bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors associated with transition to a nursing home in older adults living in naturally occurring retirement communities
Authors: Sheth Maya S. , Rochon Paula A. , Altaf Azmina , Boblitz Alexa , Bronskill Susan E. , Brown Kevin A. , Hahn‐Goldberg Shoshana , Huynh Tai , Lewis‐Fung Samantha E. , Feng Patrick , Savage Rachel D. 
Published: June 2024

AbstractBackgroundNaturally occurring retirement communities (NORCs) are geographic areas (generally high‐rise buildings or neighborhoods) that have a high concentration of individuals 65 years and older. Supportive service programs in NORCs can address resident needs and delay nursing home (NH) admission but understanding what factors are associated with NORC residents requiring NH admission is needed to tailor such programs. Our aim was to examine individual‐ and neighborhood‐level factors associated with NH wait‐list status in NORC residents in Ontario.MethodsWe conducted a population‐based, cross‐sectional study of Ontario adults 65 years of age or older living in a NORC building as of January 1, 2020, by linking a provincial registry of NORC high‐rise buildings with health administrative data. Older adults were classified as being on the NH wait‐list if they had an open application for a NH on the index date. We conducted a multilevel logistic regression analysis using generalized estimating equations to determine individual‐ and neighborhood‐level factors associated with NH wait‐list status, including sociodemographic, clinical, healthcare use, and building factors. We explored the role of sex and age through stratification by sex (male, female) and age (65–80 and 80+ years).ResultsAmong 220,864 NORC residents, 4710 individuals (2.1%) were on the NH wait‐list. Female sex, older age, immigrant status, dementia diagnosis, receiving homecare, multimorbidity, and polypharmacy (five or more unique drug names) were associated with an increased odds of wait‐list status. Several neighborhood‐level variables were associated with a significantly increased likelihood of wait‐list status, including low income, high dependency, high ethnic diversity, and living in a building with supports.ConclusionNORC supportive service programs can be tailored to account for the factors associated with NH wait‐list status, allowing NORC residents who are living in the community to age in their desired place and achieve optimal health outcomes.
Perceived overlap and therapy outcomes among couple clients
Authors: Bartle‐Haring Suzanne , Whiting Riley 
Published: June 2024

AbstractThis article explores couples' perceptions and expectations of closeness in a clinical setting, and how relationship perceptions and expectations are associated with treatment outcomes. Bowen's theory of differentiation suggests that healthy relationships require a balance of autonomy and connection. However, some research suggests that contemporary societal expectations are pushing couples to expect greater degrees of closeness and less autonomy. Utilizing a clinical sample of 185 couples from an on‐campus Couple and Family Therapy training clinic, this article explores couples' perceptions and expectations of relationship closeness utilizing graphics of overlapping circles. Latent profile analysis was conducted to identify three different profile groups based on perceptions and expectations. Wald tests for significant mean differences among the profiles were performed. Results identified significant differences between the three groups for satisfaction and separateness and connectedness variables, number of sessions and termination.
Climate change and commercial property markets
Authors: Ling David C. , Robinson Spenser , Sanderford Andrew R. , Wang Chongyu 
Published: June 2024

AbstractThe economic effect of climate hazard events varies by time and by location. This paper investigates how climate shocks to local property markets transmit to capital markets and provides evidence of the extent to which forward‐looking climate risk is capitalized into the public valuations of those property markets. We first quantify the exposure of real estate portfolios to locations that recently experienced climate events (Event Exposure). Using an event study framework, we find that, in the post‐event period, a one‐standard‐deviation increase in ex‐ante Event Exposure is associated with a 0.2–1.4 percentage points decrease in quarterly stock returns. Cross‐sectional analyses reveal that differences in return effects can be explained by variation in the extent to which the area focuses on climate change. Similarly, we find that forward‐looking climate risk assessment negatively affects firm valuations only in markets with a focus on climate change. Consistent with these findings, we provide evidence that climate events (shocks) induce retail investors (noise traders) to decrease their stock holdings and that blockholders tend to take the opposite side in these transactions. We also show that conditioning on consumer sentiment helps to explain cross‐sectional variation in the response of stock returns to climate events.
Factors influencing serum concentrations of levetiracetam in dogs with epilepsy
Authors: Saint‐Maxent Marine , Juette Tristan , Parent Joane , Castel Aude , Parmentier Thomas 
Published: June 2024

AbstractBackgroundFactors affecting serum concentrations of levetiracetam in dogs are unknown and could affect the efficacy of levetiracetam in controlling seizures in dogs with epilepsy.Hypothesis/ObjectivesHigher PO doses of levetiracetam will be needed in dogs to achieve serum concentrations shown to be effective in humans. Determine factors that could influence serum levetiracetam concentrations and justify dose adjustment in some epileptic dogs.AnimalsSixty‐nine client‐owned dogs with epilepsy treated with levetiracetam alone or in combination, based on 127 trough serum concentration measurements of levetiracetam.MethodsRetrospective cohort study. Linear mixed models were used to assess the effect of patient signalment and concurrent drug administration on serum concentrations of levetiracetam and the effect of serum concentration of levetiracetam on seizure frequency reduction.ResultsThe PO dose of levetiracetam significantly explained changes in serum levetiracetam concentration, and this causal link was stronger with monotherapy (R2 = 0.59, P < .001). Phenobarbital significantly decreased serum levetiracetam concentration in a dose dependent manner (R2 = 0.30, P = .003). Based on our model, a levetiracetam dosage of 99–216 mg/kg/day is necessary to obtain a serum levetiracetam concentration of 20 μg/mL when used alone or concurrently with 7 mg/kg/day of phenobarbital. No other factors were found to influence serum levetiracetam concentrations. No therapeutic range could be identified.Conclusion and Clinical ImportanceOur data suggest that a dosage of 99–216 mg/kg/day of levetiracetam is needed to achieve a serum concentration known to be therapeutically effective in humans, especially when administered concomitantly with phenobarbital.
Unveiling the mechanisms of Moso bamboo's motor function and internal growth stress
Authors: Luan Yu , Yang Yuting , Jiang Menghong , Liu Huanrong , Ma Xinxin , Zhang Xiubiao , Sun Fengbo , Fang Changhua 
Published: June 2024

Summary

Bamboo, a renewable resource with rapid growth and an impressive height‐to‐diameter ratio, faces mechanical instability due to its slender structure. Despite this, bamboo maintains its posture without breaking in its battle against environmental and gravitational forces. But what drives this motor function in bamboo?

This study subjected Moso bamboo (Phyllostachys edulis) to gravitational stimulation, compelling it to grow at a 45° angle instead of upright. Remarkably, the artificially inclined bamboo exhibited astonishing shape control and adjustment capabilities.

The growth strain was detected at both macroscopic and microscopic levels, providing evidence for the presence of internal stress, namely growth stress. The high longitudinal tensile stress on the upper side, along with a significant asymmetry in stress distribution in tilted bamboo, plays a pivotal role in maintaining its mechanical stability.

Drawing upon experimental findings, it can be deduced that the growth stress primarily originates from the broad layers of fiber cells. Bamboo could potentially regulate the magnitude of growth stress by modifying the number of fiber cell layers during its maturation process. Additionally, the microfibril angle and lignin disposition may decisively influence the generation of growth stress.
Oral cancer diagnosis communication: Impact of an educational intervention using the SPIKES protocol
Authors: Gomes Rita Fabiane Teixeira , Herpich Tiago Luis , Braun Liliana Wolf , Ferri Camila Alves , Umpierre Roberto Nunes , Romanini Juliana , Santos‐Silva Alan Roger , Carrard Vinicius Coelho 
Published: June 2024

AbstractObjectiveThis study evaluated the influence of a single educational intervention on the perception and knowledge of strategies for communicating oral cancer diagnoses.MethodsA educational intervention, 72 dentists and 41 dental undergraduates participated in the ‘Maio Vermelho Project’, a continuing education activity. Participants completed a 14‐question online questionnaire concerning their experiences and perceptions of delivering difficult news. The educational intervention featured an interview illustrating the SPIKES protocol, broadcast on YouTube.ResultsParticipants had a mean age of 40 years. A minority (21.2%) had encountered or experienced communicating an oral cancer diagnosis. Exposure to lectures on this topic during their education was uncommon (22.1%) but more prevalent among students. After the intervention, confidence in communicating a cancer diagnosis (29.2%) and addressing the patient's family (30.1%) in line with the SPIKES protocol increased.ConclusionA training deficit persists in delivering cancer diagnoses, highlighting the need for educational interventions to empower students and professionals in this critical procedure. Integration of this topic into the dental undergraduate curriculum is imperative. Clinical Relevance: Effectively communicating a cancer diagnosis poses challenges to healthcare professionals, impacting treatment outcomes. Implementing educational interventions ensures that professionals are well prepared to navigate this complex task, ultimately improving patient care.
Construction of oral squamous cell carcinoma organoids in vitro 3D‐culture for drug screening
Authors: Zhang Xin‐Yuan , Sui Yi , Shan Xiao‐Feng , Wang Lu‐Ming , Zhang Lei , Xie Shang , Cai Zhi‐Gang 
Published: June 2024

AbstractObjectivePatient‐derived organoids are potent pre‐chemotherapy models. Due to limited research on diverse types of oral squamous cell carcinoma (OSCC) and construction efficiency, our goal was to optimize OSCC organoid models from various sites and assess drug responsiveness.MethodsWe screened and optimized culture media, employing three‐dimensional techniques to construct human‐derived oral squamous cell carcinoma (OSCC) organoid models in vitro. Morphological validation, immunofluorescence analysis, tissue origin verification, and Short Tandem Repeat (STR) sequencing confirmed the consistency between organoids and source tissues. These organoid models were then subjected to varying concentrations of anticancer drugs, with subsequent assessment of cell viability to calculate IC50 values.ResultsTwenty‐nine surgical specimens yielded an 86.2% success rate in culturing 25 organoids in vitro. Morphological consistency confirmed nuclear atypia and positive expression of K5, P40, and E‐cadherin, indicating squamous epithelial origin. Cultured complex organoids included α‐SMA+ tumour‐associated fibroblasts and tumour stem cells expressing CD44 and Ki67. STR sequencing affirmed genomic homogeneity between cultured organoids and source tissues. Drug sensitivity testing revealed diverse responses among organoids, highlighting their value for assessing drug sensitivity.ConclusionsAn efficient OSCC organoid culture system for personalized in vitro drug sensitivity screening was established, laying the foundation for precise treatment development.
Evaluation of predictive ability of linear type gonadal traits on reproductive capacity of breeding dairy bulls
Authors: Mandal Dilip Kumar , Kumar Mahesh , Tyagi Shrikant 
Published: June 2024

AbstractDimensions of linear type traits facilitate selection of livestock for breeding and rearing. To date, use of linear type traits for selection of breeding bulls is highly concentric to scrotal circumference (SC), with probable overlook to other important traits. Present study reported the importance of various gonadal linear type traits on spermatozoa production, age‐related changes in gonadal linear type traits of bulls and predictive ability of these traits on bulls' reproductive potentials. Among all gonadal traits, testicular density (TD), scrotal volume (SV), paired testicular weight (PWT) and SC were found most important predictor variables in order, which can discriminate between good/poor breeding bulls, that is, produced frozen semen doses (FSD) or not. Dimensions of gonadal traits increased significantly up to 36 months age and thereafter, development became slow and negligible. In contrast, TD decreased by 30%, 51%, 64%, 68% and 71% at 12, 24, 36, 48 and >49 months age, respectively, from its base value at 6 months. Bulls of lower TD (≤0.88 g/cm3) had significantly higher ejaculate volume (+9%), sperm motility, sperm concentration (+100 million/mL) and sperm output (+26%)/ejaculate as compared to bulls of higher TD (>0.88 g/cm3). Discriminant function was developed using TD, SV, PWT and SC to identify bulls of superior reproductive potentials. It was concluded that among the investigated traits, TD was the strongest to discriminate between FSD and Non‐FSD bulls. Therefore, our findings suggested that TD could be more potential trait than SC for dairy bulls' breeding soundness evaluation and assessment of reproductive ability.
Tests under simple order in one‐way ANCOVA
Authors: Mondal Anjana , Kumar Somesh 
Published: June 2024

AbstractAnalysis of covariance (ANCOVA) models are used when apart from the main treatments, some covariates also affect the response variable. In this article, the problem of testing the homogeneity of treatment effects against ordered alternatives is addressed in a fixed effects one‐way ANCOVA model when error variances are heterogeneous. The likelihood ratio test (LRT) and two approximate tests based on the asymptotic distributions of some union‐intersection type test statistics are proposed. A parametric bootstrap technique has been used to implement the LRT and its asymptotic validity is proved. A method to construct simultaneous confidence intervals is proposed. All the test procedures are further extended to the case of more than one covariate. The robustness of tests is also studied under departure from normality. Extensive simulation studies show that the proposed test procedures perform well in terms of achieving the nominal size value and good power values.
Child temperamental negative affectivity moderates the relation between interparental conflict and child cortisol recovery
Authors: Nguyen Phuong , Schermerhorn Alice C. 
Published: June 2024

AbstractThis study examined the relation between interparental conflict and cortisol recovery, with child temperamental negative affectivity as the moderator. Children (n = 118) ages 9–11 years observed an argument between their parents in the lab and provided saliva samples for cortisol assays. Children also reported levels of interparental conflict, and mothers reported their child's negative affectivity. Results showed that youths with high levels of negative affectivity experienced less cortisol recovery as interparental conflict levels increased. Further, demonstrating some support for differential susceptibility, youths with higher levels of negative affectivity exhibited less recovery at high levels of parental conflict but greater recovery at low levels of parental conflict, compared to peers with lower scores on negative affectivity. We also found that children with low levels of negative affectivity exhibited greater recovery as rates of interparental conflict increased. In summary, this study sheds light on sources of variability in cortisol recovery as it relates to interparental disharmony.
Transcription factor OsNF‐YC1 regulates grain size by coordinating the transcriptional activation of OsMADS1 in Oryza sativa L.
Authors: Cui Zhibo , Wang Xiaowen , Dai Yongdong , Li Yangyang , Ban Yijie , Tian Weijiang , Zhang Xiaobo , Feng Xinyu , Zhang Xuefei , Jia Luqi , He Guanghua , Sang Xianchun 
Published: June 2024

SUMMARYGrain weight, grain number per panicle, and the number of panicles are the three factors that determine rice (Oryza sativa L.) yield. Of these, grain weight, which not only directly determines rice yield but also influences appearance and quality, is often considered the most important for rice production. Here, we describe OsNF‐YC1, a member of the NF‐Y transcription factor family that regulates rice grain size. OsNF‐YC1 knockout plants (osnf‐yc1), obtained using CRISPR‐Cas9 technology, showed reduced grain weight due to reduced width and thickness, with no change in grain length, leading to a slenderer grain shape. Downregulation of OsNF‐YC1 using RNA interference resulted in similar grain phenotypes as osnf‐yc1. OsNF‐YC1 affects grain formation by regulating both cell proliferation and cell expansion. OsNF‐YC1 localizes in both the nucleus and cytoplasm, has transcriptional activation activity at both the N‐terminus and C‐terminus, and is highly expressed in young panicles. OsNF‐YC1 interacts with OsMADS1 both in vivo and in vitro. Further analysis showed that the histone‐like structural CBFD‐NFYB‐HMF domain of OsNF‐YC1 conserved in the OsNF‐YC transcription factor family can directly interact with the MADS‐box domain of OsMADS1 to enhance its transcriptional activation activity. This interaction positively regulates the expression of OsMADS55, the direct downstream target of OsMADS1. Therefore, this paper reveals a potential grain size regulation pathway controlled by an OsNF‐YC1‐OsMADS1‐OsMADS55 module in rice.
Effects of Time-Dependent Adenosine Triphosphate Consumption Caused by Neuron Firing on Adenosine Triphosphate Concentrations in Synaptic Boutons Containing and Lacking a Stationary Mitochondrion
Authors: Kuznetsov Andrey V. 
Published: June 2024

Abstract
The precise mechanism behind the supply of adenosine triphosphate (ATP) to approximately half of the presynaptic release sites in axons that lack a stationary mitochondrion is not fully understood. This paper presents a mathematical model designed to simulate the transient ATP concentration in presynaptic en passant boutons. The model is utilized to investigate how the ATP concentration responds to increased ATP demand during neuronal firing in boutons with a stationary mitochondrion and those without one. The analysis suggests that neuron firing may cause oscillations in the ATP concentrations, with peak-to-peak amplitudes ranging from 0.06% to 5% of their average values. However, this does not deplete boutons lacking a mitochondrion of ATP; for physiologically relevant values of model parameters, their concentration remains approximately 3.75 times higher than the minimum concentration required for synaptic activity. The variance in average ATP concentrations between boutons containing a stationary mitochondrion and those lacking one ranges from 0.3% to 0.8%, contingent on the distance between the boutons. The model indicates that diffusion-driven ATP transport is rapid enough to adequately supply ATP molecules to boutons lacking a stationary mitochondrion.
Design of High-Performance Triple-Axis Cross Pivots
Authors: Serafino Simone , Bruzzone Luca , Fanghella Pietro , Verotti Matteo 
Published: June 2024

Abstract
Cross-axis flexural pivots are increasingly implemented in mechanical systems due to their high precision and wide range of motion. However, designing high-performance pivots in terms of low-axis drift, low rotational stiffness, and low values of maximum stress remains a challenging task. In fact, these features often behave antagonistically to each other. In this paper, the design of a novel family of high-performance cross-axis pivots is presented. The compliant joints are obtained by the composition of two crossing flexible elements with initially curved axis, and of one auxiliary flexure with straight axis. Two different arrangements, that depend on the constraints layout, are proposed. Chained beam constraint model and nonlinear finite element analysis are implemented for the analysis of the kinetostatic response of the pivots. The effects of initial curvature and orientation of the flexures on axis drift, stiffness, and maximum stress, are investigated and reported in the form of design maps. A global performance index, that embodies the above-mentioned features and captures the overall kinetostatic behavior of the pivot, is introduced. The design maps and the global index serve as key tools for the design procedure, giving insight into the antagonistic issue and leading to the determination of the best tradeoff solutions that meet the application requirements. An experimental campaign is conducted to compare the performance improvement of triple-axis pivots with respect to a benchmark double-axis joint, and to validate the design method.
Rigid-Elastic Combined Metamaterial Beam With Tunable Band Gaps for Broadband Vibration Suppression
Authors: Zhang Jiazhen , Peng Xuzhang , Yu Dewen , Hu Guobiao , Yang Yaowen 
Published: June 2024

Abstract
Extensive research efforts have been dedicated to exploring the application of metamaterial beams for vibration suppression. However, most existing designs primarily focused on utilizing the translational motion of local resonators to create band gaps. To address this limitation of employing solo motion to induce a relatively narrow band gap, this study proposes a novel design: a rigid-elastic combined metamaterial beam utilizing both translational and rotational motions of local resonators. Theoretical framework development involves extending the transfer matrix method to incorporate rigid bodies, with analytical results validated through finite element simulations and experimental data. Compared to conventional metamaterial beams, the proposed design exhibits an additional wide band gap in the low-frequency region that can be utilized for broadband vibration suppression. A parametric study elucidates the influences of geometric parameters on band gap formation, followed by an exploration of the tunability of the proposed meta-beam through a graded scheme and optimization strategy. In particular, a multiple-objective optimization approach is employed to enlarge the vibration suppression region and enhance vibration suppression ability. The optimized meta-beam demonstrates a remarkable 45% wider dominant suppression region and a 14% lower average transmittance compared to a uniform model.