bluuebunny/crossref_metadata_2025_split huggingface dataset:
Digitally guided root removal and simultaneous implant placement: A case study
Authors: Gala Roksolana , Al Sammarraie Mohammed , Padilla Rocio Sanchez , Zhou Zheng , Neely Anthony L. , Kinaia Bassam M. 
Published: May 2024

AbstractBackgroundEncountering a retained root tip post‐extraction and prior to implant placement is a possible clinical complication. There are numerous approaches for removing retained roots that may be traumatic or atraumatic. Regardless of the approach, careful treatment planning is important to minimize complications, reduce morbidity, and preserve bony structures. The aim of the current case study is to introduce a technique and digitally generated device used for identifying and atraumatically removing a retained root tip and simultaneously placing a stable dental implant.MethodsA 63‐year‐old female with a history of myocardial infarction, hypertension, and acute pancreatitis presented for implant placement at site #5. Clinical examination revealed adequate interocclusal, mesiodistal, and buccolingual dimensions for implant placement. Radiographic examination using cone beam computed tomography revealed that retained root #5 interfered with implant placement. Digital planning was used to extract the root tip with minimal trauma to maintain adequate bone for simultaneous implant placement with good primary stability.ResultsThe follow‐ups at 1, 3, and 6 weeks and 4, 8, and 10 months revealed good bone preservation with an osseointegrated implant.ConclusionsEmployment of digital planning to create a palatal window allowed excellent accuracy in removing the retained root while maintaining the bony foundation for a well osseointegrated dental implant.Key points
Pre‐planning using cone beam computed tomography scan merged with an intraoral digital scan is necessary for precise location of a retained root and correct implant placement with excellent primary stability.
A digitally planned 3D surgical guide is a useful method for extracting retained roots during implant placement to minimize bone damage.
Digital planning provides a precise and minimally invasive implant surgery.
A specific surgical procedure to remove the apices in the upper jaw
Authors: Saad Issa , Al‐Raeei Marwan , Rikab Mohamad Salem , Al Manadili Ahmad , Azmeh Chadi , Alkhori Tala , Alhaja Remon , Kabani Rama , Albokaii Joudi , Saad Maya 
Published: May 2024

Key Clinical MessageThis clinical case report focuses on a case of surgery performed on a patient with the aim of cutting the dental apices in the patient's upper jaw. Mineral trioxide aggregate (MTA) was used as a filling material, and monitoring the condition showed that the operation was successful.
Synthesis and Performance of Bio‐Based Amphoteric Surfactants
Authors: Jansen Laura M. , den Bakker Pieter C. , Venbrux Niek , van Rijbroek Kim W. M. , Klaassen‐Heshof Dimphna Johanna , Lenferink Wouter B. , Lücker Sebastian , Ranoux Adeline , Raaijmakers Harry W. C. , Boltje Thomas J. 
Published: May 2024

AbstractAs the global surfactant market continues to expand, there is an increasing need to develop bio‐based alternatives in the shift towards a circular economy. This study focuses on the synthesis of polar, amphoteric, amine‐oxide surfactants starting from biomass‐derived monosaccharides and demonstrating their potential in various applications. The synthesis involved a reductive amination of the sugars with an alkylamine and formaldehyde followed by oxidation to produce N‐oxide surfactants. These bio‐based surfactants exhibited promising properties, including high solubility, foamability, surface tension reduction, and critical micelle concentration. In particular, N‐GalA1.10 and N‐GalA1.12 showed comparable performance to commercial surfactants. Furthermore, these bio‐based surfactants demonstrated significantly lower skin irritation potential when compared to petrochemical‐derived counterparts like sodium laureth sulfate (SLES), making them potentially suitable for personal care products. The biodegradability assessment revealed that N‐GalA1.12 exhibited good biodegradation, indicating its potential environmental compatibility. In conclusion, this study highlights the potential of bio‐based N‐oxide surfactants derived from monosaccharides as sustainable and skin‐friendly alternatives to traditional amphoteric surfactants, like cocamidopropyl betaine (CAPB).
A Catalytic Approach for the Synthesis of Peptide−Oligonucleotides Conjugates in Aqueous Solution or On‐Column
Authors: Gras Marion , Adler Pauline , Smietana Michael 
Published: May 2024

AbstractPeptide−oligonucleotide conjugates (POCs) are covalent architectures composed of a DNA or RNA molecules linked to a peptide. These constructs have found widespread applications ranging from hybrid nanomaterials to gene‐targeted therapies. Considering the important role of POCs, a new catalytic approach for their preparation is reported here, that could be applied either on solid support in anhydrous media, or post‐synthetically in aqueous buffer. Single amino acids, peptides and cell penetrating peptides (CPPs) were conjugated to various oligo(ribo)nucleotides with high conversions and good isolated yields. The applicability of the method was demonstrated on more than 35 examples including an analogue of a commercial therapeutic oligonucleotide. Other conjugation partners, such as deoxycholic acid and biotin were also successfully conjugated to oligonucleotides. To highlight the potential of this catalytic approach, these conditions have been applied to iterative processes, which is of high interest for the development of DNA‐Encoded Libraries.
Nanoproteases: Alternatives to Natural Protease for Biotechnological Applications
Authors: Wang Yaru , Guo Mingxiu , Xu Xiaolong 
Published: May 2024

AbstractSome nanomaterials with intrinsic protease‐like activity have the advantages of good stability, biosafety, low price, large‐scale preparation and unique property of nanomaterials, which are promising alternatives for natural proteases in various applications. An especial term, “nanoprotease”, has been coined to stress the intrinsic proteolytic property of these nanomaterials. As a new generation of artificial proteases, they have become a burgeoning field, attracting many researchers to design and synthesize high performance nanoproteases. In this review, we summarize recent progress on all types of nanoproteases with regard of their activity, mechanism and application and introduce a new and effective strategy for engineering high‐performance nanoproteases. In addition, we discuss the challenges and opportunities of nanoprotease research in the future.
Application of machine learning on hydrate formation prediction of pure components with water and inhibitors solution
Authors: Nasir Qazi , Suleman Humbul , Abdul Majeed Wameath S. 
Published: May 2024

AbstractThe present work investigates the use of machine learning approaches for the prediction of hydrate formation pressure (HFP) in gas hydrate systems. Advanced machine learning models, including the decision tree regressor (DTR), random forest regressor (RFR), extreme gradient boosting (XGB), gradient boosting regressor (GBR), histogram gradient boosting regressor (HGBR), and CatBoost regressor (CB), are trained and evaluated on a large dataset consists of 3137 experimental data points. The models are evaluated using R‐squared (R2), mean squared error (MSE), mean absolute error (MAE), and root mean squared error (RMSE). The study indicates that for the intent of HFP prediction, CatBoost outperformed all other machine learning models. It demonstrated high accuracy on the testing set with an R2 value of 0.9922, and with the lowest RMSE (1.61 × 10−3), MAE (7.90 × 10−4), and MSE (2.58 × 10−6), CatBoost strengthened its prediction ability.
Performance and mechanism of DL‐alanine ionic liquid shale inhibitor
Authors: Feng Liu , Bo Wang , Chunshuo Han , Jia Du , Yu Wang , Weiqiang Zhou , Weichao Du , Quande Wang 
Published: May 2024

AbstractShale hydration and expansion during drilling can lead to wellbore instability, sticking, and frequent leakage accidents. To prevent these issues, an ionic liquid (IL) inhibitor solution was synthesized using DL‐alanine and 98% concentrated sulphuric acid as raw materials. The optimum composition and effect of the synthesized inhibitor in oilfield water‐based drilling fluids were evaluated through anti‐expansion, linear expansion rate, water washing resistance, and clay hydration dispersion experiments. The inhibition mechanism was investigated by thermogravimetric analysis, infrared spectroscopy, zeta potential, contact angle, and X‐ray diffraction analysis. The results show that the optimum IL consists of a 1:1 molar ratio of DL‐alanine to concentrated sulphuric acid synthesized under a reaction temperature and time of 70°C and 18 h, respectively. The resulting DL‐alanine IL exhibited the best inhibitory effect on the hydration, dispersion, and expansion of clay at a concentration of 0.5% in aqueous solution, and its linear expansion rate was only 18.49%. After adding a quantitative amount of clay to different concentrations of DL‐alanine IL aqueous solution, the expansion volume of the clay decreased and the water washing resistance significantly improved. These results provide a theoretical basis for improving the safety and efficiency of shale horizontal well drilling operations.
The World Health Organization Reporting System for Pancreaticobiliary Cytopathology: Overview and Summary
Authors: Centeno Barbara A. , Saieg Mauro , Siddiqui Momin T. , Perez‐Machado Miguel , Layfield Lester J. , Weynand Birgit , Reid Michelle D. , Stelow Edward B. , Lozano Maria D. , Fukushima Noriyoshi , Cree Ian A. , Mehrotra Ravi , Schmitt Fernando C. , Field Andrew S. , Pitman Martha B. 
Published: May 2024

AbstractThe recently published WHO Reporting System for Pancreaticobiliary Cytopathology (World Health Organization [WHO] System) is an international approach to the standardized reporting of pancreaticobiliary cytopathology, updating the Papanicolaou Society of Cytopathology System for Reporting Pancreaticobiliary Cytology (PSC System). Significant changes were made to the categorization of benign neoplasms, intraductal neoplasms, mucinous cystic neoplasms, and malignant neoplasms considered low grade. Benign neoplasms, such as serous cystadenoma, categorized as Neoplastic: benign in the PSC system, are categorized as Benign/negative for malignancy in the WHO system. Pancreatic neuroendocrine tumor, solid‐pseudopapillary neoplasm, and gastrointestinal stromal tumor, categorized as Neoplastic: other in the PSC system, are categorized as Malignant in the WHO System in accord with their classification in the 5th edition WHO Classification of Digestive System Tumours (2019). The two new categories of Pancreaticobiliary Neoplasm Low‐risk/grade and Pancreaticobiliary Neoplasm High‐risk/grade are mostly limited to intraductal neoplasms and mucinous cystic neoplasms. Low‐risk/grade lesions are mucinous cysts, with or without low‐grade epithelial atypia. High‐risk/grade lesions contain neoplastic epithelium with high‐grade epithelial atypia. Correlation with clinical, imaging, and ancillary studies remains a key tenet. The sections for each entity are written to highlight key cytopathological features and cytopathological differential diagnoses with the pathologist working in low resource setting in mind. Each section also includes the most pertinent ancillary studies useful for the differential diagnosis. Sample reports are provided for each category. Finally, the book provides a separate section with risk of malignancy and management recommendations for each category to facilitate decision‐making for clinicians.
Infinite‐width limit of deep linear neural networks
Authors: Chizat Lénaïc , Colombo Maria , Fernández‐Real Xavier , Figalli Alessio 
Published: May 2024

AbstractThis paper studies the infinite‐width limit of deep linear neural networks (NNs) initialized with random parameters. We obtain that, when the number of parameters diverges, the training dynamics converge (in a precise sense) to the dynamics obtained from a gradient descent on an infinitely wide deterministic linear NN. Moreover, even if the weights remain random, we get their precise law along the training dynamics, and prove a quantitative convergence result of the linear predictor in terms of the number of parameters. We finally study the continuous‐time limit obtained for infinitely wide linear NNs and show that the linear predictors of the NN converge at an exponential rate to the minimal ‐norm minimizer of the risk.
Developing ensemble clustering through similarity measures: A semi‐supervised hierarchical clustering learning
Authors: Wang Dandan , Li Qi 
Published: May 2024

SummaryA generic variation of hierarchical clustering (HC) that builds clusters from the bottom up is called agglomerative hierarchical clustering (AHC). The extension of AHC techniques using similarity criteria is the main topic of this research. Based on this, we create an AHC method that accomplishes clustering through ensemble approaches and combines the clustering of clusters with an original similarity measure. Three steps make up the proposed method's primary section. The first phase combines several individual AHC techniques to identify links between samples and create preliminary clusters. A heuristic similarity measure based on the developed clusters is used to determine how similar the samples are. The initial clusters produced using various techniques are all re‐clustered to create superclusters in the second step. The third phase involves creating the final clusters by assigning each sample to a supercluster with the greatest similarity after the clusters have been formed. Based on several benchmark datasets from the UCI machine learning repository, extensive experimental research has been done to assess the performance of the suggested approach. The outcomes unequivocally demonstrate that the suggested AHC‐based paradigm outperforms cutting‐edge techniques.
Solvatochromism in Mixtures of Hydrogen Bond Acceptor (HBA) Solvents with Water
Authors: Spange Stefan , Seifert Andreas 
Published: May 2024

AbstractThe UV/Vis absorption energies νmax of Reichardt's dye B30 with respect to ET(30) and 4‐nitroaniline (NA) are investigated as a function of the solvent composition Nav,z. in co‐solvent/water mixtures. Nav,z. is the average molar concentration of the solvent mixture at a given solvent fraction z. The z can be the mole, the volume or the mass fraction. The co‐solvents considered were acetonitrile, acetone, tetrahydrofuran, pyridine, piperidine and 2‐(diethylamino)‐ethanol. Acetone and acetonitrile can be expected to slightly enhance the water structure at low co‐solvent concentrations. This interpretation is supported by the analysis of the refractive index as a function of the solvent composition. In general, it can be stated that the structural complexity of the binary solvent mixtures is mainly responsible for the evolution of the absorption energies ET(30) or νmax(NA) as a function of the mixture composition. In particular, the endothermic solvation of NA in co‐solvent/water mixtures and its effect on the νmax(NA) is highlighted.
Unmet Needs, Minority Stress and Mental Health Outcomes Among Transgender Individuals: The Mediating Role of Schema Domains
Authors: Radford George , Byrne Jamie E. M. , Staiger Petra K. , Karantzas Gery C. 
Published: May 2024

ABSTRACTExposure to gender‐related minority stressors, the negative experiences and beliefs that stem from anti‐trans stigma increases transgender and gender diverse (TGD) people's vulnerability to experiencing poor mental health outcomes. This study examined if the relationships between experiences of minority stress and mental health outcomes were mediated by early maladaptive schemas: mental representations shaping the way people view themselves, others and the world. Drawing from a schema therapy perspective, the study additionally examined if caregivers' failure to meet TGD people's core emotional needs was associated with mental health outcomes and if schemas similarly mediated these relationships. A total of 619 TGD adults completed an online survey about early maladaptive schemas, core emotional needs, gender‐related minority stress and psychological distress and wellbeing. Causal mediation analyses indicated that caregivers who did not meet TGD people's core emotional needs and greater experiences of minority stress were associated with increased distress and lower wellbeing. These relationships were mediated by schema severity, particularly the disconnection and rejection and impaired autonomy domains. These findings provide empirical support for the schema therapy model's assumption that unmet core emotional needs are associated with schema formation. For TGD people, maladaptive beliefs about the self, others and world can form in response to manifestations of anti‐trans stigma within the individual, their interpersonal relationships, community and broader society. Caregivers' failure to meet needs, plus experiences of minority stress throughout the individual's system, leads to greater distress and lower wellbeing; however, clinical interventions targeting schemas may improve outcomes for this at‐risk group.
A Self‐Reported Study on Explanatory Variables of Stress in Multiple Sclerosis Patients: Exploring the Effect of Physical Conditions and Emotion Regulation Processes
Authors: Carvalho Teresa , Sousa‐Mendes Andreia , Benedito Luís , Gomes Carolina , da Motta Carolina 
Published: May 2024

ABSTRACTBackgroundMultiple sclerosis (MS)‐linked stress is frequent, multidetermined and facilitates the onset/exacerbation of MS. However, few explanatory models of stress analysed the joint explanatory effect of emotion regulation and clinical outcomes of MS in those patients.ObjectiveThis study explored whether self‐reported MS‐related conditions (number of relapses, fatigue and global disability) and specific emotion regulation processes (experiential avoidance and self‐compassion) explain stress symptoms in MS patients.MethodsThe MS sample comprised 101 patients with MS diagnosis receiving treatment in hospitals and recruited through the Portuguese MS Society. The no‐MS sample included 134 age‐, sex‐ and years of education‐matched adults without MS recruited from the general Portuguese population. Both samples did not report other neurological disorders. Data were collected using self‐response measures.ResultsAll potential explanatory variables differed significantly between samples, with higher scores found in MS patients. In MS clinical sample, those variables and years of education correlated with stress symptoms and predicted stress symptoms in simple linear regression models. These results allowed their selection as covariates in a multiple linear regression model. Years of education, the number of relapses, fatigue and experiential avoidance significantly predicted 51% of stress symptoms' total variance.ConclusionsThis study provides preliminary evidence on the importance of clinicians and researchers considering the simultaneous contribution of years of education, the number of perceived relapses, fatigue and experiential avoidance as factors that can increase vulnerability to stress in MS patients. Psychological intervention programmes that tackle these factors and associated stress symptomatology should be implemented.
Potassium tert‐Butoxide‐Promoted Aerobic Dehydrazination of Arylhydrazines: From Arylhydrazines to Substituent Aromatics
Authors: Zhang Shengli , Tan Xiangdong , Wu Yingxu , Si Yu , Sun Rensong , Liu Ziang , Nie Yun , Gao Zhigang , Wang Lei 
Published: May 2024

AbstractAn efficiently aerobic dehydrazination of arylhydrazines promoted by potassium tert‐butoxide (tBuOK) is detailed in this study. This method smoothly produces aromatics analogues from arylhydrazines using catalytic amount of tBuOK under practical conditions, exhibiting excellent functional group tolerance and a broad substrate scope. The application potential of this approach is further demonstrated through the preparation of deuterated, iodinated and brominated aromatics. Moreover, it shows that this aerobic base‐mediated dehydrazination could be utilized to prepare unsymmetrical aryl sulfides, selenides and tellurides with high efficiency.
The social grounds of personal self: Interactions that build a sense of ‘we’ help clarify who ‘I’ am
Authors: Koudenburg Namkje , Jetten Jolanda , Enz Karalyn F. , Haslam S. Alexander 
Published: May 2024

AbstractMany lay people believe that the best way to develop a clear sense of ‘who you are’ is to shut yourself off from others and engage in introspection. Increasingly, however, empirical evidence points to the social aspects of identities and identity development. Building on this, we argue that a strong sense of personal identity is more likely to be derived from meaningful social interaction. More specifically, we argue that when communication allows people to develop a sense of shared identity, it can also promote a sense of personal self. Consistent with this hypothesis, evidence from three experiments indicates that social interaction indirectly enhances people's self‐concept clarity and personal identity strength, through an increased experience of shared identity and social validation. This suggests that a sense of ‘me’ is not formed independently of others but also through the experience of ‘we’ in interaction.
New Phases in the Sc−Mn−Si and Sc−Mn−Al−Si Systems Through Molten Indium Flux Synthesis
Authors: Lefèvre Robin , Eder Felix , von Rohr Fabian O. 
Published: May 2024

AbstractThrough the application of synthesis via molten indium flux, we have been able to expand the ternary Sc−Mn−Si system and the quaternary Sc−Mn−Al−Si system. Specifically, we report on five previously unknown chemical compounds, namely β‐ScMnSi2, Sc4+xMn4Si7–2x, Sc2Mn4Si5, Sc2Mn3Si4, and Sc4Mn2AlSi4. The compounds with the stoichiometries Sc2Mn4Si5, Sc2Mn3Si4, and Sc4Mn2AlSi4 have previously not been reported. We find that these crystallize in the V6Si5, Hf2Ru3Si4, and Ho4Ni2InGe4 structure types, respectively. For the ternary compounds with the stoichiometries of ScMnSi2 and Sc4+xMn4Si7–2x, we find clearly deviating structural solutions compared to earlier reports. β‐ScMnSi2 is found to crystallize in the monoclinic crystal system isostructural to a supercell of the MnTiSi2 structure and clearly deviating from the known orthorhombic α‐polymorph. The compound Sc4+xMn4Si7–2x is structurally very similar to Sc4Mn4Si7, but exhibits the P4/nmm space group instead of I4/mmm, and is related to the Zr4Co4Ge7 structure. Disorder between Si and Sc sites leads to the off‐stoichiometric composition, for which we found x=0.287(5).