the LJSEX. Based on these results we conclude that in the next few years we are likely to experience a period of increased volatility with no clear increasing or decreasing growth pattern.
Temporal Processing Abilities across Different Age Groups
Authors: Kumar U. Ajith , A.V. Sangamanatha 
Published: April 2011

Background:Psychophysical evidence indicates age-related decline over a broad range of auditory abilities. Thus, age-related deterioration in temporal processing abilities also may be expected. At issue is whether the various dimensions of temporal processing decline at the same
or at different rates across age.Purpose:To determine whether various temporal processes decline with aging and whether some are more resistant to the effects of aging than others.Study Sample:A total of 176 subjects in the age range from 20 to 85 yr participated in this
research. Subjects were divided into six cross-sectional age groups. There were 30 subjects per age decade up to 70 yr and 26 subjects in the age group >70 yr.Data Collection and Analysis:Temporal processing was evaluated using gap detection, duration discrimination, modulation
detection, and duration pattern.Results:Individuals in the 20‐30 and 30‐40 yr groups performed significantly better in all the psychoacoustic measures in comparison to other age groups. Deterioration in temporal processing began after the fourth decade of life. Deterioration
accelerated after 70 yr of age.Conclusions:There is a systematic, age-related decline in temporal processing starting from the fourth decade of life. The deficits in temporal processing observed in the present study may be related in part to the difficulties that elderly persons
encounter in noisy listening situations.
« États faillis », « États fragiles » : concepts jumelés d'une nouvelle réflexion mondiale
Authors: Gaulme François 
Published: April 2011

Les États les plus faibles de la planète sont un danger mortel, pour eux-mêmes et pour les autres. D’où le développement de recherches sur les notions d’État faible, d’État fragile, d’État failli. La période récente a valorisé la dimension sécuritaire de ces analyses. Mais si la priorité est à la reconstruction post-crise de ces États, encore faut-il s’entendre sur la nature de ce qu’il est urgent de reconstruire, bref sur les critères d’existence de l’« État normal ». politique étrangère
Morphologie de la RGPP
Authors: Bezes Philippe 
Published: April 2011

Nouvelle manifestation inédite des politiques de réforme de l’État sous la Cinquième République, la RGPP est examinée ici de manière comparative et replacée dans la trajectoire longue des dynamiques de réforme de l’administration française. Quatre dimensions constitutives permettent la comparaison : engagements des ministères transversaux (Budget, Intérieur, Fonction publique), expertise mobilisée dans les réformes, engagement des exécutifs, dispositif et répertoire de réforme. En dépit de continuités structurelles avec les politiques antérieures, la thèse défendue est que la RGPP caractérise et incarne une dynamique sans précédent de restructurations à orientations budgétaires, inspirée de modèles issus du secteur privé, influencée par des cabinets de conseil en stratégie, confortée par des consultants porteurs de systèmes d’information intégré, défendue par un ministère du budget, des comptes publics, de la fonction publique et de la réforme de l’État faisant le lien entre économies et réorganisations et portée par un leadership présidentiel valorisant la recentralisation et le contrôle politique.
Les élites de la réforme
Authors: Rouban Luc 
Published: April 2011

Elites of the Reform The RGPP Programme Review has been implemented by a specific administrative elite. This article distinguishes between three circles of innovators, which are grouped according to their involvement in the reform process and ability to influence it. The reform pursued since 2007 is supported by new networks, and the “top circle” of innovators has been extensively renewed. The article shows that the RGPP has been implemented by a very tight core network of senior civil servants. They do not have the same profile as young civil servants from the corps techniques and the middle classes who seek to use new public management methods in order to counter the power of the grands corps. Quite the contrary, they are members of the grand corps administratifs, who have acquired professional experience in the private sector and ministers’private offices. They constitute a unique network of specialists in financial matters. Their profile is thus very different from the civil servants who are members of the two other circles responsible for implementing the reform.
Potential Role of Invariant NKT Cells in the Control of Pulmonary Inflammation and CD8+ T Cell Response during Acute Influenza A Virus H3N2 Pneumonia
Authors: Paget Christophe , Ivanov Stoyan , Fontaine Josette , Blanc Fany , Pichavant Muriel , Renneson Joelle , Bialecki Emilie , Pothlichet Julien , Vendeville Catherine , Barba-Speath Giovanna , Huerre Michel-René , Faveeuw Christelle , Si-Tahar Mustapha , Trottein François 
Published: April 2011

Abstract
Influenza A virus (IAV) infection results in a highly contagious respiratory illness leading to substantial morbidity and occasionally death. In this report, we assessed the in vivo physiological contribution of invariant NKT (iNKT) lymphocytes, a subset of lipid-reactive αβ T lymphocytes, on the host response and viral pathogenesis using a virulent, mouse-adapted, IAV H3N2 strain. Upon infection with a lethal dose of IAV, iNKT cells become activated in the lungs and bronchoalveolar space to become rapidly anergic to further restimulation. Relative to wild-type animals, C57BL/6 mice deficient in iNKT cells (Jα18−/− mice) developed a more severe bronchopneumonia and had an accelerated fatal outcome, a phenomenon reversed by the adoptive transfer of NKT cells prior to infection. The enhanced pathology in Jα18−/− animals was not associated with either reduced or delayed viral clearance in the lungs or with a defective local NK cell response. In marked contrast, Jα18−/− mice displayed a dramatically reduced IAV-specific CD8+ T cell response in the lungs and in lung-draining mediastinal lymph nodes. We further show that this defective CD8+ T cell response correlates with an altered accumulation and maturation of pulmonary CD103+, but not CD11bhigh, dendritic cells in the mediastinal lymph nodes. Taken together, these findings point to a role for iNKT cells in the control of pneumonia as well as in the development of the CD8+ T cell response during the early stage of acute IAV H3N2 infection.
The Toric Geometry of Triangulated Polygons in Euclidean Space
Authors: Howard Benjamin , Manon Christopher , Millson John 
Published: April 2011

AbstractSpeyer and Sturmfels associated Gröbner toric degenerationsofwith each trivalent treehavingnleaves. These degenerations induce toric degenerationsofMr, the space ofnordered, weighted (byr) points on the projective line. Our goal in this paper is to give a geometric (Euclidean polygon) description of the toric fibers and describe the action of the compact part of the torus as “bendings of polygons”. We prove the conjecture of Foth and Hu that the toric fibers are homeomorphic to the spaces defined by Kamiyama and Yoshida.
RAPID3 (Routine Assessment of Patient Index Data 3) severity categories and response criteria: Similar results to DAS28 (Disease Activity Score) and CDAI (Clinical Disease Activity Index) in the RAPID 1 (Rheumatoid Arthritis Prevention of Structural Damage) clinical trial of certolizumab pegol
Authors: Pincus Theodore , Furer Victoria , Keystone Edward , Yazici Yusuf , Bergman Martin J. , Luijtens Kristel 
Published: April 2011

AbstractObjectiveTo compare categories for activity/severity according to the Disease Activity Score 28‐joint count (DAS28), the Clinical Disease Activity Index (CDAI), and the Routine Assessment of Patient Index Data 3 (RAPID3), an index without formal joint counts calculated in 5 versus >100 seconds, as well as the European League Against Rheumatism (EULAR)– DAS28 and the RAPID3 response criteria, in the Rheumatoid Arthritis Prevention of Structural Damage (RAPID 1) clinical trial of certolizumab pegol (CZP).MethodsPost hoc analyses were performed using correlations, cross‐tabulations, and kappa statistics. Patients (treated with CZP plus methotrexate [MTX] or placebo plus MTX) were classified at baseline and at 52 weeks as high, moderate, low activity/severity or remission, according to the DAS28 (>5.1, >3.2 to ≤5.1, 2.6 to ≤3.2, <2.6 [total range 0–10]), the CDAI (>22, >10 to ≤22, >2.8 to ≤10, ≤2.8 [total range 0–76]), and RAPID3 (>12, >6 to ≤12, >3 to ≤6, ≤3 [total range 0–30]), as well as for good, moderate, and poor EULAR‐DAS28 and proposed RAPID3 response criteria.ResultsAll measures were correlated significantly: RAPID3 with DAS28 and CDAI (rho > 0.7), higher than erythrocyte sedimentation rate with C‐reactive protein level (rho = 0.47). At 52 weeks, DAS28, CDAI, and RAPID3 low activity/remission was seen in 30%, 44%, and 42% of CZP‐treated patients versus 3%, 7%, and 10% of control patients. Good, moderate, and poor EULAR‐DAS28 responses were seen in 30%, 51%, and 19% of CZP‐treated patients versus 3%, 28%, and 70% of control patients, and for RAPID3 in 39%, 30%, and 32% of CZP‐treated patients versus 8%, 16%, and 76% of control patients. Kappa and weighted kappa values ranged from 0.36–0.53, indicating fair to moderate agreement.ConclusionRAPID3, DAS28, and CDAI give similar results to distinguish CZP patients from controls in the RAPID 1 clinical trial. DAS28 is specific for clinical trials; RAPID3 appears pragmatically useful for usual care.
Free‐Standing Patterned Ceramic Structures Obtained by Soft Micromolding
Authors: Seils Sascha , Baraki Raschid , Jamin Christine , Guillon Olivier 
Published: April 2011

AbstractPatterned ceramic films with constant thickness can be processed by a soft lithographic method. By using micromolding in capillaries, the slurry is forced to flow through channels created in an elastomer stamp. After drying, layers deposited on an amorphous carbon substrate were sintered under inert atmosphere. Free‐standing ceramic structures with high aspect ratio were obtained with lateral resolution better than 1 µm. Dimensional changes were monitored in comparison to films deposited on stiff sapphire substrate. This technique enables to process a large variety of structures, from optical or electronic components to sieve and MEMS applications.
Deletion of the immunoglobulin domain of IL1RAPL1 results in nonsyndromic X‐linked intellectual disability associated with behavioral problems and mild dysmorphism
Authors: Franek Karl J. , Butler Julia , Johnson John , Simensen Richard , Friez Michael J. , Bartel Frank , Moss Tonya , DuPont Barbara , Berry Katherine , Bauman Margaret , Skinner Cindy , Stevenson Roger E. , Schwartz Charles E. 
Published: April 2011

AbstractX‐Linked intellectual disability accounts for a significant fraction of males with cognitive impairment. Many of these males present with a non‐syndromic phenotype and presently mutations in 17 X‐linked genes are associated with these patients. Mutations in IL1RAPL1 have been found in multiple families with non‐syndromic X‐linked intellectual disability. All of the published mutations predict loss of function of the protein. We have identified an additional two families with deletions of a portion of the gene that give rise to cognitive impairment, as well as some behavioral problems and mild dysmorphism. Our clinical findings better delineate the phenotypic spectrum associated with IL1RAPL1 mutations. © 2011 Wiley‐Liss, Inc.
Left ventricular noncompaction in Sotos syndrome
Authors: Martinez Hugo R. , Belmont John W. , Craigen William J. , Taylor Michael D. , Jefferies John L. 
Published: April 2011

AbstractSotos syndrome is an autosomal dominant condition characterized by pre‐ and postnatal overgrowth (tall stature and macrocephaly), a typical facial appearance, advanced bone age, and developmental delay. The syndrome is caused by mutations or deletions of the nuclear receptor binding SET domain protein 1 (NSD1) gene, which encodes a histone methyltransferase implicated in the regulation of chromatin. Left ventricular noncompaction (LVNC), also called left ventricular (LV) hypertrabeculation, is a rare disorder classified as a primary genetic cardiomyopathy by the American Heart Association. This condition is characterized by an altered myocardial wall due to arrest of embryonic compaction of the loose interwoven meshwork that makes up the fetal myocardial primordium. The cardiac manifestations of this cardiomyopathy are variable, ranging from an absence of symptoms to a progressive deterioration in cardiac function, with heart failure, arrhythmias, and systemic thromboemboli. We describe two unrelated patients who had LVNC, as based on echocardiographic findings, and Sotos syndrome, as based on physical features and molecular analysis. To our knowledge, the literature contains no previous reports of concomitant LVNC and Sotos syndrome. In the light of these two cases, we suggest that patients with Sotos syndrome be evaluated for LVNC cardiomyopathy when being screened for heart defects. © 2011 Wiley‐Liss, Inc.