bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic variants associated with myocardial infarction in the PSMA6 gene and Chr9p21 are also associated with ischaemic stroke
Authors: Heckman M. G. , Soto‐Ortolaza A. I. , Diehl N. N. , Rayaprolu S. , Brott T. G. , Wszolek Z. K. , Meschia J. F. , Ross O. A. 
Published: August 2012

BackgroundIschaemic stroke shares common traditional risk factors with coronary artery disease (CAD) and myocardial infarction (MI). This study evaluated whether genetic risk factors for CAD and MI also affect susceptibility to ischaemic stroke in Caucasians and African Americans.MethodsIncluded in the study were a Caucasian series (713 ischaemic stroke patients, 708 controls) and a small African American series (166 ischaemic stroke patients, 117 controls). Twenty single‐nucleotide polymorphisms (SNPs) previously shown to be associated with CAD or MI were genotyped and assessed for association with ischaemic stroke and ischaemic stroke subtypes using odds ratios (ORs) from multivariable logistic regression models.ResultsIn Caucasians, four SNPs on chromosome 9p21 were significantly associated with risk of cardioembolic stroke, the strongest of which was rs1333040 (OR 1.55, P = 0.0007); similar but weaker trends were observed for small vessel stroke, with no associations observed regarding large vessel stroke. Chromosome 9p21 SNPs were also associated with risk of ischaemic stroke in African Americans (rs1333040, OR 0.65, P = 0.023; rs1333042, OR 0.55, P = 0.070; rs2383207, OR 0.55, P = 0.070). The PSMA6 SNP rs1048990 on chromosome 14q13 was associated with overall ischaemic stroke in both Caucasians (OR 0.80, P = 0.036) and African Americans (OR 0.31, P = 0.020).ConclusionsOur results provide evidence that chromosome 9p21 variants are associated with cardioembolic ischaemic stroke in Caucasians and with overall ischaemic stroke in African Americans. The PSMA6 variant rs1048990 also appears to affect susceptibility to ischaemic stroke in both populations. These findings require validation, particularly the preliminary findings regarding African Americans given the small size of that series.
Hereditary angioedema: first report of the Brazilian registry and challenges
Authors: Grumach A.S. , Valle S.O.R. , Toledo E. , de Moraes Vasconcelos D. , Villela M.M.S. , Mansour E. , Pinto J.A. , Campos R.A. , França A.T. ,   On behalf of group interested on HAE (GINHA)
Published: August 2012

AbstractBackground  Hereditary Angio‐oedema (HAE) is a serious medical condition caused by a rare autosomal dominant genetic disorder, in which C1 inhibitor (C1‐INH) function is reduced. There is no organized information on the HAE patient population in Brazil.Objective  The Brazilian Registry was established to disseminate diagnostic access, and to better understand the main features of the disease in our country and its clinical impact.Methods  A questionnaire was prepared and sent to specialists. The completed questionnaires were forwarded to the coordinating site and then entered into the Registry. Samples from patients with an unconfirmed diagnosis were tested for C1 inhibitor and C4 levels.Results  From 2006 to 2010, 210 patients (133 females; mean age, 30 ±17 years) were included. The median age of onset of symptoms and age at diagnosis were 6.5 and 21 years, respectively; 80.9% of the patients had subcutaneous oedema, 54% gastrointestinal and 35.7% respiratory symptoms (21% had laryngeal oedema). Laparotomy due to the disease was performed in 6.2% of the patients. The majority of patients had Type I HAE of moderate severity. Twenty‐seven per cent did not receive treatment; 53% were treated with danazol alone.Conclusion  A paucity of patients with Type II HAE and a high frequency of laparotomy were observed, highlighting the need for better diagnosis in Brazil. HAE related educational activities, improved diagnosis and access to available therapy are needed in Brazil.
c‐myc in Kaposi’s sarcoma: analyses by fluorescent in situ hybridization and immunohistochemistry
Authors: Feller K. , Yang S. , Tung N. , Lee J. , Mahalingam M. 
Published: August 2012

AbstractBackground  The c‐myc proto‐oncogene plays a central role in the regulation of cellular transcription, differentiation, and apoptosis, and has been shown to be deregulated in many types of human cancer. Recent findings have demonstrated its amplification in select vascular neoplasms, such as secondary angiosarcomas, suggesting a role in angiogenesis as well. In vitro studies have shown that the c‐Myc protein is an important regulatory molecule of spindle cell proliferation and migration in Kaposi’s sarcoma (KS).Objectives  In light of these findings, our primary aim was to ascertain whether c‐myc, by promoting proliferation and angiogenesis, is an essential co‐factor in the aetiopathogenesis of KS. We also attempted to determine a correlation between immunohistochemical expression of the c‐Myc protein and c‐myc gene copy amplification using fluorescent in situ hybridization (FISH).Methods  Samples analyzed included archival tissue of KS (n = 24). PCR for detection of Kaposi’s sarcoma‐associated herpesvirus DNA was performed on all samples of KS. For FISH analyses, a dual‐labelled technique was employed and probes for the c‐myc gene and chromosome 8 were used. The monoclonal anti‐c‐myc antibody, 9E10, was used for immunohistochemical analyses.Results  While FISH analyses revealed no amplification of c‐myc in any of the cases of KS, immunohistochemical analyses revealed positive staining for c‐Myc in 13/24 cases (54%).Conclusions  Amplification of the c‐myc gene was not witnessed in this preliminary study of 24 cases and thus cannot be correlated with the expression of the c‐Myc protein.
Preliminary exploration of the clinical features of Chinese patients with skin malignancies and premalignancies: a retrospective study of 1420 cases from Peking University First Hospital
Authors: Huang Y.S. , Chen X.X. , Yang S.X. , Wu L.S. , Zhao J.Y. , Li X.Y. , Tu P. , Li H. 
Published: August 2012

AbstractBackground  The epidemiological and clinical characterization data of skin malignancies and premalignancies in Chinese population is scarce and inadequate.Objective  To systematically investigate the clinical features and the trend of skin malignancies and premalignancies in 1420 Chinese cases.Methods  A total of 1398 patients (presenting 1420 skin tumours) were included. Clinical and demographic information for every individual was collected, including age, age of onset, sex, lesion location, disease duration and tumour histology, which was analyzed for each type of skin tumours.Results  The number of skin malignancies and premalignancies increased over time, with Basal cell carcinoma (BCC) as the most common type (30.5%). The majority of the patients were above 60 years of age both at onset and at diagnosis (52.8% and 62.9%, respectively), yet around one‐third of patients were between 35–59 years (35.3% and 31.2%, respectively). Skin malignancies and premalignancies were mainly located in the head and neck (58.6%), followed by the trunk (18.3%) and the extremities (15.0%). Of all BCCs, nodular BCC was the most common histologic subtype (62.8%), while 15.8% were classified as aggressive subtypes. Malignant melanoma (MM) comprised the lowest proportion of 3.7%, with 75% located on extremities. The diagnostic accordance rates varied from 49.5% to 90.4%, with BCC being 67.9%.Conclusions  The clinical features of skin malignancies and premalignancies in this study showed some similarities with those observed in Caucasian and other Asian populations, with several distinguished features in Chinese patients also being recognized. Closer attention to suspicious lesions in young and middle‐aged people is needed.
Teaching emotion recognition skills to young children with autism: a randomised controlled trial of an emotion training programme
Authors: Williams Beth T. , Gray Kylie M. , Tonge Bruce J. 
Published: August 2012

Background:  Children with autism have difficulties in emotion recognition and a number of interventions have been designed to target these problems. However, few emotion training interventions have been trialled with young children with autism and co‐morbid ID. This study aimed to evaluate the efficacy of an emotion training programme for a group of young children with autism with a range of intellectual ability.Methods:  Participants were 55 children with autistic disorder, aged 4–7 years (FSIQ 42–107). Children were randomly assigned to an intervention (n = 28) or control group (n = 27). Participants in the intervention group watched a DVD designed to teach emotion recognition skills to children with autism (the Transporters), whereas the control group watched a DVD of Thomas the Tank Engine. Participants were assessed on their ability to complete basic emotion recognition tasks, mindreading and theory of mind (TOM) tasks before and after the 4‐week intervention period, and at 3‐month follow‐up.Results:  Analyses controlled for the effect of chronological age, verbal intelligence, gender and DVD viewing time on outcomes. Children in the intervention group showed improved performance in the recognition of anger compared with the control group, with few improvements maintained at 3‐month follow‐up. There was no generalisation of skills to TOM or social skills.Conclusions:  The Transporters programme showed limited efficacy in teaching basic emotion recognition skills to young children with autism with a lower range of cognitive ability. Improvements were limited to the recognition of expressions of anger, with poor maintenance of these skills at follow‐up. These findings provide limited support for the efficacy of the Transporters programme for young children with autism of a lower cognitive range.
LateDevonian marine anoxia challenged by benthic cyanobacterial mats
Authors: Kazmierczak J. , Kremer B. , Racki G. 
Published: August 2012

AbstractMass occurrence of benthic cyanobacterial mats in a sequence ofLateDevonian black shales and bituminous limestones of theHolyCrossMts. (centralPoland), enclosing the famousKellwasser andHangenberg extinction horizons, is reported. The microbiota forming the mats is compared with some modern benthic chroococcalean cyanobacteria. Similarly to their extant counterparts, theDevonian cyanobacteria must had been phototrophic and oxygenic aerobes which could, however, tolerate slightly sulfidic conditions characterizing the near‐bottom waters of theLateDevonian epicontinental sea. The cyanobacterial mats successfully colonized the oxygen‐deficient and H2S‐enriched seabed otherwise unfavorable for most other benthic biota. The redox state of this sluggishLateDevonian sea, ascribed previously mostly to anoxic or euxinic conditions, is reassessed as probably pulsating between anoxic, dysoxic, and weakly oxic conditions. The redox state was dependent on the rate of oxygen production by the cyanobacterial mats, the intensity ofH2Semissions from the decaying mat biomass, and the rate of planktonic production.
European consensus document on mast cell tumours in dogs and cats
Authors: Blackwood L. , Murphy S. , Buracco P. , De Vos J. P. , De Fornel‐Thibaud P. , Hirschberger J. , Kessler M. , Pastor J. , Ponce F. , Savary-Bataille K. , Argyle D. J. 
Published: August 2012

Statement from the AuthorsIn preparing this document the Authors aimed to pool current information on canine and feline mast cell disease. The information was gathered from international studies and a emphasis was placed on material and opinion with a strong evidence base. We intend it to form the basis of our understanding in this disease at the current time and we anticipate that it will be particularly useful for the general practitioner. It should be emphasized that the authors are presenting this work from a European perspective.
Two new species ofCicadatra(Hemiptera:Cicadoidea) fromGreece
Authors: Simões Paula Cristina , Sanborn Allen , Quartau José Alberto 
Published: August 2012

AbstractThe present study is the description of two new species ofCicadatraKolenati, 1857 found in some Greek islands during the summers of 1998 and 2001.Cicadatra icarisp. n.is described fromIkaria andSamos andCicadatra karpathosensissp. n.fromKarpathos. Description of the external morphology is provided. The male genitalia were dissected for close examination and illustration. Acoustic signals produced by males were recorded and analyzed and a description of the calling songs is provided. Discrimination from the closely allied species is also provided.
Comparison of the Location of Slow Conduction Velocity in Cavotricuspid‐Dependent Atrial Flutter in Patients With and Without Prior Atriotomy: Different Arrhythmogenic Basis and Clinical Implications for Placement of Atriotomy
Authors: YANG BING , JU WEIZHU , CHEN HONGWU , ZHANG FENGXIANG , CHEN KAI , GU KAI , CAO KEJIANG , CHEN MINGLONG 
Published: August 2012

Slow Zone in CTI‐Dependent Flutter After Atriotomy. Introduction: Earlier studies have shown that the slow conduction zone in patients with cavotriscuspid (CTI)‐dependent atrial flutter without prior surgery (NS‐AFL) is the CTI. However, the location of this slow zone in patients with CTI‐dependent flutter and a prior atriotomy has not been formally studied. Identification of the slow zone in patients with prior atriotomy and CTI‐dependent atrial flutter (PA‐AFL) and comparison with NS‐AFL may have important clinical implications.
Methods and Results:
Seventeen consecutive patients with PA‐AFL and 17 consecutive patients with NS‐AFL were included. Conduction velocity (CV) was measured using 3‐dimensional mapping in 3 areas around the TVA. These regions were defined as the CTI area from lateral inferior vena cava orifice to coronary sinus ostium (region I), mid‐ to upper‐septum (S), and free wall (F). In region F, the CV was much slower in PA‐AFL than in NS‐AFL patients (0.43 ± 0.13 vs 0.76 ± 0.26 m/s, P < 0.01). However, region I was slower in NS‐AFL than PA‐AFL (0.57 ± 0.18 m/s vs 0.84 ± 0.24 m/s, P < 0.01). In all PA‐AFL patients, the slow zone was in region F. But in most (11/17) NS‐AFL patients the slow zone was in region I. There was no significant difference in CV in region S between the 2 groups.
Conclusions:
Unlike NS‐AFL, CTI in PA‐AFL displays relatively normal conduction but the slow zone is on the free wall. This arrhythmogenecity of atriotomy may perhaps be avoided if the incisional line were altered to extend to the TV. (J Cardiovasc Electrophysiol, Vol. 23, pp. 988‐995, September 2012)
Building Green: Local Political Leadership Addressing Climate Change
Authors: Lee Taedong , Koski Chris 
Published: August 2012

AbstractMunicipal agreements have been instrumental in communicating commitment to addressing climate change at the local level. However, what is the practical implication of this potentially symbolic decision? This study examines the power of mayoral participation in climate change agreements in driving the proliferation of sustainable or “green” building in a city as a mechanism to reach its climate change goals. In addition, mayors can localize what is otherwise a public good by framing green buildings as having other tangible impacts on a community. We analyze the impact of political leadership on green building projects in 591 cities in 50 U.S. states, controlling for a variety of city‐ and state‐level variables. Hierarchical models indicate that mayoral leadership in climate change policy fosters green building, while state‐level predictors are not as important as city policy in creating green buildings. Our research concludes that local governments can be a very effective venue in addressing broad climate change goals.
An Assessment of the Impact that Participation in Local Climate Networks Has on Cities’ Implementation of Climate, Energy, and Transportation Policies
Authors: Krause Rachel M. 
Published: August 2012

AbstractMuch of the attention surrounding local climate protection in the United States is associated with two networks: ICLEI Local Governments for Sustainability's Cities for Climate Protection and the U.S. Conference of Mayors’ Climate Protection Agreement (MCPA). However, the impact of these networks on member‐city actions has not been clearly established. This paper examines whether, and to what extent, participation in climate networks leads to the implementation of greenhouse gas (GHG)‐reducing policies, above and beyond what would have been done in their absence. To account for the possibility that cities which join climate networks are systematically different from those that do not and control for self‐selection induced bias, three statistical techniques—propensity score matching, Heckman full information maximum likelihood, and instrumental variables—are employed to estimate the “treatment effect” of participation. Results suggest that impact is network specific: ICLEI membership causes small to moderate increases in cities’ GHG‐relevant activity, whereas the MCPA has no such effect. The characteristics of each network are evaluated in light of these findings.
Nonpunctuated and Sweeping Policy Change:Bhutan Tobacco Policy Making from 1991 to 2009
Authors: Givel Michael 
Published: August 2012

AbstractThis paper examines policy outputs associated with the 2004Bhutan antitobacco law, including 2009 amendments, to determine if the law is congruent with punctuated equilibrium or social policy realism theories of policy change. There was no direct and sudden tobacco policy output change inBhutan due to a shock to the policy system contrary to what punctuated equilibrium theory would predict. Rather, policy change was sweeping but nonpunctuated. This paper reconfirms prior findings of social policy realism theory that various and complex policy output patterns occur due to a mixture of contingent and complex factors. Under social policy realism, a complex interplay of factors drive policy with the state, corporate actors, and interest groups, and the market often playing a primary role. These complex policy outputs have a direct impact on society and the natural environment reflected in government policy output actions or inactions.
Comparison of Nurse Burnout Across Army Hospital Practice Environments
Authors: Lang Gary Morris , Patrician Patricia , Steele Nancy 
Published: August 2012

AbstractPurpose: The primary purpose of this study was to examine the nursing practice environment and burnout of nursing personnel assigned to a deployed combat support hospital (CSH). A secondary aim was to compare differences in the level of burnout between the deployed Army nursing personnel and Army nursing personnel assigned to an Army hospital in the United States that served as the U.S. military's primary referral center for American combat casualties evacuated from Iraq.Design: A nonexperimental cross‐sectional design was used for this study.Methods: The Maslach Burnout Inventory and the Practice Environment Scale were administered to 105 personnel who deployed with a CSH to Iraq. Data from this study were linked to data obtained from 152 nursing personnel who participated in an earlier burnout study at a large Army hospital in the United States. The linked datasets yielded a final sample of 257 Army nursing personnel. Analysis of variance and linear regression analysis were used to analyze these data.Findings: Emotional exhaustion was common across groups. For the deployed nursing personnel, emotional exhaustion was related to a perceived lack of support from management, foundations for quality of care, collegial relationships, and extended work schedules. The U.S.‐based Army hospital group scored significantly higher emotional exhaustion, but it was related to the additional responsibilities associated with being an Army nurse, working extended schedules, and working with combat casualties for extended periods of time. The U.S.‐based group perceived more personal accomplishment from the work they do.Conclusions: Burnout was common across Army hospital settings. Emotional exhaustion was most problematic in the U.S.‐based Army hospital; however, there was less cynicism toward patients and a greater perception of personal accomplishment associated with work.Clinical Relevance: This study supports the importance of a professional practice environment for Army nursing personnel both during deployment and in U.S.‐based Army hospitals. Journal of Nursing Scholarship, 2011; XX:X, XXX–XXX. ©2011 Sigma Theta Tau International.
Nurses’ Sociodemographic Background and Assessments of Individualized Care
Authors: Idvall Ewa , Berg Agneta , Katajisto Jouko , Acaroglu Rengin , Luz Maria Deolinda Antunes da , Efstathiou Georgios , Kalafati Maria , Kanan Nevin , Leino‐Kilpi Helena , Lemonidou Chryssoula , Papastavrou Evridiki , Sendir Merdiye , Suhonen Riitta 
Published: August 2012

AbstractAim: The aim of this study was to explore the association between nurses’ characteristics (educational level, country, work title, gender, type of work, age, and length of working experience) and their assessments of individualized care.Design: A cross‐sectional comparative survey using questionnaires was employed to sample nurses from seven countries.Methods: Data were collected from orthopedic and trauma nurses from Cyprus, Finland, Greece, Portugal, Sweden, Turkey, and the United States (N= 1,163, response rate 70%) using the Individualized Care Scale‐Nurse (ICS‐Nurse) and a sociodemographic questionnaire in 2008. Data were analyzed using descriptive statistics and general linear models.Results: When compared with practical nurses, registered nurses, length of working experience, and the country of the nurses were associated with assessments of the support of patient individuality in specific nursing activities (ICS‐A‐Nurse) and country assessments of individuality in the care provided (ICS‐B‐Nurse). The background and experience within nursing teams together with the country affect the delivery of individualized care.Conclusions: Overall, our findings suggest that nurses’ personal attributes have important effects on their assessments of individualized nursing care that will be useful when making context‐dependent recruitment decisions.Clinical Relevance: The characteristics of nurses contribute to the care delivered in healthcare organizations. Recognition of these nurse‐related factors may help nurse leaders in the development and management of clinical practice.Journal of Nursing Scholarship, 2012; 44:3 ©2012 Sigma Theta Tau International.