bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rasch analysis provides new insights into the measurement properties of the neck disability index
Authors: van der Velde Gabrielle , Beaton Dorcas , Hogg‐Johnston Sheilah , Hurwitz Eric , Tennant Alan 
Published: March 2009

AbstractObjectiveThe most widely used neck‐specific measure in intervention trials is the 10‐item Neck Disability Index (NDI), which is assumed to be a unidimensional interval scale, as shown by how NDI data are scored, analyzed, and interpreted. Our objective was to use modern measurement methods to test this assumption (and thereby to also test the validity of calculating summed scores and parametric statistics on NDI data) through Rasch analysis.MethodsNDI data from 521 trial subjects with neck pain were fit to the Rasch model. We examined threshold ordering of NDI items, fit of data to model expectations, presence of differential item functioning, and whether or not the set of NDI items collectively measure a single construct, which is a requirement for calculating summative scores.ResultsThere was a lack of fit of data to the Rasch model (χ2 = 140.35, 70 df; P < 0.001). Five items (personal care, lifting, headaches, work, and recreation) had disordered response thresholds. Differential item functioning was detected for age and sex. The NDI items did not contribute to a single construct. Unidimensionality and interval scaling were achieved by removing 2 of the 10 items (resulting in the NDI‐8), and converting NDI‐8 ordinal (paper) summative scores to NDI‐8 interval (Rasch‐weighted) scores.ConclusionAs originally proposed and conventionally used, the NDI is not a unidimensional scale, and has only ordinal scaling. This raises fundamental doubts about the practice of calculating change scores and other parametric statistics on NDI data. A revised 8‐item version provides unidimensional interval‐level measurement of neck pain disability.
Expression of MicroRNA‐146a in osteoarthritis cartilage
Authors: Yamasaki Keiichiro , Nakasa Tomoyuki , Miyaki Shigeru , Ishikawa Masakazu , Deie Masataka , Adachi Nobuo , Yasunaga Yuji , Asahara Hiroshi , Ochi Mitsuo 
Published: March 2009

AbstractObjectiveA role of microRNA, which are ∼22‐nucleotide noncoding RNAs, has recently been recognized in human diseases. The objective of this study was to identify the expression pattern of microRNA‐146a (miR‐146a) in cartilage from patients with osteoarthritis (OA).MethodsThe expression of miR‐146a in cartilage from 15 patients with OA was analyzed by quantitative reverse transcription–polymerase chain reaction (RT‐PCR) and by in situ hybridization. Induction of the expression of miR‐146a by cultures of normal human articular chondrocytes following stimulation with interleukin‐1β (IL‐1β) was examined by quantitative RT‐PCR.ResultsAll cartilage samples were divided into 3 groups according to a modification of the Mankin score (grade I = mild OA scored 0–5, grade II = moderate OA scored 6–10, and grade III = severe OA scored 11–14). In grade I OA cartilage samples, the expression of miR‐146a and COL2A1 was significantly higher than that in the other groups (P < 0.05). In grades II and III OA cartilage, the expression of miR‐146a and COL2A1 was decreased, whereas the expression of matrix metalloproteinase 13 (MMP‐13) was elevated in grade II OA cartilage. These data showed that miR‐146a is expressed intensely in cartilage with a low Mankin grade and that miR‐146a expression decreases in parallel with the level of MMP‐13 expression. Tissue section in situ hybridization of primary miR‐146a (pri‐miR‐146a) revealed that pri‐miR‐146a was expressed in chondrocytes residing in all tissue layers, especially in the superficial layer, where it was intensely expressed. The expression of miR‐146 was markedly elevated by IL‐1β stimulation in human chondrocytes in vitro.ConclusionThis study shows that miR‐146 is intensely expressed in low‐grade OA cartilage and that its expression is induced by stimulation of IL‐1β. Thus, miR‐146 might play a role in OA cartilage pathogenesis.
Anti–U3 RNP autoantibodies in systemic sclerosis
Authors: Aggarwal Rohit , Lucas Mary , Fertig Noreen , Oddis Chester V. , Medsger Thomas A. 
Published: March 2009

AbstractObjectiveTo describe the classification, demographic and clinical features, and survival in anti–U3 RNP autoantibody–positive patients with systemic sclerosis (SSc).MethodsMedical records of 108 anti–U3 RNP–positive and 2,471 anti–U3 RNP–negative SSc patients first evaluated during 1985–2003 were reviewed. Anti–U3 RNP antibody was detected by protein and RNA immunoprecipitation. Disease classification, demographic and clinical features, organ system involvement, and survival were compared between the 2 patient groups, by Student's t‐test, chi‐square analysis, and Mantel‐Haenszel test.ResultsThe anti–U3 RNP–positive group had a higher proportion of African American patients (27% versus 5%; P < 0.001) and male patients (29% versus 19%; P = 0.021), and was younger at the time of first physician diagnosis (mean age 42.8 years versus 47.4 years; P = 0.001). The 2 groups had similar proportions of patients with diffuse cutaneous involvement (47% and 45% in those with and those without anti–U3 RNP, respectively). However, among patients with diffuse cutaneous involvement, the mean maximum modified Rodnan skin score was significantly lower in the anti–U3 RNP group (22.3 versus 27.9; P < 0.001). Skeletal muscle involvement was more frequent in anti–U3 RNP–positive patients (25% versus 14%; P = 0.002), as was “intrinsic” pulmonary arterial hypertension (PAH) (31% versus 13%; P < 0.001). The frequency of gastrointestinal involvement, cardiac involvement, pulmonary fibrosis, and “renal crisis” did not differ significantly between the 2 groups. Survival was worse in the anti–U3 RNP–positive group (hazard ratio 1.38 [95% confidence interval 1.05–1.82]). PAH was the most common known cause of death in patients with anti–U3 RNP (30%, versus 10% in the anti–U3 RNP–negative group; P < 0.001).ConclusionThe present findings demonstrate that the frequencies of African American race and male sex are greater among SSc patients with anti–U3 RNP antibody than those without, and the former group is younger at SSc diagnosis. Anti–U3 RNP–positive patients have more frequent skeletal muscle involvement and PAH, the latter being the most common cause of death.
Extranodal lymphoid microstructures in inflamed muscle and disease severity of new‐onset juvenile dermatomyositis
Authors: López De Padilla Consuelo M. , Vallejo Abbe N. , Lacomis David , McNallan Kelly , Reed Ann M. 
Published: March 2009

AbstractObjectiveJuvenile dermatomyositis (DM) is an autoimmune disease of childhood characterized by lesions in skin and muscle that are populated by plasmacytoid dendritic cells (PDCs) and lymphocyte infiltrates. We undertook this study to examine the cellular composition, organization, and molecular milieu of the cellular infiltrates in muscle in juvenile DM and to correlate the infiltrates with clinical disease manifestations.MethodsSince PDCs and lymphocyte foci express CCL19 and CCL21, we investigated for in situ formation of lymphoid microstructures that could be sites of extranodal immune activation.ResultsAnalyses of muscle biopsy samples from children with new‐onset juvenile DM showed 3 categories of lesions: diffuse infiltrates, lymphocytic aggregates lacking follicle‐like organization, and follicle‐like structures. The last of these exhibited elements of classic lymphoid follicles, including networks of follicular dendritic cells and high endothelial venules. They also expressed high levels of CXCL13 and lymphotoxins known to support lymphoid organogenesis. There were also resident naive CD45RA+ T cells and maternally derived B cells and PDCs. Patients with diffuse infiltrates or lymphocytic aggregates were responsive to standard therapy with steroids and methotrexate, but those with follicle‐like structures tended to have severe disease that required additional agents such as intravenous Ig or rituximab.ConclusionThese data suggest that lymphoneogenesis is a component of the early disease process in juvenile DM. Ectopic lymphoid structures could indicate a severe course of disease; their early detection could be a tool for disease management.
Is 18F‐fluorodeoxyglucose positron emission tomography scanning a reliable way to assess disease activity in takayasu arteritis?
Authors: Arnaud Laurent , Haroche Julien , Malek Zoulikha , Archambaud Frédérique , Gambotti Laetitia , Grimon Gilles , Kas Aurélie , Costedoat‐Chalumeau Nathalie , Cacoub Patrice , Toledano Dan , Cluzel Philippe , Piette Jean‐Charles , Amoura Zahir 
Published: March 2009

AbstractObjective18F‐fluorodeoxyglucose–positron emission tomography (FDG‐PET) scanning has been proposed as a new way of assessing disease activity in Takayasu arteritis (TA), but previous studies have used the nonvalidated National Institutes of Health (NIH) global activity criteria, and thus might be biased. This study was undertaken to determine the value of PET scanning for assessment of disease activity in TA, by comparing PET scan data with clinical, biologic, and magnetic resonance imaging (MRI) data assessed separately.MethodsTwenty‐eight patients with TA (according to the American College of Rheumatology criteria) underwent a total of 40 PET scans. Images were reviewed by 2 pairs of independent nuclear medicine physicians and assessed for pattern and intensity of vascular uptake. TA activity data were obtained within 15 days of the PET scans.ResultsPET scanning revealed abnormal vascular uptake in 47% of the 40 examinations. The uptake intensity grade was 0 in 7 scans, grade 1 in 7 scans, grade 2 in 13 scans, and grade 3 in 13 scans. Morphologic analysis was conducted by grading the pattern of the vascular uptake as diffuse (73%), segmental (20%), or focal (13%). There was a trend toward an association between clinically active disease and the semiquantitative assessment of FDG uptake (P = 0.08). We found no statistical association between levels of acute‐phase reactants and intensity of uptake. There was no significant association between the semiquantitative assessment of FDG uptake and the presence of vascular wall thickening (P = 0.23), gadolinium uptake (P = 0.73), or the presence of vascular wall edema (P = 0.56).ConclusionOur findings indicate that there is no association between FDG vascular uptake intensity and clinical, biologic, or MRI assessment of disease activity. Previous studies using the nonvalidated NIH global activity criteria are likely biased.
The impact of gross anatomy on the future head and neck surgeon
Authors: Archibald David J. , Carlson Matthew L. 
Published: April 2009

AbstractGross anatomy is not only a rite of passage for medical students as they enter the world of practicing medicine but may also be an unrecognized fork in the road in their pursuit of choosing a medical specialty. Otolaryngology: head and neck surgery tends to be poorly represented in medical school curriculum, often only offered as an elective rotation. However, head and neck anatomy remains a constant in most medical schools, granting some exposure to otolaryngology whether students realize it or not. A common thread among most head and neck surgeons in their decision to pursue this surgical specialty is a love for head and neck anatomy, spawned in that first year gross anatomy course. This first and potentially only exposure to otolaryngology should be optimized, as it can have a profound effect in the selection of otolaryngology as a specialty. This introduction can be facilitated by (1) inviting otolaryngology residents to assist during the dissection of the head and neck, (2) soliciting otolaryngology attending physicians to provide clinical correlation lectures, and (3) anatomy professors should identify students who excel in the head and neck portion of the curriculum and direct them towards otolaryngology mentors. There may be a great missed opportunity if a career in otolaryngology is not discussed with students during the dissection of the head and neck. Anat Sci Ed 2:89–90, 2009. © 2009 American Association of Anatomists.
From Supramolecular Organoplatinum(II) Nanowires to Platinum‐Containing Nanocomposites
Authors: Lu Wei , Ng Kwan‐Ming , Che Chi‐Ming 
Published: April 2009

AbstractSorting themselves out: Organometallic supramolecular nanowires are self‐assembled from hybrid cyclometalated PtII complexes and used as templates or precursors for various nanocomposites, such as Pt§SiO2 nanotubes and Pt§carbon nanolayers.magnified image
Der Beitrag von Profilblechdecken zur passiven Kühlung
Authors: Döring Bernd , Feldmann Markus , Kuhnhenne Markus 
Published: April 2009

AbstractDie Ausnutzung der thermischen Speichermasse eines Gebäudes zur Beeinflussung der Raumtemperaturen bzw. zur Reduzierung des Energieverbrauchs war in der Vergangenheit Gegenstand zahlreicher Forschungsvorhaben. Um den Einfluss der Speichermasse ermitteln zu können, werden häufig thermische Gebäudesimulationsprogramme eingesetzt, aber auch die aktuelle Fassung von DIN V 18599 berücksichtigt die Wirkung der Wärmekapazität der raumumfassenden Flächen. Sowohl bei Anwendung von DIN V 18599 als auch bei der Gebäudesimulation geht man dabei von einer eindimensionalen Schichtenfolge für Wände und Decken aus. Es gibt jedoch Bauteile, wie z. B. Profilblechdecken, bei denen diese Annahme nicht zutreffend ist. In diesem Bericht werden nun über die Auswertung dynamischer FEM‐Berechnungen für inhomogene Deckenaufbauten Ersatzgrößen bestimmt, so dass die Definition einer thermisch äquivalenten Decke als eindimensionales Modell möglich ist. Für ausgewählte Beispiele wird die Wirksamkeit dieser Decken hinsichtlich ihrer Wärmeaufnahme und ‐abgabe untersucht.
Ermittlung des Wasserdampfdiffusionswiderstandes von Baustoffen in Abhängigkeit von der Baustofftemperatur
Authors: Pötzsch Nicol , Rüther Norbert 
Published: April 2009

AbstractAnalog zu dem in DIN EN ISO 12572 beschriebenen Messverfahren zur Ermittlung des Wasserdampfdiffusionswiderstandswertes μ von Baustoffen, wurden Untersuchungen zum Einfluss der Temperatur auf den Diffusionswiderstand durchgeführt. Die Untersuchungen erfolgten sequenziell bei ausgewählten Temperaturstufen von –10, –5, 0, 10 sowie 50 °C. Untersucht wurden zwei Holzwerkstoffe (MDF, OSB), ein Wärmedämm‐Verbundsystem, ein Putzsystem und ein EPS‐Dämmstoff. Anhand der Ergebnisse kann darauf geschlossen werden, dass die Temperatur innerhalb der untersuchten Grenzen einen Einfluss auf den Materialkennwert μ hat.
How Does the Axial Ligand of Cytochrome P450 Biomimetics Influence the Regioselectivity of Aliphatic versus Aromatic Hydroxylation?
Authors: de Visser Sam P. , Tahsini Laleh , Nam Wonwoo 
Published: April 2009

AbstractHow deep is your orbital? Density functional theory studies on the axial ligand effect of aliphatic versus aromatic hydroxylation of ethylbenzene by iron–oxo complexes with a variable axial ligand show that strong (anionic) ligands pull the metal inside the plane of the haeme and destabilise cationic intermediates through orbital interactions (see picture).magnified imageThe catalytic activity of high‐valent iron–oxo active species of heme enzymes is known to be dependent on the nature of the axial ligand trans to the iron–oxo group. In a similar fashion, experimental studies on iron–oxo porphyrin biomimetic systems have shown a significant axial ligand effect on ethylbenzene hydroxylation, with an axial acetonitrile ligand leading to phenyl hydroxylation products and an axial chloride anion giving predominantly benzyl hydroxylation products. To elucidate the fundamental factors that distinguish this regioselectivity reversal in iron–oxo porphyrin catalysis, we have performed a series of density functional theory calculations on the hydroxylation of ethylbenzene by [FeIVO(Por+.)L] (Por=porphyrin; L=NCCH3 or Cl−), which affords 1‐phenylethanol and p‐ethylphenol products. The calculations confirm the experimentally determined product distributions. Furthermore, a detailed analysis of the electronic differences between the two oxidants shows that their reversed regioselectivity is a result of differences in orbital interactions between the axial ligand and iron–oxo porphyrin system. In particular, three high‐lying orbitals (π*xz, π*yz and a2u), which are singly occupied in the reactant complex, are stabilised with an anionic ligand such as Cl−, which leads to enhanced HOMO–LUMO energy gaps. As a consequence, reactions leading to cationic intermediates through the two‐electron reduction of the metal centre are disfavoured. The aliphatic hydroxylation mechanism, in contrast, is a radical process in which only one electron is transferred in the rate‐determining transition state, which means that the effect of the axial ligand on this mechanism is much smaller.
ChemInform Abstract: New Molecular Species of Potential Interest to Atmospheric Chemistry: Isomers on the [H, S2, Br] Potential Energy Surface
Authors: de Oliveira‐Filho Antonio Gustavo S. , Aoto Yuri Alexandre , Ornellas Fernando R. 
Published: April 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Element Lines: Bonding in the Ternary Gold Polyphosphides, Au2MP2 with M: Pb, Tl, or Hg
Authors: Wen Xiao‐Dong , Cahill Thomas J. , Hoffmann Roald 
Published: April 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Peculiar High‐Pressure Behavior of BiMnO3.
Authors: Belik Alexei A. , Yusa Hitoshi , Hirao Naohisa , Ohishi Yasuo , Takayama‐Muromachi Eiji 
Published: April 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: EuAgxAl11‐x with the BaCd11‐Type Structure: Phase Width, Coloring, and Electronic Structure.
Authors: Wang Fei , Pearson Karen Nordell , Miller Gordon J. 
Published: April 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Effect of Ga Content on the Instantaneous Structure of Al(1‐x)GaxPO4 Solid Solutions at High Temperature.
Authors: Cambon Olivier , Haines Julien , Cambon Martine , Keen David A. , Tucker Matthew G. , Chapon Laurent , Hansen Niels K. , Souhassou Mohamed , Porcher Florence 
Published: April 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Ab initio Structure Determination of β‐La2WO6.
Authors: Chambrier M.‐H. , Kodjikian S. , Ibberson R. M. , Goutenoire F. 
Published: April 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Structural and Magnetic Properties of the Quaternary Oxides Ba6Ln2Fe4O15 (Ln: Pr and Nd).
Authors: Abe Kyosuke , Doi Yoshihiro , Hinatsu Yukio , Ohoyama Kenji 
Published: April 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: An Investigation of the High‐Al Part of the Al—Pd—Ru Phase Diagram at 790—900 °C.
Authors: Pavlyuchkov D. , Grushko B. , Velikanova T. Ya. 
Published: April 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Combustion Synthesis of Triangular and Multifunctional ZnO1‐xNx (x ≤ 0.15) Materials.
Authors: Mapa Maitri , Gopinath Chinnakonda S. 
Published: April 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The NCN‐Type Pincer Complex of Palladium(II) with a 2,6‐Bis(2‐pyridyl)‐4‐tert‐butylbenzene Tridentate Ligand: Synthesis, Structure and Catalytic Activity in the Mizoroki—Heck Reaction.
Authors: Hirano Yuichi , Saiki Yuji , Taji Hideki , Matsukawa Shiro , Yamamoto Yohsuke 
Published: April 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Highly Efficient Molybdenum‐Based Catalysts for Enantioselective Alkene Metathesis.
Authors: Malcolmson Steven J. , Meek Simon J. , Sattely Elizabeth S. , Schrock Richard R. , Hoveyda Amir H. 
Published: April 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: 1,3,4‐Oxadiazole/Thiadiazole and 1,2,4‐Triazole Derivatives of Biphenyl‐4‐yloxy Acetic Acid: Synthesis and Preliminary Evaluation of Biological Properties.
Authors: Kumar Harish , Javed Sadique A. , Khan Suroor A. , Amir Mohammad 
Published: April 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Remarkable Substituent Effects on the Oxidizing Ability of Tetraarylbismuthonium Tetrafluoroborates in Alcohol Oxidation.
Authors: Matano Yoshihiro , Suzuki Takeshi , Iwata Takaharu , Shinokura Tomonori , Imahori Hiroshi 
Published: April 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.