bluuebunny/crossref_metadata_2025_split huggingface dataset:
3‐year follow‐up of 100 consecutive coronary bifurcation lesions treated with Taxus stents and the crush technique
Authors: Chue Colin D. , Routledge Helen C. , Ludman Peter F. , Townend Jonathan N. , Epstein Andrew C.R. , Buller Nigel P. , Doshi Sagar N. 
Published: August 2009

AbstractObjectives: To determine the 3 year safety and efficacy of crush‐stenting with paclitaxel‐eluting stents. Background: The optimum two‐stent strategy for treatment of coronary bifurcation lesions is undetermined. Crush‐stenting is advocated to minimize restenosis through complete circumferential stent coverage; long‐term follow‐up data are lacking. Methods and Results: In a single center prospective registry, 100 consecutive patients with bifurcation lesions were treated with the Crush technique. The vast majority (93%) were true bifurcations, predominantly involving the left anterior descending and diagonal arteries. Technical success was 98%. Final kissing balloon dilatation, which became standard practice during the study, was attempted in 68 patients and successful in 51. Abciximab was used in all cases. There were no peri‐procedural stent thromboses. Follow‐up was 100% at 3 years. Symptom‐driven target lesion revascularisation was 8% at 3 years. Cumulative 3‐year major adverse cardiac events was 28% (7 cardiac deaths, 15 myocardial infarctions, 11 target vessel revascularisations). Absence of a final kissing inflation predicted repeat revascularisation but not death, infarction or stent thrombosis. Three probable stent thromboses occurred, of which two were very late. Conclusion: Where a two‐stent bifurcation strategy is required, Crush‐stenting with paclitaxel‐eluting stents is safe and effective in the long‐term. Failure to perform a final kissing dilatation increases the likelihood of revascularisation but not other adverse events. © 2009 Wiley‐Liss, Inc.
Tibioperoneal trunk pseudoaneurysm coil embolization
Authors: Micari Antonio , Vadalà Giuseppe 
Published: August 2009

AbstractIntroduction: Pseudoaneurysms of the tibioperoneal trunk are rare and can be limb threatening. There are various treatment options to seal pseudoaneuryms both percutaneously and via open surgery. Case report: Description of the case of a large tibioperoneal trunk pseudoaneurysm that has been successfully treated by coil embolization in a patient with a previous endocarditys. Conclusion: Endovascular treatment of pseudoaneurysm should be considered as an alternative treatment option to open surgery. © 2010 Wiley‐Liss, Inc.
Impact of the prehospital ECG on door‐to‐balloon time in ST elevation myocardial infarction
Authors: Rao Anjani , Kardouh Youssef , Darda Saba , Desai Devang , Devireddy Lingareddy , Lalonde Thomas , Rosman Howard , David Shukri 
Published: August 2009

AbstractBackground:National guidelines have been set to achieve door‐to‐balloon time (D2B) is less than 90 minutes to improve outcomes for patients with STEMI. The purpose of this study is to see if a more aggressive approach utilizing prehospital ECGs could improve reperfusion times.Methods:The EMS personnel obtained a 12‐lead ECG during initial assessment in the field from patients with chest pain. The ECG was immediately transmitted to the ER physician by cellular link to a computer receiving station. The ER physician reviewed the ECG digital tracing. The cardiac catheterization laboratory (CCL) team was activated from the patients' homes. Patients were transported from the field directly to the CCL by EMS bypassing the emergency department.Results:The mean D2B for patients with initial ECG in hospital in all three hospitals combined was 90.5 minutes, compared to 60.2 minutes in patients with prehospital ECG. (P < 0.0001). When analyzing the mean D2B in regards to times of presentation, we found a significant reduction in mean D2B in patients presenting during working hours (75 minutes) compared with those presenting during off hours (98 minutes) in the control group. However, with the use of prehospital ECGs, there was a significant reduction in D2B regardless of what time the patient arrived in the ER.Conclusions:Utilizing the prehospital ECG as a tool to bypass ER triage significantly decreases D2B times in patients with STEMI. This technology has the potential to substantially expedite reperfusion therapy in patients with STEMI. © 2009 Wiley‐Liss, Inc.
Bronchopulmonary fistula closure with an Amplatzer Multi‐Fenestrated Septal Occluder
Authors: Boudoulas Konstantinos Dean , Elinoff Jason , Resar Jon R. 
Published: August 2009

AbstractBronchopulmonary fistula, a communication between the bronchial airway and the pleural space, is associated with increased morbidity and mortality often requiring surgical therapy. A successful closure of a fistula from the posterior trachea to the right apical pleural space in a 60‐year‐old man with a history of Barrett's esophagus, esophagectomy, multiple pulmonary infections, and right upper lobectomy using an Amplatzer Multi‐Fenestrated Septal Occluder via a transbronchial approach is reported. © 2009 Wiley‐Liss, Inc.
Analysis of Coherent Heteroclustering of Different Dyes by Use of Threoninol Nucleotides for Comparison with the Molecular Exciton Theory
Authors: Fujii Taiga , Kashida Hiromu , Asanuma Hiroyuki 
Published: August 2009

AbstractTo test the molecular exciton theory for heterodimeric chromophores, various heterodimers and clusters, in which two different dyes were stacked alternately, were prepared by hybridizing two oligodeoxyribonucleotides (ODNs), each of which tethered a different dye on D‐threoninol at the center of the strand. NMR analyses revealed that two different dyes from each strand were stacked antiparallel to each other in the duplex, and were located adjacent to the 5′‐side of a natural nucleobase. The spectroscopic behavior of these heterodimers was systematically examined as a function of the difference in the wavelength of the dye absorption maxima (Δλmax). We found that the absorption spectrum of the heterodimer was significantly different from that of the simple sum of each monomeric dye in the single strand. When azobenzene and Methyl Red, which have λmax at 336 and 480 nm, respectively, in the single strand (Δλmax=144 nm), were assembled on ODNs, the band derived from azobenzene exhibited a small hyperchromism, whereas the band from Methyl Red showed hypochromism and both bands shifted to a longer wavelength (bathochromism). These hyper‐ and hypochromisms were further enhanced in a heterodimer derived from 4′‐methylthioazobenzene and Methyl Red, which had a much smaller Δλmax (82 nm; λmax=398 and 480 nm in the single‐strand, respectively). With a combination of 4′‐dimethylamino‐2‐nitroazobenzene and Methyl Red, which had an even smaller Δλmax (33 nm), a single sharp absorption band that was apparently different from the sum of the single‐stranded spectra was observed. These changes in the intensity of the absorption band could be explained by the molecular exciton theory, which has been mainly applied to the spectral behavior of H‐ and/or J‐aggregates composed of homo dyes. However, the bathochromic band shifts observed at shorter wavelengths did not agree with the hypsochromism predicted by the theory. Thus, these data experimentally verify the molecular exciton theory of heterodimerization. This coherent coupling among the heterodimers could also partly explain the bathochromicity and hypochromicity that were observed when the dyes were intercalated into the duplex.
Crystal Structure of the T(6‐4)C Lesion in Complex with a (6‐4) DNA Photolyase and Repair of UV‐Induced (6‐4) and Dewar Photolesions
Authors: Glas Andreas F. , Schneider Sabine , Maul Melanie J. , Hennecke Ulrich , Carell Thomas 
Published: August 2009

AbstractUV‐light irradiation induces the formation of highly mutagenic lesions in DNA, such as cis‐syn cyclobutane pyrimidine dimers (CPD photoproducts), pyrimidine(6‐4)pyrimidone photoproducts ((6‐4) photoproducts) and their Dewar valence isomers ((Dew) photoproducts). Here we describe the synthesis of defined DNA strands containing these lesions by direct irradiation. We show that all lesions are efficiently repaired except for the T(Dew)T lesion, which cannot be cleaved by the repair enzyme under our conditions. A crystal structure of a T(6‐4)C lesion containing DNA duplex in complex with the (6‐4) photolyase from Drosophila melanogaster provides insight into the molecular recognition event of a cytosine derived photolesion for the first time. In light of the previously postulated repair mechanism, which involves rearrangement of the (6‐4) lesions into strained four‐membered ring repair intermediates, it is surprising that the not rearranged T(6‐4)C lesion is observed in the active site. The structure, therefore, provides additional support for the newly postulated repair mechanism that avoids this rearrangement step and argues for a direct electron injection into the lesion as the first step of the repair reaction performed by (6‐4) DNA photolyases.
Experimental aspects of solid state circular dichroism
Authors: Castiglioni Ettore , Biscarini Paolo , Abbate Sergio 
Published: August 2009

AbstractThe interest of circular dichroism in the solid state is stimulated by several needs, such as the desire to get solvent free spectra, the insolubility of the sample or the intrinsic process in which the sample itself is prepared or manipulated. We approach the argument on the basis of the sampling technique, since each different case calls for specific care in getting proper results. Chirality 21:E28–E36, 2009. © 2009 Wiley‐Liss, Inc.
More tumor‐affected lymph nodes because of the sentinel lymph node procedure but no stage migration, because the 2002 TNM classifies small tumor deposits as pathologic N0 breast cancer
Authors: Bolster Marieke J. , Bult Peter , Wauters Carla A. P. , Strobbe Luc J. A. , Peer Petronella G. M. , Wobbes Theo , Tjan‐Heijnen Vivianne C. G. 
Published: September 2009

AbstractBACKGROUND:Intensified examination of the sentinel lymph node (SN) may result in increased detection of tumor‐affected lymph nodes. The authors of this report hypothesized that the introduction of the SN procedure has led to stage migration because of the intensified workup of SNs by pathologists.METHODS:After the introduction of the SN procedure, 360 patients with operable breast cancer were included prospectively from 2 large hospitals (Hospital A and Hospital B). The prospectively included patients (the “SN era” group) were compared with 88 historic controls from the year 1994 who were diagnosed with primary breast cancer before introduction of the SN procedure.RESULTS:After correcting for classic clinical and pathologic prognostic factors in a multiple logistic regression analysis, the detection frequency of lymph node involvement was significantly higher in the SN era group compared with historic controls (P = .04). However, when using the 2002 TNM classification, in which isolated tumor cells (≤0.2 mm) were categorized as lymph node‐negative disease, no stage migration was observed (P = .98). Also, when analyzing both hospitals (Hospital A vs Hospital B) separately with respect to lymph node involvement, there was no difference, between the SN era and the historic controls (P = .79 and P = .69, respectively). This remained nonsignificant after the analysis was corrected for patient and primary tumor characteristics (P = .85 and P = .66, respectively).CONCLUSIONS:Introduction of the SN procedure has led to the detection of more tumor‐affected lymph nodes because of the intensified workup of SNs by pathologists. However, stage migration did not occur when tumor deposits of ≤0.2 mm were categorized as lymph node‐negative disease, according to the 2002 TNM classification. Cancer 2009. © 2009 American Cancer Society.
Titania Nanocrystals and Adsorptive Nanoporous Polymer Composites: An Enrichment and Degradation System
Authors: Zhang Yonglai , Wei Shu , Zhang Wei , Xu Yi‐Jun , Liu Sen , Su Dang Sheng , Xiao Feng‐Shou 
Published: August 2009

AbstractComposites of titania nanocrystals and adsorptive nanoporous polymers are synthesized via a two‐step solvothermal pathway. These composites are developed as bifunctional materials for both the adsorption of organic compounds and photocatalysis, providing an enrichment and degradation system for the removal of environmental pollutants. The anatase‐phase titania nanoparticles are homogeneously dispersed in the matrix of the nanoporous polymers. The composites exhibit nanoporous structures, high surface areas, and excellent stabilities. Experimental results show that the composites have excellent adsorptive properties for organic compounds in water and air and high photocatalytic activities under UV irradiation. These bifunctional materials may have promising applications in environmental protection.
Environmental enrichment influences survival rate and enhances exploration and learning but produces variable responses to the radial maze in old rats
Authors: Bell J.A. , Livesey P.J. , Meyer J.F. 
Published: August 2009

AbstractWistar rats at 7 (mature), 16 (aging), and 22 (old) months of age spent 70 days in normal laboratory (Social), impoverished (Isolated) or dynamic Enrichment cages. The Enriched cage emphasized spatial re‐arrangements of significant items, and the learning of new routes. Subsequently, Enriched rats at all ages entered a novel environment and escaped from a bright light with significantly shorter latencies than rats from either of the other environments. Mature, aging and some of the old Enriched rats also significantly outperformed their Isolated and Social counterparts in the radial maze. However old Enriched and Isolated animals showed significant variability in relation to the measure of the proportion reaching criterion on this task, and a significantly lower proportion than of old Social rats reached criterion. Enriched rats had a significantly higher survival rate than Social and Isolated animals. These findings are discussed in terms of learning efficiency and behaviors that conserve energy and thereby enhance survival. © 2009 Wiley Periodicals, Inc. Dev Psychobiol 51: 564–578, 2009.
PNSO Ligands as a Tool to Study Metal Bonding of Electron‐Deficient Sulfinyl Groups
Authors: Revés Marc , Riera Antoni , Verdaguer Xavier 
Published: August 2009

AbstractA family of N‐phosphanylsulfinamide (PNSO) ligands with electron‐deficient sulfinyl groups was synthesized. Reaction with Co2–alkyne complexes yields P,S‐bridged complexes. These complexes were used to study the metal bonding of different sulfinyl groups. IR spectroscopy, X‐ray analysis, and Pauson–Khand reactivity studies indicated that electron‐deficient sulfinyl groups provide enhanced S metal bonding. The mean CO stretching frequencies (Δν) for these complexes closely correlates with the χi parameter computed by Tolman for phosphane ligands. Among the studied sulfinyl groups, the trifluoromethyl PNSO ligand afforded the strongest sulfur–metal bond. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Coordination Induction of Nonlinear Molecular Shape in Mesomorphic and Luminescent ZnII Complexes Based on Salen‐Like Frameworks
Authors: Pucci Daniela , Aiello Iolinda , Bellusci Anna , Crispini Alessandra , Ghedini Mauro , La Deda Massimo 
Published: August 2009

AbstractA series of tetradentate dimeric salicylaldimine ligands (H2LnRm) with terminal chains of variable length (Rm) and a central flexible (CH2)n spacer (Ln = 10 and 12) was synthesized. For all ligands, according to their rod‐like molecular shape, mesomorphism characteristic of calamitic systems (nematic and smectic C phases) is observed. The reaction with ZnII acetate dihydrate afforded a series of ZnLnRm derivatives (1–6) that show mesomorphic behaviour only in the presence of the longest terminal tails (R12). Interestingly, the flexibility of the very long spacer in the central core and the presence of the tetrahedral ZnII centre introduce nonlinearity in the central part of the molecule, responsible for the appearance of an intercalated smectic C mesophase. Moreover, the coordination of the ZnII ion to the salen‐like framework induces, in all the corresponding complexes, interesting blue‐light‐emitting properties at room temperature in dichloromethane solution (EQY in the 19–22 % range at about 450 nm), as well as in the solid (EQY: 9 % at about 450 nm) or, when present, in the mesophase (EQY 8 % at 440 nm).(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Analysis of the Interaction between Adenine Nucleobase and Metal‐Malonato Complexes (Eur. J. Inorg. Chem. 26/2009)
Authors: Pérez‐Yáñez Sonia , Castillo Oscar , Cepeda Javier , García‐Terán Juan P. , Luque Antonio , Román Pascual 
Published: August 2009

AbstractThe cover picture shows the paddle‐wheel motif adopted by the dinuclear complexes in which the metal centres are held together by bridging malonato and bridging neutral adenine ligands, the countercomplementarity of the bridging ligands responsible for their ferromagnetic behaviour, and the molecular recognition processes that take place between the protonated adeninium cations and the anionic copper‐malonato fragments. Details are discussed in the article by O. Castillo, A. Luque et al. on p. 3889 ff.
A Novel, Highly Efficient, One‐Pot Synthesis of 1,4‐Dihydroquinoline Derivatives in the Presence of a Pd(OAc)2/DABCO Catalytic System
Authors: Wu Xiao‐Jin , Xu Xiao‐Ping , Su Xiao‐Ming , Chen Gang , Zhang Yong , Ji Shun‐Jun 
Published: August 2009

AbstractThe Pd(OAc)2/DABCO catalytic system was first found to be highly efficient for C–N cross‐coupling reactions. With the aid of this transformation, a variety of new 1,4‐dihydroquinoline derivatives were synthesized from o‐halobenzaldehydes and various β‐enaminones in good to excellent yields. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Electrokinetic trapping using titania nanoporous membranes fabricated using sol–gel chemistry on microfluidic devices
Authors: Hoeman Kurt W. , Lange Jeffrey J. , Roman Gregory T. , Higgins Daniel A. , Culbertson Christopher T. 
Published: August 2009

AbstractWe have developed a new method for analyte preconcentration on a microfluidic device using a porous membrane fabricated via sol–gel chemistry. These porous membranes were fabricated within the channels of glass microfluidic devices exploiting laminar flow to bring an alcoholic sol–gel precursor (titanium isopropoxide in 2‐propanol) into contact with an alcohol–water solution at a channel cross intersection. These two streams reacted at the fluidic interface to form a porous titania membrane. The thickness of the membrane could be altered by changing the [H2O]. Analyte concentration was accomplished by applying a voltage across the titania membrane. The level of analyte enrichment was monitored, and enrichment factors of above 4000 in 400 s were obtained for 2,7‐dichlorofluorescein.
Design, fabrication and characterization of nano‐filters in silicon microfluidic channels based on MEMS technology
Authors: Chen Xing , Cui Dafu , Chen Jian 
Published: August 2009

AbstractSince most clinical assays are performed on cell‐free serum or plasma, micro‐analytical systems for blood tests require integrated on‐chip microfluidics for the isolation of plasma or serum from crude blood samples. In this paper, we present a crossflow filtration method using novel silicon nano‐filters for plasma separation. The microfluidic chip is made of a silicon substrate containing micropillar arrays, feed channels, side channels and nano‐gap structures, sealed with a PDMS‐glass compound cover. The design of the silicon filtration structures were optimized using numerical analysis and the optimal MEMS fabrication procedures were obtained. The filtration structures including nano‐filters were characterized using SEM and subsequently used to isolate plasma from whole blood in a continuous manner. Compared with micro‐gap structures in silicon microfluidic channels, the nano‐gap structures have been used to separate plasma from whole blood samples with higher selectivity, where a maximum plasma selectivity of 97.7% has been obtained. Common problems of clogging and jamming in filtration applications have seldom been noticed in our device. The presented microfluidic filtration device for plasma isolation could be integrated into μTAS for point‐of‐care diagnostics in the near future.
Exceeding 20 000‐fold concentration of protein by the on‐line isotachophoresis concentration in poly(methyl methacrylate) microchip
Authors: Wang Jun , Zhang Yong , Mohamadi Mohamad Reza , Kaji Noritada , Tokeshi Manabu , Baba Yoshinobu 
Published: August 2009

AbstractIn this research, a simple on‐line microchip gel electrophoresis with ITP was applied for the concentration and separation of BSA and its immunoassay complex with mAb in a single cross form PMMA microchip. We investigated the ITP concentration effect in PMMA MCE using combination of leading electrolytes, terminating electrolytes and other factors. We realized an ITP‐based concentration and separation of BSA and its immunoassay complexes in standard cross‐channel microchip gel electrophoresis, which exceeded 2000‐fold concentration of BSA immunocomplex using Tris‐H3PO4 as a leading electrolyte and Tris‐γ‐amino butyric acid as a terminating electrolyte. In addition, we also realized concentration of BSA sample in water, which was more than 20 000‐fold and was the result of the concentration effect from combining ITP and the sample stacking techniques.
A microfabricated CE chip for DNA pre‐concentration and separation utilizing a normally closed valve
Authors: Kuo Chen‐Hua , Wang Jung‐Hao , Lee Gwo‐Bin 
Published: August 2009

AbstractA simple, sequential DNA pre‐concentration and separation method by using a micro‐CE chip integrated with a normally closed valve, which is activated by pneumatic suction, has been developed. The CE chip is fabricated using PDMS. A surface treatment technique for coating a polymer bilayer with an anionic charge is applied to modify the surface of the microchannel. A normally closed valve with anionic surface charges forms a nanoscale channel that only allows the passage of electric current but traps the DNA samples so that they are pre‐concentrated. After the pre‐concentration step, a pneumatic suction force is applied to the normally closed valve. This presses down the valve membrane, which reconnects the channels. The DNA samples are then moved into a separation channel for further separation and analysis. Successful DNA pre‐concentration and separation has been achieved. Fluorescent intensity at the pre‐concentration area is increased by approximately 3570 times within 1.9 min of operation. The signals from the separation of ϕX174 DNA/HaeIII markers are enhanced approximately 41 times after 100 s of pre‐concentration time, as compared with the results using a traditional cross‐shaped micro‐CE chip. These results clearly demonstrate that successful DNA pre‐concentration for signal enhancement and separation analysis can be performed by using this new micro‐CE chip.