bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phenotype of five cases of prenatally diagnosed campomelic dysplasia harboring novel mutations of the SOX9 gene
Authors: Gentilin B. , Forzano F. , Bedeschi M. F. , Rizzuti T. , Faravelli F. , Izzi C. , Lituania M. , Rodriguez‐Perez C. , Bondioni M. P. , Savoldi G. , Grosso E. , Botta G. , Viora E. , Baffico A. M. , Lalatta F. 
Published: September 2010

AbstractObjectivesCampomelic dysplasia is a rare congenital skeletal disorder characterized by bowing of the long bones and a variety of other skeletal and extraskeletal defects, many of which can now be identified prenatally using advanced ultrasound equipment. The disorder is caused by mutations in SRY‐box 9 (SOX9), a gene that is abundantly expressed in chondrocytes as well as in other tissues. However, the correlation between genotype and phenotype is still unclear. We report five cases of prenatally detected campomelic dysplasia in which the diagnosis was confirmed by molecular analysis.MethodsUltrasound examinations were performed between 12 and 32 weeks. Standard fetal biometric measurements were obtained. Fetal sex was determined sonographically and confirmed by chromosomal analysis. Genomic DNA was obtained in four cases before termination of pregnancy from chorionic villi or amniocytes and in one case postnatally from peripheral blood.ResultsSkeletal dysplasia, most often limb shortening and bowed femora, was observed in one case in the first trimester, in three cases in the second trimester and in one case, presenting late for antenatal care, in the third trimester. Four of the pregnancies were terminated and one was carried to term. Postmortem/postnatal physical and radiographic examinations confirmed the presence of anomalies characteristic of campomelic dysplasia. A de novo mutation in the SOX9 gene was detected in all four cases that underwent termination. The father of the proband in the case that went to term was a carrier of a somatic mosaic mutation without clinical or radiographic signs of campomelic dysplasia.ConclusionsIt is likely that the integrated expertise of ultrasonographers, obstetricians, pediatricians and clinical geneticists will markedly improve the likelihood of accurate prenatal clinical diagnoses of campomelic dysplasia. This will, in turn, encourage more specific molecular testing and facilitate comprehensive genetic counseling. Copyright © 2010 ISUOG. Published by John Wiley & Sons, Ltd.
Queue length aware power control for delay‐ constrained communication over fading channels
Authors: Li Xiaochen , Dong Xihua , Wu Dapeng 
Published: September 2010

AbstractIn this paper, we study efficient power control schemes for delay sensitive communication over fading channels. Our objective is to find a power control law that optimizes the link layer performance, specifically, minimizes the packet drop probability, subject to a long‐term average power constraint. We assume the buffer at the transmitter is finite; hence packet drop happens when the buffer is full. The fading channel under our study has a continuous state, e.g., Rayleigh fading. Since the channel state space is continuous, dynamic programming is not applicable for power control. In this paper, we propose a sub‐optimal power control law based on a parametric approach. The proposed power control scheme tries to minimize the packet drop probability by considering the queue length, i.e., reducing the probability of those queue‐length states that will cause full buffer. Simulation results show that our proposed power control scheme reduces the packet drop probability by one or two orders of magnitude, compared to the time domain water filling (TDWF) and the truncated channel inversion (TCI) power control. Copyright © 2010 John Wiley & Sons, Ltd.
Two cases of ectopic ovary and one case of potential ectopic ovary
Authors: Nishio Eiji , Hirota Yutaka , Yasue Akira , Nishizawa Haruki , Tsukada Kazuhiko , Udagawa Yasuhiro 
Published: September 2010

AbstractEctopic ovary is a rare gynecologic entity. A variety of synonymous terms such as ectopic ovary, supernumerary ovary, accessory ovary, and autoamputation of the ovary have been used to describe this condition. The etiology for ectopic ovary has not been elucidated, but several mechanisms have been proposed. They are categorized as either congenital (embryologically derived) or acquired. This report presents two cases of ectopic ovary resulting from different causes and one case of potential ectopic ovary.
Brazil and ‘Latin America’
Authors: BETHELL LESLIE 
Published: September 2010

AbstractThis essay, part history of ideas and part history of international relations, examines Brazil's relationship with Latin America in historical perspective. For more than a century after independence, neither Spanish American intellectuals nor Spanish American governments considered Brazil part of ‘América Latina’. For their part, Brazilian intellectuals and Brazilian governments only had eyes for Europe and increasingly, after 1889, the United States, except for a strong interest in the Río de la Plata. When, especially during the Cold War, the United States, and by extension the rest of the world, began to regard and treat Brazil as part of ‘Latin America’, Brazilian governments and Brazilian intellectuals, apart from some on the Left, still did not think of Brazil as an integral part of the region. Since the end of the Cold War, however, Brazil has for the first time pursued a policy of engagement with its neighbours – in South America.
Sulfide induces phosphate release from polyphosphate in cultures of a marine Beggiatoa strain
Authors: Brock Jörg , Schulz-Vogt Heide N 
Published: September 2010

Abstract
Sulfur bacteria such as Beggiatoa or Thiomargarita have a particularly high capacity for storage because of their large size. In addition to sulfur and nitrate, these bacteria also store phosphorus in the form of polyphosphate. Thiomargarita namibiensis has been shown to release phosphate from internally stored polyphosphate in pulses creating steep peaks of phosphate in the sediment and thereby inducing the precipitation of phosphorus-rich minerals. Large sulfur bacteria populate sediments at the sites of recent phosphorite formation and are found as fossils in ancient phosphorite deposits. Therefore, it can be assumed that this physiology contributes to the removal of bioavailable phosphorus from the marine system and thus is important for the global phosphorus cycle. We investigated under defined laboratory conditions which parameters stimulate the decomposition of polyphosphate and the release of phosphate in a marine Beggiatoa strain. Initially, we tested phosphate release in response to anoxia and high concentrations of acetate, because acetate is described as the relevant stimulus for phosphate release in activated sludge. To our surprise, the Beggiatoa strain did not release phosphate in response to this treatment. Instead, we could clearly show that increasing sulfide concentrations and anoxia resulted in a decomposition of polyphosphate. This physiological reaction is a yet unknown mode of bacterial polyphosphate usage and provides a new explanation for high phosphate concentrations in sulfidic marine sediments.
Plasma internal inductance dynamics in a tokamak
Authors: Romero J.A. 
Published: September 2010

A lumped parameter model for tokamak plasma current and inductance time evolution as a function of plasma resistance, non-inductive current drive sources and boundary voltage or poloidal field coil current drive is presented. The model includes a novel formulation leading to exact equations for internal inductance and plasma current dynamics. Having in mind its application in a tokamak inductive control system, the model is expressed in state space form, the preferred choice for the design of control systems using modern control systems theory. The choice of system states allows many interesting physical quantities such as plasma current, inductance, magnetic energy, and resistive and inductive fluxes be made available as output equations.
The model is derived from energy conservation theorem, and flux balance theorems, together with a first order approximation for flux diffusion dynamics. The validity of this approximation has been checked using experimental data from JET showing an excellent agreement.
MORPHEUS’ MOLECULE1 Is Required to Prevent Aberrant RNA Transcriptional Read-Through in Arabidopsis
Authors: Zhou Yue , Zhang Jun , Lin Huixin , Guo Guangqin , Guo Yan 
Published: September 2010

Abstract
Several pathways function to remove aberrant mRNA in eukaryotic cells; however, the exact mechanisms underlying the restriction of aberrant mRNA transcription are poorly understood. In this study, we found that MORPHEUS’ MOLECULE1 (MOM1) is a key component of this regulatory machinery. The Arabidopsis (Arabidopsis thaliana) mom1-44 mutation was identified by luciferase imaging in transgenic plants harboring a cauliflower mosaic virus 35S promoter-LUCIFERASE transgene lacking the 3′-untranslated region. In the mom1-44 mutant, transcriptional read-though occurred in genes with an aberrant RNA structure. Analysis of an RNA-dependent RNA polymerase2 mom1 double mutant revealed that the RNA-directed DNA methylation pathway is not involved in this regulatory process. Moreover, the prevention of aberrant mRNA transcriptional read-through by MOM1 is gene locus and transgene copy number independent.
Auxin Carriers Localization Drives Auxin Accumulation in Plant Cells Infected byFrankiainCasuarina glaucaActinorhizal Nodules
Authors: Perrine-Walker Francine , Doumas Patrick , Lucas Mikael , Vaissayre Virginie , Beauchemin Nicholas J. , Band Leah R. , Chopard Jérome , Crabos Amandine , Conejero Geneviève , Péret Benjamin , King John R. , Verdeil Jean-Luc , Hocher Valérie , Franche Claudine , Bennett Malcolm J. , Tisa Louis S. , Laplaze Laurent 
Published: September 2010

AbstractActinorhizal symbioses are mutualistic interactions between plants and the soil bacteria Frankia that lead to the formation of nitrogen-fixing root nodules. Little is known about the signaling mechanisms controlling the different steps of the establishment of the symbiosis. The plant hormone auxin has been suggested to play a role. Here we report that auxin accumulates within Frankia-infected cells in actinorhizal nodules of Casuarina glauca. Using a combination of computational modeling and experimental approaches, we establish that this localized auxin accumulation is driven by the cell-specific expression of auxin transporters and by Frankia auxin biosynthesis in planta. Our results indicate that the plant actively restricts auxin accumulation to Frankia-infected cells during the symbiotic interaction.
Diltiazem‐associated photodistributed hyperpigmentation: Report of two Japanese cases and published work review
Authors: KUBO Yoshiaki , FUKUMOTO Daisuke , ISHIGAMI Takeshi , HIDA Yasutoshi , ARASE Seiji 
Published: September 2010

AbstractScherschum et al. proposed diltiazem‐associated photodistributed hyperpigmentation as a novel type of drug‐induced photosensitive lichenoid eruption. The characteristic clinical features were slate‐gray reticulated hyperpigmentation on sun‐exposed areas, while lichenoid dermatitis with prominent pigmentary incontinence was noted histologically. Although the clinical and histological features were similar to those of lichen planus pigmentosus, the histological features did not show either compact hyperkeratosis or wedge‐shaped hypergranulosis, which are typical histological features of lichen planus. We describe two Japanese cases of diltiazem‐associated photodistributed hyperpigmentation, who were successfully treated with topical tacrolimus, and review the published work.
Erythema nodosum associated with Yersinia enterocolitica infection
Authors: YOTSU Rie , MII Sumiyuki , HAYASHI Rika , HARADA Harumi , FURUKAWA Keiichi , ETO Hikaru 
Published: September 2010

AbstractWe report a 74‐year‐old woman who presented to hospital with fever, vomiting, diarrhea, and 2 weeks later developed erythema nodosum (EN) on the legs, and was diagnosed with Yersinia enterocolitica infection based on her clinical course and microbiological examination of the stool. She also had a complication of pancreatitis, which made the diagnosis challenging. We should suspect infection by Y. enterocolitica when diagnosing cases of EN with gastrointestinal symptoms. We assume EN is likely to appear 2 weeks after the onset of gastrointestinal symptoms from our case and other case reports.
Lupus pernio with multiple bone cysts in the fingers
Authors: NAGAI Yayoi , IGARASHI Naoya , ISHIKAWA Osamu 
Published: September 2010

AbstractA 32‐year‐old Japanese man presented with a 3‐year history of purple reddish, and painful swelling of his fingers along with indurated erythema on his nose and ears. He was diagnosed as having sarcoidosis 8 years prior because of uveitis and bilateral hilar lymphadenopathy. X‐rays of the hands revealed multiple cystic lesions in the phalanges. Histological examination of the ear revealed epithelioid cell granulomas in the dermis. Oral prednisolone 20 mg/day improved his finger swelling and pain; however, his finger deformities and erythema remain unchanged. Bone involvement is sometimes seen in sarcoidosis and the hands are the most frequently affected areas. The frequency of bone involvement is higher in lupus pernio in comparison with other types of skin sarcoidosis. Systemic corticosteroids could be the first choice of treatment to relieve the symptoms.
Original article: Gel properties of red tilapia surimi: effects of setting condition, fish freshness and frozen storage
Authors: Mahawanich Thanachan , Lekhavichitr Jirachai , Duangmal Kiattisak 
Published: September 2010

SummaryThis study aimed to determine effects of setting condition, fish freshness and storage time of frozen surimi on properties of red tilapia surimi gel. To investigate the effect of setting condition, a combination of eight setting temperatures (35–70 °C) and four setting times (30–120 min) was used. Maximum breaking force, deformation and gel strength were obtained after the gel had been set at 40 °C for 90 or 120 min. Setting at 65 °C resulted in the lowest obtained gel strength, because of proteolytic degradation of myosin heavy chain. Increasing storage time of raw fish material in ice caused a significant decrease in gel strength of the resultant surimi gel (P < 0.05). Gels produced from surimi kept in frozen storage for up to 9 months also exhibited reduced gel strength, with a concomitant increase in the expressible drip, with increasing storage time (P < 0.05).
Original article: Characterisation of water species revealed in the drying operation of Todarodes pacificus Steenstrup using water proton NMR analysis
Authors: Konishi Yasuyuki , Kobayashi Masayoshi , Miura Kou‐ichi 
Published: September 2010

SummaryFor the discrimination of water molecules during the squid‐drying process, the water distribution was characterised by water proton NMR and moisture diffusivity (De) analysis methods as a function of the water content (W0). The proton NMR spectrum showed three peaks indicating three different species (species‐A, ‐B, and ‐C) distributed in the squid muscle, each of which had a characteristic behaviour of the relaxation time (T2) as a function of the W0. The 1/T2 of species‐A was drastically varied at W0 = 120%‐d.b., indicating two further categories, i.e., species‐A1 and ‐A2. Species‐A1 is available at W0 > 120%‐d.b. and was characterised as having De = 5.1 × 10−10 m2 s−1, activation energy of moisture diffusivity (ED) = 17 kJ mol−1, and relaxation rate 1/T2 = 74 s−1, as evaluated by the proton NMR spectrum without depending on W0. Species‐A2 is available at W0 < 120%‐d.b., indicating a distribution of De = 4.8 × 10−10–1.7 × 10−10 m2 s−1, ED = 25–35 kJ mol−1 and 1/T2 = 1.8 × 103–1.5 × 102 s−1 with increasing W0. Species‐A1 and ‐A2 were assigned as weakly restricted water and strongly restricted water, respectively.
Invited review: Modelling quality changes of fruits and vegetables during drying: a review
Authors: Devahastin Sakamon , Niamnuy Chalida 
Published: September 2010

SummaryFruits and vegetables have received much attention as these materials have been reported to contain various phytochemicals, which are claimed to exert many health benefits. When extraction of bioactive compounds cannot be performed on fresh fruits and vegetables, drying needs to be conducted to keep the materials for later use. Dried fruits and vegetables have also been regarded as alternative fat‐free snacks and received more attention from the food industry during the past decade. This implies that not only nutritional changes, but also other changes including physical and microstructural changes are of importance and need to be optimised, preferably through the use of various modelling approaches. The objective of this article is to provide a brief review of some advances in modelling quality changes of fruits and vegetables during drying. These include modelling of nutritional, colour and selected physical changes. Approaches to monitoring and modelling microstructural changes are also mentioned.
Original article: Effect of sucrose and glycerol mixtures in the osmotic solution on characteristics of osmotically dehydrated mandarin cv. (Sai‐Namphaung)
Authors: Pattanapa Kanitta , Therdthai Nantawan , Chantrapornchai Withida , Zhou Weibiao 
Published: September 2010

SummaryThis study investigated the effects of a series of osmotic solutions consisting of sucrose and glycerol on the quality of osmotically dehydrated mandarin, namely mandarin cv. (Sai‐Namphaung). Mandarin samples were peeled and osmotically dehydrated at 55 °C with agitation at 3.5776 × 10−1g in five osmotic solutions containing various mixtures of 60% sucrose and 60% glycerol (9:1, 8:2, 7:3, 6:4 and 5:5 w/w, respectively). The osmotically dehydrated mandarin was further dried using hot‐air drying at 70 °C for 360 min. Increasing the glycerol ratio in the mixtures significantly (P ≤ 0.05) increased water loss and solid gain during osmotic dehydration, and significantly (P ≤ 0.05) affected kinetic rate constants during drying. An increase in the glycerol ratio in the mixtures caused a significant decrease in the quality factors of hardness, moisture content, water activity and reducing sugar. However, the increase resulted in an increase in the darkness of the dried mandarin, compared with increasing the sucrose ratio in the mixtures (P ≤ 0.05). The increase had an insignificant (P > 0.05) effect on vitamin C content.
Original article: In vitro starch digestion and potassium release in sweet potato from Papua New Guinea†
Authors: Liu Yun , Sabboh Houda , Kirchhof Gunnar , Sopade Peter 
Published: September 2010

SummaryTwenty samples of sweet potato from Papua New Guinea, made up of cultivars 3‐mun, Carot kaukau, Wahgi besta, Nillgai, Baiyer kaukau, and 1‐mun from three provinces, three farmers, and three locations, were subjected to an in vitro starch digestion procedure. Digestion of starch was studied by glucometry, while potassium release was monitored using electrochemistry. The potassium content of the nondigested samples ranged from 4 to 17 mg g−1 dry solids, while the starch content was from 47 to 80 g per 100 g dry solids and independent of G × E effects. In vitro starch digestibility (2–75 g digested starch per 100 g dry starch) significantly (P < 0.05) varied with time in a nonlinear manner with biphasic digestograms. Potassium release was independent of time in in vitro gastric and pancreatic regions, but more potassium was released during pancreatic than gastric digestion. Results suggest differences in resistant starch and bioavailability of (micro)nutrients that could influence utilisation of sweet potato.
Original article: Super‐chilling maintains freshness of modified atmosphere‐packaged Lateolabrax japonicus
Authors: Liu Shu‐Lai , Lu Fei , Xu Xiao‐Bao , Ding Yu‐Ting 
Published: September 2010

SummaryThe effect of −1.5 °C brine super‐chilling on the quality of the modified atmosphere‐packaged Lateolabrax japonicus fish fillets was studied. The result showed that the total viable mesophilic count (TVC) and H2S‐producing bacterial count (HC) of samples were super‐chilled, and then modified atmosphere‐packaged (Sc + Map) were lower than that of Map (Samples were not super‐chilled but modified atmosphere packaged), and values of total volatile base nitrogen (TVB‐N), thiobarbituric acid (TBA), pH and myofibril fragmentation index (MFI) for Sc + Map increased more slowly than those for Map. Colour of skin and flesh of fish fillets was not affected by brine super‐chilling, except the whiteness of the skin of fish fillets. Sc + Map could extend the shelf life of fish fillets for 4 days longer than Map.
Original article: Innovation in fig syrup production process: a rheological approach
Authors: Gabriele Domenico , Migliori Massimo , De Cindio Bruno 
Published: September 2010

SummaryAn engineering approach, based on rheological characterisation, to the analysis of a food process for fruit syrup production is presented in this paper. The process has been investigated to analyse the effects of selected operating parameters on the product rheology to design materials having mechanical properties suitable for specific applications. Process conditions have been changed either adding alkaline salts, as pH modifiers to improve pectin extraction efficiency, or decreasing operative temperature, reducing thermal damage of the material. It has been found that alkaline salt addition yields structured products because of the improved efficiency of pectin extraction and to the enhancement of the gelation phenomena. Mild conditions during either extraction or concentration lead to a more structured syrup, whereas more drastic operations bring to liquid‐like products. The proposed approach, based on the analysis of rheological properties, may support the design of new products having controlled properties and may reduce the effect of raw material variability onto the product quality.
Stringent glycaemic control prolongs survival in diabetic patients with end‐stage renal disease on haemodialysis
Authors: SHIMA KENJI , KOMATSU MACHIKO , KAWAHARA KAZUHIKO , MINAGUCHI JUN , KAWASHIMA SHU 
Published: September 2010

ABSTRACTAim:  No suitable index or optimal target for diabetic control has been established for diabetic patients with end‐stage renal disease (ESRD) undergoing haemodialysis. To address these issues, the single‐centre observational study was conducted.Methods:  Two hundred and forty‐five diabetic ESRD patients (23.3% female; age at initiation of haemodialysis 61.7 ± 10.7 years) at start of haemodialysis between 1 January 1995 and 31 December 2004 were enrolled. Subjects were grouped according to glycaemic control level throughout the observational period as follows: mean postprandial plasma glucose (PPG) <8.9 mmol/L, 8.9 mmol/L ≤ PPG < 10.0 mmol/L, 10.0 mmol/L ≤ PPG < 11.1 mmol/L, 11.1 mmol/L ≤ PPG < 12.2 mmol/L and PPG ≥ 12.2 mmol/L; and HbA1c < 6.0%, 6.0–6.4%, 6.5–6.9% and ≥7.0%. Survival was then followed until 31 December 2005.Results:  Cumulative survival of groups of 10.0 mmol/L ≤ PPG < 11.1 mmol/L, 11.1 ≤ PPG < 12.2 and PPG ≥ 12.2 mmol/L was significantly lower than that for PPG < 8.9 mmol/L as determined by Kaplan–Meier estimation (P = 0.016, 0.009 and 0.031, respectively; log–rank test). In both uni‐ and multivariate Cox proportional hazard models, mortality hazard ratios were significantly higher for PPG ≥ 10.0 mmol/L than for PPG < 8.9 mmol/L (P = 0.002–0.021). Kaplan–Meier survival curves grouped by HbA1c levels showed no correlation between HbA1c and survival during the observational period. No significant difference in mortality hazard ratios was seen for any HbA1c groups evaluated by Cox proportional hazard model.Conclusion:  Intensive management of diabetic control at a stringent mean on‐study PPG < 10.0 mmol/L will improve the life expectancy in diabetic dialysis patients. However, no range of HbA1c values obtained in this study showed any clear difference in clinical outcomes.