bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does self-regulation and autonomic regulation have an influence on survival in breast and colon carcinoma patients? results of a prospective outcome study
Authors: Kröz Matthias , Reif Marcus , Büssing Arndt , Zerm Roland , Feder Gene , Bockelbrink Angelina , von Laue Hans Broder , Matthes H Harald , Willich Stefan N , Girke Matthias 
Published: September 2011

Abstract

Background
Cancer Related Fatigue (CRF) and circadian rhythm have a great impact on the quality of life (HRQL) of patients with breast (BC) and colon cancer (CRC). Other patient related outcomes in oncology are measured by new instruments focusing on adaptive characteristics such as sense of coherence or self-regulation, which could be more appropriate as a prognostic tool than classical HRQL. The aim of this study was to assess the association of autonomic regulation (aR) and self-regulation (SR) with survival.

Methods
146 cancer patients and 120 healthy controls took part in an initial evaluation in 2000/2001. At a median follow up of 5.9 years later, 62 of 95 BC, 17 of 51 CRC patients, and 85 of 117 healthy controls took part in the follow-up study. 41 participants had died. For the follow-up evaluation, participants were requested to complete the standardized aR and SR questionnaires.

Results
On average, cancer patients had survived for 10.1 years with the disease. Using a Cox proportional hazard regression with stepwise variables such as age, diagnosis group, Charlson co-morbidity index, body mass index (BMI)) aR and SR. SR were identified as independent parameters with potential prognostic relevance on survival While aR did not significantly influence survival, SR showed a positive and independent impact on survival (OR = 0.589; 95%-CI: 0.354 - 0.979). This positive effect persisted significantly in the sensitivity analysis of the subgroup of tumour patients and in the subscale 'Achieve satisfaction and well-being' and by tendency in the UICC stages nested for the different diagnoses groups.

Conclusions
Self-regulation might be an independent prognostic factor for the survival of breast and colon carcinoma patients and merits further prospective studies.
Preclinical multimodality phantom design for quality assurance of tumor size measurement
Authors: Lee Yongsook C , Fullerton Gary D , Baiu Cristel , Lescrenier Margaret G , Goins Beth A 
Published: September 2011

Abstract

Background
Evaluation of changes in tumor size from images acquired by ultrasound (US), computed tomography (CT) or magnetic resonance imaging (MRI) is a common measure of cancer chemotherapy efficacy. Tumor size measurement based on either the World Health Organization (WHO) criteria or the Response Evaluation Criteria in Solid Tumors (RECIST) is the only imaging biomarker for anti-cancer drug testing presently approved by the United States Food and Drug Administration (FDA). The aim of this paper was to design and test a quality assurance phantom with the capability of monitoring tumor size changes with multiple preclinical imaging scanners (US, CT and MRI) in order to facilitate preclinical anti-cancer drug testing.

Methods
Three phantoms (Gammex/UTHSCSA Mark 1, Gammex/UTHSCSA Mark 2 and UTHSCSA multimodality tumor measurement phantom) containing tumor-simulating test objects were designed and constructed. All three phantoms were scanned in US, CT and MRI devices. The size of test objects in the phantoms was measured from the US, CT and MRI images. RECIST, WHO and volume analyses were performed.

Results
The smaller phantom size, simplified design and better test object CT contrast of the UTHSCSA multimodality tumor measurement phantom allowed scanning of the phantom in preclinical US, CT and MRI scanners compared with only limited preclinical scanning capability of Mark 1 and Mark 2 phantoms. For all imaging modalities, RECIST and WHO errors were reduced for UTHSCSA multimodality tumor measurement phantom (≤1.69 ± 0.33%) compared with both Mark 1 (≤ -7.56 ± 6.52%) and Mark 2 (≤ 5.66 ± 1.41%) phantoms. For the UTHSCSA multimodality tumor measurement phantom, measured tumor volumes were highly correlated with NIST traceable design volumes for US (R2 = 1.000, p < 0.0001), CT (R2 = 0.9999, p < 0.0001) and MRI (R2 = 0.9998, p < 0.0001).

Conclusions
The UTHSCSA multimodality tumor measurement phantom described in this study can potentially be a useful quality assurance tool for verifying radiologic assessment of tumor size change during preclinical anti-cancer therapy testing with multiple imaging modalities.
Synthesis, X-ray crystal structure and theoretical study of 4-ethyl-5-(2-thienyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione; structural comparison with its aromatic analogs
Authors: Wawrzycka-Gorczyca Irena , Siwek Agata 
Published: September 2011

Abstract
The crystal structure of 4-ethyl-5-(2-thienyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione (1) was determinäed. The compound crystallizes in the monoclinic space group P21/n (Z = 4) with a = 8.679(2), b = 7.873(2), c = 14.657(3) Å, β = 105.56(3)° and V = 964.8(4) Å3. Its molecular and crystal structure was compared with three aromatic analogs. In three crystal structures of 2,4-dihydro-3H-1,2,4-triazole-3-thione derivatives, Ntriazole—H · · · S(=C) dimer as the main structural motif is formed, while in one Ntriazole—H · · · S hydrogen bonds connect molecules to make helix arrangement. Moreover, in 1, Cethyl—H · · · S(=C), Sthione · · · Sthiophene and πthiophene · · · πtriazole interactions are observed; there are not N—H · · · N hydrogen bonds.
NMR in DMSO and IR experiments confirmed the compound to exist as the thione tautomer.
We carried out extensive conformational searches for 1 at the molecular mechanics level in order to compare structures obtained from different force fields with the experimental results.
On the modelling of the powder pattern from a nanocrystalline material
Authors: Scardi Paolo , Leoni Matteo , Beyerlein Kenneth Roy 
Published: September 2011

Abstract
Some issues related to the modelling of the powder diffraction pattern of a nanocrystalline material are proposed. Serious misunderstanding of the results can occur when the peak profiles are not correctly considered in reciprocal space, or when the subtle details of the peak shape due to the peculiar microstructure of the material are not taken into account.
Current evidence for recommendation of surgery, medical treatment and vitamin D repletion in mild primary hyperparathyroidism
Authors: Bollerslev Jens , Marcocci Claudio , Sosa Manuel , Nordenström Jörgen , Bouillon Roger , Mosekilde Leif 
Published: September 2011

Management of patients with mild primary hyperparathyroidism (PHPT) has been widely discussed because most patients today do not have specific symptoms. While surgery is always an option, the recommendations for treatment have shifted, which mostly reflects changes in clinical practice. In this study, we aimed to evaluate evidence for the current recommendations concerning operation vs observation, repletion with vitamin D (VitD) and alternative medical management.Surgery is followed by normalisation of calcium and parathyroid hormone (PTH) and a decrease in bone turnover followed by an increase in bone mass. It is not known what the consequences would be for the frequency of fractures. Randomised studies have indicated beneficial effects of operation on quality of life (QoL), but the effects have been minor and inconsistent. Operation seems not to be superior to observation for cardiovascular risk factors. Although PHPT patients in average have slightly decreased plasma 25OH VitD, severe symptomatic VitD deficiency seems not to be a characteristic of PHPT patients in Europe. However, if present, we recommend VitD substitution before final decision on surgical treatment. It is unknown whether routine VitD supplementation should be offered preoperatively to all patients with mild PHPT or as part of long-term medical treatment.Targeted medical management could be an option for patients with contraindications to surgery. Antiresorptive therapy might be appropriate for patients with a low bone mass to prevent further bone loss. Calcimimetics could be tried to control serum calcium levels although there is no evidence of an effect on the hypercalcaemic symptoms or the QoL. Combined therapy with calcimimetics and alendronate could be considered for patients with hypercalcaemia and overt bone disease.
Interaction between heavy smoking and CYP2A6 genotypes on type 2 diabetes and its possible pathways
Authors: Liu Tao , Chen Wei-Qing , David Sean P , Tyndale Rachel F , Wang Hui , Chen Yu-Ming , Yu Xue-Qing , Chen Wei , Zhou Qian , Ling Wen-Hua 
Published: September 2011

ObjectiveTo explore the interactions between smoking andCYP2A6genotypes on type 2 diabetes (T2DM) as well as potential pathways for smoking in causing T2DM.DesignCross-sectional study.MethodsA total of 1344 smokers with complete data from a community-based T2DM survey in Guangzhou and Zhuhai of China from July 2006 to June 2007 were interviewed with a structured questionnaire about socio-demographic status and daily cigarette consumption. Serum glucose, insulin, and cotinine were measured after an overnight fast. Subjects were genotyped forCYP2A6and classified, according to genotype, into normal, intermediate, slow, or poor nicotine metabolizers based on prior knowledge ofCYP2A6allele associations with nicotine C-oxidation rate. Abdominal obesity was defined as a waist-to-hip ratio ≥0.90 for males or ≥0.85 for females. Type 2 diabetic patients (n=154) were diagnosed according to WHO 1999 criteria. Chi-square tests, multivariate logistic regression models, and a structural equation model were used in this study.ResultsMultivariate analysis indicated that, compared with light smoking, heavy smoking significantly increased the risk of T2DM (odds ratio (OR)=1.75, 95% CI=1.01–3.05). There were significant interactions between heavy smoking and slowCYP2A6(OR=5.12, 95% CI=1.08–24.23) and poorCYP2A6metabolizer genotypes (OR=8.54, 95% CI=1.28–57.02) on T2DM. Structural equation modeling indicated thatCYP2A6moderation of smoking quantity risk on T2DM was mediated by the effects on serum cotinine, abdominal obesity, insulin resistance, and insulin secretion.ConclusionsHeavy smoking was significantly associated with T2DM, and this association was moderated byCYP2A6genotype and mediated by serum cotinine, abdominal obesity, insulin resistance, and insulin secretion.
The Impact of Class Size on Outcomes in Higher Education
Authors: Monks James , Schmidt Robert M. 
Published: September 2011

Abstract
Numerous studies have investigated the impact of class size on student outcomes. This analysis contributes to this discussion by isolating the impact of class size on student outcomes in higher education by utilizing a natural experiment at a selective institution which enables the estimation of class size effects conditional on the total number of students taught by a faculty member. We find that class size negatively impacts student assessments of courses and instructors. Large classes appear to prompt faculty to alter their courses in ways deleterious to students.
Information Sharing in Village Stability Operations: Field Experiences and Policy Considerations
Authors: Koziol Tyler M. , Wagenbrenner Chelsea , Wells Linton , Wilkinson Taylor 
Published: September 2011

AbstractThis paper describes a bottom‐up counterinsurgency strategy in Afghanistan known as Village Stability Operations, as well as some of the contributions information sharing strategies are making to its success. In a “population‐centric” strategy, it is essential to understand the people and what is important to them in their world, not ours. In this environment, information about the population, also known as “white” data, can be mission critical, although it wasn't treated as such at the beginning of the Afghan campaign. “White” information is not a panacea; it needs to be blended with enemy (“red”) information and government (“green”) information to form an integrated approach. The paper examines several projects that have been undertaken in Afghanistan, their successes and challenges, and how they have helped the Afghan population while supporting coalition objectives.
Single-incision laparoscopic transumbilical shunt placement
Authors: Tormenti Matthew J. , Adamo Matthew A. , Prince Jose M. , Kane Timothy D. , Spinks Theodore J. 
Published: September 2011

Ventriculoperitoneal (VP) shunt placement is the most common surgical treatment for hydrocephalus. Laparoscopic techniques to aid in the placement of the peritoneal portion have been reported previously. Laparoscopic shunt placement has been associated with decreased operating time, less blood loss, and shorter hospital stays. The authors describe a single-incision laparoscopic shunt (SILS) insertion technique that facilitates directed placement of the peritoneal portion of the catheter in children. A total of 6 pediatric patients underwent the SILS procedure between December 2008 and March 2009. This cohort included 5 girls and 1 boy; the average age was 6 years (range 1 day–16 years). One patient had previously undergone a VP shunt placement, but all other patients were undergoing the initial creation of their shunt. The most common pathological condition encountered was posttraumatic hydrocephalus (2 patients). All patients underwent successful placement of the peritoneal catheters. All catheters were seen to have CSF flowing freely within the peritoneal space.
The authors' recent experience shows that SILS placement is safe and feasible in children. It allows accurate, directed placement of the VP shunt with a single, almost invisible, umbilical incision. The shunt tubing is remote from this incision.
Guerre au Sahara-Sahel : la reconversion des savoirs nomades
Authors: Retaillé Denis , Walther Olivier 
Published: September 2011

Résumé Depuis le milieu des années 2000, le terrorisme a contribué à remettre les périphéries ouest-africaines au centre de l’actualité. Alors que les implications politiques et militaires de ces événements ont été largement discutées, une grande confusion règne sur les termes géographiques utilisés pour qualifier l’espace concerné. Terrorisme au Sahel, terrorisme au Sahara : où sont les bases ; où sont les terrains d’action ? Pis, la qualification « zonale » nuit à la compréhension de ce qui est au cœur de la capacité d’agir : des réseaux qui sont à la fois sociaux et spatiaux, passant à travers les limites qu’une géographie encore trop académique peine à transgresser faute d’avoir pleinement compris l’espace mobile des nomades.
Relationships between gregarine infection in damselflies, wetland type, and landscape characteristics
Authors: Mlynarek Julia J. , Bert Daniel G. , Peralta-Vázquez G. Haydeé , James Joanna A. , Forbes Mark R. 
Published: September 2011

AbstractAlthough human-modified landscapes are characterized by the loss of natural habitats, new habitats also can be created and exploited by many species. The importance of landscape change to invertebrate associations (particularly host-parasite associations) is understudied. Our objective was to determine whether prevalence and intensity of gregarine parasitism in the damselfly Ischnura verticalis (Say) (Odonata: Coenagrionidae) differed between 17 artificial and 7 natural wetlands in landscapes that varied in amount of forest and wetland cover and road density determined at spatial extents of 500m and 1km from each wetland. Wetlands were located in and around Ottawa, Ontario, and Gatineau, Quebec, Canada. Wetland type did not account for significant variation in principal components based on forest and wetland cover and road density at either spatial extent. Gregarine prevalence was higher in damselflies collected from natural wetlands than in those collected from artificial wetlands and was positively associated with increasing forest cover. In contrast, gregarine intensity was inversely related to road density. Our results suggest that parasitism of damselflies by gregarines is associated with wetland type and landscape characteristics, although the mechanisms producing such relationships are unknown.
Use of Porous Polyethylene Implants in Nasal Reconstruction
Authors: Choudhury Natasha , Marais Joe 
Published: September 2011

ABSTRACT

Introduction
Patients undergoing complex rhinoplasty, following previous trauma or cartilage deteriorating disease processes, present a surgical challenge. The availability of septal cartilage maybe limited, and alternative graft materials should be considered.

Methods
A retrospective study of our experience using the porous polyethylene (Medpor®) implant in nasal reconstruction was conducted. The indications for surgery are reviewed and the surgical outcomes noted. We also review the literature on available nasal implants and discuss their advantages and disadvantages.

Results
A total of 22 Medpor® nasal implants were used for augmentation rhinoplasty over a 6 and half years period. Three patients experienced a surgical complication, including one slipped dorsal implant, and two patients with graft extrusion. Both of these two patients had concomitant disease processes that would have resulted in a poor tissue microenvironment, which may have contributed to their graft failures.

Conclusion
In our experience, the Medpor® implant has proved very successful in patients requiring complex rhinoplasty, in a normal host tissue microenvironment.
Importance of Legal Expertise for Medical Practitioners in View of Increasing Complexities and Liabilities
Authors: Singh Avijit , Ahlawat Nishant 
Published: September 2011

ABSTRACT
A legal duty exists whenever a hospital or health care provider undertakes treatment to a patient. The duty is breached when the provider is failed to conform to the standard care. The breach of duty is a proximate cause of injury. Without damages there is no basis for a claim, regardless of whether the medical provider was negligent. Likewise, damage can occur without negligence, e.g., when someone dies from a fatal disease.
Intracranial and Orbital Complications of Sinusitis: A Case Series and Review of Literature
Authors: Shetty Kishore , Vaidyanathan Vinay 
Published: September 2011

ABSTRACT
Complications of paranasal sinus infection most often involve the orbit and periorbita. Because of widespread use of antibiotics, intracranial extension of paranasal sinusitis is rarely seen today. Nevertheless, the clinician must be aware of the potential of these complications, as late recognition of this condition and delay in treatment can increase morbidity and mortality rates. An interesting case series of sinusitis with orbital and intracranial complication is presented, which was radiologically evaluated, and was managed by endoscopic sinus surgery with drainage of subdural empyema by appropriate neurosurgical technique. The radiological tools played a very important role in both assessment and timing of surgical intervention. Unparallel role of radiological investigations cannot be overemphasized. The key to successful treatment is aggressive management and the timing for surgical intervention should not be deferred. The patients made full recovery at the time of discharge.
Maxillary Sinus Osteoma: A Rare Cause of Headache
Authors: Mittal Vikrant , Kumar Navneet 
Published: September 2011

ABSTRACT
A 66-year-old male presented with right-sided facial pain and headache since one year. MRI brain showed a large bony lesion in right side of maxillary sinus. CT scan of the paranasal sinuses revealed maxillary sinus osteoma. The tumor was excised through an opening made in anterior wall of maxilla along with endoscopic guidance through nasal cavity. Postoperative period was uneventful. The pathogenesis and various treatment modalities for maxillary sinus osteomas have been discussed.
Genomic Insights into the Role of TOP Gene Family in Soft‐Tissue Sarcomas: Implications for Prognosis and Therapy
Authors: Wang Genchun , Gan Xin , Chen Xin , Zeng Qunqian , Zhang Zhuoran , Li Jiantao , Guo Zhou , Hou Liang Cai , Xu JingTing , Kang Hao , Guo Fengjing 
Published: June 2024

AbstractThis study focuses on the role of topoisomerases (TOPs) in sarcomas (SARCs), highlighting TOPs' influence on sarcoma prognosis through mRNA expression, genetic mutations, immune infiltration, and DNA methylation analysis using transcriptase sequencing and other techniques. The findings indicate that TOP gene mutations correlate with increased inflammation, immune cell infiltration, DNA repair abnormalities, and mitochondrial fusion genes alterations, all of which negatively affect sarcoma prognosis. Abnormal TOP expression may independently affect sarcoma patients' survival. Cutting‐edge genomic tools such as Oncomine, gene expression profiling interactive analysis (GEPIA), and cBio Cancer Genomics Portal (cBioPortal) are utilized to explore the TOP gene family (TOP1/1MT/2A/2B/3A/3B) in soft‐tissue sarcomas (STSs). This in‐depth analysis reveals a notable upregulation of TOP mRNA in STS patients arcoss various SARC subtypes, French Federation Nationale des Centres de Lutte Contre le Cancer classification (FNCLCC) grades, and specific molecular profiles correlating with poorer clinical outcomes. Furthermore, this investigation identifies distinct patterns of immune cell infiltration, genetic mutations, and somatic copy number variations linked to TOP genes that inversely affect patient survival rates. These findings underscore the diagnostic and therapeutic relevance of the TOP gene suite in STSs.
Phloroglucinol–2,6‐Diaminoanthraquinone as a Durable Redox Mediator for Enhancing Conversion Reaction Kinetics in Lithium‐Sulfur Batteries
Authors: Lai Tianxing , Manthiram Arumugam 
Published: June 2024

AbstractLithium‐sulfur batteries, despite being a promising solution for next‐generation secondary batteries, require substantial efforts to overcome the challenges of sluggish sulfur redox kinetics, polysulfides shuttling, and Li metal instability before achieving practical viability. Conventional strategies that utilize metal catalysts or soluble redox mediators (RMs) are limited by either impractical producing processes or unsatisfactory service life. Herein, an electrochemically active organic material, phloroglucinol – 2,6‐diaminoanthraquinone (PG‐DAAQ) is synthesized through a green and facile polymerization process to better resolve these issues. Serving as an RM at the cathode, PG‐DAAQ exhibits enduring redox activity within the sulfur operating potential window, leading to enhanced redox kinetics and sulfur utilization. Remarkably, even without any metal elements, PG‐DAAQ exhibits an excellent affinity to polysulfides, thereby suppressing the shuttling and facilitating the formation of a more favorable solid‐electrolyte interface to stabilize Li deposition at the anode. As a result, Li‐S cells employing PG‐DAAQ show significantly enhanced cycling and rate performances than the control cells. Even with a low electrolyte‐to‐sulfur ratio of 6, pouch cells with PG‐DAAQ deliver a reversible discharge capacity of 821 mA h g−1 after 100 cycles at a C/10 rate.