bluuebunny/crossref_metadata_2025_split huggingface dataset:
Regulating Sodium Deposition Behavior by a Triple‐Gradient Framework for High‐Performance Sodium Metal Batteries
Authors: Cao Weishan , Liu Mengyue , Song Weihao , Li Zhen , Li Bingyang , Wang Pengfei , Fisher Adrian , Niu Jin , Wang Feng 
Published: June 2024

AbstractAn efficient method for the synthesis of a self‐supporting carbon framework (denoted Gra‐GC‐MoSe2) is proposed with a triple‐gradient structure—in sodiophilic sites, pore volume, and electrical conductivity—which facilitates the highly efficient regulation of Na deposition. In situ and ex situ measurements, together with theoretical calculations, reveal that the gradient distribution of Se heteroatoms in MoSe2, and its derivatives tailor the sodiophilicity, while the gradient distribution of porous nanostructures homogenizes the Na+ diffusion. Therefore, Na deposition occurs from the bottom to the top of the Gra‐GC‐MoSe2 framework without dendrite formation. In addition, the gradient in electrical conductivity ensures the stripping process does not lead to dead Na. As a result, a Gra‐GC‐MoSe2 modified Na anode (Na@Gra‐GC‐MoSe2) shows impressive cycling stability with a high average Coulombic efficiency in an asymmetric cell. In symmetric cells, it also exhibits a long cycling life of 2000 h with a low polarization voltage and works stably even under a large capacity of 10 mAh cm−2. Moreover, a Na@Gra‐GC‐MoSe2|| Na3V2(PO4)3 full cell delivers a high energy density with an excellent cycling performance.
Rapid Synthesis and Microenvironment Optimization of Hierarchical Porous Fe─N─C Catalysts for Enhanced ORR in Microbial Fuel Cells
Authors: Jiang Bolong , Jiang Nan , Cui Yanyan , Wang Huan , Zhang Geng , Li Jiayou , Zhang Yuhan 
Published: June 2024

AbstractHere, an approach to produce a hierarchical porous Fe‐N‐C@TABOH catalyst with densely accessible high intrinsic active FeNx sites is proposed. The method involves a single‐step pyrolysis of Zn/Fe‐zeolitic imidazolate framework (Zn/Fe‐ZIF‐H) with tetrabutylammonium hydroxide (TABOH) micelles, which is obtained by utilizing TABOH as a structural template and electronic mediator at room temperature for a brief duration of 16 min. Notably, the yield of Zn/Fe‐ZIF‐H is 3.5 times that of Zn/Fe‐ZIF‐N prepared by conventional method. Results indicate that in addition to expediting synthesis and increasing yield of the Zn/Fe‐ZIF‐H, the TABOH induces a hierarchical porous structure and fosters the formation of more and higher intrinsic active FeNx moieties in Fex‐N‐C@TABOH, showing that TABOH is a multifunctional template. Crucially, the increased mesoporosity/external surface area and optimized microenvironment of Fe‐N‐C@TABOH significantly enhance ORR activity by facilitating the formation of high intrinsic active FeNx sites, increasing accessible FeNx sites, and reducing mass transfer resistance. Through structure tailoring and microenvironment optimization, the resulting Fe‐N‐C@TABOH exhibits superior ORR performance. DFT calculation further validates that the synergistic effect of these two factors leads to low ORR barrier and optimized *OH adsorption energy. This study underscores the importance of structure and electronic engineering in the development of highly active ORR catalysts.
Bis(pinacolato)diboron‐Enabled Ni‐Catalyzed Reductive Arylation/Vinylation of Alkyl Electrophiles
Authors: Sun Deli , Gong Yuxin , Wu Yu , Chen Yunrong , Gong Hegui 
Published: June 2024

AbstractHerein, the use of economically and environmentally friendly bis(pinacolato)diboron (B2Pin2) is described as a non‐metallic reductant in mediating Ni‐catalyzed C(sp3)–C(sp2) reductive cross‐coupling of alkyl electrophiles with aryl/vinyl halides. This method exhibits excellent suitability for heteroaryl halides and alkyl halides/Katritzky salts. The present study is compatible with an in situ halogenation of alcohol method, allowing for selective mono‐functionalization of diols and bio‐relevant alcohols (e.g., carbohydrates). The use of B2Pin2 shows potential for easy scalability without introducing additional metal impurities into the products. It is observed for the first time in the realm of cross‐electrophile coupling chemistry that B2Pin2 can sever as a reductant to reduce NiII to Ni0. This mechanistic insight may inspire the development of new reductive bond‐forming methodologies that can otherwise be difficult to achieve with a metal reductant.
Head‐to‐Head Comparison of Tau and Amyloid Positron Emission Tomography Visual Reads for Differential Diagnosis of Neurodegenerative Disorders: An International, Multicenter Study
Authors: Soleimani‐Meigooni David N. , Smith Ruben , Provost Karine , Lesman‐Segev Orit H. , Allen Isabel Elaine , Chen Miranda K. , Cho Hanna , Edwards Lauren , Janelidze Shorena , La Joie Renaud , Mundada Nidhi , Ossenkoppele Rik , Stomrud Erik , Strandberg Olof , Strom Amelia , Boxer Adam L. , Dage Jeffrey L. , Gorno‐Tempini Maria Luisa , Kramer Joel H. , Miller Bruce L. , Rojas Julio C. , Rosen Howard J. , Lyoo Chul H. , Hansson Oskar , Rabinovici Gil D. 
Published: June 2024

ObjectiveWe compared the accuracy of amyloid and [18F]Flortaucipir (FTP) tau positron emission tomography (PET) visual reads for distinguishing patients with mild cognitive impairment (MCI) or dementia with fluid biomarker support of Alzheimer's disease (AD).MethodsParticipants with FTP‐PET, amyloid‐PET, and diagnosis of dementia‐AD (n = 102), MCI‐AD (n = 41), non‐AD diseases (n = 76), and controls (n = 20) were included. AD status was determined independent of PET by cerebrospinal fluid or plasma biomarkers. The mean age was 66.9 years, and 44.8% were women. Three readers interpreted scans blindly and independently. Amyloid‐PET was classified as positive/negative using tracer‐specific criteria. FTP‐PET was classified as positive with medial temporal lobe (MTL) binding as the minimum uptake indicating AD tau (tau‐MTL+), positive with posterolateral temporal or extratemporal cortical binding in an AD‐like pattern (tau‐CTX+), or negative. The majority of scan interpretations were used to calculate diagnostic accuracy of visual reads in detecting MCI/dementia with fluid biomarker support for AD (MCI/dementia‐AD).ResultsSensitivity of amyloid‐PET for MCI/dementia‐AD was 95.8% (95% confidence interval 91.1–98.4%), which was comparable to tau‐CTX+ 92.3% (86.7–96.1%, p = 0.67) and tau‐MTL+ 97.2% (93.0–99.2%, p = 0.27). Specificity of amyloid‐PET for biomarker‐negative healthy and disease controls was 84.4% (75.5–91.0%), which was like tau‐CTX+ 88.5% (80.4–94.1%, p = 0.34), and trended toward being higher than tau‐MTL+ 75.0% (65.1–83.3%, p = 0.08). Tau‐CTX+ had higher specificity than tau‐MTL+ (p = 0.0002), but sensitivity was lower (p = 0.02), driven by decreased sensitivity for MCI‐AD (80.5% [65.1–91.2] vs. 95.1% [83.5–99.4], p = 0.03).InterpretationAmyloid‐ and tau‐PET visual reads have similar sensitivity/specificity for detecting AD in cognitively impaired patients. Visual tau‐PET interpretations requiring cortical binding outside MTL increase specificity, but lower sensitivity for MCI‐AD. ANN NEUROL 2024;96:476–487
Quinolone bioisosteres of phenolic GluN2B‐selective NMDA receptor antagonists
Authors: Rathing Friederike , Schepmann Dirk , Wünsch Bernhard 
Published: June 2024

AbstractCyclopenta[g]quinolones of type 4 were designed with the aim to bioisosterically replace the phenol of potent GluN2B ligands such as ifenprodil and Ro 25‐6981 by the quinolone system and to restrict the conformational flexibility of the aminopropanol substructure in a cyclopentane system. The designed ligands were synthesized in an eight‐step sequence starting with terephthalaldehyde (5). Key steps pf the synthesis were the intramolecular Friedel–Crafts acylation of propionic acids 10 to yield the cyclopenta[g]quinolinediones 11 and the Mannich reaction of diketone 11a followed by conjugate addition at the α,β‐unsaturated ketone 12a. Although the quinolones 13a, 15a, and 16a contain an H‐bond donor group (secondary lactam) as ifenprodil and Ro 25‐6981, they show only moderate GluN2B affinity (Ki > 410 nM). However, the introduction of lipophilic substituents at the quinolone N‐atom resulted in more than 10‐fold increased GluN2B affinity of the benzyl and benzyloxymethyl derivatives cis‐13c (Ko = 36 nM) and 13e (Ko = 27 nM). All compounds are selective over the phencyclidine (PCP) binding site of the N‐methyl‐D‐aspartate (NMDA) receptor. The benzyl derivative 13c showed six‐ and threefold selectivity over σ1 and σ2 receptors, respectively.
Security control of direct current microgrids under deception attacks—A dynamic event‐triggered approach
Authors: Li Fuqiang , Li Kang , Peng Chen , Gao Lisai 
Published: June 2024

AbstractThis paper studies the security control of direct current (DC) microgrids under deception attacks, and a dynamic event‐triggered mechanism (DETM) is proposed to save constrained network bandwidth. The DETM can reduce the frequency of data communications and exclude Zeno behavior inherently. Then, a time‐delay closed‐loop system model is built, which integrates parameters of the DC microgrid, the DETM, deception attacks, injection current controller, and network‐induced delays in one unified framework. Sufficient conditions are derived for globally exponentially ultimately bounded stability in mean square, which establish the relationship between system performance and the contributing factors such as the DETM, deception attacks, and network delays. Further, a co‐design method is presented to derive the parameters of the controller and the DETM in just one step. Simulation results confirm the effectiveness of the proposed method for security control of DC microgrids, achieving 21.5% savings of communication resources while effectively stabilizing the system even 10.7% of the transmitted data that are manipulated by the deception attacks.
Seven‐degree‐of‐freedom‐based electric wheel sampled‐data active shimmy control method considering unknown sensor measurement error
Authors: Meng Qinghua , Liu Rong , Sun Zong‐yao , He Haibin 
Published: June 2024

AbstractThe active shimmy control methods for electric vehicle driven by in‐wheel motors (EV‐DIM) have been proposed in the recent years. However, these methods assume that data obtained from sensors are accurate, despite the fact that sensor measurements are prone to error. This unknown measurement error can make shimmy control difficult. Additionally, current shimmy models are low degree‐of‐freedom, which simplifies control but decreases accuracy. In this paper, we address these issues using a sampled‐data output control method based on a higher seven‐degree‐of‐freedom (7DOF) shimmy model which includes the steering system, suspension, and electric wheel. We first construct a 7DOF electric wheel shimmy model and use Lagrange's theorem to derive the electric wheel shimmy dynamic equations. We then obtain system state equations that account for unknown sensor measurement error based on the 7DOF shimmy model. A sampled‐data observer and controller are designed to attenuate or eliminate the shimmy phenomenon via a domination gain. Finally, we conduct numerical simulations and experiments to verify the effectiveness of our proposed method.
The flavonoid quercetin decreases ACE2 and TMPRSS2 expression but not SARS‐CoV‐2 infection in cultured human lung cells
Authors: Houghton Michael James , Balland Eglantine , Gartner Matthew James , Thomas Belinda Jane , Subbarao Kanta , Williamson Gary 
Published: June 2024

AbstractSevere acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) binds to angiotensin‐converting enzyme 2 (ACE2) on host cells, via its spike protein, and transmembrane protease, serine 2 (TMPRSS2) cleaves the spike‐ACE2 complex to facilitate virus entry. As rate‐limiting steps for virus entry, modulation of ACE2 and/or TMPRSS2 may decrease SARS‐CoV‐2 infectivity and COVID‐19 severity. In silico modeling suggested the natural bioactive flavonoid quercetin can bind to ACE2 and a recent randomized clinical trial demonstrated that oral supplementation with quercetin increased COVID‐19 recovery. A range of cultured human cells were assessed for co‐expression of ACE2 and TMPRSS2. Immortalized Calu‐3 lung cells, cultured and matured at an air–liquid interface (Calu‐3‐ALIs), were established as the most appropriate. Primary bronchial epithelial cells (PBECs) were obtained from healthy adult males (N = 6) and cultured under submerged conditions to corroborate the outcomes. Upon maturation or reaching 80% confluence, respectively, the Calu‐3‐ALIs and PBECs were treated with quercetin, and mRNA and protein expression were assessed by droplet digital PCR and ELISA, respectively. SARS‐CoV‐2 infectivity, and the effects of pre‐ and co‐treatment with quercetin, was assessed by median tissue culture infectious dose assay. Quercetin dose‐dependently decreased ACE2 and TMPRSS2 mRNA and protein in both Calu‐3‐ALIs and PBECs after 4 h, while TMPRSS2 remained suppressed in response to prolonged treatment with lower doses (twice daily for 3 days). Quercetin also acutely decreased ADAM17 mRNA, but not ACE, in Calu‐3‐ALIs, and this warrants further investigation. Calu‐3‐ALIs, but not PBECs, were successfully infected with SARS‐CoV‐2; however, quercetin had no antiviral effect, neither directly nor indirectly through downregulation of ACE2 and TMPRSS2. Calu‐3‐ALIs were reaffirmed to be an optimal cell model for research into the regulation of ACE2 and TMPRSS2, without the need for prior genetic modification, and will prove valuable in future coronavirus and respiratory infectious disease work. However, our data demonstrate that a significant decrease in the expression of ACE2 and TMPRSS2 by a promising prophylactic candidate may not translate to infection prevention.
Fabrication of bacterial cellulose/PVP nanofiber composites by electrospinning
Authors: Cesur Nevra Pelin , Zad Ghaffari Vahdat Kosar , Türkoğlu Laçin Nelisa 
Published: June 2024

AbstractThis study aimed to address a significant challenge in the application of bacterial cellulose (BC) within tissue engineering and regenerative medicine by tackling its inherent insolubility in water and organic solvents. Our team introduced a groundbreaking approach by utilizing zinc sulfate (ZnSO4) as a solvent to render BC soluble, a novel contribution to the literature. Subsequently, the obtained soluble BC was combined with varying concentrations of polyvinylpyrrolidone (PVP). Notably, we pioneered the fabrication of BC/PVP composite scaffolds with customizable fiber surface morphology and regulated degradation rates through the electrospun technique. Several key parameters, such as PVP concentration (8%, 15%, 12%, and 20% w/v), applied voltage (22, 15, and 12 kV), and a fixed nozzle‐collector distance of 10 cm with a flow rate of 0.9 mL/h, were systematically evaluated so as to find the optimum parameter created BC/PVP product with electrospun. For electrospun BC/PVP products, a voltage of 12 kV was found to be optimal. Intriguingly, our findings revealed enhanced cell adhesion and proliferation in BC/PVP electrospun products compared with using PVP membranes alone. Specifically, cell viability for PVP and PVP/BC electrospun products was determined as 50.73% and 79.95%, respectively. In terms of thermal properties, the BC/PVP electrospun product exhibited a mass loss of 82.6% at 380°C, while PVP alone experienced 90.2% mass loss at around 280°C. Furthermore, the protein adhesion capacities were measured at 62.3 ± 1.2 μg for PVP and 99.4 ± 2 μg for BC/PVP electrospun products, whereas product showed no biodegradation over 28 days and had notable water retention capacity. In conclusion, our research not only successfully attained nanofiber morphology but also showcased enhanced cell attachment and proliferation on the BC/PVP electrospun product.
Vapor‐phase synthesis of MOF films
Authors: Choe Myeonggeun , Lee Hyeonwoo , Choi Hee Cheul 
Published: June 2024

AbstractFabrication of thin films is the most crucial step in introducing promising new materials into practical devices. Among the various materials, metal–organic framework (MOF) thin films have gained widespread attention with the advantage of diverse applications. In this review, two representative vapor‐phase synthetic methods, (1) molecular layer deposition (MLD), (2) chemical vapor deposition (CVD) are addressed as emerging techniques.
Post‐synthetic modifications of MOF‐74 type frameworks for enhancing CO2 capture and moisture stability
Authors: Kurisingal Jintu Francis , Choe Jong Hyeak , Kim Hyojin , Youn Jeongwon , Cheon Gayoung , Hong Chang Seop 
Published: June 2024

AbstractAnthropogenic carbon dioxide (CO2) emissions pose a significant threat to the delicate balance between human society and the natural environment. Carbon capture and sequestration is a technology designed to selectively capture CO2 emissions generated from power plants and industrial facilities, preventing them from entering the atmosphere. Diamine‐modified metal–organic frameworks (MOFs) show promising capabilities in achieving remarkable CO2 capacities, highlighting their potential for effective CO2 capture applications. Herein, using MOF‐74 type frameworks, we discussed our various methodologies designed to enhance the CO2 adsorption capacity, while also tackling the issue of maintaining structural integrity over prolonged periods, especially in humid environments. The challenges and prospects for CO2 capture by diamine‐functionalized hydrophobic MOFs are highlighted.
Sorption and mobility assessment of tembotrione in soils of upper, trans and middle Gangetic plain zones of India
Authors: Ghoshal Debabrata , Dixit Mahima , Narayanan Neethu , Saini Priya , Kumar Aman , Banerjee Tirthankar , Singh Neera , Gupta Suman 
Published: June 2024

AbstractThe presence of undesired agrochemicals residues in soil and water poses risks to both human health and the environment. The behavior of pesticides in soil depends both on the physico‐chemical properties of pesticides and soil type. This study examined the adsorption–desorption and leaching behavior of the maize herbicide tembotrione in soils of the upper (UGPZ), trans (TGPZ) and middle Gangetic plain zones of India. Soil samples were extracted using acetone followed by partitioning with dichloromethane, whereas liquid–liquid extraction using dichloromethane was used for aqueous samples. Residues of tembotrione and its metabolite TCMBA, {2‐chloro‐4‐(methylsulfonyl)‐3‐[(2,2,2‐trifluoroethoxy) methyl] benzoic acid}, were quantified using liquid chromatography–tandem mass spectrometry. The data revealed that tembotrione adsorption decreased with increasing pH and dissolved organic matter but increased with salinity. The maximum adsorption occurred at pH 4, 0.01 m sodium citrate and 4 g/L NaCl, with corresponding Freundlich constants of 1.83, 2.28 and 3.32, respectively. The hysteresis index <1 indicated faster adsorption than desorption. Leaching studies under different flow conditions revealed least mobility in UGPZ soil and high mobility in TGPZ soil, consistent with groundwater ubiquity scores of 4.27 and 4.81, respectively. Soil amendments decreased tembotrione mobility in the order: unamended > wheat straw ash > wheat straw > farm yard manure > compost. The transformation of tembotrione to TCMBA and its mobility in soil columns were also assessed.
Gender‐affirming surgeries for transgender and gender diverse individuals and associated health outcomes
Authors: Rezaei Shawheen J. , Miller Amitai S. , Miranda Noah , Ganor Oren 
Published: June 2024

AbstractGender‐affirming care is treatment that recognizes and affirms the gender identity of transgender and gender‐diverse (TGD) individuals. Though not all TGD people choose to surgically transition, gender‐affirming surgeries (GAS) are an important part of many TGD people's transition. GAS can include a wide array of procedures aimed at aligning an individual's physical characteristics and gender identity. This review describes the most common procedures considered to be GAS, detailing important relevant considerations for each procedure. These include transfeminine procedures (i.e., breast augmentation, penile inversion vaginoplasty, orchiectomy, tracheal shave, and facial feminization); transmasculine procedures (i.e., chest masculinization, hysterectomy, phalloplasty, and metoidioplasty); and other procedures (i.e., fertility preservation and hair removal). Patient outcomes and the legal landscape for GAS are also discussed to contextualize these procedures within largest discourses surrounding gender‐affirming care.
Revisiting beta‐2 microglobulin as a prognostic marker in diffuse large B‐cell lymphoma
Authors: Jelicic Jelena , Juul‐Jensen Karen , Bukumiric Zoran , Runason Simonsen Mikkel , Roost Clausen Michael , Ludvigsen Al‐Mashhadi Ahmed , Schou Pedersen Robert , Bjørn Poulsen Christian , Ortved Gang Anne , Brown Peter , El‐Galaly Tarec Christoffer , Larsen Thomas Stauffer 
Published: June 2024

AbstractBackgroundSeveral clinical prognostic models for diffuse large B‐cell lymphoma (DLBCL) have been proposed, including the most commonly used International Prognostic Index (IPI), the National Comprehensive Cancer Network IPI (NCCN‐IPI), and models incorporating beta‐2 microglobulin (β2M). However, the role of β2M in DLBCL patients is not fully understood.MethodsWe identified 6075 patients with newly diagnosed DLBCL treated with immunochemotherapy registered in the Danish Lymphoma Registry.ResultsA total of 3232 patients had data available to calculate risk scores from each of the nine considered risk models for DLBCL, including a model developed from our population. Three of four models with β2M and NCCN‐IPI performed better than the International Prognostic Indexes (IPI, age‐adjusted IPI, and revised IPI). Five‐year overall survival for high‐ and low‐risk patients were 43.6% and 86.4% for IPI and 34.9% and 96.2% for NCCN‐IPI. In univariate analysis, higher levels of β2M were associated with inferior survival, higher tumor burden (advanced clinical stage and bulky disease), previous malignancy and increased age, and creatinine levels. Furthermore, we developed a model (β2M‐NCCN‐IPI) by adding β2M to NCCN‐IPI (c‐index 0.708) with improved discriminatory ability compared to NCCN‐IPI (c‐index 0.698, p < 0.05) and 5‐year OS of 33.1%, 56.2%, 82.4%, and 96.4% in the high, high‐intermediate, low‐intermediate and low‐risk group, respectively.ConclusionInternational Prognostic Indices, except for NCCN‐IPI, fail to accurately discriminate risk groups in the rituximab era. β2M, a readily available marker, could improve the discriminatory performance of NCCN‐IPI and should be re‐evaluated in the development setting of future models for DLBCL.