bluuebunny/crossref_metadata_2025_split huggingface dataset:
Videoradiographic analysis of how carbonated thin liquids and thickened liquids affect the physiology of swallowing in subjects with aspiration on thin liquids
Authors: Bülow M. , Olsson R. , Ekberg O. 
Published: December 2009

Purpose: To analyze how carbonated thin liquids affected the physiology of swallowing in dysphagic patients. Material and Methods: 40 patients were analyzed; 36 were neurologically impaired. During a therapeutic videoradiographic swallowing examination the patients had to swallow liquids with the following consistencies three times: thin, thickened and carbonated. The liquids were given in doses of 3 × 5 ml. The swallows were analyzed regarding penetration/aspiration, pharyngeal transit time and pharyngeal retention. Results: Significant difference was found regarding penetration/aspiration when comparisons were made between thin liquid and carbonated thin liquid ( p<0.0001). Carbonated liquid reduced the penetration to the airways. The comparison between thin liquid and thickened liquid ( p<0.0001) showed significant less penetration with thickened liquids. Pharyngeal transit time was reduced both when comparing thin liquid with thin carbonated liquid ( p<0.0001) and thickened liquid ( p<0.0001). Pharyngeal retention was significantly reduced ( p<0.0001) with carbonated thin liquid compared to thickened liquid. The comparison of thin liquids and carbonated thin liquids showed p = 0.0013, thin and thickened liquids p = 0.0097. Conclusions: Carbonated liquids reduced penetration/aspiration into the airways, reduced pharyngeal retention and pharyngeal transit time became shorter. Therefore, carbonated liquids are a valuable treatment option for patients with penetration/aspiration. Thickened liquids may still be an option for patients who cannot tolerate carbonated liquids and liquids with this consistency are safer than thin liquids.
Osteonecrosis diagnosed on MR images of the knee: Relationship to reduced bone mineral density determined by high resolution peripheral quantitative CT
Authors: Zanetti M. , Romero J. , Dambacher M. A. , Hodler J. 
Published: December 2009

Purpose: To evaluate if osteonecrosis diagnosed on MR images of the knee relates to reduced bone mineral density (BMD) and may be caused by an insufficiency fracture. Material and Methods: Thirty-two consecutive patients (8 men, 24 women; age range 27–82 years, mean 62 years) with MR findings of osteonecrosis of the femoral or tibial condyle were prospectively included. Trabecular and cortical BMD were measured with high resolution peripheral quantitative CT in the non-dominant distal radius and the tibia of the involved extremity. One tibia was not measured due to posttraumatic deformity. Results: The mean trabecular BMD of the radius was 81% of the young-adult average peak BMD (range 19–160%). The mean cortical BMD in the radius was 86% (range 63–108%). The mean trabecular BMD in the tibia was 92% (range 28–160%). The mean cortical BMD in the tibia was 86% (range 49–132%). The values of the trabecular bone of the distal radius (tibia) were normal in 11 (15) patients, osteopenic in 12 (4), and osteoporotic in 9 (12), respectively. The cortical bone values of the distal radius (tibia) were normal in 12 (13) patients, osteopenic in 12 (12), and osteoporotic in 8 (6), respectively. Conclusion: Osteoporosis and osteopenia are commonly found in patients with osteonecrosis of the knee as diagnosed on MR images. This indicates that for some patients an insufficiency mechanism may be responsible for the MR findings. However, in the patients with normal bone density other reasons for osteonecrosis may be present.
Intraductal papillary mucinous tumors of the pancreas
Authors: Fukukura Y. , Fujiyoshi F. , Hamada H. , Takao S. , Aikou T. , Hamada N. , Yonezawa S. , Nakajo M. 
Published: December 2009

Purpose: To compare the effectiveness of thin-section helical CT and MR imaging with gadolinium-enhanced dynamic technique and MR cholangiopancreatography (MRCP) in the examination of patients with intraductal papillary mucinous tumors. Material and Methods: Helical CT, dynamic MR imaging, and MRCP of 25 intraductal papillary mucinous tumors were compared with ERCP and surgical findings. Results: The duodenal papilla was identified by helical CT and dynamic MR imaging in 11 (44%) and 20 (80%) of the 25 patients, respectively ( p<0.05). The main pancreatic duct was visualized on helical CT, dynamic MR imaging, and MRCP in all patients (100%): 25 (96.2%), 24 (92.3%), and 26 (100%) cystic lesions were depicted, respectively. A communicating duct between the main pancreatic duct and the cystic lesion was visualized on helical CT, dynamic MR imaging, and MRCP in 14 (53.8%), 11 (42.3%), and 15 (55.7%) lesions, respectively. The papillary projections corresponding to 3 mm or larger papillary neoplasms were depicted on helical CT and MR imaging in 7 patients (25%). Conclusion: MR imaging was equal or slightly superior to thin-section helical CT in the evaluation of intraductal papillary mucinous tumors.
Effect of granulocyte colony-stimulating factor (G-CSF)-supported chemotherapy on MR imaging of normal red bone marrow in breast cancer patients with focal bone metastases
Authors: Çiray I. , Lindman H. , Åström G. K. O. , Wanders A. , Bergh J. , Ahlström H. K. 
Published: December 2009

Purpose: To investigate the effect of granulocyte colony-stimulating factor (G-CSF)-supported chemotherapy on normal red bone marrow MR imaging in breast cancer patients with focal bone metastases. Material and Methods: Fifteen breast cancer patients who were examined before and after chemotherapy with T1-weighted-SE and long echo-time inversion-recovery turbo-spin-echo (long TE IR-TSE) sequences in the thoracolumbar spine and pelvis were retrospectively studied. Nine of them received G-CSF therapy after the administration of each chemotherapy course. Of these 9 patients, the MR follow-ups were performed during G-CSF in 4 patients and after G-CSF therapy in 5 patients. Six patients did not receive G-CSF. Signal intensity (SI) changes in normal bone marrow were evaluated visually in all patients and quantitatively in 13 patients. Results: In all 4 patients investigated during G-CSF therapy a diffuse, homogeneous SI increase on long TE IR-TSE was observed visually and quantitatively in initially normal bone marrow. This change obscured some focal lesions in 2 patients. No such SI change was visible after G-CSF therapy ( p = 0.008) or in patients not receiving G-CSF. On T1-weighted images an SI decrease was found both during and after G-CSF therapy, but an increase occurred in patients not receiving G-CSF. Conclusion: G-CSF-supported chemotherapy can induce diffuse SI changes in normal red bone marrow on MR imaging. On long TE IR-TSE, the changes are visible during G-CSF treatment and can lead to misinterpretations in the response evaluation of bone metastases to therapy.
CellMC—a multiplatform model compiler for the Cell Broadband Engine and ×86
Authors: Caulfield Emmet , Hellander Andreas 
Published: December 2009

Abstract
Motivation: Gillespie's stochastic simulation algorithm (SSA) is often the most tractable method to study stochastic models of biochemical systems. The algorithm itself is very simple and a natural target for implementation on specialized architectures such as the Cell Broadband Engine (Cell/BE). We have developed CellMC, a multiplatform SBML model compiler implementing a vectorized version of SSA for use on Cell/BE or ×86 PCs.
Availability: The code is freely available from http://www.cellmc.org. It will run on a wide variety of ×86 computers running Linux/MacOSX (Darwin) and on Cell/BE computers such as the Sony PlayStation3 (PS3) and the IBM BladeCenter QS22. CellMC requires gcc, libxml2 and libxslt, all of which are installed by default on most of the supported platforms.
Contact: info@www.cellmc.org; andreas.hellander@it.uu.se
Supplementary information: Supplementary data are available at Bioinformatics online.
Antitumor activity of anti‐C‐ERC/mesothelin monoclonal antibody in vivo
Authors: Inami Koichi , Abe Masaaki , Takeda Kazuyoshi , Hagiwara Yoshiaki , Maeda Masahiro , Segawa Tatsuya , Suyama Masafumi , Watanabe Sumio , Hino Okio 
Published: December 2009

Mesothelioma is an aggressive cancer often caused by chronic asbestos exposure, and its prognosis is very poor despite the therapies currently used. Due to the long latency period between asbestos exposure and tumor development, the worldwide incidence will increase substantially in the next decades. Thus, novel effective therapies are warranted to improve the prognosis. The ERC/mesothelin gene (MSLN) is expressed in wide variety of human cancers, including mesotheliomas, and encodes a precursor protein cleaved by proteases to generate C‐ERC/mesothelin and N‐ERC/mesothelin. In this study, we investigated the antitumor activity of C‐ERC/mesothelin‐specific mouse monoclonal antibody, 22A31, against tumors derived from a human mesothelioma cell line, ACC‐MESO‐4, in a xenograft experimental model using female BALB/c athymic nude mice. Treatment with 22A31 did not inhibit cell proliferation of ACC‐MESO‐4 in vitro; however, therapeutic treatment with 22A31 drastically inhibited tumor growth in vivo. 22A31 induced antibody‐dependent cell‐mediated cytotoxicity by natural killer (NK) cells, but not macrophages, in vitro. Consistently, the F(ab′)2 fragment of 22A31 did not inhibit tumor growth in vivo, nor did it induce antibody‐dependent cell mediated cytotoxicity (ADCC) in vitro. Moreover, NK cell depletion diminished the antitumor effect of 22A31. Thus, 22A31 induced NK cell‐mediated ADCC and exerted antitumor activity in vivo. 22A31 could have potential as a therapeutic tool to treat C‐ERC/mesothelin‐expressing cancers including mesothelioma.(Cancer Sci 2010; 101: 969–974)
Association of human μ‐opioid receptor gene polymorphism A118G with fentanyl analgesia consumption in Chinese gynaecological patients
Authors: Zhang W. , Chang Y. Z. , Kan Q. C. , Zhang L. R. , Lu H. , Chu Q. J. , Wang Z. Y. , Li Z. S. , Zhang J. 
Published: December 2009

SummaryOne hundred and seventy‐four Chinese gynaecology patients were studied for the impact of A118G polymorphism in the μ‐opioid receptor gene (OPRM1) on pain sensitivity and postoperative fentanyl consumption. Pre‐operatively, the pain threshold and pain tolerance threshold were measured using electrical stimulation. A118G polymorphism was genotyped using the polymerase chain reaction–restriction fragment length polymorphism method. Intravenous fentanyl patient‐controlled analgesia provided postoperative pain management, assessed using a visual analogue scale and fentanyl consumed in the first 24 h after surgery was noted. We found the prevalence of G118 allele was 31.3%. The A118G polymorphism had a gene‐dose‐dependent effect on electrical pain tolerance threshold. Fentanyl consumption was also significantly different in patients with different OPRM1 genotypes (homozygotes for 118G consumed more than did heterozygotes or homozygotes for 118A). Fentanyl consumption increased in accordance with the number of 118G alleles. We conclude that OPRM1 gene analysis may help predict individual opioid sensitivity and so optimise postoperative pain control.
Effect of an episode of critical illness on subsequent hospitalisation: a linked data study
Authors: Williams T. A. , Knuiman M. W. , Finn J. C. , Ho K. M. , Dobb G. J. , Webb S. A. R. 
Published: December 2009

SummaryHealthcare utilisation can affect quality of life and is important in assessing the cost‐effectiveness of medical interventions. A clinical database was linked to two Australian state administrative databases to assess the difference in incidence of healthcare utilisation of 19 921 patients who survived their first episode of critical illness. The number of hospital admissions and days of hospitalisation per patient‐year was respectively 150% and 220% greater after than before an episode of critical illness (assessed over the same time period). This was the case regardless of age or type of surgery (i.e. cardiac vs non‐cardiac). After adjusting for the ageing effect of the cohort as a whole, there was still an unexplained two to four‐fold increase in hospital admissions per patient‐year after an episode of critical illness. We conclude that an episode of critical illness is a robust predictor of subsequent healthcare utilisation.
Dietary and fluid compliance: an educational intervention for patients having haemodialysis
Authors: Baraz Shahram , Parvardeh Siavash , Mohammadi Eissa , Broumand Behrouz 
Published: December 2009

baraz s.h., parvardeh s., mohammadi e. & broumand b. (2010) Dietary and fluid compliance: an educational intervention for patients having haemodialysis. Journal of Advanced Nursing66(1), 60–68.AbstractTitle.  Dietary and fluid compliance: an educational intervention for patients havinghaemodialysis.Aim.  This paper is a report of a study conducted to determine the effect of an educational intervention on dietary and fluid compliance in patients having haemodialysis.Background.  Many of the clinical problems experienced by patients having haemodialysis are related to their failure to eat appropriate foods and restrict their fluid intake. Educational intervention in patients having haemodialysis to improve their compliance with dietary and fluid restrictions appears to be effective.Methods.  Sixty‐three patients having haemodialysis in three general hospitals in Tehran, Iran, were allocated into two groups at random for oral and/or video education. They were asked to give demographic and medical data. Bimonthly average values of serum potassium, sodium, calcium, phosphate, albumin, creatinine, uric acid, and blood urea nitrogen and interdialytic weight gain were measured before and after the teaching programmes. The data were collected in 2007.Findings.  Compliance in terms of biochemical parameters and interdialytic weight gain was observed in 63·5% and 76·2% of patients in the oral and video teaching groups respectively. Statistically significant correlations were observed between demographic variables (age, educational level and occupation) and dietary and fluid compliances (P < 0·001). There was no difference between the effectiveness of two educational interventions.Conclusion.  Nurses should emphasize sodium compliance in patients having haemodialysis and explain its adverse effects, such as excessive weight gain, hypertension, and peripheral oedema.
Nurses’ knowledge of high‐alert medications: instrument development and validation
Authors: Hsaio Ghi‐Yin , Chen I‐Ju , Yu Shu , Wei Ien‐Lan , Fang Yu‐Yuan , Tang Fu‐In 
Published: December 2009

hsaio g.‐y., chen i.‐j., yu s., wei i.‐l., fang y.‐y. & tang f.‐i. (2010) Nurses’ knowledge of high‐alert medications: instrument development and validation. Journal of Advanced Nursing66(1), 177–190.AbstractTitle.  Nurses’ knowledge of high‐alert medications: instrument development andvalidation.Aim.  This paper is a report of the development and validation of an instrument to measure nurses’ knowledge of high‐alert medications and to analyse known administration errors.Background.  Insufficient knowledge is a factor in nurses’ drug administration errors. Most errors do not harm patients, but incorrect administration of high‐alert medications can result in serious consequences. Sufficient knowledge about high‐alert medications is vital.Method.  A cross‐sectional study was conducted in 2006 in Taiwan using a questionnaire developed from literature review and expert input, and validated by subject experts and two pilot studies. Section 1 of the questionnaire (20 true–false questions) evaluated nurses’ knowledge of high‐alert medications and section 2 was designed to analyse known administration errors. Snowball sampling and descriptive statistics were used.Findings.  A total of 305 nurses participated, giving a 79·2% response rate (305/385). The correct answer rate for section 1 was 56·5%, and nurses’ working experience contributed to scores. Only 3·6% of nurses considered themselves to have sufficient knowledge about high‐alert medications, 84·6% hoped to gain more training, and the leading obstacle reported was insufficient knowledge (75·4%). A total of 184 known administration errors were identified, including wrong drug (33·7%) and wrong dose (32·6%); 4·9% (nine cases; 9/184) resulted in serious consequences.Conclusion.  The questionnaire was valid and reliable. Evidence‐based results strongly suggest that nurses have insufficient knowledge about high‐alert medications and could benefit from additional education, particularly associated with intravenous bolus administration of high‐alert medications. Further research to validate the instrument is needed.
Coping with breast cancer: between diagnosis and surgery
Authors: Drageset Sigrunn , Lindstrøm Torill Christine , Underlid Kjell 
Published: December 2009

drageset s., lindstrøm t.c. & underlid k. (2010)  Coping with breast cancer: between diagnosis and surgery. Journal of Advanced Nursing66(1), 149–158.AbstractTitle.  Coping with breast cancer: between diagnosis and surgery.Aim.  This paper is a report of a descriptive study of coping strategies used by women between diagnosis of breast cancer and surgery.Background.  Although research has suggested that the initial phase of breast cancer is important in the overall process of coping, there have been few qualitative studies conducted in the period between diagnosis and surgery to describe women’s experiences and coping efforts in the midst of stress.Method.  Individual interviews were conducted with 21 women with newly diagnosed breast cancer who were awaiting surgery. Data were collected from February 2006 to February 2007 at a Norwegian university hospital. Transcripts were analysed using methods of qualitative content analysis.Findings.  Prominent themes about coping between diagnosis and surgery were: step‐by‐step, pushing away, business as usual, enjoying life, dealing with emotions, preparing for the worst and positive focus. The women were highly aware of the threat of death, but at the same time hopeful and optimistic. In general, they wanted to be treated as usual. Pity and compassion could increase their feelings of fear and vulnerability. Emotions were dealt with either by openness or by holding back.Conclusion.  Avoiding being overwhelmed by emotional reactions was a major goal for the women. Their coping strategies displayed similar patterns but diverged on some points. In general they needed to manage the situation in their own way. By being aware of women’s individual needs and different coping strategies, nurses and other healthcare professionals can improve support to women in this vulnerable situation.
Procedural discourse in intellectual disability and dual diagnosis
Authors: Ryan J. , Woodyatt G. , Copeland D. 
Published: December 2009

AbstractBackground  Knowledge of discourse abilities of adults with intellectual disability (ID) and mental illness is limited. The present study examined the procedural discourse skills of two cohorts of adults with ID – one cohort with (n = 7) and one cohort without (n = 7) a psychiatric diagnosis of psychosis.Methods  Participants completed the ‘dice game’, a procedural discourse elicitation procedure that has been used by previous researchers.Results  Results revealed that while all participants demonstrated an understanding of the task, participants with ID alone were more able to communicate the key elements of the game than the participants in the dual diagnosis group.Conclusions  Results of this investigation suggest that individuals with dual diagnosis have difficulties that may relate to previously identified discourse impairments in people with schizophrenia, and this may relate to a larger difficulty in taking into account the listener's needs.
Emotional and behavioural problems in adolescents with intellectual disability with and without chronic diseases
Authors: Oeseburg B. , Jansen D. E. M. C. , Groothoff J. W. , Dijkstra G. J. , Reijneveld S. A. 
Published: December 2009

AbstractBackground  Adolescents with intellectual disability (ID) (ID‐adolescents) and adolescents with chronic diseases are both more likely to have emotional and behavioural problems. The aim of this study was to assess the association between chronic diseases in ID‐adolescents and emotional and behavioural problems in a large school‐based sample.Methods  We obtained data on 1044 ID‐adolescents, aged 12–18 years, attending secondary schools in the Netherlands. Parents of the adolescents completed the Dutch version of the Strengths and Difficulties Questionnaire and questions about chronic diseases in their child and about the background of the child.Results  Prevalence rates of emotional and behavioural problems were generally high in ID‐adolescents with chronic diseases (45%), compared with ID‐adolescents without chronic diseases (17%). The likelihood of emotional and behavioural problems was high in ID‐adolescents with two [odds ratios (OR) 4.47; 95% CI: 2.97–6.74] or more than two chronic diseases (OR 8.01; 95% CI: 5.18–12.39) and for ID‐adolescents with mental chronic diseases (OR 4.56; 95% CI: 3.21–6.47). Also ID‐adolescents with somatic chronic diseases had a high likelihood of emotional and behavioural problems (OR 1.99; 95% CI: 1.33–2.99), in particular in the combination of somatic and mental chronic diseases (OR 5.16; 95% CI: 3.46–7.71).Conclusions  The current study showed that chronic diseases in ID‐adolescents, in particular mental chronic diseases, largely increase the likelihood of emotional and behavioural problems. This should be taken in the provision and planning of care for ID‐adolescents.
Maternal diet during pregnancy and allergic sensitization in the offspring by 5 yrs of age:  a prospective cohort study
Authors: Nwaru Bright I. , Ahonen Suvi , Kaila Minna , Erkkola Maijaliisa , Haapala Anna‐Maija , Kronberg‐Kippilä Carina , Veijola Riitta , Ilonen Jorma , Simell Olli , Knip Mikael , Virtanen Suvi M. 
Published: December 2009

Nwaru BI, Ahonen S, Kaila M, Erkkola M, Haapala A‐M, Kronberg‐Kippilä C, Veijola R, Ilonen J, Simell O, Knip M, Virtanen SM. Maternal diet during pregnancy and allergic sensitization in the offspring by 5 yrs of age: a prospective cohort study. Pediatr Allergy Immunol 2010: 21: 29–37. © 2009 John Wiley & Sons A/STo examine the effect of maternal diet during pregnancy on allergic sensitization in the offspring by 5 yrs of age. The Finnish type 1 Diabetes Prediction and Prevention Nutrition Study. A population‐based cohort study with 5‐yr follow‐up. A total of 931 children with human leukocyte antigen‐conferred susceptibility to type 1 diabetes for whom maternal pregnancy food frequency questionnaire data and allergen‐specific immunoglobulin E measurement at 5 yrs were available. Increasing maternal consumption of citrus fruits [odds ratio (OR) = 1.14, 95% confidence interval (CI) = 1.05–1.25] and total fruit (OR = 1.36, 95% CI = 1.09–1.70) were positively associated with sensitization to inhalant allergens, after adjustment for potential confounders. Maternal intake of vitamin D (OR = 0.56, 95% CI = 0.35–0.91) was inversely associated with sensitization to food allergens. Maternal consumption of citrus fruits during pregnancy may increase the risk to allergic sensitization in the offspring, whereas vitamin D intake may have a beneficial effect. Further studies are required to define more closely the putative effect of maternal intake of polyunsaturated fatty acids on development of allergic diseases in the offspring.