bluuebunny/crossref_metadata_2025_split huggingface dataset:
Knowledge hiding in organizations
Authors: Connelly Catherine E. , Zweig David , Webster Jane , Trougakos John P. 
Published: January 2011

SummaryDespite the efforts to enhance knowledge transfer in organizations, success has been elusive. It is becoming clear that in many instances employees are unwilling to share their knowledge even when organizational practices are designed to facilitate transfer. Consequently, this paper develops and investigates a novel construct, knowledge hiding. We establish that knowledge hiding exists, we distinguish knowledge hiding from related concepts (knowledge hoarding and knowledge sharing), and we develop a multidimensional measure of this construct. We also identify several predictors of knowledge hiding in organizations. The results of three studies, using different methods, suggest that knowledge hiding is comprised of three related factors: evasive hiding, rationalized hiding, and playing dumb. Each of these hiding behaviors is predicted by distrust, yet each also has a different set of interpersonal and organizational predictors. We draw implications for future research on knowledge management. Copyright © 2010 John Wiley & Sons, Ltd.
Leadership of scientists and engineers: A three‐vector model
Authors: Robledo Issac C. , Peterson David R. , Mumford Michael D. 
Published: January 2011

SummaryExisting models have not adequately accounted for the leadership of scientists and engineers engaged in creative work. In this Incubator, we present a model of creative leadership of scientists and engineers and argue that such leaders should possess expertise in three vectors. Implications and directions for future research are discussed. Copyright © 2010 John Wiley & Sons, Ltd.
Board task performance: An exploration of micro‐ and macro‐level determinants of board effectiveness
Authors: Minichilli Alessandro , Zattoni Alessandro , Nielsen Sabina , Huse Morten 
Published: January 2011

AbstractThis paper addresses recent calls to narrow the micro–macro gap in management research (Bamberger, 2008), by incorporating a macro‐level context variable (country) in exploring micro‐level determinants of board effectiveness. Following the integrated model proposed by Forbes and Milliken (1999), we identify three board processes as micro‐level determinants of board effectiveness. Specifically, we focus on effort norms, cognitive conflicts and the use of knowledge and skills as determinants of board control and advisory task performance. Further, we consider how two different institutional settings influence board tasks, and how the context moderates the relationship between processes and tasks. Our hypotheses are tested on a survey‐based dataset of 535 medium‐sized and large industrial firms in Italy and Norway, which are considered to substantially differ along legal and cultural dimensions. The findings show that: (i) Board processes have a larger potential than demographic variables to explain board task performance; (ii) board task performance differs significantly between boards operating in different contexts; and (iii) national context moderates the relationships between board processes and board task performance. Copyright © 2010 John Wiley & Sons, Ltd.
Approximate model for blunt objects indenting cohesive‐frictional materials
Authors: Hambleton J. P. , Drescher A. 
Published: January 2011

SUMMARYAn approximate two‐dimensional model for indentation of blunt objects into various types of rigid‐perfectly plastic cohesive‐frictional material is derived. Particular emphasis is placed on considering indentation as a process involving evolution of the boundary of material displaced by the indenter. Force–penetration relationships are obtained by an incremental approach utilizing key kinematic and static information from indentation of a flat punch. Albeit approximate, the proposed model applies to arbitrary indenter geometry and weightless or ponderable cohesive‐frictional materials exhibiting associated or non‐associated plastic flow. Two specific indenter geometries, the cylinder and blunt wedge, are explored in detail. Favorable agreement is found between the analytic results and those obtained using the finite element method (FEM). For both the wedge and cylinder, it is further shown that accurate analytic expressions relating indentation force explicitly to penetration can be derived. In the case of the wedge and weightless material, predictions of indentation force obtained from the derived expressions are very close to those computed from implicit equations available in the literature. Copyright © 2011 John Wiley & Sons, Ltd.
Thermo‐hydro‐mechanical modeling of damage in unsaturated porous media: Theoretical framework and numerical study of the EDZ
Authors: Arson C. , Gatmiri B. 
Published: January 2011

SUMMARYThe damage model presented in this article (named ‘THHMD’ model) is dedicated to non‐isothermal unsaturated porous media. It is formulated by means of three independent strain state variables, which are the thermodynamic conjugates of net stress, suction and thermal stress. The damage variable is a second‐order tensor. Stress/strain relationships are derived from Helmholtz free energy, which is assumed to be the sum of damaged elastic potentials and ‘crack‐closure energies’. Damage is assumed to grow with tensile strains due to net stress, with pore shrinkage due to suction and with thermal dilatation. Specific conductivities are introduced to account for the effects of cracking on the intensification and on the orientation of liquid water and vapor flows. These conductivities depend on damage and internal length parameters. The mechanical aspects of the THHMD model are validated by comparing the results of a triaxial compression test with experimental measurements found in the literature. Parametric studies of damage are performed on three different heating problems related to nuclear waste disposals. Several types of loading and boundary conditions are investigated. The thermal damage potential is thoroughly studied. The THHMD model is expected to be a useful tool in the assessment of the Excavation Damaged Zone, especially in the vicinity of nuclear waste repositories. Copyright © 2011 John Wiley & Sons, Ltd.
NGI‐ADP: Anisotropic shear strength model for clay
Authors: Grimstad Gustav , Andresen Lars , Jostad Hans P. 
Published: January 2011

SUMMARYMany geotechnical problems involve undrained behavior of clay and the capacity in undrained loading. Most constitutive models used today are effective stress based and only indirectly obtain values for the undrained shear strength. To match the design profiles of undrained shear strengths, in active (A), direct simple shear (D) and passive (P) modes of loading are complicated. This paper presents the elastoplastic constitutive model NGI‐ADP which is based on the undrained shear strength approach with direct input of shear strengths. Consequently, exact match with design undrained shear strengths profiles is obtained and the well‐known anisotropy of undrained shear strength and stiffness is accounted for in the constitutive model. A non‐linear stress path‐dependent hardening relationship is used, defined from direct input of failure strains in the three directions of shearing represented by triaxial compression, direct simple shear and triaxial extension. With its clear input parameters the model has significant advantages for design analysis of undrained problems. The constitutive model is implemented, into finite element codes, with an implicit integration scheme. Its performance is demonstrated by a finite element analysis of a bearing capacity problem. Copyright © 2011 John Wiley & Sons, Ltd.
Activation of mutated K‐ras in donor endometrial epithelium and stroma promotes lesion growth in an intact immunocompetent murine model of endometriosis
Authors: Cheng Ching‐wen , Licence Diana , Cook Emma , Luo Feijun , Arends Mark J , Smith Stephen K , Print Cristin G , Charnock‐Jones D Stephen 
Published: January 2011

AbstractEndometriosis is a common chronic gynaecological condition, affecting 5–10% of women of child‐bearing age. Its study has been hampered by lack of genetically tractable models. We transplanted steroid‐manipulated, menstrual‐like endometrium from K‐rasG12V/+/Ah‐Cre+/+/ROSA26R‐LacZ+/+ mice into gonad‐intact immunocompetent wild‐type mice. This led to endometriosis‐like lesion development. Long‐term lesion survival depended on the presence of the activated K‐ras in the small proportion of the cells in the mature lesion that had undergone Cre‐mediated K‐ras activation. LacZ activity demonstrated Cre‐mediated recombination in both endometrial epithelial cells and stromal cells, and transgenic K‐ras expression was confirmed by RT‐PCR. The endometriosis lesions developed without exogenous oestradiol supplementation and anti‐oestrogen (fulvestrant, ICI 182780) treatment greatly suppressed their growth. Immunohistochemistry confirmed that as in human endometriosis, there was invasion and activation of fibroblasts, endothelial cells, and macrophages, with marked collagen deposition in the lesions. This model provides an opportunity to investigate endometriosis lesion establishment, growth, and regression in genetically tractable, immunocompetent, and hormonally intact mice. Furthermore, for the first time it provides a suitable model to test clinically validated driver genes in a faithful mouse model of the predisposing endometriotic lesion, thus providing the correct cellular context and microenvironment for ovarian clear cell carcinogenesis. Copyright © 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Acute sensitivity of the oral mucosa to oncogenic K‐ras
Authors: van der Weyden Louise , Alcolea Maria P , Jones Philip H , Rust Alistair G , Arends Mark J , Adams David J 
Published: January 2011

AbstractMouse models of cancer represent powerful tools for analysing the role of genetic alterations in carcinogenesis. Using a mouse model that allows tamoxifen‐inducible somatic activation (by Cre‐mediated recombination) of oncogenic K‐rasG12D in a wide range of tissues, we observed hyperplasia of squamous epithelium located in moist or frequently abraded mucosa, with the most dramatic effects in the oral mucosa. This epithelium showed a sequence of squamous hyperplasia followed by squamous papilloma with dysplasia, in which some areas progressed to early invasive squamous cell carcinoma, within 14 days of widespread oncogenic K‐ras activation. The marked proliferative response of the oral mucosa to K‐rasG12D was most evident in the basal layers of the squamous epithelium of the outer lip with hair follicles and wet mucosal surface, with these cells staining positively for pAKT and cyclin D1, showing Ras/AKT pathway activation and increased proliferation with Ki‐67 and EdU positivity. The stromal cells also showed gene activation by recombination and immunopositivity for pERK indicating K‐Ras/ERK pathway activation, but without Ki‐67 positivity or increase in stromal proliferation. The oral neoplasms showed changes in the expression pattern of cytokeratins (CK6 and CK13), similar to those observed in human oral tumours. Sporadic activation of the K‐rasG12D allele (due to background spontaneous recombination in occasional cells) resulted in the development of benign oral squamous papillomas only showing a mild degree of dysplasia with no invasion. In summary, we show that oral mucosa is acutely sensitive to oncogenic K‐ras, as widespread expression of activated K‐ras in the murine oral mucosal squamous epithelium and underlying stroma can drive the oral squamous papilloma–carcinoma sequence. Copyright © 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Matrix metalloproteinase 2 attenuates brain tumour growth, while promoting macrophage recruitment and vascular repair
Authors: Tremblay Pierrot , Beaudet Marie‐Josée , Tremblay Eve , Rueda Naika , Thomas Tina , Vallières Luc 
Published: January 2011

AbstractMatrix metalloproteinase 2 (MMP2) is an extracellular protein‐degrading enzyme widely believed to be involved in the invasion of brain tumour cells. However, this assumption is mainly based on in vitro studies. By characterizing the transcriptome and in vivo properties of 20 astrocytoma cell lines, we found that the levels of MMP2 were higher in GFAP− astrocytoma cells and correlated with their ability to induce vascular changes, a common complication of malignant tumours. To study the relationship between MMP2 expression and vascular alteration, we intracerebrally implanted immunodeficient mice with human astrocytoma cells stably transduced with lentiviral vectors expressing either MMP2 or a short hairpin RNA against MMP2. We found that the tumours depleted of MMP2 were larger, contained more proliferating cells and fewer macrophages, and had a vasculature that was more destabilized and regressed with fewer capillary sprouts. In contrast, the tumours overexpressing MMP2 were smaller and showed no histological difference compared to the controls. We therefore suggest that MMP2 is not the cause of vascular atypia in malignant brain tumours, but is involved in a tissue repair response that tends to limit the growth of these tumours. This study argues against MMP2 inhibition as a therapeutic approach for brain cancer and provides a comprehensive characterization of popular astrocytoma cell lines that should help to identify alternative targets. Copyright © 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Update of environmental indicators and energy payback time of CdTe PV systems in Europe
Authors: Held Michael , Ilg Robert 
Published: January 2011

AbstractThin film technologies undergo rapid developments for increasing the module efficiencies and improving production technologies or recycling processes which affect the environmental profile of PV power generation and Energy Payback Time (EPBT). Therefore, especially for the Life Cycle Assessment (LCA) of product systems with short development cycles, the environmental profiles need to be frequently updated to ensure the representativeness and validity of the environmental assessment. The update of LCA results in this paper demonstrates that considerable improvements were reached in the environmental profile of CdTe PV power and EPBT over the last four years. Depending on the location of installation in Europe, the corresponding Greenhouse Gas (GHG) emissions of PV power for ground mounted power plants are between 19 and 30 g CO2‐equiv./kWh and between 0.7 and 1.1 years in terms of EBPT. Furthermore, for the first time, the environmental impacts due to an already applied recycling procedure of CdTe modules and it's relative contribution to the CdTe PV life cycle has been investigated. This paper presents the main approach, results and outcomes of the study. Copyright © 2011 John Wiley & Sons, Ltd.
Experimental system for current–voltage curve measurement of photovoltaic modules under outdoor conditions
Authors: Piliougine M. , Carretero J. , Mora‐López L. , Sidrach‐de‐Cardona M. 
Published: January 2011

AbstractThis paper describes an experimental system developed in the photovoltaic laboratory at the University of Málaga (Spain) to measure the current–voltage curve of photovoltaic modules under outdoor conditions. The measurement is performed in an automated way by employing commercial instruments controlled by a computer using the GPIB standard. Several modules, selected sequentially through a set of relays, are biased by a four‐quadrant power supply while a function generator synchronizes two multimeters in order to acquire voltage and current values. The measurement uncertainties were also estimated. The proposed method for synchronizing the voltage and current measurements ensures that these measurements are performed simultaneously; this means that the estimated uncertainty is lower than those obtained using other previously proposed methods. The main electrical parameters are estimated. A user‐friendly application allows the user to configure several parameters, such as bias rate, voltage, and current limits and the number of points of the curve. Copyright © 2011 John Wiley & Sons, Ltd.
Cu(In,Ga)Se2solar cell grown on flexible polymer substrate with efficiency exceeding 17%
Authors: Chirilă A. , Bloesch P. , Seyrling S. , Uhl A. , Buecheler S. , Pianezzi F. , Fella C. , Perrenoud J. , Kranz L. , Verma R. , Guettler D. , Nishiwaki S. , Romanyuk Y.E. , Bilger G. , Brémaud D. , Tiwari A.N. 
Published: January 2011

AbstractDevelopment of a Cu(In,Ga)Se2thin film solar cell on a polyimide film with a conversion efficiency of 17.1%, measured under standard test conditions at the European Solar Test Installation (ESTI) of the Joint Research Centre (JRC) of the European Commission, Ispra, is reported. The drastic improvement from the previous record of 14.1% efficiency is attributed to a more optimized compositional grading, better structural and electronic properties of the absorber layer as well as reduced reflection losses. Basic film and device properties, which led to the improvement in the efficiency record of flexible solar cells are presented for the new process and compared to the old process. Copyright © 2011 John Wiley & Sons, Ltd.
Comparative proteomic profiles of the marine cyanobacterium Trichodesmium erythraeum IMS101 under different nitrogen regimes
Authors: Sandh Gustaf , Ran Liang , Xu Linghua , Sundqvist Gustav , Bulone Vincent , Bergman Birgitta 
Published: January 2011

AbstractTrichodesmium is a marine filamentous diazotrophic cyanobacterium and an important contributor of “new” nitrogen in the oligotrophic surface waters of the tropical and sub‐tropical oceans. It is unique in that it exclusively fixes N2 at daytime, although it belongs to the non‐heterocystous filamentous segment of the cyanobacterial radiation. Here we present the first quantitative proteomic analysis of Trichodesmium erythraeum IMS101 when grown under different nitrogen regimes using 2‐DE/MALDI‐TOF‐MS. Addition of combined nitrogen (${\rm NO}_{3}^{-}$) prevented development of the morphological characteristics of the N2‐fixing cell type (diazocytes), inhibited expression of the nitrogenase enzyme subunits and consequently N2 fixation activity. The diazotrophic regime (N2 versus ${\rm NO}_{3}^{-}$ cultures) elicited the differential expression of more than 100 proteins, which represented 13.5% of the separated proteins. Besides proteins directly related to N2 fixation, proteins involved in the synthesis of reducing equivalents and the generation of a micro‐oxic environment were strongly up‐regulated, as was in particular Dps, a protein related to iron acquisition and potentially other vital cellular processes. In contrast, proteins involved in the S‐adenosylmethionine (SAM) cycle, synthesis of amino acids and production of carbon skeletons for storage and synthesis of amino acids were suppressed. The data are discussed in the context of Trichodesmium's unusual N2‐fixing physiology.
Comments on “An Essay on Contact Angle Measurements” by Strobel and Lyons
Authors: Müller Michaela , Oehr Christian 
Published: January 2011

AbstractThe potential of contact angle measurements (CAM) as an analytical tool to characterize surface treatments or modifications is often not fully exploited. Agreeing with Strobel and Lyons, comparing contact angles is often much more reasonable than comparing deduced data like surface energies, because the latter are based on models, in turn involving the influence and knowledge of intermolecular forces at the respective interfaces. For a comprehensive picture, the measurement of contact angles itself has to be considered together with the appropriate model and the available techniques to carry out CAM. An appropriate measurement procedure will be given and a brief discussion of some models to derive free surface energy from CAM.
Proteome and transcriptome profiles of a Her2/Neu‐driven mouse model of breast cancer
Authors: Schoenherr Regine M. , Kelly‐Spratt Karen S. , Lin ChenWei , Whiteaker Jeffrey R. , Liu Tao , Holzman Ted , Coleman Ilsa , Feng Li‐Chia , Lorentzen Travis D. , Krasnoselsky Alexei L. , Wang Pei , Liu Yan , Gurley Kay E. , Amon Lynn M. , Schepmoes Athena A. , Moore Ronald J. , Camp II David G. , Chodosh Lewis A. , Smith Richard D. , Nelson Peter S. , McIntosh Martin W. , Kemp Christopher J. , Paulovich Amanda G. 
Published: January 2011

AbstractPurpose: We generated extensive transcriptional and proteomic profiles from a Her2‐driven mouse model of breast cancer that closely recapitulates human breast cancer. This report makes these data publicly available in raw and processed forms, as a resource to the community. Importantly, we previously made biospecimens from this same mouse model freely available through a sample repository, so researchers can obtain samples to test biological hypotheses without the need of breeding animals and collecting biospecimens.Experimental design: Twelve datasets are available, encompassing 841 LC‐MS/MS experiments (plasma and tissues) and 255 microarray analyses of multiple tissues (thymus, spleen, liver, blood cells, and breast). Cases and controls were rigorously paired to avoid bias.Results: In total, 18 880 unique peptides were identified (PeptideProphet peptide error rate ≤1%), with 3884 and 1659 non‐redundant protein groups identified in plasma and tissue datasets, respectively. Sixty‐one of these protein groups overlapped between cancer plasma and cancer tissue.Conclusions and clinical relevance: These data are of use for advancing our understanding of cancer biology, for software and quality control tool development, investigations of analytical variation in MS/MS data, and selection of proteotypic peptides for multiple reaction monitoring‐MS. The availability of these datasets will contribute positively to clinical proteomics.
OpenMx: An Open Source Extended Structural Equation Modeling Framework
Authors: Boker Steven , Neale Michael , Maes Hermine , Wilde Michael , Spiegel Michael , Brick Timothy , Spies Jeffrey , Estabrook Ryne , Kenny Sarah , Bates Timothy , Mehta Paras , Fox John 
Published: January 2011

AbstractOpenMx is free, full-featured, open source, structural equation modeling (SEM) software. OpenMx runs within the R statistical programming environment on Windows, Mac OS–X, and Linux computers. The rationale for developing OpenMx is discussed along with the philosophy behind the user interface. The OpenMx data structures are introduced—these novel structures define the user interface framework and provide new opportunities for model specification. Two short example scripts for the specification and fitting of a confirmatory factor model are next presented. We end with an abbreviated list of modeling applications available in OpenMx 1.0 and a discussion of directions for future development.