bluuebunny/crossref_metadata_2025_split huggingface dataset:
On-Road Vehicle Aerodynamics with the Ring-of-Fire Concept
Authors: Hüttig Steffen , Kühn Malte , Gericke Timo , Bloem Guus , Sciacchitano Andrea , Akkermans Rinie A.D. 
Published: May 2024

Abstract

This paper presents the first full-scale particle image velocimetry (PIV) measurements to analyze the complete flow field of a car under real driving conditions. The Ring of Fire (RoF) measurement concept, introduced by Terra et al. (Exp Fluids 58:83, 2017 https://doi.org/10.1007/s00348-017-2331-0), is adapted to automotive demands to validate CFD simulations for further improvements of vehicle aerodynamics. The experiment consists of a tunnel setup, where neutrally buoyant helium-filled soap bubbles are used as flow tracers and are illuminated by two high-speed lasers; four high-speed cameras captured the particles motion in two separate Stereo-PIV-configurations with fields of view of 1.3 x 0.6 m2 and 2.8 x 2.2 m2. Data for a Volkswagen up!, while driving on a test track at a constant speed of 33.33 m/s was acquired and processed with standard multi-pass PIV algorithms, in order to quantify the flow field and estimate limits of the described measurement principle for on-road car aerodynamics. The resulting velocity fields are compared with CFD-simulations, showing agreement for the here considered cases within 9.65 - 6.97%, based on the root-mean-square error between the experimental and the numerical results. Furthermore, drag calculation from the obtained velocity fields based on moment conservation is performed and the percent difference to wind tunnel measurements reaches values below 3.0%.
A CNN-based approach for 3D artefact correction of intensity diffraction tomography images
Authors: PIERRÉ WILLIAM , BRIARD MATÉO , DESISSAIRE SYLVIA , DHELLEMMES MAGALI , LLANO EDGAR DEL , LOEUILLET CORINNE , RAY PIERRE F. , ARNOULT CHRISTOPHE , ALLIER CÉDRIC , HERVÉ LIONEL , PAVIOLO CHIARA 
Published: May 2024

Abstract

3D reconstructions after tomographic imaging often suffer from elongation artifacts due to the limited-angle acquisitions. The retrieval of the original 3D shape is not an easy task, mainly due to the intrinsic morphological changes that biological objects undergo during their development. Here we present a novel approach for the correction of 3D artifacts after 3D reconstructions of intensity-only tomographic acquisitions. The method relies on a network architecture that combines a volumetric and a 3D finite object approach. The framework was applied on time-lapse images of a mouse preimplantation embryo developing from fertilization to the blastocyst stage, proving the correction of the axial elongation, the recovery of the spherical objects and improved quantitative refractive index values. This work paves the way for novel directions on a generalized non-supervised pipeline suited for different biological samples and imaging conditions.
A Successive Refinement for Solving Stochastic Programs with Decision-Dependent Random Capacities
Authors: Medal Hugh , Affar Samuel 
Published: May 2024

Abstract

We study a class of two-stage stochastic programs in which the second stage includes a set of components with uncertain capacity, and the expression for the distribution function of the uncertain capacity includes first-stage variables. Thus, this class of problems has the characteristics of a stochastic program with decision-dependent uncertainty. A natural way to formulate this class of problems is to enumerate the scenarios and express the probability of each scenario as a product of the first-stage decision variables; unfortunately, this formulation results in an intractable model with a large number of variable products with high-degree. After identifying structural results related to upper and lower bounds and how to improve these bounds, we present a successive refinement algorithm that successively and dynamically tightens these bounds. Implementing the algorithm within a branch-and-cut method, we report the results of computational experiments that indicate that the successive refinement algorithm significantly outperforms a benchmark approach. Specifically, results show that the algorithm finds an optimal solution before the refined state space become too large.
Mathematics Subject Classification (2020) 90-08 · 90-10
Inhibition of type I interferon signalling is involved in the anti-atherogenic effects of Andrographis paniculata
Authors: Liu Mingchao , Liu Fangfang , Alsherbiny Muhammad A. , Li Xuejie , Huang Yajie , Yan Feng , Wang Yuan , Li Chunguang , Jiang Fan , Cheng Wen 
Published: May 2024

Abstract

Andrographis paniculata (Burm. f.) Wall. ex Nees (AP) is a medicinal herb widely used in many Asian countries. Andrographolide, the best-characterised bioactive compound in AP, has been shown to have beneficial effects against atherosclerosis. However, there is little information about the effects and underlying mechanisms of the whole AP plant on the development of atherosclerosis. To address this question, we treated apolipoprotein E-deficient mice (on a cholesterol-enriched diet) with AP decoction via dietary supplementation. The biological mechanisms were studied in mouse primary peritoneal macrophages treated with crude serum preparations isolated from normal rats receiving vehicle or AP decoction treatment. We demonstrated that AP significantly reduced the plaque area in both thoracic and abdominal aortas in mice. In macrophage cells, genome-wide mRNA sequencing revealed that AP reversed ~ 70% of the genes responsive to lipopolysaccharides. Further bioinformatics analysis indicated that AP inhibited type I interferon (IFN) signalling. In mouse aortas and lipopolysaccharides-challenged macrophages, we confirmed that AP downregulated the expression of a panel of genes comprising the core modules in the type I IFN signalling. In particular, western blot experiments in macrophage cells demonstrated that AP significantly reduced the total protein level of signal transducer and activator of transcription 1 (STAT1), while IFN-β-induced STAT1 phosphorylation was not changed. In conclusion, given the established pathogenic effects of type I IFN in atherosclerosis, our results suggest that inhibition of the type I IFN signalling in macrophages is partly involved in the anti-atherogenic effects of Andrographis paniculata.
Green Routes to Dimethyl Carbonate: A Green and Versatile Methylating Reactant
Authors: Mota Claudio J.A. 
Published: May 2024

Abstract:
This mini-review reports the current routes used for the production of dimethyl
carbonate (DMC), a green and versatile methylating reactant widely used in organic synthesis.
The use of DMC in methylation processes is also discussed. The main routes of DMC
production, encompassing the reaction between phosgene and methanol and the oxidative
carbonylation of methanol with CO and urea methanolysis, are summarised. However, none
of them can be considered entirely green, and the drawbacks in terms of green chemistry
principles are addressed. The present commercial route to DMC, which involves the initial
reaction of CO2 with ethylene oxide to produce ethylene carbonate that further reacts with
excess methanol, is also explored regarding the green chemistry principles. Moreover, this
review focuses on the direct DMC production from the reaction of methanol and CO2, discussing
catalysts and strategies to shift equilibrium. An emphasis is given to heterogeneous
catalysts, especially those based on CeO2. A final remark on the production of DMC through the capture of CO2
using chitosan-derived adsorbents and renewable methanol is addressed.
Cellular and Molecular Mechanisms of Neuronal Degeneration in Early-Stage Diabetic Retinopathy
Authors: Callan Andrew , Jha Sonal , Valdez Laura , Tsin Andrew 
Published: May 2024

Background:
Studies on the early retinal changes in Diabetic Retinopathy (DR) have
demonstrated that neurodegeneration precedes vascular abnormalities like microaneurysms or intraretinal
hemorrhages. Therefore, there is a growing field of study to analyze the cellular and
molecular pathways involved to allow for the development of novel therapeutics to prevent the
onset or delay the progression of DR.

Molecular Mechanisms:
Oxidative stress and mitochondrial dysfunction contribute to neurodegeneration
through pathways involving polyol, hexosamine, advanced glycation end products, and
protein kinase C. Potential interventions targeting these pathways include aldose reductase inhibitors
and protein kinase C inhibitors. Neurotrophic factor imbalances, notably brain-derived neurotrophic
factor and nerve growth factor, also play a role in early neurodegeneration, and supplementation
of these neurotrophic factors show promise in mitigating neurodegeneration.

Cellular Mechanisms:
Major cellular mechanisms of neurodegeneration include caspase-mediated
apoptosis, glial cell reactivity, and glutamate excitotoxicity. Therefore, inhibitors of these pathways
are potential therapeutic avenues.

Vascular Component:
The nitric oxide pathway, critical for neurovascular coupling, is disrupted
in DR due to increased reactive oxygen species. Vascular Endothelial Growth Factor (VEGF), a
long-known angiogenic factor, has demonstrated both damaging and neuroprotective effects,
prompting a careful consideration of long-term anti-VEGF therapy.

Conclusion:
Current DR treatments primarily address vascular symptoms but fall short of preventing
or halting the disease. Insights into the mechanisms of retinal neurodegeneration in the setting
of diabetes mellitus not only enhance our understanding of DR but also pave the way for future
therapeutic interventions aimed at preventing disease progression and preserving vision.
Saudi National Clinical Practice Guidelines for Management of Adult Systemic Lupus Erythematosus
Authors: Al-Jedai Ahmed H. , Almudaiheem Hajer Y. , Al-Homood Ibrahim A. , Almaghlouth Ibrahim , Bahlas Sami M. , Alolaiwi Abdulaziz Mohammed , Fatani Mohammad , Eshmawi Maysa Tariq , AlOmari Bedor A. , Alenzi Khalidah Ahmed , Albarakati Rayan G. , Al Ghanim Nayef 
Published: May 2024

Objective:
To provide evidence-based clinical practice recommendations for managing
Systemic Lupus Erythematosus (SLE) in Saudi Arabia.

Methods:
This EULAR-adapted national guideline in which a multidisciplinary task force utilized
the modified Delphi method to develop 31 clinical key questions. A systematic literature review
was conducted to update the evidence since the EULAR publication. After reaching a consensus
agreement, two rounds of voting and group discussion were conducted to generate consolidated recommendations/
statements.

Results:
A significant number of patients in Saudi Arabia experience delays in accessing rheumatologists,
highlighting the significance of timely referral to SLE specialists or rheumatologists to
ensure accurate diagnosis and prompt treatment. The primary goal of Glucocorticoid (GC) therapy
in SLE patients is to establish disease control with a minimum dose and duration. Steroid-sparing
agent utilization facilitates steroid-sparing goals. Hydroxychloroquine is recommended for all
SLE patients, though physicians must carefully monitor toxicity and prioritize regular medication
adherence assessment. SLE management during pregnancy starts from preconception time by assessing
disease activity, major organ involvement, hypercoagulability status, and concomitant diseases
that may negatively impact maternal and fetal outcomes. Multidisciplinary care with close
monitoring may optimize both maternal and fetal outcomes. For patients with antiphospholipid
antibodies, low-dose aspirin prophylaxis is recommended. Also, Long-term anticoagulant medications
are fundamental to prevent secondary antiphospholipid syndrome due to high thrombosis recurrence.

Conclusion:
This Saudi National Clinical Practice guidelines for SLE management provide evidence-
based recommendations and guidance for healthcare providers in Saudi Arabia who are managing
patients with SLE. These guidelines will help to standardize healthcare service, improve
provider education, and perhaps lead to better treatment outcomes for SLE patients.
Respiratory Disorders in Rett Syndrome
Authors: Spoto Giulia , Accetta Arianna Santina , Grella Maria , Di Modica Irene , Nicotera Antonio Gennaro 
Published: May 2024

:
Rett Syndrome (RTT) is a rare and severe neurodevelopmental disorder affecting children
in the early stages of infancy and associated with a MECP2 mutation in 95-97% of individuals
with typical RTT. Nearly all of the patients show breathing abnormalities during their lifespan,
both in wake and sleep and respiratory illness represents an important cause of morbidity and mortality
in RTT. Pathogenic mechanisms underlying breath-holding and other breathing abnormalities
in RTT are mainly related to dysautonomia and an alteration in respiratory control at different
levels, including several regions of the central and peripheral nervous system. Pathogenic variants
in the MECP2 gene have been implicated in the dysfunction of respiratory pathways, affecting
chemosensitivity and the response to neurotransmitters. In addition, frequent comorbidities such
as scoliosis, dysphagia, sleep disorders, and epilepsy can further impair the respiratory function in
these patients.
Exploring Iridium's Catalytic Role in Redox Reactions: A Concise Review
Authors: Sahgal Sumita , Yadav Subhadra 
Published: May 2024

:
Transition metals exhibit a remarkable capacity to catalyse redox processes,
playing a crucial role in various natural, biological, and chemical transformations. Among
all the elements in the periodic table, iridium stands out with the broadest range of oxidation
states. With its electronic configuration of 5d76s2, iridium displays a range of oxidation
states, fluctuating from -3 in [Ir (CO)3]3- to +9 in [IrO4]2+. The utilization of iridium
as a catalyst stems from its capability to adopt these variable oxidation states. Notably,
Iridium (III) complexes exhibit significant catalytic activity in both acidic and basic environments,
facilitating a diverse array of organic and inorganic chemical transformations.
The catalytic mechanism adapts according to the specific conditions under which the
catalysts are employed. Iridium's catalytic efficiency is notably enhanced in an acidic environment,
as highlighted in this review, compared to its performance in a basic medium.
Iridium stands as the sole reported catalyst with the capability to harness sunlight and
transform it into chemical energy, offering promising prospects for application in artificial
energy systems. The high surface-to-volume ratio of IrNPs contributes to their excellent
catalytic performance. As research in Nanocatalysis continues to evolve, iridium remains
a key player in shaping the future of sustainable and efficient chemical processes.
Repeated Thoracic Paravertebral Blocking to Alleviate Pain Symptoms in 66-years-old Man with Post-herpetic Neuralgia: A Case Report
Authors: Chalil Muhammad Jalaluddin Assuyuthi , Sinaga Mual Kristian , Ahmad Muhammad Ramli 
Published: May 2024

Introduction
Post-herpetic Neuralgia (PHN) is a neuropathic pain syndrome resulting from the sequelae of Herpes Zoster (HZ).

Case Report
Therefore, this study aimed to report a case of a 66-year-old male who presented with chronic pain characterized by a burning sensation in the right chest region, specifically at the areola level. The patient had been experiencing these symptoms for a year, which progressed to the severe stage over the past few months. To mitigate pain, a Thoracic Paravertebral Block (TPVB) procedure was proposed and conducted 3 times, with a solution containing levobupivacaine 0.25% and dexamethasone 10 mg in 5 ml.

Conclusion
The procedure was replicated three times. After two weeks, the pain had almost subsided, showing less need for further analgesia.
Association of the Type of Public Pension With Mental Health Among South Korean Older Adults: Longitudinal Observational Study
Authors: Kim Seung Hoon , Kim Hyunkyu , Jeong Sung Hoon , Park Eun-Cheol 
Published: May 2024

Background
As income and health are closely related, retirement is considered undesirable for health. Many studies have shown the association between pension and health, but no research has considered the association between contribution-based public pensions or their types and health.

Objective
This study investigates the association between the type of contributory public pension and depressive symptoms among older adults.

Methods
We analyzed the data of 4541 older adults who participated in the South Korea Welfare Panel Study (2014-2020). Depressive symptoms were measured using the 11-item Center for Epidemiologic Studies Depression scale. Public pensions in South Korea are classified into specific corporate pensions and national pensions. For subgroup analyses, pensioners were categorized according to the amount of pension received and the proportion of public pension over gross income. Analyses using generalized estimating equations were conducted for longitudinal data.

Results
Individuals receiving public pension, regardless of the pension type, demonstrated significantly decreased depressive symptoms (national pension: β=–.734; P<.001; specific corporate pension: β=–.775; P=.02). For both pension types, the higher the amount of benefits, the lower were the depression scores. However, this association was absent for those who received the smaller amount among the specific corporate pensioners. In low-income households, the decrease in the depressive symptoms based on the amount of public pension benefits was greater (fourth quartile of national pension: β=–1.472; P<.001; second and third quartiles of specific corporate pension: β=–3.646; P<.001).

Conclusions
Our study shows that contributory public pension is significantly associated with lower depressive symptoms, and this association is prominent in low-income households. Thus, contributory public pensions may be good income sources for improving the mental health of older adults after retirement.
Mengeksplorasi Praktik Personal Digital Archiving (PDA) dalam Fenomena New Analog Photography di Instagram: Membangun Personal Branding, Pencarian Autentisitas dan Detoksifikasi Digital
Authors: Pamungkas Adhi Wirawan Dwi 
Published: May 2024

This article discusses the phenomenon of the rise of analog photography called new analogphotography on Instagram. Apart from discussing the phenomenon of new analog photography, this article also discusses the practice of personal digital archiving (PDA), which is applied to this phenomenon. Social media is a platform for storing personal digital archives, which has been done by all humans in the internet era and electronic devices have become an integral part of their lives. The method used in writing articles uses a qualitative case study approach. The aim of this article is to find the causes of the new analog photography phenomenon, namely the millennial generation and Gen Z who are very active on social media and have personal branding awareness. The exploration carried out by the millennial generation and Gen Z who have an interest in photography to search for the authenticity of digital presence images and rituals using analog cameras can be categorized as digital detoxification. The limitation of this article is that the number of respondents obtained in quantity is not yet representative. It is hoped that future research will be able to gather more respondents with more varied demographics to be able to map the distribution of this phenomenon. This article explains that photography, which is a form of visual archive, is related to the study of social, cultural and technological topics. So that it provides a new perspective for developing the field of archives, especially special-form archives.
Tantangan Pengarsipan Seni Pertunjukan di Institut Seni Indonesia (ISI) Surakarta
Authors: Jamal Jamal 
Published: May 2024

This research aims to do a theoretical study for recognizing the challenges related to archivingperforming arts at the Indonesian Institute of the Arts (ISI) Surakarta as an integral component of the development of the ISI Surakarta Arts Archive. Employing qualitative research methods with a literature review approach, it gathered information from various sources such as books, academic journals, and previous research. Data analysis is carried out by describing and interpreting the diverse viewpoints and procedural aspects. This research uncovers a fundamental challenge in archiving performing arts at ISI Surakarta due to their ephemeral nature—these arts exist solely during live performances, making preservation a complex task. Tracking the existence of performing arts relies on annotations, recordings, and documents that serve as historical records of these live events. The annotations, recordings, and documentsare derived from the artist's creative process, performance management, audience feedback, artcritics, and public reception. The results of the research state that the challenges faced in archiving performing arts at ISI Surakarta include (1) the need to enhance archivists' understanding of the genesis of performing arts to trace and compile performance-relatedannotations/recordings effectively; (2) the importance of cultivating archival literacy among artists to grasp better and acknowledge the significance of documenting the creative process of their artistic works throughout production and post-performance phases; and (3) the necessity of developing an interactive digital archive for performing arts to draw the artists, the public, and users an access right to contribute authentic and pertinent records, documents, and documentation associated with specific performing arts.