bluuebunny/crossref_metadata_2025_split huggingface dataset:
Looking for the philosopher's stone: Emerging approaches to target the hallmarks of aging in the skin
Authors: Lemaitre Jean‐Marc 
Published: June 2024

AbstractSenescence and epigenetic alterations are two important hallmarks of cellular aging. During aging, cells subjected to stress undergo many cycles of damage and repair before finally entering either apoptosis or senescence, a permanent state of cell cycle arrest. The first biomarkers of senescence to be identified were increased ß‐galactosidase activity and induction of p16INK4a. Another feature of senescent cells is the senescence‐associated secretory phenotype (SASP), a complex secretome containing more than 80 pro‐inflammatory factors including metalloproteinases, growth factors, chemokines and cytokines. The secretome is regulated through a dynamic process involving a self‐amplifying autocrine feedback loop and activation of the immune system. Senescent cells play positive and negative roles depending on the composition of their SASP and may participate in various processes including wound healing and tumour suppression, as well as cell regeneration, embryogenesis, tumorigenesis, inflammation and finally aging. The SASP is also a biomarker of age, biological aging and age‐related diseases. Recent advances in anti‐age research have shown that senescence can be now prevented or delayed by clearing the senescent cells or mitigating the effects of SASP factors, which can be achieved by a healthy lifestyle (exercise and diet), and senolytics and senomorphics, respectively. An alternative is tissue rejuvenation, which can be achieved by stimulating aged stem cells and reprogramming deprogrammed aged cells. These non‐clinical findings will open up new avenues of clinical research into the development of treatments capable of preventing or treating age‐related pathologies in humans.
Are perfectionistic strivings beneficial or detrimental to well‐being and achievement? Tests of procrastination and emotion regulation as moderators
Authors: Lischetzke Tanja , Grommisch Gloria , Prestele Elisabeth , Altstötter‐Gleich Christine 
Published: June 2024

AbstractObjectiveResearchers have called for an approach that examines the conditions under which perfectionistic strivings (PS) may be beneficial or detrimental to psychological functioning. We adopted a self‐regulation perspective and tested whether individual differences in self‐regulation (procrastination, emotion regulation) moderate PS's relationships with achievement and well‐being in an academic/work‐related achievement context.MethodA sample of 183 preservice teachers participated in a study that combined “traditional” longitudinal assessment (six performance situations over a 9‐month period) with repeated ambulatory assessment (measuring well‐being, procrastination, and emotion regulation during a total of 910 preparation phases that preceded performance situations).ResultsMean levels of achievement, well‐being, and emotion regulation were found to be stable over time, whereas procrastination decreased on average across preparation phases. Results from latent variable interaction models indicated that individual differences in intraindividual change in procrastination over time moderated the relationship between PS and well‐being (but not achievement) in the expected direction: The less individuals decreased in procrastination over time, the more negative the relationship between PS and well‐being was. Contrary to expectations, we found no evidence of a moderating effect of emotion regulation.ConclusionThe study contributes to a nuanced perspective on the adaptiveness of PS.
Lessons from the void: What Boltzmann brains teach
Authors: Saad Bradford 
Published: June 2024

AbstractSome physical theories predict that almost all brains in the universe are Boltzmann brains, that is, short‐lived disembodied brains that are accidentally assembled as a result of thermodynamic or quantum fluctuations. Physicists and philosophers of physics widely regard this proliferation as unacceptable, and so take its prediction as a basis for rejecting these theories. But the putatively unacceptable consequences of this prediction follow only given certain philosophical assumptions. This paper develops a strategy for shielding physical theorizing from the threat of Boltzmann brains. The strategy appeals to a form of phenomenal externalism about the physical basis of consciousness. Given that form of phenomenal externalism, the proliferation of Boltzmann brains turns out to be benign. While the strategy faces a psychophysical fine‐tuning problem, it both alleviates cosmological fine‐tuning concerns that attend physics‐based solutions to Boltzmann brain problems and pays explanatory dividends in connection with time's arrow.
Bearing the burden of peace: Intergroup attribution bias and public support for peace provisions
Authors: Godefroidt Amélie , Muradova Lala 
Published: June 2024

AbstractWhat drives public support for peace provisions? Based on intergroup attribution theory, we argue that public support for peace provisions depends on “who bears the burden of peace,” with people wanting to protect their ingroup while holding the outgroup accountable. To examine this claim, we conducted a series of question‐wording experiments with more than 1650 Azerbaijani participants shortly after a deadly resurgence of the Nagorno‐Karabakh war. Our initial findings confirm that support for war crime punishments and monetary reparations decreases when the ingroup stands trial or must pay. Conversely, support increases when these same burdens fall on the outgroup. A follow‐up study shows that these patterns persist for at least 6 months but also reveals a more nuanced perspective. Public support for peace provisions does not automatically decrease when the ingroup bears the cost or increase when the outgroup bears it; rather, it depends on the group‐based implications of the provision under consideration. Taken together, our results underscore the importance of crafting and communicating peace provisions in a tailored manner and the potential of emphasizing burden sharing as an effective strategy for addressing intergroup hostilities and fostering sustainable peace.
Using the institutional grammar to understand collective resource management in a heterogenous cooperative facing external shocks
Authors: Bunders Damion Jonathan , Moor Tine De 
Published: June 2024

AbstractWorker cooperatives in the gig economy can involve large and heterogeneous memberships, which makes them vulnerable to member opportunism depleting collective resources. External shocks may present another challenge for collective resource management. This raises the question of how heterogeneous cooperatives design rules to mitigate opportunistic behavior and whether these rules evolve in the face of external shocks. We study the case of Smart Belgium between 2017 and 2022, thereby covering the COVID‐19 pandemic and new cooperative legislation as external shocks. Building on the institutional grammar methodology, we analyze 412 rules of Smart. The findings indicate that external shocks with sudden resource scarcity do not necessarily motivate rule changes (COVID‐19) while external shocks without an effect on collective resources can motivate rule changes (national policy change). The study also shows what kind of rules heterogeneous cooperatives may design to mitigate opportunism.
Advanced in Every Dimension
Authors: Kurfess Thomas R. , Jablokow Kathryn W. 
Published: June 2024

Abstract
Digital technologies known collectively as Industry 4.0 are transforming manufacturing and are increasing the effectiveness of our workforce, as well as encouraging domestic and local production. This, in turn, expands the local supply chain, providing greater economic prosperity for the nation and local regions. To get the full benefit of these transforming changes, our workforce must be fully trained to leverage all of these advanced technologies.
Emergency medicine residents’ learning curve in diagnosing deep vein thrombosis with 3-point venous point-of-care ultrasound
Authors: Kang Soo Yeon , Jo Ik Joon , Heo Sejin , Chang Hansol , Lee Guntak , Park Jong Eun , Kim Taerim , Lee Se Uk , Kim Min Ji , Yoon Hee 
Published: June 2024

Abstract
Background
Many cases of deep vein thrombosis (DVT) are diagnosed in the emergency department, and abbreviated lower extremity venous point-of-care ultrasound (POCUS) has already shown an accuracy comparable to that of specialists. This study aimed to identify the learning curve necessary for emergency medicine (EM) residents to achieve expertise-level accuracy in diagnosing DVT through a 3-point lower extremity venous POCUS.

Methods
This prospective study was conducted at an emergency department between May 2021 and October 2022. Four EM residents underwent a one-hour POCUS training session and performed DVT assessments in participants with DVT symptoms or confirmed pulmonary embolism. POCUS was performed at three proximal lower extremity sites to evaluate the thrombi presence and vein compressibility, with results validated by specialized radiology ultrasound. Cumulative sum (CUSUM) and the Bush and Mosteller models were used to analyze the learning curve, while generalized estimating equations were used to identify factors affecting diagnostic accuracy.

Results
91 POCUS scans were conducted in 49 patients, resulting in 22% DVT confirmed by specialized venous ultrasound. In the CUSUM analysis, all four EM residents attained a 90% success rate at the common femoral vein, whereas only half achieved this rate when all three sites were considered. According to Bush and Mosteller models, 13–18 cases are required to attain 90–95% diagnostic accuracy. After 10–16 cases, the examination time for each resident decreased, and a 20% increase in examiner confidence was linked to a 2.506-fold increase in the DVT diagnosis accuracy.

Conclusion
EM residents generally required 13–18 cases for 90–95% DVT diagnostic accuracy, but proficiency varied among individuals, particularly requiring more cases for regions outside the common femoral vein.
B3GNT7 regulates mucin O-glycosylation to alleviate colonic inflammation
Authors: Wang Tian , Sun Han , Zhang Minna , Shen Peng , Li Yan 
Published: June 2024

Abstract
Background
B3GNT7, a glycosyltransferase of significant importance that is highly expressed in intestinal epithelial cells, plays a pivotal role in intestinal physiological processes. This study elucidates novel insights into the potential role and underlying mechanisms of B3GNT7 in ulcerative colitis (UC).

Methods
An experimental colitis model was induced using DSS in mice to investigate B3GNT7 expression in the colon via transcriptomics and immunohistochemistry. Bioinformatics analysis was employed to delineate the biological functions of B3GNT7. Additionally, the correlation between the transcription levels of B3GNT7 in colonic tissues from patients with UC, sourced from the IBDMDB database, and the severity of colonic inflammation was analyzed to elucidate potential mechanisms.

Results
The DSS-induced colitis model was successfully established, and transcriptomic analysis identified a marked downregulation of B3GNT7 expression in the colonic tissues compared to the controls. Functional enrichment analysis indicated B3GNT7’s predominant role in mucin O-glycosylation. Protein interaction analysis revealed that B3GNT7 predominantly interacts with members of the mucin MUC family, including MUC2, MUC3, and MUC6. In patients with UC, B3GNT7 transcription levels were significantly reduced, particularly in those with moderate to severe disease activity. The expression level of B3GNT7 exhibited a negative correlation with the endoscopic severity of UC. Gene set enrichment analysis (GSEA) further demonstrated significant enrichment of B3GNT7 in the mucin O-glycosylation synthesis pathway.

Conclusion
The downregulation of B3GNT7 expression in the colonic tissues of UC patients may contribute to the compromised mucin barrier function and the exacerbation of colitis.
Delayed diagnosis of persistent Q fever: a case series from China
Authors: Wang Shanshan , Xu Ke , Wang Gang 
Published: June 2024

Abstract
Background
Q fever, caused by the zoonotic pathogen Coxiella burnetii, exhibits a worldwide prevalence. In China, Q fever is not recognized as a notifiable disease, and the disease is overlooked and underestimated in clinical practice, leading to diagnostic challenges.

Case presentation
We present a case series of three patients diagnosed with persistent Q fever between 2022 and 2023. The average age of our three cases was 63.33 years old, consisting of two males and one female. The medical history of the individuals included previous valve replacement, aneurysm followed by aortic stent-graft placement and prosthetic hip joint replacement. At the onset of the disease, only one case exhibited acute fever, while the remaining two cases were devoid of any acute symptoms. The etiology was initially overlooked until metagenomic next-generation sequencing test identified Coxiella burnetii from the blood or biopsy samples. Delayed diagnosis was noted, with a duration ranging from three months to one year between the onset of the disease and its confirmation. The epidemiological history uncovered that none of the three cases had direct exposure to domestic animals or consumption of unpasteurized dairy products. Case 1 and 2 resided in urban areas, while Case 3 was a rural resident engaged in farming. All patients received combination therapy of doxycycline and hydroxychloroquine, and no recurrence of the disease was observed during the follow-up period.

Conclusion
Q fever is rarely diagnosed and reported in clinical practice in our country. We should be aware of persistent Q fever in high-risk population, even with unremarkable exposure history. Metagenomic next-generation sequencing holds great potential as a diagnostic tool for identifying rare and fastidious pathogens such as Coxiella burnetii.
Robust brain tumor classification by fusion of deep learning and channel-wise attention mode approach
Authors: A.G Balamurugan , Srinivasan Saravanan , D Preethi , P Monica , Mathivanan Sandeep Kumar , Shah Mohd Asif 
Published: June 2024

AbstractDiagnosing brain tumors is a complex and time-consuming process that relies heavily on radiologists’ expertise and interpretive skills. However, the advent of deep learning methodologies has revolutionized the field, offering more accurate and efficient assessments. Attention-based models have emerged as promising tools, focusing on salient features within complex medical imaging data. However, the precise impact of different attention mechanisms, such as channel-wise, spatial, or combined attention within the Channel-wise Attention Mode (CWAM), for brain tumor classification remains relatively unexplored. This study aims to address this gap by leveraging the power of ResNet101 coupled with CWAM (ResNet101-CWAM) for brain tumor classification. The results show that ResNet101-CWAM surpassed conventional deep learning classification methods like ConvNet, achieving exceptional performance metrics of 99.83% accuracy, 99.21% recall, 99.01% precision, 99.27% F1-score and 99.16% AUC on the same dataset. This enhanced capability holds significant implications for clinical decision-making, as accurate and efficient brain tumor classification is crucial for guiding treatment strategies and improving patient outcomes. Integrating ResNet101-CWAM into existing brain classification software platforms is a crucial step towards enhancing diagnostic accuracy and streamlining clinical workflows for physicians.
Pregnancy induced hypertension and umbilical cord blood DNA methylation in newborns: an epigenome-wide DNA methylation study
Authors: Zhu Xiaojun , Jiang Peiyue , Ying Xia , Tang Xueling , Deng Youcai , Gao Xinghong , Yang Xiaofu 
Published: June 2024

Abstract
Objectivies
Pregnancy induced hypertension (PIH) syndrome is a disease that unique to pregnant women and is associated with elevated risk of offspring cardiovascular diseases (CVDs) and neurodevelopmental disorders in their kids. Previous research on cord blood utilizing the Human Methylation BeadChip or EPIC array revealed that PIH is associated with specific DNA methylation site. Here, we investigate the whole genome DNA methylation landscape of cord blood from newborns of PIH mother.

Methods
Whole-genome bisulfite sequencing (WGBS) was used to examine the changes in whole genome DNA methylation in the umbilical cord blood of three healthy (NC) and four PIH individuals. Using methylKit, we discovered Hypo- and hyper- differentially methylated probes (DMPs) or methylated regions (DMRs) in the PIH patients’ cord blood DNA. Pathway enrichments were assessed using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment assays. DMPs or DMRs relevant to the immunological, neurological, and circulatory systems were also employed for enrichment assay, Metascape analysis and PPI network analysis.

Results
520 hyper- and 224 hypo-DMPs, and 374 hyper- and 186 hypo-DMRs between NC and PIH group, respectively. Both DMPs and DMRs have enhanced pathways for cardiovascular, neurological system, and immune system development. Further investigation of DMPs or DMRs related to immunological, neurological, and circulatory system development revealed that TBK1 served as a hub gene for all three developmental pathways.

Conclusion
PIH-associated DMPs or DMRs in umbilical cord blood DNA may play a role in immunological, neurological, and circulatory system development. Abnormal DNA methylation in the immune system may also contribute to the development of CVDs and neurodevelopment disorders.
Impact of health literacy, social support, and socioeconomic position on the serum uric acid level in asymptomatic hyperuricaemia patients in China: a structural equation model
Authors: Jing Yunfang , Ma Lilai , Zhang Yuanfan , Li Xiaohong , Jiang Jun , Long Jie , Ma Ling 
Published: June 2024

Abstract
Background
Hyperuricaemia (HUA) poses a significant public health challenge on a global scale. It is mostly asymptomatic hyperuricemia (AHU) with unsatisfactory recognition and control rates. The role of health literacy in influencing health outcomes is of utmost importance, and enhancing health literacy is helpful for patients in managing risk factors. Additionally, social support and socioeconomic position (SEP) have been identified as potential factors influencing health. However, the exact relationships between these factors and AHU remain unclear. This study aimed to investigate the status of health literacy among patients with AHU and explore the relationships between health literacy, social support, SEP, and serum uric acid (SUA) levels.

Methods
A cross-sectional study was conducted among 349 participants with AHU in Luzhou, China. The research instruments included a sociodemographic characteristics questionnaire, the Health Literacy Scale for Chronic Patients (HLSCP), and the Social Support Scale (SSRS). The construction of the SEP index was achieved through the application of principal component analysis. Univariate and hierarchical regression analyses were used to evaluate the associations between SEP, social support, health literacy, and SUA levels. Furthermore, structural equation modelling (SEM) was utilized to examine these associations.

Results
(1) Most patients exhibited low health literacy (90.18 ± 15.11), and only 44.4% possessed basic health literacy. (2) SEP was positively correlated with SUA levels (β = 4.086, P < 0.001), and health literacy was negatively related to SUA levels (β = -0.399, P < 0.001). There was no significant relationship between social support and SUA levels (β = 0.051, t = 1.085). (3) Health literacy mediated the association between SEP and SUA levels (β = -0.490, 95% CI: -0.620 to -0.382). SEP had a direct positive effect on SUA levels (β = 0.723) and health literacy (β = 0.696), and the total effect of SEP on SUA levels was 0.233.

Conclusions
The findings indicate a low level of health literacy among patients with AHU and suggest that health literacy might play a mediating role in the relationship between SEP and SUA levels. Consequently, future initiatives are recommended to prioritize health literacy and devise appropriate intervention strategies to enhance the self-management capabilities of patients with AHU.
A comparative analysis of sivelestat sodium hydrate and ulinastatin combination therapy in the treatment of sepsis with acute respiratory distress syndrome
Authors: Xu Jian , Zhang Chenfei , Wu Keren , Qian Yanhua , Hu Wei 
Published: June 2024

Abstract
Objective
This comparative analysis aimed to investigate the efficacy of Sivelestat Sodium Hydrate (SSH) combined with Ulinastatin (UTI) in the treatment of sepsis with acute respiratory distress syndrome (ARDS).

Methods
A control group and an observation group were formed with eighty-four cases of patients with sepsis with ARDS, with 42 cases in each group. The control group was intravenously injected with UTI based on conventional treatment, and the observation group was injected with SSH based on the control group. Both groups were treated continuously for 7 days, and the treatment outcomes and efficacy of both groups were observed. The Murray Lung Injury Score (MLIS), Sequential Organ Failure Assessment (SOFA), and Acute Physiology and Chronic Health Evaluation II (APACHE II) were compared. Changes in respiratory function, inflammatory factors, and oxidative stress indicators were assessed. The occurrence of adverse drug reactions was recorded.

Results
The total effective rate in the observation group (95.24%) was higher than that in the control group (80.95%) (P < 0.05). The mechanical ventilation time, intensive care unit (ICU) hospitalization time, and duration of antimicrobial medication in the observation group were shorter and multiple organ dysfunction syndrome incidence was lower than those in the control group (P < 0.05). The mortality rate of patients in the observation group (35.71%) was lower than that in the control group (52.38%), but there was no statistically significant difference between the two groups (P > 0.05). MLIS, SOFA, and APACHE II scores in the observation group were lower than the control group (P < 0.05). After treatment, respiratory function, inflammation, and oxidative stress were improved in the observation group (P < 0.05). Adverse reactions were not significantly different between the two groups (P > 0.05).

Conclusion
The combination of SSH plus UTI improves lung injury and pulmonary ventilation function, and reduces inflammation and oxidative stress in patients with sepsis and ARDS.