bluuebunny/crossref_metadata_2025_split huggingface dataset:
Progression of white matter hyperintensities is related to blood pressure increases and global cognitive decline – A registered report
Authors: Beyer Frauke , Lammer Laurenz , Loeffler Markus , Riedel-Heller Steffi , Debette Stéphanie , Villringer Arno , Witte A. Veronica 
Published: June 2024

Abstract
White matter hyperintensities (WMH) reflect cerebral small vessel disease (cSVD), a major brain pathology contributing to cognitive decline and dementia. Vascular risk factors, including higher diastolic blood pressure (DBP), have been associated with the progression of WMH yet longitudinal studies have not comprehensively assessed these effects for abdominal obesity or reported sex/gender-specific effects. In this pre-registered analysis of a longitudinal population-based neuroimaging cohort, we investigated the association of baseline DBP and waist-to-hip ratio with WMH progression in linear mixed models. We also examined the relationship of WMH progression and executive and global cognitive function. We conducted gender interaction and stratified analyses. We included data from 596 individuals (44.1 % females, mean age = 63.2 years) with two MRI scans over approximately 6 years. We did not find a significant association of baseline DBP with WMH progression. WMH progression significantly predicted global cognitive decline but not decline in executive function. In exploratory analyses, increases in DBP as well as baseline and increase in systolic blood pressure were associated with WMH progression, confined to frontal periventricular regions. There was no association of WHR nor any gender-specific associations with WMH progression. Adequate BP control might contribute to limit WMH progression and negative effects on global cognitive function in the middle-aged to older population for men and women.
The relationship between SV2A levels, neural activity, and cognitive function in healthy humans: A [11C]UCB-J PET and fMRI study
Authors: Shatalina Ekaterina , Onwordi Ellis Chika , Whitehurst Thomas , Whittington Alexander , Mansur Ayla , Arumuham Atheeshaan , Statton Ben , Berry Alaine , Marques Tiago Reis , Gunn Roger N. , Natesan Sridhar , Nour Matthew M. , Rabiner Eugenii A. , Wall Matthew B. , Howes Oliver D. 
Published: June 2024

Abstract
Synaptic terminal density is thought to influence cognitive function and neural activity, yet its role in cognition has not been explored in healthy humans. We examined these relationships using [11C]UCB-J positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) in 25 healthy adults performing cognitive function tasks in the scanner. We found a significant positive association between synaptic terminal density, indicated by [11C]UCB-J PET distribution volume ratio (DVRcs), and neural activity during task switching (PLS-CA, second canonical component, r = 0.63, p = 0.043) with the thalamus-putamen data positively contributing to this relationship (PLS-CA loading 0.679, exploratory Pearson’s correlation r = 0.42, p = 0.044, uncorrected). Furthermore, synaptic terminal density predicted switch cost (PLS-R, R2 = 0.45, RMSE = 0.06, p = 0.022), with DVRcs negatively correlating with switch cost in key brain regions including the dorsolateral prefrontal cortex and posterior frontal cortex. Conversely, no significant relationships were observed between [11C]UCB-J DVRcs and neural activity or performance measures in the N-back working memory task, suggesting interindividual differences in synaptic terminal density may be more closely related to some cognitive functions and not others.
Using respiratory challenges to modulate CSF movement across different physiological pathways: An fMRI study
Authors: Nair Vidhya Vijayakrishnan , Diorio Tyler C. , Wen Qiuting , Rayz Vitaliy L. , Tong Yunjie 
Published: June 2024

Abstract
With growing evidence signifying the impact of cerebrospinal fluid (CSF) flow in facilitating waste clearance from the brain and potential pathophysiological links to neurodegenerative disorders, it is of vital importance to develop effective methods to modulate CSF flow in the brain. Here, we attempt this by means of simple commonly used respiratory challenges—paced breathing and breath holding. Functional Magnetic Resonance Imaging scans of the brain and neck respectively were used to record the craniad and caudad CSF movements at the fourth ventricle from eight healthy volunteers during paced breathing and breath holding. Further, we utilized a novel approach for the first time to combine these separately acquired unidirectional CSF movement signals to compare the CSF flow in both directions (in the fourth ventricle) with the respiratory stimuli as a physiological control. Our results demonstrate that these respiratory challenges enhance the magnitude as well as control the direction of CSF movement in the fourth ventricle. They also reveal the capability of blood CO2 concentration changes (induced by respiratory challenges) in the low-frequency range to bring about these CSF movement modulations. Finally, we also successfully report our novel approach where we use these breathing challenges as a unique control condition to detect the small net CSF flows from independently captured unidirectional signals.
Predicting brain age across the adult lifespan with spontaneous oscillations and functional coupling in resting brain networks captured with magnetoencephalography
Authors: Hardy Samuel , Roberts Gill , Ventresca Matthew , Dunkley Benjamin T. 
Published: June 2024

Abstract
The functional repertoire of the human brain changes dramatically throughout the developmental trajectories of early life and even all the way throughout the adult lifespan into older age. Capturing this arc is important to understand healthy brain ageing, and conversely, how injury and diseased states can lead to accelerated brain ageing. Regression modelling using lifespan imaging data can reliably predict an individual’s brain age based on expected arcs of ageing. One feature of brain function that is important in this respect, and understudied to date, is neural oscillations—the rhythmic fluctuations of brain activity that index neural cell assemblies and their functioning, as well as coordinating information flow around networks. Here, we analysed resting-state magnetoencephalography (MEG) recordings from 367 healthy participants aged 18 to 83, using two distinct statistical approaches to link neural oscillations and functional coupling with that of healthy ageing. Spectral power and leakage-corrected amplitude envelope correlations were calculated for each canonical frequency band from delta through gamma ranges. Spatially and spectrally consistent associations between healthy ageing and neurophysiological features were found across the applied methods, showing differential effects on neural oscillations, with decreasing amplitude of low frequencies throughout the adult lifespan, and increasing high-frequency amplitude. Functional connectivity within and between resting-state brain networks mediated by alpha coupling generally decreased throughout adulthood and increased in the beta band. Predictive modelling of brain age via regression showed an age-dependent prediction bias, resulting in overestimating the age of younger people (&lt;40 years old) and underestimating the age of older individuals. These findings evidence strong age-related neurophysiological changes in oscillatory activity and functional networks of the brain as measured by resting-state MEG and that cortical oscillations are moderately reliable markers for predictive modelling. For researchers in the field of predictive brain age modelling with neurophysiological data, we recommend attention is paid to predictive biases for younger and older age ranges and consider using specific models for different age brackets. Nevertheless, these results suggest brain age prediction from MEG data can be used to model arcs of ageing throughout the adult lifespan and predict accelerated ageing in pathological brain states.
Population genetics of the endemic Large-crested toad (Incilius cristatus): a declining and critically endangered species
Authors: Zolá-Rodríguez Meghan Ivette , Manuel García-Feria Luis , González-Romero Alberto 
Published: June 2024

Abstract
The Large-crested toad is an endemic species of the mountain cloud forests of the Sierra Madre Oriental in Mexico. It is listed as endangered, and the population trend is decreasing. We used mitochondrial fragments 12S (450 bp) and cytochrome b (410 bp) from four toads’ populations from remnant fragments of mountain cloud forest in Puebla and Veracruz to estimate the genetic’ structure, gene flow, and demographic history. The 12S gene had a single haplotype and null nucleotide diversity. The cytochrome b fragment showed 4 haplotypes, intermediate nucleotide diversity (), and strong genetic structuring (). Demographic history suggests that there is a low effective population size (), possibly due to post-bottleneck expansion and contraction events in some populations. Current difficulty finding individuals at localities where they had been previously documented suggests that the population continues to decline, resulting in low diversity and gene flow. Habitat fragmentation and loss, as well as water pollution at breeding sites, increases the probability of extinction of this species. The importance of establishing conservation strategies for the habitat and genetic diversity of the remaining populations is highlighted.
Response of Subpolar North Atlantic Meridional Overturning Circulation to Variability in Surface Winds on Different Timescales
Authors: Markina Margarita Y. , Johnson Helen L. , Marshall David P. 
Published: June 2024

Abstract
A large part of the variability in the Atlantic meridional overturning circulation (AMOC) and thus uncertainty in its estimates on interannual time scales comes from atmospheric synoptic eddies and mesoscale processes. In this study, a suite of experiments with a 1/12° regional configuration of the MITgcm is performed where low-pass filtering is applied to surface wind forcing to investigate the impact of subsynoptic (<2 days) and synoptic (2–10 days) atmospheric processes on the ocean circulation. Changes in the wind magnitude and hence the wind energy input in the region have a significant effect on the strength of the overturning; once this is accounted for, the magnitude of the overturning in all sensitivity experiments is very similar to that of the control run. Synoptic and subsynoptic variability in atmospheric winds reduce the surface heat loss in the Labrador Sea, resulting in anomalous advection of warm and salty waters into the Irminger Sea and lower upper-ocean densities in the eastern subpolar North Atlantic. Other effects of high-frequency variability in surface winds on the AMOC are associated with changes in Ekman convergence in the midlatitudes. Synoptic and subsynoptic winds also impact the strength of the boundary currents and density structure in the subpolar North Atlantic. In the Labrador Sea, the overturning strength is more sensitive to the changes in density structure, whereas in the eastern subpolar North Atlantic, the role of density is comparable to that of the strength of the East Greenland Current.

Significance Statement
A key issue in understanding how well the Atlantic meridional overturning circulation is simulated in climate models is determining the impact of synoptic (2–10 days) and subsynoptic (shorter) wind variability on ocean circulation. We find that the greatest impact of wind changes on the strength of the overturning is through changes in energy input from winds to the ocean. Variations in winds have a more modest impact via changes in heat loss over the Labrador Sea, alongside changes in wind-driven surface currents. This study highlights the importance of accurately representing the density in the Labrador Sea, and both the strength and density structure of the East Greenland Current, for the correct representation of overturning circulation in climate models.
The longitudinal correlates of breakup distress in early young adulthood: Future distress and future benefits
Authors: Shulman Shmuel , Yonatan-Leus Refael 
Published: June 2024

Objectives: Existing research on romantic breakups focused on the predictors of breakup, or on its emotional and behavioral sequelae. The current study examines the longitudinal correlates of a breakup experience over a period of eight years, and questions whether breakup experiences may also have negative and positive outcomes. Methods: Data were collected from 124 Israeli emerging adults (mean age 20.22 years; 79 females). Participants were approached again at ages 23, 25, and 28. Breakup distress was assessed at each wave. At age 28, participants’ well-being, as well as their romantic capacities, were evaluated. Results: The intensity of breakup distress at age 20 was not found to be associated with future well-being. However, increased accumulating distress explained a greater number of depressive and anxiety symptoms, and reports of feeling insecure about a partner’s availability and responsiveness, at age 28. In-depth interviews with participants about their romantic relationships at age 28 showed that breakup distress at age 20 was associated with greater romantic competence at age 28, explaining better capacity to learn from past romantic experiences and draw lessons for future behavior. In addition, earlier breakup distress was associated with more coherent accounts of romantic relationships at age 28. Conclusions: Findings suggest that young adults are likely to experience a number of breakup events during their twenties, and the accumulating breakup experiences can affect future well-being. The experience of a breakup might not necessarily associate with negative future outcomes, while an earlier breakup experience could also serve as a positive learning arena for future relationships. Social policy: Perception of romantic dissolution in a comprehensive manner could be helpful for understanding that breakups are probably part of the normative development of romantic relationships among young adults, and should not be perceived only from a deficit perspective.
Measurement properties of the Foot Function Index (FFI) questionnaire: A systematic review
Authors: Cervera-Garvi Pablo , Galan-Hurtado Maria Hermas , Ortega-Avila Ana Belen , Marchena-Rodriguez Ana , Lopezosa-Reca Eva , Castillo-Dominguez Alejandro , Diaz-Miguel Salvador 
Published: June 2024

Objective Large numbers of people are subject to alterations and pathologies in the foot. To quantify how these problems of foot function affect the quality of life, clinicians and researchers have developed measures such as the Foot Function Index (FFI). Our aim is to determine the methodological quality of the FFI including adaptations to other languages. Data sources The studies considered in this review were extracted from the PubMed, Embase and CINAHL databases. The inclusion criteria were followed: (1) studies of patients with no previous foot or ankle pathology and aged over 18 years; (2) based on English-language patient-reported outcome measures that assess foot function; (3) the patient-reported outcome measures should present measurement properties based on COnsensus-based Standards for the selection of health Measurement Instruments (COSMIN) criteria. Review methods The systematic review was conducted following the COSMIN criteria to establish the methodological quality of the original FFI, together with its variants and adaptations. The last search was carried out in May 2024. Results Of the 1994 studies obtained in the preliminary search, 20 were eligible for inclusion in the final analysis. These results are the validations and cross-cultural adaptations to the following languages: the original FFI has cross-cultural adaptation in 13 languages and the FFI-Revised Short Form has been adapted and validated for use in 2 languages. Conclusion In terms of methodological quality, the FFI-Revised Short Form questionnaire is a valuable instrument for evaluating ankle and foot function and could usefully be expanded to be available in more languages.
The additional role of anti-nucleosome antibodies in the prediction of renal damage in systemic lupus erythematosus based on CSTAR (XXV)
Authors: Ding Yufang , Zhou Yangzhong , Zhao Jiuliang , Wu Chanyuan , Zhang Shangzhu , Jiang Nan , Qian Junyan , Zhang Li , Li Jing , Xu Dong , Leng Xiaomei , Wang Qian , Tian Xinping , Li Mengtao , Zeng Xiaofeng 
Published: June 2024

Objectives The predominant determinant of an unfavorable prognosis among Systemic Lupus Erythematosus (SLE) patients resides in the irreversible organ damage. This prospective cohort study aimed to identify the additional value of anti-nucleosome antibodies on organ damage accumulation in SLE patients. Methods Based on the Chinese SLE Treatment and Research group (CSTAR) registry, demographic characteristics, autoantibodies profiles, and clinical manifestations were collected at baseline. Follow-up data were collected by reviewing clinical records. Results Of 2481 SLE patients with full follow-up data, 663 (26.7%) were anti-nucleosome antibodies positive and 1668 (68.0%) were anti-dsDNA antibodies positive. 764 (30.8%) patients developed new organ damage during a mean follow-up of 4.31 ± 2.60 years. At baseline, patients with positive anti-nucleosome antibodies have a higher rate of lupus nephritis (50.7% vs 36.2%, p < .001). According to the multivariable Cox regression analysis, both anti-nucleosome (HR = 1.30, 95% CI, 1.09-1.54, p < .001) and anti-dsDNA antibodies (HR=1.68, 95% CI, 1.38-2.05, p < .001) were associated with organ damage accumulation. Anti-nucleosome (HR = 2.51, 95% CI, 1.81-3.46, p < .001) and anti-dsDNA antibodies (HR = 1.69, 95% CI, 1.39-2.06, p < .001) were independent predictors for renal damage. Furthermore, the combination of the two antibodies can provide more accurate information about renal damage in overall SLE patients (HR = 3.19, 95% CI, 2.49-4.10, p < .001) and patients with lupus nephritis at baseline (HR = 2.86, 95% CI, 2.29-3.57, p < .001). Conclusion Besides anti-dsDNA antibodies, anti-nucleosome antibodies can also provide information about organ damage accrual during follow-up. The ability of co-positivity of anti-nucleosome and anti-dsDNA antibodies in predicting renal damage may lead to additional benefits in the follow-up of these patients.
Health care workers’ qualitative descriptions of ethically challenging situations evoking moral distress during Covid-19
Authors: Glad Kristin Alve , Wøien Hilde , Stensland Synne Øien , Reitan Solveig Klebo , Zwart John Anker Henrik , Atar Dan , Dyb Grete , Bondjers Kristina 
Published: June 2024

Background The high public demand for healthcare services during the COVID-19 pandemic and strict infection control measures, coupled with threat of severe illness and death, and limited resources, led to many healthcare workers (HCWs) experiencing ethically challenging situations (ECSs). Objective To systematically explore first-hand accounts of ECS-evoking moral distress among HCWs during this public health emergency. Research design This was an open cohort study. All participants were asked whether they had been in ECS-evoking moral distress during the pandemic. Those who had were asked to describe these situations. Answers were systematically analyzed according to three levels of root causes for ECSs, using thematic analysis. Participants and research context In January 2022, 977 HCWs from four Norwegian university hospitals participated. Ethical considerations The study received ethical approval from the Norwegian Ethical Review Authority (No. 130944). Results In total, 508 participants (52%) reported that they had experienced ECS-evoking moral distress during the pandemic, whereof 323 provided a qualitative description. We found that while a few reported ECSs caused at the patient level, and some described situations at the unit/team level, the vast majority reported situations caused at the system level, predominantly related to resource scarcity, particularly poor staffing. Conclusion Our findings strongly indicate that efforts to mitigate moral distress among HCWs should be targeted at the system level. More specifically, the study findings highlight resource limitations, particularly poor staffing, as a major cause of moral distress during the pandemic.
Compressive Strength of Midfoot Fusion Nail vs Midfoot Fusion Bolt and Role of Subtalar Fusion in Midfoot Charcot Fixation Model
Authors: Anciano Victor , Barcel Anthony , Kaiser Philip , Habet Nahir , Wang Shangcheng , Duemmler Marc , Edwards Campbell , Irwin Todd A. , Jones Carroll 
Published: June 2024

Background: Operative management of midfoot Charcot arthropathy often involves an extended midfoot arthrodesis with intramedullary bolts for fixation, a method called “beaming.” Recently intramedullary nails have been introduced for the same indication, presumably providing stronger fixation. This study compares midfoot fusion nails to bolts with regard to stiffness and compressive ability. Additionally, we assessed how the addition of a subtalar fusion affects the construct. Methods: Medial column fusions were performed on 10 matched cadaver foot specimens with either a midfoot fusion nail or bolt. Specimens underwent cyclical compression loading, and displacement was measured. Separately, compressive forces produced were compared between the 2 fixation constructs using a synthetic bone block model. Lastly, another 10 matched specimens with midfoot fusion nails were evaluated with or without subtalar fusions. Results: No differences in stiffness were found in comparing matched specimens between nail vs bolt or comparing nail only without subtalar fusion (STF) vs nail with STF. The compressive force produced by the nail specimens was significantly and substantially greater than the bolted specimens (751.7 vs 139.0 N, P = .01). The accumulated height drop at the midfoot after cycling was 0.5 mm more in the nail group than in the bolt group (1.72 vs 1.22 mm, P = .008). The nail with STF group had greater initial height drop at the midfoot than the nail-only group (0.68 vs 0.34 mm, P = .035) with similar initial height drop at the ankle. However, there were no differences in strength among the matched pairs of midfoot nail-only vs midfoot nail with STF as measured by displacement after fatigue or maximum force at load to failure. Conclusion: The overall cadaveric comparisons between matched pairs of nails vs bolts, and nail-only vs nail with STF, did not provide noteworthy differences between the groups with regard to strength or stiffness. However, the compressive force of the midfoot fusion nail was far superior to the bolt in a synthetic bone model. These data provide valuable insight comparing implants used in Charcot midfoot arthrodesis.