bluuebunny/crossref_metadata_2025_split huggingface dataset:
Emerging roles of long noncoding RNA H19 in human lung cancer
Authors: Ahmad Irfan , Jasim Saade Abdalkareem , Sergeevna Klunko Nataliya , Jyothi.S Renuka , Kumar Ashwani , Dusanov Abdigafur , Shuhata Alubiady Mahmood Hasen , Sinha Aashna , Zain Al‐Abdeen Salah Hassan , Hjazi Ahmed 
Published: June 2024

AbstractLung cancer holds the position of being the primary cause of cancer‐related fatalities on a global scale. Furthermore, it exhibits the highest mortality rate among all types of cancer. The survival rate within a span of 5 years is less than 20%, primarily due to the fact that the disease is often diagnosed at an advanced stage, resulting in less effective treatment options compared to earlier stages. There are two main types of primary lung cancer: nonsmall‐cell lung cancer, which accounts for approximately 80%–85% of all cases, and small‐cell lung cancer, which is categorized based on the specific type of cells in which the cancer originates. The understanding of the biology of this disease and the identification of oncogenic driver alterations have significantly transformed the landscape of therapeutic approaches. Long noncoding RNAs (lncRNAs) play a crucial role in regulating various physiological and pathological processes through diverse molecular mechanisms. Among these lncRNAs, lncRNA H19, initially identified as an oncofetal transcript, has garnered significant attention due to its elevated expression in numerous tumors. Extensive research has confirmed its involvement in tumorigenesis and malignant progression by promoting cell growth, invasion, migration, epithelial‐mesenchymal transition, metastasis, and therapy resistance. This comprehensive review aims to provide an overview of the aberrant overexpression of lncRNA H19 and the molecular pathways through which it contributes to the advancement of lung cancer. The findings of this review highlight the potential for further investigation into the diagnosis and treatment of this disease, offering promising avenues for future research.
Sulfonated Graphene‐Based Materials as Heterogeneous Acid Catalysts for Solketal Synthesis by Acetalization of Glycerol
Authors: Gil‐Gavilán Dolores G. , Amaro‐Gahete Juan , Rojas‐Luna Raúl , Benítez Almudena , Estevez Rafael , Esquivel Dolores , Bautista Felipa M. , Romero‐Salguero Francisco J. 
Published: June 2024

AbstractAcid catalysis plays a pivotal role in the industrial landscape due to its multifaceted contributions to various chemical processes in numerous sectors, including petrochemicals, polymers, food processing, and biodiesel production, among others. Sulfonated graphenes hold notable relevance as heterogeneous acid catalysts due to their unique combination of graphene's structural properties and the introduction of sulfonic groups as catalytic acid sites. Herein, we report the preparation of three sulfonated graphene‐based materials – sulfonated reduced graphene oxide (rGO‐SO3H), chlorosulfonated reduced graphene oxide (rGO‐HSO3Cl) and sulfonated graphene oxide (GO‐SO3H) – by different synthetic approaches. Physicochemical, textural, morphological, and acidic properties of all materials were characterized in detail by different instrumental techniques. Innovatively, these materials have been evaluated as heterogeneous acid catalysts in the solketal synthesis by acetalization of glycerol, which is considered an interesting building block to produce added‐value products. The density of acidic active sites and hydrophobicity were found to be conditioning parameters of the resulting catalytic activity in terms of conversion and selectivity. The best catalytic performance was obtained by rGO‐SO3H, reaching the maximum conversion towards solketal in 15 minutes under mild reaction conditions. The reusability and stability of all materials were also examined after three consecutive acetalization reactions with only a slight loss of catalytic activity.
Modular Assembly and Optimization of an Artificial Esterase from Functionalised Surfactants
Authors: Matich Olivia , Naiya Mohinder Maheshbhai , Salam Joanne , Tiban Anrango Bryan Andres , Chen Jack L.‐Y. 
Published: June 2024

AbstractA strategy for the screening and optimization of an artificial esterase is presented that utilizes the self‐assembly of amphiphilic molecules. Unlike conventional approaches that rely on the attachment of key functional groups onto molecular scaffolds or surfaces, the modular assembly of amphiphiles allows a large number of catalytic combinations to be investigated with minimal synthetic effort. In this study, iterative combinatorial screens led to an optimized esterase comprising amphiphiles that act as a nucleophilic catalyst, an oxyanion hole and a metal ion chelator. Cooperativity is observed between the functional headgroups of the amphiphiles, an effect that is diminished when co‐assembled with non‐functionalized surfactants. Assessment of the catalytic efficiency (kcat/KM) of our optimized catalysts against recently reported artificial esterases shows comparable efficiency, indicating that efficient catalysis is possible with dynamic self‐assembled systems despite the absence of pre‐defined rigid binding pockets.
Lutetium Copper@Hexagonal Boron Nitride Nanocomposite Electrode System for Sensing and Signalling Ciprofloxacin
Authors: Nepfumbada Collen , Mamba Bhekie B. , Bartlett Bart M. , Fernández‐Sánchez Jorge F. , Feleni Usisipho 
Published: June 2024

AbstractHerein, a new electrochemical sensing system based on lutetium copper nanoparticles supported on hexagonal boron nitride (Lu‐Cu@h‐BN) was designed for the sensitive detection of ciprofloxacin (CIP) antibiotic. A simple hydrothermal method was used to synthesize the nanocomposite. The structural and morphological characteristics of the as‐prepared nanocomposite were investigated using various analytical techniques such as Fourier transform infrared spectroscopy (FTIR), X‐ray diffraction (XRD), scanning electron microscopy (SEM), and X‐ray photoelectron spectroscopy (XPS). The newly developed Lu‐Cu@h‐BN nanocomposite was used as an electrode modifier for sensing and signalling of CIP. Cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) were used to study the electrochemical activities of the bare GCE, Cu‐h‐BN/GCE, Lu‐h‐BN/GCE, Lu‐Cu/GCE, and Lu‐Cu@h‐BN/GCE. The electro‐oxidation of CIP on electrode surface exhibited an irreversible, diffusion‐controlled process. The sensor system obtained a wider linear range of (0.05–100 μM) with a lower detection limit value of 0.03 μM and sensitivity 0.7443 μA μM−1 cm−2. Furthermore, the sensor demonstrated an excellent selectivity, good stability, and reproducibility, with acceptable recoveries of 96 % to 104 % in real water sample analysis.
Semi‐Interpenetrating Polymer Network Anion Exchange Membranes Based on Quaternized Polybenzoxazine and Poly(Vinyl Alcohol‐Co‐Ethylene) for Acid Recovery by Diffusion Dialysis
Authors: Tian Longyu , Wang Min , Liao Guangming , Liu Baoliang , Sun Yucheng , Hu Yukun , Lu Zaijun 
Published: June 2024

AbstractAcid recovery from acidic waste is a pressing issue in current times. Chemical methods for recovery are not economically feasible and require significant energy input to save the environment. This study reported a semi‐interpenetrating polymer network (semi‐IPN) anion exchange membranes (AEMs) for acid recovery by diffusion dialysis with excellent dimensional stability, high oxidation stability, good acid dialysis coefficient (UH+) and high separation factor (S). Semi‐IPN AEMs are prepared by ring‐open cross‐linked quaternized polybenzoxazine (AQBZ) with poly(vinyl alcohol‐co‐ethylene), where AQBZ is obtained by Mannich reaction and Menshutkin reaction. All four proportions of semi‐IPNs exhibit clear micro‐phase separation, which is conducive to ion transport. The water uptake (WU) of the four semi‐IPNs ranges from 14.2 % to 19.2 %, while the swelling ratio (SR) remains between 8.7 % and 11.3 %. These results indicate that the cross‐linked structure in the designed semi‐IPNs effectively control swelling and ensure dimensional stability. The thermal degradation temperature (Td5) of semi‐IPN4:6 to semi‐IPN7:3 varies from 309 °C to 289 °C, with an oxidation stability weight loss rate (WOX) ranging from 91.5 % to 93.5 %, demonstrating excellent thermal stability and oxidation stability. The semi‐IPNs also show good UH+ values ranging from 11.9–16.3*10−3 m/h and high S values between 38.6 and 45.9, indicating the promising potential of the semi‐IPNs.
Cellular Effects of Cationic Copper(II) Schiff Base Complexes: Anti‐Inflammatory and Antiproliferative Properties
Authors: Vančo Ján , Trávníček Zdeněk , Malina Tomáš , Hošek Jan , Dvořák Zdeněk 
Published: June 2024

AbstractA series of potassium isothiocyanato‐(N‐salicylidene‐aminoacidato) cuprates (1–5) with the general formula of the monomeric unit K[Cu(sal‐aa)(NCS)] ⋅ xH2O (x=0 or 2), containing a Schiff‐base ligand (H2sal‐aa) derived from natural amino acids such as glycine, DL‐α‐alanine, DL‐valine, DL‐phenylalanine and β‐alanine, and salicylaldehyde, was screened for in vitro antiradical and major cellular effects against selected cancerous and normal cells. The complexes exhibited strong antioxidant properties against superoxide in vitro and a protective effect on DNA under Fenton‐like reaction conditions. Screening of their cellular effects revealed moderate in vitro cytotoxicity against human cancer cell lines (A2780, A2780R and MCF‐7), with IC50 values of 25–35 μM, and relatively low toxicity to normal fibroblast MRC‐5 cells (with IC50 values>50 μM). Additional experiments performed on A2780 cells revealed that the most potent complex 5 significantly increased the number of A2780 cells arrested in the G2/M phase of the cell cycle and triggered intracellular oxidative stress. The selected flow cytometry experiments (detection of apoptosis/autophagy and activation of caspases 3/7 and depletion of mitochondrial membrane potential) did not reveal the dominant mechanism underlying the cytotoxicity of the complexes but clearly differentiated their molecular effects from those of the reference drug cisplatin. All the complexes exerted anti‐inflammatory effects by modulating the levels of the proinflammatory cytokines TNF‐α and IL‐1β in LPS‐activated THP‐1 macrophage‐like cells. Complex 5 also slightly influenced the activity of the upstream NF‐κB transcription factor, while no effect on PPARγ activation was detected.
Thia‐ and Seleno‐Michael Reactions for the Synthesis of Carbonic Anhydrases Inhibitors
Authors: Angeli Andrea , Occhini Alessio , Renzi Gioele , Capperucci Antonella , Ferraroni Marta , Tanini Damiano , Supuran Claudiu T. 
Published: June 2024

AbstractNovel chalcogen‐containing amides and esters bearing the benzenesulfonamide moiety have been synthesised upon nucleophilic conjugate addition of thiols and selenols to suitable electron‐deficient alkenes. The activity of the synthesised compounds as Carbonic Anhydrases inhibitors has been investigated in vitro and the inhibition mechanism has been elucidated by X‐rays studies.
The IMS Library: from IN‐Stock to Virtual
Authors: Djikic‐Stojsic Teodora , Bret Guillaume , Blond Gaëlle , Girard Nicolas , Le Guen Clothilde , Marsol Claire , Schmitt Martine , Schneider Séverine , Bihel Frederic , Bonnet Dominique , Gulea Mihaela , Kellenberger Esther 
Published: June 2024

AbstractA chemical library is a key element in the early stages of pharmaceutical research. Its design encompasses various factors, such as diversity, size, ease of synthesis, aimed at increasing the likelihood of success in drug discovery. This article explores the collaborative efforts of computational and synthetic chemists in tailoring chemical libraries for cost‐effective and resource‐efficient use, particularly in the context of academic research projects. It proposes chemoinformatics methodologies that address two pivotal questions: first, crafting a diverse panel of under 1000 compounds from an existing pool through synthetic efforts, leveraging the expertise of organic chemists; and second, expanding pharmacophoric diversity within this panel by creating a highly accessible virtual chemical library. Chemoinformatics tools were developed to analyse initial panel of about 10,000 compounds into two tailored libraries: eIMS and vIMS. The eIMS Library comprises 578 diverse in‐stock compounds ready for screening. Its virtual counterpart, vIMS, features novel compounds guided by chemists, ensuring synthetic accessibility. vIMS offers a broader array of binding motifs and improved drug‐like characteristics achieved through the addition of diverse functional groups to eIMS scaffolds followed by filtering of reactive or unusual structures. The uniqueness of vIMS is emphasized through a comparison with commercial suppliers′ virtual chemical space.
Resilience and distress among adolescents and young adults receiving hematopoietic cell transplantation: The Promoting Resilience in Stress Management randomized trial
Authors: Rosenberg Abby R. , Taylor Mallory R. , Fladeboe Kaitlyn M. , Zhou Chuan , Levine Deena R. , Johnston Emily E. , Freyer David R. , Comiskey Liam , Junkins Courtney C. , Bradford Miranda , Odom J. Nicholas , Baker K. Scott , Yi‐Frazier Joyce P. 
Published: June 2024

AbstractBackgroundAdolescents and young adults (AYAs) receiving hematopoietic cell transplantation (HCT) are at high risk of poor psychosocial health. This study aimed to determine whether the Promoting Resilience in Stress Management (PRISM) intervention mitigated these risks during the first 6 months posttransplant.MethodsThis multisite, parallel, randomized trial was conducted from April 2019 to March 2023. Eligible AYAs were aged 12–24 years, English speaking, and within 1 month of HCT for cancer or cancer predisposition syndrome. They were assigned 1:1 to PRISM (a brief, skills‐based intervention targeting “resilience resources” [stress management, goal setting, cognitive reframing, and meaning making]) or usual care (UC). Outcomes included total symptoms of depression and anxiety (Hospital Anxiety and Depression Scale; primary outcome), hope (Snyder Hope Scale), resilience (10‐item Connor–Davidson Resilience Scale), and health‐related quality of life (HRQOL; Pediatric Quality of Life Inventory Cancer Module). Analyses leveraged multivariable linear regressions; exploratory analyses assessed the influence of baseline depression or anxiety.ResultsOf 94 enrolled and randomized AYAs, the mean age was 16.7 years (SD, 4.2); 43 (46%) were female, 56 (60%) were non‐Hispanic White, 22 (23%) were Hispanic, and nine (10%) were Black. Most (77%) had leukemia. Of n = 50 randomized to PRISM and n = 44 to UC, 37 (74%) and 33 (73%) completed all study procedures, respectively. In intention‐to‐treat analyses, PRISM did not affect 6‐month depression and anxiety (β = −1.1; 95% CI, −3.7 to 1.5), hope (β = 0.83; 95% CI, −3.3 to 4.9), resilience (β = −0.01; 95% CI, −3.0 to 3.0), or HRQOL (β = 1.5; 95% CI, −4.7 to 7.9). Among AYAs with preexisting anxiety or depression, PRISM recipients reported greater 6‐month improvements in hope (score change, +3.71; SD, 6.9) versus UC recipients (score change, −2.76; SD, 6.5) (p = .04).ConclusionsResilience coaching did not influence outcomes in this sample. Exploratory findings suggest it may be more effective when directed toward those with concurrent distress.
Convergent encryption enabled secure data deduplication algorithm for cloud environment
Authors: Ahmad Shahnawaz , Arif Mohd. , Ahmad Javed , Nazim Mohd. , Mehfuz Shabana 
Published: June 2024

SummaryThe exponential growth of data poses a critical challenge for cloud storage systems. Redundant data consumes valuable storage space and increases infrastructure costs. Data deduplication, a technique for eliminating duplicate data copies, offers a promising solution. However, existing deduplication techniques often compromise data security, especially when dealing with encrypted data. This paper proposes a novel approach that merges convergent encryption (CE) with data deduplication. CE leverages user data itself to generate unique encryption keys, enabling secure deduplication on encrypted data. We analyze existing literature on secure data deduplication and categorize various techniques using UML activity diagrams. We then present our proposed CE‐based deduplication system, outlining its functionalities through UML diagrams. This research contributes to the field of secure data storage by proposing a novel and secure deduplication approach. By demonstrating its efficiency and security benefits, this work paves the way for more efficient and secure cloud storage solutions. Finally, we demonstrate the system's effectiveness through a comparative analysis, highlighting its potential to significantly improve storage efficiency while maintaining data security.
Organic Ferroelastic with Dual‐Channel Manipulation Obtained by H/F Substitution
Authors: Xu Yu‐Qiu , Lan Jin‐Fei , Mao Wei‐Xin , Zhou Long‐Xing , Deng Xin , Chen Xiao‐Gang , Zhang Han‐Yue 
Published: June 2024

AbstractFerroelastic materials with high phase transition temperature have broad application prospects in information conversion and storage, shape memory, energy conversion, hyperelasticity, etc. However, most of the current reports focus on inorganic ferroelastic materials. Inorganic ferroelastic materials have the disadvantages of high energy consumption and harmful metals, which limit their application in practical work. In contrast, organic ferroelastic materials have the advantages of structural adjustability, environmental protection, easy processing, low cost, mechanical flexibility, and so on, which have great development potential in new ferroelastic materials. Here, we have successfully designed and synthesized a pair of homochiral enantiomers [(R/S)‐4‐fluorobenzoic acid‐2‐amino‐2‐phenylethanol] (R‐ and S‐F) using the chemical design strategy of H/F substitution. Compared with the non‐F substitution [(R/S)‐benzoic acid‐2‐amino‐2‐phenylethanol] (R‐ and S‐H), they undergo 2F1‐type ferroelastic phase transitions at 370 K. Notably, the ferroelastic domains of R/S‐F can be controlled through two physical channels that are temperature and stress, showing great potential in dual‐channel switches.
Updated techniques and evidence for endoscopic ultrasound‐guided tissue acquisition from solid pancreatic lesions
Authors: Itonaga Masahiro , Ashida Reiko , Kitano Masayuki 
Published: June 2024

AbstractEndoscopic ultrasound‐guided tissue acquisition (EUS‐TA), including fine‐needle aspiration (EUS‐FNA) and fine‐needle biopsy (EUS‐FNB), has revolutionized specimen collection from intra‐abdominal organs, especially the pancreas. Advances in personalized medicine and more precise treatment have increased demands to collect specimens with higher cell counts, while preserving tissue structure, leading to the development of EUS‐FNB needles. EUS‐FNB has generally replaced EUS‐FNA as the procedure of choice for EUS‐TA of pancreatic cancer. Various techniques have been tested for their ability to enhance the diagnostic performance of EUS‐TA, including multiple methods of sampling at the time of puncture, on‐site specimen evaluation, and specimen processing. In addition, advances in next‐generation sequencing have made comprehensive genomic profiling of EUS‐TA samples feasible in routine clinical practice. The present review describes updates in EUS‐TA sampling techniques of pancreatic lesions, as well as methods for their evaluation.
Emerging Rare Earth Element Separation Technologies
Authors: Pramanik Subhamay , Kaur Sandeep , Popovs Ilja , Ivanov Alexander S. , Jansone‐Popova Santa 
Published: June 2024

AbstractRare earth elements are essential for numerous clean energy applications, yet their mining, separation, and processing pose significant environmental challenges. Traditional separation processes often result in ecological damage, highlighting the critical need for innovative techniques that reduce environmental impacts. This article reviews recent advancements in rare earth separation technologies, with a particular focus on the role of neutral organic compounds. It explores how these compounds change selectivity across the rare earth series, offering promising strategies for designing more effective rare earth element separation systems. Furthermore, the article points out research areas requiring additional investigation to improve the sustainability of these critical processes.
Controlled Reactivity of Viologens in Alkaline Solutions Via Cucurbit[7]uril Complexation
Authors: Bossavit Axel , Monnier Valérie , Siri Didier , Canard Gabriel , Gigmes Didier , Bardelang David , Kermagoret Anthony 
Published: June 2024

AbstractA series of N‐alkyl‐ and N‐aryl‐viologens has been studied in alkaline solutions. In this work, we evaluated the deuteration rate of the viologens in D2O solutions of pH values ranging from 7.3 to 12.7. Kinetic experiments and computational calculations showed the high reactivity of H−C(2) bonds toward deprotonation of N‐aryl‐pyridinium moieties compared to N‐alkyl‐pyridinium moieties, even in hybrid N‐aryl/N‐alkyl dissymmetric viologens. However this high H−C(2) reactivity in liquid phase contrasted with the proton fragmentation mechanism observed in the gas phase by mass spectrometry. The H/D exchange rate of viologens in very strong alkaline conditions could be significantly reduced using cucurbit[7]uril (CB[7]) as supramolecular protecting group. Ultimately, CB[7] inclusion led to a selective protection of H−C(2) group of N‐aryl‐pyridinium of dissymmetric viologens, and induced a supramolecular regioselective deuteration.
Effect of Juniperus communis extract on probiotic properties of Bacillus safensis isolated from camel milk in the region of El Oued (Algeria)
Authors: Layadi Ikram , Laiche Ammar Touhami , Tlili Mohammed Laid , Messaoudi Mohammed , Ghemam Amara Djilani , Mezghani‐Khemakhem Maha , Naccache Chahnez , Sawicka Barbara , Atanassova Maria , Zahnit Wafa , Ahmad Sheikh F. 
Published: June 2024

AbstractThe current study focuses on the effect of Juniperus communis extract on the probiotic properties of lactic acid bacteria isolated from camel milk in the region of El Oued (Algeria). Chromatographic analysis by HPLC was carried out to detect the most important compounds extracted from the plant. The total phenolic and flavonoid contents were determined using the colorimetric procedures Folin–Ciocalteu and aluminum chloride. The probiotic properties were studied and evaluated in vivo with Juniperus communis extracts after isolating strains from camel's milk and identifying them using 16S rRNA gene sequencing. Chromatographic profiles of the phenolic compounds revealed that Juniperus communis extract is rich in quercetin. After conducting chemical analyses of polyphenols and flavonoids, the results demonstrated a high content of phenolic compounds in Juniperus communis extracts (polyphenols: 103.80 ± 0.30 mg GAE/g E. flavonoids: 15.85 ± 0.80 mg QE/g E). Sequencing and phylogenetic analysis showed that the isolates belong to Bacillus pumilus and Bacillus safensis strains. The combination of Juniperus communis and Bacillus safensis restored the healthy intestine wall structure and returned the blood biochemical parameters to normal values. It was found that the mixture enhanced anti‐inflammatory effectiveness by reducing erythrocyte sedimentation rate and C‐reactive protein values. Juniperus communis has a high polyphenol and flavonoid content which can have a considerable impact on Bacillus safensis probiotic properties.