bluuebunny/crossref_metadata_2025_split huggingface dataset:
Applying Ground Penetrating Radar and Electrical Resistivity Tomography for the Detection of Archaeological Structures in a Pre‐Tarascan Classic‐Epiclassic Site, Tingambato, Michoacán, Mexico
Authors: Ortega‐Ramírez J. , Bano M. , Punzo‐Díaz J. L. , Villa Alvarado L. A. , Salas‐Corrales J. L. 
Published: June 2024

ABSTRACTA survey was conducted to investigate buried archaeological remains at Tingambato, a pre‐Tarascan classic‐epiclassic archaeological site located in the north‐central part of the State of Michoacán in western Mexico, using ground‐penetrating radar (GPR) and electrical resistivity tomography (ERT). The aim of this study was to detect the foundations (ancient buried walls) and cavities (tombs), define the geometry of the foundations and correlate construction style and depth with relative chronological buried structures. The survey was carried out on two grids of 15 m × 37 m (Zona Verde) and 10.25 m × 36.5 m (Ballgame court), using a 200 MHz antenna for GPR and Schlumberger‐Wenner arrays for ERT. GPR 3D acquisition was carried out along parallel lines spaced 0.25 m apart in a single direction. In the first area, considering the geometric shape found at a depth of 1.35 m, we can assume the existence of a buried structure, probably wall remains. In the second area, a very diffractive zone coincides with a resistive anomaly (> 2000 ohm·m). In order to refine the GPR results, synthetic modelling and a comparison with real traces were carried out. The 1D GPR modelling allows us to precise the presence of a cavity with a rectangular cross section. Since the type of volcaniclastic avalanche deposits of the subsoil do not allow the formation of cavities of that size, we infer that it may be the remains of a tomb or an anthropogenic cavity.
High‐Performance Zinc Anode Enabled by Zincophilic and Hydrophobic ZnO@Nitrogen‐Doped Carbon/MXene Interface
Authors: Wang Yue , Zhu Qizhen , Li Yanze , Ju Yuan , Yang Yong , Xu Bin 
Published: June 2024

AbstractAqueous zinc‐ion batteries (AZIBs) are one of the most promising systems for large‐scale energy storage, but their zinc metal anodes suffer from unsatisfactory stability and reversibility due to the uncontrollable Zn dendrite growth and undesirable side reactions. Herein, a ZnO‐anchored nitrogen‐doped carbon/Ti3C2Tx MXene composite (ZnO@NC/MXene) is developed as a protective layer onto the zinc anode, which establishes a zincophilic and hydrophobic interface. In the ZnO@NC/MXene layer, the nitrogen sites efficiently enhances the adsorption of Zn2+, the ZnO provides homogenous nucleation sites for Zn2+ deposition, and the highly conductive MXene ensures even electric field distribution, synergistically inhibiting the zinc dendrites. Additionally, the hydrophobic ZnO@NC/MXene layer suppresses side reactions by limiting contact between the Zn anode and active water. Therefore, the Zn electrode modified by the ZnO@NC/MXene layer shows remarkable stability with a cycle life of over 2600 h in Zn||Zn symmetric cell and outstanding reversibility with an average coulombic efficiency of 99.37 % for over 1000 cycles in Zn||Cu asymmetric cell. Coupled with V2O5 cathode, the full cell reveals excellent cycle stability of exceeding 1000 cycles at 4 A g−1. These results indicate the potential of the zincophilic and hydrophobic ZnO@NC/MXene as a promising interface layer for protecting Zn anode in AZIBs.
Combination of polymeric micelle formulation of TGFβ receptor inhibitors and paclitaxel produces consistent response across different mouse models of Triple‐negative breast cancer
Authors: Vinod Natasha , Hwang Duhyeong , Fussell Sloane Christian , Owens Tyler Cannon , Tofade Olaoluwa Christopher , Benefield Thad S. , Copling Sage , Ramsey Jacob D. , Rädler Patrick D. , Atkins Hannah M. , Livingston Eric E. , Ezzell J. Ashley , Sokolsky‐Papkov Marina , Yuan Hong , Perou Charles M. , Kabanov Alexander V. 
Published: June 2024

AbstractTriple‐negative breast cancer (TNBC) is notoriously difficult to treat due to the lack of targetable receptors and sometimes poor response to chemotherapy. The transforming growth factor beta (TGFβ) family of proteins and their receptors (TGFRs) are highly expressed in TNBC and implicated in chemotherapy‐induced cancer stemness. Here, we evaluated combination treatments using experimental TGFR inhibitors (TGFβi), SB525334 (SB), and LY2109761 (LY) with paclitaxel (PTX) chemotherapy. These TGFβi target TGFR‐I (SB) or both TGFR‐I and TGFR‐II (LY). Due to the poor water solubility of these drugs, we incorporated each of them in poly(2‐oxazoline) (POx) high‐capacity polymeric micelles (SB‐POx and LY‐POx). We assessed their anticancer effect as single agents and in combination with micellar PTX (PTX‐POx) using multiple immunocompetent TNBC mouse models that mimic human subtypes (4T1, T11‐Apobec and T11‐UV). While either TGFβi or PTX showed a differential effect in each model as single agents, the combinations were consistently effective against all three models. Genetic profiling of the tumors revealed differences in the expression levels of genes associated with TGFβ, epithelial to mesenchymal transition (EMT), TLR‐4, and Bcl2 signaling, alluding to the susceptibility to specific gene signatures to the treatment. Taken together, our study suggests that TGFβi and PTX combination therapy using high‐capacity POx micelle delivery provides a robust antitumor response in multiple TNBC subtype mouse models.
The importance of diversity and inclusion within the research supervision relationship: The views of research students and supervisors
Authors: Bager‐Charleson Sofie , McBeath Alistair , Charura Divine , Symons Clare 
Published: June 2024

AbstractIntroductionResearch supervisors are uniquely positioned to recognise student abilities and needs. This mixed methods study explores how research supervision can support counselling, psychotherapy and counselling psychology doctoral students in their development of new knowledge, with diversity‐related opportunities and challenges in mind.MethodsGuided by ‘dialectical pragmatism’, we used a semi‐qualitative online survey, Reflective Online Practitioner Survey (ROPS; McBeath, 2020), with closed and open questions disseminated across learning institutes in the UK, Europe and North America.ResultsThe survey received 105 responses, with 45 coming from research supervisors and 60 from research students. Only a minority considered their own research supervision team to be diverse, and two‐thirds of respondents did not see matters relating to diversity and inclusion receiving sufficient emphasis in published research.ConclusionsBoth our quantitative and qualitative data addressed unequal representations in terms of gender and sexuality, ethnicity and heritage, (dis‐)ability and social class—several referring to a ‘history of domination by white, cis, non‐disabled male perspectives’. Many described ‘diversity being left out of research’ with consequences on the capacity to meet clients' need in clinical practice. As one said: ‘we need to decolonise the training material by critically analysing and situating knowledge and calling out missing voices’. Another stated: ‘If the research we conduct and draw on as practitioners cannot actively reckon with oppression within…we risk furthering the violence that marginalised clients, practitioners, and researchers face’. Support and training of supervisors to address diversity and power in research from the start of supervision were argued as essential, with both the supervisory relationship and innovative epistemological angles to knowledge and ‘reality’ in the field of mental health in mind.
Recent Advancements in Metal‐Catalyst‐Free Multicomponent Radical Sulfonylation of Alkynes
Authors: Yi Rongnan , Li Qiang , Liu Hongxin , Wei Wen‐Ting 
Published: June 2024

AbstractVinyl sulfones are crucial building blocks in synthetic chemistry and core structural units of pharmaceutically active molecules, thus extensive investigations have been conducted on the construction of these skeletons. In contrast to the classical synthetic approaches, the radical sulfonylation of alkynes for producing vinyl sulfones has garnered considerable interest because of its mild conditions and high efficiency. Radical sulfonation of alkynes typically begins with the sulfonyl radical attacking the alkynes, followed by further functionalization. Moreover, the association of metal‐catalyst‐free systems with multicomponent reactions (MCRs) offers an environmentally friendly pathway for efficiently constructing complex scaffolds from readily available partners. However, there is no comprehensive review summarizing the advancements in metal‐catalyst‐free multicomponent radical sulfonylation of alkynes. Hence, we provide a categorical overview based on the objects of sulfonylation of alkynes (hydrosulfonylation, carbosulfonylation, aminosulfonylation, oxysulfonylation, sulfosulfonylation, selenosulfonylation, and iodosulfonylation), along with interpretations of the reaction mechanisms.
Green innovation and financial performance. The role of R&D investments and ESG disclosure
Authors: Casciello Raffaela , Santonastaso Rosalinda , Prisco Martina , Martino Ilaria 
Published: June 2024

AbstractThis study investigates the effects of green innovation (GI) on financial performance under both accounting and market‐based perspectives in European Union (EU) listed non‐financial firms. In addition, this study explores whether the R&D investments and the Environmental, Social and Governance (ESG) disclosure play a mediating role over the association between GI and accounting‐based and market‐based financial performance, respectively. Based on a sample of 526 firms over the period 2012–2022, we find that GI is negatively associated with accounting‐based financial performance and positively associated with market‐based financial performance. We further find that GI impacts on accounting‐based financial performance via the channel of R&D investments and on market‐based financial performance via the channel of ESG disclosure. This study provides useful contributions to prior research by encouraging the adoption of an integrated perspective when evaluating potential effects of GI. This study can also assist managers in better preparing for the challenges of implementing GI by leveraging the ESG disclosure. It also advices to investors to carefully assess the more complex impact of GI on financial performance of the firm within their capital allocation decision‐making process. In the same vein, it offers some insights to policy makers interested in facilitating the transition to a sustainable economy.
Constructing Built‐in‐Electric Field for Boosting Electrocatalytic Water Splitting
Authors: Yang Huimin , Ni Chunmei , Gao Xuena , Lin Shaohao , He Xiaoyan , Tian Lin , Li Zhao 
Published: June 2024

AbstractElectrocatalytic water splitting shows great potential for producing clean and green hydrogen, but it is hindered by slow reaction kinetics. Advanced electrocatalysts are needed to lower the energy barriers. The establishment of built‐in electric fields (BIEF) in heterointerfaces has been found to be beneficial for speeding up electron transfer, increasing electrical conductivity, adjusting the local reaction environment, and optimizing the chemisorption energy with intermediates. Engineering and modifying the BIEF in heterojunctions offer significant opportunities to enhance the electronic properties of catalysts, thus improving the reaction kinetics. This comprehensive review focuses on the latest advances in BIEF engineering in heterojunction catalysts for efficient water electrolysis. It highlights the fundamentals, engineering, modification, characterization, and application of BIEF in electrocatalytic water splitting. The review also discusses the challenges and future prospects of BIEF engineering. Overall, this review provides a thorough examination of BIEF engineering for the next generation of water electrolysis devices.
Characterisation of circulating tumor‐associated and immune cells in patients with advanced‐stage non‐small cell lung cancer
Authors: Yaghoubi Naei Vahid , Ivanova Ekaterina , Mullally William , O'Leary Connor G , Ladwa Rahul , O'Byrne Ken , Warkiani Majid E , Kulasinghe Arutha 
Published: June 2024

AbstractObjectivesGlobally, non‐small cell lung cancer (NSCLC) is the most prevalent form of lung cancer and the leading cause of cancer‐related deaths. Tumor‐associated circulating cells in NSCLC can have a wide variety of morphological and phenotypic characteristics, including epithelial, immunological or hybrid subtypes. The distinctive characteristics and potential clinical significance of these cells in patients with NSCLC are explored in this study.MethodsWe utilised a spiral microfluidic device to enrich large cells and cell aggregates from the peripheral blood samples of NSCLC patients. These cells were characterised through high‐resolution immunofluorescent imaging and statistical analysis, correlating findings with clinical information from our patient cohort.ResultsWe have identified varied populations of heterotypic circulating tumor cell clusters with differing immune cell composition that included a distinct class of atypical tumor‐associated macrophages that exhibits unique morphology and cell size. This subtype's prevalence is positively correlated with the tumor stage, progression and metastasis.ConclusionsOur study reveals a heterogeneous landscape of circulating tumor cells and their clusters, underscoring the complexity of NSCLC pathobiology. The identification of a unique subtype of atypical tumor‐associatedmacrophages that simultaneously express both tumor and immune markers and whose presence correlates with late disease stages, poor clinical outcomes and metastatic risk infers the potential of these cells as biomarkers for NSCLC staging and prognosis. Future studies should focus on the role of these cells in the tumor microenvironment and their potential as therapeutic targets. Additionally, longitudinal studies tracking these cell types through disease progression could provide further insights into their roles in NSCLC evolution and response to treatment.
Sex‐specific associations of the maturation locus vgll3 with exploratory behavior and boldness in Atlantic salmon juveniles
Authors: Bangura Paul Bai , Tiira Katriina , Aykanat Tutku , Niemelä Petri T. , Erkinaro Jaakko , Liljeström Petra , Toikkanen Anna , Primmer Craig R. 
Published: June 2024

AbstractStudies linking genetics, behavior and life history in any species are rare. In Atlantic salmon (Salmo salar), age at maturity is a key life‐history trait and associates strongly with the vgll3 locus, whereby the vgll3*E allele is linked with younger age at maturity, and higher body condition than the vgll3*L allele. However, the relationship between this genetic variation and behaviors like boldness and exploration which may impact growth and reproductive strategies is poorly understood. The pace‐of‐life syndrome (POLS) framework provides predictions, whereby heightened exploratory behavior and boldness are predicted in individuals with the early maturation‐associated vgll3 genotype (EE). Here, we tested these predictions by investigating the relationship between vgll3 genotypes and exploration and boldness behaviors in 129 juveniles using the novel environment and novel object trials. Our results indicated that contrary to POLS predictions, vgll3*LL fish were bolder and more explorative, suggesting a genotype‐level syndrome including several behaviors. Interestingly, clear sex differences were observed in the latency to move in a new environment, with vgll3*EE males, but not females, taking longer to move than their vgll3*LL counterparts. Our results provide further empirical support for recent calls to consider more nuanced explanations than the pace of life theory for integrating behavior into life‐history theory.
Small‐ to medium‐sized mammals show greater morphological disparity in cervical than lumbar vertebrae across different terrestrial modes of locomotion
Authors: Taewcharoen Nuttakorn , Norris Rachel , Sherratt Emma 
Published: June 2024

AbstractDuring mammalian terrestrial locomotion, body flexibility facilitated by the vertebral column is expected to be correlated with observed modes of locomotion, known as gait (e.g., sprawl, trot, hop, bound, gallop). In small‐ to medium‐sized mammals (average weight up to 5 kg), the relationship between locomotive mode and vertebral morphology is largely unexplored. Here we studied the vertebral column from 46 small‐ to medium‐sized mammals. Nine vertebrae across cervical, thoracic, and lumbar regions were chosen to represent the whole vertebral column. Vertebra shape was analysed using three‐dimensional geometric morphometrics with the phylogenetic comparative method. We also applied the multi‐block method, which can consider all vertebrae as a single structure for analysis. We calculated morphological disparity, phylogenetic signal, and evaluated the effects of allometry and gait on vertebral shape. We also investigated the pattern of integration in the column. We found the cervical vertebrae show the highest degree of morphological disparity, and the first thoracic vertebra shows the highest phylogenetic signal. A significant effect of gait type on vertebrae shape was found, with the lumbar vertebrae having the strongest correlation; but this effect was not significant after taking phylogeny into account. On the other hand, allometry has a significant effect on all vertebrae regardless of the contribution from phylogeny. The regions showed differing degrees of integration, with cervical vertebrae most strongly correlated. With these results, we have revealed novel information that cannot be captured from study of a single vertebra alone: although the lumbar vertebrae are the most correlated with gait, the cervical vertebrae are more morphologically diverse and drive the diversity among species when considering whole column shape.
Age, composition and spatial distribution of sandy loess in north‐eastern Germany (Fläming, Brandenburg)
Authors: Kirsten Fabian , Starke Joris , Bauriegel Albrecht , Müller Robert , Jouaux Jens , Lüthgens Christopher , Sinapius Ralf , Hardt Jacob 
Published: June 2024

AbstractThe sandy loess deposits in the lowlands of northern Germany present a valuable sedimentary archive for late Weichselian periglacial geomorphodynamics. While other aeolian sediments from the Late Quaternary, especially loess deposits and sand dunes, have been studied and dated in some detail in the last decades, sandy loess has received less scientific attention with respect to its genesis, composition, age and provenance as well as distribution patterns. In this study, we present detailed results for three sediment sections located on the Fläming ridge in the south of the state of Brandenburg. According to our results from luminescence dating, the sandy loess deposits of this area were deposited during the late MIS 2 (19–14 ka) with a highly variable thickness of at least up to 4 m, followed by a deposition of periglacial coversands shortly thereafter. The sandy loess deposits display a homogeneous geochemical composition and grain size characteristics similar to loess sections in the main loess areas to the west and south. Furthermore, we analysed a large dataset of geological drill data and performed a spatial interpolation of sandy loess distribution in the Western Fläming. Despite the strongly dissected modern landscape of the Fläming ridge which is partly the result of intense Holocene soil erosion processes, general patterns of the original loess distribution could be deduced. Based on these findings, we were able to identify the low‐lying areas to the north and north‐east of the study area to be the most likely source areas for the sandy loess as a result of katabatic winds originating from the Fennoscandian Ice Shield. Thereby, this study yields important insights regarding aeolian transport and deposition patterns under periglacial conditions in the Central European Lowlands.
Research progress of neurovascular units involved in ischemic stroke
Authors: Yang Yu , Tong Hao , Ye Zhuo‐Fan , Xu Zu‐Cai , Tao Tao 
Published: June 2024

AbstractIschemic stroke is the most prevalent cerebrovascular disorder in the clinical setting. It results in associated neurological abnormalities due to a variety of factors, including disruption of cerebral arterial blood flow, hypoxia, and ischemic necrosis of local brain tissues. The neurovascular unit (NVU) is a dynamic structural complex that consists of neurons, glial cells, pericytes, vascular endothelial cells, and the extracellular matrix. Many cells work together to preserve the integrity of the central nervous system (CNS) under physiological conditions. However, following ischemic stroke, NVU homeostasis is disrupted along with the development of tissue ischemia and hypoxia, as well as impaired interactions between various components of the NVU. Collectively, the changes result in increased blood–brain barrier permeability, neuronal dysfunction, and functional destruction of nerve conduction bundles, ultimately leading to the clinical manifestation of neurological deficits including motor, cognitive, and speech impairments that hinder the rehabilitation process. In recent years, with continuously expanding research on ischemic cerebrovascular disease, the role of interconnections between different cells in the NVU in ischemic stroke has received increasing attention. To describe new concepts for the prevention and treatment of ischemic cerebrovascular illnesses, this article reviews the interplay between NVU in the pathogenesis of ischemic stroke.
Successful laparoscopic retroperitoneal tumor resection using mixed reality and guiding marker techniques
Authors: Tohi Yoichiro , Okazoe Homare , Mitamura Katsuya , Osaki Yu , Tanaka Kenichi , Matsuoka Yuki , Nishiyama Yoshihiro , Kanenishi Kenji , Sugimoto Mikio 
Published: June 2024

IntroductionSmall tumors may be difficult to identify visually and require preoperative effort to locate. Recent advancements in mixed reality technology have improved surgical accuracy in various departments. Here, we present the application of mixed reality‐assisted surgery and a guiding marker in the case of small retroperitoneal metastasis of uterine cancer.Case presentationA 67‐year‐old female with a history of uterine cancer had a retroperitoneal metastasis in the lateroconal fascia near the right diaphragm, measuring 2 cm and infiltrating the peritoneum. We performed precise surgical planning using the preoperative mixed reality software “Holoeyes” on a head‐mounted display called HoloLens2. Novel techniques, including ultrasonography‐guided placement of a guiding marker and strategic port‐site placement facilitated by HoloLens2, ensured accurate tumor identification and laparoscopic resection with minimal blood loss and no intraoperative complications.ConclusionThe use of mixed reality‐assisted surgery and a guiding marker effectively enhanced the precision of retroperitoneal tumor resection.