bluuebunny/crossref_metadata_2025_split huggingface dataset:
Post‐treatment of dextromethorphan on methamphetamine‐induced drug‐seeking and behavioral sensitization in rats
Authors: Yang Pao‐Pao , Huang Eagle Yi‐Kung , Fu Yu‐Ying , Ho Tsai‐Shan , Tao Pao‐Luh 
Published: June 2012

AbstractIn our previous study, we first demonstrated a significant effect of dextromethorphan (DM) on morphine‐seeking behavior in morphine‐dependent rats, when DM was given during morphine withdrawal. Using the same conditioned place preference (CPP) paradigm modified for measuring drug‐seeking‐related behavior, we further investigated the possible effect of DM on methamphetamine (MA)‐seeking in MA‐dependent rats. Our data showed that DM could also effectively suppress the drug‐seeking behavior for MA, when administered during MA withdrawal. This suggests that DM may possess a pharmacological property to prevent drug‐seeking behavior for addictive drugs in general. To examine the action sites of DM in the brain, DM was microinjected into the VTA or the NAc, and tested for its effect on MA‐seeking during withdrawal. Both intra‐VTA and intra‐NAc injections of DM were able to block the MA‐seeking, suggesting that DM has a dual action sites. In our neurochemical results, intra‐NAc injection of DM showed a clear reduction of DA turnover rate at the NAc and the mPFC in response to MA challenge during withdrawal, which matched with the behavioral results. However, intra‐VTA injection of DM reduced the DA turnover rate at the mPFC but did not have effect on the DA turnover rate at the NAc. Although further investigations may be needed to verify the connection between our neurochemical and behavioral results, the present study highlights the therapeutic potential of DM in antidrug‐seeking behavior of MA and that the mechanism could be related to its effect on the mesolimbic and mesocortical dopaminergic pathways. Synapse 2012. © 2012 Wiley Periodicals, Inc.
Early Postoperative Vocal Function Evaluation After Thyroidectomy Using Thyroidectomy Related Voice Questionnaire
Authors: Chun Byung‐Joon , Bae Ja‐Sung , Chae Byung‐Joo , Hwang Yeon‐Shin , Shim Mi‐Ran , Sun Dong‐Il 
Published: June 2012

AbstractBackgroundThe objectives of this study were to evaluate a screening method for detecting postoperative vocal cord palsy and lower‐pitched voice and to identify how a pre‐thyroidectomy laryngeal disorder affects post‐thyroidectomy voice change by using our subjective voice questionnaire.MethodsWe examined 300 consecutive patients scheduled to undergo thyroidectomies between November 2010 and August 2011. Laryngoscopic examination, thyroidectomy‐related voice questionnaire (TVQ) administration, and acoustic and perceptual analyses were performed preoperatively and 2 weeks after thyroidectomy.ResultsNinety‐eight (32.6 %) patients had a preoperative laryngeal disorder. Postoperatively, 31 (10.3 %) patients had vocal cord palsy and 54 (18 %) had a lower‐pitched voice 2 weeks after thyroidectomy. Postoperative TVQs classified 25 (8.4 %) patients as normal and 275 (91.6 %) patients as abnormal, including 79 (26.3 %) mild, 131 (43.6 %) moderate, and 65 (21.6 %) severe cases. Of the patients with vocal cord palsy, 80.6 % belonged to the severe group, and 92.6 % of patients with lower‐pitched voices belonged to the moderate and severe groups. Fundamental frequency and speaking fundamental frequency were decreased significantly in women. The most efficient TVQ cutoff values for detecting post‐thyroidectomy vocal cord palsy and postoperative lower‐pitched voice were 35 (87.1 % sensitivity, 79.9 % specificity) and 25 (75.9 % sensitivity, 56.5 % specificity), respectively. Total TVQ scores increased more in the nonlaryngeal than in the laryngeal disorder group.ConclusionsDuring the early postoperative period, 28.3 % of patients had vocal cord palsy or lower‐pitched voices, which could be evaluated using a simple questionnaire. Therefore, early postoperative voice evaluation is important. Patients with nonlaryngeal disorders may be more sensitive than those with laryngeal disorders to laryngeal symptoms.
Evolutionary Developmental Biology (Evo-Devo): Past, Present, and Future
Authors: Hall Brian K. 
Published: June 2012

AbstractEvolutionary developmental biology (evo–devo) is that part of biology concerned with how changes in embryonic development during single generations relate to the evolutionary changes that occur between generations. Charles Darwin argued for the importance of development (embryology) in understanding evolution. After the discovery in 1900 of Mendel’s research on genetics, however, any relationship between development and evolution was either regarded as unimportant for understanding the process(es) of evolution or as a black box into which it was hard to see. Research over the past two decades has opened that black box, revealing how studies in evo–devo highlight the mechanisms that link genes (the genotype) with structures (the phenotype). This is vitally important because genes do not make structures. Developmental processes make structures using road maps provided by genes, but using many other signals as well—physical forces such as mechanical stimulation, temperature of the environment, and interaction with chemical products produced by other species—often species in entirely different kingdoms as in interactions between bacteria and squid or between leaves and larvae (Greene Science 243:643–666, 1989). Not only do genes not make structures (the phenotype), but new properties and mechanisms emerge during embryonic development: genes are regulated differentially in different cells and places; aggregations of similar cells provide the cellular resources (modules) from which tissues and organs arise; modules and populations of differently differentiated cells interact to set development along particular tracks; and organisms interact with their environment and create their niche in that environment. Such interactions are often termed “epigenetic,” meaning that they direct gene activity using mechanisms that are not encoded in the DNA of the genes. This paper reviews the origins of evo–devo, how the field has changed over the past 30 years, evaluates the recognition of the importance for development and evolution of mechanisms that are not encoded in DNA, and evaluates what the future might bring for evo–devo. Although impossible to know, history tells us that we might expect more of the same; expansion of evo–devo into other areas of biology (ecology, physiology, behavior); absorption of evo–devo by evolution or a unification of biology in which evo–devo plays a major role.
Embeddedness and empathy: How the social network shapes adolescents' social understanding
Authors: Wölfer Ralf , Cortina Kai S. , Baumert Jürgen 
Published: June 2012

ABSTRACTBased on theories of social‐cognitive development, the present study investigated the yet unknown social structure that underlies the concept of empathy in adolescence. A total of 3.159 seventh graders (13.67 years, 56% girls) from 166 school classes participated by providing information on empathy, related psychosocial factors, and friendship patterns. Social network analyses were used to measure a comprehensive representation of adolescents' social environment by covering individual, group, class, and school characteristics. Multilevel models revealed that individual characteristics as well as contextual factors predict adolescents' level of empathy. Findings indicate that empathy is mirrored in the social structure of adolescents supporting the hypothesis that social demands, which continuously grow with the amount of embeddedness, shape their social understanding.
Invariants birationnels dans la suite spectrale de Bloch-Ogus
Authors: Pirutka Alena 
Published: June 2012

AbstractFor a fieldkof cohomological dimension d we prove that the groups, (l, car.k) = 1, are birational invariants of smooth projective geometrically integral varieties overkof dimensionn. Using the Kato conjecture, which has been recently established by Kerz and Saito [18], we obtain a similar result over a finite field for the groups. We relate one of these invariants with the cokernel of the l-adic cycle class map, which gives an analogue of a result of Colliot-Thélène and Voisin [5] 3.11 over ℂ for varieties over a finite field.
Reynolds-stress-constrained large-eddy simulation of wall-bounded turbulent flows
Authors: Chen Shiyi , Xia Zhenhua , Pei Suyang , Wang Jianchun , Yang Yantao , Xiao Zuoli , Shi Yipeng 
Published: June 2012

AbstractIn the traditional hybrid RANS/LES approaches for the simulation of wall-bounded fluid turbulence, such as detached-eddy simulation (DES), the whole flow domain is divided into an inner layer and an outer layer. Typically the Reynolds-averaged Navier–Stokes (RANS) equations are used for the inner layer, while large-eddy simulation (LES) is used for the outer layer. The transition from the inner-layer solution to the outer-layer solution is often problematic due to the lack of small-scale dynamics in the RANS region. In this paper, we propose to simulate the whole flow domain by large-eddy simulation while enforcing a Reynolds-stress constraint on the subgrid-scale (SGS) stress model in the inner layer. Both the algebraic eddy-viscosity model and the one-equation Spalart–Allmaras (SA) model have been used to constrain the Reynolds stress in the inner layer. In this way, we improve the LES methodology by allowing the mean flow of the inner layer to satisfy the RANS solution while small-scale dynamics is included. We validate the Reynolds-stress-constrained large-eddy simulation (RSC-LES) model by simulating three-dimensional turbulent channel flow and flow past a circular cylinder. Our model is able to predict mean velocity, turbulent stress and skin-friction coefficients more accurately in turbulent channel flow and to estimate the pressure coefficient after separation more precisely in flow past a circular cylinder compared with the pure dynamic Smagorinsky model (DSM) and DES using the same grid resolution. Furthermore, the computational cost of the RSC-LES is almost the same as that of DES.
Fostering a new industry in the Industrial Revolution: Boulton & Watt and gaslight 1800–1812
Authors: TOMORY LESLIE 
Published: June 2012

AbstractGaslight emerged as a new industry after 1800 in Britain, but not in other countries in Europe where the technology existed as well. Among the many groups trying, it was only the firm of Boulton & Watt that succeeded in commercializing the invention for two important reasons. The first was that they possessed skills and experience related to ironworking and to making scientific instruments, both of which they used as they developed gaslight apparatus. This development involved an extensive series of experiments that ultimately had its root in James Watt's own work with pneumatic chemistry. The second reason was that they possessed many resources such as access to capital, their existing network of industrial customers, and their abilities to publicize their work. As with the steam engine, the firm proved adept at advertising. Boulton & Watt did not give their full attention to gaslight except in two spurts between 1805 and 1809, and by around 1812 they had lost almost all interest in the technology. By this time, however, they had solved many problems associated with scaling up gaslight apparatus for industrial use, they had trained many people who would go on to do further important work in the early years of the industry, and they had drawn extensive public attention to the new invention. Finally, their advertising involved elevating the status of William Murdoch as an inventor while minimizing the role of the firm.
EFFECTS OF AGE, ETHNICITY AND HEALTH BEHAVIOURS ON THE PREVALENCE OF ADVERSE BIRTH OUTCOMES IN TAIWAN
Authors: WANG SHU-CHUAN , LEE MUNG-CHIH 
Published: June 2012

SummaryThis study sampled 8432 singleton first live births from Taiwan's 2005 Birth Registration Database to determine if there were more pre-term or low birth weight deliveries among aboriginal women than there were among Han Chinese women, and if the ‘weathering’ hypothesis applied to aboriginal women in Taiwan. Although the aboriginal women were socially disadvantaged and engaged in more unhealthy behaviours, including smoking, drinking, chewing betel quid and exposure to second-hand smoke, the evidence did not support the hypothesis that these teenaged minority women would have better birth outcomes, as has been demonstrated among teenage African-American women in the United States. Behaviours and not ethnicity were risk factors for teenage aboriginal mothers, who started deleterious health behaviours earlier than did their older counterparts. Teenage mothers had more adverse outcomes regardless of ethnicity and aboriginal mothers had more risky behaviours in all age groups. The prevalence of detrimental health behaviour among teenage mothers in Taiwan is of concern, particularly for aboriginal teenage mothers.
Leverage Expectations and Bond Credit Spreads
Authors: Flannery Mark J. , Nikolova Stanislava (Stas) , Öztekin Özde 
Published: June 2012

AbstractIn an efficient market, spreads will reflect both the issuer’s current risk and investors’ expectations about how that risk might change over time. Collin-Dufresne and Goldstein (2001) show analytically that a firm’s expected future leverage importantly influences the spread on its bonds. We use capital structure theory to construct proxies for investors’ expectations about future leverage changes and find that these significantly affect bond yields, above and beyond the effect of contemporaneous leverage. Expectations under the trade-off, pecking order, and credit-rating theories of capital structure all receive empirical support, suggesting that investors view them as complementary when pricing corporate bonds.
On the Nature of Ancient Letter Collections
Authors: Gibson Roy 
Published: June 2012

AbstractThere exists a strong link in modern thinking between letter collections and biographical or historical narration. Many ancient letter collections have been rearranged by modern editors along chronological lines, apparently with the aim of realizing the biographical and historiographical potential of these ancient collections. In their original format, however, non-fictional Greco-Roman letter collections were arranged predominantly by addressee or by theme (often without the preservation of chronology within addressee or thematic groupings), or they might be arranged on the principle of artful variety and significant juxtaposition. Consequently, some purpose or purposes other than biographical or historical narration must be attributed to ancient letter collections. This paper asks what those purposes might be.
The Testament of Vibius Adiranus
Authors: McDonald Katherine 
Published: June 2012

AbstractThis article reconsiders one of the best-known examples of Oscan epigraphy — the inscription which commemorates the testament of Vibius Adiranus to thevereiia-of Pompeii. It has been widely accepted that this inscription is a first-centurya.d.copy of a second-centuryb.c.original, and is therefore the latest extant example of Oscan in a formal public inscription. This is challenged here with an analysis of both the linguistic detail and archaeological context, and it is shown that this inscription itself is more likely to be the original. The re-dating suggested here has implications for our understanding of language use at Pompeii; it also facilitates more accurate estimates of when the deaths of the Italic languages took place.
Parametrizations of sub-attractors in hyperbolic balance laws
Authors: Ehrt Julia 
Published: June 2012

We investigate the properties of the global attractor of hyperbolic balance laws on the circle, given byut + f(u)x = g(u).The new tool of sub-attractors is introduced. They contain all solutions on the global attractor up to a given number of zeros. The paper proves finite dimensionality of all sub-attractors, provides a full parametrization of all sub-attractors and derives a system of ordinary differential equations for the embedding parameters that describe the full partial differential equation dynamics on the sub-attractor.
Antimicrobial resistance to benzylpenicillin in invasive pneumococcal disease in Belgium, 2003–2010: the effect of altering clinical breakpoints
Authors: GOOSSENS M. C. , CATRY B. , VERHAEGEN J. 
Published: June 2012

SUMMARYThe Belgian data (2003–2010) for the European Antimicrobial Resistance Surveillance Network (EARS-Net) showed a significant decreasing trend in the proportion of penicillin non-susceptibleStreptococcus pneumoniae(9·4% to <1%) from blood and CSF isolates. We found that 75% of this decrease was explained by a change in Clinical and Laboratory Standards Institute (CLSI) breakpoints as the trend disappeared if only the new breakpoints were applied. Applying only European Committee on Antimicrobial Susceptibility Testing (EUCAST) breakpoints also resulted in a relatively stable proportion of penicillin non-susceptibility (average 5%), but this proportion was 7–13 times higher than with the new CLSI breakpoints. When the new CLSI breakpoints alone are used, fewer than 1% of bacteraemia isolates were penicillin non-susceptible during the entire period, but the proportion of non-susceptible meningitis isolates rose from 6·3% in 2003 to 15·9% between 2003 and 2010. Changing breakpoints should lead to retrospective analysis of historical data to minimize wrongly interpreting resistance trends.
COLLECTIVE DESTIGMATIZATION AND EMANCIPATION THROUGH LANGUAGE IN 1960s QUÉBEC
Authors: Bouchard Gérard 
Published: June 2012

AbstractIn the history of Québec, the 1960s are known as the time of the Quiet Revolution. That decade is commonly referred to as a major watershed since it marked the onset of a spectacular economic, social, and cultural recovery of the Francophone (“French Canadian”) population. Previously, and for two centuries, Francophone Québec had been dominated by the British Empire and English Canada. Throughout the period, as a cultural minority, it had borne the brunt of ethnoracial stereotypes and had suffered from discrimination in the workplace. I seek to investigate one dimension of the destigmatizing process that unfolded in the 1960s by focusing on the discursive strategies devised by a group of young leftist intellectuals who argued that Francophone Québec needed a new national language as a condition of its full emancipation. My research focuses on major contradictions that this radical group had to confront: 1) they could have rejected the vernacular, stigmatized language (known asjoual) emblematic of the English domination, to adopt the Parisian French and thus become fully part of a great civilization, but by doing so they would have lapsed into another form of colonization since this superior language was considered as foreign and imposed at the expense of “authenticity”; and 2) they could have promotedjoualas the authentic language of the nation and worked to free it from stigma, but this would have come at the price of a “parochialization” of Québec culture. I show that these intellectuals failed to invent the collective myths that would have transcended this double bind and other contradictions. Finally, the paper compares Québec to other societies in the New World in order to better highlight the distinctiveness of this case.
ALL RESPONSES ARE NOT CREATED EQUAL
Authors: Bickerstaff Jovonne J. 
Published: June 2012

AbstractThis exploratory study makes a contribution to the literature on antiracism by analyzing how first-generation French Blacks of sub-Saharan African descent practice everyday antiracism. In doing so, it expands the demographic terrain of this research to highlight some particularities in the experience of everyday racism and antiracism for ethnoracial minorities ofimmigrant origins. In addition to experiencing forms of racism encountered by both immigrants and other native ethnoracial minorities, first-generation French Blacks (like other non-White first-generation Europeans), face symbolic exclusion from the national community and delegitimization of their claims to Europeanness. Examining their experiences sheds light on how race, immigration, and national identity intersect to generate unique experiences of racism and antiracism. This paper also contributes to our understanding of how social context shapes the range of everyday antiracist strategies at a person's disposal. Specifically, integrating Kasinitz et al.'s (2008) framework for categorizing incidents of racial discrimination and prejudice with Fleming et al.'s (2010) categorization of responses to stigmatization, I present an analysis of antiracist responses that takes into account both the nature of the relationship between the victim and the perpetrator of racism (i.e., impersonal vs. personal) and the social context in which the encounter occurs (e.g., school, work, public space, etc). In doing so, I highlight how the conditions of a given incident of racism or discrimination set constraints on the range of antiracist responses an individual can practically (or feasibly) employ.
WHAT WE FACE
Authors: Hirsch Nicole Arlette , Jack Anthony Abraham 
Published: June 2012

AbstractWhile many sociological studies analyze the causes, conditions, and mechanisms perpetuating American racial inequality, the literature on how African Americans understand and explain these inequalities is less developed. Drawing on 150 interviews with middle-class and working-class African American men and women, this paper analyzes inductively how respondents define and conceptualize the most pressing obstacles facing their group when probed on this question. We find that middle- and working-class respondents alike identify the problem of racism as the most salient obstacle facing African Americans. Class differences appear with respect to what other obstacles are singled out as salient: while middle-class respondents focus on lack of racial solidarity among Blacks and economic problems (in this order), working-class respondents are more concerned with the fragility of the Black family followed by the lack of racial solidarity. This analysis discusses the relevance of considering how groups make sense of obstacles, and of racism and discrimination in particular, for the study of destigmatization and antiracist strategies of stigmatized minorities.
Public governance of healthcare in the United States: a transaction costs economics (TCE) analysis of the 2010 reform
Authors: SPITHOVEN ANTOON 
Published: June 2012

Abstract:This article aims to address the lack of transaction costs economics (TCE) studies in health economics. It provides a content analysis of ObamaCare and 25 lawsuits that challenge the 2010 reform. It shows that the cultural environment determines the strength of features of governance structures and in line with this the strength of their instruments. Following Williamson's TCE model of governance structures, the zero transaction costs criterion is supplanted by the remediableness criterion. Assuming that ObamaCare might be ruled to be constitutional, the regulation of healthcare is found to be a comparative efficient governance structure in addressing adverse selection. However, the TCE analysis also reveals that ObamaCare itself is subject to some flaws in efficiency and effectiveness, namely: unbalanced adaptation mechanisms, unbalanced incentives and weak enforcement devices.