bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adjunctive thrombus aspiration versus conventional percutaneous coronary intervention in ST‐elevation myocardial infarction
Authors: Kikkert Wouter J. , Claessen Bimmer E. , van Geloven Nan , Baan Jan , Vis Marije M. , Koch Karel T. , Piek Jan J. , Tijssen Jan G.P. , Henriques Jose P.S. 
Published: August 2012

ObjectivesThe objective of this analysis is to determine the effects on mortality of thrombus aspiration during primary percutaneous coronary intervention (PPCI) for ST‐elevation myocardial infarction (STEMI) compared with conventional PCI.BackgroundAdjunctive thrombus aspiration in STEMI improves markers of myocardial reperfusion but evidence for improved survival is limited to the TAPAS trial.MethodsWe used data of 3,750 consecutive STEMI patients treated with either conventional PCI or thrombus aspiration between August 1, 2001 and January 1, 2009. For each patient, a propensity score was calculated based on clinical and angiographic characteristics, predicting a patient's probability of having been treated with thrombus aspiration. This propensity score was used in several ways to account for differences between patients treated with and without thrombus aspiration. In our primary analysis, patients treated with thrombus aspiration were matched one‐to‐one with patients treated with conventional PCI on their propensity score (1,391 matched pairs). Kaplan Meier and Cox regression models were used to estimate the influence of treatment on one‐year mortality.ResultsIn total, 1,502 patients (40.1%) were treated with thrombus aspiration. In the propensity matched cohort, after one year 7.2% of patients treated with thrombus aspiration had died compared with 9.3% of patients in the control group. The hazard ratio for one‐year mortality in patients treated with thrombus aspiration was 0.76 (95% CI: 0.59–0.99; P = 0.043). The hazard ratio remained materially unaltered and statistically significant in secondary analyses, varying between 0.61 and 0.77.ConclusionThe routine use of thrombus aspiration was associated with reduced one‐year mortality in this large real‐world patient cohort. These data support the observed survival benefit in the TAPAS trial. © 2012 Wiley Periodicals, Inc.
Off‐label use of percutaneous pulmonary valved stents in the right ventricular outflow tract: Time to rewrite the label?
Authors: Boshoff Derize E. , Cools Bjorn L.M. , Heying Ruth , Troost Els , Kefer Joelle , Budts Werner , Gewillig Marc 
Published: August 2012

IntroductionPercutaneous pulmonary valve implantation is now considered feasible and safe. “Native” right ventricular outflow tract (RVOT), small diameter conduits (<16 mm) and relatively large RVOT with a dynamic outflow aneurysm are currently considered off‐label uses. Extending indications creates concerns of safety, ethics, reimbursement, and liability.Aim of studyTo report the safety and feasibility of off‐label application of percutaneous pulmonary valve implantation.DesignRetrospective analysis of prospectively collected data.Patients and MethodsOff‐label indications: conduit‐free RVOT or patients with an existing but undersized conduit.ResultsTwenty‐one Melody® valves and two Sapien® valves were successfully implanted in 23 patients (16.9 years; range 6.1–80.5 years). In 22 patients, prestenting was performed 4.8 months (range 0–69.2) before valve implantation (15 covered and 13 bare stents). Stent endothelial ingrowth was allowed for at least 2 months prior to implantation of the percutaneous valve if stent stability or sealing by the covering was presumed to be insufficient. Group 1 patients (n = 8) had a “conduit‐free” RVOT after transannular/infundibular patch and after prestenting underwent percutaneous pulmonary valve implantation (PPVI), with a final RVOT diameter of 21.5 mm (range 16–26 mm). Group 2 patients consisted of two elderly patients with pulmonary valve stenosis and severe RVOT calcifications. Group 3 (n = 13) had an existing conduit (nominal 15.9 ± 3.2 mm; range 10–20 mm). The conduit was augmented from 14.7 ± 3.5 to 20 ± 1.6 mm with PPVI. The RVOT preparation and valve implantations were uneventful.ConclusionsPPVI is safe and feasible in selected patients with an off‐label indication. Creating an adequate “landing zone” by prestenting makes the procedure safe and predictable. Updating the indications for PPVI should be considered. © 2013 Wiley Periodicals, Inc.
Cause of death after transcatheter aortic valve implantation
Authors: Van Mieghem Nicolas M. , van der Boon Robert M. , Nuis Rutger‐Jan , Schultz Carl , van Geuns Robert‐Jan , Serruys Patrick W. , Kappetein Arie‐Pieter , van Domburg Ron T. , de Jaegere Peter P. 
Published: August 2012

ObjectivesTo evaluate survival and cause of death in a consecutive patient cohort undergoing Transcatheter Aortic Valve implantation (TAVI).BackgroundTAVI is a valid treatment option in patients with severe Aortic Stenosis (AS) who are deemed at (very) high operative risk. Because of (non‐)cardiac comorbidities life expectancy in this patient, population is reduced when compared with the general population.MethodsConsecutive patients with symptomatic aortic stenosis undergoing TAVI between November 2005 and December 2011 were included. (1) Survival status was obtained from the Dutch Civil Registry, (2) cause of death was derived by reviewing hospital charts, and (3) contacting referring physicians and patients' general practitioners.ResultsTwo hundred and thirty‐seven consecutive patients were included with an overall all‐cause mortality of 31% at a median follow up of 13 months (IQR 2–24 months). Four patients (1.6%) died < 48 hr of the TAVI procedure, and another 16 patients died up to the 30‐day interval representing an all‐cause 8.4% 30‐day mortality. Between 30 days and 1‐year another 30 patients died. Twenty‐four patients died >1 year post TAVI. The predominant cause of death >48 hr post TAVI was noncardiac. One third of these deaths were due to sepsis/infection, one‐fifth to cancer and stroke in 16%.ConclusionsIn our series of AS patients undergoing TAVI, the cause of death >48 hr post procedure was predominantly noncardiac at every time interval. Mortality was driven by sepsis/infection, cancer, and stroke. Rigorous patient selection may improve outcome after TAVI. © 2013 Wiley Periodicals, Inc.
Synthesis, Structure, and Reactivity of Borole‐Functionalized Ferrocenes
Authors: Braunschweig Holger , Chiu Ching‐Wen , Gamon Daniela , Kaupp Martin , Krummenacher Ivo , Kupfer Thomas , Müller Robert , Radacki Krzysztof 
Published: August 2012

AbstractHerein, we report on the synthesis of ferrocenylborole [Fc(BC4Ph4)2] featuring two borole moieties in the 1,1′‐positions. The results of NMR and UV/Vis spectroscopy and X‐ray diffraction studies provided conclusive evidence for the enhanced Lewis acidity of the boron centers resulting from the conjugation of two borole fragments. This finding was further validated by the reaction of [Fc(BC4Ph4)2] and the 4‐Me‐NC5H4 adduct of monoborole [Fc(BC4Ph4)], which led to quantitative transfer of the Lewis base. The coordination chemistry of ferrocenylboroles was further studied by examining their reactivity towards several pyridine bases. Accordingly, the strong Lewis acidity of boroles in general was nicely demonstrated by the reaction of [Fc(BC4Ph4)] with 4,4′‐bipyridine. Unlike common borane derivatives such as [FcBMe2], which only forms a 2:1 adduct, we also succeeded in the isolation of a 1:1 Lewis acid/base adduct, with one nitrogen donor of 4,4′‐bipyridine remaining uncoordinated. In addition, the reduction chemistry of ferrocenylboroles [Fc(BC4Ph4)] and [Fc(BC4Ph4)2] has been studied in more detail. Thus, depending on the reducing agent and the reaction stoichiometry, chemical reduction of [Fc(BC4Ph4)] might lead to the migration of the borolediide fragment towards the iron center, affording dianions with either η5‐coordinated C5H4 or η5‐coordinated BC4Ph4 moieties. In contrast, no evidence for borole migration was observed during reduction of bisborole [Fc(BC4Ph4)2], which readily resulted in the formation of the corresponding tetraanion. Finally, our efforts to further enhance the borole ratio in ferrocenylboroles aiming at the synthesis of [Fc(BC4Ph4)4] failed and, instead, generated an uncommon ansa‐ferrocene containing two borole fragments in the 1,1′‐positions and a B2C4 ansa‐bridge.
Viewing and Inducing Symmetry Breaking at the Single‐Molecule Limit
Authors: Tierney Heather L. , Jewell April D. , Baber Ashleigh E. , Iski Erin V. , Sykes E. Charles H. 
Published: August 2012

ABSTRACTSymmetry breaking by photons, electrons, and molecular interactions lies at the heart of many important problems as varied as the origin of homochiral life to enantioselective drug production. Herein we report a system in which symmetry breaking can be induced and measured in situ at the single‐molecule level using scanning tunneling microscopy. We demonstrate that electrical excitation of a prochiral molecule on an achiral surface produces large enantiomeric excesses in the chiral adsorbed state of up to 39%. The degree of symmetry breaking was monitored as a function of scanning probe tip state, and the results revealed that enantiomeric excesses are correlated with the intrinsic chirality in scanning probe tips themselves, as evidenced by height differences between single molecule enantiomers. While this work has consequences for the study of two‐dimensional chirality, more importantly, it offers a new method for interrogating the coupling of photons, electrons, and combinations of physical fields to achiral starting systems in a reproducible manner. This will allow the mechanism of chirality transfer to be studied in a system in which enantiomeric excesses are quantified accurately by counting individual molecules. Chirality 24:1051–1054, 2012. © 2012 Wiley Periodicals, Inc.
Platform for the Design of Process Control Structures of Dividing Wall Columns
Authors: Buck Christina , Fieg Georg 
Published: August 2012

AbstractDer Beitrag befasst sich mit dem systematischen Entwurf und Test von Prozessführungskonzepten für Trennwandkolonnen. Es wird eine Entwicklungsplattform präsentiert, die diese Gesamtaufgabe systematisch und weitgehend automatisch löst. Neben der Beschreibung der Bestandteile der Plattform und ihrer Funktionalitäten wird zudem ein praktisches Beispiel gezeigt, das die Anwendbarkeit der Plattform für die Entwicklung eines Prozessführungskonzepts einer Trennwandkolonne im Technikumsmaßstab belegt. Eine erfolgreiche, praktische Validierung des Konzepts rundet die Entwicklungsarbeiten ab.
Bacterial cytokinesis: From Z ring to divisome
Authors: Lutkenhaus Joe , Pichoff Sebastien , Du Shishen 
Published: August 2012

AbstractAncestral homologues of the major eukaryotic cytoskeletal families, tubulin and actin, play critical roles in cytokinesis of bacterial cells. FtsZ is the ancestral homologue of tubulin and assembles into the Z ring that determines the division plane. FtsA, a member of the actin family, is involved in coordinating cell wall synthesis during cytokinesis. FtsA assists in the formation of the Z ring and also has a critical role in recruiting downstream division proteins to the Z ring to generate the divisome that divides the cell. Spatial regulation of cytokinesis occurs at the stage of Z ring assembly and regulation of cell size occurs at this stage or during Z ring maturation. © 2012 Wiley Periodicals, Inc
Mid1/anillin and the spatial regulation of cytokinesis in fission yeast
Authors: Rincon Sergio A. , Paoletti Anne 
Published: August 2012

AbstractCell division is a critical and irreversible step in the cell cycle. The strategies that cells follow to regulate the position of the division plane must take into account the global geometry of the cell as well as position of the genetic material to ensure its accurate segregation into daughter cells of a given cell shape and size. Along the years, research on Schizosaccharomyces pombe, a well‐recognized model organism for cell division studies has allowed a detailed molecular understanding of the spatial mechanisms regulating cytokinesis. Division plane position in this unicellular rod‐shaped organism, which divides by the assembly and constriction of a medially placed actomyosin ring, largely depends on the anillin‐like protein Mid1. Therefore, the major pathways controlling the position of the division plane converge on Mid1. In this review, we make an overview of the studies that have deciphered how Mid1 localization and scaffolding activities are controlled over the cell cycle to ensure the symmetrical division of fission yeast cells. These studies have revealed new mechanisms generating spatial information based on nuclear shuttling of the division plane factor Mid1 and on the establishment of cortical inhibitory gradients of the cell polarity kinase Pom1. © 2012 Wiley Periodicals, Inc
Dipeptidyl Peptidase IV‐Activated Prodrugs of Anti‐Varicella Zoster Virus Bicyclic Nucleoside Analogues Containing Different Self‐Cleavage Spacer Systems
Authors: Diez‐Torrubia Alberto , Cabrera Silvia , De Meester Ingrid , Camarasa María‐José , Balzarini Jan , Velázquez Sonsoles 
Published: August 2012

AbstractA new type of double prodrug of the antiviral family of bicyclic nucleoside analogues (BCNA) bearing cyclization self‐cleavage spacers between the Val‐Pro dipeptide sequence as well as the parent compound were synthesized and evaluated with regard to activation by the DPPIV/CD26 enzyme and for their stability in human and bovine serum. In buffer solution, carbamate and ester prodrugs were found to be chemically stable. Most prodrugs containing a dipeptidyl linker efficiently converted into the BCNA parent drug. In contrast, the Val‐Pro alkyldiamino prodrugs converted predominantly into their alkyldiamino prodrug intermediates in the presence of CD26 and human serum. A marked increase in water solubility was observed for all prodrugs. In contrast to the parent compound, a tetrapeptide prodrug containing the Val‐Val dipeptide as a self‐cleavage spacer released substantial amounts of the BCNA parent drug at the basolateral side of Caco‐2 cell cultures and exhibited 15‐ to 20‐fold increased bioavailability in mice relative to the poorly bioavailable parent compound.
Microlocal Analysis of the Geometric Separation Problem
Authors: Donoho David , Kutyniok Gitta 
Published: August 2012

AbstractImage data are often composed of two or more geometrically distinct constituents; in galaxy catalogs, for instance, one sees a mixture of pointlike structures (galaxy superclusters) and curvelike structures (filaments). It would be ideal to process a single image and extract two geometrically “pure” images, each one containing features from only one of the two geometric constituents. This seems to be a seriously underdetermined problem but recent empirical work achieved highly persuasive separations.We present a theoretical analysis showing that accurate geometric separation of point and curve singularities can be achieved by minimizing the ℓ1norm of the representing coefficients in two geometrically complementary frames: wavelets and curvelets. Driving our analysis is a specific property of the ideal (but unachievable) representation where each content type is expanded in the frame best adapted to it. This ideal representation has the property that important coefficients areclustered geometricallyin phase space, and that at fine scales, there is very little coherence between a cluster of elements in one frame expansion and individual elements in the complementary frame. We formally introduce notions ofcluster coherenceandclustered sparsityand use this machinery to show that the underdetermined systems of linear equations can be stably solved by ℓ1minimization; microlocal phase space helps organize the calculations that cluster coherence requires. © 2012 Wiley Periodicals, Inc.
Fragmentation reduces regional‐scale spatial genetic structure in a wind‐pollinated tree because genetic barriers are removed
Authors: Wang Rong , Compton Stephen G. , Shi Yi‐Su , Chen Xiao‐Yong 
Published: August 2012

AbstractGene flow strongly influences the regional genetic structuring of plant populations. Seed and pollen dispersal patterns can respond differently to the increased isolation resulting from habitat fragmentation, with unpredictable consequences for gene flow and population structuring. In a recently fragmented landscape we compared the pre‐ and post‐fragmentation genetic structure of populations of a tree species where pollen and seed dispersal respond differentially to forest fragmentation generated by flooding. Castanopsis sclerophylla is wind‐pollinated, with seeds that are dispersed by gravity and rodents. Using microsatellites, we found no significant difference in genetic diversity between pre‐ and post‐fragmentation cohorts. Significant genetic structure was observed in pre‐fragmentation cohorts, due to an unknown genetic barrier that had isolated one small population. Among post‐fragmentation cohorts this genetic barrier had disappeared and genetic structure was significantly weakened. The strengths of genetic structuring were at a similar level in both cohorts, suggesting that overall gene flow of C. sclerophylla has been unchanged by fragmentation at the regional scale. Fragmentation has blocked seed dispersal among habitats, but this appears to have been compensated for by enhanced pollen dispersal, as indicated by the disappearance of a genetic barrier, probably as a result of increased wind speeds and easier pollen movement over water. Extensive pollen flow can counteract some negative effects of fragmentation and assist the long‐term persistence of small remnant populations.
A New Design of Electrochemical and Optical Biosensors Based on Biocatalytic Growth of Au Nanoparticles – Example of Glucose Detection
Authors: Bourigua S. , Maaref A. , Bessueille F. , Renault N. Jaffrezic 
Published: August 2012

AbstractA simple strategy for the design of glucose biosensors based on enzyme‐induced growth of gold nanoparticles (AuNPs) is proposed. It is for the first time applied for EIS and SPR glucose detection. AFM topography measurements proved that small spherical nanoparticles could grow on the enzyme‐modified surface after addition of glucose. The biosensor exhibits sensitive response to the analyte with a detection limit of 8 µM for the EIS (Electrochemical Impedance Spectroscopy) transduction and 10 µM for the SPR (Surface Plasmon Resonance) transduction associated to a rather large dynamic range: 0.008–4 mM and 0.01–7 mM, respectively. Moreover, the interbiosensor showed good reproducibility (RSD=8.3 %, n=4).
An ALE finite element method for a coupled Stefan problem and Navier–Stokes equations with free capillary surface
Authors: Bänsch Eberhard , Paul Jordi , Schmidt Alfred 
Published: August 2012

SUMMARYIn this article, an ALE finite element method to simulate the partial melting of a workpiece of metal is presented. The model includes the heat transport in both the solid and liquid part, fluid flow in the liquid phase by the Navier–Stokes equations, tracking of the melt interface solid/liquid by the Stefan condition, treatment of the capillary boundary accounting for surface tension effects and a radiative boundary condition.We show that an accurate treatment of the moving boundaries is crucial to resolve their respective influences on the flow field and thus on the overall energy transport correctly. This is achieved by a mesh‐moving method, which explicitly tracks the phase boundary and makes it possible to use a sharp interface model without singularities in the boundary conditions at the triple junction.A numerical example describing the welding of a thin‐steel wire end by a laser, where all aforementioned effects have to be taken into account, proves the effectiveness of the approach.Copyright © 2012 John Wiley & Sons, Ltd.
Dynamic contrast‐enhanced MR perfusion imaging of head and neck tumors at 3 Tesla
Authors: Furukawa Matakazu , Parvathaneni Upendra , Maravilla Kenneth , Richards Todd L. , Anzai Yoshimi 
Published: August 2012

AbstractBackgroundDynamic contrast‐enhanced (DCE) MR perfusion imaging allows assessment of vascular density and integrity of tumors. The purpose of this study was to determine the diagnostic efficacy of time intensity curve analysis on DCE MRI for characterization of head and neck tumors.MethodsTwenty patients underwent T1‐weighted fast field echo DCE MRI with temporal resolution of 2.6 seconds. In total, 100 dynamic phases covering 20 slices were obtained in 4.5 minutes. Time to peak (TTP), relative maximum enhancement (RME) ratio, and relative washout ratio (RWO) were calculated.ResultsMalignant tumors had a significantly lower RME (p = .025) and prolonged TTP with lower RWO than benign lesions. Postradiation changes had a significantly longer TTP (p = .024) and lower RWO (p = .007) than did postradiation recurrent tumors. Receiver operating characteristic (ROC) analysis revealed RWO had highest accuracy (area under the curve [AUC] = 1.0).ConclusionsDCE MR perfusion imaging provides pivotal information regarding microcirculation, potentially improves differentiation of malignant tumor from postradiation changes. © 2012 Wiley Periodicals, Inc. Head Neck, 2013
Expression of the receptor tyrosine kinase recepteur d'origine nantais and its association with tumor progression in hypopharyngeal cancer
Authors: Yoon Tae Mi , Kim Sun‐Ae , Park Young‐Lan , Lee Kyung‐Hwa , Sung Myung‐Whun , Lee Joon Kyoo , Lim Sang Chul , Chung Ik‐Joo , Joo Young‐Eun 
Published: August 2012

AbstractBackgroundThe purpose of this study was to investigate expression of recepteur d'origine nantais (RON) in human hypopharyngeal squamous cell carcinoma (SCC) and to determine whether RON affects tumor cell behavior in hypopharyngeal SCC cell line and if this would serve as a target for molecular therapy in a preclinical model.MethodsReverse transcriptase‐polymerase chain reaction, immunohistochemistry, Western blotting, cell invasion, migration, proliferation, and apoptosis assays were used to assess alteration of RON expression and its impact to cancer progression in human hypopharyngeal SCC.ResultsImmunoreactivity of RON was observed in hypopharyngeal SCC tissues relative to adjacent normal mucosa in all cases. RON protein expression was significantly increased in metastatic lymph nodes than nonmetastatic lymph nodes by Western blotting. Knockdown of RON resulted in significantly reduced cell invasion, migration, and proliferation in human hypopharyngeal SCC cells. Knockdown of RON enhanced cell apoptosis through activation of caspase 3, caspase 7, and poly ADP‐ribose polymerase (PARP).ConclusionThese results indicate that knockdown of RON expression may be associated with the reversal of invasive phenotype in hypopharyngeal SCC. © 2012 Wiley Periodicals, Inc. Head Neck, 2013
Raman spectroscopy provides a powerful, rapid diagnostic tool for the detection of tuberculous meningitis in ex vivo cerebrospinal fluid samples
Authors: Sathyavathi R. , Dingari Narahara Chari , Barman Ishan , Prasad P. S. R. , Prabhakar Subhashini , Narayana Rao D. , Dasari Ramachandra R. , Undamatla Jayanthi 
Published: August 2012

AbstractIn this letter, we propose a novel method for diagnosis of tuberculous meningitis using Raman spectroscopy. The silicate Raman signature obtained from Mycobacterium tuberculosis positive cases enables specific and sensitive detection of tuberculous meningitis from acquired cerebrospinal fluid samples. The association of silicates with the tuberculosis mycobacterium is discussed. We envision that this new method will facilitate rapid diagnosis of tuberculous meningitis without application of exogenous reagents or dyes and can be aptly used as a complementary screening tool to the existing gold standard methods. (© 2013 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)