bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microglial activation mediates de novo lysophosphatidic acid production in a model of neuropathic pain
Authors: Ma Lin , Nagai Jun , Ueda Hiroshi 
Published: August 2010

J. Neurochem. (2010) 115, 643–653.AbstractWe recently demonstrated that de novo lysophosphatidic acid (LPA) production in the spinal cord occurs in the early phase after nerve injury or LPA injection, and underlies the peripheral mechanisms of neuropathic pain. In this study, we examined the possible involvement of spinal cord microglia in such LPA‐mediated functions. Intrathecal LPA injection rapidly increased the gene expression of CD11b and protein expression of phosphor‐p38, accompanied by a morphological change of microglia from a ramified to amoeboid shape. Although early treatment with minocycline significantly inhibited LPA‐induced neuropathic pain‐like behavior and microglial activation, late treatment did not. Early treatment with minocycline also blocked LPA‐evoked de novo LPA production and the increased activation of cytosolic phospholipase A2, an LPA synthesis‐related enzyme. Similar results were observed when the sciatic nerve was partially injured: early, but not late, treatment with minocycline significantly inhibited the injury‐induced neuropathic pain, microglial activation, de novo LPA production and the underlying increased activation of cytosolic phospholipase A2 as well as calcium‐independent phospholipase A2, another LPA synthesis‐related enzyme. These findings suggest that the early phase of microglial activation is involved in de novo LPA production, and that this underlies the initial mechanisms of nerve injury‐induced neuropathic pain.
Evidence for multiple burial–partial exhumation cycles from the Onodani eclogites in the Sambagawa metamorphic belt, central Shikoku, Japan
Authors: KABIR M. F. , TAKASU A. 
Published: August 2010

AbstractEclogites from the Onodani area in the Sambagawa metamorphic belt of central Shikoku occur as layers or lenticular bodies within basic schists. These eclogites experienced three different metamorphic episodes during multiple burial and exhumation cycles. The early prograde stage of the first metamorphic event is recorded by relict eclogite facies inclusions within garnet cores (XSps 0.80–0.24, XAlm 0–0.47). These inclusions consist of relatively almandine‐rich garnet (XSps 0.13–0.24, XAlm 0.36–0.45), aegirine‐augite/omphacite (XJd 0.08–0.28), epidote, amphiboles (e.g. actinolite, winchite, barroisite and taramite), albite, phengite, chlorite, calcite, titanite, hematite and quartz. The garnet cores also contain polyphase inclusions consisting of almandine‐rich garnet, omphacite (XJd 0.27–0.28), amphiboles (e.g. actinolite, winchite, barroisite, taramite and katophorite) and phengite. The peak P–T conditions of the first eclogite facies metamorphism are estimated to be 530–590 °C and 19–21 kbar succeeded by retrogression into greenschist facies. The second prograde metamorphism began at greenschist facies conditions. The peak metamorphic conditions are defined by schistosity‐forming omphacites (XJd ≤ 49) and garnet rims containing inclusions of barroisitic amphibole, phengite, rutile and quartz. The estimated peak metamorphic conditions are 630–680 °C and 20–22 kbar followed by a clockwise retrograde P–T path with nearly isothermal decompression to 8–12 kbar. In veins cross‐cutting the eclogite schistosity, resorbed barroisite/Mg‐katophorite occurs as inclusions in glaucophane which is zoned to barroisite, suggesting a prograde metamorphism of the third metamorphic event. The peak P–T conditions of this metamorphic event are estimated to be 540–600 °C and 6.5–8 kbar. These metamorphic conditions are correlated with those of the surrounding non‐eclogitic Sambagawa schists. The Onodani eclogites were formed by subduction of an oceanic plate, and metamorphism occurred beneath an accretionary prism. These high‐P/T type metamorphic events took place in a very short time span between 100 and 90 Ma. Plate reconstructions indicate highly oblique subduction of the Izanagi plate beneath the Eurasian continent at a high spreading rate. This probably resulted in multiple burial and exhumation movements of eclogite bodies, causing plural metamorphic events. The eclogite body was juxtaposed with non‐eclogitic Sambagawa schists at glaucophane stability field conditions. The amalgamated metamorphic sequence including the Onodani eclogites were exhumed to shallow crustal/surface levels in early Eocene times (c. 50 Ma).
What Effect Did AIG's Bailout, and the Preceding Events, Have on Its Competitors?
Authors: Egginton Jared F. , Hilliard James I. , Liebenberg Andre P. , Liebenberg Ivonne A. 
Published: August 2010

AbstractWe examine the effect of American International Group's (AIG) bailout, and the events leading up to it, on its insurance industry rivals. The reaction of rivals to AIG‐related events depends on the relative strength of two competing effects. The contagion effect implies that rival returns will decrease following negative events affecting AIG. In contrast, competitive effects will occur if investors expect that rivals will be able to benefit from AIG's downfall. Using three‐factor multivariate regression model event study methodology, we find evidence of both effects around several key dates in AIG's decline.
Depth of response assessed by quantitative ASO‐PCR predicts the outcome after stem cell transplantation in multiple myeloma
Authors: Putkonen Mervi , Kairisto Veli , Juvonen Vesa , Pelliniemi Tarja‐Terttu , Rauhala Auvo , Itälä‐Remes Maija , Remes Kari 
Published: August 2010

AbstractAchievement of complete response (CR) is a new goal of therapy for multiple myeloma (MM). By sensitive methods, the depth of response can be measured even among the patients in CR. We used a sensitive real‐time quantitative polymerase chain reaction by allele‐specific primers (qASO‐PCR) to assess the level of minimal residual disease (MRD) in bone marrow of 37 patients with myeloma who had achieved CR/near‐to‐CR after autologous or allogeneic stem cell transplantation (SCT). Allele‐specific primers could be successfully designed for 86% of patients. Three to six months after autotransplantation, the PCR target was not detectable in 53% of patients (16/30 patients), and the respective figure after allotransplantation was 71% (5/7 patients); the median sensitivity of PCR assay was <0.002%. The proportion of patients without detectable PCR target was 22% of all autotransplanted patients. A threshold level of 0.01% in the qASO‐PCR assay 3–6 months after SCT was found to be a useful cut‐off limit to divide the patients into two prognostic groups: MRD low/negative vs. MRD high. Low/negative MRD after SCT was a significant predictive factor for the prolongation of progression free (70 vs. 19 months; P = 0.003) and suggestively also for overall survival. We conclude that not only CR but also its depth is important for the long‐term outcome in MM.
Weighted performance index for objective evaluation of border detection methods in dermoscopy images
Authors: Garnavi Rahil , Aldeen Mohammad , Celebi M. E. 
Published: August 2010

Purpose: This paper presents a novel approach for objective evaluation of border detection in dermoscopy images of melanoma.Background: In melanoma studies, border detection is a fundamental step toward the development of a computer‐aided diagnosis system. Therefore, its accuracy is essential for accurate implementation of the subsequent parts of the diagnostic system.Method: An objective evaluation procedure of border detection methods is presented. The evaluation procedure uses the weighted performance index, which is composed of weighted metrics of sensitivity, specificity, accuracy, precision, border error and similarity. This index can also be used to optimize the parameters of a border detection method.Result and conclusion: Experiments are performed on 55 high‐resolution dermoscopy images. Using the union of four sets of dermatologist‐drawn borders as the ground truth, weighted metrics of sensitivity, specificity, accuracy, precision, border error and similarity are evaluated. Then, the weighted performance index is constructed and used to optimize the parameters of the hybrid border detection method. The outcome of the optimization process, verified through statistical analysis, yields a higher degree of agreement between automatic borders and the ground truth, compared with using standard metrics only. Finally, the weighted performance index is used to evaluate five recently reported border detection methods.
Differential roles of the pRb and Arf/p53 pathways in murine naevus and melanoma genesis
Authors: Ferguson Blake , Konrad Muller H. , Handoko Herlina Y. , Khosrotehrani Kiarash , Beermann Friedrich , Hacker Elke , Peter Soyer H. , Bosenberg Marcus , Walker Graeme J. 
Published: August 2010

SummaryWe report on a systematic analysis of genotype‐specific melanocyte (MC) UVR responses in transgenic mouse melanoma models along with tumour penetrance and comparative histopathology. pRb or p53 pathway mutations cooperated with NrasQ61K to transform MCs. We previously reported that MCs migrate from the follicular outer root sheath into the epidermis after neonatal UVR. Here, we found that Arf or p53 loss markedly diminished this response. Despite this, mice carrying these mutations developed melanoma with very early age of onset after neonatal UVR. Cdk4R24C did not affect the MC migration. Instead, independent of UVR exposure, interfollicular dermal MCs were more prevalent in Cdk4R24C mice. Subsequently, in adulthood, these mutants developed dermal MC proliferations reminiscent of superficial congenital naevi. Two types of melanoma were observed in this model. The location and growth pattern of the first was consistent with derivation from the naevi, while the second appeared to be of deep dermal origin. In animals carrying the Arf or p53 defects, no naevi were detected, with all tumours ostensibly skipping the benign precursor stage in progression.
Comparison of long-term financial implications for five veterinary career tracks
Authors: Gordon Meg E. , Lloyd James W. , Harris-Kober Donna L. 
Published: August 2010

Abstract
Objective—To compare present values of expected income streams for 5 distinct veterinary medical career tracks.
Design—Present value model.
Sample Population—AVMA survey data.
Procedures—Present values of expected income streams (net of debt repayment) were created and ranked. Sensitivity to each independent variable was assessed.
Results—Career present value at 34 years after graduation (CPV34) was highest for board-certified specialist (SP; $2,272,877), followed by practice owner (PO; $2,119,596), practice owner buying into practice after 10 years (PO-10; $1,736,333), SP working three-fouths time (SP3/4; $1,702,744), and general practitioner (GP; $1,221,131). Compared with CPV34 for SP, other career tracks yielded values of 93.3% (PO), 76.4% (PO-10), 74.9% (SP3/4), and 53.7% (GP). The model was robust to debt, interest rate, loan term, and discount rate but was sensitive to mean starting incomes and mean incomes.
Conclusions and Clinical Relevance—Greatest return on time and money invested by a veterinary student is through practicing full-time as an SP or through being a PO. Being an SP or SP3/4 was substantially more lucrative than being a GP and was comparable to being a PO. Practice ownership and working as an SP3/4 may be options for balancing financial gain with free time. Specialty training and practice ownership may be career tracks with the best potential repayment options for veterinarians with a large educational debt. Regardless of the amount of debt, the type of practice, mean incomes in a particular field, personal lifestyle, and professional interests are important factors when deciding among career tracks.
Central diabetes insipidus in an African Grey parrot
Authors: Starkey Simon R. , Wood Catherine , de Matos Ricardo , Ledbetter Eric C. , Morrisey James K. 
Published: August 2010

Abstract
Case Description—A 5.5-year-old sexually intact female African Grey parrot (Psittacus erithacus) was evaluated for a 1-year history of pronounced polyuria and polydipsia. The bird also had a 1-month history of signs of mild depression and mydriasis.
Clinical Findings—Physical examination revealed a thin body condition and incomplete bilateral mydriasis. Other examination findings as well as CBC and screening radiography results were unremarkable. Plasma biochemical analysis revealed mild hypernatremia. The bird had a 3.3% loss in body weight over 170 minutes during a water deprivation test, and urine osmolality remained low. After IM administration of 0.9 μg of desmopressin, the rate of weight loss decreased substantially and urine osmolality increased 300% over the following 200 minutes.
Treatment and Outcome—Initial attempts to treat the bird with orally administered desmopressin failed to correct the polydipsia and polyuria. Ultimately, IM administration of 24 μg of desmopressin/kg (10.9 μg/lb) every 12 hours yielded a noticeable reduction in water consumption and urine production over a 6- to 8-hour period. Eight months later, the bird was returned for a recheck examination, at which time it was in good health and continued to respond to the medication. Despite continued response to the medication, right-sided internal ophthalmoparesis was detected 16 months after the initial diagnosis.
Clinical Relevance—To the authors' knowledge, central diabetes insipidus in birds has not been reported. The condition should be considered in birds with clinical signs of disease similar to those in mammals. Long-term IM administration of desmopressin may be a viable treatment option.
Risk factors associated with cataracts and lens luxations in captive pinnipeds in the United States and the Bahamas
Authors: Colitz Carmen M. H. , Saville William J. A. , Renner Michael S. , McBain James F. , Reidarson Thomas H. , Schmitt Todd L. , Nolan Elizabeth C. , Dugan Steven J. , Knightly Felicia , Rodriguez Maya M. , Mejia-Fava Johanna C. , Osborn Steven D. , Clough Patricia L. , Collins Scott P. , Osborn Beverly A. , Terrell Kimberly 
Published: August 2010

Abstract
Objective—To determine risk factors for lens luxation and cataracts in captive pinnipeds in the United States and the Bahamas.
Design—Cross-sectional study.
Animals—111 pinnipeds (99 California sea lions [Zalophus californianus], 10 harbor seals [Phoca vitulina], and 2 walruses [Odobenus rosmarus]) from 9 facilities.
Procedures—Eyes of each pinniped were examined by a veterinary ophthalmologist for the presence of cataracts or lens luxations and photographed. Information detailing husbandry practices, history, and facilities was collected with a questionnaire, and descriptive statistical analyses were performed for continuous and categorical variables. Odds ratios and associated 95% confidence intervals were estimated from the final model.
Results—Risk factors for lens luxation, cataracts, or both included age ≥ 15 years, history of fighting, history of ocular disease, and insufficient access to shade.
Conclusions and Clinical Relevance—Diseases of the lens commonly affect captive pinnipeds. Access to UV-protective shade, early identification and medical management of ocular diseases, and prevention of fighting can limit the frequency or severity of lens-related disease in this population. An extended life span may result from captivity, but this also allows development of pathological changes associated with aging, including cataracts.
ChemInform Abstract: Molecular Complexes of Nitric Acid with N2, CO and NO Studied by Matrix Isolation IR Spectroscopy.
Authors: BARNES A. J. , LASSON E. , NIELSEN C. J. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Hexaamidostannates(IV) of the Alkali Metals Potassium, Rubidium and Caesium, M2(Sn(NH2)6) (M: K, Rb, Cs), Synthesis and Crystal Structures.
Authors: FLACKE F. , JACOBS H. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: New Iron(II) Complex Metal Hydrides with SrMg2FeH8 Type Structure.
Authors: HUANG B. , YVON K. , FISCHER P. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Structural Order in Complexes of the AIIBIIP2O7 Series: BaPbP2O7, PbCoP2O7, PbMnP2O7 and PbCuP2O7.
Authors: ELMARZOUKI A. , BOUKHARI A. , HOLT E. M. , BERRADA A. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Structure of Yb19Mg8H54, a New Salt‐Like Ternary Metal Hydride.
Authors: HUANG B. , GINGL F. , YVON K. , RODRIGUEZ‐CARVAJAL J. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: σ‐Dibarium Pyrophosphate.
Authors: ELBELGHITTI A. A. , ELMARZOUKI A. , BOUKHARI A. , HOLT E. M. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis, Crystal Structure Redetermination and Vibrational Spectra of β‐VOSO4.
Authors: BOGHOSIAN S. , ERIKSEN K. M. , FEHRMANN R. , NIELSEN K. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Crystal Structure of Cesium Fluorotrioxochromate(VI), CsCrO3F.
Authors: ROEGNER P. , RANGE K.‐J. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: K2NiWO2(PO4)2: A New Structure Type Related to KTiOPO4 (KTP).
Authors: PEUCHERT U. , BOHATY L. , FROEHLICH R. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Lead(II) Hydrogenselenite.
Authors: KOSKENLINNA M. , VALKONEN J. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Passivation of Electrodeposited Chromium Due to Electrochemical Pretreatment.
Authors: LALVANI S. B. , KANG J.‐C. , MURTHY M. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Transpassive Corrosion of Stainless Steel in Stabilized Alkaline Peroxide Solution.
Authors: LAYCOCK N. J. , NEWMAN R. C. , STEWART J. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Selective Catalytic Reduction of Nitric Oxide with Ammonia on MFI‐Type Ferrisilicate.
Authors: UDDIN MD. A. , KOMATSU T. , YASHIMA T. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Cubic and Hexagonal Faujasites with Varying Si/Al Ratios. Part 1. Synthesis and Characterization.
Authors: LOHSE U. , PITSCH I. , SCHREIER E. , PARLITZ B. , SCHNABEL K.‐H. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Structure of the Cluster Azides: A4(Nb6Cl12(N3)6)(H2O)2 with A: Rb, Cs.
Authors: RECKEWEG O. , MEYER H.‐J. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: New Niobium and Tantalum Chlorides of the Composition A4(M6Cl18) (A: ( Ga), In, Tl; M: Nb, Ta).
Authors: BAJAN B. , MEYER H.‐J. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Cs6(Mo7O24)×7 H2O.
Authors: KORTZ U. , POPE M. T. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.