bluuebunny/crossref_metadata_2025_split huggingface dataset:
PERANCANGAN DAN IMPLEMENTASI ANIMASI 2D THE SMELL OF SKUNK
Authors: Bernadhed Bernadhed , Ramadhan Ardyansyah 
Published: May 2024

Animasi frame by frame adalah teknik animasi yang disusun dari banyak rangkaian gambar yang berbeda. Pada animasi frame by frame, setiap perubahan gerakan atau bentuk sebuah objek diletakan pada frame secara berurutan. Semakin banyak frame yang digunakan untuk menampung setiap detail gerakan sebuah benda, animasi yang dihasilkan akan semakin halus. Teknik frame by frame mampu memvisualisasikan animasi dengan ekpresif dan pergerakan yang tidak hanya sebatas pada pergerakan linear dari sumbu x dan sumbu y namun bisa berputar dengan sumbu z. Seperti adegan berkelahi, berputar, melompat ataupun adegan action lainnya. Teknologi digital saat ini memungkinkan untuk menerapkan teknik ini dikarenakan dapat mengurangi kesalahan pada proses menggambar frame by frame.
Pada penelitian ini penulis merancang sebuah film animasi 2 Dimensi yang menceritakan tentang seeokor sigung yang dibenci oleh kawanan kelinci karena baunya yang tidak sedap. Hingga suatu ketika ada suatu kejadian dimana justru bau busuk sigung inilah yang mampu menyelamatkan para kelinci dari serangan brutal Beruang raksasa.. Dari konsep cerita tersebut penulis menggunakan konsep animasi 2 Dimensi. Konsep animasi dipilih dikarenakan adegan tersebut bersifat imaginative dan bertema binatang, sehingga agak sulit untuk diceritakan dengan konsep visual konvensional seperti liveshoot. Sedangkan teknik pengerjaan yang digunakan adalah frame by frame, mengingat banyaknya adegan yang membutuhkan ilustrasi gerakan nyata dan dilebih lebihkan.
Opinions regarding equine veterinarian attire and attributes: results of a horse owner survey
Authors: O’Neil Erin K. , Fogle Callie A. , Sheats M. Katie , Love Kim 
Published: May 2024

Abstract

OBJECTIVE
To investigate potential equine clients’ perceptions of equine veterinarians based on attire.

SAMPLE
763 horse owners/lessees.

METHODS
Participants were invited to complete a survey shared mainly via equestrian social media pages between August and October 2022.1–3 Survey participants were shown pictures of a male veterinarian and a female veterinarian in 7 outfits ranging from casual to business attire and were asked to score the veterinarian on 7 traits: easygoing attitude, friendliness, compassion, trustworthiness, professionalism, competence, and cost of services. The survey asked which of the traits were most valued in an equine veterinarian, as well as whether various aspects of appearance including tattoos, piercings, and hair dyed a nonorganic color were acceptable for equine veterinarians.

RESULTS
Of the 2,655 individuals who opened the survey, 763 responses were included. Respondents were predominantly female (743/763 [97.4%]) from rural areas (493/763 [64.6%]). Only 37.1% (283/763) of respondents agreed that what a veterinarian wears influences their confidence in them. The highest-ranked traits in an equine veterinarian were knowledge/competency (mean ± SD, 1.46 ± 0.98), followed by trustworthiness (2.34 ± 1.08) and compassion (3.50 ± 1.20), with coveralls and scrubs being the preferred attire clients associated with these attributes (with the exception of compassion, for which polo shirt/jeans was the preferred attire). T-shirt/jeans was consistently ranked lowest by respondents in association with these attributes, except in the area of compassion, where polo shirt/black pants was ranked lowest.

CLINICAL RELEVANCE
Our findings suggested the attire and appearance of equine veterinarians can impact client perceptions, with veterinarians wearing scrubs and coveralls associated with higher competency and trustworthiness.
Neck pain but not neurologic disease occurs more frequently in horses with transposition of the ventral lamina from C6 to C7
Authors: Henderson C. S. , Story M. R. , Nout-Lomas Y. S. 
Published: May 2024

Abstract

OBJECTIVE
To determine reasons for horses to have neck radiographs performed, the incidence of transposition of the ventral lamina of C6 onto C7 (TC67), and the final diagnoses for all horses. Our hypotheses were to find a similar incidence of TC67, as has been previously reported, and an increased incidence of neck pain and dysfunction in horses with TC67.

ANIMALS
135 horses.

METHODS
Retrospective observational study. Medical records of 135 horses with cervical vertebral column radiographs between 2020 and 2022 were assessed. Patient signalment, reasons for radiographs, radiographic findings, and diagnoses were analyzed. The Shapiro-Wilk test was used for normality determination. Nonparametric tests were used to analyze data.

RESULTS
20% of horses were diagnosed with TC67. Significantly more horses with TC67 were warmblood horses (63%); TC67 was found in 28% of warmblood horses. There was no significant difference in signalment or whether horses were in work between the groups, although significantly more horses with TC67 performed in English disciplines (71%). No differences in reasons for examination or final diagnoses of neurologic disease, cervical orthopedic disease, or lameness were present between groups. In horses with neck pain, TC67 was significantly more common (31%) than in horses without (18%).

CLINICAL RELEVANCE
Our results indicated that TC67 occurs more in warmblood horses. In the small group of horses with neck pain reported, TC67 was more commonly seen than in those without. Given the complexity of this region and the paucity of studies exploring neck pain and neck biomechanics, we suggest the need for standardized prospective studies.
An imminent need for veterinary medical educators: are we facing a crisis?
Authors: Lairmore Michael D. , Byers Christopher , Eaton Sarah , Sykes Jane E. , Marks Steven , Meurs Kathryn M. 
Published: May 2024

Abstract
A potential emerging shortage of veterinary medical educators requires the profession to acknowledge and understand the factors leading to this outcome. Expanding class sizes within existing schools and colleges of veterinary medicine and the expected expansion of new programs seeking AVMA–Council of Education accreditation have heightened the need to address an impending shortage of veterinary medical educators. A solution-oriented approach that accurately projects educator workforce needs and identifies factors contributing to the shortage requires effective collaboration across various partnering organizations to develop innovations in pedagogy and educational delivery methods. The veterinary profession must also identify and reduce disincentives that deter students and post-DVM trainees from pursuing careers in education. Finally, efforts at the state and federal level are critical to advocate for financial support and incentives for expansion of the veterinary medical educator workforce. Through these collective approaches and partnerships, the veterinary medical educator workforce can be strengthened to overcome obstacles for educating the next generation of veterinarians to meet societal needs.
George F. Kennan and Hungary: A Cold War Visionary and a “remarkable people with rich civilizational qualities”
Authors: Peterecz Zoltán 
Published: May 2024

Abstract
Although George F. Kennan hardly needs an introduction, this article revisits his career. He was the “father” of the containment doctrine, even if he did not accept that title because he believed the successive American governments debauched his murky idea about how to oppose the Soviet Union. Many things are known about Kennan—both his professional and private life—but some small additions are still missing. This essay investigates his relations with, and ideas about Hungary, which so far have earned passing mentions at best. This is not surprising because Hungary rarely became a central issue during the Cold War—with 1956 as an obvious exception—so scholars focused mainly on Kennan, the Russian expert and cold warrior. Still, occasionally Hungary received Kennan’s attention throughout his long career: he made observations and took notes on Hungary, Hungarian foreign policy, and Hungarians as early as the eve of World War II, and he continued to do so as late as Hungary’s joining NATO at the end of the 1990s. These were sometimes indirect assumptions, long-distance observations, or the results of on-site experience. It is interesting to see how the famously realist Kennan approached Hungary and the Hungarian questions throughout more than half a century. His relationship with either Hungary or Hungarians, however, has never been within the scope of an academic study, so this article serves as the basis for possible future endeavors into that direction. By introducing Kennan’s episodic views and impressions regarding Hungary in the larger part of the twentieth century, the article fills a small but important gap in the growing field of the history of American–Hungarian relations and adds to the portrait of Kennan. (ZP)
New Fixed Point Theorems on Complete b-Metric Space by Using Rus Contraction Mapping
Authors: Bhattacharjee Krishna , Laha Amit Kumar , Das Rakhal 
Published: May 2024

Abstract
This paper investigates a fixed point over a complete b-metric space for a family of contractive mappings. In this paper, we have discovered new results in the direction of the complete b-metric space by using Rus contraction. Furthermore, we establish a common fixed point theorem between two mappings over complete b-metric space. We also provide some non-trivial examples to display the authenticity of our established results.
A new approach in the development of a dental caries vaccine
Authors: Rubnikovich S. P. , Poboinev V. V. , Khrustalev V. V. 
Published: May 2024

The genomes of the bacteria Streptococcus mutans and Streptococcus sobrinus, which cause dental caries, currently have been fully sequenced. However, the secondary and tertiary structures of the full-size surface proteins of these microorganisms, by which they attach to the surface of teeth covered with saliva, have not been instrumentally determined at the moment. There are a number of experimental studies on the use of these proteins in the process of developing a dental caries vaccine. However, there is currently no commercially available dental caries vaccine.The aim of the study was to choose an antigen for subsequent molecular modeling of a unique peptide for the development of a dental caries vaccine.To develop an effective and safe dental caries vaccine, it is necessary to perform a number of experiments in silico, preceding experiments in vitro and in vivo. Today, this approach is not only generally recognized, but also allows to significantly reduce the cost of experiments and time at the preclinical and clinical studies. According to our hypothesis, as an antigen for the development of a dental caries vaccine, it is necessary to use a short fragment of the surface protein (a peptide) of Streptococcus mutans and/or Streptococcus sobrinus, whose homology in amino acid sequence is 84.8 %, the spatial structure of which should correspond to the spatial structure of the corresponding fragment in a full-sized protein. In addition, the selected protein fragment, which will be part of the vaccine peptide, must be available to antibodies, i. e. located on the surface of the protein and defined as a B-cell linear and spatial epitope. Also, according to our hypothesis, the vaccine peptide may consist of the most stable fragments of alanine and proline rich regions of the surface protein of Streptococcus mutans and/or Streptococcus sobrinus for mutual stabilization of the spatial structure.
Frequency of CYP2C19, P2RY12, ITGB3, ITGA2, and eNOS3 gene polymorphism in patients with myocardial infarction
Authors: Pronko Т. Р. , Snezhitskiy V. А. , Stsiapura Т. L. , Gorchakova О. V. 
Published: May 2024

The aim of the study was to assess the distribution of polymorphic variants G681A (*2) of the CYP2C19 gene, H1/H2 of the P2RY12 gene, T1565C of the ITGB3 gene, C807T of the ITGA2 gene, and T786C of the eNOS3 gene in the population of the Grodno region, and to study their associations with myocardial infarction (MI). The study of the population consists of 493 people, including 400 patients with MI aged 31 to 74 years and 93 people of the control group aged 32 to 60 years. Research data (clinical and genotyping performed by polymerase chain reaction) were analyzed using STATISTICA 10.0 software. The prevalence of carriage of genotypes associated with high residual platelet reactivity and variability in response to dual antiplatelet therapy among patients with MI was 25.2 % for the G681A polymorphic locus of the CYP2C19 gene (GA + AA), and for the H1/H2 polymorphic locus of the P2RY12 gene (H1/H2 + H2/H2) – 40.0 %, for the C807T polymorphic locus of the ITGA2 gene (CT + TT) – 65.8, for the T1565C polymorphic locus of the ITGB3 gene (TC + CC) – 25.5, for the polymorphic locus T786C of the eNOS gene (TC + CC) – 69.2 %. Among the individuals of the control group, the frequency of occurrence of these genotypes was 18.3, 46.2, 60.2, 37.6, 48.4 %, respectively. In patients with MI, compared to the control group, the TT genotype of the eNOS gene was less common (χ2 = 13.6, p = 0.0002), the CC genotype of the eNOS gene (χ2 = 5.4, p = 0.02) and the allele 786C of the eNOS gene (χ2 = 15.1, p = 0.0001) were more often detected. The carriage of the 786C allele of the eNOS gene increased the risk of MI in the studied population (OR = 2.0, 95 % CI: 1.41‒2.82, p = 0.0001). Gender differences were not found in the distribution of genotypes and alleles within the studied groups. There were no differences in carriage by the number of combinations of minor alleles between the control group and patients with MI. The most common combinations of minor alleles in both groups were comparable.
Mechanical properties of breast cancer cells of different molecular biological subtypes in reaction with antibodies against CD109 antigen
Authors: Shkliarava N. М. , Chelnokova I. А. , Nadyrov Е. А. , Krylov А. Yu. , Starodubtseva М. N. 
Published: May 2024

The cytoskeleton is a participant in key cell events in oncogenesis and the reaction of cancer cells to therapeutic factors. The state and structure of the actin cytoskeleton contributes significantly to the mechanical behavior of cancer cells, forming the main features of their mechanical phenotype.In the work, using atomic-force microscopy and fluorescent microscopy, we studied the changes in the structure of the actin cytoskeleton and parameters of the mechanical properties of breast cancer cells of different molecular biological subtypes (hormone-sensitive, line ZR-75, and triple-negative, BT-20 line, subtypes) when cells interact with the CD109 antigen, a TGF-β signaling pathway inhibitor. The use of antibodies for immobilizing the CD109 antigen has been shown to cause significant changes in the spatial organization of the actin cytoskeleton, stiffness and adhesive properties of the cell surface of both cell lines. Because of differences in the structure of the actin cytoskeleton, changes in the mechanical properties of the cells of different molecular biological breast cancer subtypes and the implementation of the TGF-β signaling pathway in these cells when binding to antibodies against the CD109 antigen occur in different ways. The obtained data open new perspectives for the development and evaluation of the effectiveness of anticancer drugs.
Pengembangan Ekonomi Kreatif Hasil Pertanian Dan Manajemen Bisnis Kecil Menengah Di Era Digital Di Desa Mekar Sari Sekotong
Authors: Bayu wijaya I gede , Suli Asmara Yanti Ni Nyoman , Sukendri Nengah , Kade Suparta Ida , Nyoman Sutrian Ida Ayu , Rani Putri Mahendri Ni Ketut 
Published: May 2024

Perubahan orientasi ekonomi global ini, yang menekankan pentingnya aset sumber daya manusia, menghasilkan persaingan yang ketat dalam ranah kreativitas (kompetisi bakat global). Peningkatan kapasitas desa dapat meningkatkan kemandirian masyarakat pedesaan dengan mempromosikan potensi yang luar biasa, memperkuat institusi, dan memberdayakan masyarakat. Peningkatan daerah pedesaan melalui industrialisasi pertanian atau peningkatan produksi pangan bergantung pada kemajuan lokal dan ekspansi ekonomi. Terletak di dusun Nusa Sari, Desa Mekar Sari, dicirikan oleh ekonomi berbasis pertanian dan perkebunan, yang dapat menjadi sumber daya dalam membangun industri kreatif Usaha Mikro dan Kecil. Tujuan dari pengabdian kepada Masyarakat ini adalah memberikan pemahaman dan pelatihan tentang pemanfaatan sumber daya dari hasil pertanian dan perkebunan sehingga menjadi industry kreatif yang dapat dijalankan oleh Masyarakat pada lokasi pengabdian.
Metode yang digunakan pada pengabdian kepada Masyarakat yang pertama adalah dengan melakukan observasi sasaran yang dituju untuk diberikan pelatihan pengembangan industry kreatif. Selanjutnya, sumber daya pelatihan yang diberikan kepada masyarakat, meliputi identifikasi prospek ekonomi dalam masyarakat, menanamkan dorongan kewirausahaan, dan mengawasi administrasi keuangan bergulir. Ini diikuti dengan eksplorasi semua aset yang layak dalam masyarakat yang dapat berfungsi sebagai dasar untuk kegiatan bisnis.
Hasil dari pengabdian kepada masyarakat menunjukkan bahwa dusun Nusa Sari, memiliki potensi yang besar untuk dimanfaatkan sebagai sumber daya yang dikelola oleh masyarakat yang menjanjikan untuk perdagangan dan memperoleh bahan-bahan yang diperlukan. Tingkat pendidikan para ibu dan remaja di Dusun Nusa Sari mempengaruhi kemampuan mereka untuk maju dan berkembang. Kurangnya modal ventura di antara mitra menghambat motivasi mereka untuk meningkatkan situasi ekonomi mereka. Meskipun demikian, mitra menunjukkan dedikasi yang kuat untuk secara efektif mengelola dana bergulir yang disediakan oleh tim proyek, yang bertujuan untuk mendukung modal kerja mereka
Histodiagnosis of heterakidosis in chickens
Authors: Stafford V. V. 
Published: May 2024

The purpose of the research is to study pathology findings in heterakidosis in broilers.Materials and methods. The study used pathological material (cecum, liver) from 8 laying hens aged one year. Organ samples were delivered to the Pathology Sector in 10% buffered formalin. They were fixed for 36 hours and examined histologically using paraffin embedding. Semi-automatic Thermo Scientific equipment was used to process tissue samples. Histologic specimens were stained with hematoxylin and eosin. The specimen histoarchitecture was assessed with an Axio A1.0 microscope; photographs were taken using the AxioVision software.Results and discussion. Visual assessment of the pathological material revealed thickening of the distal cecum while the liver samples had no signs of pathology. It was found that Heterakis spp. was about 1 cm long; helminth eggs were oval-shaped and had a strong, uniform shell; their size was 49 × 26 micrometers in the mean. When dwelling in the cecum, Heterakis spp. causes atony of the distal cecum wall, and development of inflammatory and necrotic processes in the intestinal mucosa, which promotes active growth of bacterial flora, accumulation of bacterial byproducts and intoxication. In places where the helminth is localized, eggs accumulate and a risk of Histomonas spp. infection increases, namely, amoebic (in the intestinal lumen) and spherical (in the intestinal mucosa) forms of the protozoan were identified. It was not possible to differentiate Histomonas spp. in assessing the histological specimens of the liver from the infected birds. In diagnostics, we should consider the great similarity of morphological characteristics of Heterakis spp. and Ascaridia spp. eggs.
The efficacy of antiparasitic drug based on Lufenuron, Moxidectin, and Praziquantel against ixodidosis in dogs
Authors: Tsepilova I. I. , Shemyakova S. A. , Bolatchiev K. Kh. 
Published: May 2024

The purpose of the research is to study the efficacy of antiparasitic drug based on Lufenuron, Moxidectin, Praziquantel against ixodidosis in dogs under natural conditions and during experimental infection with ixodid ticks.Materials and methods. The experiments used the drug in tablet formulation containing Lufenuron in 320 mg, Moxidectin in 9.6 mg and Praziquantel in 160 mg. To study the preventive and therapeutic acaricidal effect of the drug against ixodid ticks in the country part of the Karachaevsky District of the Karachay-Cherkess Republic, two groups (10 dogs each) were formed of Alabai dogs or outbred dogs with a body weight of 16–76 kg. The dogs of the first experimental group were administered the drug in tablets. The dogs of the second group served as controls and were not treated. The experiment used clinically healthy dogs of both sexes over 6 weeks of age, spontaneously infected with Ixodidae. Animals were selected so that they were not exposed to drugs for at least 1 month prior to the experiment. The animals were kept under normal conditions throughout the experiment and received their usual food. Antiparasitic tablets were administered to the dogs individually, once, orally, mixed with food at a dose of 1 tablet per 16–32 kg of body weight. The ixodid infection was diagnosed in the dogs by clinical examination. The genus of Ixodidae was determined by typical morphological characteristics. The drug efficacy was evaluated based on reduced number or absence of ticks on the treated animals (experimental) versus the untreated animals (control). Before the experiment and after the drug, the animals were examined every hour for 48 hours, and condition, separation, separation time from the start of the drug and death of the ticks were recorded; the dogs were then examined every 5–7 days for two months.Results and discussion. The article presents study data on antiparasitic drug efficacy against ixodidosis in dogs spontaneously infected with Ixodes ricinus, I. persulcatus, and Dermacentor reticulatus. The result of the studies found that the antiparasitic drug (active substances were Lufenuron, Moxidectin, and Praziquantel) had a therapeutic effect that was recorded on day 5 after treatment and was 90%. The preventive efficacy was also above 70%: on day 7 and 14, this value was 90.0 and 86.9%, respectively, which indicated the duration of the preventive effect for 25–28 days. To fully evaluate the acaricidal efficacy against ixodidosis, studies were conducted on experimentally infected animals. Forty percent efficacy was determined at 48 hours after the drug; at 2 weeks after the drug, 90 %, 98.5 and 100 % efficacy were determined against ixodidosis in the dogs at 24 hours, 48 and 72 hours after the transfer of ticks, respectively. At 4 weeks after the drug, 100 % efficacy was determined against ixodidosis in the dogs at 24, 48 and 72 hours after the transfer of ticks, respectively.