bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of Accuracy of Implant Placement Using Surgical Stent Versus Conventional Technique
Authors: Basannavar Amit Ashok , Konwar Annesha K. , Pal Sunil , Ishaq Aasima , Kondreddy Kameswari , Shinde Samidha M. , Tiwari Rahul 
Published: June 2024

ABSTRACT

Purpose:
The aim of this study was to assess the accuracy of the implant placement using surgical stents versus conventional implant placement.

Materials and Methods:
Twenty patients who reported to Rajarajeswari Dental College and Hospital were selected and they were randomly divided into two groups. In both the groups, the selection of the implant size was based on the ridge mapping. In Group I, tooth and tissue-supported surgical stent was fabricated and was used to place the implant. In Group II conventional technique was used for implant placement.

Results:
In Group I the implant placement was parallel to the adjacent tooth with less variation in the angulation and the mesiodistal orientation of the implant was statistically significant compared to Group II.

Conclusion:
This technique of stent fabrication is easy, reliable, and cost-effective which also aids in the ideal placement of the implant in terms of orientation and angulation.
Zoonotic Disease Risk Perception and Infection Control Practices amongst Veterinarians in Kerala, India
Authors: Mithun T. K. , Lal S. S. , Nayar K. Rajasekharan 
Published: June 2024

AbstractIntroduction:Veterinarians could act as the sentinel for the study of zoonotic diseases. This study evaluates the prevalence of zoonoses amongst Kerala veterinarians and explores infection control measures they use to protect themselves and the factors influencing their infection control practices.Materials and Methods:It is a quantitative cross-sectional study using proportionate sampling with a self-administered questionnaire.Results:About 31.1% of veterinarians experienced symptoms of zoonotic diseases, with dermatophytosis being the most common. Handling tissues, bodily fluids and excretions of animals were the highest risk-carrying procedures. However, the majority of respondents did hand wash, whereas some never properly disposed of used needles. Factors such as heat stress, comfort, cost and time of consultation discouraged one-fourth of participants from using personal protective equipment.Conclusion:Failure to follow infection control practices contributes to the prevalence of zoonoses amongst veterinarians in Kerala. Reasons for this failure include the absence of better policies to address veterinarian’s issues. There is a need for more effective enforcement of infection control policy for the veterinarians.
Development of generic yoga therapy protocol for nonspecific chronic low back pain
Authors: Nilachal Padmashanti , Bhavanani Ananda Balayogi , Ramanathan Meena , Mohanakrishnan Jagadevan , Bhatt Arpan , Srivastava Vandana , Dhanasekaran Rajarajan 
Published: June 2024

ABSTRACT

Objective:
To develop a generic yoga therapy protocol for nonspecific chronic low back pain (NCLBP) on the basis of previous research studies.

Methods:
A comprehensive PubMed search was done using keywords of “yoga” and “back pain” for English-language articles published till November 2022. PubMed showed 332 results for the keywords from 1977 to 2022. Twenty-nine studies were found eligible and the consolidation of yogic techniques were used in the studies. The study compiled 72 yogic techniques, including Asana and Pranayama, from 332 articles on yoga and back pain. Out of these, 151 were not relevant to yoga or back pain. After analyzing 181 articles, 33 were selected for review for a yoga therapy protocol, with four excluded due to inability to access full-text articles. The protocol was later validated by 14 eminent yoga therapy experts across the globe from countries including Australia, France, USA, Canada, Italy, Switzerland, and India, who had a minimum of 10 years’ experience in the field. The validation of the techniques was done based on a questionnaire that required classification under three categories: (1) not necessary, (2) useful but not essential, and (3) essential. All the three categories were then segregated in decreasing order of “Essential percentage” and “Weightage percentage” and the final list developed. The cutoff was that the yogic techniques must have ≥50% of acceptance by all experts. The practices were then sequenced in order of performance and cross referenced with traditional teachings.

Results:
The Generic Yoga Therapy Protocol for NCLBP that has been developed through this rational and logical mechanism has 18 yogic techniques selected on the basis of weightage and essential percentage. It includes 13 standing, sitting, prone, and supine postures (Asanas), four energy modulating breathing practices (Pranayamas), and one relaxation. The Shavasan relaxation received 100% approval by all experts.

Conclusion:
This generic yoga therapy protocol for NCLBP was developed through a comprehensive methodology that took into account the techniques used in previous research studies and was consolidated after a method of scientific validation by 14 eminent yoga therapy experts.
Complement factor I knockdown inhibits colon cancer development by affecting Wnt/β-catenin/c-Myc signaling pathway and glycolysis
Authors: Du Yong-Jun , Jiang Yue , Hou Yan-Mei , Shi Yong-Bo 
Published: June 2024

BACKGROUND
Colon cancer (CC) occurrence and progression are considerably influenced by the tumor microenvironment. However, the exact underlying regulatory mechanisms remain unclear.
AIM
To investigate immune infiltration-related differentially expressed genes (DEGs) in CC and specifically explored the role and potential molecular mechanisms of complement factor I (CFI).
METHODS
Immune infiltration-associated DEGs were screened for CC using bioinformatics. Quantitative reverse transcription polymerase chain reaction was used to examine hub DEGs expression in the CC cell lines. Stable CFI-knockdown HT29 and HCT116 cell lines were constructed, and the diverse roles of CFI in vitro were assessed using CCK-8, 5-ethynyl-2’-deoxyuridine, wound healing, and transwell assays. Hematoxylin and eosin staining and immunohistochemistry staining were employed to evaluate the influence of CFI on the tumorigenesis of CC xenograft models constructed using BALB/c male nude mice. Key proteins associated with glycolysis and the Wnt pathway were measured using western blotting.
RESULTS
Six key immune infiltration-related DEGs were screened, among which the expression of CFI, complement factor B, lymphoid enhancer binding factor 1, and SRY-related high-mobility-group box 4 was upregulated, whereas that of fatty acid-binding protein 1, and bone morphogenic protein-2 was downregulated. Furthermore, CFI could be used as a diagnostic biomarker for CC. Functionally, CFI silencing inhibited CC cell proliferation, migration, invasion, and tumor growth. Mechanistically, CFI knockdown downregulated the expression of key glycolysis-related proteins (glucose transporter type 1, hexokinase 2, lactate dehydrogenase A, and pyruvate kinase M2) and the Wnt pathway-related proteins (β-catenin and c-Myc). Further investigation indicated that CFI knockdown inhibited glycolysis in CC by blocking the Wnt/β-catenin/c-Myc pathway.
CONCLUSION
The findings of the present study demonstrate that CFI plays a crucial role in CC development by influencing glycolysis and the Wnt/β-catenin/c-Myc pathway, indicating that it could serve as a promising target for therapeutic intervention in CC.
Dynamic contrast enhanced ultrasound in differential diagnosis of hepatocellular carcinoma: A systematic review and meta-analysis
Authors: Esposto Giorgio , Santini Paolo , Termite Fabrizio , Galasso Linda , Mignini Irene , Ainora Maria Elena , Gasbarrini Antonio , Zocco Maria Assunta 
Published: June 2024

BACKGROUND
Non-invasive differential diagnosis between hepatocellular carcinoma (HCC) and other liver cancer (i.e. cholangiocarcinoma or metastasis) is highly challenging and definitive diagnosis still relies on histological exam. The patterns of enhancement and wash-out of liver nodules can be used to stratify the risk of malignancy only in cirrhotic patients and HCC frequently shows atypical features. Dynamic contrast-enhanced ultrasound (DCEUS) with standardized software could help to overcome these obstacles, providing functional and quantitative parameters and potentially improving accuracy in the evaluation of tumor perfusion.
AIM
To explore clinical evidence regarding the application of DCEUS in the differential diagnosis of liver nodules.
METHODS
A comprehensive literature search of clinical studies was performed to identify the parameters of DCEUS that could relate to histological diagnosis. In accordance with the study protocol, a qualitative and quantitative analysis of the evidence was planned.
RESULTS
Rise time was significantly higher in HCC patients with a standardized mean difference (SMD) of 0.83 (95%CI: 0.48-1.18). Similarly, other statistically significant parameters were mean transit time local with a SMD of 0.73 (95%CI: 0.20-1.27), peak enhancement with a SMD of 0.37 (95%CI: 0.03-0.70), area wash-in area under the curve with a SMD of 0.47 (95%CI: 0.13-0.81), wash-out area under the curve with a SMD of 0.55 (95%CI: 0.21-0.89) and wash-in and wash-out area under the curve with SMD of 0.51 (95%CI: 0.17-0.85). SMD resulted not significant in fall time and wash-in rate, but the latter presented a trend towards greater values in HCC compared to intrahepatic cholangiocarcinoma.
CONCLUSION
DCEUS could improve non-invasive diagnosis of HCC, leading to less liver biopsy and early treatment. This quantitative analysis needs to be applied on larger cohorts to confirm these preliminary results.
Trends and hotspots in gastrointestinal neoplasms risk assessment: A bibliometric analysis from 1984 to 2022
Authors: Fu Qiang-Qiang , Ma Le , Niu Xiao-Min , Zhao Hua-Xin , Ge Xu-Hua , Jin Hua , Yu De-Hua , Yang Sen 
Published: June 2024

BACKGROUND
Gastrointestinal neoplasm (GN) significantly impact the global cancer burden and mortality, necessitating early detection and treatment. Understanding the evolution and current state of research in this field is vital.
AIM
To conducts a comprehensive bibliometric analysis of publications from 1984 to 2022 to elucidate the trends and hotspots in the GN risk assessment research, focusing on key contributors, institutions, and thematic evolution.
METHODS
This study conducted a bibliometric analysis of data from the Web of Science Core Collection database using the "bibliometrix" R package, VOSviewer, and CiteSpace. The analysis focused on the distribution of publications, contributions by institutions and countries, and trends in keywords. The methods included data synthesis, network analysis, and visualization of international collaboration networks.
RESULTS
This analysis of 1371 articles on GN risk assessment revealed a notable evolution in terms of research focus and collaboration. It highlights the United States' critical role in advancing this field, with significant contributions from institutions such as Brigham and Women's Hospital and the National Cancer Institute. The last five years, substantial advancements have been made, representing nearly 45% of the examined literature. Publication rates have dramatically increased, from 20 articles in 2002 to 112 in 2022, reflecting intensified research efforts. This study underscores a growing trend toward interdisciplinary and international collaboration, with the Journal of Clinical Oncology standing out as a key publication outlet. This shift toward more comprehensive and collaborative research methods marks a significant step in addressing GN risks.
CONCLUSION
This study underscores advancements in GN risk assessment through genetic analyses and machine learning and reveals significant geographical disparities in research emphasis. This calls for enhanced global collaboration and integration of artificial intelligence to improve cancer prevention and treatment accuracy, ultimately enhancing worldwide patient care.
Analysis of quality of life in patients after transgastric natural orifice transluminal endoscopic gallbladder-preserving surgery
Authors: Zhang Min-Yu , Zheng Sen-Yuan , Ru Zheng-Yu , Zhang Zhi-Qiang 
Published: June 2024

BACKGROUND
At present, laparoscopic cholecystectomy (LC) is the main surgical treatment for gallstones. But, after gallbladder removal, there are many complications. Therefore, it is hoped to remove stones while preserving the function of the gallbladder, and with the development of endoscopic technology, natural orifice transluminal endoscopic surgery came into being.
AIM
To compare the quality of life, perioperative indicators, adverse events after LC and transgastric natural orifice transluminal endoscopic gallbladder-preserving surgery (EGPS) in patients with gallstones.
METHODS
Patients who were admitted to The First Affiliated Hospital of Xinjiang Medical University from 2020 to 2022 were retrospectively collected. We adopted propensity score matching (1:1) to compare EGPS and LC patients.
RESULTS
A total of 662 cases were collected, of which 589 cases underwent LC, and 73 cases underwent EGPS. Propensity score matching was performed, and 40 patients were included in each of the groups. In the EGPS group, except the gastrointestinal defecation (P = 0.603), the total score, physical well-being, mental well-being, and gastrointestinal digestion were statistically significant compared with the preoperative score after surgery (P < 0.05). In the LC group, except the mental well-being, the total score, physical well-being, gastrointestinal digestion, the gastrointestinal defecation was statistically significant compared with the preoperative score after surgery (P < 0.05). When comparing between groups, gastrointestinal defecation had significantly difference (P = 0.002) between the two groups, there was no statistically significant difference in the total postoperative score and the other three subscales. In the surgery duration, hospital stay and cost, LC group were lower than EGPS group. The recurrence factors of gallstones after EGPS were analyzed: and recurrence was not correlated with gender, age, body mass index, number of stones, and preoperative score.
CONCLUSION
Whether EGPS or LC, it can improve the patient’s symptoms, and the EGPS has less impact on the patient’s defecation. It needed to, prospective, multicenter, long-term follow-up, large-sample related studies to prove.
Long-term impact of artificial intelligence on colorectal adenoma detection in high-risk colonoscopy
Authors: Chow Kenneth W , Bell Matthew T , Cumpian Nicholas , Amour Maryanne , Hsu Ryan H , Eysselein Viktor E , Srivastava Neetika , Fleischman Michael W , Reicher Sofiya 
Published: June 2024

BACKGROUND
Improved adenoma detection rate (ADR) has been demonstrated with artificial intelligence (AI)-assisted colonoscopy. However, data on the real-world application of AI and its effect on colorectal cancer (CRC) screening outcomes is limited.
AIM
To analyze the long-term impact of AI on a diverse at-risk patient population undergoing diagnostic colonoscopy for positive CRC screening tests or symptoms.
METHODS
AI software (GI Genius, Medtronic) was implemented into the standard procedure protocol in November 2022. Data was collected on patient demographics, procedure indication, polyp size, location, and pathology. CRC screening outcomes were evaluated before and at different intervals after AI introduction with one year of follow-up.
RESULTS
We evaluated 1008 colonoscopies (278 pre-AI, 255 early post-AI, 285 established post-AI, and 190 late post-AI). The ADR was 38.1% pre-AI, 42.0% early post-AI (P = 0.77), 40.0% established post-AI (P = 0.44), and 39.5% late post-AI (P = 0.77). There were no significant differences in polyp detection rate (PDR, baseline 59.7%), advanced ADR (baseline 16.2%), and non-neoplastic PDR (baseline 30.0%) before and after AI introduction.
CONCLUSION
In patients with an increased pre-test probability of having an abnormal colonoscopy, the current generation of AI did not yield enhanced CRC screening metrics over high-quality colonoscopy. Although the potential of AI in colonoscopy is undisputed, current AI technology may not universally elevate screening metrics across all situations and patient populations. Future studies that analyze different AI systems across various patient populations are needed to determine the most effective role of AI in optimizing CRC screening in clinical practice.
School Supervisor Competence in Assessing Performance Principal of Junior High School Level
Authors: Liza Liza , Roesminingsih Erny , Hariyati Nunuk 
Published: June 2024

Objective: This study aims to describe and analyze data on the competence of school supervisors in carrying out school principals' performance assessments to create effective education units (Phenomenological Study in Sidoarjo). Method: This research uses a qualitative approach with the research subject, namely the Sidoarjo Regency Education Service supervisor at the Junior High School Level. The data collection technique in this research uses three data collection techniques, namely participant observation, in-depth interviews, and study of documents. Results: The assessment results show that the performance of school principals is critical in realizing an effective school. The school supervisor oversees the school principal's performance appraisal process. They start from collecting, processing, analyzing, and interpreting data about the quality of the school principal's work according to his duties as a school principal. School supervisors conduct managerial supervision to correct weaknesses in target schools through intensive training. School supervisors are one of the parts that are very influential in improving the quality of education in target schools. School supervisors always try to improve the ability of school management personnel in all aspects in order to obtain optimal quality education. Novelty: This study shows five competencies of school supervisors in carrying out performance assessments of school principals, namely personality, managerial supervision, academic supervision, educational evaluation, research and development, and social competence.
The Impact of Differentiated Learning, Adversity Intelligence, and Peer Tutoring on Student Learning Outcomes
Authors: Hidayat Nur , Ruhiat Yayat , Anriani Nurul , Suryadi Suryadi 
Published: June 2024

Objective: Differentiation is a well-recognized strategy that assists teachers in addressing the needs of students with varying abilities in a classroom of students with different characteristics. The research investigates the impact of differentiation learning, adversity intelligence, and peer tutoring on student learning outcomes. Method: This research employs a statistical survey approach to guarantee outcome accuracy. The researchers employed a partial least squares-structural equation model (PLS-SEM) to determine the values of latent variables to make predictions. The questionnaire was used as the data-gathering tool in this study. The investigation occurred at a vocational high school in Serang Regency in Banten Province, Indonesia. Were 250 students in the vocational high school in Serang Regency, Indonesia. The sampling procedure was conducted using a random approach. Results: The statistical study of the structural model indicates a considerable positive link between differentiated learning and adversity intelligence. Adversity intelligence and peer tutoring were positively correlated. Differentiated learning is positively correlated with learning outcomes. Learning outcomes are positively correlated with peer tutoring. Novelty: This research presents novelty research that combines differentiated learning, adversity intelligence, and peer tutoring to examine their impact on student learning outcomes. This research is novel in its attempt to incorporate multiple variables into a single unit for investigation and exploration. This research is intriguing due to variations in emphasis, research participants, and incorporation of research factors compared to earlier studies.
Exploring the Influence of Game-Based Learning and School Environment on Learning Achievement: Does the Mediation of Self-Intention Matter?
Authors: Atoulloh Atoulloh , Fitriani Aries , Daryono Rihab Wit 
Published: June 2024

Objective: This research aims to explore the influence of game-based learning and the school environment on student learning achievement and the mediating role of self-intention in influencing game-based learning and the school environment. Method: The quantitative survey method involved 100 students of MA Ma'arif Al-Mukarrom, Kauman, and Ponorogo, using probability sampling techniques with proportionate stratified sampling techniques. Data was collected through a questionnaire with a Likert scale, and data analysis was carried out using relevant statistical techniques. Results: The research results show a positive but less significant influence on game-based learning and the school environment on student learning achievement; however, with self-intention mediating it, it has a positive and significant influence. The implications of this research include the importance of developing learning strategies to improve more effective and efficient education and a school environment that can support learning. Recommendations for research are the need to integrate elements of motivation and self-development in game-based learning design and develop meta-cognitive skills. The final one is creating a school environment to create an atmosphere of motivation and social support and facilitate learning experiences. Novelty: This research highlights the role of student enthusiasm in connecting learning through games, school atmosphere, and learning achievement. This adds insight into the interaction of these factors and underlines the importance of paying attention to students' enthusiasm for learning.
Implementation of the School Curriculum to Empower Education in the Digital Era 4.0 for Quality Human Resources
Authors: Sari Febriani Dwi , Rugaiyah Rugaiyah 
Published: June 2024

Objective: The development of the digitalization era cannot be avoided. The development of science in various fields, mainly Information and Communication Technology (ICT), is rapidly increasing. An educator needs to update and introduce students to be more technology literate. One is implementing a curriculum that empowers education in the digital era 4.0. This research aims to provide an understanding that the right curriculum for students will produce quality human resources in the era of globalization. Method: This research uses a qualitative approach with a literature study or literature review method. Data was collected by reviewing official sites such as Google Scholar, Research Gate, Public and Perish, and Sinta. Result: The results showed that implementing a curriculum relevant to the demands of the times is a must. The curriculum must reflect learners' needs and create creative, innovative, and competitive individuals. Novelty: This research offers new insight into implementing a school curriculum that supports enhancing students' digitalization capabilities in the Industry 4.0 era. In addition, this research also explores how curriculum can play a role in creating quality human resources. This research recommends that education should continue to be sensitive to the times and implement the curriculum according to the needs of current and future learners.