bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of extreme meteorological factors and high air pollutant concentrations on the incidence of hand, foot and mouth disease in Jining, China
Authors: Cao Haoyue , Xu Rongrong , Liang Yongmei , Li Qinglin , Jiang Wenguo , Jin Yudi , Wang Wenjun , Yuan Juxiang 
Published: May 2024

Background
The evidence on the effects of extreme meteorological conditions and high air pollution levels on incidence of hand, foot and mouth disease (HFMD) is limited. Moreover, results of the available studies are inconsistent. Further investigations are imperative to elucidate the specific issue.

Methods
Data on the daily cases of HFMD, meteorological factors and air pollution were obtained from 2017 to 2022 in Jining City. We employed distributed lag nonlinear model (DLNM) incorporated with Poisson regression to explore the impacts of extreme meteorological conditions and air pollution on HFMD incidence.

Results
We found that there were nonlinear relationships between temperature, wind speed, PM2.5, SO2, O3 and HFMD. The cumulative risk of extreme high temperature was higher at the 95th percentile (P95th) than at the 90th percentile(P90th), and the RR values for both reached their maximum at 10-day lag (P95th RR = 1.880 (1.261–2.804), P90th RR = 1.787 (1.244–2.569)), the hazardous effect of extreme low temperatures on HFMD is faster than that of extreme high temperatures. The cumulative effect of extreme low wind speeds reached its maximum at 14-day lag (P95th RR = 1.702 (1.389-2.085), P90th RR = 1.498(1.283–1.750)). The cumulative effect of PM2.5 concentration at the P90th was largest at 14-day lag (RR = 1.637 (1.069–2.506)), and the cumulative effect at the P95th was largest at 10-day lag (RR = 1.569 (1.021–2.411)). High SO2 concentration at the P95th at 14-day lag was associated with higher risk for HFMD (RR: 1.425 (1.001–2.030)).

Conclusion
Our findings suggest that high temperature, low wind speed, and high concentrations of PM2.5 and SO2 are associated with an increased risk of HFMD. This study not only adds insights to the understanding of the impact of extreme meteorological conditions and high levels of air pollutants on HFMD incidence but also holds practical significance for the development and enhancement of an early warning system for HFMD.
Assessment of Cefuroxime and Cefuroxime Clavulanic Acid Prescription Practices for Infection Management in Routine Indian Healthcare Settings: Expert Insights
Authors: Manjula S  , Krishna Kumar M  
Published: May 2024

Background: Cefuroxime axetil has shown effectiveness as part of intravenous/oral sequential therapy for community-acquired pneumonia (CAP) treatment, although some countries currently lack dosage recommendations for this regimen. In addition, the perspectives of clinicians were not studied. So, this study evaluated the prescription practice of cefuroxime, and cefuroxime+ clavulanic acid in the management of infections in routine Indian settings.
Methods: The cross-sectional survey, titled ‘Cefuroxime & Cefuroxime+Clavulanic acid in Management of Infections: Expert Perspective (CARE) Study’, utilized a 20-item, multiple-response questionnaire to gather expert opinion from specialists regarding the clinical use of cefuroxime and cefuroxime + clavulanic acid in managing infections. The survey encompassed questions about current prescription practices, clinical observations, preferences, and experiences related to the use of these antibiotics in routine settings.
Results: Among the 164 clinicians surveyed, 78% of the respondents indicated that cefuroxime was highly effective in managing lower respiratory tract infections. Additionally, 91% of the experts stated that the combination of cefuroxime and clavulanic acid was very effective in managing infections. The majority of clinicians recommended cefuroxime + clavulanic acid as the initial therapy for complicated urinary tract infections (88%), as well as first-line therapy for uncomplicated skin and soft tissue infections (45%) and community-acquired pneumonia (58%). According to 40% of the clinicians, cefuroxime + clavulanic acid was recommended as the initial therapy for 21-30% of patients suspected of methicillin-resistant Staphylococcus aureus infection. Most respondents (88%) preferred cefuroxime + clavulanic acid as the antibiotic for managing Pseudomonas aeruginosa infection.
Conclusion: The survey has emphasized the critical role of cefuroxime and cefuroxime + clavulanic acid as antibiotics in managing diverse infections. Clinicians' recognition of their efficacy and preference for combination therapy has underscored the importance of antibiotic stewardship in optimizing patient care.
Non‐Corrosive, Non‐Absorbing Organic Redox Couple for Dye‐Sensitized Solar Cells
Authors: Li Dongmei , Li Hong , Luo Yanhong , Li Kexin , Meng Qingbo , Armand Michel , Chen Liquan 
Published: August 2010

AbstractA new colorless electrolyte containing an organic redox couple, tetramethylthiourea (TMTU) and its oxidized dimer tetramethylformaminium disulfide dication ([TMFDS]2+), is applied to dye‐sensitized solar cells (DSCs). Advantages of this redox couple include its non‐corrosive nature, low cost, and easy handling. More impressively, it operates well with carbon electrodes. The DSCs fabricated with a lab‐made HCS‐CB carbon counter‐electrode can present up to 3.1% power conversion efficiency under AM 1.5 illumination of 100 mW·cm−2 and 4.5% under weaker light intensities. This result distinctly outperforms the identical DSCs with a Pt electrode. Corrosive experiments reveal that Al and stainless steel (SS) sheets are stable in the [TMFDS]2+/TMTU‐based electrolyte. Its electrochemical impedance spectrum (EIS) is used to evaluate the influence of different counter‐electrodes on the cell performance, and preliminary investigations reveal that carbon electrodes with large surface areas and ideal corrosion‐inertness toward the sulfur‐containing [TMFDS]2+/TMTU redox couple exhibit promise for application in iodine‐free DSCs.
Mikrofluidik in der anorganischen Chemie
Authors: Abou‐Hassan Ali , Sandre Olivier , Cabuil Valérie 
Published: August 2010

AbstractIn den letzten Jahren hat die Mikrofluidik in der Chemie stark an Bedeutung gewonnen. Miniaturisierte chemische Vorrichtungen ermöglichen einen kontrollierten Flüssigkeitstransport und schnelle chemische Reaktionen und sind darüber hinaus Kosten sparend, wenn man sie mit konventionellen Reaktoren vergleicht. Sowohl in der (Bio‐)Analytik als auch in der organischen Synthese werden diese Vorteile bereits ausgiebig genutzt, weniger hingegen in der anorganische Chemie und den Materialwissenschaften. Dennoch wird diese Thematik auch in der Anorganik bei der Entwicklung von Mikroreaktoren für die Trennung und selektive Extraktion von Metallionen gestreift. Bei Funktionsmaterialien wird die Mikrofluidik hauptsächlich für Verbesserungen in der Synthese von Nanopartikeln (besonders von Metall‐, Metalloxid‐ und Halbleiternanopartikeln) eingesetzt. Mikrofluidiktechniken können auch für die Entwicklung von komplizierteren anorganischen (Hybrid‐)Materialien genutzt werden.
Porenwasserdruckakkumulation bei zyklisch horizontal belasteten Monopiles mit großen Durchmessern
Authors: Ta&&num;351;an H. Ercan , Rackwitz Frank , Savidis Stavros 
Published: August 2010

AbstractMonopiles mit Durchmessern von bis zu 8 m werden als eine geeignete Gründungsmöglichkeit für Offshore‐Windenergieanlagen (OWEA) in bis zu 40 m Wassertiefe angesehen. Durch die zyklischen Horizontalbelastungen, insbesondere aus Wind und Wellengang, finden Porenwasserdruckakkumulationen im Boden statt, die bei der Dimensionierung der Monopiles derzeit nicht berücksichtigt werden.In diesem Beitrag wird das Verhalten der Monopiles von OWEA mit Fokussierung auf die Porenwasserdruckentwicklung für das Bemessungsszenario Extrembedingungen mittels numerischer Berechnungen untersucht. In den FE‐Berechnungen wird ein Zwei‐Phasen‐Modell in Verbindung mit einem hypoplastischen Stoffgesetz für den wassergesättigten Sandboden verwendet. Es werden die Ergebnisse von Parameterstudien präsentiert, die eine Variation von Belastungsamplitude, ‐frequenz, ‐zyklenanzahl und ‐typ, Lagerungsdichte und Durchlässigkeitsbeiwert des Sandes sowie den Durchmesser des Monopiles umfassen.Die eigenen Ergebnisse werden den in der Literatur vorhandenen Berechnungsansätzen zur Abschätzung des Verhaltens von zyklisch horizontal belasteten Monopiles gegenübergestellt. Es wird der Einfluss von Porenwasserdruckakkumulationen auf das interaktive Trag‐ und Verformungsverhalten des Monopile‐Boden‐Systems beurteilt und die Relevanz für die Bemessungspraxis aufgezeigt.Pore water pressure accumulation due to cyclic horizontally loaded monopiles with large diameters. Monopiles, i. e. single piles with large diameter of up to 8 m, are suitable foundations for off shore‐wind power plants built in up to 40 m water depth. Cyclic loading of the monopile‐soil system induced by extremely strong wind and water waves causes a change in pore water pressure. Current design practice does not account for such effects. In this paper the interaction behaviour of monopile‐soil systems subjected to extreme loading is analyzed using a finite element model. A fully coupled two‐phase model and a hypoplastic constitutive model for the sandy soil are used in the numerical analyses. Results from the numerical studies are presented and they include the variation of loading amplitude, frequency, number of cycles and loading type as well, initial density and permeability of the sand as well as the diameter of the monopile.The own numerical results are compared with design equations for cyclic horizontally loaded piles from other references. Based on these investigations the importance and relevance of the consideration of pore water pressure accumulation with monopilesoil systems subjected to offshore loading conditions is demonstrated.
Zur Berechnung von Holz‐Beton‐Verbundträgern mit Methoden der mathematischen Optimierung
Authors: Rautenstrauch Karl , Raue Erich , Timmler Hans‐Georg , Schröter Hendrik , Simon Antje 
Published: August 2010

AbstractHolz‐Beton‐Verbundkonstruktionen weisen als hybride Tragwerke gegenüber reinen Holz‐ bzw. Stahlbetonkonstruktionen zahlreiche Vorteile auf. Wesentlich für die Effizienz der Hybridbauweise ist die Ausbildung der Verbundfuge. Der vorliegende Beitrag stellt ein neues Verbundelement für Straßenbrücken in Holz‐Beton‐Verbundbauweise vor, welches im Rahmen eines Forschungsprojekts an der Bauhaus‐Universität Weimar entwickelt wurde. Die rechnerische Analyse der Verbundkonstruktion erfolgt — abweichend von den im Hybridbau bisher üblichen Berechnungsmethoden — unter Anwendung von Energiemethoden und Nutzung von Algorithmen der mathematischen Optimierung.Calculation of timber‐concrete composite structures using mathematical optimization methods. Timber‐concrete composite structures have many advantages over conventional timber and re inforced concrete structures. The efficiency of such hybrid structures significantly depends on the properties of the com posite joint. This article presents a novel structural element for the joint of timber‐concrete composite bridges, which was developed as part of a research project at the Bauhaus‐Universität Weimar. In contrast to standard calculation methods, an energy method and the mathematical optimization is applied for the numerical analysis of the hybrid structure.
A research‐inspired laboratory sequence investigating acquired drug resistance
Authors: Taylor Elizabeth Vogel , Fortune Jennifer A. , Drennan Catherine L. 
Published: August 2010

AbstractHere, we present a six‐session laboratory exercise designed to introduce students to standard biochemical techniques in the context of investigating a high impact research topic, acquired resistance to the cancer drug Gleevec. Students express a Gleevec‐resistant mutant of the Abelson tyrosine kinase domain, the active domain of an oncogenic protein implicated in chronic myelogenous leukemia, and investigate the kinase activity of wild type and mutant enzyme in the presence of two cancer drugs. Techniques covered include protein expression, purification, and gel analysis, kinase activity assays, and protein structure viewing. The exercises provide students with a hands‐on understanding of the impact of biochemistry on human health, and demonstrate their potential as the next generation of investigators.
A series of molecular dynamics and homology modeling computer labs for an undergraduate molecular modeling course
Authors: Elmore Donald E. , Guayasamin Ryann C. , Kieffer Madeleine E. 
Published: August 2010

AbstractAs computational modeling plays an increasingly central role in biochemical research, it is important to provide students with exposure to common modeling methods in their undergraduate curriculum. This article describes a series of computer labs designed to introduce undergraduate students to energy minimization, molecular dynamics simulations, and homology modeling. These labs were created as part of a one‐semester course on the molecular modeling of biochemical systems. Students who completed these activities felt that they were an effective component of the course, reporting improved comfort with the conceptual background and practical implementation of the computational methods. Although created as a component of a larger course, these activities could be readily adapted for a variety of other educational contexts. As well, all of these labs utilize software that is freely available in an academic environment and can be run on fairly common computer hardware, making them accessible to teaching environments without extensive computational resources.
Cation transport coupled to ATP hydrolysis by the (Na, K)‐ATPase
Authors: Leone Francisco A. , Furriel Rosa P. M. , McNamara John C. , Horisberger Jean D. , Borin Ivana A. 
Published: August 2010

AbstractAn Adobe® animation is presented for use in undergraduate Biochemistry courses, illustrating the mechanism of Na+ and K+ translocation coupled to ATP hydrolysis by the (Na, K)‐ATPase, a P2c‐type ATPase, or ATP‐powered ion pump that actively translocates cations across plasma membranes. The enzyme is also known as an E1/E2‐ATPase as it undergoes conformational changes between the E1 and E2 forms during the pumping cycle, altering the affinity and accessibility of the transmembrane ion‐binding sites. The animation is based on Horisberger's scheme that incorporates the most recent significant findings to have improved our understanding of the (Na, K)‐ATPase structure–function relationship. The movements of the various domains within the (Na, K)‐ATPase α‐subunit illustrate the conformational changes that occur during Na+ and K+ translocation across the membrane and emphasize involvement of the actuator, nucleotide, and phosphorylation domains, that is, the “core engine” of the pump, with respect to ATP binding, cation transport, and ADP and Pi release.
Isoelectric point, electric charge, and nomenclature of the acid–base residues of proteins
Authors: Maldonado Andrés A. , Ribeiro João M. , Sillero Antonio 
Published: August 2010

AbstractThe main object of this work is to present the pedagogical usefulness of the theoretical methods, developed in this laboratory, for the determination of the isoelectric point (pI) and the net electric charge of proteins together with some comments on the naming of the acid‐base residues of proteins
Problem‐based test: An in vitro experiment to analyze the genetic code
Authors: Szeberényi József 
Published: August 2010

AbstractTerms to be familiar with before you start to solve the test: genetic code, translation, synthetic polynucleotide, leucine, serine, filter precipitation, radioactivity measurement, template, mRNA, tRNA, rRNA, aminoacyl‐tRNA synthesis, ribosomes, degeneration of the code, wobble, initiation, and elongation of protein synthesis, initiation codon
ChemInform Abstract: Observation of Uniaxial Structures of Underpotentially Deposited Cadmium on Au(111) with in situ Scanning Tunneling Microscopy.
Authors: BONDOS J. C. , GEWIRTH A. A. , NUZZO R. G. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Desilylation and a One‐Pot Desilylation‐Oxidation of Aliphatic tert‐ Butyldimethylsilyl Ethers Using Catalytic Quantities of PdCl2(CH3CN)2.
Authors: WILSON N. S. , KEAY B. A. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Preparation of Nα‐Boc 4‐O‐Diethylphospho‐L‐azatyrosine, a Reagent Potentially Useful for the Synthesis of Signal Transduction Related Peptides.
Authors: YE B. , OTAKA A. , BURKE T. R. JUN. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Mechanism of Kharash Reaction Catalyzed by Fe(CO)5. Part 2. Reinvestigation of Stereochemistry of BrCCl3 Addition to Methyl N‐ Acryloyl‐(S)‐prolinate.
Authors: TARAROV V. I. , SAVEL'EVA T. F. , BELOKON' YU. N. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Cobalt Schiff Base Complex‐Catalyzed Oxidation of Anilines with tert‐ Butyl Hydroperoxide.
Authors: FOERSTER S. , RIEKER A. , MARUYAMA K. , MURATA K. , NISHINAGA A. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Reductive Deamination of Aromatic Amines with Nitric Oxide (NO).
Authors: ITOH T. , MATSUYA Y. , NAGATA K. , OHSAWA A. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Reductive O‐ and N‐Alkylations. Alternative Catalytic Methods to Nucleophilic Substitution.
Authors: FACHE F. , BETHMONT V. , JACQUOT L. , LEMAIRE M. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: DNA Cleavage of Novel Propargylic Sulfones. Enhancement of Potency via Intercalating Interaction
Authors: DAI W.‐M. , FONG K. C. , DANJO H. , NISHIMOTO S. , SOLOW M. , MAK W. L. , YEUNG M. L. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Zinc(II)‐Catalyzed Transformation of Epoxides to Aziridines.
Authors: KUEHNAU D. , THOMSEN I. , JOERGENSEN K. A. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: 1,1‐Diphenoxy‐2‐(phenylsulfonyl)cyclopropane as a Furan Annulating Agent.
Authors: POHMAKOTR M. , TAKAMPON A. , RATCHATAPHUSIT J. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Generation of Isothiazole Analogues of o‐Quinodimethane from Isothiazolo‐3‐sulfolenes.
Authors: TSO H.‐H. , CHANDRASEKHARAM M. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Perfluoroperhydro‐7,10‐diazaphenanthrene
Authors: MAKAROV K. N. , POPOVA O. A. , LANTSEVA L. T. , MUKHIN V. YU. , MYSOV E. I. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of 1,3,4,5‐Tetrahydro‐2‐benzoxepin Derivatives as Conformationally Restricted Analogues of Cyclamenaldehyde‐Type Compounds and as Intermediates for Highly Odor‐Active Homologues.
Authors: SKOUROUMOUNIS G. , WINTER B. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Mimicking the Vancomycin Carboxylate Binding Site: Synthetic Receptors (I) and (II) for Sulfonates, Carboxylates, and N‐Protected α‐ Amino Acids in Water.
Authors: HINZEN B. , SEILER P. , DIEDERICH F. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: SO3‐Mediated Reaction of Phenylselenenamide with 1,2‐ Alkadienylphosphonates.
Authors: ALABUGIN I. V. , BREL' V. K. , ZYK N. V. , ZEFIROV N. S. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.