bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Formation of Christianity
Authors: Stowers Stanley 
Published: May 2024

Abstract
Using the theory of social kinds, this chapter explains how Christianity emerged from ancient Mediterranean religion. The Christian movement formed within the social field of literate and literary experts in religion from its freelance or more autonomous pole in the portion of the field occupied by Judean intellectuals writing in Greek. These figures attacked everyday religiosity as superstition and civic religion as idolatry. The social form of experts with students and nonexpert followers would form the fundamental social structure that became clergy and laity. Freelance experts like Paul, Marcion, and Justin, still operating in the field with philosophers and sophists, lost ground to experts who depended more and more on locative principles. These literate experts with power over the nonexperts/laity found it impossible to fully “educate” the nonexperts and had to constantly deal with the religion of everyday social exchange that the nonexperts could not fully leave behind. The result included the need for experts to permit practices of exchange with martyrs, saints, and the beloved dead.
In Sublimity’s Wake
Authors: Bennett William 
Published: May 2024

Abstract
This research paper comparatively assesses Deleuze’s and Lyotard’s post-Kantian thought on the sublime. Initially, I argue that their unfaithful treatment of Kant bears consonance in dramatizing the heterogeneity of the transcendental faculties, relegating determinate thought to a subsidiary consideration, and conceiving of aesthetics as an excessive mode of production rather than a reflective form of judgement. However, they diverge in the details regarding aesthetic production in their writings on modernist painting. In conclusion, I maintain that these accounts require a paradigmatic shift in thought away from determinate judgement toward a fidelity to events. The significance of drawing these two thinkers together in this regard is in the recognition and elucidation of an event-oriented ontology, whereby the subject is actively transformed through creative responses to singular events in a process of rupture and regeneration. This rests upon the postulate that reality is not exhausted by experience, and carries with it an ethical imperative to resist limiting the future to the present conditions of experience.
Breast cancer prognosis through the use of multi-modal classifiers: current state of the art and the way forward
Authors: Mathur Archana , Arya Nikhilanand , Pasupa Kitsuchart , Saha Sriparna , Roy Dey Sudeepa , Saha Snehanshu 
Published: May 2024

Abstract
We present a survey of the current state-of-the-art in breast cancer detection and prognosis. We analyze the evolution of Artificial Intelligence-based approaches from using just uni-modal information to multi-modality for detection and how such paradigm shift facilitates the efficacy of detection, consistent with clinical observations. We conclude that interpretable AI-based predictions and ability to handle class imbalance should be considered priority.
Impaired esophagogastric junction relaxation and lung transplantation outcomes
Authors: Latorre-Rodríguez Andrés R , Golla Madison , Arjuna Ashwini , Bremner Ross M , Mittal Sumeet K 
Published: May 2024

Summary
The implications of impaired esophagogastric junction relaxation (i.e. esophagogastric junction outflow obstruction and achalasia) in lung transplants recipients (LTRs) are unclear. Thus, we examined the prevalence and clinical outcomes of LTRs with an abnormally elevated integrated relaxation pressure (IRP) on high-resolution manometry before lung transplantation (LTx). After IRB approval, we reviewed data on LTRs who underwent LTx between January 2019 and August 2022 with a preoperative median IRP &gt;15 mmHg. Differences in overall survival and chronic lung allograft dysfunction (CLAD)–free survival between LTRs with a normalized median IRP after LTx (N-IRP) and those with persistently high IRP (PH-IRP) were assessed using Kaplan–Meier curves and the log-rank test. During the study period, 352 LTx procedures were performed; 44 (12.5%) LTRs had an elevated IRP before LTx, and 37 (84.1%) completed a postoperative manometry assessment (24 [70.6%] males; mean age, 65.2 ± 9.1 years). The median IRP before and after LTx was 18.7 ± 3.8 mmHg and 12 ± 5.6 mmHg, respectively (P &lt; 0.001); the median IRP normalized after LTx in 24 (64.9%) patients. Two-year overall survival trended lower in the N-IRP group than the PH-IRP group (77.2% vs. 92.3%, P = 0.086), but CLAD-free survival (P = 0.592) and rates of primary graft dysfunction (P = 0.502) and acute cellular rejection (P = 0.408) were similar. An abnormally elevated IRP was common in LTx candidates; however, it normalized in roughly two-thirds of patients after LTx. Two-year survival trended higher in the PH-IRP group, despite similar rates of primary graft dysfunction and acute cellular rejection as well as similar CLAD-free survival between the groups.
α-Synuclein pathology in Drosophila melanogaster is exacerbated by haploinsufficiency of Rop: connecting STXBP1 encephalopathy with α-synucleinopathies
Authors: Matsuoka Taro , Yoshida Hideki , Kasai Takashi , Tozawa Takenori , Iehara Tomoko , Chiyonobu Tomohiro 
Published: May 2024

Abstract
Syntaxin-binding protein 1 (STXBP1) is a presynaptic protein that plays important roles in synaptic vesicle docking and fusion. STXBP1 haploinsufficiency causes STXBP1 encephalopathy (STXBP1-E), which encompasses neurological disturbances including epilepsy, neurodevelopmental disorders, and movement disorders. Most patients with STXBP1-E present with regression and movement disorders in adulthood, highlighting the importance of a deeper understanding of the neurodegenerative aspects of STXBP1-E. An in vitro study proposed an interesting new role of STXBP1 as a molecular chaperone for α-Synuclein (αSyn), a key molecule in the pathogenesis of neurodegenerative disorders. However, no studies have shown αSyn pathology in model organisms or patients with STXBP1-E. In this study, we used Drosophila models to examine the effects of STXBP1 haploinsufficiency on αSyn-induced neurotoxicity in vivo. We demonstrated that haploinsufficiency of Ras opposite (Rop), the Drosophila ortholog of STXBP1, exacerbates compound eye degeneration, locomotor dysfunction, and dopaminergic neurodegeneration in αSyn-expressing flies. This phenotypic aggravation was associated with a significant increase in detergent-insoluble αSyn levels in the head. Furthermore, we tested whether trehalose, which has neuroprotective effects in various models of neurodegenerative disorders, mitigates αSyn-induced neurotoxicity exacerbated by Rop haploinsufficiency. In flies expressing αSyn and carrying a heterozygous Rop null variant, trehalose supplementation effectively alleviates neuronal phenotypes, accompanied by a decrease in detergent-insoluble αSyn in the head. In conclusion, this study revealed that Rop haploinsufficiency exacerbates αSyn-induced neurotoxicity by altering the αSyn aggregation propensity. This study not only contributes to understanding the mechanisms of neurodegeneration in STXBP1-E patients, but also provides new insights into the pathogenesis of α-synucleinopathies.
Depletion of protective microbiota promotes the incidence of fruit disease
Authors: Luo Xue , Sun Kai , Li Hao-Ran , Zhang Xiang-Yu , Pan Yi-Tong , Luo De-Lin , Wu Yi-Bo , Jiang Hui-Jun , Wu Xiao-Han , Ma Chen-Yu , Dai Chuan-Chao , Zhang Wei 
Published: May 2024

AbstractPlant-associated microbiomes play important roles in plant health and productivity. However, despite fruits being directly linked to plant productivity, little is known about the microbiomes of fruits and their potential association with fruit health. Here, by integrating 16S rRNA gene, ITS high-throughput sequencing data, and microbiological culturable approaches, we reported that roots and fruits (pods) of peanut, a typical plant that bears fruits underground, recruit different bacterial and fungal communities independently of cropping conditions and that the incidence of pod disease under monocropping conditions is attributed to the depletion of Bacillus genus and enrichment of Aspergillus genus in geocarposphere. On this basis, we constructed a synthetic community (SynCom) consisting of three Bacillus strains from geocarposphere soil under rotation conditions with high culturable abundance. Comparative transcriptome, microbiome profiling, and plant phytohormone signaling analysis reveal that the SynCom exhibited more effective Aspergillus growth inhibition and pod disease control than individual strain, which was underpinned by a combination of molecular mechanisms related to fungal cell proliferation interference, mycotoxins biosynthesis impairment, and jasmonic acid–mediated plant immunity activation. Overall, our results reveal the filter effect of plant organs on the microbiome and that depletion of key protective microbial community promotes the fruit disease incidence.
Deazaflavin metabolite produced by endosymbiotic bacteria controls fungal host reproduction
Authors: Richter Ingrid , Hasan Mahmudul , Kramer Johannes W , Wein Philipp , Krabbe Jana , Wojtas K Philip , Stinear Timothy P , Pidot Sacha J , Kloss Florian , Hertweck Christian , Lackner Gerald 
Published: May 2024

Abstract
The endosymbiosis between the pathogenic fungus Rhizopus microsporus and the toxin-producing bacterium Mycetohabitans rhizoxinica represents a unique example of host control by an endosymbiont. Fungal sporulation strictly depends on the presence of endosymbionts as well as bacterially produced secondary metabolites. However, an influence of primary metabolites on host control remained unexplored. Recently, we discovered that M. rhizoxinica produces FO and 3PG-F420, a derivative of the specialized redox cofactor F420. Whether FO/3PG-F420 plays a role in the symbiosis has yet to be investigated. Here, we report that FO, the precursor of 3PG-F420, is essential to the establishment of a stable symbiosis. Bioinformatic analysis revealed that the genetic inventory to produce cofactor 3PG-F420 is conserved in the genomes of eight endofungal Mycetohabitans strains. By developing a CRISPR/Cas-assisted base editing strategy for M. rhizoxinica, we generated mutant strains deficient in 3PG-F420 (M. rhizoxinica ΔcofC) and in both FO and 3PG-F420 (M. rhizoxinica ΔfbiC). Co-culture experiments demonstrated that the sporulating phenotype of apo-symbiotic R. microsporus is maintained upon reinfection with wild-type M. rhizoxinica or M. rhizoxinica ΔcofC. In contrast, R. microsporus is unable to sporulate when co-cultivated with M. rhizoxinica ΔfbiC, even though the fungus was observed by super-resolution fluorescence microscopy to be successfully colonized. Genetic and chemical complementation of the FO deficiency of M. rhizoxinica ΔfbiC led to restoration of fungal sporulation, signifying that FO is indispensable for establishing a functional symbiosis. Even though FO is known for its light-harvesting properties, our data illustrate an important role of FO in inter-kingdom communication.
Biology and life table parameters of Paralobesia viteana (Lepidoptera: Tortricidae), grown on different grape cultivars
Authors: Laiton-Jimenez Laura , Samiksha Fnu , Acevedo Flor Edith 
Published: May 2024

Abstract
The grape berry moth, Paralobesia viteana (Clemens), is an important pest of cultivated grapes in eastern North America. Damage is caused directly by larval feeding of grape clusters and indirectly by increasing fruit susceptibility to fungal and bacterial pathogens. Despite the impact of grape berry moth on grapes being widely recognized, there is a lack of understanding of the influence that different grape cultivars may have on grape berry moth development, reproduction, and population dynamics. In this study, we constructed age–stage 2-sex life tables for grape berry moth fed on 5 grape cultivars: Concord, Niagara, Riesling, Chambourcin, and Vidal, to examine the effects of diet on insect population development, survival, reproduction, and demographic parameters such as net reproductive rate, intrinsic rate of increase, finite rate of increase, and mean generation time. Our findings reveal that grape cultivar significantly influenced the neonate wandering period, larval developmental time, adult and female longevity, pupal weight, adult preoviposition period, oviposition period, mean generation time, age–stage-specific life expectancy, and reproductive value of P. viteana. However, diet type did not affect grape berry moth total fecundity or other demographic parameters. The highest female reproductive value was observed at 30–40 days of age, indicating that control tactics implemented during this time frame would have the greatest impact on reducing population increase. This study provides critical information on the effects of different grape cultivars on grape berry moth development, reproduction, and demography. These insights could lead to the development of management strategies that improve pest control and reduce economic losses in vineyards.
Fate of synthetic chemicals in the agronomic insect pest Spodoptera littoralis: experimental feeding-contact assay and toxicokinetic model
Authors: Römer Clara I , Ashauer Roman , Escher Beate I , Höfer Kristin , Muehlebach Michel , Sadeghi-Tehran Pouria , Sherborne Neil , Buchholz Anke 
Published: May 2024

Abstract
Insecticides prevent or reduce insect crop damage, maintaining crop quality and quantity. Physiological traits, such as an insect’s feeding behavior, influence the way insecticides are absorbed and processed in the body (toxicokinetics), which can be exploited to improve species selectivity. To fully understand the uptake of insecticides, it is essential to study their total uptake and toxicokinetics independent of their toxic effects on insects. We studied the toxicokinetics (TK) of insecticidally inactive test compounds incorporating agro-like structural motifs in larvae of the Egyptian cotton leafworm (Spodoptera littoralis, Lepidoptera), and their distribution across all biological matrices, using laboratory experiments and modeling. We measured Spodoptera larval behavior and temporal changes of whole-body concentrations of test compounds during feeding on treated soybean leaf disks and throughout a subsequent depuration period. Differences in the distribution of the total quantities of compounds were found between the biological matrices leaf, larva, and feces. Rate constants for uptake and elimination of test compounds were derived by calibrating a toxicokinetic model to the whole-body concentrations. Uptake and elimination rate constants depended on the physicochemical properties of the test compounds. Increasing hydrophobicity increased the bioaccumulation potential of test compounds. Incomplete quantities in larval matrices indicated that some compounds may undergo biotransformation. As fecal excretion was a major elimination pathway, the variable time of release and number of feces pellets led to a high variability in the body burden. We provide quantitative models to predict the toxicokinetics and bioaccumulation potential of inactive insecticide analogs (parent compounds) in Spodoptera.
Prediagnostic plasma proteomics profile for hepatocellular carcinoma
Authors: Zhang Xinyuan , Zhao Longgang , Ngo Long H , Dillon Simon T , Gu Xuesong , Lai Michelle , Simon Tracey G , Chan Andrew T , Giovannucci Edward L , Libermann Towia A , Zhang Xuehong 
Published: May 2024

Abstract

Objective
Proteomics may discover pathophysiological changes related to hepatocellular carcinoma, an aggressive and lethal type of cancer with low sensitivity for early stage diagnosis.

Design
We measured 1305 prediagnostic (median = 12.7 years) SomaScan proteins from 54 pairs of healthy individuals who subsequently developed hepatocellular carcinoma and matched non–hepatocellular carcinoma control individuals from the Nurses’ Health Study (NHS) and the Health Professionals Follow-up Study (HPFS). Candidate proteins were validated in the independent, prospective UK Biobank Pharma Proteomics Project (UKB-PPP).

Results
In NHS and HPFS, we identified 56 elevated proteins in hepatocellular carcinoma with an absolute fold change of more than 1.2 and a Wald test P value less than .05 in conditional logistic regression analysis. Ingenuity pathway analysis identified enrichment of pathways associated with cell viability, adhesion, proteolysis, apoptosis, and inflammatory response. Four proteins—chitinase-3-like protein 1, growth differentiation factor 15, interleukin-1 receptor antagonist protein, and E-selectin—showed strong positive associations with hepatocellular carcinoma and were thus validated by enzyme-linked immunosorbent assay (odds ratio = 2.48-14.7, all P &lt; .05) in the NHS and HPFS and by Olink platform (hazard ratio = 1.90-3.93, all P &lt; .05) in the UKB-PPP. Adding these 4 proteins to a logistic regression model of traditional hepatocellular carcinoma risk factors increased the area under the curve from 0.67 to 0.87 in the NHS and HPFS. Consistently, model area under the curve was 0.88 for hepatocellular carcinoma risk prediction in the UKB-PPP.

Conclusion
However, the limited number of hepatocellular carcinoma patients in the cohorts necessitates caution in interpreting our findings, emphasizing the need for further validation in high-risk populations.
More than meets the eye: knowns and unknowns of the trafficking of small secreted proteins in Arabidopsis
Authors: Pečenková Tamara , Potocký Martin , Stegmann Martin 
Published: May 2024

Abstract
Small proteins represent a significant portion of the cargo transported through plant secretory pathways, playing crucial roles in developmental processes, fertilization, and responses to environmental stresses. Despite the importance of small secreted proteins, substantial knowledge gaps persist regarding the regulatory mechanisms governing their trafficking along the secretory pathway, and their ultimate localization or destination. To address these gaps, we conducted a comprehensive literature review, focusing particularly on trafficking and localization of Arabidopsis small secreted proteins with potential biochemical and/or signaling roles in the extracellular space, typically those within the size range of 101–200 amino acids. Our investigation reveals that while at least six members of the 21 mentioned families have a confirmed extracellular localization, eight exhibit intracellular localization, including cytoplasmic, nuclear, and chloroplastic locations, despite the presence of N-terminal signal peptides. Further investigation into the trafficking and secretion mechanisms of small protein cargo could not only deepen our understanding of plant cell biology and physiology but also provide a foundation for genetic manipulation strategies leading to more efficient plant cultivation.
gausSN: Bayesian time-delay estimation for strongly lensed supernovae
Authors: Hayes Erin E , Thorp Stephen , Mandel Kaisey S , Arendse Nikki , Grayling Matthew , Dhawan Suhail 
Published: May 2024

ABSTRACT
We present gausSN, a Bayesian semiparametric Gaussian Process (GP) model for time-delay estimation with resolved systems of gravitationally lensed supernovae (glSNe). gausSN models the underlying light curve non-parametrically using a GP. Without assuming a template light curve for each SN type, gausSN fits for the time delays of all images using data in any number of wavelength filters simultaneously. We also introduce a novel time-varying magnification model to capture the effects of microlensing alongside time-delay estimation. In this analysis, we model the time-varying relative magnification as a sigmoid function, as well as a constant for comparison to existing time-delay estimation approaches. We demonstrate that gausSN provides robust time-delay estimates for simulations of glSNe from the Nancy Grace Roman Space Telescope and the Vera C. Rubin Observatory’s Legacy Survey of Space and Time (Rubin-LSST). We find that up to 43.6 per cent of time-delay estimates from Roman and 52.9 per cent from Rubin-LSST have fractional errors of less than 5 per cent. We then apply gausSN to SN Refsdal and find the time delay for the fifth image is consistent with the original analysis, regardless of microlensing treatment. Therefore, gausSN maintains the level of precision and accuracy achieved by existing time-delay extraction methods with fewer assumptions about the underlying shape of the light curve than template-based approaches, while incorporating microlensing into the statistical error budget. gausSN is scalable for time-delay cosmography analyses given current projections of glSNe discovery rates from Rubin-LSST and Roman.
The host dark matter haloes of the first quasars
Authors: Costa Tiago 
Published: May 2024

ABSTRACT
If z &gt; 6 quasars reside in rare, massive haloes, ΛCDM cosmology predicts they should be surrounded by an anomalously high number of bright companion galaxies. Here, I show that these companion galaxies should also move unusually fast. Using a new suite of cosmological, ‘zoom-in’ hydrodynamic simulations, I present predictions for the velocity distribution of quasar companion galaxies and its variation with quasar host halo mass at $z \, = \, 6$. Satellites accelerate as they approach the quasar host galaxy, producing a line-of-sight velocity profile that broadens with decreasing distance to the quasar host galaxy. This increase in velocity dispersion is particularly pronounced if the host halo mass is $\gtrsim 5 \times 10^{12} \, \rm M_\odot$. Typical line-of-sight speeds rise to $\approx 500 \, \rm km \, s^{-1}$ at projected radii $\sim 10 \, \rm kpc$. For about 10 per cent of satellites, they should exceed $800 \, \rm km \, s^{-1}$, with $\approx 5~{{\ \rm per\ cent}}$ of companions reaching line-of-sight speeds $\sim 1000 \, \rm km \, s^{-1}$. For lower host halo masses $\approx 5 \times 10^{11}{-}10^{12} \, \rm M_\odot$, the velocity profile of companion galaxies is significantly flatter. In this case, typical line-of-sight velocities are $\approx 250 \, \rm km \, s^{-1}$ and do not exceed $\approx 500 \, \rm km \, s^{-1}$. A comparison with existing Atacama Large Millimeter/submillimeter Array (ALMA), JWST and Multi-Unit Spectroscopic Explorer (MUSE) line-of-sight velocity measurements reveals that observed z &gt; 6 quasar companions closely follow the velocity distribution expected for a host halo with mass $\gtrsim 5 \times 10^{12} \, \rm M_\odot$, ruling out a light host halo. Finally, through an estimate of ultraviolet and [$\rm O \, {\small III}$] luminosity functions, I show that the velocity distribution more reliably discriminates between halo mass than companion number counts, which are strongly affected by cosmic variance.
China, global economic disintegration, and the climate change challenge
Authors: Garnaut Ross 
Published: May 2024

Abstract
China has a large national interest in the success of the international effort to hold human-induced increases in temperature to 1.5 degrees above pre-industrial levels—and therefore in global net emissions falling to net zero by 2050. China is essential to the success of the global effort—as a supplier of competitively priced equipment for the zero-emissions world economy and as the world’s largest current source of greenhouse gas emissions. Success is more likely for China and the world with international specialization in line with global comparative advantage in goods production for the zero-emissions economy. This requires open international trade, with China supplying equipment to and drawing zero emissions semi-processed goods from abroad. Contemporary tendencies in international political economy make that difficult but not impossible.