bluuebunny/crossref_metadata_2025_split huggingface dataset:
Utilizing partially demineralized dentin plate for horizontal ridge augmentation: A case report
Authors: Refahi Pooyan , Shaikh Samar 
Published: May 2024

AbstractBackgroundThis article intends to showcase a case of guided bone regeneration (GBR) utilizing a partially demineralized dentin plate processed from an extracted second molar for horizontal augmentation of the posterior ridge for implant placement.Methods and ResultsA 60‐year‐old patient presented with horizontal ridge deficiency at site #30 and an endodontically treated tooth #31 with recurrent decay. A treatment plan was proposed to extract tooth #31 and utilize a dentin graft from the tooth for ridge augmentation at site #30. Following the atraumatic extraction of tooth #31, it was sectioned into a 1 mm thick dentin plate, sterilized, and processed to obtain a demineralized dentin graft. Following a mid‐crestal incision and full‐thickness flap elevation, the dentin plate was adapted on the buccal defect of site #30 with 10 mm fixation screws, and the gap between the plate and the buccal bone was filled with 0.5 cc of 50/50 cortico‐cancellous bone allograft hydrated with saline, covered with collagen membrane followed by primary closure. At 6 months, a postoperative cone‐beam computed tomography (CBCT) was obtained to evaluate the ridge width revealing sufficient ridge width for optimal implant placement. The radio‐opaque dentin plate was visible on the CBCT depicting integration with the alveolar ridge. Following surgical implant preparation protocol, a 4 mm diameter and 8.5 mm length implant was placed in a restoratively driven position.ConclusionThis case reports favorable outcomes for GBR using a partially demineralized dentin plate as an alternative to an autogenous bone block graft for horizontal ridge augmentation for future implant placement.Key Points
This case introduces a novel method utilizing partially demineralized dentin plates derived from extracted teeth for guided bone regeneration, showcasing its potential efficacy in addressing ridge deficiencies.
Success, in this case, relies on meticulous sectioning of the tooth and processing of the dentin graft, precise adaptation and fixation of the graft to the residual ridge, and achieving primary closure for undisturbed healing.
Limitations to success include the availability of teeth for extraction coinciding with the need for ridge augmentation and unstable graft fixation.
Combining the Pharmaceutical and Toxicological Properties of Selected Essential Oils with their Chemical Components by GC‐MS Analysis
Authors: Nilofar  , Ahmed Shakeel , Zengin Gokhan , Di Simone Simonetta Cristina , Acquaviva Alessandra , Libero Maria Loreta , Chiavaroli Annalisa , Orlando Giustino , Tacchini Massimo , Di Vito Maura , Menghini Luigi , Ferrante Claudio 
Published: May 2024

AbstractIn the current investigation, a comprehensive analysis was carried out on essential oils (EOs) extracted from six aromatic plant species, namely Rosmarinus officinalis, Pelargonium graveolens, Thymus vulgaris, Origanum vulgare, Laurus nobilis, and Aloysia citrodora. An exploration was conducted into the chemical composition using Gas Chromatography‐Mass Spectrometry (GC/MS), antioxidant properties assessed through DPPH, ABTS, CUPRAC, FRAP, MCA, and PBD assays, ecotoxicological impacts evaluated via allelopathy and the Daphnia magna heartbeat test, as well as bio‐pharmacological effects including anticancer activity and gene expression analysis. Results revealed strong antioxidant activity in all essential oils, with T. vulgaris EO (2748.00 mg TE/g) and O. vulgare EO (2609.29 mg TE/g) leading in CUPRAC assay. R. officinalis EO showed the highest α‐amylase inhibition at 1.58 mmol ACAE/g, while O. vulgare EO excelled in α‐glucosidase inhibition at 1.57 mmol ACAE/g. Additionally, cytotoxic effects were evaluated on human colorectal cancer (HCT116) cells. A. citrodora, O. vulgare, and R. officinalis EOs were found the most potent anticancer, as also witnessed by their higher modulatory effects on the gene expression of BAX and Bcl‐2. Collectively, the present data highlight the importance to implement the knowledge and to valorize the supply chain of aromatic plants.
Synthesis and Dopaminergic Neuroprotective Activity of the Proposed Structure of Bassiamide A, a Caffeamide Alkaloid Derived from Bassia Indica Wight
Authors: Kim Eunyeong , Yang Wooin , Cha Dong Seok , Han Young Taek 
Published: May 2024

AbstractHerein, we describe the synthesis of the proposed structure of the caffeamide alkaloid bassiamide A. The amide moiety of bassiamide A was readily formed via an amide coupling reaction between caffeic acid and the known N‐(3‐aminopropyl)‐3‐methylbutanamide. However, the spectral data of the synthesized bassiamide A did not agree with that of a previous study. The structure of the synthesized bassiamide A was confirmed using combined two‐dimensional NMR analysis. Extended analyses of the bioactivity of the synthesized bassiamide A revealed its efficacy in protecting dopaminergic neurons from MPP+‐induced neurotoxicity in Caenorhabditis elegans. Additionally, treatment with bassiamide A notably ameliorated the impaired food‐sensing ability and locomotion of Caenorhabditis elegans, suggesting a protective effect on the functionality of dopaminergic neurons.
Improvement of Heterologous Soluble Expression of L‐amino Acid Oxidase Using Logistic Regression
Authors: Nakahara Ayuta , Su Zhengyu , Wakayama Mamoru , Nakamura Masaki , Sakakibara Kazutoshi , Matsui Daisuke 
Published: May 2024

AbstractSuccessful implementation of enzymes in practical application hinges on the development of efficient mass production techniques. However, in a heterologous expression system, the protein is often unable to fold correctly and, thus, forms inclusion bodies, resulting in the loss of its original activity. In this study, we present a new and more accurate model for predicting amino acids associated with an increased L‐amino acid oxidase (LAO) solubility. Expressing LAO from Rhizoctonia solani in Escherichia coli and combining random mutagenesis and statistical logistic regression, we modified 108 amino acid residues by substituting hydrophobic amino acids with serine and hydrophilic amino acids with alanine. Our results indicated that specific mutations in Euclidean distance, glycine, methionine, and secondary structure increased LAO expression. Furthermore, repeated mutations were performed for LAO based on logistic regression models. The mutated LAO displayed a significantly increased solubility, with the 6‐point and 58‐point mutants showing a 2.64‐ and 4.22‐fold increase, respectively, compared with WT‐LAO. Ultimately, using recombinant LAO in the biotransformation of α‐keto acids indicates its great potential as a biocatalyst in industrial production.
Understanding transcatheter edge‐to‐edge repair “knobology”: Advanced catheter steering for different scenarios of transseptal puncture
Authors: Russo Giulio , d'Aiello Alessia , Pedicino Daniela , Kuwata Shingo , Sangiorgi Giuseppe Massimo , Taramasso Maurizio , Maisano Francesco 
Published: May 2024

AbstractFollowing the introduction in the latest European and American guidelines, transcatheter edge‐to‐edge repair has become a valid alternative to surgery for ineligible patients. Among the available technologies, MitraClip (Abbott) was the first to be introduced for the percutaneous treatment of mitral regurgitation with the edge‐to‐edge technique. Although its safety and effectiveness has been widely demonstrated, the optimal procedural results are highly dependent from operators' experience. In this manuscript, we provide a full guide of advanced steering maneuvers of MitraClip in different scenarios of transseptal puncture.
The dual orexin receptor antagonist suvorexant in alcohol use disorder and comorbid insomnia: A case report
Authors: Campbell Erin J. , Bonomo Yvonne , Collins Lisa , Norman Amanda , O'Neill Helen , Streitberg Amanda , Galloway Kate , Kyoong Andrew , Perkins Andrew , Pastor Adam , Lawrence Andrew J. 
Published: May 2024

Key Clinical MessageThis case suggests using dual orexin receptor antagonists to treat alcohol use disorder and comorbid sleep disorders may be effective, commencing treatment in withdrawal and continuing it to prevent relapse.AbstractEffective medications for the treatment of alcohol use disorder are limited. This is partially due to the heterogenous nature of the symptomatology associated with alcohol use disorder and the abundance of presenting comorbidities. One common, and often overlooked, symptom that occurs during withdrawal of alcohol use is sleep disruption. Here, we report a case study of a participant with comorbid alcohol use disorder and insomnia. This participant was treated with a dual orexin receptor antagonist, suvorexant (Belsomra®), currently approved to treat insomnia. We demonstrate improvements in alcohol cravings, physical and psychological health, and sleep outcomes with treatment. These data support abundant preclinical and emerging clinical data in this space. The findings from this case report highlight the potential for suvorexant to treat comorbid alcohol use disorder and insomnia with fully powered, randomized controlled trials moving forward.
Direct Mechanocatalysis with Pd Alloys
Authors: Pickhardt Wilm , Kraus Fabien Joel Leon , Wohlgemuth Maximilian , Etter Martin , Spallek Marius , Schwensow Martin , Genç Zeynep , Grätz Sven , Borchardt Lars 
Published: May 2024

AbstractIn this study, we assess the suitability of Pd alloys in direct mechanocatalytic coupling reactions. Copper (Cu) and nickel (Ni) were alloyed with palladium (Pd), alongside testing a high entropy alloy and palladium gold alloy. Compared to pure Pd balls the alloys are promising in terms of mechanical properties and costs. Combining Pd with Cu and Ni improved mechanical resilience by up to 330 % while retaining catalytic activity, for the tested Suzuki‐Miyaura and Sonogashira‐Hagihara couplings. Both of which led to good to excellent yields within one hour. Notably, alloys containing 20 % Pd showed increased yields of over 80 % in the Sonogashira coupling, comparable to pure Pd. XPS and in‐situ PXRD analysis showcased the influence of alloyed metals on catalytic processes, emphasizing the significance of the surface composition of milling balls.
Coupling of Phthalocyanines with Plasmonic Gold Nanoparticles by Click Chemistry for an Enhanced Singlet Oxygen Based Photoelectrochemical Sensing
Authors: Khan Shahid U. , Matshitse Refilwe , Borah Rituraj , Nemakal Manjunatha , Moiseeva Ekaterina O. , Dubinina Tatiana V. , Nyokong Tebello , Verbruggen Sammy W. , De Wael Karolien 
Published: May 2024

AbstractCoupling photosensitizers (PSs) with plasmonic nanoparticles increases the photocatalytic activity of PSs as the localized surface plasmon resonance (LSPR) of plasmonic nanoparticles leads to extreme concentration of light in their vicinity known as the near‐field enhancement effect. To realize this in a colloidal phase, efficient conjugation of the PS molecules with the plasmonic nanoparticle surface is critical. In this work, we demonstrate the coupling of phthalocyanine (Pc) molecules with gold nanoparticles (AuNPs) in the colloidal phase via click chemistry. This conjugated Pc‐AuNPs colloidal system is shown to enhance the photocatalytic singlet oxygen (1O2) production over non‐conjugated Pcs and hence improve the photoelectrochemical detection of phenols. The plasmonic enhancement of the 1O2 generation by Pcs was clearly elucidated by complementary experimental and computational classical electromagnetic models. The dependence of plasmonic enhancement on the spectral position of the excitation laser wavelength and the absorbance of the Pc molecules with respect to the wavelength specific near‐field enhancement is clearly demonstrated. A high ∼ 8 times enhancement is obtained with green laser (532 nm) at the LSPR due to the maximum near‐field enhancement at the resonance wavelength.
Does the Electrical Double Layer Contribute to the Mechanism of Action of Antimicrobial Peptides?
Authors: Juhaniewicz‐Debinska Joanna , Dziubak Damian , Sek Slawomir 
Published: May 2024

AbstractThis concept paper elucidates the possible influence of the electrical double layer (EDL) and the polyelectrolytic nature of bacterial cell walls on the behavior of antimicrobial peptides (AMPs) and lipopeptides. It proposes that the presence of EDL adjacent to lipid membranes may play a crucial role in inducing peptide aggregation and conformational changes, thus affecting their antimicrobial activity. Furthermore, it emphasizes that the negatively charged components in both Gram‐positive and Gram‐negative bacterial cell walls may act as polyelectrolytes, effectively reducing the critical micellization concentration (CMC) of positively charged peptides and lipopeptides. This reduction is expected to facilitate their aggregation, potentially enhancing their accumulation at the bacterial membrane and increasing their effectiveness in disrupting membrane integrity and exerting antimicrobial activity. Therefore, understanding the interplay between EDL effects, polyelectrolytic properties of bacterial cell walls, and the behavior of antimicrobial peptides is essential for elucidating their mechanisms of action and optimizing their therapeutic potential.
Quality of systematic reviews and meta‐analyses in dermatology
Authors: Muthiah Annapoorani , Lee Loch Kith , Koh John , Liu Ashly , Tan Aidan 
Published: May 2024

AbstractIntroductionAlthough the number of published systematic reviews and meta‐analyses in dermatology has increased over the past decade, their quality is unknown.ObjectiveThe objective of this study was to determine the change in risk of bias, methodological quality and reporting quality of systematic reviews and meta‐analyses in dermatology between 2010 and 2019.MethodsWe conducted a comparative study of systematic reviews and meta‐analyses published in the 10 highest‐ranked dermatology journals in 2010 and 2019. Studies were identified through electronic searches of MEDLINE, Embase, and eight other bibliographic databases. Risk of bias and methodological quality were assessed in duplicate with the risk of bias in systematic reviews (ROBIS) and A MeaSurement Tool to Assess systematic Reviews‐2 (AMSTAR‐2) tools, respectively, with the latter only applied to studies of interventions. Reporting quality was assessed with the Preferred Reporting Items of systematic reviews and Meta‐Analyses (PRISMA) 2009 and PRISMA for abstracts (PRISMA‐A) 2013 statements.ResultsWe included 27 systematic reviews and meta‐analyses published in 2010 and 127 published in 2019. There was no evidence of a difference in the proportion of systematic reviews and meta‐analyses at high/unclear risk of bias with ROBIS (Fisher's exact test = 1.00) or critically low methodological quality using AMSTAR‐2 (Fisher's exact test = 0.456), between 2010 and 2019. There was evidence of a difference in proportion of PRISMA (t(26) = 2.7, p = 0.01), and very strong evidence of a difference in proportion of PRISMA‐A (t(26) = 4.2, p < 0.001) checklist items adequately reported between 2010 and 2019. The difference in mean proportion of PRISMA checklist items adequately reported was 3.6 items more (95% confidence interval [CI]: 1.8–5.4 items more) in 2019 (mean = 10.7 items, SD = 2.4 items) than in 2010 (mean = 7.1 items, SD = 2.9 items), and of PRISMA‐A checklist items adequately reported was 1.1 items more (95% CI: 0.2–2.0 items more) in 2019 (mean = 5.6 items, SD = 1.5 items) than in 2010 (mean = 4.4 items, SD = 1.7 items)ConclusionsNo improvement was observed in the overall methodological quality of included systematic reviews and meta‐analyses; however, there was strong evidence of improvement in the overall reporting quality.
RuPHOX‐Ru Catalyzed Asymmetric Cascade Hydrogenation of 3‐Substituted Chromones for the Synthesis of Corresponding Chiral Chromanols
Authors: Xu Shaofeng , Xu Wenqi , Dong Siqi , Liu Delong , Zhang Wanbin 
Published: May 2024

AbstractAn efficient RuPHOX−Ru catalyzed asymmetric cascade hydrogenation of 3‐substituted chromones has been achieved under mild reaction conditions, affording the corresponding chiral 3‐substituted chromanols in high yields with excellent enantio‐ and diastereoselectivities (up to 99 % yield, >99 % ee and >20 : 1 dr). Control reactions and deuterium labelling experiments revealed that a dynamic kinetic resolution process occurs during the subsequent hydrogenation of the C=O double bond, which is responsible for the high performance of the asymmetric cascade hydrogenation. The resulting products allow for several transformations and it was shown that the protocol provides a practical and alternative strategy for the synthesis of chiral 3‐substituted chromanols and their derivatives.
A Simplified Approach for Calculating Heat Transfer Coefficients for Fluid Guiding Elements with Alternating Redirections of Flow
Authors: Biffar Linus , Benzinger Walther , Pfeifer Peter 
Published: May 2024

AbstractFluid guiding elements (FGEs), additive manufactured inserts that enhance heat transfer, have shown the potential to reduce the size of pipe‐in‐pipe heat exchangers up to a factor of 20. Due to their unique design, the calculation of the geometrical parameters for a specific application remains challenging and was initially solved by computationally expensive computational fluid dynamics simulations. This work presents a simplified approach, which treats the fluid and the FGE as pseudo‐homogeneous to enable the fast calculation of effective heat transfer coefficients. The approach is developed based on water in laminar flow state and subsequently tested with different fluids.
Millistructured Coiled Flow Inverter for Biphasic Continuous Flow 5‐Chloromethylfurfural Synthesis
Authors: Schael Frank , Steup Benjamin , Rojahn Patrick , Nigam Krishna D. P. 
Published: May 2024

AbstractSyntheses of alternative platform chemicals, such as 5‐chloromethylfurfural (CMF), from bio‐based starting materials are often associated with complicated kinetic schemes and mass transfer processes. Millistructured flow reactor concepts can help to elucidate kinetic schemes and determine rate constants which are of crucial importance for the design of respective technical processes. For the first time, the influence of proton concentration on the rate constants involved in the biphasic synthesis of CMF is systematically investigated. Results are discussed in terms of green chemistry metrics.
Assessment of air quality benefits of vegetation in an urban‐industrial region of India by integrating air monitoring with i‐Tree Eco model
Authors: Vashist Mallika , Kumar Thangamani Vijaya , Singh Santosh Kumar 
Published: May 2024

AbstractIn the last few years, urban trees have emerged as an effective nature‐based solution to mitigate increasing air pollutant levels due to urbanization and industrialization. This study aims to assess the synergistic effect of urban trees on improving air quality by combining real‐time PM2.5 monitoring with the i‐Tree Eco model. The monitoring was conducted during rush hours with high traffic volume and during non‐rush hours, in both the tree alley and a non‐tree road section within the industrial areas of the north‐west region of the National Capital Territory of Delhi, India. The i‐Tree Eco model was run using the diameter at breast height values of tree species present in the study area, and the PM2.5 reduction ability of the trees was quantified. The results from both approaches indicated that urban trees can significantly reduce the traffic‐fed PM2.5 concentrations. Therefore, it is suggested that tree plantations be integrated into air pollution management strategies in urbanized regions with high traffic volumes. Although this study explores the initial link between trees and air quality in Delhi, further research incorporating local wind speed and direction measurements would provide a more comprehensive understanding of how trees influence air quality in any highly polluted urban setting.
The Promising Potential of Gallium Based Liquid Metals for Energy Storage
Authors: Rehman Waheed Ur , Manj Rana Zafar Abbas , Ma Yuanyuan , Yang Jianping 
Published: May 2024

AbstractEnergy storage devices play a crucial role in various applications, such as powering electronics, power backup for homes and businesses, and support for the integration of renewable energy sources into electrical grid applications. Electrode materials for energy storage devices are preferred to have a flexible nature, conductive, better capacity, and low‐toxicity. Using Gallium based liquid metal alloys, such as Eutectic Gallium‐Indium (EGaIn), Eutectic Gallium‐Tin (EGaSn), and Eutectic Gallium‐Indium‐Tin (EGaInSn), as electrode materials play very important role in energy storage devices. These liquid metals have some interesting properties with a self‐healing nature, high mechanical stability, compatibility with various materials, fluidity, low young's modulus, high electrical and thermal conductivity. Those properties have made it suitable to be used in various energy storage devices. In this mini review, we have concisely described the advantages and challenges of using liquid metal as electrode materials for various energy storage devices.
A conceptual model of artificial intelligence effects on circular economy actions
Authors: Tutore Ilaria , Parmentola Adele , di Fiore Michele Costagliola , Calza Francesco 
Published: May 2024

AbstractThe circular economy (CE) presents a contemporary approach to integrating economic activity and environmental well‐being sustainably, opposing the linear open‐ended system. However, implementing this paradigm poses challenges, needing a fundamental shift in companies' strategies and business models. Emerging technology can support companies in transition toward CE and in particular artificial intelligence (AI) can play a crucial role in facilitating this transition by supporting companies not only in specific CE activities but also in strategically redefining their entire business models. Recognizing the increasing importance of both AI and CE in management literature, our paper seeks to integrate these two distinct streams of literature. Starting from existing studies, it tries to provide a framework able to understand the role of AI technology into enhancing CE. Through a systematic literature review using the Preferred Reporting Items for Systematic Review and Meta‐Analysis protocol, using keywords research on three databases, we identified 63 articles that concurrently address both CE and AI topics. Subsequent co‐occurrence and content analyses revealed how AI is utilized to bolster CE efforts leveraging the ReSOLVE framework (from the acronymous of Regenerate, Share, Optimise, Loop, Virtualise, and Exchange)—an operational tool for CE. The last step consists into the development of a conceptual framework outlining four stages of AI's engagement with the CE: namely System optimization, System redesign, Business Model redesign, and Ecosystem innovation. From our study emerges that while AI is already recognized for enhancing specific activities within CE, its potential as a strategic planning tool for business model redesign and ecosystem innovation remains largely unexplored.