bluuebunny/crossref_metadata_2025_split huggingface dataset:
The use of virtual nominal groups in healthcare research: An extended scoping review
Authors: Lee Seung Ho , ten Cate Olle , Gottlieb Michael , Horsley Tanya , Shea Beverley , Fournier Karine , Tran Christopher , Chan Teresa , Wood Timothy J. , Humphrey-Murto Susan 
Published: June 2024

Introduction
The Nominal Group Technique (NGT) is a consensus group method used to synthesize expert opinions. Given the global shift to virtual meetings, the extent to which researchers leveraged virtual platforms is unclear. This scoping review explores the use of the vNGT in healthcare research during the COVID-19 pandemic.

Methods
Following the Arksey and O’Malley’s framework, eight cross-disciplinary databases were searched (January 2020-July 2022). Research articles that reported all four vNGT stages (idea generation, round robin sharing, clarification, voting) were included. Media Synchronicity Theory informed analysis. Corresponding authors were surveyed for additional information.

Results
Of 2,589 citations, 32 references were included. Articles covered healthcare (27/32) and healthcare education (4/32). Platforms used most were Zoom, MS Teams and GoTo but was not reported in 44% of studies. Only 22% commented on the benefits/challenges of moving the NGT virtually. Among authors who responded to our survey (16/32), 80% felt that the vNGT was comparable or superior.

Conclusions
The vNGT provides several advantages such as the inclusion of geographically dispersed participants, scheduling flexibility and cost savings. It is a promising alternative to the traditional in-person meeting, but researchers should carefully describe modifications, potential limitations, and impact on results.
Exploring the experiences, priorities and preferences of people living with Parkinson’s on exercise and physical activity promotion in the UK
Authors: Agley Ledia , Hartley Peter , Lafortune Louise 
Published: June 2024

Background
People with Parkinson’s (PwP) want access to timely, relevant, and specific exercise and physical activity (PA) information to enable them to manage their symptoms and maintain wellbeing and quality of life. Research that promotes exercise in this population group is limited. Little is also known about the clinical practice around PA promotion in this population, especially around the time of diagnosis.

Objective
To explore the experiences, preferences, and priorities of PwP around exercise and PA promotion and assess their knowledge on these topics.

Methods
A cross-sectional online survey for PwP in the United Kingdom was conducted from July to December 2021.

Results
430 participants started the survey and 405 completed it. Participants had a mean age of 65.1 (±9.2) and had been living with Parkinson’s for a varying time (up to 2 years = 38%, up to 6 years = 39% and for 7 or more years = 23%). Most participants reported they had not received an education (68%; n = 276) or exercise intervention (54%; n = 217) as part of their routine management by the National Health Service (NHS) since diagnosis and had sought services privately. Knowledge of the overall benefits of exercise was good, however participants lacked specific knowledge on the impact of Parkinson’s Disease (PD) on posture, falls and muscle strength. 90% of participants reported they would participate in an exercise and PA education interventions.

Conclusions
PwP want exercise and PA education interventions that provide knowledge, skills and access to opportunities that enable participation. For the majority, these interventions have not been provided as part of their routine care pathway. To align with the priorities and preferences of PwP, interventions should be offered around the time of diagnosis, include content that is relevant and specific to how exercise and PA can mitigate symptoms of PD and should be delivered in person or online in a group setting.
Factors in COVID-19 vaccine uptake in five racial/ethnic Colorado communities: A report from the Colorado CEAL project
Authors: Brewer Sarah E. , Bertin Kaitlyn B. , Suresh Krithika , LoudHawk-Hedgepeth Crystal , Tamez Montelle , Reno Jenna E. , Kwan Bethany M. , Nease Donald E. 
Published: June 2024

Purpose
To understand motivators, concerns, and factors associated with COVID-19 vaccine initiation for adults in five racial/ethnic communities across Colorado.

Methods
Community-based data collectors surveyed participants from five Colorado communities (urban and rural Latina/o/x, urban Black, rural African American immigrant, and urban American Indian) about vaccine attitudes, intentions, and uptake from September to December 2021. Bivariate and multivariable logistic regression models were used to examine factors associated with the primary outcome of COVID-19 vaccine “initiation.”

Results
Most participants (71.1%) reported having initiated COVID-19 vaccination; vaccine series completion was 65.1%. Both motivators and concerns about COVID-19 vaccines were prevalent. Vaccine hesitancy (OR: 0.41, 95% CI:0.32–0.53; p < .001) and low perceptions of COVID-19 vaccination social norms (OR: 0.48, 95% CI:0.27–0.84; p = .01) were associated with vaccine initiation.

Conclusion
Despite the limitation of a moderate sample size, our findings support the need for further interventions to increase vaccination against COVID-19 by reducing vaccine hesitancy and improving perceived social norms of vaccination in underserved Colorado communities.

Implications
To improve trust in vaccines and promote vaccine uptake, community messaging should be tailored to vaccination motivators and concerns and demonstrate COVID-19 vaccination as the community default.
The prevalence of mental health and addiction concerns and factors associated with depression and anxiety during the COVID-19 pandemic in Ontario, Canada: A cross-sectional study
Authors: Chang Oswin , Levitt Anthony , Khalid Maida , Kodeeswaran Sugy , Markoulakis Roula 
Published: June 2024

Objective
Higher than expected rates of mental health and/or addiction (MHA) concerns have been documented since the onset of the COVID-19 pandemic. A more up-to-date prevalence of MHA outcomes and the factors associated with the occurrence of MHA concerns remains unclear. This study examined the prevalence of MHA outcomes and factors associated with screening positive for symptoms of depression only, anxiety only, and both depression and anxiety two years into the COVID-19 pandemic in Ontario, Canada.

Method
Ontario adults ≥18 years of age (n = 5000) reported on the presence of symptoms associated with depression, anxiety, and substance use between January and March 2022. Data were also collected on pandemic-related health variables, including COVID-19 infection fear, changes in socioeconomic status and mental health since pandemic onset, satisfaction with social supports, and MHA service needs.

Results
The prevalence of positive screening for depressive or anxiety symptoms only was 8% and 11%, respectively, while 36% screened positive for both. Moderate/high risk levels of substance use were found in 20% of participants for tobacco and 17% for both alcohol and cannabis. Moderate/high risk levels of alcohol use and certain pandemic-related factors (negative change in mental health, unmet MHA service needs) were associated with positive screening for symptoms of depression only, anxiety only, and both depression and anxiety. Satisfaction with social supports was associated with lower likelihoods of being in the depression only and both depression and anxiety groups, and non-White ethnicity was associated with depression only.

Conclusions
There was a continued burden of MHA issues two years into the pandemic. These results underscore the ongoing need for timely and accessible MHA services.
Gender Trends in Authorship of Gastroenterology Randomized Controlled Trial Literature
Authors: Liu Crystal S. , Cromarty Taylor J. , Lin Zhao X. , Goodman Karen J. , Kroeker Karen I. 
Published: June 2024

INTRODUCTION:
We describe female authorship trends in gastroenterology (GI) randomized controlled trial literature as a novel focus on gender bias in academic GI.

METHODS:
Using a systematic PubMed search, we extracted GI randomized controlled trial reports published from 2011 to 2022. We describe time trends in proportions of females among first and last authors overall and within GI subspecialties and high-impact journals.

RESULTS:
The proportion of females increased from 25.4% to 36.8% and from 14.3% to 24.8% among first and last authors, respectively. Smaller increases in female authorship occurred in most subgroups, although there were proportionately fewer females among authors in high-impact journals and advanced therapeutic endoscopy publications.

DISCUSSION:
Over the past decade, female authorship in GI RCT reports has increased. However, female representation, particularly among senior authors and in high-impact journals, remains significantly lower. Despite recent improvements, female still constitutes a minority of the authors of original GI RCTs.
MAPEAMENTO DE SUSCETIBILIDADE ÀS INUNDAÇÕES COM BASE NA ANÁLISE MULTICRITÉRIO (AHP): ESTUDO DE CASO DO DISTRITO DE CHÓKWE, EM MOÇAMBIQUE
Authors: Chicombo Tomé Francisco , Moreira Alecir Antônio Maciel 
Published: June 2024

Este estudo procurou identificar os níveis de suscetibilidade às inundações no distrito de Chókwe (Moçambique), em um contexto de aumento de eventos extremos derivados das mudanças do clima. O Chókwe está localizado numa planície de inundação da bacia hidrográfica do rio Limpopo. Para a elaboração dos mapas foram aplicados pesos conforme a metodologia Analytical Hierarchy Process (AHP), proposta por Saaty na década de 1970. A elaboração do mapa foi realizada usando-se o ArgGis 10.4.1. A altitude foi o fator de maior influência. Outros fatores que contribuíram de forma significativa para a formação da suscetibilidade nessas áreas foram: a proximidade de canais de drenagem e o índice topográfico de umidade.
Scalar curvature along Ebin geodesics
Authors: Böhm Christoph , Buttsworth Timothy , Clarke Brian 
Published: June 2024

Abstract
Let 𝑀 be a smooth, compact manifold and let

N
μ

\mathcal{N}_{\mu}

denote the set of Riemannian metrics on 𝑀 with smooth volume density 𝜇.
For

g
0

∈

N
μ

g_{0}\in{\mathcal{N}_{\mu}}

, we show that if

dim

(
M
)

≥
5

\dim(M)\geq 5

, then there exists an open and dense subset

Y

g
0

⊂

T

g
0

⁢

N
μ

{\mathcal{Y}_{g_{0}}}\subset T_{g_{0}}{\mathcal{N}_{\mu}}

(in the

C
∞

C^{\infty}

topology) so that, for each

h
∈

Y

g
0

h\in{\mathcal{Y}_{g_{0}}}

, the

(

N
μ

,

L
2

)

({\mathcal{N}_{\mu}},L^{2})

Ebin geodesic

γ
h

⁢

(
t
)

\gamma_{h}(t)

with

γ
h

⁢

(
0
)

=

g
0

\gamma_{h}(0)=g_{0}

and

γ
h
′

⁢

(
0
)

=
h

\gamma_{h}^{\prime}(0)=h

satisfies

lim

t
→
∞

R
⁢

(

γ
h

⁢

(
t
)

)

=

−
∞

\lim_{t\to\infty}R(\gamma_{h}(t))=-\infty

, uniformly, where

R
:

N
μ

→

C
∞

⁢

(
M
)

R\colon\mathcal{N}_{\mu}\to C^{\infty}(M)

is the scalar curvature.
Hybrid optical-electronic compensation of fiber nonlinearity for long-haul coherent optical transmission
Authors: Tong Xiaogang , Huang Wei , Cao Weiwei , Zhang Junsheng , Zhang Xiaojuan 
Published: June 2024

Abstract
From the concepts of the dispersion-folded digital backward propagation (DBP) and optical phase conjugation (OPC), a hybrid optical-electronic nonlinearity-compensation scheme is proposed to enhance the system performance of the dispersion-managed transmission. The computational complexity of the proposed scheme, compared with that of the conventional DBP method, is reduced significantly while the performance penalty is negligible. The compensation efficiency of the proposed scheme has been validated in a 5 (and 9)-channel PM-16QAM system at 256 Gbit/s.
The role of antibodies in small fiber neuropathy: a review of currently available evidence
Authors: Morelli Luana , Serra Lucrezia , Ricciardiello Fortuna , Gligora Ilaria , Donadio Vincenzo , Caprini Marco , Liguori Rocco , Giannoccaro Maria Pia 
Published: June 2024

Abstract
Small fiber neuropathy (SFN) is a peripheral nerve condition affecting thin myelinated Aδ and unmyelinated C-fibers, characterized by severe neuropathic pain and other sensory and autonomic symptoms. A variety of medical disorders can cause SFN; however, more than 50% of cases are idiopathic (iSFN). Some investigations suggest an autoimmune etiology, backed by evidence of the efficacy of IVIG and plasma exchange. Several studies suggest that autoantibodies directed against nervous system antigens may play a role in the development of neuropathic pain. For instance, patients with CASPR2 and LGI1 antibodies often complain of pain, and in vitro and in vivo studies support their pathogenicity. Other antibodies have been associated with SFN, including those against TS-HDS, FGFR3, and Plexin-D1, and new potential targets have been proposed. Finally, a few studies reported the onset of SFN after COVID-19 infection and vaccination, investigating the presence of potential antibody targets. Despite these overall findings, the pathogenic role has been demonstrated only for some autoantibodies, and the association with specific clinical phenotypes or response to immunotherapy remains to be clarified. The purpose of this review is to summarise known autoantibody targets involved in neuropathic pain, putative attractive autoantibody targets in iSFN patients, their potential as biomarkers of response to immunotherapy and their role in the development of iSFN.
Kulturelle Ressourcen in spirituellen Krisen
Authors: Maidl Lydia 
Published: June 2024

Zusammenfassung
In allen Kulturen finden sich Erzählungen und Bilder, die in Krisensituationen Wegweisung geben wollen. Durch die Deutung im Rahmen der kulturellen Narrative werden die persönlichen und gesellschaftspolitischen Krisen in einen größeren Kontext gestellt: Menschen erleben sich eingebunden in Menschheitserfahrungen seit Jahrtausenden. Dies entlastet, schenkt Trost, gibt ein Gefühl von Zugehörigkeit. Die Hinweise auf Bewältigung, Rettung, Befreiung – häufig in religiösen Kontexten – geben Hoffnung für die eigene Situation. Wenn Menschen unserer Gesellschaft sich heute immer weniger religiös verortet fühlen, so gewinnen die Künste als Träger dieser kulturellen Ressourcen an Bedeutung.
Für unseren westlich-abendländischen Kulturkreis sind zentrale – nicht die einzigen – Orientierungsmarken die Bibel und die mit ihr verbundenen jüdisch-christlichen Auslegungstraditionen sowie die antiken Mythen. Der Künstler Erich Schickling (1924–2012) hat seine Erfahrungen im Kontext dieser Narrative gedeutet und ikonographisch zum Ausdruck gebracht. Es begegnen uns dabei die großen politischen Krisensituationen des 20. Jahrhunderts: Krieg, Vertreibung, Heimatverlust, Neuanfang, welche ihn existenziell betroffen haben, sowie Reflexe persönlicher Krisenerfahrungen. Im Beitrag wird an ausgewählten Bildern gezeigt, welche archetypischen Motive und Gestalten dem Künstler Orientierung gaben und wie er sie künstlerisch gestaltete. Die vorausgehende Einführung in das Verständnis von Archetypen und ihrer Bedeutung in Krisensituationen sowie die abschließenden Empfehlungen sind Impulse für die die Selbstfürsorge und Begleitung von Menschen in spirituellen Krisen.
The effect of curcumin on PI3K/Akt and AMPK pathways in insulin resistance induced by fructose
Authors: Kiren Gülce , Severcan Çınar , Severcan Suzan Muratoğlu , Paşaoğlu Hatice 
Published: June 2024

Abstract

Objectives
Excessive fructose consumption is recognized to elevate insulin resistance in animals and humans. In our study, we aimed to assess the possible consequences of curcumin (curc) treatment applied to rat models of fructose-induced insulin resistance on adenosine monophosphate-activated protein kinase (AMPK) and phosphatidylinositol-3 kinase (PI3K)/protein kinase B (Akt) pathways in skeletal muscle and adipose tissue.

Methods
We established four distinct rat groups: corn oil (negative control group), 20 % fructose (positive control group), 20 % fructose and 100 mg/kg curc (100 mg/kg curc group), and 20 % fructose and 200 mg/kg curc (200 mg/kg curc group). The ELISA method was used to determine serum insulin levels, an auto-analyzer was used to measure serum glucose levels, and homeostatic model assessment of insulin resistance (HOMA-IR) values were calculated. In the rat’s skeletal muscle and adipose tissues, the ELISA method was used to determine the following parameters: insulin receptor substrate-1 (IRS-1), phosphorylated insulin receptor substrate-1 (p-IRS-1), PI3K, phosphatidylinositol 3,4,5-trisphosphate (PIP3), phosphoinositide-dependent kinases (PDK-1), phosphorylated Akt (p-Akt), AMPK and glucose transporter type 4 (GLUT4) levels.

Results
The positive control group exhibited a significant increase in serum glucose, insulin, and HOMA-IR levels, confirming the establishment of the insulin resistance model. In the curcumin dose groups, these values significantly decreased. Additionally, compared to the positive control groups, curcumin dose groups demonstrated a significant increase in the parameters of the Akt/PI3K pathway, AMPK activation, and GLUT4 levels in skeletal muscle and adipose tissues.

Conclusions
We observed that curcumin demonstrates potential ameliorative effects on the insulin signaling pathway through PI3K/Akt and AMPK pathways.
In vitro antibacterial and antioxidant activity of flavonoids from the roots of Tephrosia vogelii: a combined experimental and computational study
Authors: Abera Bihon , Melaku Yadessa , Shenkute Kebede , Degu Sileshi , Abebe Abiy , Gemechu Worku , Endale Milkyas , Woldemariam Messay , Hunsen Mo , Hussein Ahmed A. , Dekebo Aman 
Published: June 2024

Abstract

Tephrosia vogelii is a traditional medicinal plant used to treat hypertension, diarrhea and urinary disorders. Silica gel chromatographic separation of CH2Cl2/MeOH (1:1) roots extract of T. vogelii afforded seven compounds namely; β-sitosterol (1a), stigmasterol (1b), 6a, 12a-dehydro-deguelin (2), tephrosin (3), maackiain (4), obovatin (5) and 6-oxo, 6a, 12a-dehydro-deguelin (6). GC-MS analysis of essential oils from the root of T. vogelii displayed a total of 17 compounds of which cis-nerolidol (41.7 %) and cadinol (19.7 %) were the major constituents. CH2Cl2/MeOH (1:1) extract, MeOH extract, maackiain (4) and obovatin (5) showed moderate inhibitory activity against Pseudomonas aeruginosa with MIC value of 0.5, 0.66, 0.83 and 0.83 mg/mL, respectively, compared to ciprofloxacin (MIC of 0.078 μg/mL). 6a, 12a-dihydro-deguelin (2), and 6-oxo, 6a, 12a-dehydro-deguelin (6) displayed significant activity against S. epidermis with MIC values of 0.66 mg/mL. Tephrosin (3) and maackiain (4) also showed moderate antibacterial activity against Staphylococcus aureus and Proteus mirabilis with MIC values of 0.83 and 0.5 mg/mL, respectively, compared to ciprofloxacin (0.312 μg/mL). The radical scavenging activity results indicated that tephrosin (3), obovatin (5) and 6-oxo, 6a, 12a-dehydro-deguelin (6) showed potent DPPH scavenging activity with IC50 values of 10.97, 10.43 and 10.73 μg/mL, respectively, compared to ascorbic acid (IC50 of 5.83 μg/mL). The docking prediction results revealed that 6a, 12a-dehydro-deguelin (2) displayed the best binding energy of −8.1 kcal/mol towards pyruvate kinase of S. aureus (PDB ID: 3T07) and −7.9 kcal/mol towards P. mirabilis urease (PDB ID: 1E9Y) and DNA gyrase B of Escherichia coli (PDB: 4F86) receptors compared to ciprofloxacin (−7.2 to −8.0 kcal/mol). Maackiain (4) and obovatin (5) displayed the minimum binding energy of −7.9 and −8.2 kcal/mol towards the LasR protein of P. aeruginosa (PDB: ID 2UV) and S. epidermidis FtsZ (PDB: ID 4M8I), respectively. The SwissADME drug-likeness and Pro Tox II toxicity prediction results indicated that compounds (2–6) obeyed Lipinski’s rule of five with 0 violations and none of them were found to be hepatotoxic, mutagenic, and cytotoxic, respectively. The in vitro assessment results supported by the in silico analysis revealed that crude extracts and isolated compounds showed promising antibacterial and antioxidant activity, which proves the therapeutic potential of the roots of T. vogelii.
Satisfaction level and correlation between performance and self-evaluation of physical therapy students in an objective structured clinical examination (OSCE) designed to assess clinical reasoning
Authors: Figueroa-González Paola , Figueroa-Arce Nicole , Gómez-Miranda Luis , Gutiérrez-Arias Ruvistay , Contreras-Pizarro Viviana 
Published: June 2024

Introduction: The Objective Structured Clinical Evaluation (OSCE) is an instrument that allows evaluating clinical reasoning among physical therapy students, considering that knowing the correlation between their performance and their self-evaluation, as well as their level of satisfaction with this instrument, is essential.
Objectives: To determine the correlation between performance and self-evaluation (perceived performance) of physical therapy students in an OSCE designed to assess clinical reasoning, and to evaluate their level of satisfaction with this instrument.
Materials and methods: Analytical cross-sectional study conducted in 159 physical therapy students from a university in Chile who participated in an 11-station OSCE. Performance checklists and answer sheets were used for performance evaluation (passing score: 70% of the maximum score per station and in the OSCE). Two perception surveys were also used, one for self-evaluation of performance (for each station) and another to determine the students’ level of satisfaction with the OSCE. The correlation between performance in the OSCE (overall score, score by station, and score by type of station) and perceived performance was determined using the Spearman’s correlation coefficient.
Results: The level of satisfaction with the OSCE was high in 57.23% of the students. The correlation between the total score in the OSCE and perceived performance was significant, but weak (Rho=0.31; p<0.001). In students with a low satisfaction level with the OSCE, the correlation between performance and perceived performance was not significant (Rho=0.15; p=0.23), while in those with high satisfaction level it was significant and moderate (Rho=0.48; p<0.001).
Conclusions: Most students reported a high level of satisfaction with the OSCE. However, in most stations, the correlation between observed and perceived performance was weak and very weak.