bluuebunny/crossref_metadata_2025_split huggingface dataset:
The oncogenic potential of salivary microRNA-93 and microRNA-412-3p in oral lichen planus: A Case-Control Study
Authors: ELhefny Moataz , Rashwan Weam , Shaker Olfat , Korien Inas 
Published: June 2024

Abstract

Background: Oral Lichen Planus is one of the most popular chronic mucocutaneous diseases. It is classified as potentially malignant lesions. Many microRNAs can be used as biological markers for the disease and for its malignant transformation. The aim of the study to measure the expression of microRNA-93 and microRNA-412-3p in Oral Lichen Planus patients, patients diagnosed as Oral Squamous Cell Carcinoma and healthy controls.
Methodology: 60 patients were divided into 3 groups; each group contains 20 patients. Group I for Oral Lichen Planus patients, group II for healthy controls and group III for Oral Squamous cell carcinoma patients. All of these patients were chosen from those attending Kasr Al-Einy hospital, Cairo University. After full diagnosis and matching of our eligibility criteria, saliva sample was taken from each patient to measure the concentration of microRNA-93 and microRNA-412-3p. Results: Both microRNA-93 and miceoRNA-412-3p were upregulated in Oral Squamous cell carcinoma patients than Oral Lichen patients than controls and both of them had great sensitivity, specificity and diagnostic accuracy for both Oral Lichen Planus and Oral Squamous cell carcinoma.
Conclusion: MicroRNA-93 and micriRNA-412-3p can be used as diagnostic markers and for the oncogenic potential of Oral Lichen Planus Key Words OLP, OSCC, microRNA, miRNA-93, miRNA-412-3p
Impact of High-Protein Diets on Weight Loss Programs: Analyzing Loss of Muscle and Skeletal Mass
Authors: Ma Yahui , Sun Lina , Mu Zhijing 
Published: June 2024

Abstract

Objective
The objective of this probe is to determine the effects of High-Protein Diets (HPD) on weight loss programs.
Methodology
From January 2021 to May 2022, 133 patients, who were enrolled in a Chinese-based weight loss program, participated in a clinical trial aimed at investigating the impact of High-Protein Diets (HPD) on weight loss programs. The effects of the diet plan on the patients’ insulin, hemoglobin, and Vitamin D levels were assessed and the findings examined to evaluate the impact of HPD on muscle and skeletal mass.
Results and Findings
HPD was useful in catalyzing the effectiveness of weight loss programs. It led to reductions in skeletal and muscle mass during the trial period based on its impact on insulin, hemoglobin, and Vitamin D levels among the trial population..
Osteopathic management of non-specific neck pain: a modified Delphi study
Authors: Fleischmann Michael , McLaughlin Patrick , Vaughan Brett , Hayes Alan 
Published: June 2024

Abstract

Background
Neck pain is a widespread and persistent musculoskeletal condition, with over half of cases unresolved for years. Nonspecific neck pain poses a particular challenge, often driven by complex physical, psychological, and social factors that lead to ongoing disability. Osteopaths frequently treat musculoskeletal pain using a biopsychosocial approach, yet their specific strategies for nonspecific neck pain remain largely unexplored and likely vary based on practitioner approach.
Methods
Eleven osteopaths took part in a modified Delphi involving the completion of successive online questionnaires. Across three distinct rounds, participants responded to three different questionnaires distributed via email. Survey development was based on HOAC-II, a patient centred framework for healthcare. Surveys comprised questions related to frequency of use of various osteopathic examination, treatment and management techniques and strategies for patients with nonspecific neck pain. Round 1 and Round 2 comprised open ended questions, Round 3 sought an agreement (Kendall’s W) from panel members about what examination, treatment techniques and management approaches are essential for patients with nonspecific neck pain.
Results
This modified Delphi study established a consensus among expert osteopaths regarding the examination and management of patients with NSNP. Employing the patient-centred HOAC-II framework, the study highlighted key elements of NSNP care deemed essential by Australian osteopaths.
Conclusion
The study revealed that the examination techniques and management strategies osteopaths consider essential for patients with non-specific neck pain align with practices frequently used by other health professionals.
Preliminary Diagnostic Assessment Process and Case Studies for Existing Residential Regeneration
Authors: Liu Chang , Fan Yue , Zhang Qiong , Lin Guanfeng 
Published: June 2024

Abstract

With the increasing efforts of the state to renew old settlements, the regeneration of existing houses built in the 1980s-2000s has entered a stage where it is urgent to transform from rough to refined transformation, but the diagnostic and assessment standards and decision-making basis for the pre-transformation stage have not yet been established. At the same time, the arrival of the era of informatization and intelligence also brings new opportunities and challenges for the diagnostic and assessment work of existing residential regeneration. Based on the existing research foundation of building regeneration, the article constructs a diagnostic and assessment process for the regeneration of existing residential buildings from an architectural perspective, which is divided into three phases: data collection and integration, visual model construction, and diagnostic assessment and analysis, and comprehensively applies the technology of building information modeling to carry out a comprehensive assessment using qualitative and quantitative diagnosis to form the template of diagnostic assessment. The diagnostic assessment template is formed, and an existing residence in Shenzhen is used as a case study object to apply the diagnostic assessment methodology and process, covering the collection of key element information, integration, diagnosis, and further assessment based on the diagnostic conclusions, to guide the design of remodeling programs. The study provides scientific guidance and decision-making direction for the practice of fine regeneration of existing residences and the formulation of related standard guidelines, improves the efficiency of decision-making, and has advanced demonstrative effect and foresight.
Development mechanisms of cyclonic vorticity under two distinct large-scale weather patterns associated with summer heavy rainfall over North China
Authors: Li Jiao , Zhao Ping , Chen Deliang , Zhao Yang , Wen Zhiping , Zhang Chao 
Published: June 2024

Abstract

Two types of weather patterns with distinct locations of low-level cyclonic vorticity anomaly, referred to as Type 1 and Type 2, associated with local heavy summer rainfall over North China have been identified (Li et al., 2024). However, their evolutions and underlying mechanisms were not investigated. In this present study, we find that the large positive value of vorticity anomalies (LPV) of both types exhibit eastward intensification from their early to developing stages. Nonetheless, they follow distinct trajectories. Type 1 takes a northern path, while Type 2 follows a southern trajectory. These distinct LPV trajectories are primarily attributed to synoptic-scale circulations. Type 1 is influenced by the northward shift of the Western North Pacific subtropical high (WNPSH), while Type 2 is affected by both the southward shift of WNPSH and baroclinic trough. Despite the varied paths, the LPVs for both types share eastward development, significantly linked to vertical motion stretching. Quantitative examinations reveal that the dynamic forcing mainly driven by temperature advection dominates vertical motion for Type 1 at the early stage, contributing 66.4%. In contrast, for Type 2, the diabatic forcing plays a more significant role, accounting for 59.7%. The underlying mechanism for Type 1 involves significant southerly wind anomalies transporting warm flows northwards, promoting strong warm advection and enhancing upward motion and LPV development. For Type 2, abundant moisture near the LPV facilitates strong diabatic forcing-induced upward motion. By the developing stage, the diabatic forcing becomes the main driver of vertical motion for both types.
Optimizing nitrogen fertilizer for improved root growth, nitrogen utilization, and yield of cotton under mulched drip irrigation in southern Xinjiang, China
Authors: luo yu , Yin Hao , Ma Yue , Wang Juanhong , Che Qingxuan , Zhang Man , Chen Bolang , Feng Gu 
Published: June 2024

Abstract

The root system plays a crucial role in water and nutrient absorption, making it a significant factor affected by nitrogen (N) availability in the soil. However, the intricate dynamics and distribution patterns of cotton (Gossypium hirsutum L.) root density and N nutrient under varying N supplies in Southern Xinjiang, China, have not been thoroughly understood. A two-year experiment (2021 and 2022) was conducted to determine the effects of five N rates (0, 150, 225, 300, and 450 kg N ha− 1) on the root system, shoot growth, N uptake and distribution, and cotton yield. Compared to the N0 treatment (0 kg N ha− 1), the application of N fertilizer at a rate of 300 kg N ha− 1 resulted in consistent and higher seed cotton yields of 5875 kg ha− 1 and 6815 kg ha− 1 in 2021 and 2022, respectively. This N fertilization also led to a significant improvement in dry matter weight and N uptake by 32.4% and 53.7%, respectively. Furthermore, applying N fertilizer at a rate of 225 kg N ha− 1 significantly increased root length density (RLD), root surface density (RSD), and root volume density (RVD) by 49.6-113.3%, 29.1–95.1%, and 42.2–64.4%, respectively, compared to the treatment without N fertilization (0 kg N ha− 1). Notably, the roots in the 0-20cm soil layers exhibited a stronger response to N fertilization compared to the roots distributed in the 20-40cm soil layers. The root morphology parameters (RLD, RSD, and RVD) at specific soil depths (0–10 cm in the seedling stage, 10–25 cm in the bud stage, and 20–40 cm in the peak boll stage) were significantly associated with N uptake and seed cotton yield. Optimizing nitrogen fertilizer supply within the range of 225–300 kg N ha− 1 can enhance root foraging, thereby promoting the interaction between roots and shoots and ultimately improving cotton production in arid areas.
Intraocular pressure lowering effect of Omidenepag Isopropyl in Glaucoma: Comparing between Normal-Tension Glaucoma and Primary Open-Angle Glaucoma
Authors: Ryu Hee Kyung , Kim Seong Ah , Shin Hee Jong , Oh Si Eun , Park Chan Kee , Park Hae-Young Lopilly 
Published: June 2024

Abstract

The purpose of this study is to investigate factors influencing the efficacy of Omidenepag Isopropyl (OMDI) in reducing intraocular pressure (IOP), and to compare its effects between patients with normal-tension glaucoma (NTG) and those with primary open-angle glaucoma (POAG). Eyes treated with OMDI, including 48 with NTG and 46 with POAG, were included. Data on visual acuity (VA), IOP, central corneal thickness (CCT), axial length (AxL), mean deviation (MD), visual field index (VFI), and retinal nerve fiber layer (RNFL) thickness were collected. Differences across groups (NTG vs. POAG, OMDI responders vs. non-responders, and HM(High myopia) vs. non-HM) were evaluated using independent t-tests for factors. Linear regression was used to identify factors associated with the IOP reduction efficacy of OMDI within the NTG and POAG groups. ANCOVA assessed mean IOP reduction differences between groups adjusting for other significant variables. In NTG patients, a negative correlation was observed between AxL with the IOP reduction effect of OMDI, while a positive correlation between baseline IOP and VA reduction with the percentage of IOP reduction was noted in both NTG and POAG groups. There was a trend toward greater IOP reduction effect by OMDI in NTG compared to POAG after adjusting for baseline IOP and AxL. In the NTG group, HM eyes showed a lower IOP reduction rate compared to non-HM eyes, following adjustments for baseline IOP.
Prevalence and factors associated with self-medication among physicians in selected Hospitals of Addis Ababa, Ethiopia: A Cross-Sectional study
Authors: Tefera Dawit Bekele , Gebreegziabher Mahlet Arkebe , Mamo Biniyam Tedla , Adem Abebawork Getachew , Azerefegn Ewnet Ferdu , Wodabo Bezawit Wondimu , Abebaw Tsega-ab 
Published: June 2024

Abstract

Background: Self-medication is the selection and use of medications to manage self-diagnosed illnesses or symptoms. It often doesn’t properly cure illnesses rather has added risks including iatrogenic diseases, masking of developing diseases, poisonings, adverse reactions, and development of resistance. Despite this, there is a lack of comprehensive data on self-medication among physicians in Ethiopia.
Aim: To assess the prevalence and factors associated with self-medication, among physicians in selected hospitals of Addis Ababa.
Study setting and Methods: An institutional-based cross-sectional study was conducted, in four governmental hospitals in Addis Ababa. A total of 447 physcian has participated in the study. Descriptive statistics were used to describe study variables. Additionally, bivariable and multivariable logistic regression analyses were used to identify factors associated with self-medication. A P- value< 0.05 was set to declare statistical significance.
Results: The prevalence of self-medication among physicians was 262 [58.3% ( 95%, CI 53.9-63.2)] in a 3-month recall period. The most common reasons were saving time 60.3%, taking self-medication as a norm 51%, high cost of paraclinical services 70.5% and poor quality of service at health facility 73.6%. The odds of practicing self-medication were nearly two times higher among physicians on specialty training program (resident physcians) than those who are full time employees in the hospitals,(AOR 1.70, 95% CI:1.10- 2.60).
Conclusion: The study revealed a high prevalence of self-medication practice and physicians on specialty training program were more prone to self-medicate. This association suggests the importance of addressing the problem within teaching hospitals
Incidence and prevalence of hepatitis C and B infections among men who have sex with men and transgender women enrolled in a United States HIV vaccine trial
Authors: Scherer Matthew , Nandi Vijay , Sobieszczyk Magdalena E , Laeyendecker Oliver , Karuna Shelly , Andrasik Michele , Janes Holly E , Brown Erin E , Tieu Hong-Van 
Published: June 2024

Abstract

Background:
Rising hepatitis C and B virus (HCV and HBV) rates have been reported in men who have sex with men (MSM) and transgender women (TGW). This study characterizes HCV and HBV infections longitudinally among 2,496 MSM/TGW aged 18–50 years and at risk for HIV acquisition enrolled in an HIV-1 vaccine trial in 18 U.S. cities between 2009–2013.
Methods:
Participants completed behavioral surveys, HIV testing, and blood collection over 24 months. Of the 2,397 participants who consented for future testing, 1,792 (74.8%) had available paired stored blood samples at baseline and a later timepoint (Month 24 [N = 999]; if unavailable, M12 [N = 775] or M15 [N = 18]).
Results:
Among 1,792 participants, 98.1% were MSM, 0.8% were TGW, and the median age was 30 years (IQR 24, 40). Participants reported a median number of 3 male sex partners (IQR 1,5) within the past 3 months. Condomless insertive anal sex was reported by 55.8% and condomless receptive anal sex by 46.7%. 1.3% reported injection drug use. During follow-up, 1.4% reported pre-exposure prophylaxis (PrEP) use. At baseline 11/1792 (0.61%) participants had HCV infection (HCV AB positive, RNA detectable), with all having persistent detectable RNA and chronic HCV infection at follow-up. Phylogenetic analysis showed no clusters of HCV infection. 8 participants had HCV AB positive, RNA undetectable at baseline and follow-up, representing past HCV infection with clearance; only 2 acquired HCV, which cleared over 12–24 months. At baseline, 2 participants (2/1792 = 0.11%) had positive HBsAg, indicating chronic HBV infection. Over 12–24 months, 4 (4/1790, 0.22%) developed HBsAg positivity; these participants had HBcAB positivity at baseline, thereby likely representing reactivation. There were no new HBV infections during follow-up.
Conclusion:
Among 1,792 men who have sex with men and transgender women aged 18–50 years and at risk for HIV acquisition enrolled in a U.S. HIV-1 vaccine trial, incident hepatitis C infection rates were extremely low, with no cases of incident hepatitis B infection. These rates of incident HCV infection and HBSAg positivity are lower than previously reported among MSM/TGW.
Circulating prolactin levels and the effect of dopaminergic agonists in systemic lupus erythematosus: a systematic review and meta-analysis
Authors: Santos Álida Alves dos , de Castro Lucas Faria , de Lima Caroline Lourenço , Motta Lucilia Domingues Casulari da , Motta Luiz Augusto Casulari Roxo da , Amato Angélica 
Published: June 2024

Abstract

This systematic review of clinical studies investigated whether circulating PRL levels differed between subjects with systemic lupus erythematosus (SLE) and healthy controls, the correlation between circulating PRL and SLE activity, and the effect of dopaminergic agonists as adjuvant therapy for SLE. We searched PubMed, Scopus, Web of Science, Cochrane, Embase, and Google Scholar for case-control and cross-sectional studies investigating circulating PRL levels in subjects with SLE and/or its correlation with disease activity, and clinical trials examining the effect of dopaminergic agonists on SLE activity assessed by the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) score. Forty-five studies addressing circulating PRL levels in SLE met our inclusion criteria. SLE was associated with an increased odds of hyperprolactinemia (OR 11.69, 95%CI 5.64–24.22) and circulating PRL levels were significantly higher in subjects with SLE than in controls (standardized mean difference of 1.96, 95%CI 1.27–2.65). Circulating PRL was positively correlated with SLE activity assessed by the SLEDAI (correlation coefficient 0.38, 95% CI 0.26–0.48). Two randomized clinical trials with bromocriptine and three prospective open-label trials with quinagolide reported that treatment with dopaminergic agonists was associated with reduced frequency of disease flare and decreased SLEDAI score. Circulating PRL levels were higher in subjects with SLE than in healthy controls and are significantly associated with disease activity. In addition, treatment with the dopaminergic agonists bromocriptine and quinagolide reduced SLE disease activity and may be a beneficial adjuvant therapy for the disease. This review was registered in PROSPERO (CRD42021237156).
The economic burden of prostate cancer in Iran
Authors: Teli Banafshe Darvishi , Rezapour Aziz , Behzadifar Meysam , Azari Samad , Ehsanzadeh Seyed Jafar , Behzadifar Masoud 
Published: June 2024

Abstract

Objective
This study aims to assess the economic burden of prostate cancer in Iran by analyzing direct medical costs, direct non-medical costs, indirect costs, and out-of-pocket expenses associated with the disease. We conducted a cross-sectional cost-of-illness study in Khorramabad, located in western Iran, during 2023, using a prevalence-based, bottom-up approach. Data were collected from 285 prostate cancer patients at Rahimi Hospital through questionnaires, interviews, and patient records.
Results
Our study revealed that the total economic burden of prostate cancer amounted to $230,565, with an average cost of $809 per patient. Direct medical costs constituted 74% of the total burden, totaling $169,860, with therapy costs being the most significant component. Direct non-medical costs reached $13,395, while indirect costs due to productivity losses were estimated at $25,935. Out-of-pocket expenses accounted for $21,375, representing 9% of the overall costs. The substantial direct medical expenses underscore the considerable financial strain on both the healthcare system and patients. Prostate cancer imposes a significant economic burden in Iran, underscoring the urgency of enhancing insurance coverage and implementing early detection strategies to mitigate its financial impact. Standardized cost analysis methodologies and improved financial protection mechanisms are essential for alleviating the economic strain on patients and the healthcare system.
Evaluating the Progress and Challenges of Environmental Sustainability in the Nigerian Construction Industry: A Comprehensive Literature Review
Authors: Unegbu H. C. O. , Yawas D. S. , Dan-asabe B. , Alabi A. A. 
Published: June 2024

Abstract

This article presents a comprehensive literature review of sustainable construction practices in Nigeria, examining the progress, challenges, and opportunities within the sector over the past two decades. Through a systematic review of scholarly articles, this study identifies significant advancements in technological innovations and policy development aimed at promoting sustainability in the construction industry. However, the review also highlights persistent barriers that hinder broader adoption, including economic constraints, cultural resistance, and regulatory challenges. The findings reveal a growing trend towards the adoption of sustainable technologies and materials, supported by evolving governmental policies. Despite these positive developments, the high costs associated with green technologies, cultural preferences for traditional construction methods, and inconsistent regulatory enforcement remain substantial obstacles. The review employs a mixed-methods approach, combining qualitative and quantitative analyses to provide a nuanced understanding of the dynamics at play. Based on the results, the study offers recommendations for future research, emphasizing the need for economic analyses of sustainability investments, cultural studies on construction practices, comparative international studies, and longitudinal research to track policy effectiveness.
Enteral Nutrition vs Parenteral Nutrition in the Management of Postoperative Pancreatic Fistula Following Pancreaticoduodenectomy : A Prospective Observational Study
Authors: Kodali Rohith , Parasar Kunal , Anand Utpal , Singh Basant Narayan , Kant Kislay , Anwar Saad , saha Bijit 
Published: June 2024

Abstract

Purpose: Postoperative pancreatic fistula (POPF) poses a challenge to oral intake after Pancreaticoduodenectomy (PD). Various strategies such as enteral feeding via nasojejunal tube, feeding jejunostomy (FJ), and total parenteral nutrition , are employed to enhance postoperative nutrition. The routine adoption of FJ in PD remains a debatable topic. This study aims to assess and compare the efficacy of enteral feeding and parenteral nutrition in the management of POPF.
Material and methods: Seventy patients who underwent classical PD at a tertiary care center in east India between July 2019 and December 2023 were randomly allocated to FJ and non-FJ in 1:1 ratio. The primary end point was procedure related complications (POPF, delayed gastric emptying, post pancreatectomy hemorrhage , bile leak, Clavien Dindo grade ³3), length of hospital stay,additional costs, 30-day mortality and tube-related complications.
Results: Out of 70 patients who underwent PD 35 received FJ as part of the standard care while the remaining 35 patients with no FJ. The majority of POPF cases were Grade B (40 vs 31.4%). Patients with Grade B POPF who underwent routine FJ placement exhibited shorter fistula durations (3.9 vs. 5.2 weeks, p< 0.001) and reduced intraabdominal drain durations (26.4 vs. 34.9 days, p<0.001). No differences were observed in the incidence of complications , reoperation, length of hospital stay readmission and 30-day mortality. No adverse complications were associated with FJ placement.
Conclusion: For PD patients requiring prolonged postoperative nutritional support due to POPF and DGE, routine FJ can be a safe and cost-effective approach.