bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterisation of an outbreak of acute liver injury after ingestion of plant‐based food supplement
Authors: Choi Gina , Ahmad Jawad , Navarro Victor , Thung Swan , Khan Ikhlas , Avula Bharathi , Barnhart Huiman , Stolz Andrew ,   the Drug‐Induced Liver Injury Network
Published: June 2024

SummaryBackgroundIn April 2022, French Lentil and Leek Crumble (FLLC), a new frozen food preparation manufactured by Daily Harvest™ (containing Tara flour) was offered as a natural high‐protein meal product. Soon thereafter, widespread anecdotal reports of acute gastrointestinal symptoms with liver injury were reported, leading to its voluntary withdrawal in June 2022, after shipment of 28,000 preparations.AimsTo summarise the clinical and laboratory features of 17 patients with FLLC associated liver injury from the Drug Induced Liver Injury Network (DILIN).MethodsPatients with FLLC‐associated liver injury were enrolled into a prospective protocol and followed for 6 months. Cases were adjudicated by expert opinion causality assessment with summary statistics for data analysis.ResultsEnrolled subjects had a mean age of 41 years, 82% were female with mean BMI of 24 kg/m2. All were Caucasian without underlying liver disease. In most cases, abdominal pain and nausea arose within hours of FLLC ingestion. Mean days from ingestion to identification of liver injury was 3.1 days (±2.8). On enrolment, 53% had jaundice, 47% nausea, 24% fever, 59% abdominal pain, 41% itching and 12% rash. The mean initial serum ALT was 475 U/L (±302), AST 315 U/L (±315), alkaline phosphatase 190 U/L (±76), with a total bilirubin of 2.6 mg/dL (±2). In this study, 63% presented with a hepatocellular pattern of liver injury, 6% cholestatic and 31% mixed as determined by the R value. In addition, 24% of patients were hospitalised, and there were no fatalities or liver transplants. Liver biopsy in one subject revealed acute hepatitis with mild ductular reaction, mild lymphocytic and eosinophilic portal inflammation, mild lobular inflammation, preserved bile ducts and absence of interface hepatitis, steatosis, granulomatous reaction or cholestasis. Phylogenetic analysis confirmed the presence of Tara spinosa, the source of Tara flour.ConclusionsNatural food products are increasingly ubiquitous and may unexpectedly cause significant illness. All clinicians should inquire whether patients are consuming natural food products or herbal supplements and consider them as a potential cause of liver injury.
Migrating sands: Refocusing transboundary flows from water to sediment
Authors: Hackney C. R. 
Published: June 2024

AbstractOver 55,000 km of the world’s interior political border is formed along river channels. Yet it is more than just water that is conveyed downstream and across these borders by river systems, with sediment, pollutants, nutrients also transported, impacting downstream ecosystem service provision and livelihoods. Fundamentally, water and sediment operate in two distinct cycles, the behaviours of which have major implications for their management. The water cycle is inherently circular, with water being replenished by climatic processes across the basin. The sediment system, however, is linear, where once sediment is hindered or removed from the system, it cannot be reintroduced without anthropogenic action. In this paper, the balance between discourses of water and sediment are redressed by viewing the dialogues around transboundary management practices from these two cycles. Using the Mekong River, Southeast Asia as a focus, it is concluded that despite a political discourse that may predominantly focus on water, the management of waterways that traverse or cross international political borders must recognise that flows of water and sediment are intrinsically linked. The flow of rivers across political borders presents both challenges (potentially hindering data generation and sharing) and opportunities for international cooperation on environmental issues. It is argued that the framework for international cooperation on water is a good place to start when trying to address sediment issues, but a recognition of the differing behaviours of water and sediment systems is necessary to ensure appropriate and sustainable management of the sediment resource.
Change in vaping, smoking and dual‐use identities predicts quit success and cigarette usage: A prospective study of people quitting smoking with electronic cigarette support
Authors: Frings D. , Albery I. P. , Kimber C. , Naughton F. , Sideropoulos V. , Dawkins L. 
Published: June 2024

AbstractObjectiveElectronic cigarettes (ECs) are an efficacious support for some but not all people wishing to stop using tobacco. While advice and practical support have been identified as increasing quit success, little research has explored the role of changes in smoking and EC‐related social identities.MethodsA prospective study following 573 people attempting to quit smoking with EC support. Self‐report measures of identification with being a smoker, non‐smoker, vaper and dual user (people using ECs and tobacco products) were taken prior to the quit attempt and at a 12‐week follow‐up.ResultsBaseline identifications with being a smoker, non‐smoker or dual user were not associated with smoking outcomes. Baseline vaper identity baseline was linked to more frequent tobacco abstinence at follow‐up and lower levels of cigarette smoking. Levels of social identification at follow‐up were consistently linked with outcomes, with vaper identity and non‐smoking identities being protective and dual user identity being related to lower abstinence rates but decreased tobacco usage. Changes in identity over time were the most consistent predictor of outcomes.ConclusionsFindings have implications for smoking cessation practice, informing how and when identity‐based interventions may be effective and our understanding of how identity transitions occur.
Sedimentation tempo in an Early Jurassic erg system: Refined chronostratigraphy and provenance of the Clarens Formation of southern Africa
Authors: Head Howard V. , Bordy Emese M. , Bolhar Robert 
Published: June 2024

AbstractThe Clarens Formation is a widespread aeolianite deposited over southern Gondwana and represents the final phase of erg evolution in the main Karoo Basin during the Early Jurassic. Previous age assessments of the formation hinge on limited detrital zircon data, supplemented by relative ages from the biostratigraphy and geochronology of the adjacent Karoo units. This study refines the depositional history of the Clarens Formation, including its sediment source dynamics as well as basin‐wide geochronological framework, based on U–Pb dating of detrital zircon grains, together with petrographic and sedimentological characterization. The abundant presence of heavy minerals like zircon, tourmaline and rutile suggests large‐scale detritus recycling, while the uniform sandstone composition on a regional scale is an indication of sediment homogenisation across the basin. Based on the prominent detrital zircon age fractions, the sediments are interpreted as having been reworked from pre‐existing rocks of the Karoo Supergroup (Permian), the Damara and Saldania Orogenic belts (650–490 Ma), whereas minor sources can be assigned to the Namaqua‐Natal Mobile Belt (1.35–1.1 Ga) and the western Sierras Pampeanas (1.30–1.33 Ga). Unstable minerals (hornblende, garnet, titanite, feldspar) provide evidence for a nearby granitic source east and southeast of the basin, related to likely Grenvillian rocks (1.0–1.3 Ga). An Early Jurassic zircon age fraction is linked to volcanic activity in the Chon Aike Magmatic Province that, at the time, was situated south and southwest of the study area. Maximum depositional ages derived from these detrital zircon dates suggest that the sedimentation of the Clarens Formation spanned an interval of ~10 Ma during the Pliensbachian and early Toarcian. More specifically, the lower part of the formation is of early Pliensbachian age or younger (~191–192), while the upper part is of early Toarcian age or younger (~181–183 Ma). These age patterns are particularly prominent in the south of the basin that was situated closer to the volcanic source.
Pricing the priceless childcare: Early childhood education for babies and toddlers
Authors: Bandelj Nina , Spiegel Michelle 
Published: June 2024

AbstractThis article connects Viviana Zelizer's theory of the social meaning of money to family studies, using the case of American parents’ spending on children. We investigate how money spent on the youngest children—babies and toddlers—reflects the growing expert emphasis on the importance of parental investment in the critical early period for child development. First, we review literature on expert knowledge to trace the shift in increasing emphasis on the importance of building children's cognitive skills through formal education beginning in infancy, offered in center‐based care, moving from spaces of “childcare” to “early childhood education” centers. Second, we use quantitative data from the Consumer Expenditure Survey (1995–2017) to show that parents have increasingly spent money, and an increasing share of their income, on center‐based care for babies and toddlers but not on other child items. Additionally, lower income families have been spending a greater share of their income on center‐based care for their infants than other families. We interpret our findings using Zelizer's theory about the cultural influences on the meaning of money, showing how these can be expert‐led and persist even when families are faced with structural economic constraints.
Effects of dental insurance and dental care utilization on oral health‐related daily life activities among federally qualified healthcare center patients in the United States
Authors: Chandel Tejasvita , Aldosari Muath , Chamut Steffany 
Published: June 2024

AbstractObjectivesTo assess the association between dental insurance, dental care utilization and oral health‐related impact on daily activities among patients visiting Health Resources and Services Administration (HRSA)‐funded health centers in the United States.MethodsThis cross‐sectional study examined the 2014 Health Center Patient Survey (HCPS), a survey of patients who received care at US health centers. Logistic regression analyses were conducted to explore the likelihood of the oral health‐related impact on daily activities domains such as school/work performance, sleeping, eating/chewing, social and home activities considering sociodemographic, dental insurance, and dental care utilization.ResultsAmong 7002 total participants, 6890 self‐reported oral health‐related impact on daily activities. Adults aged 18–44 were 2.6 times more likely to report an overall impact on everyday life activities compared to children and adolescents. After adjusting for sociodemographics, Hispanic patients were less likely to report any oral health‐related impacts, while patients visiting rural centres reported higher odds of oral health related impairment. Patients who experienced delays in receiving dental care or were unable to access dental care when needed were 4.5 times more likely to encounter difficulties in their daily activities.ConclusionsThis study linked limited dental insurance and care to increased oral health issues impacting daily life, particularly among adults, rural populations, and those facing delay in dental care. This highlights the need for policy reforms and interventions aimed at improving dental care access to mitigate the detrimental effects of poor oral health on daily functions for vulnerable populations.
Start, switch and stop (triple‐S) criteria for enzyme replacement therapy of late‐onset Pompe disease: European Pompe Consortium recommendation update 2024
Authors: Schoser Benedikt , van der Beek Nadine A. M. E. , Broomfield Alexander , Brusse Esther , Diaz‐Manera Jordi , Hahn Andreas , Hundsberger Thomas , Kornblum Cornelia , Kruijshaar Michelle , Laforet Pascal , Mengel Eugen , Mongini Tiziana , Orlikowski David , Parenti Giancarlo , Pijnappel W. W. M. Pim , Roberts Mark , Scherer Thomas , Toscano Antonio , Vissing John , van den Hout Johanna M. P. , van Doorn Pieter A. , Wenninger Stephan , van der Ploeg Ans T. 
Published: June 2024

AbstractBackground and purposeTwo novel enzyme replacement therapies (ERTs), studied in phase 3 trials in late‐onset Pompe patients, reached marketing authorization by the European Medicines Agency in 2022 and 2023. The European Pompe Consortium (EPOC) updates and extends the scope of the 2017 recommendations for starting, switching and stopping ERT.MethodsThe European Pompe Consortium consists of 25 neuromuscular and metabolic experts from eight European countries. This update was performed after an in‐person meeting, three rounds of discussion and voting to provide a consensus recommendation.ResultsThe patient should be symptomatic, that is, should have skeletal muscle weakness or respiratory muscle involvement. Muscle magnetic resonance imaging findings showing substantial fat replacement can support the decision to start in a patient‐by‐patient scenario. Limited evidence supports switching ERT if there is no indication that skeletal muscle and/or respiratory function have stabilized or improved during standard ERT of 12 months or after severe infusion‐associated reactions. Switching of ERT should be discussed on a patient‐by‐patient shared‐decision basis. If there are severe, unmanageable infusion‐associated reactions and no stabilization in skeletal muscle function during the first 2 years after starting or switching treatment, stopping ERT should be considered. After stopping ERT for inefficacy, restarting ERT can be considered. Six‐monthly European Pompe Consortium muscle function assessments are recommended.ConclusionsThe triple‐S criteria on ERT start, switch and stop include muscle magnetic resonance imaging as a supportive finding and the potential option of home infusion therapy. Six‐monthly long‐term monitoring of muscle function is highly recommended to cover insights into the patient's trajectory under ERT.
Helicobacter pyloriCagA Promotes the Formation of Gallstones by Increasing the Permeability of Gallbladder Epithelial Cells
Authors: Yu Jingjing , He Yuanhang , Yao Wenchao , Liu Tianming , Liu Xuxu , Zheng Yi , Hao Chenjun , Xue Dongbo 
Published: June 2024

ABSTRACTBackgroundThe formation of gallstones is often accompanied by chronic inflammation, and the mechanisms underlying inflammation and stone formation are not fully understood. Our aim is to utilize single‐cell transcriptomics, bulk transcriptomics, and microbiome data to explore key pathogenic bacteria that may contribute to chronic inflammation and gallstone formation, as well as their associated mechanisms.MethodsscRNA‐seq data from a gallstone mouse model were extracted from the Gene Expression Omnibus (GEO) database and analyzed using the FindCluster() package for cell clustering analysis. Bulk transcriptomics data from patients with gallstone were also extracted from the GEO database, and intergroup functional differences were assessed using GO and KEGG enrichment analysis. Additionally, 16S rRNA sequencing was performed on gallbladder mucosal samples from asymptomatic patients with gallstone (n = 6) and liver transplant donor gallbladder mucosal samples (n = 6) to identify key bacteria associated with stone formation and chronic inflammation. Animal models were constructed to investigate the mechanisms by which these key pathogenic bacterial genera promote gallstone formation.ResultsAnalysis of scRNA‐seq data from the gallstone mouse model (GSE179524) revealed seven distinct cell clusters, with a significant increase in neutrophil numbers in the gallstone group. Analysis of bulk transcriptomics data from patients with gallstone (GSE202479) identified chronic inflammation in the gallbladder, potentially associated with dysbiosis of the gallbladder microbiota. 16S rRNA sequencing identified Helicobacter pylori as a key bacterium associated with gallbladder chronic inflammation and stone formation.ConclusionsDysbiosis of the gallbladder mucosal microbiota is implicated in gallstone disease and leads to chronic inflammation. This study identified H. pylori as a potential key mucosal resident bacterium contributing to gallstone formation and discovered its key pathogenic factor CagA, which causes damage to the gallbladder mucosal barrier. These findings provide important clues for the prevention and treatment of gallstones.
Recent advances in hepatitis E virus research and the Japanese clinical practice guidelines for hepatitis E virus infection
Authors: Kanda Tatsuo , Li Tian‐Cheng , Takahashi Masaharu , Nagashima Shigeo , Primadharsini Putu Prathiwi , Kunita Satoshi , Sasaki‐Tanaka Reina , Inoue Jun , Tsuchiya Atsunori , Nakamoto Shingo , Abe Ryuzo , Fujiwara Keiichi , Yokosuka Osamu , Suzuki Ryosuke , Ishii Koji , Yotsuyanagi Hiroshi , Okamoto Hiroaki ,   The AMED HAV and HEV Study Group
Published: June 2024

AbstractAcute hepatitis E was considered rare until reports emerged affirming the existence of hepatitis E virus (HEV) genotypes 3 and 4 infections in Japan in the early 2000s. Extensive studies by Japanese researchers have highlighted the pivotal role of pigs and wild animals, such as wild boars and deer, as reservoirs for HEV, linking them to zoonotic infections in Japan. Currently, when hepatitis occurs subsequent to the consumption of undercooked or grilled pork, wild boar meat, or offal (including pig liver and intestines), HEV infection should be considered. Following the approval of anti‐HEV immunoglobulin A antibody as a diagnostic tool for hepatitis E by Japan's Health Insurance System in 2011, the annual number of diagnosed cases of HEV infection has surged. Notably, the occurrence of post‐transfusion hepatitis E promoted nationwide screening of blood products for HEV using nucleic acid amplification tests since 2020. Furthermore, chronic hepatitis E has been observed in immunosuppressed individuals. Considering the significance of hepatitis E, heightened preventive measures are essential. The Japan Agency for Medical Research and Development Hepatitis A and E viruses (HAV and HEV) Study Group, which includes special virologists and hepatologists, held a virtual meeting on February 17, 2024. Discussions encompassed pathogenesis, transmission routes, diagnosis, complications, severity factors, and ongoing and prospective vaccination or treatments for hepatitis E. Rigorous assessment of referenced studies culminated in the formulation of recommendations, which are detailed within this review. This comprehensive review presents recent advancements in HEV research and Japanese clinical practice guidelines for HEV infection.
Perceptions and drivers of the metaverse adoption: A mixed‐methods study
Authors: Adhini Nandini Venkatesh , Prasad Ch. V. V. S. N. V. 
Published: June 2024

AbstractMetaverse has garnered considerable attention in recent times. Given its swift pace of development, it is imperative to study the adoption of the metaverse. This study analyses the perceptions and drivers influencing the behavioural intention to use the metaverse among Generation Z and millennials by employing a sequential mixed‐methods approach. In the first stage of the study, in‐depth expert interviews were conducted (n = 20), and the subsequent stage featured a countrywide survey (n = 1253). The outcomes of this study indicate that perceived usefulness, personal innovativeness, perceived enjoyment, facilitating conditions, telepresence, social presence, trust, and regulatory support influence attitudes and behavioural intentions towards the metaverse. The findings also reveal a significant difference in the strength of a few relationships across age, gender, and income levels, shedding light on the crucial factors for organisations seeking to position themselves strategically among various demographic groups. This study significantly contributes to the existing knowledge on emerging optimistic and pessimistic perceptions and factors affecting the adoption of the metaverse. By harnessing these outcomes, organisations can enhance the development and promotion of metaverse experiences.
Cutaneous findings and treatment responses of lipoid proteinosis patients
Authors: An İsa 
Published: June 2024

AbstractObjectivesLipoid proteinosis (LP) is a rare autosomal recessive disorder characterized by the accumulation of hyaline‐like material in the skin, oral mucosa, larynx, and brain. This study aimed to evaluate the dermatological findings and treatment responses of patients diagnosed with LP.MethodsThis retrospective study included 41 patients diagnosed with LP at our clinic between May 2018 and January 2023. The diagnosis of LP was established in 22 patients by detecting mutations in the ECM1 gene. In comparison, in 19 patients, it was based on typical clinical findings and histopathological examination of lesioned skin. Clinical and demographic data such as dermatological findings, treatments received, and responses to treatment were recorded from patient files.ResultsAll patients exhibited skin thickening and acneiform scars. The most commonly observed additional dermatological findings were moniliform blepharosis (60.9%), varioliform scars (29.2%), waxy papules and plaques (24.3%), and blisters with crusts (19.5%). Verrucous lesions, diffuse yellow plaques, and scarring alopecia were observed in adult patients, while hypopigmented lesions and blisters with crusts were seen in the pediatric age group. The most frequently used treatments were acitretin (14.6%) and systemic steroids (9.7%). No improvement in skin lesions was observed in patients treated with acitretin, whereas complete resolution of blisters with crusts was noted in patients treated with systemic steroids.ConclusionsIn addition to the existing literature on dermatological manifestations of LP, hypopigmented lesions and atrophoderma vermiculatum‐like lesions can also be observed in these patients. We believe that short‐term systemic steroid therapy for vesiculobullous lesions can be considered for treatment. We think prospective studies with more patients and requiring long‐term follow‐up are needed regarding the effectiveness of acitretin treatment.
From rapid prototyping to rapid firing: on the feasibility of high‐speed production for complex BaTiO3 components
Authors: Bhandari Subhadip , Hanzel Ondrej , Veteška Peter , Janek Marián , De Bona Emanuele , Sglavo Vincenzo M. , Biesuz Mattia , Franchin Giorgia 
Published: June 2024

AbstractDirect ink writing (DIW) is an attractive additive manufacturing (AM) technology because of its simplicity, production speed, and feedstock flexibility; in addition, the use of a limited amount of binder makes the subsequent thermal debinding process easy. Nevertheless, the conventional approach to debind and sinter AMed components remains extremely slow, representing a bottleneck in the manufacturing process. In order to address such limitation, we explored different rapid sintering strategies: ultrafast high‐temperature sintering (UHS), pressureless spark plasma sintering (P‐SPS), and fast firing (FF), for the densification of BaTiO3 components fabricated by DIW, one of the widely used lead‐free piezoceramics. All sintering technologies allow debinding and sintering of crack‐free components in a few minutes instead of several hours. The final density and microstructure are strongly dependent on the sintering atmosphere (inert for UHS and P‐SPS, air for FF) and a maximum relative density of only ≈72% was obtained when firing occurred in an inert environment, irrespective of the sintering technique (UHS and P‐SPS). An undesired phase transition from tetragonal to hexagonal BaTiO3 was also observed upon UHS and ‐PSPS. On the contrary, FF in air yielded a density of about 95% in a few minutes while maintaining the desired tetragonal polymorph. The results provide proof of feasibility for rapid processing of BaTiO3 components obtained by DIW.