bluuebunny/crossref_metadata_2025_split huggingface dataset:
Attitude to food supplement use: a survey promoted by the Italian Society of Pediatric Allergy and Immunology
Authors: Ciprandi Giorgio , Daglia Maria , Brindisi Giulia , Brunese Francesco Paolo , Dinardo Giulio , Gori Alessandra , Indolfi Cristiana , Naso Matteo , Tondina Enrico , Trincianti Chiara , Varricchio Attilio , Zicari Anna Maria , del Giudice Michele Miraglia , Drago Lorenzo 
Published: June 2024

AbstractFood supplements are defined as foodstuffs the purpose of which is to supplement the normal diet and which are concentrated sources of nutrients or other substances with a nutritional or physiological effect, often referred to as nutraceuticals, may exert benefit to the human body. Their use is increasing worldwide, including Europe and in Italy. However, some doctors are skeptical about their effectiveness and safety. This reluctance may depend on poor knowledge of the mechanisms of action and clinical evidence in literature. The Italian Society of Pediatric Allergy and Immunology (SIAIP) promoted the institution of an ad hoc Committee. The first initiative performed by this Committee was the administration of a questionnaire to the members of SIAIP.The results of this survey provided interesting results. Most pediatricians know the food supplement concept but frequently need help understanding the mechanisms of action. Most prescribe food supplements, mainly for preventing infections or enhancing immune defense. In addition, they prefer to use food supplements as cycles or add-on therapy. Finally, most participants like to attend events on this issue and contribute to new evidence through trials.In conclusion, this survey underscores the relevance of food supplement issues and attests to interest in this topic. However, there is a need to provide information and promote studies on this matter.
A 42-year-old woman with abnormal uterine bleeding—leiomyoma (AUB-L) reporting a hemoglobin of 1.6 g/dL: a case report
Authors: Qaadri Shamsa M. , Luthra Tavsimran S. , Budhu Kumarie , Sagi Or 
Published: June 2024

Abstract
Background
Abnormal uterine bleeding, formerly known as menometrorrhagia, is estimated to occur in up to one-third of women, commonly at menarche or perimenopause. Among many other causes, abnormal uterine bleeding is known to be caused by leiomyomas, and is itself a leading cause of severe iron deficiency and iron deficiency anemia in women. Rarely, abnormal uterine bleeding can lead to critically low hemoglobin values of less than 2 g/dL. We report here a case of a woman with abnormal uterine bleeding caused by leiomyomas presenting with severely low hemoglobin.

Case presentation
We report the case of a 42-year-old Asian American woman who presented to the emergency department with chronic abnormal uterine bleeding and symptoms of anemia, including multiple syncopal episodes and abnormally pale skin but otherwise alert and oriented. Laboratory tests found a record-low hemoglobin of 1.6 g/dL and hematocrit of 6%. Transabdominal pelvic ultrasound revealed a lower uterine segment/cervical fibroid measuring 7.5 × 5 × 7.8 cm (length × depth × width). Patient was diagnosed with abnormal uterine bleeding–leiomyoma and received five units of packed red blood cells, one unit of fresh frozen plasma, Venofer infusions, tranexamic acid, and medroxyprogesterone. She was discharged from the hospital after 4 days.

Conclusion
To date, only a handful of cases have been reported of female patient survival following severely low hemoglobin caused by abnormal uterine bleeding. This case adds to this literature, highlighting the remarkable degree of compensation that can lead to an alert, ambulatory, and oriented patient with abnormal uterine bleeding caused by leiomyoma.
Study of a class of fractional-order evolution hybrid differential equations using a modified Mittag-Leffler-type derivative
Authors: Shah Kamal , Abdeljawad Thabet , Abdalla Bahaaeldin , Hleili Manel 
Published: June 2024

AbstractThis work is devoted to using topological degree theory to establish a mathematical analysis for a class of fractional-order evolution hybrid differential equations using a modified Mittag–Leffler-type derivative. In addition, two kinds of Ulam–Hyers (U–H) stability results are deduced for the mentioned problem. A pertinent example is given to verify the results.
Identification of iron gall inks, logwood inks, and their mixtures using Raman spectroscopy, supplemented by reflection and transmission infrared spectroscopy
Authors: Retko Klara , Legan Lea , Kosel Janez , Ropret Polonca 
Published: June 2024

Abstract
Raman spectral references for various formulations of iron gall inks, logwood inks and mixtures of both types were acquired during this study. The samples, either liquid or dry inks and applied on paper, were analysed using a portable Raman spectrometer, both with 852 and 785 nm excitation lines, and a confocal dispersive Raman microscope with two different excitations, namely 785 and 532 nm. It was found that longer wavelengths are more suitable for the analysis of iron gall inks and that the spectral response of logwood inks is relatively more dependent on the excitation line. For the mixtures, it is suggested analyses be performed with both longer and shorter wavelengths, since with a 785 nm line mainly the characteristic features of the metal-polyphenol complex in iron gall inks are detected, while the spectra collected with a 532 nm excitation contain information on the presence of logwood inks. The study was complemented by non-invasive reflectance infrared spectroscopy, which enabled the detection of tannic acid in iron gall inks and in the mixtures, and by micro-Fourier transform infrared (FTIR) spectroscopy to complement the reference set. The study aims to contribute to the development of non-invasive protocols for identification of inks in historic and artistic works on paper, such as manuscripts and drawings.

Graphical Abstract
Thyrogrit, supplemented with a sub-optimal dose of levothyroxine, restores thyroid function in rat model of propylthiouracil-induced hypothyroidism
Authors: Balkrishna Acharya , Paliwal Ritu , Maity Madhulina , Varshney Yash , Sinha Sandeep , Varshney Anurag 
Published: June 2024

Abstract
Background
Hypothyroidism is a common endocrine ailment, whose current standard of care is hormonal replacement therapy with levothyroxine (LT4). There is a medical need for alternative and safer therapies as LT4 is associated with special treatment considerations and adverse effects. Thyrogrit (THY) is a polyherbal formulation indicated for the treatment of hypothyroidism. The present study, describes the characterization of the phytocompounds present in THY and its in-vivo efficacy in rat model of hypothyroidism, in combination with a sub-optimal dose of LT4.

Methods
Ultra High Performance Liquid chromatography was employed for the identification of the phytocompounds present in THY. For the evaluation of its in-vivo efficacy, female Wistar rats were administered THY orally, 15-days prior to disease induction, and continued throughout the experiment. Subsequently, hypothyroidism was induced by oral administration of propylthiouracil (PTU). From day 45 onwards, animals were administered orally with a sub-optimal dose of LT4 (2 μg/kg) till the end of the study. On day 79, animals were euthanized, blood was collected for measurement of thyroid hormones and other clinical chemistry parameters. Weights of liver, kidney and thyroid were recorded. Finally, the thyroid was subjected to histopathological evaluation through hematoxylin and eosin (H&E staining), immunohistochemistry as well as immunofluorescence.

Results
The principal phyto-components detected in THY by Ultra High Performance Liquid Chromatography included gallic acid, protocatechuic acid, corilagin, ellagic acid, piperine, guggulsterone E and Z, which are documented to exerted beneficial effects on thyroid function. In the in-vivo study, THY when supplemented with a low dose of levothyroxine restored the PTU-induced reduction in the serum levels of T3 and T4 and improved PTU-induced renal impairment. THY treatment ameliorated the hallmark histopathological changes associated with hypothyroidism and C-cell hyperplasia. Further, co-administration of THY and LT4 did not show any major non-clinical safety concerns even after the administration for more than twelve weeks.

Conclusion
This study has demonstrated that co-administration of THY and LT4 improves the PTU-evoked alterations in the thyroid ultrastructure and function, abrogates hypothyroidism-associated renal impairment and exhibits an acceptable basic safety profile.

Graphical abstract
Is conventional magnetic resonance imaging superior to radiography in the functional integrity evaluation of anterior cruciate ligament in patients with knee osteoarthritis?
Authors: Yu Zhenguo , Wang Hongqing , Wang Xiaoyu , Dong Xin , Dong Jie , Liang Qingchen , Sun Fenglong 
Published: June 2024

Abstract
Background
The functional integrity of the anterior cruciate ligament (ACL) influences surgical decision-making in patients with knee osteoarthritis (KOA). This study aimed to compare the diagnostic value of radiography and magnetic resonance imaging (MRI) in determining the functional status of ACL.

Methods
We analyzed 306 knees retrospectively using preoperative hip-to-ankle anteroposterior standing (APS) radiographs, anteroposterior (AP) and lateral knee radiographs, AP valgus stress (VS) force radiographs, and standard orthogonal MRI. Based on the intraoperative visualization, the knees were grouped into ACL functionally-intact and ACL functionally-deficient (ACLD) groups. The diagnostic validity and reliability were calculated based on the radiograph parameters such as hip-knee-ankle angle (HKA), medial proximal tibial angle (MPTA), lateral distal femoral angle (LDFA), posterior tibial slope (PTS), sagittal tibiofemoral subluxation (STFS), coronal tibiofemoral subluxation (CTFS), joint line convergence angle (JLCA), the maximum wear point of the proximal tibia plateau (MWPPT%), and MRI parameters including ACL grades and MWPPT%.

Results
HKA, MPTA, PTS, STFS, JLCA, and CTFS on APS and AP radiographs, and MWPPT% on radiographs and MRI showed a significant diagnostic value (P < 0.05). There were no statistically significant differences in the single parameters from radiographs and MRI. After constructing the logistic regression models, MRI showed higher sensitivity, specificity, and accuracy, reaching 96.8%, 79.9%, and 83.3%, respectively (P < 0.001).

Conclusions
In patients with KOA, the diagnostic value of single radiographic or MRI parameter in assessing the functional integrity of the ACL are equivalent. However, by constructing predictive models, MRI could significantly improve diagnostic validity compared with radiography.
Racial Disparities and Strategies for Improving Equity in Diagnostic Follow-Up for Abnormal Screening Mammograms
Authors: Manik Ritika , Grady Connor B. , Ginzberg Sara P. , Edmonds Christine E. , Conant Emily F. , Hubbard Rebecca A. , Fayanju Oluwadamilola M. 
Published: June 2024

PURPOSE
Black and White women undergo screening mammography at similar rates, but racial disparities in breast cancer outcomes persist. To assess potential contributors, we investigated delays in follow-up after abnormal imaging by race/ethnicity.

METHODS
Women who underwent screening mammography at our urban academic center from January 2015 to February 2018 and received a Breast Imaging Reporting and Data System 0 assessment were included. Kaplan-Meier estimates described distributions of time between diagnostic events from (1) screening to diagnostic imaging and (2) diagnostic imaging to biopsy. Multivariable logistic regression models estimated the associations between race/ethnicity and receipt of follow-up within 15 and 30 days.

RESULTS

Two thousand five hundred and fifty-four women were included (48.6% non-Hispanic [NH] Black, 38.2% NH White, 13.1% other/unknown). Median time between screening and diagnostic imaging varied by race/ethnicity (White: 7 days [IQR, 2-14]; Black: 12 days [IQR, 7-23]; other/unknown: 9 days [IQR, 5-21]). There were similar disparities in days between diagnostic imaging and biopsy (White: 12 [IQR, 7-24]; Black: 21 [IQR, 13-37]; other/unknown: 16 [IQR, 9-30]) and between screening and biopsy (White: 20 [IQR, 11-41]; Black: 35 [IQR, 22-63]; other/unknown: 27.5 [IQR, 17-42]). After adjustment, odds of diagnostic imaging follow-up within 15 days of screening were lower for Black versus White women (odds ratio, 0.59 [95% CI, 0.44 to 0.80];
P
< .001).

CONCLUSION
In this diverse cohort, disparities in timely diagnostic follow-up after abnormal breast screening were observed, with Black women waiting 1.75 times as long as White women to obtain a tissue diagnosis. National guidelines for time to diagnostic follow-up may facilitate more timely breast cancer care and potentially affect outcomes.
Thin elastic films and membranes under rectangular confinement
Authors: Sprenger A. R. , Reinken H. , Richter T. , Menzel A. M. 
Published: June 2024

Abstract
We address the deformations within a thin elastic film or membrane in a two-dimensional rectangular confinement. To this end, analytical considerations of the Navier-Cauchy equations describing linear elasticity are performed in the presence of a localized force center, that is, a corresponding Green's function is determined, under no-slip conditions at the clamped boundaries. Specifically, we find resulting displacement fields for different positions of the force center. It turns out that clamping regularizes the solution when compared to an infinitely extended system. Increasing compressibility renders the displacement field more homogeneous under the given confinement. Moreover, varying aspect ratios of the rectangular confining frame qualitatively affect the symmetry and appearance of the displacement field. Our results are confirmed by comparison with corresponding finite-element simulations.
Vaccine a promising immunotherapy option for head and neck cancer patients
Authors: Mohsin Syed Fareed 
Published: June 2024

Head and neck cancer (HNC) is a diversified group of tumors arising from the upper aerodigestive tract, encompassing the oral cavity, larynx, and pharynx. Globally, this particular cancer ranks sixth in prevalence, resulting in an annual mortality rate above 325,000 individuals. Surgery, radiation, and chemotherapy are the primary therapeutic options for HNC, which are frequently used in combination. Despite their extensive use, these treatments are typically unsuccessful and can significantly impair patient quality of life. Therapeutic vaccinations are administered to cancer patients instead of preventative immunizations administered to a healthy population. The efficacy of this modality has considerably transformed the application and success of cancer management by providing an additional and effective therapeutic option for patients. Cancer treatment has been revolutionized by introducing Immune Checkpoint receptors inhibitors (ICR), such as anti-CTLA4, anti-PD-1, and anti-PD-L1.3. ICR have also established immunity against self-generated cancerous cells. Cancer vaccines have shown extraordinary synergistic potential with checkpoint inhibitors to maximize tumor-specific CD8+ expansion and activity, which detects and destroys tumor cells. Personalized neoantigen vaccination therapies can potentially combat the heterogeneity of each patient’s tumor. The findings of this review suggest that recent advances in cancer immunology and genetics imply that cancer vaccination can be a promising alternative treatment for head and neck cancer patients. This review conducted a comprehensive literature search to identify relevant studies on immunotherapy options for head and neck cancer patients. The search strategy was designed to capture a wide range of peer-reviewed articles, conference proceedings, and grey literature from 2013 to 2023. The databases searched to ensure comprehensive coverage of the literature included PubMed, Web of Science, and Google Scholar; to include grey literature and articles not indexed in traditional databases.
doi: https://doi.org10.12669/pjms.40.7.8791
How to cite this: Mohsin SF. Vaccine a promising immunotherapy option for head and neck cancer patients. Pak J Med Sci. 2024;40(7):---------. doi: https://doi.org/10.12669/pjms.40.7.8791
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Finger Injury Related to Climbing: Anatomy, Function, Mechanism of Injury, Diagnosis, Treatment
Authors: Popławska Natalia Aleksandra , Śliz Justyna , Skorupska Marta , Woźniak Krzysztof , Czeczotka Magdalena Joanna , Martka Martyna Magdalena 
Published: June 2024

Introduction
Rock climbing has surged in popularity over the past few decades, attracting a diverse range of participants from recreational enthusiasts to professional athletes. While climbing offers numerous physical and mental benefits, it also presents significant injury risks. Rock climbing is a sport that imposes extreme stress on the fingers, particularly on the flexor pulley system. Injuries to these structures can severely impact a climber's ability to perform and progress in the sport. Understanding the anatomy, injury mechanisms, and treatment modalities is essential for effective management and prevention.
Aim of the study
The purpose of this narrative review is to comprehensively describe information on the anatomy, function, mechanism of injury, diagnosis, and treatment modalities of the finger flexor pulley system (FFPS).
Materials and methods
The methodology for the literature search involved using the keyword "pulley" and adding terms such as "treatment", "mechanism", "function", "anatomy", "diagnosis", and "symptoms". The search terms were entered into the PubMed and Google Scholar databases. The review works and clinical trials were taken into account.
Conclusion
Finger flexor pulley system (FFPS) strain is a common overuse injury in climbers, often caused by the crimp grip used in rock climbing. Pulleys A2 and A4 are particularly vulnerable. Diagnosis involves physical examination and imaging tests, such as ultrasonography and, if necessary, magnetic resonance imaging. Grade I to III injuries are typically treated conservatively, while surgical treatment may be necessary for grade IVb injuries. Using a splint or H-taping the fingers after an injury can help prevent further damage and provide support for the affected pulleys.
Biologic Therapies: Targeting Severe Asthma at the Molecular Level
Authors: Szewczyk Kamila , Szewczyk Bartłomiej , Krzesłowska Wiktoria Julia , Pytel Paulina , Wiśniewski Szymon , Hołownia Weronika 
Published: June 2024

Introduction:
Severe asthma is a chronic respiratory condition that affects a significant number of individuals, causing persistent inflammation of the airways and leading to recurrent symptoms such as wheezing, coughing, and shortness of breath. While conventional asthma treatments, including inhaled corticosteroids and bronchodilators, are generally effective for most asthma patients, they may not always provide sufficient relief for individuals with severe asthma. In such cases, the use of biologic agents licensed specifically for severe asthma can be a valuable treatment option.

Aim of the study:
This article aims to explore the different biologic agents licensed for severe asthma and delve into their effectiveness in managing this complex and challenging condition.

Material and methods:
Literature available in the PubMed database was reviewed using the following keywords: biologic agents for asthma; omalizumab; mepolizumab; bernalizumab; tezepelumab; monoclonal antibodies.
Conclusions:
These medications are designed to target the underlying mechanisms of severe asthma, addressing the root causes of the condition rather than just managing the symptoms. As a result, they have shown promising results in improving symptoms and reducing exacerbations in individuals with severe asthma. By understanding the potential benefits of these medications, healthcare professionals can make informed decisions when it comes to treating patients with severe asthma.
Comparison of first-year nursing students' GAD-7 scores: a pilot study focusing on Generation Z
Authors: Flynn Deborah , Barker Stuart 
Published: June 2024

Background: In a post-pandemic landscape, Generation Z (Gen Z) nursing students are increasingly facing mental health challenges, notably anxiety. This study investigated these challenges among first-year nursing students. Aims: The primary objective was to assess self-reported anxiety levels in first-year undergraduate nursing students, focusing on Gen Z, before or at the onset of their initial clinical placement post-pandemic. Methods: Employing a cross-sectional design, this study used the Generalized Anxiety Disorder-7 (GAD-7) questionnaire to evaluate anxiety levels. It encompassed first-year nursing students from various fields at a university in North East England, considering generational differences, field of nursing, and demographic variables. Findings: Results indicated anxiety levels among generational groups, with Gen Z students exhibiting extreme variations. Notably, students in Mental Health Nursing reported less anxiety than their counterparts in other nursing fields. The study also sheds light on the ramifications of the COVID-19 pandemic on student mental health. Conclusions: The study underscores the necessity for bespoke support systems in educational and clinical environments, particularly for Gen Z students. It advocates for comprehensive strategies in universities and clinical settings to nurture nursing students' emotional health, thereby enhancing their resilience and long-term career prospects
Religious Moderation Perspectives and Pratices in Muslim Youths With International Exposure
Authors: Adnan Muhammad , Husna Nailul , Fauziah Ni’matul 
Published: June 2024

Travel across border give opportunity to people to immerse in a diverse groups and societies. It is hoped to enrich life experiences that lays the groundwork for the creation of more harmonious and tolerant societies. Religious moderation, especially in Indonesian context, require tolerance, anti-violence, the sense of nationality and local culture acceptance from its citizen to maintain the harmonious, moreover, the unity of Indonesia as a country. Unfortunately, some Muslim youths were found to have low tolerance toward different religion groups. This study aims to assess if Muslim youths with international exposure have good moderation perspectives and practices in religion, including tolerance. This study is a quantitative descriptive with the help of survey tool to collect data from Muslim youths with international experiences. The analysis was carried out using univariate analysis. The results depict that more than 90% of the 155 respondents have good perspectives and practices toward religious moderation. Only practice of tolerance has slightly lower percentage which is 89%. More international programs for Muslim youths are encouraged to help them increase the level of tolerance toward differences