bluuebunny/crossref_metadata_2025_split huggingface dataset:
The interaction between cerebrovascular disease and neuroticism in late‐life depression: a cross‐sectional study
Authors: Wouts L. , Janzing J.G. , Lampe I.K. , Franke B. , de Vegt F. , Tendolkar I. , van Iersel M.B. , Buitelaar J.K. , Oude Voshaar R.C. 
Published: July 2010

AbstractObjectiveVascular disease and neuroticism are both risk factors for late‐life depression. In this study we examined the interaction between vascular disease and neuroticism as determinants of clinically relevant depressive symptoms (CRDS) in late‐life.MethodsMultivariate logistic regression in a survey of 1396 population‐dwelling people aged ≥70 years. CRDS were defined as scoring ≥16 on the CES‐D. Vascular disease was categorised into four levels: none, ≥2 vascular risk factors, cardiac disease or stroke.ResultsNeuroticism was strongly associated with CRDS in women (OR: 1.6, 95% CI: 1.4–1.8). In men vascular disease interacted negatively but significantly with neuroticism (cardiac disease by neuroticism: OR: 0.8, 95% CI: 0.6–0.9; stroke by neuroticism: OR: 0.8, 95% CI: 0.6–0.96) when predicting CRDS.ConclusionsIn men vascular disease attenuates the predictive value of neuroticism in CRDS, which might be mediated by apathy caused by cerebrovascular disease. Copyright © 2010 John Wiley & Sons, Ltd.
Relevance of a scoring system including CD11c expression in the identification of splenic diffuse red pulp small B‐cell lymphoma (SRPL)
Authors: Baseggio L. , Traverse‐Glehen A. , Callet‐Bauchu E. , Morel D. , Magaud J.P. , Berger F. , Salles G. , Felman P. 
Published: July 2010

Abstract‘Splenic red pulp lymphoma with numerous basophilic villous lymphocytes’ (SRPL), recently described, is characterized by clinical, morphologic, immunologic, cytogenetic and molecular features distinct from SMZL/SLVL and HCL. In particular, the intensity of CD11c staining (expressed as fluorescence intensity ‐RFI‐) in SRPL is significantly different from the RFI in SMZL/SLVL and HCL. Moreover the use of a scoring system based on the expression of CD11c, CD22, CD76, CD38 and CD27 appears to improve the differential diagnosis between SRPL and SMZL/SLVL and emphasizes that SRPL is an entity closed to but distinct from SMZL/SLVL. Copyright © 2010 John Wiley & Sons, Ltd.
Modulators of cancer cell invasiveness
Authors: Kan Jean S. , DeLassus Gregory S. , D'Souza Kenneth G. , Hoang Stanley , Aurora Rajeev , Eliceiri George L. 
Published: July 2010

AbstractCell invasiveness is essential for cancer metastasis. Many proteins, and more recently also non‐coding RNAs, particularly microRNAs (miRNAs), have been reported to affect the cell invasiveness of various cancers. There is an apparent gap between the high number of these macromolecules and the low number of signaling pathways experimentally verified to control cancer invasiveness. We have brought together these various proteins and RNAs because we could not find any publication that filled this important gap. We have noted 589 proteins, 28 miRNAs, and 1 long non‐coding RNA that are reported to modulate invasiveness in cells of various cancers. Interestingly, 44 proteins enhance invasiveness in cells of some cancers, but suppress it in cells of others. Almost all of the proteins that show experimentally verified activation/inhibition effects on, or binding interactions with, each other are linked together in a single network, in a “hub‐and‐spoke” architecture. The accumulated data show trends that point to anticipated future results and highlight gaps in what is known about invasiveness signaling. Identification of cancer invasiveness signaling networks is important for combination and personalized targeted therapies of cancers. J. Cell. Biochem. 111: 791–796, 2010. © 2010 Wiley‐Liss, Inc.
Ring‐chain tautomerism in 2,2‐bis(2‐thienyl)tetrahydrofurans: preparation of [butene‐2H5]‐tiagabine
Authors: Herbert John M. , Mathers Trevor W. 
Published: July 2010

AbstractA concise preparation of [butene‐2H5]‐tiagabine hydrochloride starting from [2H6]‐γ‐butyrolactone is described. It was necessary to ring‐open the labeled γ‐butyrolactone precursor before the addition of 2‐thienyllithium to avoid cyclisation of the intermediate to a 2,2‐bis(2‐thienyl)tetrahydrofuran. Copyright © 2010 John Wiley & Sons, Ltd.
A novel method for stereospecific fluorination at the 2′‐arabino‐position of pyrimidine nucleoside: synthesis of [18F]‐FMAU
Authors: Turkman Nashaat , Gelovani Juri G. , Alauddin Mian M. 
Published: July 2010

AbstractDirect fluorination of a pyrimidine nucleoside at the 2′‐arabino‐position has been deemed to be extremely difficult, if not impossible. The conventional synthesis of 2′‐deoxy‐2′‐fluoro‐5‐methy‐1‐β‐D‐arabinofuranosyluracil (FMAU) and its 5‐substituted analogs involves stereospecific fluorination of the 1,3,5‐tri‐O‐benzoyl‐α‐D‐ribofuranose‐2‐sulfonate ester followed by bromination at the C1‐postion, and then coupling with pyrimidine‐bis‐trimethylsilyl ether. Several radiolabeled nucleoside analogs, including [18F]FMAU, and other 5‐substituted analogs, were developed according to this methodology. However, routine production of these compounds using this multi‐step process is inconvenient and limits their clinical application. We developed a novel precursor and method for direct fluorination of preformed nucleoside analogs at the 2′‐arabino position, exemplified via radiosynthesis of [18F]FMAU. The 2′‐methylsulfonyl‐3′,5′‐O‐tetrahydropyranyl‐N3‐Boc‐5‐methyl‐1‐β‐D‐ribofuranosiluracil was synthesized in multiple steps. Radiofluorination of this precursor with K18F/kryptofix produced 2′‐deoxy‐2′‐[18F]fluoro‐3′,5′‐O‐tetrahydropyranyl‐N3‐Boc‐5‐methyl‐1‐β‐D‐arabinofuranosiluracil. Acid hydrolysis followed by high‐performance liquid chromatography purification produced the desired [18F]FMAU. The average radiochemical yield was 2.0% (decay corrected, n=6), from the end of bombardment. Radiochemical purity was >99%, and specific activity was >1800 mCi/µmol. Synthesis time was 95–100 min from the end of bombardment. This direct fluorination is a novel method for synthesis of [18F]FMAU, and the method should be suitable for production of other 5‐substituted pyrimidine analogs, including [18F]FEAU, [18F]FIAU, [18F]FFAU, [18F]FCAU, and [18F]FBAU. Copyright © 2010 John Wiley & Sons, Ltd.
Significance of the resection of ovarian metastasis from colorectal cancers
Authors: Fujiwara Ayako , Noura Shingo , Ohue Masayuki , Shingai Tatsushi , Yamada Terumasa , Miyashiro Isao , Ohigashi Hiroaki , Yano Masahiko , Ishikawa Osamu , Kamiura Shoji , Tomita Yasuhiko 
Published: July 2010

AbstractBackgroundThe incidence of ovarian metastases from colorectal cancers (CRCs) has been reported to occur in 3–8% of CRC patients, and the prognosis for patients is very poor. We assessed the clinicopathological characteristics of CRC patients with ovarian metastasis and the significance of the resection of ovarian metastases.MethodsWe retrospectively analyzed 22 CRC patients with ovarian metastases. Synchronous ovarian metastases occurred in 8 patients and metachronous ovarian metastases occurred in 14 patients. Peritoneal dissemination was observed in nine patients.ResultsThe mean follow‐up period was 45.3 months. The overall survival at 3 years following diagnosis of ovarian metastases is estimated to be 51.1% and 43.8% at 5 years. The overall survival at 5 years in the group of patients without peritoneal disseminations was 77.9%, which is significantly longer than that of the patients with disseminations (0%) (P = 0.0009). An R0 resection of metastatic sites was achieved in 15 patients and was associated with a significant increase in survival time (P = 0.0002).ConclusionsOur study shows that aggressive resection of ovarian metastases from CRCs is associated with better overall survival. Peritoneal dissemination is an adverse prognostic factor, but R0 resection significantly improves the overall survival of these patients. J. Surg. Oncol. 2010;102:582–587. © 2010 Wiley‐Liss, Inc.
Herringbone‐grooved bearing with non‐uniform grooves for high‐speed spindle
Authors: Ikeda Shinichi , Arakawa Yo , Hishida Noriaki , Hirayama Tomoko , Matsuoka Takashi , Yabe Hiroshi 
Published: July 2010

AbstractA hydrodynamic bearing with non‐uniform herringbone grooves has been developed for use with high‐speed motor spindles. The grooves gradually become narrower, shallower and less straight (curved) towards the herringbone centre along axial direction, resulting in an increased pumping effect of the spiral grooves. The optimum dimensions of the grooves for increasing the critical bearing number were clarified theoretically, and bearings with non‐uniform herringbone grooves were found to increase the critical bearing number against the half‐frequency whirl up to about 50% in comparison to bearings with uniform herringbone grooves. Experiments to investigate the suitability of the proposed bearing for high‐speed spindles showed that the maximum rotational speed of a spindle with this bearing was about 20% higher, close to the theoretically predicted 23%, and thus proved that application of this bearing should enable spindles to achieve faster stable rotation as theoretically expected. Copyright © 2010 John Wiley & Sons, Ltd.
Effect of Mo content on electrochemical behaviour of TiMo alloys for dental applications
Authors: Mareci D. , Chelariu R. , Gordin D. M. , Romas M. , Sutiman D. , Gloriant T. 
Published: July 2010

AbstractCorrosion behaviour of the new TiMo alloys together with the currently used metallic biomaterials commercial pure titanium (Cp‐Ti) was investigated for dental applications. Ingots of composition Ti12Mo, Ti20Mo and Ti40Mo were synthesized by the cold crucible levitation melting (CCLM) technique. All the samples were examined using electrochemical techniques: open circuit potential, potentiodynamic polarization curves and electrochemical impedance spectroscopy (EIS) in two electrochemical media: artificial saliva and in commercial mouthwash solution with 450 ppm F− (Astera©, EU), at 25 °C. The passive behaviour for all the Ti samples is observed for artificial saliva and for commercial mouthwash solution. The results suggest a non‐predominant fluoride effect on the passive behaviours of titanium samples. The EIS technique was applied to study the nature of the passive film formed on all the samples at various potentials in artificial saliva and in commercial mouthwash solution. Equivalent circuits (EC) were used to modelling EIS data, in order to characterize samples surface and better understanding the effect of Mo addition on the Cp‐Ti. The TiMo alloys, with a dendritic arrangement, appear to possess superior corrosion resistance than the Cp‐Ti in both electrochemical media.
Corrosion resistance of low‐nickel duplex stainless steel rebars
Authors: Bertolini L. , Gastaldi M. 
Published: July 2010

AbstractThe use of stainless steel bars in reinforced concrete structures may be an effective method to prevent corrosion in aggressive environments where high amounts of chlorides may penetrate in the concrete cover. For an estimation of the service life of structures where stainless steel bars are used, the chloride threshold for these rebars should be defined, and the influence of chemical composition and metallurgical factors that may affect the corrosion resistance (strengthening, welding, etc.) should be assessed. To reduce the cost of stainless steel reinforcement, duplex stainless steels with low nickel content have been recently proposed as an alternative to traditional austenitic steels, even though, few results are available regarding their corrosion performance in chloride contaminated concrete. This paper deals with the corrosion resistance of low‐nickel duplex stainless steel rebars (1.4362 and 1.4162) as a function of the chloride content. Comparison is made with traditional austenitic steels. An attempt to define a chloride threshold for the different stainless steels is made by comparing the results of several test procedures both in concrete and in solution.
Impedance spectroscopy: An efficient tool to determine the non‐steady‐state chloride diffusion coefficient in building materials
Authors: Sánchez I. , López M. P. , Ortega J. M. , Climent M. Á. 
Published: July 2010

AbstractOne of the most important problems of reinforced steel concrete in marine environments is the corrosion of the reinforcing bars. Most of the times, this corrosion is a consequence of the local destruction of the passive layer formed on the surface of the embedded steel, due to the arrival of chlorides present in the environment. Many efforts have been made to determine the chloride diffusion coefficient in concrete structures, both using natural diffusion methods, and accelerated migration methods. This coefficient determines the velocity of ingress of chlorides, and as a consequence the life time of the structures. In this work it is presented the possibility of using the technique of impedance spectroscopy, that is, very simple to use and requires no chemical or conductivity measurement, to determine the value of the non‐steady‐state diffusion coefficient. This technique, together with the equivalent circuits proposed for the interpretation of the measurements, allows the determination of the chloride saturation of a concrete or mortar sample. Pores of the material that are initially filled with water have high resistivity, and as the chlorides penetrate into the sample the value of the resistivity decreases. This diminution can be determined in situ, and permits the calculation of the diffusion coefficient saving experimental time and efforts. The results have been obtained both with concrete and mortar samples, and using different cement types.
Characterization of tissue structure at varying length scales using temporal diffusion spectroscopy
Authors: Gore John C. , Xu Junzhong , Colvin Daniel C. , Yankeelov Thomas E. , Parsons Edward C. , Does Mark D. 
Published: July 2010

AbstractThe concepts, theoretical behavior and experimental applications of temporal diffusion spectroscopy are reviewed and illustrated. Temporal diffusion spectra are obtained using oscillating‐gradient waveforms in diffusion‐weighted measurements, and represent the manner in which various spectral components of molecular velocity correlations vary in different geometrical structures that restrict or hinder free movements. Measurements made at different gradient frequencies reveal information on the scale of restrictions or hindrances to free diffusion, and the shape of a spectrum reveals the relative contributions of spatial restrictions at different distance scales. Such spectra differ from other so‐called diffusion spectra which depict spatial frequencies and are defined at a fixed diffusion time. Experimentally, oscillating gradients at moderate frequency are more feasible for exploring restrictions at very short distances which, in tissues, correspond to structures smaller than cells. We describe the underlying concepts of temporal diffusion spectra and provide analytical expressions for the behavior of the diffusion coefficient as a function of gradient frequency in simple geometries with different dimensions. Diffusion in more complex model media that mimic tissues has been simulated using numerical methods. Experimental measurements of diffusion spectra have been obtained in suspensions of particles and cells, as well asin vivoin intact animals. An observation of particular interest is the increased contrast and heterogeneity observed in tumors using oscillating gradients at moderate frequency compared with conventional pulse gradient methods, and the potential for detecting changes in tumors early in their response to treatment. Computer simulations suggest that diffusion spectral measurements may be sensitive to intracellular structures, such as nuclear size, and that changes in tissue diffusion properties may be measured before there are changes in cell density. Copyright © 2010 John Wiley & Sons, Ltd.
B0 inhomogeneity‐insensitive triple‐quantum‐filtered sodium imaging using a 12‐step phase‐cycling scheme
Authors: Fleysher Lazar , Oesingmann Niels , Inglese Matilde 
Published: July 2010

AbstractTriple‐quantum‐filtered (TQF) sodium MRI can be used to separate sodium NMR signals from different physiological compartments. Although three‐pulse triple‐quantum filtering has been demonstrated to be better suited for in vivo imaging, the absence of the refocusing pulse in the filter increases its sensitivity to magnetic field inhomogeneities. Therefore, several TQF cycles have been developed previously to correct image distortions caused by B0 inhomogeneities. In this paper, we present a new 12‐step phase‐cycling TQF scheme based on three radiofrequency pulses which allows the compensation of B0 variations both with and without ancillary B0 map information. The method offers 40% higher signal‐to‐noise‐ratio efficiency compared with the previously developed B0‐correcting phase‐cycling schemes. Copyright © 2010 John Wiley & Sons, Ltd.
Water effect on the rheologic behavior of PAN solution during thermal‐induced gelation process
Authors: Tan Lianjiang , Pan Ding , Pan Ning 
Published: July 2010

AbstractThe thermal‐induced gelation process in a polyacrylonitrile (PAN) solution containing different amounts of water was investigated through both dynamic and steady‐state rheologic measurements. During the cooling process, the storage modulus G′ was found to intersect with the loss modulus G″ at a temperature which can be considered as the incipient gel point Tig. This crossover point increased with the water content in the PAN solution. On the basis of the power law $G'\tilde{G}\tilde{\omega} {}^{n} $ and the relation ${\rm tan}\ \delta = G(\omega )/G^{'}(\omega ) = {\rm tan}(n\pi /2) = {\rm const}$, the loss tangent tan δ was traced with decreased temperature at various oscillation frequencies, and a crossover point was observed at the temperature a little higher than the Tig above for all PAN solutions. The water content might affect the value of the relaxation exponent n via two different mechanisms, that is, hydration decoupling of the pendant nitrile groups in PAN at low water content (2 wt% water) and molecule aggregation at high water content (4 and 6 wt%). Nevertheless, the slight difference in the n values reflects the unique structure of the critical gels irrespective of the water level. The apparent viscosity ηa of either the PAN solution or the PAN gel was found to rise with increased water content and both showed pronounced shear‐thinning behavior. Compared with temperature, the water effect on the apparent viscosity ηa is more significant due to the water‐induced aggregation of the molecular chains. Copyright © 2010 John Wiley & Sons, Ltd.
Chain extension of adipic acid and (or) succinic acid/butanediol polyesters with 2,2′‐(1,4‐phenylene)‐bis(2‐oxazoline) and adipoylbiscaprolactamate combined chain extenders
Authors: Xu Shao Yi , Shi Yan Hong , Zhao Jing Bo , Jiang Sheng Ling , Yang Wan Tai 
Published: July 2010

AbstractThis paper provided an easy and flexible method to synthesize high molecular weight polyesters by polycondensation and chain extension. Low molecular weight polybutylene adipate, polybutylene succinate, and poly(butylene succinate‐co‐butylene adipate) (PBSA) were synthesized through melt condensation polymerization from adipic acid and/or succinic acid with butanediol. The prepolyesters obtained had different amount of COOH and OH terminal groups. Chain extension of them was carried out at 180–240°C using 2,2′‐(1,4‐phenylene)‐bis(2‐oxazoline) and adipoyl biscaprolactamate as combined chain extenders. The influencing factors of the chain extension were studied. At the optimal conditions, chain‐extended polybutylene adipate with Mn up to 39,100, polybutylene succinate with intrinsic viscosity of 0.99 dl/g, and PBSA with intrinsic viscosity from 0.73 to 0.81 dl/g were synthesized. The chain‐extended polyesters were characterized by IR spectrum, 1H NMR spectrum, differential scanning calorimetry, thermogravimetric analysis (TGA), wide angle X‐ray scattering, and tensile test. The thermal analysis showed that chain extension often led to slight decrease of the regularity, the crystallinity, and the melting point. This deterioration of the properties is not harmful enough to impair their thermal properties and obstruct them from being used as biodegradable thermoplastics. The TGA showed that the chain‐extended polyesters were stable with initial decomposition temperature over 354.7°C. The tensile strength of the chain extended PBS and PBSAs with butylene adipate units less than 20 mol% was in the range of 18.95–31.22 MPa. Copyright © 2010 John Wiley & Sons, Ltd.
The impact of resorcinol bis(diphenyl phosphate) and poly(phenylene ether) on flame retardancy of PC/PBT blends
Authors: Liu Shumei , Jiang Lei , Jiang Zhijie , Zhao Jianqing , Fu Yi 
Published: July 2010

AbstractFlame retardancy of bisphenol A polycarbonate (PC)/poly(butylene terephthalate) (PBT) blends was improved by the addition of resorcinol bis(diphenyl phosphate) (RDP) and poly(phenylene ether) (PPO). A PC/PBT blend at 70/30 weight ratio obtained a V‐0 rating by the addition of 10 wt% RDP and 10 wt% PPO. The combination of 5 wt% methyl methacrylate‐butadiene‐styrene tercopolymer (MBS) with 3 wt% ethylene‐butylacrylate‐glycidyl methacrylate tercopolymer (PTW) causes a remarkable increase in toughness of the PC/PBT/RDP blend while maintaining a high rigidity. A detailed investigation of the flame‐retardant action of PC/PBT/RDP and PC/PBT/RDP/PPO blends was performed using thermogravimetric analysis (TGA), Fourier transform infrared spectroscopy (FTIR), TGA‐FTIR, temperature‐programmed pyrolysis/gas chromatography/mass spectrometry (TPPy/GC/MS), and scanning electron microscopy/energy dispersive spectrometer (SEM/EDS). The results demonstrate that RDP induces a higher char yield at ca. 450 °C and synchronously increases the thermal stability of the blend with PPO. The flame‐retardant role of RDP in the condensed phase was discerned from TGA, FTIR, and SEM/EDS of the residues. Copyright © 2010 John Wiley & Sons, Ltd.
Phase separation of polyphosphazene/poly(lactide‐co‐glycolide) blends prepared under different conditions
Authors: Cai Qing , Wang Ying , Yang Fei , Shen Hong , Yang Xiaoping , Wang Shenguo 
Published: July 2010

AbstractUsing a mutual solvent technique, blend films of poly[(alaine ethyl ester)0.62(glycine ethyl ester)0.38]phosphazene/poly(lactide‐co‐glycolide) (PAGP/PLGA blend) were prepared at different conditions including weight ratios, solvents, environmental humidity, film thickness, and substrates. The morphology and properties of blend films were characterized by scanning electron microscope (SEM), energy dispersive spectrometer (EDX), X‐ray photoelectron spectrometry (XPS), and solvent selective etching. Compared with dichloromethane and tetrahydrofuran (THF), chloroform was the better solvent to form miscible PAGP/PLGA blend films at relatively anhydrous atmosphere. However, in the humid atmosphere, the hexagonal arrangement of holes appeared on the surface of PAGP/PLGA blend films due to the ordered array of water droplets. A sandwich‐liked structure was formed with the hydrophilic PAGP component at the top and bottom, while the PLGA component in the middle. In addition, the surface morphology of PAGP/PLGA blend films was also influenced by the film thickness and the property of the substrate. Copyright © 2010 John Wiley & Sons, Ltd.