bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment with ephrin B2 positively impacts the abnormal metabolism of human osteoarthritic chondrocytes
Authors: Kwan Tat Steeve , Pelletier Jean-Pierre , Amiable Nathalie , Boileau Christelle , Lavigne Martin , Martel-Pelletier Johanne 
Published: August 2009

Abstract
Introduction
Members of the ephrin system, the ephrin receptor erythropoietin-producing hepatocellular B4 (EphB4) and its specific ligand, ephrin B2, appear to be involved in the bone remodelling process. We recently showed that their interaction inhibits the resorptive activity of human osteoarthritic (OA) subchondral bone osteoblasts. Hence, we further investigated the possible implication of these ephrin members on the catabolic/anabolic activities of human OA chondrocytes.

Methods
EphB4 receptor and ephrin B2 levels were determined by quantitative PCR and immunohistochemistry, and the effects of ephrin B2 on the expression/production of factors involved in the OA process.

Results
EphB4 receptors and ephrin B2 ligands are expressed and produced by human normal and OA chondrocytes. Ephrin B2 protein was found at similar levels in both cartilage types, whereas EphB4 receptor expression (P < 0.0001) and production (P < 0.01) levels were significantly increased in OA chondrocytes/cartilage. Ephrin B2 treatment significantly inhibited the interleukin (IL)-1beta, IL-6, matrix metalloproteinase-1 (MMP-1), MMP-9, MMP-13, and proteinase-activated receptor-2 (PAR-2) gene expression levels, whereas MMP-2 was unaffected, and significantly increased collagen type II, a cartilage specific macromolecule. It also inhibited the IL-1beta stimulated protein production of IL-6, MMP-1 and MMP-13.

Conclusions
Our study is the first to provide data on the presence and role of ephrin B2/EphB4 receptors in human chondrocytes/cartilage. Data showed that ephrin B2 treatment positively impacts the abnormal metabolism of OA cartilage by inhibiting important catabolic factors involved in this disease at the same time as increasing anabolic activity.
Cytochrome c551 Is a Mediator of Electron Transfer between Copper-Containing Nitrite Reductase and Azurin in a Denitrifying Bacterium, Achromobacter xylosoxidans
Authors: Koteishi Hiroyasu , Nojiri Masaki , Nakagami Takuya , Yamaguchi Kazuya , Suzuki Shinnichiro 
Published: August 2009

Abstract
Cu-containing nitrite reductase from a denitrifying bacterium, Achromobacter xylosoxidans GIFU1051 (the organism formerly known as Alcaligenes xylosoxidans), can accept an electron from three possible electron donors (cytochrome c551 and two azurins). We have kinetically demonstrated that cytochrome c551 functions as a mediator in the electron flow processes between the enzyme and two azurins.
Structural and Optical Properties of Burr-Like CuS/Cu9S5 Microwires and Cu9S5 Microspheres Synthesized by a Two-Step Solvothermal Method
Authors: Fan Libo , Feng Tuanhui , Wang Peng , Zhang Chunli , Feng Zhibo 
Published: August 2009

Abstract
Burr-like CuS/Cu9S5 microwires and Cu9S5 microspheres can be synthesized by a two-step solvothermal method. Experiment results indicated that the CuS/Cu9S5 microwires (diameter of ca. 300 nm and length of several micrometers) and Cu9S5 microspheres (diameter of ca. 800 nm) obtained by this method had uniform morphologies and large product. X-ray diffraction (XRD), high-resolution transmission electron microscopy (HR-TEM), and field-emission scanning electron microscopy (FE-SEM) experiments were carried out to characterize them. Fourier transform infrared (FT-IR) spectra and thermogravimetric analysis (TGA) experiments were carried out to study the components and thermal stabilization of the precursors. A possible formation mechanism and ultraviolet–visible (UV–vis) absorption spectra are also described in this paper.
Controlled Synthesis of TT Phase Niobium Pentoxide Nanowires Showing Enhanced Photocatalytic Properties
Authors: Saito Kenji , Kudo Akihiko 
Published: August 2009

Abstract
The controlled synthesis of niobia nanowires with TT (tief–tief) phase (TT-Nb2O5-NW) that is the stable phase at low temperature was accomplished through calcination of niobium-based amorphous nanowires (Nb2O5-NW) composed of closely packed primary particles, obtained by the reaction of water-soluble niobium oxo-oxalate complex (NH4)3[NbO(Ox)3]·H2O (Ox = oxalate) with trioctylamine (TOA) employed as a structure-directing agent. TT-Nb2O5-NW gave a sharp absorption edge, which agreed well with that of the same crystalline phase of bulk niobia (TT-Nb2O5-B), suggesting no influence on the band gap energies by the shape transformation. An aqueous suspension containing TT-Nb2O5-NW and a sacrificial reagent was irradiated with white light (λ &gt; 300 nm) from a Xe lamp to afford the enhanced photocatalytic activities for H2 or O2 evolution compared with that of conventional TT-Nb2O5-B.
Microwave-Assisted Synthesis of Monodisperse Nickel Nanoparticles Using a Complex of Nickel Formate with Long-Chain Amine Ligands
Authors: Yamauchi Tomohisa , Tsukahara Yasunori , Sakamoto Tetsuo , Kono Takumi , Yasuda Makoto , Baba Akio , Wada Yuji 
Published: August 2009

Abstract
We have successfully prepared face-centered cubic (fcc) Ni nanoparticles by the intramolecular reduction of Ni2+ ion contained in a formate complex having long-chain amine ligands within an extremely short time under microwave irradiation. Formate ion coordinated to Ni2+ ion acted as a reducing agent for Ni2+ in this reaction and finally decomposed to hydrogen and carbon dioxide. Ligation of the long-chain amine lowered the reaction temperatures by decreasing the energy barrier required for the reduction of the nickel formate complex. Monodisperse Ni nanoparticles with average sizes of 43, 71, and 106 nm were prepared using the complex of nickel formate with several chain lengths of alkylamines such as oleylamine (=(Z)-9-octadecenylamine), myristylamine (=tetradecylamine), and laurylamine (=dodecylamine), respectively. The relationship between the magnetic properties and the particle sizes of Ni nanoparticles is discussed.
Design of Sophisticated Bidentate Lewis Acids and Organocatalysts for Fine Organic Synthesis
Authors: Maruoka Keiji 
Published: August 2009

Abstract
Apart from enzymes as biocatalysts, a broad repertoire of chiral reagents, auxiliaries, and catalysts have been developed in recent years. In this respect, the design of new catalysts and new reactions in an efficient manner is increasingly important in this century for the construction of new and useful molecules. Accordingly, by designing and synthesizing sophisticated metal and non-metal catalysts, hitherto unattainable, unusual reactivity and selectivity is pursued in synthetic organic reactions. For example, the rational design of designer Lewis acids, particularly bidentate Lewis acid catalysts and their application to selective organic synthesis is carried out. In addition, the design of chiral phase transfer catalysts, chiral bifunctional organocatalysts, and chiral Brønsted acid catalysts as promising organocatalysts is realized for their application to practical asymmetric synthesis.
Chemistry of Anthracene–Acetylene Oligomers. XIII. Synthesis, Structures, and Spectroscopic Properties of All Possible 1,8-Anthrylene Cyclic Tetramers with Acetylene and Diacetylene Linkers
Authors: Toyota Shinji , Miyahara Hiroaki , Goichi Michio , Yamasaki Shingo , Iwanaga Tetsuo 
Published: August 2009

Abstract
All the possible 1,8-anthrylene cyclic tetramers with acetylene and diacetylene linkers were synthesized as new types of π-conjugated compounds. Building units were connected by coupling reactions, and macrocyclization of the tetrameric precursors by Eglinton coupling gave the desired cyclic oligomers. Molecular structures examined by X-ray analysis and DFT calculations with the M05 functional revealed diamond prism structures with intramolecular contacts between facing anthracenes at ca. 3.5 Å. Restricted dynamic processes between the diamond forms were observed by VT 1H NMR measurements of the cyclic tetramer with one diacetylene linker and the Cs symmetric isomer with two diacetylene linkers. The enantiomers of three chiral cyclic tetramers were resolved by spontaneous resolution or chiral HPLC, and their chiroptical properties were investigated by CD spectroscopy. Absorption and emission spectra and NMR chemical shifts of these oligomers are discussed in terms of the molecular structures.
Self-Consistent Cluster Approximation Analysis of the OH Stretching Bands of Methanol in the Liquid State
Authors: Kanesaka Isao 
Published: August 2009

Abstract
The isotropic and anisotropic Raman spectra and the infrared spectrum of O–H stretching bands of CH3OH in the liquid state are analyzed on the basis of a self-consistent cluster theory based on Green’s function. The observed spectra are explained well in terms of three clusters constructed by combining two intrinsic modes. The probability of the higher and lower intrinsic modes is 0.28 and 0.72, respectively. Two intrinsic modes derived are 3425.5 and 3320.1 cm−1, where the former is recognized for the first time, and they are assigned to a H-bonded OH stretching perturbed by an OH stretching in the other chain or a Y junction and that remains unperturbed, respectively. A weak band at 3529.2 cm−1 found also for the first time is assigned to a local mode in a chain end. Overtones of the OH stretching are satisfactorily explained by fundamentals derived here. The molecules in a chain are evaluated to be 17 with mainly a tetrahedral configuration about the H-bond. In a symmetric cluster a line shape of component bands is asymmetric and their peak positions and bandwidths are discussed with a boundary parameter.
Quasi-Classical Trajectory Dynamics Study on the Reaction of H with HO2
Authors: Mousavipour Seyed Hosein , Yousefiasl Issa 
Published: August 2009

Abstract
Quasi-classical trajectory (QCT) simulations, based on our previously reported PES data (Bull. Chem. Soc. Jpn.2007, 80, 1901) were carried out to study the dynamics of the lowest singlet potential energy surface of H + HO2 reaction. The surface consists of two potential wells due to formation of water oxide (H2OO*) and hydrogen peroxide (HOOH*). A detailed consideration of the dynamics of the intermediates H2OO* and HOOH* reveals that water oxide and hydrogen peroxide geometries, largely undergo asymmetric or symmetric stretching like motions until they dissociate. The QCT calculations revealed that the reaction is very sensitive to the vibrational excitation of HO2. In general, QCT integral, reactive reaction cross-sections and rate constants are found to be in good agreement with their QM and experimental counterparts, indicating that, for this system, the motion of the nuclei during reactive encounters is largely classical and that quantum effects, such as tunneling, play a relatively minor role in the overall dynamics. The intramolecular vibrational energy redistribution (IVR) involving excitation of the OH and OO bonds in HOOH is investigated. The calculated IVR time constants describing energy flow out of the OH and OO stretching modes are reported. It is found that calculated IVR time constants decrease exponentially with increasing the amount of energy put in the relevant modes.
Electronic Structure of Yttrium and Carbon Atoms Encapsulated Metallofullerenes, Y2C2@C82: Ultraviolet Photoelectron Spectroscopy and Theoretical Calculation
Authors: Hino Shojun , Miyazaki Takafumi , Aoki Yusuke , Wanita Norihiko , Kato Masayuki , Sumii Ryohei , Akachi Takao , Inoue Takeshi , Ito Yasuhiro , Sugai Toshiki , Shinohara Hisanori 
Published: August 2009

Abstract
Ultraviolet photoelectron spectra (UPS) of two yttrium atoms and two carbon atoms encapsulated metallofullerenes, Y2C2@C82 were measured using a synchrotron radiation light source. Their upper valence band UPS differ significantly from each other, while the lower valence band ones are almost the same. The UPS of Y2C2@C82 (II) could be well reproduced by simulated spectra obtained with a Gaussian 03 program module assuming a distorted Y2C2 tetragonal form in C2v C82 cage structure.
Semiquantal Valence-Bond Wave Packet Description of Chemical Bonding
Authors: Ando Koji 
Published: August 2009

Abstract
A semiquantal wave packet modeling of electrons in chemical bonding is presented. It is based on the valence bond (VB) theory with non-orthogonal floating and breathing spherical Gaussian orbitals, simplified to treat many electrons by decoupled electron pair approximations (DPA) and core pseudopotentials (CPP). The extended Hamiltonian formalism offers pictorial interpretation and analysis in the extended phase space of the wave packet center and width coordinates. The numerical calculations are demonstrated on the ground state potential energy surfaces of H2, LiH, and BeH2. For LiH, the perfect-pairing VB (VB-PP) calculation with the minimal orbitals gives an accurate potential energy curve of comparable quality with a correlated ab initio calculation. The two-electron VB calculation with a CPP underestimates the binding energy but gives qualitatively correct potential energy curves. For BeH2, the VB-PP with CPP gives reasonably accurate potential energy surface along both the stretching and bending coordinates. A few versions of DPA are developed and assessed, aiming toward large scale dynamic simulations. A scaling ansatz is introduced and examined on the bonding potential energy surfaces. The efficacy of the theory for studying linear and nonlinear electronic polarizations is also illustrated via an analysis of potential energy surfaces in the extended phase space.
A Novel Bi-Metal NiIICdII Supramolecular Structure with 4-Hydroxypyridine Ligands, [{CdII(4-OHpy)2}{NiII(CN)4}], and Deprotonated 3-Hydroxypyridine Ligands, [{CdII3(3-O−py)2(mea)2}{NiII(CN)4}2]
Authors: Kosone Takashi , Suzuki Yusuke , Kitazawa Takafumi 
Published: August 2009

Abstract
Synthesis and crystal structures of new bimetallic polynuclear complexes in 2-dimensional (2D) architectures, [{CdII(4-OHpy)2}{NiII(CN)4}] (4-OHpy = 4-hydroxypyridine) (1) and [{CdII3(3-O−py)2(mea)2}{NiII(CN)4}2] (3-O−py = pyridin-3-onato anion, mea = monoethanolamine) (2) are described. These compounds are prepared by the same method. However, hydroxypyridine ligands are different, thus these structures differ.
Photolabile Protecting Group Bonded to Aminopropyl Silica-Gel Beads
Authors: Matsumoto Jin , Senda Yoshiya , Masuda Hiroki , Fuchikawa Tomokazu , Shiragami Tsutomu , Yasuda Masahide 
Published: August 2009

Abstract
4,5-Dimethoxy-2-nitrobenzyloxycarbonyl group acting as a photolabile protecting group was bonded on 3-aminopropyl silica gels through a covalent bond in a 46% yield. The deprotection was performed under UV-irradiation. The resulting amino group was analyzed through the use of a confocal laser-scanning microscope using 4-(10,15,20-triphenylporphyrinyl)phenyl fluorophore.
Raman Spectra of Isotope-substituted Mitochondria of Living Budding Yeast Cells: Possible Origin of the “Raman Spectroscopic Signature of Life”
Authors: Onogi Chikao , Torii Hajime , Hamaguchi Hiro-o 
Published: August 2009

Abstract
The 13C and 2H isotope substitution effects have been examined for the “Raman spectroscopic signature of life,” a mitochondrial Raman band at 1602 cm−1 that sharply reflects the metabolic activity of living yeast cells. The band shifts to 1542 cm−1 with 13C substitution and to 1599 cm−1 with 2H substitution. Normal mode analysis based on a DFT calculation suggests that it originates from a C=C double bond having no hydrogen atoms attached to the carbon atoms. The in-phase C=C stretch mode of ubisemiquinone radicals (CoQ and/or CoQH•) emerges as a strong candidate for the origin of the 1602 cm−1 band.
Identification of collagen IV derived danger/alarm signals in insect immunity by nanoLC-FTICR MS
Authors: Altincicek Boran , Berisha Arton , Mukherjee Krishnendu , Spengler Bernhard , Römpp Andreas , Vilcinskas Andreas 
Published: August 2009

Abstract
The immune system can be stimulated by microbial molecules as well as by endogenously derived danger/alarm signals of host origin. Using the lepidopteran model insect Galleria mellonella, we recently discovered that fragments of collagen IV, resulting from hydrolysis by microbial metalloproteinases, represent danger/alarm signals in insects. Here, we characterized immune-stimulatory peptides generated by thermolysin-mediated degradation of collagen IV using nanospray ionization Fourier transform ion cyclotron resonance mass spectrometry (FTICR MS) after separation by nanoscale liquid chromatography (nanoLC). The combination of FTICR MS analysis and de novo peptide sequencing resulted in the identification of 38 specific collagen IV fragments of which several peptides included the integrin-binding motif RGD/E known from numerous mammalian immune-related proteins. Custom-synthesized peptides corresponding either to the presently identified collagen peptide GIRGEHyp or to a well-known integrin-binding RGD peptide (GRGDS) were injected into G. mellonella to determine their immune-stimulatory activities in vivo. Both peptides stimulated immune cells and systemically the expression of lysozyme and a specific inhibitor of microbial metalloproteinases. Further examination using specific MAP kinase inhibitors indicated that MEK/ERK and p38 are involved in RGD/E-mediated immune-signaling pathways, whereas JNK seems to play only a minor role.
Auf dem Weg zu einer generischen Architektur für die adaptive Mensch-Maschine-Interaktion im KraftfahrzeugTowards a Generic Adaptability Framework for Automotive HMI
Authors: Heimgärtner Rüdiger 
Published: August 2009

Zusammenfassung
Die Reduktion der mentalen Belastung des Fahrers in gefährlichen Verkehrssituationen erfordert eine automatische Anpassung der Mensch-Maschine-Interaktion (MMI) im Kraftfahrzeug (KFZ). Überdies kann die funktionale Komplexität heutiger Fahrerinformations- und Fahrerassistenzsysteme ohne den Einsatz adaptiver Mechanismen vom Fahrer alleine auf manuelle Art und Weise nicht mehr bewältigt werden. Im globalen Kontext wird auch eine Anpassung an kulturelle Unterschiede in der MMI gefordert. Dazu müssen die kulturellen Präferenzen der Benutzergruppen ermittelt werden. Adaptive Systeme im KFZ sollten ihr Look und Feel automatisch an die Bedürfnisse des Fahrers sowie an die Fahrsituation anpassen, welche jeweils kulturellen Rahmenbedingungen unterliegen.Die umsichtige Gestaltung einer entsprechenden Architektur für derartige adaptive Systeme unter Verwendung von Methoden interkulturellen Usability Engineerings kann dazu beitragen, die Probleme, welche aus adaptiven Mechanismen entstehen, zu bewältigen. Dazu wird der Weg der Architekturgenerierung hin zu einem generischen Adaptivitäts-Framework (GAF) für die MMI im KFZ aufgezeigt.
Was bringt ein Pageflip in Online-Katalogen dem Produktmarketing?What′s in it for Product Marketing when Using a Pageflip in Online-Catalogues?
Authors: Schulte Frank P. , Heineken Edgar , Gall Simon 
Published: August 2009

Zusammenfassung
Produktkataloge spielen im Online-Marketing eine wichtige Rolle. Welchen Effekt ein ”Pageflip“ bei der Darbietung von Information in Online-Katalogen auf die Verarbeitung der Kataloginhalte hat, wird in einem Online-Experiment untersucht. Der Pageflip erlaubt es dem User, jede Seite im Katalog durch eine Drag and Drop-Mausgeste umzublättern, wobei das Umblättern der Seite gleichzeitig visuell rückgemeldet wird. An einer Stichprobe von 210 Versuchsteilnehmern wird in einer zweifaktoriellen Zufallsgruppenanordnung ermittelt, welchen Effekt die Visualisierung des Umblätterns (mit und ohne Visualisierung) auf der einen Seite und die Art des aktiven Umblätterns (Umblättern per Mausklick und Umblättern per Drag and Drop) auf der anderen Seite auf das Behalten der Kataloginhalte hat. Die erhobenen Daten zeigen, dass beide Faktoren die Verarbeitung der Kataloginformation fördern und dass Kataloginhalte deutlich besser behalten werden, wenn sie in einem Online-Katalog mit Pageflip als in einem herkömmlichen Online-Katalog mit statischen Seiten dargeboten werden. Die Befunde werden im Zusammenhang mit der effektiveren Enkodierung der featurereichen Pageflip-Seiten und der mit dem aktiven Umblättern der Seiten verbundenen Aktivierung von Aufmerksamkeitsressourcen diskutiert.
Investigation of the Adhesion of Electroless Copper to Glass Substrates
Authors: Cui Xiaoyun , Hutt David A. , Conway Paul P. 
Published: August 2009

ABSTRACTThis paper reports the effect of a Pd/Sn catalyst treatment process on the adhesion of electroless copper deposited onto a glass substrate. Adhesion of the copper varied with catalyst treatment time: short or extended catalyst immersion times led to lower adhesion. In this work silanisation of the glass surface with (3-aminopropyl)-trimethoxysilane was used to provide a layer of functional molecules to assist the adhesion of the Pd/Sn catalyst. Surface analysis of the catalyzed glass was carried out by X-ray Photoelectron Spectroscopy (XPS) and together with Time-of-Flight Secondary Ion Mass Spectrometry, showed that the Pd/Sn structures changed with increasing immersion time in the catalyst bath. The Pd XPS core level peaks indicated that Pd(0) became more significant in the catalyst layer than Pd(II) with increasing immersion time. Tape peel testing was used to assess the adhesion of the coatings: thin layers adhered well to the glass, but for layers thicker than 160 nm tape tests removed large areas. The failure surfaces of copper layers peeled off the glass were also examined by XPS which indicated that the failure occurred between the copper and catalyst.
Influence of Structure on the Magnetism of Fe1-xAlx Alloys
Authors: Apiñaniz Estibaliz , Martín-Rodriguez Damian , Legarra Estibaliz , Garitaonandia J. Javier Saiz , Plazaola Fernando 
Published: August 2009

AbstractWith the aim of studying the relationship between structure and magnetism of Fe1-xAlx alloys, annealed and as-crushed samples with 0.25x0.425 been studied. X-rays and Mössbauer spectra show that the nearest neighborhood of each Fe atom plays a major role when determining the magnetic behavior of each Fe atom. In fact, these techniques allow us to determine in which surroundings these Fe atoms will behave paramagnetically. On the other hand, the influence of the lattice parameter has also been studied.
Dissipative Particle Dynamics Studies on the Self-Assembling Dynamics of the Peptide Amphiphiles
Authors: Seki Taiga , Arai Noriyoshi , Ozawa Taku , Shimada Tomoko , Yasuoka Kenji , Hotta Atsushi 
Published: August 2009

ABSTRACTA coarse-grained model of peptide amphiphiles (PA) dissolved in aqueous solution was presented, where the effects of PA concentration, temperature and shear stress upon the self-assembly of PA were numerically studied by dissipative particle dynamics (DPD) simulation. We technically investigate the repulsion parameter aHW which indicates the repulsion force between the hydrophilic head of PA and water molecules, hence, at the same time, indicating the change in temperature. It was found that aHW played an important role in the self-assembly dynamics and in the resulting micro-structures of PA. By imposing shear strain on the simulation system, the formation of wormlike PA micelles was accelerated. The simulation results were in good agreement with our previous experimental results and the mechanism of shear-induced transition was proposed.