bluuebunny/crossref_metadata_2025_split huggingface dataset:
Care clusters in mental health and co‐production of care – towards a more lay friendly set of cluster descriptions
Authors: Denham‐Vaughan Sally , Clark Michael 
Published: May 2012

PurposeThis paper aims to critically examine the care clusters descriptors now being introduced in mental health care in England and to discuss them in the context of trying to further approaches to co‐production (and related concepts), and social inclusion and recovery. The paper seeks to introduce a revised set of cluster descriptors that are more lay friendly and that, hence, would be likely to encourage more service user engagement in care.Design/methodology/approachThe care cluster descriptors are critically examined within the context of desires to engage service users in care and encourage staff to explicitly consider individual strengths as well as needs, i.e. co‐production of care between active service users and providers.FindingsThe implementation of care clusters and the development of new organisations of care based on these present opportunities to further develop in progressive ways how care is planned and developed. The cluster descriptors, however, are not an ideal basis for this. Being designed for one purpose the descriptors do not encourage thinking about individual strengths nor are they very lay friendly. They are not seen as an ideal basis for more actively engaging individuals in the planning and organisation of their care packages. Hence, revised descriptors felt to be more suited to this are presented.Practical implicationsFurthering more recovery oriented and socially inclusive practice in mental health care requires that each part of the system encourages all individuals involved to think in these ways. As the starting point for thinking about care, it is essential that cluster descriptors also work in this way. Services need to consider how the existing cluster descriptors impact on how individual care is thought of and delivered and consider using revised ones for some purposes, especially for engaging individuals in their care.Originality/valueThe care clusters being introduced in mental health care in England need to support progressive developments in care. This is the first time the cluster descriptors have been critiqued from the perspectives of recovery orientation and co‐production.
Arts management/marketing journal citation analysis: assessing external impact
Authors: Rentschler Ruth , Kirchner Theresa A. 
Published: May 2012

PurposeThis paper aims to present a quantitative analysis of arts management/marketing articles in leading general management/marketing journals, including an examination of the extent to which those top tier journal articles on arts/culture‐related topics cite authors of leading arts management journal articles.Design/methodology/approachUsing bibliometric techniques, this study examines the content of 20 top tier management and marketing journals over 22 years to identify articles published on arts management/marketing, which authors were cited, and from which arts management/marketing journals.FindingsAnalysis indicates that: relatively few citations in the top management/marketing journals reference arts management/marketing journals; assessment of interaction between the parent management/marketing disciplines and the arts management/marketing sub‐discipline indicates that authors draw upon a large reserve of diverse literatures; and top journal arts‐related management/marketing articles tend to utilize citations to journal articles grounded in the social sciences and aesthetics of management, with an increasing trend of citations to arts management/marketing journals.Research limitations/implicationsThis study of the extent to which top journals have published arts/culture‐related articles and the citation impact of arts management/marketing journals is the initial academic study on the topic and suggests opportunities for further research.Practical implicationsAnalysis of arts management/marketing journal impact contributes to professionalization of the field and increased perceived value of those journals by industry practitioners.Originality/valueThis research is the first to examine the spectrum of arts management/marketing literature, including both top general management/marketing journals and sector‐oriented arts management/marketing journals, establishing a body of knowledge for augmentation by future research over time.
Meanderings into the Regulation of Effector Class by the Immune System: Derivation of the Trauma Model
Authors: Cohn M. 
Published: May 2012

AbstractThe pathway of immune system behaviour can be divided into three modules, each with its own logic and database. The modules are related in that they feed sequentially into each other for function. The modules are (1) the generation of the recognitive repertoire; (2) the sorting of the repertoire by purging it of anti‐self; and (3) the coupling of the residue, anti‐nonself, appropriately to the biodestructive and ridding effector functions. While both the generation and sorting of the repertoire have been intensively investigated and are well understood in terms of firm theoretical frameworks, the understanding of Module 3, the regulation of effector class, is patchy. This essay is an attempt to define the elements required for an understanding of Module 3 and that leads us to propose the Trauma Model.
Induction of Immune‐related Gene Expression in Ctenopharyngodon idella Kidney Cells by Secondary Metabolites from Immunostimulatory Alcaligenes faecalis FY‐3
Authors: Wu Z.‐F. , Liu G.‐L. , Zhou Z. , Wang G.‐X. , Xia L. , Liu J.‐L. 
Published: May 2012

AbstractThis study was undertaken to isolate active secondary metabolites from immunostimulatory Alcaligenes faecalis FY‐3 and evaluate their activities using grass carp Ctenopharyngodon idella kidney (CIK) cells. By applying chromatography techniques and successive recrystallization, three purified metabolites were obtained and identified by spectral data (mass spectrometry and nuclear magnetic resonance) as: (1) phenylacetic acid, (2) p‐hydroxyphenylacetylamide and (3) cyclo‐(Gly‐L‐Pro). CIK cells were stimulated by different concentrations (1, 10 and 100 μg/ml) of the isolated compounds, and expression of MyD88, IL‐1β, TNF‐α, type I‐IFN and IL‐8 genes at different time points (2, 8 and 24 h) post‐stimulation was quantified by real‐time PCR. The known immunostimulatory agent lipopolysaccharide (LPS) was used as a positive control. To analyse whether these compounds are toxic to the cells, the methyl tetrazolium assay was employed to measure changes in cell viability. The obtained results revealed that transcribing level of MyD88, an important adaptor molecule in toll‐like receptor signalling pathway, was augmented remarkably by all the three isolated compounds and LPS as early as 2‐h exposure. These compounds also induced gene expression of cytokines such as IL‐1β, TNF‐α and type I‐IFN. Under the experimental conditions, none of the test compounds is toxic to the CIK cells. These findings demonstrate that the immunostimulatory properties of the three metabolites [phenylacetic acid, p‐hydroxyphenylacetylamide and cyclo‐(Gly‐L‐Pro)] from A. faecalis FY‐3 in CIK cells and highlight the potential of using these metabolites as immunostimulants in fish aquaculture.
Specific changes in total and mitochondrial proteomes are associated with higher levels of heterosis in maize hybrids
Authors: Dahal Diwakar , Mooney Brian P. , Newton Kathleen J. 
Published: May 2012

SummaryThe phenomenon of hybrid vigor (heterosis) has long been harnessed by plant breeders to improve world food production. However, the changes that are essential for heterotic responses and the mechanisms responsible for heterosis remain undefined. Large increases in biomass and yield in high‐heterosis hybrids suggest that alterations in bioenergetic processes may contribute to heterosis. Progeny from crosses between various inbred lines vary in the extent of vigor observed. Field‐grown maize F1 hybrids that consistently exhibited either low or high heterosis across a variety of environments were examined for changes in proteins that may be correlated with increased plant vigor and yield. Unpollinated ears at the time of flowering (ear shoots) were selected for the studies because they are metabolically active, rich in mitochondria, and the sizes of the ears are diagnostic of yield heterosis. Total protein and mitochondrial proteomes were compared among low‐ and higher‐heterosis hybrids. Two‐dimensional difference gel electrophoresis was used to identify allelic and/or isoform differences linked to heterosis. Identification of differentially regulated spots by mass spectrometry revealed proteins involved in stress responses as well as primary carbon and protein metabolism. Many of these proteins were identified in multiple spots, but analysis of their abundances by label‐free mass spectrometry suggested that most of the expression differences were due to isoform variation rather than overall protein amount. Thus, our proteomics studies suggest that expression of specific alleles and/or post‐translational modification of specific proteins correlate with higher levels of heterosis.
Detection and Molecular Diversity of Pantoea ananatis Associated with White Spot Disease in Maize, Sorghum and Crabgrass in Brazil
Authors: Lana Ubiraci Gomes De Paula , Gomes Eliane Aparecida , Silva Dagma Dionísia , Costa Rodrigo Veras , Cota Luciano Viana , Parreira Douglas Ferreira , Souza Isabel Regina Prazeres , Guimarães Claudia Teixeira 
Published: May 2012

AbstractBacteria of the genus Pantoea have become important plant pathogens worldwide in recent years. Pantoea ananatis was reported as the cause of maize white spot, a serious maize disease in Brazil, causing significant yield losses. However, very little information is available about how to detect this pathogen, its genetic variability and the putative alternative hosts in maize‐growing areas. To address these issues, we implemented a rapid and efficient PCR‐based method to identify P. ananatis isolated from leaves showing white spot symptoms and evaluated its genetic diversity in maize, sorghum and crabgrass. Of the 29 bacteria isolated from typical water‐soaked lesions of white spot disease that produced yellow colonies, 15 isolates were identified as P. ananatis by 16S rDNA sequencing and correctly detected by the PCR reaction, amplifying a specific fragment of the ice nucleation gene (ina). These P. ananatis isolates included 13 from maize, one from sorghum and one from crabgrass, while the other 14 yellow colony isolates were from other bacterial species, including two Pantoea species (Pantoea dispersa and Pantoea agglomerans) that were not amplified by the ina primers. These results indicate that the optimized PCR assay can be used to detect P. ananatis isolated from white spot lesions and could be used as a large‐scale and cost‐effective method of detecting this pathogen in leaf lesions on maize and other grasses. All isolates were evaluated for hypersensitive response (HR) on tobacco, revealing that some P. ananatis were able to induce HR. The high genetic variability revealed by rep‐PCR did not differentiated the P. ananatis isolates based on their hosts or HR reaction. The detection, characterization and diversity of P. ananatis from maize, sorghum and crabgrass in our study can be applied in understanding epidemiology and designing control strategies for maize white spot disease in Brazil.
Measuring quality of life impairment in skeletal muscle channelopathies
Authors: Sansone V. A. , Ricci C. , Montanari M. , Apolone G. , Rose M. , Meola G. ,   INQoL Group
Published: May 2012

Background and purposeFatigue and pain have been previously shown to be important determinants for decreasing quality of life (QoL) in one report in patients with non‐dystrophic myotonia. The aims of our study were to assess QoL in skeletal muscle channelopathies (SMC) using INQoL (individualized QoL) and SF‐36 questionnaires.MethodsWe administered INQoL and SF‐36 to 66 Italian patients with SMC (26: periodic paralysis, 36: myotonia congenita and 4: Andersen‐Tawil) and compared the results in 422 patients with myotonic dystrophies (DM1: 382; and DM2: 40).Results(i) INQoL index in SMC is similar to that in DMs (P = 0.79). (ii) Patients with myotonia congenita have the worst perception of QoL. (iii) Myotonia has the most detrimental effect on patients with myotonia congenita, followed by patients with DM2 and then by patients with DM1 and hyperkalemic periodic paralysis. (iv) Pain is a significant complaint in patients with myotonia congenita, hypokalemic periodic paralysis and DM2 but not in DM1. (v) Fatigue has a similar detrimental effect on all patient groups except for patients with hyperkalemic periodic paralysis in whom muscle weakness and myotonia more than fatigue affect QoL perception. (vi) Muscle symptoms considered in INQoL correlate with physical symptoms assessed by SF‐36 (R from −0.34 to −0.76).ConclusionsQoL perception in patients with SMC is similar to that of patients with DMs, chronic multisystem disabling conditions. Our results provide information to target treatment and health care of these patients. The sensitivity of INQoL to changes in QoL in the SMC needs to be further explored in longitudinal studies.
Preconditioning induces tolerance by suppressing glutamate release in neuron culture ischemia models
Authors: Tauskela Joseph S. , Aylsworth Amy , Hewitt Melissa , Brunette Eric , Mealing Geoffrey A. R. 
Published: May 2012

J. Neurochem. (2012) 122, 470–481.AbstractThis study determined how preconditioned neurons responded to oxygen‐glucose deprivation (OGD) to result in neuroprotection instead of neurotoxicity. Neurons preconditioned using chronically elevated synaptic activity displayed suppressed elevations in extracellular glutamate ([glutamateex]) and intracellular Ca2+ (Ca2+in) during OGD. The glutamate uptake inhibitor TBOA induced neurotoxicity, but at a longer OGD duration for preconditioned cultures, suggestive of delayed up‐regulation of transporter activity relative to non‐preconditioned cultures. This delay was attributed to a critically attenuated release of glutamate, based on tolerance observed against insults mimicking key neurotoxic signaling during OGD (OGD‐mimetics). Specifically, in the presence of TBOA, preconditioned neurons displayed potent protection to the OGD‐mimetics: ouabain (a Na+/K+ ATPase inhibitor), high 55 mM KCl extracellular buffer (plasma membrane depolarization), veratridine (a Na+ ionophore), and paraquat (intracellular superoxide producer), which correlated with suppressed [glutamateex] elevations in the former two insults. Tolerance by preconditioning was reversed by manipulations that increased [glutamateex], such as by exposure to TBOA or GABAA receptor agonists during OGD, or by exposure to exogenous NMDA or glutamate. Pre‐synaptic suppression of neuronal glutamate release by preconditioning, possibly via suppressed exocytic release, represents a key convergence point in neuroprotection during exposure to OGD and OGD‐mimetics.
A Prospective, Randomized Comparison of Modified Pulmonary Vein Isolation Versus Conventional Pulmonary Vein Isolation in Patients with Paroxysmal Atrial Fibrillation
Authors: LIN YENN‐JIANG , CHANG SHIH‐LIN , LO LI‐WEI , HU YU‐FENG , SUENARI KAZUYOSHI , LI CHENG‐HUNG , CHAO TZE‐FAN , CHUNG FA‐PO , LIAO JO‐NAN , HARTONO BENY , TSO HAN‐WEN , TSAO HSUAN‐MING , HUANG JIN‐LONG , KAO TSAIR , CHEN SHIH‐ANN 
Published: May 2012

Modified Pulmonary Vein Isolation in AF Ablation. Introduction: Pulmonary vein isolation (PVI) is the primary ablation therapy in patients with atrial fibrillation (AF). We hypothesized that high dominant frequency (DF) sites (AF nests during sinus rhythm [SR]) adjacent to the PV ostia are associated with the atrial substrate that maintains AF, and PVI incorporating the high‐frequency AF nests may have a higher efficacy.Methods and Results: In a prospective and randomized comparison, 126 symptomatic paroxysmal AF patients that underwent PVI were enrolled. We compared the efficacy of a modified PVI (ablation line: 1.0–1.5 cm from the PV ostium with encircling the AF nests [spectral analysis with DF >70 Hz during SR, Group II]) versus the anatomy‐guided conventional PVI (Group I). In Group II, the DF value along the PV ostium was lower than 70 Hz after the PVI. The primary endpoint was the freedom from symptomatic atrial arrhythmias after a single procedure. We also followed the autonomic function by a time‐domain analysis of the heart rate variability. In both groups, AF nests were observed and electric isolation was successfully obtained in all patients. With a mean duration of 16 ± 6.1 months of follow‐up, Group II had a higher single procedure efficacy without drugs (78.7% vs 66.1%, log‐rank test: P = 0.02), and fewer repeat procedures (6.6% vs 23%; P = 0.04), as compared to Group I.Conclusion: PVI incorporating the high frequency AF nests adjacent to the PV ostia had a better single procedure efficacy. (J Cardiovasc Electrophysiol, Vol. 23, pp. 1155–1162, November 2012)
The effect of systemically administrated zoledronic acid on the osseointegration of dental implants
Authors: Ayan M , Dolanmaz D , Mihmanlı A , Ayan A , Kürkçü M 
Published: May 2012

Oral Diseases (2012) 18, 802–808Objective:  The aim of conducting this study was to evaluate the effect of zoledronic acid (ZA) on the new bone formation (NBF) after the insertion of a titanium dental implant, which is very popular treatment in dentistry.Study Design:  Twelve New Zealand white rabbits were used in this study. The rabbits were divided in two groups. ZA was systemically administered to the study group. Titanium implants were placed to the left and right tibias of the rabbits.Results:  The data from the ZA group revealed a statistically significant increase in the bone mineral content and the bone mineral density. A non‐decalcified histomorphometric examination conducted on the study group revealed a significant increase of NBF and bone‐implant contact (BIC) at 2 and 4 weeks.Conclusion:  A single dose of systemic ZA administration increases the rate of NBF and augments the quality of the bone.
The fruit fly Drosophila melanogaster unfolds the secrets of innate immunity
Authors: Rämet Mika 
Published: May 2012

AbstractIn 2011, the Nobel Prize in Physiology and Medicine was rewarded, in part, for research on the Drosophila immune response. The research described the role of the Drosophila Toll receptor in antifungal resistance, and the subsequent characterization of Toll‐like receptors in mammals reshaped our understanding of the immune system. This review summarizes the potential of the Drosophila model and describes the path that has lead Drosophila to become an important model to study immunity.Conclusion:  Drosophila melanogaster has been one of the most fruitful models to study innate immunity.
Genetic diversity and population genetic analysis of bovine MHC class II DRB3.2 locus in three Bos indicus cattle breeds of Southern India
Authors: Das D. N. , Sri Hari V. G. , Hatkar D. N. , Rengarajan K. , Saravanan R. , Suryanarayana V. V. S. , Murthy L. K. 
Published: May 2012

SummaryThe present study was performed to evaluate the genetic polymorphism of BoLA‐DRB3.2 locus in Malnad Gidda, Hallikar and Ongole South Indian Bos indicus cattle breeds, employing the PCR‐RFLP technique. In Malnad Gidda population, 37 BoLA‐DRB3.2 alleles were detected, including one novel allele DRB3*2503 (GenBank: HM031389) that was observed in the frequency of 1.87%. In Hallikar and Ongole populations, 29 and 21 BoLA‐DRB3.2 alleles were identified, respectively. The frequencies of the most common BoLA‐DRB3.2 alleles (with allele frequency > 5%), in Malnad Gidda population, were DRB3.2*15 (10.30%), DRB3*5702 (9.35%), DRB3.2*16 (8.41%), DRB3.2*23 (7.01%) and DRB3.2*09 (5.61%). In Hallikar population, the most common alleles were DRB3.2*11 (13.00%), DRB3.2*44 (11.60%), DRB3.2*31 (10.30%), DRB3.2*28 (5.48%) and DRB3.2*51 (5.48%). The most common alleles in Ongole population were DRB3.2*15 (22.50%), DRB3.2*06 (20.00%), DRB3.2*13 (13.30%), DRB3.2*12 (9.17%) and DRB3.2*23 (7.50%). A high degree of heterozygosity observed in Malnad Gidda (HO = 0.934, HE = 0.955), Hallikar (HO = 0.931, HE = 0.943) and Ongole (HO = 0.800, HE = 0.878) populations, along with FIS values close to FIS zero (Malnad Gidda: FIS = 0.0221, Hallikar: FIS = 0.0127 and Ongole: FIS = 0.0903), yielded nonsignificant P‐values with respect to Hardy–Weinberg equilibrium probabilities revealing, no perceptible inbreeding, greater genetic diversity and characteristic population structure being preserved in the three studied cattle populations. The phylogenetic tree constructed based on the frequencies of BoLA‐DRB3.2 alleles observed in 10 Bos indicus and Bos taurus cattle breeds revealed distinct clustering of specific Bos indicus cattle breeds, along with unique genetic differentiation observed among them. The results of this study demonstrated that the BoLA‐DRB3.2 is a highly polymorphic locus, with significant breed‐specific genetic diversities being present amongst the three studied cattle breeds. The population genetics and phylogenetic analysis have revealed pivotal information about the population structure and importance of the presently studied three Bos indicus cattle breeds as unique animal genetic resources, which have to be conserved for maintaining native cattle genetic diversity.
Angiotensin‐converting enzyme (ACE) gene II genotype protects against the development of diabetic peripheral neuropathy in type 2 diabetes mellitus
Authors: MANSOOR Qaisar , JAVAID Amara , BILAL Nighat , ISMAIL Muhammad 
Published: May 2012

AbstractBackground:  Diabetic peripheral neuropathy (DPN) is one of the complications of type 2 diabetes mellitus (T2DM) that decreases the quality of life of T2DM patients. Very few studies have found an association between the development and progression of DPN in T2DM and angiotensin‐converting enzyme (ACE) gene insertion/deletion (I/D) polymorphisms.Methods:  Using gene‐specific primers in a polymerase chain reaction, the presence of ACE I/D polymorphisms was screened for in 276 T2DM patients with DPN, 496 T2DM patients without DPN, and 331 control (non‐diabetic) subjects.Results:  The distribution of the I/D genotypes was in Hardy–Weinberg equilibrium. The II genotype was significantly more prevalent in T2DM patients without DPN than the DD genotype (P < 0.05); however, there was no significant difference in the prevalence of the II and DD genotypes in T2DM patients with DPN (P = 0.78).Conclusion:  The II genotype of the ACE gene has a protective effect against the development of DPN in T2DM patients. This suggests a role for the renin–angiotensin system in modulating neuropathy in T2DM.
Thermal Inactivation of Infectious Hepatitis E Virus in Experimentally Contaminated Food
Authors: Barnaud Elodie , Rogée Sophie , Garry Pascal , Rose Nicolas , Pavio Nicole 
Published: May 2012

ABSTRACT

Hepatitis E virus (HEV) infection of zoonotic origin is an emerging concern in industrialized countries. In the past few years, several cases of zoonotic hepatitis E have been identified and the consumption of food products derived from pork liver have been associated with clusters of human cases. More specifically, raw or undercooked pork products have been incriminated. Few data on the effect of heating on HEV inactivation in food products are available. In the present study, the various times and temperatures that are used during industrial processing of pork products were applied to experimentally contaminated food preparations. After treatment, the presence of residual infectious virus particles was investigated using real-time reverse transcription-PCR and an
in vivo
experimental model in pigs. Results show that heating the food to an internal temperature of 71°C for 20 min is necessary to completely inactivate HEV. These results are very important for determining processing methods to ensure food safety in regard to food-borne hepatitis E.