bluuebunny/crossref_metadata_2025_split huggingface dataset:
Selective Transcriptional Down-Regulation of Human Rhinovirus-Induced Production of CXCL10 from Airway Epithelial Cells via the MEK1 Pathway
Authors: Zaheer Raza S. , Koetzler Rommy , Holden Neil S. , Wiehler Shahina , Proud David 
Published: April 2009

Abstract
Human rhinovirus (HRV) infections can trigger exacerbations of lower airway diseases. Infection of airway epithelial cells induces production of a number of proinflammatory chemokines that may exacerbate airway inflammation, including CXCL10, a chemoattractant for type 1 lymphocytes and NK cells. Primary human bronchial epithelial cells and the BEAS-2B human bronchial epithelial cell line were used to examine the role of MAPK pathways in HRV-16-induced production of CXCL10. Surprisingly, PD98059 and U0126, two inhibitors of the MEK1/2-ERK MAPK pathway, significantly enhanced HRV-16-induced CXCL10 mRNA and protein. This enhancement was not seen with IFN-β-induced production of CXCL10. Studies using small interfering RNA revealed that knockdown of MEK1, but not MEK2, was associated with enhanced HRV-induced CXCL10 production. Promoter construct studies revealed that PD98059 and U0126 enhanced HRV-16-induced transcriptional activation of CXCL10. HRV-16-induced promoter activation was regulated by two NF-κB binding sites, κB1 and κB2, and by an IFN-stimulated response element. Inhibitors of the MEK1/2-ERK pathway did not alter HRV-16-induced activation of tandem repeat κB1 or κB2 constructs, nor did they alter HRV-16-induced nuclear translocation/binding of NF-κB to either κB1 or κB2 recognition sequences. Furthermore, PD98059 and U0126 did not alter phosphorylation or degradation of IκBα. In contrast, inhibitors of the MEK1/2-ERK pathway, and small interfering RNA knockdown of MEK1, enhanced nuclear translocation/binding of IFN regulatory factor (IRF)-1 to the IFN-stimulated response element recognition sequence in HRV-16 infected cells. We conclude that activation of MEK1 selectively down-regulates HRV-16-induced expression of CXCL10 via modulation of IRF-1 interactions with the gene promoter in human airway epithelial cells.
Inducible MHC Class II Expression by Mast Cells Supports Effector and Regulatory T Cell Activation
Authors: Kambayashi Taku , Allenspach Eric J. , Chang John T. , Zou Tao , Shoag Jonathan E. , Reiner Steven L. , Caton Andrew J. , Koretzky Gary A. 
Published: April 2009

Abstract
In addition to their well-established role as regulators of allergic response, recent evidence supports a role for mast cells in influencing the outcome of physiologic and pathologic T cell responses. One mechanism by which mast cells (MCs) influence T cell function is indirectly through secretion of various cytokines. It remains unclear, however, whether MCs can directly activate T cells through Ag presentation, as the expression of MHC class II by MCs has been controversial. In this report, we demonstrate that in vitro stimulation of mouse MCs with LPS and IFN-γ induces the expression of MHC class II and costimulatory molecules. Although freshly isolated peritoneal MCs do not express MHC class II, an in vivo inflammatory stimulus increases the number of MHC class II-positive MCs in situ. Expression of MHC class II granted MCs the ability to process and present Ags directly to T cells with preferential expansion of Ag-specific regulatory T cells over naive T cells. These data support the notion that, in the appropriate setting, MCs may regulate T cell responses through the direct presentation of Ag.
Selective Requirement for c-Myc at an Early Stage of Vα14i NKT Cell Development
Authors: Mycko Marcin P. , Ferrero Isabel , Wilson Anne , Jiang Wei , Bianchi Teresa , Trumpp Andreas , MacDonald H. Robson 
Published: April 2009

Abstract
Vα14 invariant (Vα14i) NKT cells are a subset of regulatory T cells that utilize a semi-invariant TCR to recognize glycolipids associated with monomorphic CD1d molecules. During development in the thymus, CD4+CD8+ Vα14i NKT precursors recognizing endogenous CD1d-associated glycolipids on other CD4+CD8+ thymocytes are selected to undergo a maturation program involving sequential expression of CD44 and NK-related markers such as NK1.1. The molecular requirements for Vα14i NKT cell maturation, particularly at early developmental stages, remain poorly understood. In this study, we show that CD4-Cre-mediated T cell-specific inactivation of c-Myc, a broadly expressed transcription factor with a wide range of biological activities, selectively impairs Vα14i NKT cell development without perturbing the development of conventional T cells. In the absence of c-Myc, Vα14i NKT cell precursors are blocked at an immature CD44lowNK1.1− stage in a cell autonomous fashion. Residual c-Myc-deficient immature Vα14i NKT cells appear to proliferate normally, cannot be rescued by transgenic expression of BCL-2, and exhibit characteristic features of immature Vα14i NKT cells such as high levels of preformed IL-4 mRNA and the transcription factor promyelocytic leukemia zinc finger. Collectively our data identify c-Myc as a critical transcription factor that selectively acts early in Vα14i NKT cell development to promote progression beyond the CD44lowNK1.1− precursor stage.
Group V Secretory Phospholipase A2 Modulates Phagosome Maturation and Regulates the Innate Immune Response against Candida albicans
Authors: Balestrieri Barbara , Maekawa Akiko , Xing Wei , Gelb Michael H. , Katz Howard R. , Arm Jonathan P. 
Published: April 2009

Abstract
Phospholipase A2 (PLA2) hydrolyzes the sn-2 position of cell membrane phospholipids to release fatty acids and lysophospholipids. We have previously reported that group V secretory PLA2 (sPLA2) translocates from the Golgi and recycling endosomes of mouse peritoneal macrophages to newly formed phagosomes and regulates the phagocytosis of zymosan, suggesting a role in innate immunity. Here we report that in macrophages lacking group V sPLA2, phagosome maturation was reduced 50–60% at early time points while the binding of zymosan was unimpaired. The ability of group V sPLA2 to regulate phagocytosis extended to phagocytosis of IgG- and complement-opsonized sheep RBC. Moreover, macrophages lacking group V sPLA2 had delays in phagocytosis, phagosome maturation, and killing of Candida albicans. Cytokine production and eicosanoid generation were not impaired by the lack of group V sPLA2. Furthermore, in a model of systemic candidiasis, mice lacking group V sPLA2 had an increased fungal burden in the kidney, liver, and spleen at day 7 postinfection and increased mortality. Thus, group V sPLA2 regulates phagocytosis through major phagocytic receptors and contributes to the innate immune response against C. albicans by regulating phagocytosis and killing through a mechanism that is likely dependent on phagolysosome fusion.
Adaptive Immune Response in JAM-C-Deficient Mice: Normal Initiation but Reduced IgG Memory
Authors: Zimmerli Claudia , Lee Boris P. L. , Palmer Gaby , Gabay Cem , Adams Ralf , Aurrand-Lions Michel , Imhof Beat A. 
Published: April 2009

Abstract
We have recently shown that junctional adhesion molecule (JAM)-C-deficient mice have leukocytic pulmonary infiltrates, disturbed neutrophil homeostasis, and increased postnatal mortality. This phenotype was partially rescued when mice were housed in ventilated isolators, suggesting an inability to cope with opportunistic infections. In the present study, we further examined the adaptive immune responses in JAM-C−/− mice. We found that murine conventional dendritic cells express in addition to Mac-1 and CD11c also JAM-B as ligand for JAM-C. By in vitro adhesion assay, we show that murine DCs can interact with recombinant JAM-C via Mac-1. However, this interaction does not seem to be necessary for dendritic cell migration and function in vivo, even though JAM-C is highly expressed by lymphatic sinuses of lymph nodes. Nevertheless, upon immunization and boosting with a protein Ag, JAM-C-deficient mice showed decreased persistence of specific circulating Abs although the initial response was normal. Such a phenotype has also been observed in a model of Ag-induced arthritis, showing that specific IgG2a Ab titers are reduced in the serum of JAM-C−/− compared with wild-type mice. Taken together, these data suggest that JAM-C deficiency affects the adaptive humoral immune response against pathogens, in addition to the innate immune system.
Enhancement of the surface and bulk mechanical properties of polystyrene through the incorporation of raw multiwalled nanotubes with the twin‐screw mixing technique
Authors: Liu Sung‐Po , Hsu Wei‐Lun , Chang Kung‐Chin , Yeh Jui‐Ming 
Published: April 2009

AbstractIn this article, we present the effects of incorporated multiwalled nanotubes (MWNTs) on a metal surface and the bulk mechanical properties of as‐synthesized polystyrene (PS)–MWNT composites prepared with the twin‐screw mixing technique. The MWNTs used for preparing the composites were raw compounds that were not treated with any surface modifications. The morphology for the dispersion capability of the MWNTs in the PS matrix was subsequently characterized with transmission electron microscopy. Surface mechanical property studies (i.e., wear resistance and hardness) showed that the integration of MWNTs led to a distinct increase in the wear resistance and also the micro/nanohardness with up to a 5 wt % MWNT loading in the composites. Moreover, the enhancement of the wear resistance of the as‐prepared composites, in comparison with pure PS, was further identified with scanning electron microscopy observations of the surface morphology after testing. On the other hand, for bulk mechanical property studies (i.e., the tensile strength and flexural strength), the composites containing a 3 wt % concentration of MWNTs in the PS matrix exhibited the best performance with respect to the tensile strength and flexural strength. This means that this composition of MWNTs exhibited good compatibility with the PS matrix, and this can be attributed to the π–π interacting forces existing between the aromaticity of the MWNTs and PS matrix. Furthermore, at higher MWNT loadings (e.g., 5 wt %), raw MWNTs were aggregated in the polymer matrix, as observed by transmission electron microscopy. Also, this led to an obvious decrease in the tensile strength and flexural strength. © 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2009
Methylolation of melamine with incipient condensation. II. Mathematical modeling
Authors: Nicolau V. V. , Estenoz D. A. , Meira G. R. 
Published: April 2009

AbstractA novel mathematical model is presented for the reaction between melamine (M) and formaldehyde (F) at pH = 9.0 and at temperatures between 38 and 90°C. It is based on a kinetic scheme that includes reversible methylolations, irreversible formation of (unsubstituted) methylene bridges, reversible formation of (unsubstituted) ether bridges, instantaneous dissolution of M, and instantaneous equilibrium for the hydration/dehydration of F. The model predicts the distributions of molecular weights and functionalities of the evolving MF resin. Arrhenius expressions were adjusted for the seven kinetic constants on the basis of measurements reported in the first part of this series. Even though the final products contain thousands of different molecular species, 21 of them constitute more than 90% of the total weights. During the initial period with negligible condensation, the undissolved M distorts the distributions of molecular weights and functionalities; but the reversibility of methylolations corrects for such distortion prior to the effective start of condensation. © 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2009
Ionic liquid‐H2O Resulting in a Highly Chemoselective Oxidation of Benzylic Alcohols in the Presence of Aliphatic Analogues Catalyzed by Immobilized TEMPO
Authors: HU Ruijun , LEI Ming , WEI Hegeng , WANG Yanguang 
Published: April 2009

AbstractIn ionic liquid 1‐butyl‐3‐methylimidazolium hexafluorophosphate ([bmim][PF6])‐H2O, a highly chemoselective oxidation of benzylic alcohols in the presence of aliphatic ones to the corresponding hydroxyl benzyl aldehydes and ketones was allowed in high yields using N‐chlorosuccinimide (NCS)/NaBr/IL‐TEMPO (ionic liquid immobilized 2,2,6,6‐tetramethylpiperidine‐1‐oxyl) as a facile and effective catalytic oxidation system. The medium, [bmim][PF6], together with the catalyst IL‐TEMPO could be easily recycled for ten runs without any influence on the efficacy of the reaction in terms of yield and selectivity of the product.
Titanium dioxide nanotubes enhance bone bonding in vivo
Authors: Bjursten Lars M. , Rasmusson Lars , Oh Seunghan , Smith Garrett C. , Brammer Karla S. , Jin Sungho 
Published: April 2009

AbstractImplant topography is critical to the clinical success of bone‐anchored implants, yet little is known how nano‐modified implant topography affects osseointegration. We investigate the in vivo bone bonding of two titanium implant surfaces: titanium dioxide (TiO2) nanotubes and TiO2 gritblasted surfaces. In previous in vitro studies, the topography of the TiO2 nanotubes improved osteoblast proliferation and adhesion compared with gritblasted titanium surfaces. After four weeks of implantation in rabbit tibias, pull‐out testing indicated that TiO2 nanotubes significantly improved bone bonding strength by as much as nine‐fold compared with TiO2 gritblasted surfaces. Histological analysis confirmed greater bone‐implant contact area, new bone formation, and calcium and phosphorus levels on the nanotube surfaces. It is anticipated that further studies will contribute to a better understanding of the effect of implant nanotopography on in vivo bone formation and bonding strength. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res, 2010
Picryl derivatives of benzo[1,2‐d:4,5‐d′]bistriazole and benzo[1,2‐d:4,5‐d′]bistriazole‐4,8‐dione
Authors: Berlin Jane K. , Coburn Michael D. 
Published: April 2009

AbstractIn a previous communication from this laboratory it was reported that benzotriazole reacts with both picryl chloride and picryl fluoride to give 1‐picrylbenzotriazole exclusive of any 2‐picrylbenzotriazole (3). As an extension of this study we have examined the reactions of benzo[1,2‐d:4,5‐d′]bistriazole (I) and benzo[1,2‐d:4,5‐d′]bistriazole‐4,8‐dione (II) with picryl fluoride.
Aminoacid and protein conjugates with biologically active purines
Authors: Vidal‐Gomez J. , Greenbaum J. H. , Giner‐Sorolla A. 
Published: April 2009

AbstractCondensation products of amino acids and proteins with biologically active purines have been obtained to study their potential tumor inhibitory activity and as models for the preparation of conjugates with tumor specific antibodies. Among the new compounds are 2‐glycinyl‐6‐methylmercaptopurine (5), 2‐glycinyl‐6‐mercaptopurine (6), 2‐glycinyl‐6‐chloropurine (16), 2‐glycinyl‐6‐hydroxylaminopurine (18), 2‐glycinylpurine (8) and 2‐glycinyl‐6‐methylpurine (7). 9‐Alkylpurines led to new purine derivatives, such as 6‐chloro‐9H‐purine‐9‐acetic acid (22) and 6‐hydroxylamino‐9H‐purine‐9‐acetylhydroxamic acid (23). These derivatives were coupled to bovine serum albumin (BSA) to yield conjugates. The amino acid‐purines 6‐cysteinyl (27) and 6‐glutathionyl‐S‐purine 3‐oxide (28) were obtained from 6‐chloropurine 3‐oxide (26). Other protein‐purine 3‐oxide conjugates were obtained with 6‐mercaptopurine 3‐oxide (29) and 6‐bromomethylpurine 3‐oxide (33).
The reduction of l‐methyl‐3‐methoxy‐5‐arylpyrrole‐2‐ and ‐4‐carboxylic esters with selected reducing agents
Authors: Campaigne E. , Shutske G. M. 
Published: April 2009

AbstractThree new rnethoxypyrrole esters, ethyl 1‐methyl‐3‐methoxy‐5‐phenylpyrrole‐2‐earboxylate, diethyl l‐methyl‐3‐methoxy‐5‐phenylpyrrole‐2,4‐diearboxylate, and ethyl l‐methyl‐2‐phenyl‐4‐methoxypyrrole‐3‐carboxylate were reduced with diborane/tetrahydrofuran, lithium aluminum hydride, and some related reducing agents. In each case diborane reduced the ethoxycarbonyl group to a methyl group and lithium aluminum hydride reduced it to a hydroxymethyl group.
Solvent effects in the reaction of 2‐thiophenesulfonyl chloride with aniline
Authors: Arcoria Antonino , Maccarone Emanuele , Tomaselli Gaetano A. , Calí Rosario , Currieri Salvatore 
Published: April 2009

AbstractThe second order rate constants k2 and the activation parameters for the reaction of 2‐thiophenesulfonyl chloride with aniline together with solution enthalpies of the reactants have been measured in methanol, ethanol, 2‐propanol, acetonitrile and acetone. The reaction rates are slower in dipolar aprotic solvents than in protic ones due to a remarkable activation negative entropy. The rate constants k2 are correlated with empirical solvent polarity parameters. The data seem in accord with a SAN reaction mechanism.
The synthesis and some chemical and spectroscopic properties of imidazo [1,2‐a] pyrazine
Authors: Depompei Michael F. , Paudler William W. 
Published: April 2009

AbstractThe parent imidazo [1,2‐a] pyrazine was prepared and shown to undergo electrophilic bromination at C‐3, and base‐catalyzed H→D exchange at C‐3 and C‐5. The perchloro derivative of this ring system was prepared and it was established that nucleophilic substitution by methoxide ion occurs at C‐5 and C‐8. Pmr spectral data for all compounds are presented.
Studies on isoindoline derivatives and related compounds. I Synthesis and reduction of 1,3‐dicarboethoxymethyleneisoindoline
Authors: Kurihara Takushi , Fukunaga Keizo , Sakaguchi Toshiko , Hirano Hiroshi 
Published: April 2009

AbstractThe reaction of iminoether III with benzyl cyanoacetate gave ethyl 1‐(α‐cyanocarbobenzyl‐oxymethylene)isoindoline‐3‐acetate (V) in a 26% yield. Decarboxylation of ethyl 1‐(α‐cyanocarboxymethylene)isoindoline‐3‐acetate (VI), obtained by hydrogenolysis of V, gave a mixture of 1‐carboethoxymethyleneisoindoline‐3‐acetonitrile (VII) as major component and 1‐carboethoxymethylene‐3‐cyanomethyleneisoindoline (VIII) as minor component, which were reconvertible into each other. On the other hand, decarboxylation of VI was successfully carried out to give VII as a single product under a nitrogen atmosphere. Ethanolysis and autoxidation of VII gave crystalline diethyl 1,3‐dicarboethoxymethyleneisoindoline (XIII). Catalytic hydrogenation of of XIII over platinum oxide gave diethyl isoindoline‐cis‐1,3‐diacetate (XIV) in a yield of 92%. The uv spectra of these 1,3‐disubstituted isoindoline derivatives are summarized in Table I.
Chiral 1,4‐benzodiazepines. IX. Attempts at a preparation of 7‐chloro‐5‐phenyl‐3(S)methyl‐1,4‐benzodiazepin‐2‐one through C(5)C(5a) bond formation
Authors: Šunjić V. , Kajfež F. , Blažević N. , Oklobdžija M. , Mildner P. 
Published: April 2009

AbstractDuring attempts at preparation of 7‐chloro‐5‐phenyl‐3(S)methyl‐1,4‐benzodiazepin‐2‐one (9) by cyclisation of N'‐α‐chlorobenzylidene‐(S)alanyl‐p‐chloroaniline (7) and the related o,p‐dichloroaniline derivative (8), it was observed that the intermediate products, both N'‐benzylidene‐(S)alanyl‐p‐chloroaniline (5), as well as the related o,p‐dichloroaniline derivative (6), undergo cyclisation to N‐(p‐chlorophenyl)‐2‐phenyl‐4(S)methylimidazolidin‐5‐one (17), and N‐(o,p‐dichlorophenyl)imidazolidin‐5‐one (18), respectively. Isolation and properties of the side products, N'‐benzylated‐(S)alanyl‐p‐chloro‐, and o,p‐dichloroanilines (15 and 16), as well as of N'‐benzoylated‐(S)alanyl‐p‐chloroanilines (19 and 20) are described.
Alkylation par des dérivés d'indole. N‐Ethylation de pipéridines par le méthyl‐1 ethoxy‐2 indole carboxylate‐3 d'éthyle
Authors: Deberly A. , Abenhaim D. , Bourdais J. 
Published: April 2009

AbstractLe méthyl‐1 éthoxy‐2 indole carboxylate‐3 d'éthyle se compurte comme un agent alcoylant vis à vis de nucléophiles comme la piperidine ou la méthyl‐2 piperidine. Cette réaction est très sensible aux effets stériques comme le montre les vitesses d'éthylation différentes de ces deux amines. On observe aussi – avec la pipéridine – une réaction d'amidification de la function ester mais le groupe éthoxy‐2 est attaqué préférentiellement.
The chemistry of 1,2,5‐thiadiazoles V. Synthesis of 3,4‐diamino‐1,2,5‐thiadiazole and [1,2,5] thiadiazolo[3,4‐b]pyrazines
Authors: Komin Andrew P. , Carmack Marvin 
Published: April 2009

AbstractThe o‐diamine, 3,4‐diamino‐1,2,5‐thiadiazole (2), was synthesized from 3,4‐dichloro‐1,2,5‐thiadiazole (3) hy three methods. Aqueous glyoxal cyclized 2 into [1,2,5]thiadiazolo[3,4–6]‐pyrazine (14). 3,4‐Dichloro‐1,2,5‐thiadiazole 1,1‐dioxide (18) reaeted with 2 to give 1,3‐dihydro‐bis[1,2,5]thiadiazolo[3,4‐b:3′,4′‐e]pyrazine 2,2‐dioxide (19). The reaction of 2 with selenium oxyehloride led to [1,2,5]selenadiazolo[3,4‐c] [1,2,5]thiadiazole (12). Ring closure of 2,3‐diaminoquinoxaline (4) with thionyl chloride or selenium oxychloride gave [1,2,5]thiadiazolo‐[3,4‐b]quinoxaline (21) and [1,2,5]selenadiazolo[3,4‐b]quinoxaline (22), respectively. Sulfurous acid reduced 21 to the 4,9‐dihydro derivative 23, which was reoxidized to 21 with chloranil. Aqueous hase hydrolyzed 21 to 4 via the hydrated intermediate 24. Aqueous glyoxal cyclized 4 to the covalent hydrate of pyrazino[2,3‐b]quinoxaline (26), 27, which was dehydrated to 26. Compound 26 underwent rapid addition of two alcohols in a process analogous to covalent hydration.
Studies on the syntheses of heterocyclic compounds. Part DCXLIV . Catalytic reduction of homoproaporphine related compounds
Authors: Kametani Tetsuji , Fukumoto Keiichiro , Satoh Fumio , Kigasawa Kazuo , Sugi Hideo 
Published: April 2009

AbstractHydrogenation of the homoproaporphine (IV) over platinum oxide gave a mixture of the cyclohexanols VIIa and VIIb. In contrast, reduction of IV on palladium provided the cyclo‐hexanone VI, which was also obtained from VIIb by oxidation. Treatment of the cyclohexanols VIIa and VIIb under hydrogen on platinum oxide afforded the same mixture of VIIa and VIIb.
A propos de la structure de pyrimidines obtenues par condensation de l'acide cyanacétique et de monoalkylurées
Authors: Lefebvre Alain , Bernier Jean‐Luc , Lespagnol Ch. 
Published: April 2009

AbstractIl est classiquement admis que la condensation de l'acide cyanacétique et d'une monoalkylurée conduit à la formation d'une alkyl‐1 dioxo‐2,4 amino‐6 tétrahydro‐1,2,3,4 pyrimidine. Cependant, la vérification n'en a été réalisée que dans deux cas et par une synthèse longue et délicate. L'étude de la N′ cyanacétyl N isobutylurée, intermédiaire de la préparation d'une telle pyrimidine, apporte une confirmation supplémentaire s'appuyant sur une étude en RMN. La méthode utilisée est généralisable.
Synthesis of 3‐Chloro‐2‐hydroxyimipramine and 3‐chloro‐8‐hydroxyimipramine, Hypothetical metabolites of clomipramin
Authors: Zirnis Aija , Piszkiewicz Frederick F. , Martian Albert A. 
Published: April 2009

AbstractFremy salt oxidation of 3‐chloroiminodibenzyl yields a mixture of two isomeric iminequinones, which can be separated and reduced to aminophenols and the phenolic group protected with addition of dihydropyran. Introduction of theN,N‐dimethylaminopropyl side chain and removal of the protective group provided the two chlorohydroxyimipramines, which can serve as standards for the identification of possible biotransformation products of the parent drug, clomipramine.
Syntheses de naphthyridines‐1,7
Authors: Decormeille M. M. A. , Guignant F. , Queguiner G. , Pastour P. 
Published: April 2009

AbstractLa condensation de l'amino‐3 isonicotinaldéhyde avec des composés à méthyle ou méthylene activé par un groupement carbonyle conduit à des alkyl naphthyridines‐1,7 et à des systèmes polyhétérocycliques à noyaux assemblés.
Recherches sur les hétérostéroïdes. V. Synthèse et configuration des éthers méthyliques de la benzo‐15,16‐ et de la cyclohexano‐15,16‐méthoxy‐2 diaza‐8,13 oestrone
Authors: Redeuilh GÉRard , Viel Claude , Leroy FranÇOise , Hospital Michel 
Published: April 2009

AbstractSynthèses stéréospécifiques des hétérostéroïdes mentionnés ci‐dessus, par cyclisation réductrice de la diméthoxy‐6,7 phtalimidoéthyl‐1 dihydro‐3,4 isoquinoléine. Détermination de leur configuration par spectroscopie IR et de RMN, et par radiocristallographie.