bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Copper‐Catalyzed Asymmetric 1,4‐Hydroboration of Coumarins with Pinacolborane: Asymmetric Synthesis of Dihydrocoumarins.
Authors: Kim Hyohyun , Yun Jaesook 
Published: December 2010

AbstractThe addition of pinacolborane to 4‐substituted coumarins in the presence of an optically active copper catalyst affords boron enolates which by reaction with electrophiles give the target dihydrocoumarins.
ChemInform Abstract: Copper‐Catalyzed Olefin Aminoacetoxylation.
Authors: Mancheno Danny E. , Thornton Aaron R. , Stoll Armin H. , Kong Aidi , Blakey Simon B. 
Published: December 2010

AbstractTerminal olefin substrates are cyclized with PhI(OAc)2 as an oxidant with the formation of 3‐acetoxypiperidine predominantly [cf.
ChemInform Abstract: Carbonic Anhydrase Inhibitors. Regioselective Synthesis of Novel 1‐Substituted 1,4‐Dihydro‐4‐oxo‐3‐pyridinesulfonamides and Their Inhibition of the Human Cytosolic Isozymes I and II and Transmembrane Cancer‐Associated Isozymes IX and XII.
Authors: Brzozowski Zdzislaw , Slawinski Jaroslaw , Innocenti Alessio , Supuran Claudiu T. 
Published: December 2010

AbstractA series of novel 1‐substituted 1,4‐dihydro‐4‐oxo‐3‐pyridinesulfonamides of type (III), (V) and (VII) is prepared and their inhibition of the human cytosolic isozymes I and II and transmembrane cancer‐associated isozymes II and XII is tested.
ChemInform Abstract: Synthesis and Pharmacological Evaluation of Condensed Heterocyclic 6‐Substituted 1,2,4‐Triazolo‐[3,4‐b]‐1,3,4‐thiadiazole and 1,3,4‐Oxadiazole Derivatives of Isoniazid.
Authors: Gilani Sadaf J. , Khan Suroor A. , Siddiqui Nadeem 
Published: December 2010

AbstractAll synthesized substances are evaluated for their anti‐inflammatory, analgesic, ulcerogenic, and lipid peroxidation activities.
ChemInform Abstract: Design, Synthesis and Antimicrobial Activities of Some New Quinoline Derivatives Carrying 1,2,3‐Triazole Moiety.
Authors: Thomas K. D. , Adhikari Airody Vasudeva , Shetty N. Suchetha 
Published: December 2010

Abstract25 title compounds of type (IX) are prepared and tested for their antibacterial and antifungal activities.
ChemInform Abstract: An Expedient Synthesis of Indolo[1,2‐a]quinolines via Mn(OAc)3‐Mediated Oxidative Free Radical Cyclization and NaI/O2‐Assisted Dealkoxycarbonylation/Aerobic Oxidation Cascade.
Authors: Lee Hyun Seung , Kim Se Hee , Kim Yu Mi , Kim Jae Nyoung 
Published: December 2010

AbstractTwo different approaches are developed for the preparation of the biologically important target heterocycles.
ChemInform Abstract: Synthesis of Methyl‐Substituted 1,7‐Phenanthroline Derivatives by Condensation of 2‐Methylquinolin‐5‐amine with Aromatic Aldehydes and Cyclic 1,3‐Diketones.
Authors: Kozlov N. G. , Gusak K. N. 
Published: December 2010

AbstractA convenient three‐component one‐pot procedure for the synthesis of difficultly accessible methyl‐substituted 1,7‐phenanthroline derivatives (IV) (16 examples) is developed.
ChemInform Abstract: Remarkable Facilitation of Hetero‐Cycloisomerizations with Water and Other Polar Protic Solvents: Metal‐Free Synthesis of Indolizines.
Authors: Narayan Alison R. Hardin , Sarpong Richmond 
Published: December 2010

AbstractIndolizines are obtained in hetero‐cycloisomerization reactions of propargylic alcohol derivatives in the presence of pure water, without the use of any metal catalyst, additive, and toxic organic solvent.
ChemInform Abstract: Regioselective Synthesis and Molecular Modeling Study of Vasorelaxant Active 7,9‐Dioxa‐1,2‐diaza‐spiro[4.5]dec‐2‐ene‐6,10‐diones.
Authors: Girgis Adel S. , Ismail Nasser S. M. , Farag Hanaa , El‐Eraky Wafaa I. , Saleh Dalia O. , Tala Srinivasa R. , Katritzky Alan R. 
Published: December 2010

AbstractRegioselective 1,3‐dipolar cycloaddition of nitrilimines, generated in situ from hydrazonoyl chloride (II) to (I) yields 12 spiro compounds of type (III).
ChemInform Abstract: Synthesis and Biological Screening of 7‐Alkyl‐3,3a,4,5‐tetrahydroisoxazolo[3,4‐d]pyridazines and 3‐Chloromethyl‐7‐methyl‐3a,4‐dihydro‐3H‐isoxazolo[3,4‐d][1,2]oxazine.
Authors: Naqvi Tahira , Kapoor Kamal K. , Sharma Rattan Lal 
Published: December 2010

AbstractNovel heterocycles are synthesized and screened for their antibacterial and antifungal activity.
ChemInform Abstract: One‐Pot Synthesis of Substituted Pyrimidine Derivatives from Acetylenedicarboxylate, Amine and Orthoformate.
Authors: Nagarajan Arasampattu S. , Reddy Boreddy S. R. 
Published: December 2010

AbstractThe simple procedure allows an efficient synthesis of the pharmaceutically important heterocyclic skeleton (16 examples).
ChemInform Abstract: Asymmetric Organocatalytic Tandem Reaction to Chiral Pyrimidinone Derivatives Using Urea as Dinitrogen Source.
Authors: He Zhao‐Quan , Zhou Quan , Wu Li , Chen Ying‐Chun 
Published: December 2010

AbstractThe optically active pyrimidones are prepared via an aza‐Michael addition—hemiaminal formation—dehydroxylation reaction using a chiral prolinol O‐Tms ether as catalyst.
ChemInform Abstract: Synthesis and Suzuki—Miyaura Reactions of 5‐Halo‐3,4‐dihydropyrimidin‐2(1H)‐ones.
Authors: Zych Andrew J. , Wang Hong‐Jun , Sakwa Samuel A. 
Published: December 2010

AbstractHalo derivatives of type (VI) and (XI) are prepared via the corresponding carboxylic acids following a treatment with NaI or NaBr under conditions A).
ChemInform Abstract: Thiophenol‐Mediated Radical Cyclization: An Expedient Approach to 2H‐Pyrrolo[3,2‐d]pyrimidines (9‐Deazaxanthine Analogues).
Authors: Majumdar K. C. , Mondal Shovan , Ghosh Debankan 
Published: December 2010

AbstractTreatment of diones (I) and mixed ‐Me/‐Et analogues affords the target compounds (III)(6 examples) in moderate yields.
ChemInform Abstract: Diastereo‐ and Enantioselective Gold(I)‐Catalyzed Intermolecular Tandem Cyclization/[3 + 3]Cycloadditions of 2‐(1‐Alkynyl)‐2‐alken‐1‐ones with Nitrones.
Authors: Liu Feng , Qian Deyun , Li Lei , Zhao Xiaoli , Zhang Junliang 
Published: December 2010

AbstractOptically active heterobicyclic furo[3,4‐d][1,2]oxazines are obtained by the present new asymmetric gold(I)‐catalyzed cycloaddition of 2‐(1‐alkynyl)‐2‐alken‐1‐ones with nitrones.
ChemInform Abstract: Syntheses on the Basis of Diethyl (2‐Morpholinoethyl)malonate.
Authors: Mesropyan E. G. , Galstyan A. S. , Avetisyan A. A. , Ambartsumyan G. B. 
Published: December 2010

AbstractNew functionally substituted butan‐4‐olides and 5‐[2‐(morpholino)ethyl]barbituric and ‐thiobarbituric acids are synthesized starting from diester (III).
ChemInform Abstract: Synthesis and Antioxidant Activity of Quinolinobenzothiazinones.
Authors: Kumar M. , Sharma Kshitija , Samarth R. M. , Kumar A. 
Published: December 2010

AbstractTitle compounds (III) are evaluated for their antioxidant activity by radical scavenging (DPPH) and ABTS radical cation decolorization assays.
ChemInform Abstract: A Novel Series of [3.2.1] Azabicyclic Biaryl Ethers as α3β4 and α6/4β4 Nicotinic Receptor Agonists.
Authors: Lowe John A. III , et al. et al. 
Published: December 2010

AbstractKey steps in the presented strategy are a diastereoselective Mitsunobu reaction to (III) followed by Suzuki coupling to (V).
ChemInform Abstract: Expeditious Synthesis of Imidazole‐ and Pyrrole‐Fused Benzodiazocines.
Authors: Mishra Amita , Batra Sanjay 
Published: December 2010

AbstractThe synthesis of benzodiazocines (VI) involves Horner—Wadsworth—Emmons olefination of an N‐(o‐nitrophenyl)imidazolecarbaldehyde or the pyrrole analogue (I) followed by reduction of nitro group and olefin double bond and cyclization reaction.
ChemInform Abstract: Diversity‐Oriented Microwave‐Assisted Synthesis of the 3‐Benzazepine Framework.
Authors: Peshkov Vsevolod A. , Pereshivko Olga P. , Donets Pavel A. , Mehta Vaibhav P. , Van der Eycken Erik V. 
Published: December 2010

AbstractTitle synthesis involves a microwave‐assisted three‐component reaction of an amine with an aldehyde and a terminal alkyne or two equivalents of alkyne, followed by Pd‐catalyzed microwave‐assisted cyclization.
ChemInform Abstract: Synthesis and Antibacterial Activity of Some Novel 6‐(1H‐Benz [d]imidazol‐2‐yl)‐8‐(5‐nitro‐2‐furyl)‐3‐(4‐pyridyl)‐7,8‐dihydro [1,2,4]triazolo[3,4‐b][1,3,4]thiadiazepines.
Authors: Reddy Vanga Malla , Reddy Kunduru Ravinder 
Published: December 2010

AbstractThe title compounds (VIII) exhibit weak antimicrobial and antifungal activity.
ChemInform Abstract: Cyclopalladated Ferrocenylimine as Efficient Catalyst for the Syntheses of Arylboronate Esters.
Authors: Wang Lianhui , Li Jingya , Cui Xiuling , Wu Yusheng , Zhu Zhiwu , Wu Yangjie 
Published: December 2010

AbstractBoth aryl/heteroaryl bromides and chlorides undergo the coupling reaction with diboron compound (III) in the presence of PCy3 catalyst (Ia) and biphenylphosphino catalyst (Ib), respectively, under optimized conditions.
ChemInform Abstract: Efficient Method to Prepare Diethylphosphonacetamides.
Authors: Scaravelli Federico , Bacchi Sergio , Massari Luca , Curcuruto Ornella , Westerduin Pieter , Maton William 
Published: December 2010

AbstractAcid (I) reacts with various amines and N‐heterocycles such as the oxazolidinone (IV) in the presence of T3P as coupling reagent.
ChemInform Abstract: Silica Gel and Polystyrene Supported Aluminum Chloride as Heterogeneous Catalysts for the Preparation of α‐Aminophosphonates.
Authors: Boroujeni Kaveh Parvanak , Shirazi Amir Nasrolahi 
Published: December 2010

AbstractAluminum chloride supported on silica gel or cross‐linked polystyrene is an environmentally‐friendly heterogeneous catalyst for the synthesis of α‐aminophosphonates via three‐component condensation of carbonyl compounds with amines and diethyl phosphite.
ChemInform Abstract: New Cyclization of 4‐Oxahepta‐1,6‐diynes Bearing Sulfur and Selenium Functional Groups.
Authors: Yoshimatsu Mitsuhiro , Watanabe Hiroyasu , Koketsu Eri 
Published: December 2010

AbstractA variety of 1‐sulfanyl and 1‐selanyl derivatives are reacted with sodium alkoxides or thiolates to afford the corresponding trisubstituted furan derivatives with high yields [cf.
ChemInform Abstract: Two New Sesquiterpenes from the Fungus Stereum sp.
Authors: Liu Fang‐Fang , Li Guo‐Hong , Yang Zhong‐Shan , Zheng Xi , Yang Yue , Zhang Ke‐Qin 
Published: December 2010

AbstractThe isolation and structure elucidation of two novel sesquiterpenes, stereumin F (I) and G (II), are reported.
ChemInform Abstract: Enantioselective Rearrangement of Proline Sulfonamides: An Easy Entry to Enantiomerically Pure α‐Aryl Quaternary Prolines.
Authors: Foschi Francesca , Landini Dario , Lupi Vittoria , Mihali Voichita , Penso Michele , Pilati Tullio , Tagliabue Aaron 
Published: December 2010

AbstractA highly enantioselective rearrangement of proline‐derived sulfonamides proceeds in the presence of base to give α‐arylprolines with a quaternary stereocenter in up to 96% optical purity.
ChemInform Abstract: Total Synthesis and Biological Evaluation of Tambjamine K and a Library of Unnatural Analogues.
Authors: Aldrich Leslie N. , Stoops Sydney L. , Crews Brenda C. , Marnett Lawrence J. , Lindsley Craig W. 
Published: December 2010

AbstractTambjamine K (VII a) exhibits antiproliferative and cytotoxic effects against different tumor and non‐tumor cell lines.
ChemInform Abstract: Synthesis of the C‐1 to C‐18 Fragment of Pamamycins 607 and 621A.
Authors: Ren Guobao , Wu Yikang 
Published: December 2010

AbstractThe cross metathesis reaction between substrates (I) and (II) representing segments C‐1 to C‐4 and C‐5 to C‐18, resp., as a considered strategy for the synthesis of the title C‐1 to C‐18 fragment fails.
ChemInform Abstract: Regioselective Hydrostannation of Diarylalkynes Directed by a Labile ortho Bromine Atom: An Easy Access to Stereodefined Triarylolefins, Hybrids of Combretastatin A‐4 and Isocombretastatin A‐4.
Authors: Rasolofonjatovo Evelia , Provot Olivier , Hamze Abdallah , Bignon Jerome , Thoret Sylviane , Brion Jean‐Daniel , Alami Mouad 
Published: December 2010

AbstractA series of 7 triarylolefins of type (VII) or (VIII) bearing the combretastatin A‐4 and isocombretastatin A‐4 core are prepared.
ChemInform Abstract: Stereoselective Synthesis and Biological Evaluation of (R)‐Rugulactone, (6R)‐((4R)‐Hydroxy‐6‐phenyl‐hex‐2‐enyl)‐5,6‐dihydro‐pyran‐2‐one and Its 4S Epimer.
Authors: Reddy K. Kumar , Shekhar V. , Prabhakar P. , Babu B. Chinna , Siddhardha B. , Murthy U. S. N. , Venkateswarlu Y. 
Published: December 2010

AbstractEmploying proline‐catalyzed α‐aminooxylation and inversion by Mitsunobu reaction as key chirality‐inducing steps, title compounds (VIII), (R)‐rugulactone (IX), and (X) are prepared.
ChemInform Abstract: A Total Synthesis of Natural Rhizobialide.
Authors: Guan Jing , Zou Yang , Gao Po , Wu Yikang , Yue Zhengyu 
Published: December 2010

AbstractStarting from (S)‐glutamic acid as source of the stereogenic center, the natural butanolide rhizobialide (I) is synthesized in enantiopure form for the first time confirming the absolute configuration of (I).
ChemInform Abstract: Synthesis of Talosin A and B, Two Bioactive Isoflavonoid Glycosides.
Authors: Wu Zhongtao , Lian Gaoyan , Yu Biao , Wang Zhenzhong , Zhao Yiwu , Xiao Wei 
Published: December 2010

AbstractTalosin A (Ia) and B (Ib), two genistein 6‐deoxy‐α‐L‐talopyranosides with excellent antifungal and anti‐inflammatory activities, are synthesized for the first time.
ChemInform Abstract: A Highly Efficient and Selective Turn‐on Fluorescent Sensor for Cu2+ Ion.
Authors: Wang Xuehua , Cao Jing , Chen Chuanfeng 
Published: December 2010

AbstractA new fluorescent chemosensor (I) based on an open‐chain azacrown bearing a quinoline moiety is synthesized in a four‐step procedure starting from 2‐nitrophenol.
ChemInform Abstract: Synthesis and Antifungal Evaluation of Novel Triazole Derivatives as Inhibitors of Cytochrome P450 14α‐Demethylase.
Authors: Yu Shichong , Chai Xiaoyun , Hu Honggang , Yan Yongzheng , Guan Zhongjun , Zou Yan , Sun Qingyan , Wu Qiuye 
Published: December 2010

AbstractNovel fluconazole analogues (I) are obtained via click reaction approach at which the 1,4‐disubstituted regioisomers are formed exclusively in the final step.
ChemInform Abstract: The Design of Fluorescent Ratiometric Nanosensors
Authors: Doussineau Tristan , Schulz Anja , Lapresta‐Fernandez Alejandro , Moro Artur , Koersten Susanne , Trupp Sabine , Mohr Gerhard J. 
Published: December 2010

AbstractReview: 50 refs.
e‐WOM scale : Une échelle de mesure du bouche‐à‐oreille dans un contexte de services électroniques
Authors: Goyette Isabelle , Ricard Line , Bergeron Jasmin , Marticotte François 
Published: December 2010

AbstractDrawing data from a survey of 218 consumers across two samples, we developed a measurement scale of the word‐of‐mouth construct (e‐WOM scale) in the context of electronic service. A battery of statistical tests indicated that the WOM construct encompasses four dimensions: WOM intensity, WOM positive behaviours, WOM negative behaviours, and WOM content. Our contribution lies in offering a WOM scale that can be used as a strategic tool for business managers aiming to improve their word‐of‐mouth marketing strategies. Copyright © 2010 ASAC. Published by John Wiley & Sons, Ltd.
Myocardial Performance Index Suggests Optimal Fluid Loss During Hemodialysis
Authors: Papadopoulou Elektra S. , Toumanidis Savvas T. , Tsirpanlis George , Trika Chrisanthi O. , Kalatzopoulou Garyfalia , Moulopoulos Spyridon D. 
Published: December 2010

AbstractBackgroundPatients on long‐term maintenance hemodialysis (HD) are at high risk of developing cardiovascular disease and suffering various cardiovascular complications during HD.HypothesisThe purpose of this study was to evaluate the influence of changing loading conditions on the myocardial performance index (MPI) in patients on long‐term HD and to specify an optimal level of fluid loss during HD that would maintain stable global cardiac function.MethodsThe study consisted of 52 patients with end‐stage renal failure (ESRF), mean age 56±11.7 y, range: 25–80 y, on regular HD. For each patient a complete echocardiographic‐Doppler examination was performed before and after HD. Systolic and diastolic parameters of left ventricular function were measured, and the myocardial performance index (MPI) was calculated.ResultsThe MPI was significantly prolonged after HD (0.47±0.15 before HD versus 0.59±0.16 after HD, p < 0.001). Mean change in body weight during HD was 2.1±0.86 kg. The MPI did not change significantly in patients with intradialytic weight loss up to 1.75 kg.ConclusionsThe MPI value seems to be independent of acute preload changes only when fluid loss is less than 1.75 kg. A 1.75‐kg fluid loss during HD seems to be the optimal goal. In ESRF patients on HD, the MPI seems to be a good indicator of global left ventricular function and potentially a valuable aid in the effort to maintain optimal fluid balance.The authors have no funding, financial relationships, or conflicts of interest to disclose.
Effects of the Aging Process on Left Ventricular Systolic and Diastolic Synchronicity Indexes: Insights From 160 “Completely” Healthy Volunteers
Authors: Kim Hyung‐Kwan , Sohn Dae‐Won , Chang Sung‐A , Park Keun‐Ho , Park Jin‐Shik , Kim Yong‐Jin , Oh Byung‐Hee , Park Young‐Bae 
Published: December 2010

AbstractBackgroundGrowing attempt to use left ventricular (LV) systolic (LVSIsys) and diastolic (LVSIdia) synchronicity indexes in the process of selecting potential responders to cardiac resynchronization therapy has created a need for normative reference values.HypothesisThis study sought: (1) to determine normal reference ranges for LVSIsys and LVSIdia, and (2) to assess their relationships to age and conventional parameters reflecting LV systolic and diastolic functions.MethodsWe recruited 160 healthy volunteers (104 men) free of any systemic or cardiovascular disease. Maximal difference and standard deviation of time to peak systolic and peak early diastolic myocardial velocities for LVSIsys and LVSIdia were measured using 6 and 12 segment models.ResultsNormal ranges for LVSIsys and LVSIdia obtained in this study were slightly higher than previously reported. The normal aging process did not significantly change LVSIsys, whereas LVSIdia progressively and consistently increased with age. Significant correlations were observed between LVSIdia and parameters representing LV diastolic function, that is, early mitral inflow velocity and its deceleration time, and early mitral annulus velocity. A physiologic increase in LV mass/Ht2.7 showed a weak, but significant correlation with LVSIdia (r = 0.15–0.22), but not with LVSIsys. On multivariate analysis, an age‐dependent increase in LVSIdia was confirmed.ConclusionsIn this study, we propose age‐specific reference ranges for LVSIsys and LVSIdia. LVSIsys remains stable throughout age groups, whereas LVSIdia progressively increases with age. We believe that the reference values provided here will be useful for defining abnormal LV synchronous contraction and relaxation. Copyright © 2010 Wiley Periodicals, Inc.This work was presented in part at the Annual Scientific Session of the American Society of Echocardiography, Seattle, Washington, June 16–20, 2007.
Conversion of Infarction‐Associated Atrial Fibrillation by Restoration of Atrial Perfusion
Authors: Blanton Robert M. , Nappi Anthony , Kimmelstiel Carey D. 
Published: December 2010

AbstractWe report a patient who presented with new onset atrial fibrillation in the setting of inferior ST‐segment elevation myocardial infarction (STEMI). Cardiac catheterization revealed proximal occlusion of the left circumflex artery. Balloon angioplasty and stenting restored flow to a large left atrial branch, with prompt conversion of the rhythm to atrial flutter, and then to sinus rhythm. To our knowledge this represents the first demonstration of restoration of sinus rhythm by reversing left atrial ischemia in the setting of STEMI.
Prevalence of Coronary Artery Anomalies in 12,457 Adult Patients Who Underwent Coronary Angiography
Authors: Yildiz Ahmet , Okcun Baris , Peker Tezcan , Arslan Caner , Olcay Ayhan , Bulent Vatan M. 
Published: December 2010

AbstractBackgroundCoronary artery anomalies are found in 0.2% to 1.3% of patients undergoing coronary angiography and 0.3% of an autopsy series. We aimed to estimate the frequency of coronary artery anomalies in our patient population.MethodsThe data were collected retrospectively by analyzing the angiographic data of 12 457 consecutive adult patients undergoing coronary angiography between September 2002 and October 2007.ResultsCoronary artery anomalies were found in 112 patients (0.9% incidence), 100 patients (89.3%) had origin and distribution anomalies, and 12 patients (10.7%) had coronary artery fistulae. Their mean age was 52 ± 8 years (range, 22–79 y). Separate origins of left anterior descending and left circumflex coronary artery from the left sinus of Valsalva was the most common anomaly (63.4%). The right coronary artery rising from the left coronary sinus of Valsalva was found in 10 (8.9%) patients. Anomalous origin of the left circumflex coronary artery from the right sinus of Valsalva was seen in 10 (8.9%) patients. The left main coronary artery from the right coronary sinus of Valsalva was found in 1 (0.89%) patient while an isolated single coronary artery was seen in 2 (1.78%) patients.ConclusionThe incidence and the pattern of coronary artery anomalies in our patient population were almost identical with previous studies. Cardiologists should be aware of the coronary anomalies which may be associated with potentially serious cardiac events, because recognition of these coronary anomalies is mandatory in order to prescribe appropriate therapy.
Family Coronary Heart Disease: A Call to Action
Authors: Superko H. Robert , Roberts Robert , Garrett Brenda , Pendyala Lakshmana , King III Spencer 
Published: December 2010

AbstractA family history of coronary heart disease (CHD) is an accepted risk factor for cardiovascular events and is independent of common CHD risk factors. Advances in the understanding of genetic influences on CHD risk provide the opportunity to apply this knowledge and improve patient care. Utility of inherited cardiovascular risk testing exists by utilizing both phenotypes and genotypes and includes improved CHD risk prediction, selection of the most appropriate treatment, prediction of outcome, and family counseling. The major impediment to widespread clinical adoption of this concept involves un‐reimbursed staff time, educational needs, access to a standardized and efficient assessment mechanism, and privacy issues. The link between CHD and inheritance is indisputable and the evidence strong and consistent. For clinicians, the question is how to utilize this information, in an efficient manner, in order to improve patient care and detection of high‐risk family members. Copyright © 2010 Wiley Periodicals, Inc.Robert Superko has no conflicts. Lakshmana Pendyala has no conflicts. Brenda Garrett is a consultant for CardioDx. Spencer King has no conflicts.Supported in part by FEMA grant No. 2006‐FP‐01744 and the Cholesterol, Genetics and Heart Disease Institute.