bluuebunny/crossref_metadata_2025_split huggingface dataset:
Based on knowledge capital value for disease cost accounting of diagnosis related groups
Authors: Duan Jinli , Jiao Feng , Xi Jicheng , Zhang Qichun 
Published: June 2024

BackgroundThe National Health Commission and the other relevant departments in China have initiated testing of the Diagnosis Related Groups (DRGs) system in 30 pilot locations since 2019. In the process of DRG payment reform, accounting for the costs of diseases has become a highly challenging issue. The traditional method of disease accounting method overlooks the compensation for the knowledge capital value of medical personnel.ObjectiveThe primary objective of this study is to analyze the cost accounting scheme of China’s Diagnosis Related Groups (C-DRG), focusing on the value of knowledge capital.MethodsThe study initially proposes a measurement index system for the value of knowledge-based capital, including the difficulty of disease treatment, labor intensity of disease treatment, risk of disease treatment, and operation/treatment time for diseases. The Analytic Hierarchy Process (AHP) is then utilized to weigh the features of medical workers’ knowledge capital value. First, pairwise comparisons are conducted in this stage to develop a two-pair judgment matrix of the primary indicators. Second, the eigenvectors corresponding to the maximum eigenvalues of the matrix are calculated to generate the weight coefficient of each feature. The consistency test is carried out after this stage. An empirical analysis is conducted by collecting data, including the full costs of treating three types of diseases—hip replacement, acute simple appendicitis, and heart bypass surgery—from one public medical institution.ResultsThe empirical analysis examines whether this DRG costing accounting can address the issue of neglecting the value of medical workers’ knowledge capital. The methods reconfigure the positive incentive mechanism, stimulate the endogenous motivation of the medical service system, foster independent changes in medical behavior, and achieve the goals of reasonable cost control.ConclusionIn the cost accounting system of C-DRG, the value of medical workers’ knowledge capital is acknowledged. This acknowledgment not only boosts the enthusiasm and creativity of medical workers in optimizing and standardizing the diagnosis and treatment process but also improves the transparency and authenticity of DRG pricing. This is particularly evident in the optimization and standardization of the diagnosis and treatment processes within medical institutions and in monitoring inadequate medical practices within these institutions.
Smoking-diseases correlation database: comprehensive analysis of the correlation between smoking and 422 diseases based on NHANES 2013–2018
Authors: Chen Xi , Wang Tengkun , Tian Yushan , Ma Yinchao , Liu Yuan , Chen Huan , Hou Hongwei , Hu Qingyuan , Chu Ming 
Published: June 2024

BackgroundSmoking is a risk factor for a wide range of diseases. Previous research has confirmed over 30 Smoking-Associated Diseases in diverse systems. There is limited research exploring the correlation among multiple diseases, with an absence of comprehensive investigations. Few studies concentrate on diseases exhibiting a negative correlation with smoking, wherein smokers demonstrate a lower prevalence.ObjectiveThis study aimed to detect the correlation between smoking and other diseases using data from National Health and Nutrition Examination Surveys (NHANES) and construct a Smoking-Diseases Correlation Database (SDCD). The second aim is to obtain an extensive screening test for diseases that may be linked to smoking.Methods39,126 subjects’ data from the NHANES 2013–2018 dataset were extracted. The baseline information, difference in blood routine and blood chemistry indicators between smokers and non-smokers, and diseases’ correlation with smoking in four different models were analyzed by R. The data and statistics were aggregated into an online SDCD.ResultsOur study reported 46 Smoking-Associated Diseases (SAD), including 29 Smoking Positively Associated Diseases (SPAD) and 17 Smoking Negatively Associated Diseases (SNAD). The SDCD of 422 diseases was constructed and can be accessed at https://chatgptmodel.shinyapps.io/sdcd/.ConclusionOur findings revealed 46 SADs including 29 SPADs and 17 SNADs. We aggregated the statistics and developed online SDCD, advancing our understanding of the correlation between smoking and diseases.
A chain mediation model on organizational support and turnover intention among healthcare workers in Guangdong province, China
Authors: Chen Yuanyuan , Xia Ping , Liu Chaojie , Ye Chumin , Zeng Qi , Liang Baofang 
Published: June 2024

IntroductionThe outbreak of the Coronavirus Disease 2019 pandemic has presented significant difficulties for healthcare workers worldwide, resulting in a higher tendency to quit their jobs. This study aims to investigate the correlation between organizational support, work-family-self balance, job satisfaction, and turnover intention of healthcare professionals in China’s public hospitals.MethodsA cross-sectional survey was conducted on 5,434 health workers recruited from 15 public hospitals in Foshan municipality in China’s Guangdong province. The survey was measured by organizational support, work-family-self balance, job satisfaction, and turnover intention using a five-point Likert scale. The association between organizational support, work-family-self balance, job satisfaction, and turnover intention was investigated using Pearson correlation analysis and mediation analysis through the PROCESS macro (Model 6).ResultsOrganizational support indirectly affected turnover intention through three pathways: the mediating role of work-family-self balance, job satisfaction, and the chain mediating role of both work-family-self balance and job satisfaction.ConclusionHealth administrators and relevant government sectors should provide sufficient organizational support, enhance work-family-self balance and job satisfaction among healthcare workers, and consequently reduce their turnover intentions.
The impact of decentralization of health services at the municipal level on health outcomes: evidence from China
Authors: Cui Feng , Wang Shanshan 
Published: June 2024

ObjectivesUnder the system of health decentralization, there are differences in the level of expenditure decentralization at different levels of government, and their impact on residents’ health may also be different. This paper is one of the first to evaluate the effect of decentralization of health services at the municipal level from a multi-dimensional health perspective.Data and methodsThis paper uses the data of expenditure decentralization of health services at the municipal level to match the panel data from the China Household Panel Survey (CFPS) from 2010 to 2018, and uses the logit model, ordered logit model and two-way fixed effects model to empirically analyze the impact of health decentralization at the municipal level on health outcomes.ResultsBased on the perspective of multi-dimensional health, from the three aspects of physical health, depression status and cognitive ability, the six sub-indicators of self-rated health, BMI standards, depression scores (summation method), depression scores (factor method), phrase test scores and mathematics test scores are discussed separately. The results show that the decentralization of health services at the municipal level has a significant promotion effect on the multi-dimensional health of residents.ConclusionThe decentralization of health services at the municipal level has important theoretical significance for promoting the reasonable division of medical and health powers and expenditure responsibilities between provincial and municipal governments, improving the efficiency of health expenditure funds, and establishing a fiscal system that matches financial resources.
Exit interviews from two randomised placebo-controlled phase 3 studies with caregivers of young children with autism spectrum disorder
Authors: Hawken Natalia , Falissard Bruno , Choquet Carl , Francois Clement , Tardu Jean , Schmid Ramona 
Published: June 2024

IntroductionAutism spectrum disorder (ASD) is characterised by difficulty with social communication and restricted, repetitive patterns of behaviour. This study aimed to improve understanding of the ASD patient experience with the treatment (bumetanide) regarding the changes in core symptoms and to assess changes considered as meaningful. To achieve this, qualitative interviews were conducted with caregivers of patients in two phase 3 clinical trials (NCT03715153; NCT03715166) of a novel ASD treatment.MethodsCaregivers were invited to participate in one interview after completion of the pivotal phase 3 study; for those of them who continued treatment after study completion, a second interview was held 3 months after trial completion. The interviews were conducted by qualitative researchers and followed a semi-structured interview guide. The interviews focused on patients’ ASD symptoms and their impact on their daily life before enrolment, and on any symptom changes patients experienced during the trial.ResultsOut of the 13 eligible patients’ caregivers, 11 were interviewed up to two times at clinical sites in the UK, Spain, and Italy. The caregivers reported impairments in a wide range of skills: deficits in communication and social interaction; restricted, repetitive patterns of behaviour, interests, or activities; and cognitive, emotional, and motor impairments. Compared to before the trial initiation, caregivers also reported improvements in the following domains: communication, interaction with others, cognition, aggression, emotions, repetitive movements, eating, and sleeping.ConclusionThe exit interviews provided a rich source of qualitative data, allowing a deeper understanding of caregivers’ and patients’ experience of the disease and allowing us to understand what constitutes a meaningful change. These data also helped identify important experiences that may inform the patient-reported outcome measurement strategy for future trials in ASD.
Carotid endarterectomy using regional anesthesia: technique and considerations
Authors: Padmanaban Varun , Caldwell Catherine , Milne Indigo , Hazard Sprague W. , Harbaugh Robert E. , Church Ephraim W. 
Published: June 2024

BackgroundCarotid endarterectomy (CEA) is one of the most effective operations in minimizing stroke risk in both symptomatic and asymptomatic patients with carotid stenosis in the United States. Awake CEA with regional anesthesia may decrease both perioperative complications and length of hospital stay. Techniques of performing awake CEA is not often described in published literature.ObjectiveTo describe our experience with CEA using regional anesthesia with a focus on patient selection, anatomic variations, and surgical technique including cervical regional block. We particularly focus on nuances of the awake approach.MethodsCEA using regional anesthesia is described in detail.ResultsSuccessful use of regional anesthesia during CEA without complication.ConclusionRegional anesthesia for CEA is an advantageous approach for cervical plaque removal in appropriate patients. Thoughtful patient selection, as well as understanding of anatomy and its variants, is required. Potential advantages and disadvantages are discussed.
Foot and mouth disease vaccine efficacy in Africa: a systematic review and meta-analysis
Authors: Wubshet Ashenafi Kiros , Werid Gebremeskel Mamu , Teklue Teshale , Zhou Luoyi , Bayasgalan Chimedtseren , Tserendorj Ariunaa , Liu Jinjin , Heath Livio , Sun Yuefeng , Ding Yaozhong , Wang Wenxiu , Zaberezhny Alexei D. , Liu Yongsheng , Zhang Jie 
Published: June 2024

BackgroundSeveral factors, such as diverse serotypes, vaccination methods, weak biosecurity, and animal movements, contribute to recurrent Foot-and-Mouth Disease Virus (FMDV) outbreaks in Africa, establishing endemicity. These outbreaks cost over $2 billion annually, prompting a high-priority focus on FMDV vaccination. Despite extensive efforts, vaccine efficacy varies. This study aims to evaluate routine foot and mouth disease (FMD) vaccines in Africa via systematic review and meta-analysis.MethodsA systematic review and meta-analysis were carried out following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Meta-analysis was conducted to assess the efficacy of FMDV vaccination using the meta for package of R.ResultsVaccinated animals have roughly a 69.3% lower chance of FMDV infection compared to unvaccinated animals, as indicated by the pooled results from the random-effects model, which showed a risk ratio (RR) of 0.3073. There was a statistically significant heterogeneity (p &lt; 0.05) across all of the included articles.ConclusionOverall findings suggest that if properly planned and implemented, FMDV vaccination programs and strategies in Africa could help control the spread of the disease throughout the continent and beyond.
Whole-Genome Sequencing of Human and Porcine Escherichia coli Isolates on a Commercial Pig Farm in South Africa
Authors: Strasheim Wilhelmina , Lowe Michelle , Smith Anthony M. , Etter Eric M. C. , Perovic Olga 
Published: June 2024

Escherichia coli is an indicator micro-organism in One Health antibiotic resistance surveillance programs. The purpose of the study was to describe and compare E. coli isolates obtained from pigs and human contacts from a commercial farm in South Africa using conventional methods and whole-genome sequencing (WGS). Porcine E. coli isolates were proportionally more resistant phenotypically and harbored a richer diversity of antibiotic resistance genes as compared to human E. coli isolates. Different pathovars, namely ExPEC (12.43%, 21/169), ETEC (4.14%, 7/169), EPEC (2.96%, 5/169), EAEC (2.96%, 5/169) and STEC (1.18%, 2/169), were detected at low frequencies. Sequence type complex (STc) 10 was the most prevalent (85.51%, 59/169) among human and porcine isolates. Six STcs (STc10, STc86, STc168, STc206, STc278 and STc469) were shared at the human–livestock interface according to multilocus sequence typing (MLST). Core-genome MLST and hierarchical clustering (HC) showed that human and porcine isolates were overall genetically diverse, but some clustering at HC2–HC200 was observed. In conclusion, even though the isolates shared a spatiotemporal relationship, there were still differences in the virulence potential, antibiotic resistance profiles and cgMLST and HC according to the source of isolation.
Design, Synthesis and Bioactivities of Novel Pyridyl Containing Pyrazole Oxime Ether Derivatives
Authors: He Jie , Zhou Beibei , Wang Xinjuan , Chen Qi , Jiang Xiaoqian , Kong Ting , Yao Long , Zhao Yingying , Chen Rong , Xu Ying , Dai Hong 
Published: June 2024

In this research, with an aim to develop novel pyrazole oxime ether derivatives possessing potential biological activity, thirty-two pyrazole oxime ethers, including a substituted pyridine ring, have been synthesized and structurally identified through 1H NMR, 13C NMR, and HRMS. Bioassay data indicated that most of these compounds owned strong insecticidal properties against Mythimna separata, Tetranychus cinnabarinus, Plutella xylostella, and Aphis medicaginis at a dosage of 500 μg/mL, and some title compounds were active towards Nilaparvata lugens at 500 μg/mL. Furthermore, some of the designed compounds had potent insecticidal effects against M. separata, T. cinnabarinus, or A. medicaginis at 100 μg/mL, with the mortalities of compounds 8a, 8c, 8d, 8e, 8f, 8g, 8o, 8s, 8v, 8x, and 8z against A. medicaginis, in particular, all reaching 100%. Even when the dosage was lowered to 20 μg/mL, compound 8s also expressed 50% insecticidal activity against M. separata, and compounds 8a, 8e, 8f, 8o, 8v, and 8x displayed more than 60% inhibition rates against A. medicaginis. The current results provided a significant basis for the rational design of biologically active pyrazole oxime ethers in future.
Exploring the Antibacterial Potential of Lamiaceae Plant Extracts: Inhibition of Bacterial Growth, Adhesion, Invasion, and Biofilm Formation and Degradation in Pseudomonas aeruginosa PAO1
Authors: Oalđe Pavlović Mariana , Kolarević Stoimir , Đorđević Aleksić Jelena , Vuković-Gačić Branka 
Published: June 2024

In response to the global rise in antibiotic resistance and the prevalence of bacterial biofilm-related infections, the antibacterial efficacy of methanolic, ethanolic, and aqueous extracts of 18 Lamiaceae plants from Serbia was evaluated. The total coumarins and triterpenes were detected spectrophotometrically, while a microdilution assay measured their effects on bacterial growth. Additionally, the impact of these extracts was assessed on Pseudomonas aeruginosa PAO1 adhesion and invasion in human fibroblasts and biofilm formation and degradation. The alcoholic extracts had the highest phytochemical content, with Teucrium montanum and Lavandula angustifolia being the richest in coumarins and triterpenes, respectively. Gram-positive bacteria, particularly Bacillus subtilis, were more susceptible to the extracts. Hyssopus officinalis ethanolic and Sideritis scardica methanolic extracts inhibited bacterial growth the most efficiently. Although the extracts did not inhibit bacterial adhesion, most ethanolic extracts significantly reduced bacterial invasion. Origanum vulgare and H. officinalis ethanolic extracts significantly inhibited biofilm formation, while Teucrium chamaedrys extract was the most active in biofilm degradation. This study significantly contributes to the literature by examining the antibacterial activity of Lamiaceae extracts, addressing major literature gaps, and underscoring their antibacterial potential, particularly Satureja montana and O. vulgare ethanolic extracts, linking their efficacy to coumarins and triterpenes.
Pengaruh Berbagai Jenis Pupuk Kandang Terhadap Pertumbuhan Dan Hasil Tanaman Bunga Kol (Brassica olerancea var. botrytis L.) Varietas PM 126 F1
Authors: Purnama Vera , Lusiana Lusiana , Racman Fajar 
Published: June 2024

The research aims to determine the best types of manure for the growth and yield of flower plants (Brassica olerencea var. botrytis L.) PM 126 F1 variety. The research was carried out in Palabuan Hamlet, Sukamelang Village, Subang District, Subang Regency with an altitude of 50 meters above sea level, the research started from June to August 2023. The research was carried out using a Randomized Block Design (RAK) with 8 treatments of various types of manure (Manure). chicken 15 tons/ha, chicken manure 25 tons/ha, cow drum fertilizer 15 tons/ha, cow manure 25 tons/ha, goat manure 15 tons/ha, goat drum fertilizer 25 tons/ha, bat guano manure 15 tons/ha, fertilizer bat guano cages 25 tons/ha) repeated 3 times with a total of 24 plots. The research results showed that various types of manure had an effect on the observation parameters of plant height at 21 HST and 28 HST, leaf area, plant dry weight, flower weight, and flower diameter. Cow manure at a dose of 25 tons/ha produced the best cauliflower weight, namely 207.73 grams.Â Â
PENGARUH BEBERAPA KONSENTRASI PUPUK HAYATI MAJEMUK TERHADAP PERTUMBUHAN DAN HASIL CABAI MERAH BESAR (Capsicum annuum L.) VARIETAS CIKO
Authors: Abdullah Rohana , Supriatna Nana , Mulya Agus Surya 
Published: June 2024

Pemupukan anorganik dalam budidaya pertanian sangat intensif sehingga kesehatan tanah menurun. Penggunaan pupuk hayati menjadi salah satu usaha untuk memulihkan tanah kembali. Tujuan penelitian adalah untuk mempelajari pengaruh beberapa dosis pupuk hayati terhadap pertumbuhan dan hasil tanaman Cabai merah besar (Capsicum Annum L.) Varietas Ciko. Penelitian ini dilaksanakan pada bulan Mei 2023 sampai bulan September 2023 di Kebun Percobaan Fakultas Pertanian Universitas Winaya Mukti, Tanjung Sari, Sumedang. Dengan ketinggian tempat sekitar 850 meter di atas permukaan laut (mdpl). Â Â Rancangan Acak Kelompok (RAK) pola sederhana, kombinasi konsentrasi Pupuk Hayati, dengan 6 taraf percobaan (A = Konsentrasi 0 ml/liter air B = Konsentrasi 5 ml/ liter air, C = dosis 10 ml/liter air, D = dosis 15 ml/liter air, E = dosis 20 ml/liter air, F = dosis 25 ml/liter air) dan diulang sebanyak 4 kali. Hasil penelitian menunjukkan dosis Pupuk Hayati berpengaruh nyata terhadap pertumbuhan tinggi tanaman 2, 4, 6, MST;Â Â jumlah daun 2, 4 , 6, 8 MST; dan bobot per buah padaÂ E dan F.Â Hasil terbaik ditunjukan padaÂ dosis Pupuk Hayati 20 ml/liter airÂ Â terhadapÂ tinggi tanaman umur 2, 4, 6 MST, jumlah daun umur 2, 4 ,6 , 8 MST dan bobot per buah
Geographically Weighted Regression Modeling with Adaptive Gaussian Kernel Weighting on GRDP in Indonesia
Authors: Tangka Frangly Elviano , Hatidja Djoni , Weku Winsy Ch.D 
Published: June 2024

The purpose of this study is to determine the variables that affect Gross Regional Domestic Product (GRDP) in Indonesia in 2022 using Geographically Weighted Regression (GWR) with Adaptive Gaussian kernel weighting function. The data used in this study uses secondary data taken from the website of the Central Bureau of Statistics. The variables used are gross regional domestic product of 34 provinces in Indonesia (Y, in billion rupiah), labor force participation rate (X1, in %), foreign investment (X2, in million dollars), open unemployment rate (X3, in %) and human development index (X4, in %). Data were analyzed using GWR with adaptive gaussian kernel weighting function. GRDP in all provinces on the island of Sumatra (11 provinces), DKI Jakarta province, Banten province, and West Kalimantan province are influenced by foreign investment (X2) and human development index (X4). Meanwhile, GRDP in the other 19 provinces is only influenced by foreign investment (X2). GWR model with adaptive gaussian kernel weighting function is formed differently for each province in Indonesia.
Keywords: Adaptive gaussian kernel; GWR; gross regional domestic product
Publishing activity of the Book Chamber of Ukraine as of 1964
Authors: Doiar Larуsa 
Published: June 2024

The presented article is a continuation of the author's research on the history of the Book Chamber of Ukraine, devoted to the activities of the State Archive of the Press, the Methodical Council and the Editorial and Publishing Department of the institution. Last year's work on this topic was written for the 85th anniversary of the "Chronicle of Journal Articles" and revealed the problem of publishing this state bibliographic index in the Book Chamber of Ukraine. Working in accordance with this year's plan of scientific work, the author researched the publishing activities of the Book Chamber of Ukraine as of 1964. The purpose of this research is to conduct a content analysis of contemporary publications, their classification, identify key areas and priorities. The scientific novelty of the work is to attract underused materials of the internal departmental archive of the institution, elaboration of a rare to date (circulation of less than 4 thousand copies) decadal bibliographic bulletin "New Books of the USSR" in 1964 and personalization of publishing history within the Book Chamber of Ukraine. Following the principles and requirements of scientific methodology, the author relied on general (comparison, measurement (empirical), analysis, synthesis (complex), convergence from abstract to specific (theoretical)) and special (component-analytical, grouping) research methods. The source base for writing the article was the annual notebook of the New Books of the USSR, dated 1964. The content of the work contains a complete list of publications prepared and published by the Book Chamber of the Ukrainian SSR during 1964, and demonstrates their thematic and sectoral diversity. The concluding part of the article testifies to the fact that the publishing activity of the institution flourished as of 1964, arguing that in this case there was a clear Ukraine-centric orientation.