bluuebunny/crossref_metadata_2025_split huggingface dataset:
Developmental and epileptic encephalopathies in children: clinical, neurophysiological, neuroimaging and genetic characteristics
Authors: Kyrylova L.H. , Miroshnykov O.O. , Yuzva O.O. , Badiuk V.M. , Dolenko O.O. , Bondarenko Yu.M. 
Published: May 2024

Background. The purpose of the study to analyze the clinical, neurophysiological, neuroimaging and genetic characteristics of young children with developmental and epileptic encephalopathy and to determine risk predictors for the development of autism spectrum disorders, with the aim of forming a cohort of children in need of dynamic monitoring and early intervention. Materials and methods. Thirty-eight children aged 0–3 years with developmental and epileptic encephalopathy were included in the study. The examination included assessment of neurological status, history taking, assessment of semiology and determination of seizure type, assessment of development and screening for autism spectrum disorders at the age of 18 and 24 months, video-EEG monitoring during night sleep, magnetic resonance imaging of the brain, screening for pathogenic variants by whole exome sequen-cing. Results. A feature of this group of disorders is the presence of subtle, often unrecognized epileptic seizures, which are manifested by persistent focal (60.5 %) or generalized (31.6 %) activity with medium (55.3 %) or high (15.8 %) index of spike-and-wave activity during the stage of slow sleep and the amplitude emphasis over the frontal (52.6 %) or temporal (28.9 %) lobes. According to magnetic resonance imaging, structural changes in the brain were found in 91.1 % of children, including focal or diffuse changes in the white matter of the brain in 36.8 %, hypoplasia of the corpus callosum in 21.1 %, atrophic changes in the cerebral cortex in 15.8 %, congenital malformations in 13.2 % of cases. Pathogenic variants of 35 different genes were found in the examined children with the onset of seizures during the first year of life. Pathogenic variants of genes responsible for the synthesis and repair of DNA and RNA (28.9 %) and the activity of intracellular enzymes were the most common — 8 cases (21.1 %). The share of children with general developmental delay at the age of 24 months was 11.9 %, and cognitive impairment — 34.2 %. Conclusions. It was shown that children with a history of generalized tonic-clonic seizures (RR = 2.13) had a high risk of developing autism spectrum disorders at 24 months. A positive relationship was found between the presence of mutations in genes responsible for DNA synthesis and repair (RR = 1.88) and an increased risk of developing ASD at the age of 24 months (90.9 % of children).
Characteristics of fibrin/fibrinogen degradation products in multiple sclerosis following SARS-CoV-2 infection
Authors: Halenova T.I. , Raksha N.G. , Vovk T.B. , Karbovskyy V.L. , Sholomon S.M. , Melnyk V.S. , Savchuk O.M. 
Published: May 2024

Background. The purpose of this study was to investigate plasma levels of fibrinogen and products of its degradation in patients with multiple sclerosis (MS) with and without a history of coronavirus disease 2019 (COVID-19). Materials and methods. We examined 97 patients with MS. Based on the presence of COVID-19, all cases were divided into two groups. MS group included 56 patients who did not suffer from COVID-19 previously. MS + COVID group consisted of 41 cases who had a laboratory-verified diagnosis of COVID-19. The group of healthy controls included 30 healthy volunteers. Spectrophotometric techniques were used to measure the concentrations of fibrinogen, D-dimer, and soluble fibrin monomer complexes (SFMCs). Size-exclusion chromatography was applied to analyze the composition of SFMC fractions. Results. We found that concentrations of fibrinogen, D-dimer, and SFMCs were remarkably increased in plasma of all MS patients compared with healthy controls. The levels of D-dimer, and SFMCs did not differ between two MS groups, while plasma fibrinogen concentration was significantly increased in MS + COVID patients compared to MS group. Moreover, the development of MS was accompanied by the changes in both quantity and quality of SFMC composition compared to that of healthy controls. Our results demonstrated accumulation of high-molecular-weight SFMCs in plasma of MS patients. Conclusions. The findings indicated that MS patients had changed hemostasis characteristics; however, more research is required to determine the connection between particular hemostatic factors, namely fibrinogen, D-dimer, and SFMCs, and the pathophysiology of MS.
Calcium-carbonate and phytoelements to improve egg production in backyard laying hens under heat stress
Authors: Gutiérrez Lilia , Mendoza Corazón de Jesus , Sánchez Zacnité , Carrillo Lizbeth , Sumano López Héctor 
Published: May 2024

The bioavailability (F) of calcium and other nutrients from the gastrointestinal tract in the second and third laying cycle hens and in hens under heat-stress is insufficient to sustain the necessary egg production. The administration of additional amounts of any source of calcium has been shown to be insufficient to meet the demand for calcium. However, improved calcium F has already been achieved in these hens if calcium carbonate is pharmaceutically prepared as patented pellets (FOLAs). Hence, clinical challenges were set to test the FOLA pellets as a form to sustain egg production and eggshell thickness in 180-second and 180-third cycle Bovans-White laying hens, randomly divided into six groups, as follows: cycle-2 control group (GCC2); FOLA-group-capsaicin (GFcC2); FOLA-group-capsaicin-turmeric powder-cinnamon powder (GfexC2); control-group for third cycle hens (GCC3); FOLA-group-capsaicin (GFcC3); FOLA-group-capsaicin-turmeric powder-cinnamon powder (GFexC3). This trial was carried out under moderate heat-stress conditions, and a follow-up was carried out utilizing eye thermographic measurements. The results show that all FOLA-fed hens of the second or third laying cycle presented better laying average and eggshell thickness than the untreated control groups, i.e., GFcC2 128 % higher than GCC2; GfexC2 135 % higher than GCC2; GFcC3 168 % higher than GCC3; and GFexC3 was 173 % higher than GCC3 (P < 0.01 in all comparisons). FOLA pellet formulation, similar to GfexC2, is postulated as a viable natural solution to counter the decreased egg-laying and shell thickness in second and third-cycle hens under moderate heat stress.
Desenvolvimento de ferramenta de monitoramento para planos municipais de gestão integrada de resíduos sólidos
Authors: Piovezan Andressa Aparecida , Campani Darci Barnech , Tubino Rejane Maria Candiota 
Published: May 2024

O objetivo da pesquisa foi elaborar uma metodologia de monitoramento para Planos Municipais de Gestão Integrada de Resíduos (PMGIRS) através de macrodiretrizes. O PMGIRS do município de Novo Hamburgo–RS, foi avaliado e de acordo com a temática, as ações dos projetos foram aglutinadas em macrodiretrizes. Foi elaborado um método de coleta de dados das ações dos projetos existentes no PMGIRS, por níveis gradativos da situação atual, adaptou-se as metas estipuladas para o ano de monitoramento e pesos para as ações foram definidos através da técnica de Escala Likert. O PMGIRS do município de Novo Hamburgo possui 4 grandes programas para o monitoramento do plano, ao total são 31 ações, diagnosticadas em níveis de 1 a 5 em relação a seu grau de atingimento de metas. As ações do Programa para Resíduos Sólidos Urbanos (PRSU) atingiram 50% de suas metas, enquanto o Programa Para Resíduos Sólidos Não Urbanos (PRSNU) 37.5%, o Programa para a Educação Ambiental (PEA) 60% e o Programa para a Melhoria de Gestão (PMG) 16.6%. Posteriormente, as ações dos programas foram subdivididas em 8 macrodiretrizes, onde 1 foi considerada satisfatória. O indicador da meta atingida da Macrodiretriz 1 (M1): tecnologias e Gestão Adequadas a Serviços de Limpeza Urbana e Manejo de Resíduos Sólidos) atingiu a pontuação de 7.80, enquanto sua meta estipulada para o ano de monitoramento era de 9.55; M2: minimização da geração de resíduos sólidos) 13.20 de 16.33; M3: valorização de resíduos 8.33 de 10.89; M4: universalização e integralidade 15.75 de 17.00; M5: controle social 15.75 de 19.00; M6: articulação com políticas públicas 11.00 de 13.43; M7: educação para sustentabilidade 16.85 de 15.85 e M8: Sustentabilidade 10.26 de 28,45. Considera-se a ferramenta inovadora e que servirá de auxílio e direcionamento para órgãos, empresas e municípios que elaborarem seus planos com a metodologia de monitoramento por macrodiretrizes.
Impactos da polifarmácia na saúde bucal de idosos: uma revisão de escopo
Authors: Duarte Farias Gabrieli , Pimenta Vanderlei Paulo Rennan , Gomes de Santana Ilan Hudson , Batista Mélo Cláudia , Silvia Laureano Dalle Piagge Carmem 
Published: May 2024

Esse artigo tem como objetivo analisar na literatura os principais impactos da polifarmácia na saúde bucal da pessoa idosa. Trata-se de uma revisão de escopo, cuja busca foi realizada nas seguintes bases de dados: LILACS, PubMed, Scopus, Web of Science e Google Scholar como literatura cinzenta, sem restrição temporal. As buscas foram realizadas utilizando descritores combinados por meio dos operadores boleanos AND e OR: (“aged” OR “elderly” OR “elderlies” OR “health of the elderly”) AND (“oral manifestations” OR “oral manifestation” OR “oral health” OR “pathology, oral”) AND (“polypharmacy” OR “polymedication”). O protocolo desta revisão foi registrado na Open Science Framework, seguindo as recomendações do Manual do Instituto Joanna Briggs – JBI Manual for Evidence Synthesis. Foram encontrados 262 estudos e após a remoção dos duplicados restaram 81 artigos; em seguida foi feita a exclusão por meio do título e resumo, e depois pela leitura na íntegra, selecionando-se 5 estudos para compor a amostra final. A alteração prevalente foi a Xerostomia, sendo apresentada em 100% dos estudos selecionados. Quanto aos sinais e sintomas, observou-se boca seca, má higiene oral, presença de cárie e dificuldade em ingerir alimentos, o que algumas vezes culminou em má nutrição. Houve impacto direto da xerostomia na qualidade de vida da população idosa, tanto em relação à nutrição quanto ao comprometimento da saúde bucal.
Enamel remineralisation prospect of Moringa Oleifera hydrogel, eggshell hydrogel versus sodium fluoride varnish on artificially demineralised primary teeth: in vitro study
Authors: Essam Eliwa Mona , Mohamed Yousra , Hossam Ehsan 
Published: May 2024

Purpose: The purpose of the present in vitro study is to investigate and compare the remineralising potential of Moringa Oleifera extract, eggshell, and sodium fluoride varnish on microhardness of artificially demineralised enamel of primary teeth with biomimetic minimally invasive approach following the world paradigm shift towards natural products in paediatric dentistry.
Material and methods: Sample size included 44 primary molars. The mineral content and surface microhardness of all specimens were initially assessed using energy dispersive x-ray examination (EDX) and Vickers microhardness. The specimens were artificially demineralised for 96 h at a temperature of 37°C and then reassessed directly after demineralisation. The demineralised enamel specimens were randomly divided into four groups according to the remineralisation regimen utilised. Group 1: Artificial saliva (control); Group 2: Sodium fluoride varnish; Group 3: Eggshell hydrogel; and Group 4: Moringa Oleifera hydrogel. The specimens were stored for 8 days and then subsequently evaluated using EDX and microhardness assessment by Vickers microhardness test and scanning electron microscope (SEM).
Results: Regarding the microhardness test, there was a significant difference between the Moringa Oleifera group and Eggshell group compared to fluoride varnish (p < 0.05). Regarding EDX analysis, there was a statistically significant difference (p < 0.05) between Moringa Oleifera group and Eggshell group compared to fluoride varnish as the highest values were for Moringa Oleifera and Eggshell. On the other hand, there was no statistically significant difference (p > 0.05) between Moringa Oleifera and Eggshell in both the measurements.
Conclusion: Moringa Oleifera and Eggshell might be considered as a biomimetic natural material capable of guiding enamel tissue remineralisation in early carious lesion of primary teeth.
Clinical relevance: This research demonstrated the capability for early enamel caries to be remineralised using novel materials with a naturally counterpart implicated in biomineralisation as proved to be more effective than traditionally used fluoride varnish in primary teeth.
Dossiê Ensinos Transgressivos, Aprendizagens Solidárias
Authors: Aguiar André Effgen , Oliveira Grassinete C. de Albuquerque , Queiroz Amilton José Freire de , Righi Fernanda , Lomeli Jafte Dilean Robles 
Published: May 2024

No início de fevereiro de 2024 lançamos o volume 45, n. 1 (2024), do Dossiê Temático I Congresso Internacional do ELLAE: Ensinos Transgressivos, Aprendizagens Solidárias – Por uma Ecologia de Línguas-Literaturas-e-Linguagens com Freire (1995) nos orientando ser necessário recomeçar sempre. Abrimos este segundo volume retomando Freire em diálogo com Fanon. O primeiro ao argumentar que, enquanto presença na História e no mundo, esperançar por uma pedagogia crítica não é em vão. O segundo, por nos mostrar que o problema não é conhecer o mundo em que vivemos, mas transformá-lo. Esse lutar, esperançar, sonhar e transformar os contextos em que os autores deste volume se encontram situados faz parte de uma educação crítica e libertadora.
Development of e-Modules Problem Base Learning with the Help of App Mit Invetor to Increase Students' Interest in Learning
Authors: Azizah Nunung , Sukmadewi Angela Gusti ayu , Jumadi Jumadi 
Published: May 2024

Interest in learning is crucial in the learning process. With an interest in learning, it will also be able to affect their academic abilities, and this will be one of the supporters of the success of the learning process. Judging from the importance of the function of interest in learning, the purpose of this research is to develop electronic learning media to increase students' interest in learning. The object of this research, is the students of class X MIPA 2 and X MIPA 4 SMA 1 Kalasan with a total of 70 people. This research is development research with ADDIE design. The data collection method in this study used a questionnaire method with a Likert scale. Based on the analysis, the questionnaire obtained by X MIPA 2 is 84.5% and X MIPA 4 is 86.5%. Based on this data, the questionnaire can be said to be valid, so it is feasible to use it to increase student interest in learning. Keywords: interest in learning; electronic learning
LEARNING IN THE COVID-19 PANDEMIC
Authors: Safaringga Helen 
Published: May 2024

The Covid-19 pandemic resulted in a remarkable change in learning activities, where all levels of education had to be transformed in order to adapt to learning from home through online media. This study aims to find out how to learn on the Covid-19 pandemic for students, schools, and people. This research was conducted with literature research. The source of research data is obtained from articles and publication journals collected using documentation techniques. Analysis techniques using content analysis of literature and articles that are the source of research data. The results showed that in the practice of implementing online learning, many obstacles occurred both from students, teachers, and parents. These constraints make online learning less effective Keywords: Pandemic; Covid-19; learning; online
THE EFFECT OF A JIGSAW-TYPE COOPERATIVE LEARNING MODEL BASED ON BLENDED LEARNING USING GOOGLE CLASSROOM HAS AN IMPACT ON STUDENT LEARNING OUTCOMES ON VECTOR MATERIAL
Authors: Sipahutar Nur Halimah 
Published: May 2024

This study aims to determine the effect of the jigsaw cooperative learning model based on blended learning by utilizing google classroom on student learning outcomes in vector material. This study used a quasi-experimental type of research. The data collection method used was test instruments (pretest and posttest) which were distributed to two classes, namely class X Mipa 3 as the control class and class X Mipa 2 as the experimental class. The test instrument used was 15 questions in the form of multiple choice which had been tested for validity, discriminatory power, level of difficulty, and reliability. The population in this study were all students of class X MAN 2 North Labuhanbatu as many as 6 classes. The average number of students in each class is 36 people. Two classes of samples were selected using simple random sampling technique. Based on the results of the calculation of the hypothesis test using the one-party t test at a significance level of 5% and dk = 36, a tcount value of 3.27 is obtained and a ttable value is 1.99 or tcount > ttable, so that it can be stated that Ha is accepted and H0 is rejected. So it can be concluded that the application of the jigsaw type cooperative learning model based on blended learning by utilizing google classroom has an effect on student learning outcomes in vector material.
IN SILICO STUDY OF Hibiscus Sabdariffa Linn. ACTIVE COMPOUNDS IN GLP-1R: POTENTIAL AS ANTIDIABETIC DRUG
Authors: Andriani T. , Mawaddah N. , Erlina L. , Anggraeni R. K. , Ibrahim N. , Siagian M. 
Published: May 2024

Diabetes mellitus is a metabolic disorder characterized by hyperglycemia due to reduced insulin production and/or insulin resistance. GLP-1 can increase insulin secretion, improve insulin sensitivity, and lower the blood glucose levels by binding to the GLP-1 receptor (GLP-1R). Several plants have been used as antidiabetic drugs. This study aims to see the interactions of the active compounds in Hibiscus sabdariffa Linn. and GLP-1R in silico. The research started with internal validation of the receptor GLP-1 (6ORV), and then the native ligand was docked. The 6ORV receptor validation results have an RMSD value of 2.14Å. The results of docking scores of the 3 best active compounds Hibiscus sabdariffa Linn. are myricetin-3-arabinogalactoside (-10.64 kcal/mol), tetra-O-methyljeediflavanone (-9.95 kcal/mol), and ethyl chlorogenate acid (-7.73 kcal/mol). The amino acids that contribute to the affinity at the active site of the ligand bond with the receptor are Trp 297, Trp 203, Met 204, Phe 230, Try 220, Lys 197. These findings indicate that the active compound Hibiscus sabdariffa Linn. can bind directly to GLP-1R.
Keywords: Diabetes mellitus, Hibiscus sabdariffa Linn., GLP-1R
ABSTRAK
Diabetes melitus merupakan gangguan metabolisme yang ditandai dengan kondisi hiperglikemia akibat produksi insulin yang berkurang dan atau kondisi resistensi insulin. GLP-1 dapat meningkatkan sekresi, sensitivitas insulin, dan menurunkan kadar glukosa darah dengan cara mengikat reseptor GLP-1 (GLP-1R). Beberapa tanaman telah digunakan sebagai obat antidiabetes. Penelitian ini bertujuan untuk melihat bagaimana interaksi senyawa aktif dalam Hibiscus sabdariffa Linn. terhadap GLP-1R secara in silico. Penelitian dimulai dengan melakukan validasi internal reseptor GLP-1 (6ORV) kemudian dilakukan proses docking terhadap native ligand. Hasil validasi reseptor 6ORV mempunyai nilai RMSD 2.14Å. Hasil score docking 3 senyawa aktif Hibiscus sabdariffa Linn. terbaik adalah myricetin-3-arabinogalactoside (-10,64 kcal/mol), tetra-O-methyljeediflavanone (-9,95 kcal/mol), dan ethyl chlorogenate acid (-7,73 kcal/mol). Asam amino yang berperan terhadap afinitas pada sisi aktif ikatan ligan dengan reseptor adalah Trp 297, Trp 203, Met 204, Phe 230, Try 220, Lys 197. Temuan ini menunjukkan bahwa senyawa aktif Hibiscus sabdariffa Linn. dapat berikatan langsung dengan GLP-1R.
Kata kunci: Diabetes melitus, Hibiscus sabdariffa Linn., GLP-1R
Authors: Tea M. T. D. , Adu R. E. Y. , Moruk L. D. 
Published: May 2024

Pewarnaan kain tenun Timor menggunakan pewarna alami menghasilkan warna kain yang kurang intens dan kurang stabil terhadap pencucian, sehingga membutuhkan proses mordanting menggunakan biomordan tannin dari kulit biji asam (Tamarindus indica L.). Beberapa faktor dapat mempengaruhi proses mordanting untuk memperoleh karakteristik warna kain yang tidak mudah luntur terhadap pencucian yaitu konsentrasi mordan, lama waktu, suhu dan teknik mordanting yang digunakan. Pada penelitian ini dilakukan optimalisasi terhadap proses mordanting pada pewarnaan kain tenun Timor untuk mengetahui kondisi optimum dalam pewarnaan dengan mordan tanin dari kulit biji asam. Ekstraksi zat warna dan biomordan tanin dilakukan terlebih dahulu. Optimalisasi dilakukan terhadap teknik mordanting seperti pra, meta dan pasca mordanting. Variabel lain yang dioptimasi yaitu konsentrasi biomordan, suhu dan lama waktu mordanting. Parameter kualitas kain yang ditentukan setelah proses pewarnaan adalah ketahanan luntur terhadap pencucian yang diuji menggunakan Staining Scale Standard. Hasil penelitian menunjukkan bahwa karakteristik ketahanan luntur kain tenun Timor yang diperoleh melalui pewarnaan secara alami menggunakan biomordan tanin kulit biji asam dipengaruhi oleh kondisi mordanting. Ketahanan luntur yang baik diperoleh pada penggunaan teknik pra-mordanting, konsentrasi biomordan 15%, waktu 120 menit dan suhu 95oC.
Kata kunci: biomordan, kulit biji asam, tanin, tenun Timor, warna alami
ABSTRACT
The natural dyeing of Timor woven fabrics produces products with less color intensity and less stability to washing, so it requires a mordanting process using bio-mordant tannin from tamarind seed coat (Tamarindus indica L.). Several factors can affect the mordanting process to obtain the characteristics of high color fastness of fabrics namely the mordant concentration, length of time, temperature and mordanting technique. In this study, optimization of the mordanting process for dyeing Timor woven fabrics was carried out to determine the optimum conditions for staining with tannin mordant from the tamarind seed coat. The extraction of dyestuffs and tannin bio-mordant was carried out first. Optimization is carried out on mordanting techniques such as pre, meta, and post-mordanting. Other variables that were optimized were concentration of bio-mordant, temperature, and length of mordanting time. The parameter of the fabric quality after the dyeing process is the color fastness to washing which is tested using the Staining Scale Standard. The results showed that the fastness characteristics of Timor woven fabrics obtained through natural dyeing using tamarind seed coat tannin bio-mordant were affected by mordanting conditions. A good color fastness was achieved by using the pre-mordanting technique, 15% bio-mordant concentration, 120 minutes, and 95oC temperature.
Keywords: bio-mordant, tamarind seed coat, tannin, Timor weaving, natural color