bluuebunny/crossref_metadata_2025_split huggingface dataset:
Muon beamtest results of high-density glass scintillator tiles
Authors: Du Dejing , Liu Yong , Cai Hua , Chen Danping , Hua Zhehao , Han Jifeng , Liu Shan , Qi Baohua , Qian Sen , Ren Jing , Sun Xinyuan , Tang Gao , Yang Dong , Yin Shenghua , Zhang Minghui 
Published: May 2024

Abstract
To achieve the physics goal of precisely measure the Higgs,
Z, W bosons and the top quark, future electron-positron colliders
require that their detector system has excellent jet energy
resolution. One feasible technical option is the high granular
calorimetery based on the particle flow algorithm (PFA). A new
high-granularity hadronic calorimeter with glass scintillator tiles
(GSHCAL) has been proposed, which focus on the significant
improvement of hadronic energy resolution with a notable increase of
the energy sampling fraction by using high-density glass
scintillator tiles. The minimum ionizing particle (MIP) response of
a glass scintillator tile is crucial to the hadronic calorimeter, so
a dedicated beamtest setup was developed for testing the first batch
of large-size glass scintillators. The maximum MIP response of the
first batch of glass scintillator tiles can reach up to 107
p.e./MIP, which essentially meets the design requirements of the
CEPC GSHCAL. An optical simulation model of a single glass
scintillator tile has been established, and the simulation results
are consistent with the beamtest results.
The novel equipment for measuring internal stress in acrylic
Authors: Yang Xiaoyu , Heng Yuekun , Chen Zhiqiang , Wei Cunfeng , Zhang Zhiming , Wei Long 
Published: May 2024

Abstract
Acrylic is widely used in aquariums, windows of planes and
submarines, and even scientific experiments like the Sudbury
Neutrino Observatory (SNO) and the Jiangmen Underground Neutrino
Observatory (JUNO). Internal stress has a significant impact on the
properties and characteristics of acrylic such as strength, fracture
and creep, which is highly concerned and has become a hotspot in
research field. The measurement of internal stress is an important
issue, which includes two aspects - the calibration of
stress-optical coefficient of acrylic and the measurement of
birefringence optical path difference (BOPD) caused by internal
stress. The measuring equipment mainly realize the measurement of
BOPD, and currently have the largest dynamic range of
50–3000 nm. Dynamic range is considered as one of the core
performance indicators of measuring equipment, and a larger dynamic
range is urgently required to meet the needs of different
scenarios. The novel equipment for measuring internal stress in
acrylic has been designed and developed based on photo-elastic
principle and spectrometric method, which has the dynamic range of
20–12000 nm and the uncertainty of stress measurement better than
3%. The measuring principle, components, functions and measurements
of the novel measuring equipment are introduced and discussed in
this article.
The engineering face-lift of the 32m dish: technical upgrades of Ghana Radio Astronomy Observatory (GRAO)
Authors: Nsor J.A.K. , Ansah-Narh T. , Proven-Adzri E. , Koranteng-Acquah J. , Mornoh E.K. 
Published: May 2024

Abstract
Ghana's 32-meter radio telescope, inaugurated in August 2017, was once a redundant
telecommunications dish that underwent conversion. Prior to this transformation, feasibility
studies were conducted to assess the dish's structural integrity, technical compatibility, and
economic viability. These studies aimed to determine if the conversion project could be
technically achieved given the available technology, expertise, and resources. This paper delves
into the engineering considerations surrounding structural, mechanical, software, control and
monitoring, radio frequency, and timing frequency reference requirements that distinguish the
operation of a radio telescope from its former role as a satellite earth station. Significant
components such as the azimuth bearing, sub-reflector support, cable wrap, and electrical motors
underwent replacement. Additionally, a new C-band receiver, radio frequency controller, active
hydrogen maser timing frequency, and software were developed. Testing protocols to meet science
requirements for both single-dish observations and Very Long Baseline Interferometry (VLBI) are
also discussed. The conversion process proved to be lengthy and encountered numerous unforeseen
circumstances, yet it provided invaluable learning experiences for a developing country
like Ghana.
Lattice eigenfunction equations of KdV-type
*
Authors: Wu Xiaoyan , Zhang Cheng , Zhang Da-jun , Zhang Haifei 
Published: May 2024

Abstract
We develop lattice eigenfunction equations of the lattice KdV equation, which are equations obeyed by auxiliary functions, or eigenfunctions, of the Lax pair of the lattice KdV equation. These equations are three-dimensionally consistent quad-equations, that are closely related to lattice equations in the Adler-Bobenko-Suris (ABS) classification. The connection between the H3(δ), Q1(δ), Q2 and Q3(δ) equations in the ABS classification and the lattice eigenfunction equations is explicitly showed. In particular, we provide a natural interpretation of the δ term in those equations. This can be understood as ‘interactions’ between the eigenfunctions. Other integrable properties of the eigenfunction equations, such as exact solutions, discrete zero curvature conditions are also provided. We believe that the approach presented in this paper can be used as a means to search for integrable lattice equations.>
Designation of a maritime conservation area in the waters of Haruku-Sameth, Central Maluku Regency
Authors: Abrahamsz James , Makailipessy M M 
Published: May 2024

Abstract
Two traditional villages in the Central Maluku Regency are called Haruku-Samet. They have unique historical and ecological potential, as well as being locations for traditional ceremonies and historical maritime landmarks. The potential exists for development as a marine conservation area. The study’s objectives are to evaluate and identify the type of designated maritime conservation area. The study was carried out from April through October 2020. Data on the species and density of seagrass and mangroves, as well as the percentage of coral reef cover, were gathered by surveys and observations. Community organizations and fishermen participated in participatory mapping, interviews, and discussions to gather data on the potential and uses of coastal and marine resources. Mangrove, seagrass, and coral reef habitat distribution was determined by field surveys, with supported by an examination of Landsat 8 imagery. In compliance with the E-KKP3K Supplement Guidelines (Supplement 1), 20 assessment indicators are analyzed for the identification, inventory, and reserve of Maritime Conservation Areas. According to the results, the candidate for the traditional marine conservation area of the Haruku-Sameth villages was deemed highly suitable for development as a conservation area under the category of Maritime Conservation Area, specifically classified as a Maritime Indigenous Protection Area.
The Potency of Antibacterial Activity of Avicennia officinalis Leaf Extract Originating from Ambon Bay, Maluku, Indonesia
Authors: Bonan Dolok Sormin Raja , Nelce Mailoa Meigy , Nendissa Dessire M , Krisanta Enda Savitri Imelda , Nanlohy Esterlina E.E.M. , Matulessy Paul 
Published: May 2024

Abstract
Mangroves are known as perennial plants that thrive and adapt in tropical coastal areas affected by tidal cycles. Mangroves serve ecological functions such as protecting the coast from wind, currents, and sea waves. Besides its ecological functions, mangrove leaf known well has an activity as antibacterial. The objective of this study was to determine the yield, phytochemical component contained and antibacterial strength of Avicennia officinalis leaf extract, originating from Ambon Bay against Staphylococcus aureus and Escherichia coli. The result showed that Avicennia officinalis leave extracts methanol extract generated an inhibition zone 14.97±0.41 mm against Staphylococcus aureus and 12.01±0.06 mm against Escherichia coli. Methanol solvent exhibits the highest antibacterial activity against Staphylococcus aureus, followed by ethyl acetate and n-hexane extracts. However, Escherichia coli showed more resistance to the Avicennia officinalis leaf extract.
Outer Space Treaty and Fundamental Principles
Authors: Aoki Setsuko 
Published: May 2024

Abstract
The Outer Space Treaty (OST) is the most important treaty relating to space activities. It reflected fundamental principles of international space law when it was adopted in 1966 and has been the basis of the subsequently developed rules and frameworks for space activities. This chapter analyses the implications of the major principles of the OST with some reference to subsequent developments of corresponding principles. These include: (i) the legal status of the exploration and use of outer space (balance of the common interests of all countries and the freedom of exploration and use as well as non-appropriation, including the issue of space resources exploitation); and (ii) peaceful uses of outer space. This involves the permissible scope of military uses in outer void space and on celestial bodies, which could depend on the interpretation of ‘peaceful’ equating with ‘non-military’ or ‘non-aggressive’ as well as the legal implication of ‘exclusively’.
Registration of Space Objects
Authors: Hofmann Mahulena 
Published: May 2024

Abstract
The registration of space objects is an important trust-building measure. The idea of registering spacecraft was inspired by the long-standing praxis of registration of ships and aircraft. The primary objective of the present international registration of space objects is their identification. In international and national space law, the registration of a space object is a significant fact which has important legal consequences. It creates a chain of attribution between the launching State, the space object, international responsibility for space activities and jurisdiction and control by the registering State. At the national level, the registration of a space object in the national registry is usually a public law act regulated by domestic legislation. The international and national registration of space objects are accompanied by several other regimes of registration such as those of radio stations on board space objects, effectuated by the International Telecommunication Union.
Type 1: Resisting Self-Erasure
Authors: Marchesi Ilaria 
Published: May 2024

Abstract
This chapter analyses the skoptic rhetoric of Martial’s epigrams to define the first type of “negative” woman in ethical, sociological, and most distinctively semiotic terms. It presents three pairs of poems containing examples of womanly resistance, measured in linguistic, legal, and grammatical terms. The analysis moves from an observation of the naming mechanisms at work in various epigrams, through a consideration of Martial’s use of legal terminology to define some women’s status, to soundings into the semiotic ambivalence that basic verbs such as facere and dare acquire when they become the prerogative of women. The focus on Martial’s insistent interconnection of grammatical predication and sexual predication suggests that the Epigrams’ moralizations rest on a shared cultural social grammatology.
Type 2: Dominating the Semiotic Field
Authors: Marchesi Ilaria 
Published: May 2024

Abstract
This chapter focuses on Martial’s treatment of women who reverse the identity-defining mechanics of language, by projecting on men material wealth, social standing, and ultimately semiotic identity. Dominant women enjoy a vast representation in the Epigrams. The argument first reviews cases in which, by exercising economic or sexual power, women are shown to control the lexicon “defining” men who enter their sphere of influence; secondly, it concentrates on cases in which the material apparatus of the theatre becomes the means for dominating women to “stage” the men with whom they interact; finally, it addresses Martial’s deployment of charged non-grammatical and “unnatural” formulations to account for the social reality of matrimonial mismatches. When women become the fulcrum of male social self- and relational definition, their anxiety-triggering presence points to the tacitly accepted and seldom acknowledged instability of all material markers of social standing.
O03 Genetic impacts on the skin methylome
Authors: Shore Christopher , Muñoz Sergio Villicaña , Deloukas Panos , Gunn David , Bataille Veronique , Bell Jordana 
Published: May 2024

Abstract

Introduction and aims
DNA methylation at CpG dinucleotides is a dynamic epigenetic mechanism that has been linked to numerous skin phenotypes and diseases. Previous studies in blood show that a substantial proportion of the human DNA methylome exhibits evidence for genetic influence, and that 15–17% of narrow-sense methylation heritability is explained by genetic variants, or methylation quantitative trait loci (meQTLs). However, no genome-wide meQTL studies have previously been performed in skin. The primary purpose of this work was to identify the genetic basis of DNA methylation levels in whole skin.

Methods
Utilizing a twin-based heritability model, we estimated DNA methylation heritability using 414 bulk skin tissue samples from healthy older female twins from the TwinsUK cohort, profiled using the Illumina Infinium HumanMethylation450 BeadChip (Illumina, San Diego, CA, USA). We then integrated genomic data for 394 of these twins to perform genome-wide meQTL analyses. Finally, we integrated these meQTL Results with skin eQTL Results from an overlapping sample (N = 664).

Results
Over 8.2% of measured CpG sites showed evidence for strong heritability (h2 &gt; 0.4), with a mean additive heritability estimate of 11.07% across all tested sites. We identified 76 442 CpG sites (18.8% of measured CpG sites) associated with a meQTL in cis (&lt; 1 MB variant-CpG distance) and 1438 (0.35%) in trans. Both CpG sites under meQTL effects, and genetic variants underlying these meQTL effects in skin, are enriched in regions previously identified from genome-wide and epigenome-wide association studies for skin-related phenotypes, including psoriasis, melanoma and vitiligo. Additionally, some meQTLs influence gene expression via mediation of expression quantitative trait loci effects in skin, including in genes linked to melanoma and psoriasis.

Conclusions
Our study is the first genome-wide DNA methylation heritability and meQTL analysis of whole skin, giving insights into the regulatory landscape of epigenomic variation in skin.
P10 Janus kinase inhibitors to restore skin barrier function in a mouse model of Harlequin ichthyosis
Authors: Giusto Elena , Jones Eleri , Enjalbert Florence , Ahmed Abubkr , Caley Matthew , Rognoni Emanuel , O’Toole Edel 
Published: May 2024

Abstract

Introduction and aims
The autosomal recessive congenital ichthyoses (ARCIs) are a group of chronic conditions where there is unmet therapeutic need. Harlequin ichthyosis (HI) is the most severe form of ARCI with aberrant differentiation of the epidermis leading to a severe barrier defect. It is caused by mutations in ABCA12, a lipid transporter involved in transport of glucosylceramides from the lamellar body to the lipid lamellae. Several Janus kinase (JAK) inhibitors inhibiting the JAK-signal transducer and activator of transcription pathway are now licensed for atopic dermatitis. Previous work from our group in an HI in vitro model showed that tofacitinib, a pan-JAK inhibitor, had a restorative effect on the lipid barrier.

Methods
Further selective JAKis were tested in three dimensional skin equivalents using ABCA12 CRISPR-Cas9 knockout and wildtype keratinocytes to identify the most promising JAKi for use in an HI murine model (ABCA12tm1c: Het Cre+). JAKi-A (5 mg kg−1) and vehicle (10% dimethylsulfoxide in corn oil) were tested on male and female HI-inducible and wildtype mice (N = 4). All mice were initially treated with 4-OH-Tamoxifen to induce the HI phenotype and after 1 day JAKi-A was administered via oral gavage for 9 days. All mice were killed, and skin was collected and processed for haematoxylin and eosin, Nile Red, ABCA12, glucosylceramide and immune cell marker staining.

Results
JAKi-A had a positive effect on HI epidermal morphology, showing a significantly reduced epidermal thickness in treated HI mice compared with controls. JAKi-A also had a positive effect on the epidermal barrier, restoring neutral and polar lipids compared with vehicle-treated mice as observed using Nile Red and glucosylceramide staining. Further analysis on immune cell infiltrates is in progress.

Conclusions
These Results suggest that JAKi-A restores the skin barrier in vivo and may be a promising treatment for severe ichthyosis.
P36 Environmental triggers of psoriasis and relationship to disease severity: insights from the mySkin study
Authors: Kroah-Hartman Madeline , Dooley Niamh , Mineur Maaike , Tan William , Pizzato Jade , Jackson-Duffy Freya , Powell Kingsley , Sewell Georgia , Lancelot Camille , Moorhead Lucy , McAteer Helen , Coker Bola , Weinman John , Barker Jonathan , Chapman Sarah , Norton Sam , Smith Cathrine , Mahil Satveer 
Published: May 2024

Abstract

Introduction and aims
Psoriasis is a common debilitating inflammatory skin condition with an established genetic basis. Despite a wealth of genetic research on psoriasis susceptibility, epidemiological studies characterizing environmental triggers of disease onset are limited. Our aim is to identify self-reported triggers of psoriasis onset, and investigate the relationship between triggers and subsequent disease severity.

Methods
Self-reported data from people with a clinician-confirmed diagnosis of psoriasis were collected through the online mySkin survey. mySkin was launched UK-wide in June 2023 and all surveys completed by 6 December 2023 were analysed. Measures of disease severity at the time of survey completion included Patient Global Assessment and Dermatology Life Quality Index. The association between triggers of psoriasis onset and disease severity was analysed using one-way Anova tests.

Results
Of 529 participants, 93.4% were of White ethnicity, 64.8% were female and their average age was 51.1 years. Overall, 49.9% reported a family history of psoriasis and 55% (n = 289) of participants reported at least 1 trigger of psoriasis onset. Of those who reported a trigger, the most commonly reported trigger was stress (n = 167, 57.8%), followed by infection (n = 85, 29.4%) and low mood (n = 23, 7.9%). For participants who selected multiple triggers, there was considerable coselection of stress, low mood, climate (pollution, weather) and lifestyle (weight gain, alcohol, smoking) factors. A greater proportion of participants with a family history of psoriasis reported climate and hormonal (pregnancy, childbirth, menopause) triggers of psoriasis onset, compared with those without a family history (73% vs. 26% and 69% vs. 31%, respectively). There was no significant association between triggers of psoriasis onset and disease severity (P = 0.76).

Conclusions
These self-reported data highlight the importance of stress in psoriasis onset. The co-occurrence of different triggers, including in those with vs. without a family history of psoriasis, underscores the complex aetiology of psoriasis. Further characterization of gene–environment interactions is warranted.
Supporting Meaningful Implementation and Evaluation of Strengths-Based Approaches in Adult Social Care: A Theory of Change for The Three Conversations
Authors: Stevens Madeleine , Clark Michael , Carlisle Jessica , Brimblecombe Nicola , MacGill Miranda 
Published: May 2024

Abstract
There is much policy support internationally for ‘strengths-based approaches’ which work collaboratively with people seeking support. Such approaches aim to recognise the strengths in individuals, those around them, and their communities, to support people to be independent and focus services and support where most needed. However, there is little evidence of how such approaches work in practice or whether they are effective. The Three Conversations (3Cs) is one such approach. Development of practice and future evaluation requires that these approaches are better understood and articulated. To address this challenge, we worked collaboratively with three UK local authorities to understand how 3Cs is operating in practice, and how its evaluation could be considered. We used interviews and workshops with staff, carers and people receiving services, data collected by sites, and wider consultation to develop a theory of change setting out how 3Cs is thought to best operate and be implemented. We identified potential benefits and pitfalls when implementing 3Cs, and barriers to successfully incorporating 3Cs as ‘business as usual’. The theory of change, presented in this article, can be used to support implementation of strengths and relationship-based practice and its meaningful evaluation, and has relevance beyond The Three Conversations.
Clinical Presentation, Antimicrobial Resistance, and Treatment Outcomes of Aeromonas Human Infections: A 14-Year Retrospective Study and Comparative Genomics of 2 Isolates From Fatal Cases
Authors: Pineda-Reyes Roberto , Neil Blake H , Orndorff Joseph , Williams-Bouyer Natalie , Netherland Michael , Hasan Nur A , Tahashilder Md Ibrahim , Sha Jian , Chopra Ashok K , Reynoso David 
Published: May 2024

Abstract

Background
Aeromonas virulence may not be entirely dependent on the host’s immune status. Pathophysiologic determinants of disease progression and severity remain unclear.

Methods
One hundred five patients with Aeromonas infections and 112 isolates were identified, their clinical presentations and outcomes were analyzed, and their antimicrobial resistance (AMR) patterns were assessed. Two isolates (A and B) from fatal cases of Aeromonas dhakensis bacteremia were characterized using whole-genome sequencing. Virulence factor- and AMR-encoding genes from these isolates were compared with a well-characterized diarrheal isolate A. dhakensis SSU and environmental isolate Aeromonas hydrophila American Type Culture Collection_7966T.

Results
Skin and soft tissue infections, traumatic wound infections, sepsis, burns, and intraabdominal infections were common. Diabetes, malignancy, and cirrhosis were frequent comorbidities. Male sex, age ≥ 65 years, hospitalization, burns, and intensive care admission were associated with complicated disease. High rates of AMR to carbapenems and piperacillin-tazobactam were found. Treatment failure was observed in 25.7% of cases. Septic shock and hospital-acquired infections were predictors of treatment failure. All 4 isolates harbored assorted broad-spectrum AMR genes including blaOXA, ampC, cphA, and efflux pumps. Only clinical isolates possessed both polar and lateral flagellar genes, genes for various surface adhesion proteins, type 3 and 6 secretion systems and their effectors, and toxin genes, including exotoxin A. Both isolates A and B were resistant to colistin and harbored the mobile colistin resistance-3 (mcr-3) gene.

Conclusions
Empirical therapy tailored to local antibiograms may facilitate favorable outcomes, while advanced diagnostic methods may aid in identifying correct Aeromonas spp. of significant clinical importance.