bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterizing sand transport with various micro‐ridge spacings and heights
Authors: Jia Wenru , Li Xiuming , Li Shengyu , Li Qing , Wang Shijie , Yan Haiming , Xie Baoni , Wei Hao 
Published: May 2024

AbstractIn arid regions, the use of ridge cover as a traditional agricultural strategy has been effective in mitigating soil wind erosion. However, few studies have focused on the sand transport characteristics of different micro‐ridge spacings and heights. This study aimed to identify the mechanism by which ridges change the near‐surface sand transport. In a controlled wind tunnel environment, the aeolian sand flux structure and sand transport flux (qz) at heights from 0 to 0.7 m were measured. The results showed that, compared with no ridges, ridge covering could significantly modify the structure of aeolian sand flux near the surface, yielding a substantial reduction in the proportion of sand transport to the total sand transport in the 0‐ to 0.1‐m height layer. In the absence of ridges, blown sand was mainly concentrated in the 0‐ to 0.1‐m height layer, and qz decreased exponentially as the height increased. With various micro‐ridge spacings and heights, when H was less than 0.1 m and L was more than 15H, the blown sand also remained concentrated in the 0‐ to 0.1‐m height layer, and qz decreased exponentially as the height increased. When H increased to 0.15 m from 0.1 m and L decreased from 15H to 5H, the height of the blown sand was concentrated in the 0.3‐ to 0.4‐m layer. The blown sand layer of most ridge structures was concentrated at a height of 0.1–0.4 m, and the structure of the aeolian sand flux resembled an ‘elephant nose effect’. The total sand transport rate of all ridge structures was significantly lower than that with no ridges, indicating that a reasonable ridge structure can effectively prevent wind erosion.
Predisposing, triggering and runout processes at a permafrost‐affected rock avalanche site in the French Alps (Étache, June 2020)
Authors: Cathala Maëva , Bock Josué , Magnin Florence , Ravanel Ludovic , Ben Asher Matan , Astrade Laurent , Bodin Xavier , Chambon Guillaume , Deline Philip , Faug Thierry , Genuite Kim , Jaillet Stéphane , Josnin Jean‐Yves , Revil André , Richard Jessy 
Published: May 2024

AbstractAlthough numerous recent studies have explored the relationship between permafrost degradation and rock slope failure, there is still a need for in‐depth investigations to develop relevant hazard assessment approaches. We investigate the predisposing, triggering and propagation processes of a rock avalanche (c. 225,000 m3) that occurred in Vallon d'Étache (France) on 18 June 2020, whose scar was coated by ice and water. Weather records and energy balance models show that the rock avalanche occurred right after the warmest spring and winter since at least 1985, but also right after the spring with the highest water supply anomaly (snowmelt and rainfall). Measured ground surface temperature and geoelectrical surveys reveal that relatively ice‐rich permafrost could exist in the NW face (release area) while it is inexistent below the SE face, contradicting certain permafrost maps. Heat transfer simulations suggest that the rock avalanche occurred during a transition from cold to warm permafrost conditions at failure depth (30 m), with a temperature increase of up to 0.6°C per decade since 2012 (when considering potential snow cover effect), and current temperature ranging between −3 and −1°C, depending on the applied model forcing. This warming certainly contributed to predispose slope to failure. In addition, the shift towards warm permafrost and water infiltration potentially enhancing permafrost degradation along fractures through heat advection or favouring the development of high hydrostatic pressures may have played as triggering factors. Finally, propagation simulations show that the rock avalanche involved several phases with different rheological properties due to the incorporation of snow and material segregation within the deposit. These new insights at various scales highlight the complexity of the triggering and propagation processes of rock slope failure occurring in high mountains, a significant part of which can be linked to snow effects on ground temperature, water supply and rheological properties.
Experimental study on critical sand production pressure gradient at different production stages of high temperature and high pressure tight sandstone gas reservoir
Authors: Li Yi‐Long , Li Cai‐Shen , Tuo Hong , Wu Bei‐Bei , Chen Chang‐Hao 
Published: May 2024

AbstractSand production is a common issue in sandstone gas reservoir development, severely impacting the productivity of sandstone gas wells. In order to thoroughly investigate the sand production characteristics of high‐temperature and high‐pressure tight sandstone gas reservoirs, this study focuses on six core samples from tight sandstone gas reservoirs(three samples with fractures), under reservoir conditions (185 MPa, 160°C), sand production experiments were conducted to thoroughly investigate the sand production patterns in sandstone reservoirs under the combined influence of different effective stresses and production pressure differentials. The results indicate: (1) under the simultaneous increase of effective pressure and production pressure differential, sand production near the wellbore (r = 0.1 m) becomes more likely in the reservoir; (2) in actual reservoirs without fractures near the wellbore (r = 0.1 m), sand production phenomena do not occur; (3) reservoirs with fractures near the wellbore (r = 0.1 m) are more prone to sand production, under an effective stress of 90 MPa, with specimens containing fractures exhibiting a 76.48% lower critical sand production pressure gradient compared to those without fractures; (4) when the pore fluid pressure is 95 MPa, the maximum gas production rate for Well X without sand production is 12.4 × 104 m3/d. The experimental results have guiding significance for the rational production of gas wells in this type of reservoir.
Translation, cultural adaptation and validation of the Swahili Pain Catastrophizing Scale among refugees who survived torture and/or war trauma in Kenya: An observational study
Authors: Kibet Jepkemoi J. , Phillips Joliana S. , Latrous Mariem C. , Khalil Hanan , Morris Linzette D. 
Published: May 2024

AbstractBackground and AimsAccurate assessment of any patient relies on the use of appropriate measurements which are culturally‐ and linguistically‐applicable and valid. The following study aimed to translate, cross‐culturally adapt and test the nomological validity, structural validity, internal consistency, test‐retest reliability, sensitivity‐to‐change and feasibility of the Swahili version of the Pain Catastrophizing Scale (Swa‐PCS) among refugees who survived torture/war trauma living with chronic pain in Kenya.MethodsAn observational study was conducted. Translation and cultural adaptation of the original PCS for the Swahili‐speaking refugee population in Kenya, who survived torture or war trauma was undertaken. Following this process, a validation study was conducted on the newly‐adapted instrument, to ascertain the psychometric properties (nomological validity, structural validity, internal consistency, test‐retest reliability, sensitivity‐to change, and ceiling and floor effects).ResultsFifty participants were included in this study. Correlations between pain catastrophization and fear‐avoidance behavior measures were significant (r = 0.538, p < 0.01). Ceiling effects were 42−48% with no floor effects. Standard errors of measurement values were between 0.938 and 3.38. Minimal‐detectable‐change values were between 2.17 and 7.82. Internal consistency was satisfactory to good, for the whole and subsections respectively (range α = 0.693−0.845). Magnification had the lowest α. Test−retest reliability was also satisfactory to good (range ICC =  0.672−0.878). Confirmatory factor analysis confirmed that the Swa‐PCS had three factors which explained the majority of the variance. Root mean square error of approximation and comparative fit index were calculated for goodness‐of‐fit assessment, and were 0.18 and 0.83, respectively.ConclusionThis study showed that the adapted Swa‐PCS displayed overall satisfactory to good internal consistency, test‐retest reliability and sensitivity‐to‐change. Furthermore, the Swa‐PCS scores were related to fear‐avoidance behavior scores as expected (nomological validity). Structural validation of the Swa‐PCS requires further investigation. Further testing of the psychometric properties of the Swa‐PCS is however warranted.
The protective effect of dietary folate intake on gastric cancer is modified by alcohol consumption: A pooled analysis of the StoP Consortium
Authors: Gonzalez‐Palacios Sandra , Compañ‐Gabucio Laura‐María , Torres‐Collado Laura , Oncina‐Canovas Alejandro , García‐de‐la‐Hera Manuela , Collatuzzo Giulia , Negri Eva , Pelucchi Claudio , Rota Matteo , López‐Carrillo Lizbeth , Lunet Nuno , Morais Samantha , Ward Mary H. , Martin Vicente , Lozano‐Lorca Macarena , Malekzadeh Reza , Pakseresht Mohammadreza , Hernández‐Ramírez Raúl Ulises , Bonzi Rossella , Patel Linia , López‐Cervantes Malaquias , Rabkin Charles S. , Tsugane Shoichiro , Hidaka Akihisa , Trichopoulou Antonia , Karakatsani Anna , Camargo M. Constanza , Curado Maria Paula , Zhang Zuo‐Feng , La Vecchia Carlo , Boffetta Paolo , Vioque Jesús 
Published: May 2024

AbstractDietary folate intake has been identified as a potentially modifiable factor of gastric cancer (GC) risk, although the evidence is still inconsistent. We evaluate the association between dietary folate intake and the risk of GC as well as the potential modification effect of alcohol consumption. We pooled data for 2829 histologically confirmed GC cases and 8141 controls from 11 case–control studies from the international Stomach Cancer Pooling Consortium. Dietary folate intake was estimated using food frequency questionnaires. We used linear mixed models with random intercepts for each study to calculate adjusted odds ratios (OR) and 95% confidence interval (CI). Higher folate intake was associated with a lower risk of GC, although this association was not observed among participants who consumed >2.0 alcoholic drinks/day. The OR for the highest quartile of folate intake, compared with the lowest quartile, was 0.78 (95% CI, 0.67–0.90, P‐trend = 0.0002). The OR per each quartile increment was 0.92 (95% CI, 0.87–0.96) and, per every 100 μg/day of folate intake, was 0.89 (95% CI, 0.84–0.95). There was a significant interaction between folate intake and alcohol consumption (P‐interaction = 0.02). The lower risk of GC associated with higher folate intake was not observed in participants who consumed >2.0 drinks per day, ORQ4v Q1 = 1.15 (95% CI, 0.85–1.56), and the OR100 μg/day = 1.02 (95% CI, 0.92–1.15). Our study supports a beneficial effect of folate intake on GC risk, although the consumption of >2.0 alcoholic drinks/day counteracts this beneficial effect.
Mapping the correlations between bandgap, HOMO, and LUMO trends for meta substituted Zn‐MOFs
Authors: Williamson Kyle I. , Herr Daniel J. C. , Mo Yirong 
Published: May 2024

AbstractBandgap is a key property that determines electrical and optical properties in materials. Modulating the bandgap thus is critical in developing novel materials particularly semiconductors with improved features. This study examines the bandgap, highest occupied molecular orbital (HOMO), and lowest unoccupied molecular orbital (LUMO) energy level trends in a metal organic framework, metal–organic framework 5 (MOF‐5), as a function of Hammett substituent effect (with the constant σm in the meta‐position of the benzene ring) and solvent dielectric effect (with the constant ε). Specifically, experimental design and response surface methodologies helped to assess the significance of trends and correlations between these molecular properties with σm and ε. While the HOMO and LUMO decrease with increasing σm, the LUMO exhibits greater sensitivity to the substituent's electron withdrawing capability. The relative difference in these trends helps to explain why the bandgap tends to decrease with increasing σm.
Performance evaluation of Bi/Zn‐impregnated commercial TiO2 nanoparticles for photocatalytic nitrobenzene decomposition
Authors: Mishra Saurav , Chakinala Nandana , Chakinala Anand G. , Surolia Praveen K. 
Published: May 2024

AbstractBACKGROUNDCommercial TiO2 nanoparticles were subjected to modification through Bi and Zn metal doping. The resulting catalysts were comprehensively characterized, and their performance was then reviewed for removal of model pollutant nitrobenzene in water.RESULTSAmidst the synthesized catalysts, the co‐doping of Bi/Zn (0.25:0.75 wt%) demonstrated the best photocatalytic degradation activity, achieving 95% degradation within 90 min of reaction time, with 2.99 × 10−2 min−1 rate constant value. The involvement of different radicals during the degradation process was elucidated by employing appropriate radical scavengers. Furthermore, the degradation results were investigated applying the first‐order kinetic model, leading to the determination of reaction rate constants and initial rates of the degradation process.CONCLUSIONAn improved photocatalytic activity was observed with metal doping due to the synergistic effect of doped metals with commercial TiO2 and profound charge transfer among them. It was observed that performance was increased with temperature rise in the practical range of application, that is, 5–20 °C. This behavior was due to high rate of movement of charge carriers. Further, involvement and functioning of various radical species such as h+, OH− and O2− in nitrobenzene degradation were successfully established using appropriate radical scavengers. © 2024 Society of Chemical Industry (SCI).
Familial communication and cascade testing following elective genomic testing
Authors: Adelson Sophia M. , Blout Zawatsky Carrie L. , Hickingbotham Madison R. , Bell Megan E. , Platt Dylan M. , Leonhard Jennifer R. , Zoltick Emilie S. , Hajek Catherine A. , Green Robert C. , Christensen Kurt D. 
Published: May 2024

AbstractFamilial communication of results and cascade genetic testing (CGT) can extend the benefits of genetic screening beyond the patient to their at‐risk relatives. While an increasing number of health systems are offering genetic screening as an elective clinical service, data are limited about how often results are shared and how often results lead to CGT. From 2018 to 2022, the Sanford Health system offered the Sanford Chip, an elective genomic test that included screening for medically actionable predispositions for disease recommended by the American College of Medical Genetics and Genomics for secondary findings disclosure, to its adult primary care patients. We analyzed patient‐reported data about familial sharing of results and CGT among patients who received Sanford Chip results at least 1 year previously. Among the patients identified with medically actionable predispositions, 94.6% (53/56) reported disclosing their result to at least one family member, compared with 46.7% (423/906) of patients with uninformative findings (p < 0.001). Of the patients with actionable predispositions, 52.2% (12/23) with a monogenic disease risk and 12.1% (4/33) with a carrier status reported that their relatives underwent CGT. Results suggest that while the identification of monogenic risk during elective genomic testing motivates CGT in many at‐risk relatives, there remain untested at‐risk relatives who may benefit from future CGT. Findings identify an area that may benefit from increased genetic counseling and the development of tools and resources to encourage CGT for family members.
Lymph node tuberculosis‐associated paradoxical immune reconstitution inflammatory syndrome in a non‐HIV patient: Case report and review of literature
Authors: Guimarães André Rodrigues , Bastos Juliana , Santos Lurdes , Silva‐Pinto André 
Published: May 2024

AbstractTuberculosis (TB) is a global health threat, especially in HIV patients who may experience immune reconstitution inflammatory syndrome (IRIS) upon Mycobacterium tuberculosis infection. Diagnosing and defining IRIS in non‐HIV patients remains challenging. A 63‐year‐old male with acute leukaemia underwent induction therapy with a regimen containing fludarabine. Febrile neutropenia led to further investigations, revealing non‐cavitary pulmonary TB, prompting anti‐tuberculosis therapy (ATT) alongside resumed leukaemia treatment with sorafenib. Persistent extra‐pulmonary TB, specifically lymph node involvement, were observed and IRIS was suspected, evidenced by enlarged lymphadenopathies, scrofula, and skin lesions that developed during the 13‐month course of ATT, with no recurrence after its cessation. This article explores a case of lymph node TB‐associated paradoxical IRIS in a non‐HIV leukaemia patient, revealing the intricate interplay between tuberculosis and haematological malignancies and emphasizing the lack of standardized diagnostic criteria and treatment consensus. Challenges in lymph node TB diagnosis and management highlight the need for tailored therapeutic approaches. The report explores the potential immunomodulatory effects of fludarabine and sorafenib, questioning their roles in TB‐IRIS. This case illuminates TB‐IRIS dynamics in non‐HIV patients, urging further research and collaborative efforts to enhance understanding and outcomes. As medical complexities persist, personalized therapeutic approaches and advancements in TB‐IRIS research are crucial.
Discernable machine learning methods for Raman micro‐spectroscopic stratification of mitoxantrone‐induced drug‐resistant cells in acute myeloid leukemia
Authors: Anjikar Ajinkya , Iwasaki Keita , Paneerselvam Rajapandian , Hole Arti , Chilakapati Murali Krishna , Noothalapati Hemanth , Dutt Shilpee , Yamamoto Tatsuyuki 
Published: May 2024

AbstractDrug resistance plays a vital role in both cancer treatment and prognosis. Especially, early insights into such drug‐induced resistance in acute myeloid leukemia (AML) can help to improve treatment plans, reduce costs, and bring overall positive outcomes for patients. Raman spectroscopy provides precise biomolecular information and can provide all these necessities effectively. In this study, we employed machine learning (ML) discrimination of Raman micro‐spectroscopic data of myelocytic leukemia cell line HL‐60 from its drug‐resistant counterpart HL‐60/MX2. Principal component analysis (PCA), linear discriminant analysis (LDA), and logistic regression (LR) methods were evaluated for their ability to identify and discriminate drug resistance in AML cells. Our study demonstrates the power of ML to classify drug‐induced resistance in AML cells utilizing subtle variations in biomolecular information contained in molecular spectroscopic data by obtaining 94.11% and 97.05% classification accuracies by LDA and LR models, respectively. We also showed that the ML methods are discernable. Our findings depict the importance of automation and its optimal usage in cancer study and diagnosis. The results of our study are expected to take ML‐assisted Raman spectroscopy one step closer to making it a generalized tool in medical diagnosis in the future.
Okra extract alleviates lipopolysaccharide‐induced inflammation response through the regulation of bile acids, the receptor‐mediated pathway, and gut microbiota
Authors: Zhou Shanshan , Yang Li , Qiu Xia , Li Bohui , Hu Liang , Tang Zizhong , Li Hua , Li Shanshan , Fang Zhengfeng , Chen Hong 
Published: May 2024

AbstractBACKGROUNDOkra contains flavonoids and vitamin C as antioxidants and it contains polysaccharides as immunomodulators. Flavonoids regulate the inflammatory response in mice and may be related to gut microbiota. This study therefore aimed to investigate the impact of okra extract (OE) on inflammation in mice and to elucidate its underlying mechanism.METHODForty male Kunming (KM) mice were categorized into four groups: the control (CON) group, the lipopolysaccharide stimulation (LPS) group, the 5 mg mL−1 OE intervention (LPS + OE) group, and the 5 mg mL−1 OE supplementation plus mixed antibiotics (LPS + OE + ABX) group.RESULTSThe results showed that, compared with the OE group, the expression of inflammatory signaling pathway genes was upregulated and gut barrier genes were inhibited in the OE + ABX group. The Fxr receptor was activated and the abundance of Akkermansia was increased after OE supplementation, whereas the effect was reversed in the OE + ABX group. Meanwhile, Fxr was correlated positively with Akkermansia.CONCLUSIONThe OE supplementation alleviated the inflammatory response in mice under LPS stimulation, accompanied by changes in gut microbiota and bile acid receptors, whereas the addition of antibiotics caused a disturbance to the gut microbiota in the OE group, thus reducing the effect of OE in alleviating the inflammatory response. © 2024 Society of Chemical Industry.
METTL3aggravates cell damage induced byStreptococcus pneumoniaevia theNEAT1/CTCF/MUC19axis
Authors: Ma Dong‐Bo , Zhang Hui , Wang Xi‐Ling , Wu Qiu‐Ge 
Published: May 2024

AbstractDisruption of the alveolar barrier can trigger acute lung injury. This study elucidated the association of methyltransferase‐like 3 (METTL3) withStreptococcus pneumoniae(SP)‐induced apoptosis and inflammatory injury of alveolar epithelial cells (AECs). AECs were cultured and then infected with SP. Furthermore, the expression of METTL3, interleukin (IL)‐10, IL‐6, tumor necrosis factor‐alpha (TNF‐α), monocyte chemoattractant protein‐1 (MCP‐1), long noncoding RNA nuclear paraspeckle assembly transcript 1 (NEAT1), mucin 19 (MUC19), N6‐methyladenosine (m6A), and NEAT1 after m6A modification were detected by qRT‐PCR, Western blot, and enzyme‐linked immunosorbent, m6A quantification, and methylated RNA immunoprecipitation‐qPCR analyses, respectively. Moreover, the subcellular localization of NEAT1 was analyzed by nuclear/cytosol fractionation assay, and the binding between NEAT1 and CCCTC‐binding factor (CTCF) was also analyzed. The results of this investigation revealed that SP‐induced apoptosis and inflammatory injury in AECs and upregulated METTL3 expression. In addition, the downregulation of METTL3 alleviated apoptosis and inflammatory injury in AECs. METTL3‐mediated m6A modification increased NEAT1 and promoted its binding with CTCF to facilitate MUC19 transcription. NEAT1 or MUC19 overexpression disrupted their protective role of silencing METTL3 in AECs, thereby increasing apoptosis and inflammatory injury. In conclusion, this is the first study to suggest that METTL3 aggravates SP‐induced cell damage via the NEAT1/CTCF/MUC19 axis.