bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: First Domino Radical Cyclization/Smiles Rearrangement Combination.
Authors: Pudlo Marc , Allart‐Simon Ingrid , Tinant Bernard , Gerard Stephane , Sapi Janos 
Published: June 2012

AbstractA novel domino radical cyclization/Smiles rearrangement reaction of amides (VI) in decane leads readily to indolinones (VII) as main or sole products.
ChemInform Abstract: Regioselective Zincation of Indazoles Using TMP2Zn and Negishi Cross‐Coupling with Aryl and Heteroaryl Iodides.
Authors: Unsinn Andreas , Knochel Paul 
Published: June 2012

AbstractThe metallation of various Sem‐protected functionalized indazoles (I), (IV) and (VII) with tetramethylpiperidyl zinc provides selectively 3‐zincated indazoles which undergo Pd‐catalyzed Negishi cross‐couplings with electrophiles (II), (V) and (VIII) in good yields.
ChemInform Abstract: Highly Regioselective One‐Pot, Three‐Component Synthesis of 1‐Aryl‐3,4‐Substituted/Annulated‐5‐(Cycloamino)/(Alkylamino)pyrazoles from β‐Oxodithioesters.
Authors: Nandi Ganesh C. , Singh Maya S. , Ila Hiriyakkanavar , Junjappa Hiriyakkanavar 
Published: June 2012

AbstractPyrazole derivatives are synthesized by cyclocondensation of β‐oxodithioester, cyclic secondary and primary aliphatic amines and aryl hydrazines (III) in the presence of acetic acid.
ChemInform Abstract: Novel Synthetic Methods for N‐Cyano‐1H‐imidazole‐4‐carboxamides and Their Fungicidal Activity.
Authors: Yang Wen‐Chao , Li Jing , Li Jun , Chen Qiong , Yang Guang‐Fu 
Published: June 2012

AbstractCompound (IIIe) exhibits excellent antifungal activity against Rhizoctonia solani.
ChemInform Abstract: Assembly of 3‐Substituted Isocoumarins via a CuI‐Catalyzed Domino Coupling/Addition/Deacylation Process.
Authors: Cai Shangjun , Wang Fei , Xi Chanjuan 
Published: June 2012

AbstractCuI‐catalyzed treatment of o‐halobenzoic acids with the diketones (IIa)—(IId) and (IV) allows a new and efficient access to a wide range of biologically interesting title compounds.
ChemInform Abstract: Rapid Access to Chroman‐3‐ones Through Gold‐Catalyzed Oxidation of Propargyl Aryl Ethers.
Authors: Wang Yanzhao , Ji Kegong , Lan Sylvester , Zhang Liming 
Published: June 2012

AbstractAn efficient one‐pot method for the synthesis of the title compounds uses easily accessible pyridine N‐oxides (I), derived from Hantzsch esters.
ChemInform Abstract: Hg(OTf)2‐Catalyzed Vinylogous Semi‐Pinacol Rearrangement Leading to 1,4‐Dihydroquinolines.
Authors: Namba Kosuke , Kanaki Michika , Suto Hiroki , Nishizawa Mugio , Tanino Keiji 
Published: June 2012

AbstractThe reaction, applied to various tosylanilinoallyl acetals to construct 1,4‐dihydroquinoline products bearing a quaternary carbon center, is very sensitive to the amount of mercury catalyst used.
ChemInform Abstract: Synthesis, Structure, and Luminescent Properties of 2‐[2‐(9‐Anthryl)vinyl]quinolines.
Authors: Serdyuk O. V. , Evseenko I. V. , Dushenko G. A. , Revinskii Yu. V. , Mikhailov I. E. 
Published: June 2012

AbstractIt is shown that compound (Ib) exhibits a considerably higher luminescence than compound (Ia).
ChemInform Abstract: An Efficient Synthesis of Highly Functionalized Novel Chromeno[4,3‐b]pyrroles and Indolizino[6,7‐b]indoles as Potent Antimicrobial and Antioxidant Agents.
Authors: Arumugam Natarajan , Raghunathan Raghavachary , Almansour Abdulrahman I. , Karama Usama 
Published: June 2012

AbstractAmong the novel chromenopyrroles (III) and indolizinoindoles (V) and (VI), derivatives (Vb), (Vd), (VIb), and (VId) display potent activity against selected bacterial pathogens, while derivatives (Va) and (Vc) possess antifungal activity.
ChemInform Abstract: Electrocatalytic and Chemical Assembling of N,N′‐Dialkylbarbituric Acids and Aldehydes: Efficient Cascade Approach to the Spiro‐[furo [2,3‐d]pyrimidine‐6,5′‐pyrimidine]‐2,2′,4,4′,6′‐(1′H,3H,3′H)‐pentone Framework.
Authors: Vereshchagin Anatolii N. , Elinson Michail N. , Dorofeeva Evgeniya O. , Zaimovskaya Tatiana A. , Stepanov Nikita O. , Gorbunov Sergey V. , Belyakov Pavel A. , Nikishin Gennady I. 
Published: June 2012

AbstractThe electrocatalytical method is performed with catalytic amounts of NaBr in an undivided cell.
ChemInform Abstract: Intramolecular Pd(II)‐Catalyzed Aerobic Oxidative Amination of Alkenes: Synthesis of Six‐Membered N‐Heterocycles.
Authors: Lu Zhan , Stahl Shannon S. 
Published: June 2012

AbstractVarious heterocyclic sulfonamides like morpholines, piperidines, piperazines and piperazinone are prepared using Wacker‐type cyclization under conditions A) without any base.
ChemInform Abstract: Synthesis of Paullone and Kenpaullone Derivatives by Photocyclization of 2‐(2‐Chloro‐1H‐indol‐3‐yl)‐N‐arylacetamides.
Authors: Li Zhanshan , Lu Nianhong , Wang Lihong , Zhang Wei 
Published: June 2012

AbstractPhotoinduced intramolecular coupling reaction of indolyl arylacetamides (I) results in formation of indolobenzazepinones (III).
ChemInform Abstract: T3P (Propylphosphonic Anhydride) Mediated Conversion of Nα‐Protected Amino/Peptide Acids into Thioacids.
Authors: Madhu Chilakapati , Basavaprabhu Basavaprabhu , Vishwanatha T. M. , Sureshbabu Vommina V. 
Published: June 2012

AbstractA simple protocol is described which can be applied to dipeptides as well.
ChemInform Abstract: Stylissamide X (I), a New Proline‐Rich Cyclic Octapeptide as an Inhibitor of Cell Migration, from an Indonesian Marine Sponge of Stylissa sp.
Authors: Arai Masayoshi , Yamano Yoshi , Fujita Mayumi , Setiawan Andi , Kobayashi Motomasa 
Published: June 2012

Abstractisolation, structure elucidation and screening of inhibitory activity against migration of HeLa cells
ChemInform Abstract: Reactivity of Sugar α‐Aminonitrile Derivatives under Titanium‐Mediated Cyclopropanation Conditions.
Authors: Declerck Delphine , Josse Solen , Nguyen Van Nhien Albert , Szymoniak Jan , Bertus Philippe , Postel Denis 
Published: June 2012

AbstractAmide, lactam, and imide furanose derivatives are studied.
ChemInform Abstract: Regioselectivity Among Six Secondary Hydroxyl Groups: Selective Acylation of the Least Reactive Hydroxyl Groups of Inositol
Authors: Vibhute Amol M. , Vidyasagar Adiyala , Sarala Saritha , Sureshan Kana M. 
Published: June 2012

Abstractusing cheap and readily accessible sulfuric acid immobilized on silica as catalyst
ChemInform Abstract: Enantioselective Total Synthesis of (+)‐Galbulin via Organocatalytic Domino Michael—Michael—Aldol Condensation.
Authors: Hong Bor‐Cherng , Hsu Che‐Sheng , Lee Gene‐Hsiang 
Published: June 2012

AbstractNatural lignan (+)‐galbulin (IV) is prepared via organocatalytic double Michael reaction of aldehyde (I) with ketoaldehyde (II) and a subsequent TosOH‐promoted intramolecular aldol condensation as key steps.
Synthesis and Application of the First Radioligand Targeting the Allosteric Binding Pocket of Chemokine Receptor CXCR3
Authors: Bernat Viachaslau , Heinrich Markus R. , Baumeister Paul , Buschauer Armin , Tschammer Nuska 
Published: June 2012

AbstractStrategies for the identification of allosteric modulators of chemokine receptors largely rely on various cell‐based functional assays. Radioligand binding assays are typically not available for allosteric binding sites. We synthesized, purified, and applied the first tritium‐labeled allosteric modulator of the human chemokine receptor CXCR3 (RAMX3, [3H]N‐{1‐[3‐(4‐ethoxyphenyl)‐4‐oxo‐3,4‐dihydropyrido[2,3‐d]pyrimidin‐2‐yl]ethyl}‐2‐[4‐fluoro‐3‐(trifluoromethyl)phenyl]‐N‐[(1‐methylpiperidin‐4‐yl)methyl]acetamide). RAMX3 is chemically derived from 8‐azaquinazolinone‐type allosteric modulators and binds to the CXCR3 receptor with a Kd value of 1.08 nM (specific activity: 80.4 Ci mmol−1). Radioligand displacement assays showed potent negative cooperativity between RAMX3 and chemokine CXCL11, providing a basis for the use of RAMX3 to investigate other potential allosteric modulators. Additionally, the synthesis and characterization of a number of other full and truncated 8‐azaquinazoline analogues were used to validate the binding properties of RAMX3. We demonstrate that RAMX3 can be efficiently used to facilitate the discovery and characterization of small molecules as allosteric modulators of the CXCR3 receptor.
Library Screening by Means of Mass Spectrometry (MS) Binding Assays—Exemplarily Demonstrated for a Pseudostatic Library Addressing γ‐Aminobutyric Acid (GABA) Transporter 1 (GAT1)
Authors: Sindelar Miriam , Wanner Klaus T. 
Published: June 2012

AbstractIn the present study, the application of mass spectrometry (MS) binding assays as a tool for library screening is reported. For library generation, dynamic combinatorial chemistry (DCC) was used. These libraries can be screened by means of MS binding assays when appropriate measures are taken to render the libraries pseudostatic. That way, the efficiency of MS binding assays to determine ligand binding in compound screening with the ease of library generation by DCC is combined. The feasibility of this approach is shown for γ‐aminobutyric acid (GABA) transporter 1 (GAT1) as a target, representing the most important subtype of the GABA transporters. For the screening, hydrazone libraries were employed that were generated in the presence of the target by reacting various sets of aldehydes with a hydrazine derivative that is delineated from piperidine‐3‐carboxylic acid (nipecotic acid), a common fragment of known GAT1 inhibitors. To ensure that the library generated is pseudostatic, a large excess of the nipecotic acid derivative is employed. As the library is generated in a buffer system suitable for binding and the target is already present, the mixtures can be directly analyzed by MS binding assays—the process of library generation and screening thus becoming simple to perform. The binding affinities of the hits identified by deconvolution were confirmed in conventional competitive MS binding assays performed with single compounds obtained by separate synthesis. In this way, two nipecotic acid derivatives exhibiting a biaryl moiety, 1‐{2‐[2′‐(1,1’‐biphenyl‐2‐ylmethylidene)hydrazine]ethyl}piperidine‐3‐carboxylic acid and 1‐(2‐{2′‐[1‐(2‐thiophenylphenyl)methylidene]hydrazine}ethyl)piperidine‐3‐carboxylic acid, were found to be potent GAT1 ligands exhibiting pKi values of 6.186±0.028 and 6.229±0.039, respectively. This method enables screening of libraries, whether generated by conventional chemistry or DCC, and is applicable to all kinds of targets including membrane‐bound targets such as G protein coupled receptors (GPCRs), ion channels and transporters. As such, this strategy displays high potential in the drug discovery process.
Information Processing with Molecules—Quo Vadis?
Authors: Pischel Uwe , Andréasson Joakim , Gust Devens , Pais Vânia F. 
Published: June 2012

AbstractInformation processing at the molecular level is coming of age. Since the first molecular AND gate was proposed about 20 years ago, the molecular interpretation of binary logic has become vastly more sophisticated and complex. However, the field is also at a crossroads. While cleverly designed molecular building blocks are abundant, difficult questions remain. How can molecular components be flexibly assembled into larger circuits, and how can these components communicate with one another. The concept of all‐photonic switching with photochromic supermolecules has shown some interesting potential and is discussed in this review. Although the field of molecular logic was originally discussed mainly in terms of a technology that might compete with solid‐state computers, potential applications have expanded to include clever molecular systems and materials for drug delivery, sensing, probing, encoding, and diagnostics. These upcoming trends, which are herein illustrated by selected examples, deserve general attention.
Rapid Estimation of Thermodynamic Parameters and Vapor Pressures of Volatile Materials at Nanoscale
Authors: Hikal Walid M. , Paden Jeffrey T. , Weeks Brandon L. 
Published: June 2012

AbstractNon‐isothermal measurements of thermodynamic parameters and vapor pressures of low‐volatile materials are favored when time is a crucial factor to be considered, such as in the case of detection of hazardous materials. In this article, we demonstrate that optical absorbance spectroscopy can be used non‐isothermally to estimate the thermodynamic properties and vapor pressures of volatile materials with good accuracy. This is the first method to determine such parameters in nanoscale in just minutes. Trinitrotoluene (TNT) is chosen because of its low melting temperature, which makes it impossible to determine its thermodynamic parameter by other rising‐temperature techniques, such as thermogravimetric analysis (TGA). The well‐characterized vapor pressure of benzoic acid is used to calibrate the spectrometer in order to determine the vapor pressure of low‐volatile TNT. The estimated thermodynamic properties of both benzoic acid and TNT are in excellent agreement with the literature. The estimated vapor pressure of TNT is one order of magnitude larger than that determined isothermally using the same method. However, the values are still within the range reported in the literature. The data indicate the high potential for use of rising‐temperature absorbance spectroscopy in determining vapor pressures of materials at nanometer scale in minutes instead of hours or days.
Successional stage of biological soil crusts: an accurate indicator of ecohydrological condition
Authors: Belnap Jayne , Wilcox Bradford P. , Van Scoyoc Matthew W. , Phillips Susan L. 
Published: June 2012

ABSTRACTBiological soil crusts are a key component of many dryland ecosystems. Following disturbance, biological soil crusts will recover in stages. Recently, a simple classification of these stages has been developed, largely on the basis of external features of the crusts, which reflects their level of development (LOD). The classification system has six LOD classes, from low (1) to high (6). To determine whether the LOD of a crust is related to its ecohydrological function, we used rainfall simulation to evaluate differences in infiltration, runoff, and erosion among crusts in the various LODs, across a range of soil depths and with different wetting pre‐treatments. We found large differences between the lowest and highest LODs, with runoff and erosion being greatest from the lowest LOD. Under dry antecedent conditions, about 50% of the water applied ran off the lowest LOD plots, whereas less than 10% ran off the plots of the two highest LODs. Similarly, sediment loss was 400 g m−2 from the lowest LOD and almost zero from the higher LODs. We scaled up the results from these simulations using the Rangeland Hydrology and Erosion Model. Modelling results indicate that erosion increases dramatically as slope length and gradient increase, especially beyond the threshold values of 10 m for slope length and 10% for slope gradient. Our findings confirm that the LOD classification is a quick, easy, nondestructive, and accurate index of hydrological condition and should be incorporated in field and modelling assessments of ecosystem health. Published in 2012. This article is a U.S. Government work and is in the public domain in the USA.
Hydrolytic Hydrogen Generation Using Milled Aluminum in Water Activated by Li, In, and Zn Additives
Authors: Fan M. Q. , Liu S. , Wang C. , Chen D. , Shu K. Y. 
Published: June 2012

AbstractA method for obtaining hydrogen through the hydrolytic reaction of highly activated aluminum (Al) alloy is investigated. The optimized Al–3 wt.% Li–4 wt.% In–7 wt.% Zn alloy significantly improves the maximum hydrogen generation rate and amount (137 mL g–1 min–1 and 1,243 mL g–1, respectively). An efficiency of 100% was reached within 1 h at 298 K. The synergistic catalytic effects of Li, In, and Zn, which stimulated Al hydrolysis through the formation of micro galvanic cells of In–Li and Al–In–Zn alloys in water, were observed. The reactions were analyzed using X‐ray diffraction, scanning electron microscopy, transmission electron microscopy, and hydrolytic experiments. The In–Li alloy functions as an initial active center and produces LiOH in water, which further stimulates and changes the hydrolytic process of the Al–In–Zn alloy. The effects of alloy composition, milling time, and hydrolytic temperature were considered and discussed. The results indicate that the hydrolytic reaction of Al–Li–In–Zn alloy in water might be feasible for the production of inexpensive, pure, and safe hydrogen for micro fuel cells.
Blockade of TRPA1 with HC‐030031 attenuates visceral nociception by a mechanism independent of inflammatory resident cells, nitric oxide and the opioid system
Authors: Pereira L.M.S. , Lima‐Júnior R.C.P. , Bem A.X.C. , Teixeira C.G. , Grassi L.S. , Medeiros R.P. , Marques‐Neto R.D. , Callado R.B. , Aragão K.S. , Wong D.V.T. , Vale M.L. , Brito G.A.C. , Ribeiro R.A. 
Published: June 2012

AbstractBackgroundSome studies have shown a somatic nociceptive response due to the activation of transient receptor potential A1 channels (TRPA1), which is modulated by the TRPA1 antagonist HC‐030031. However, a few studies report the role of TRPA1 in visceral pain. Therefore, we investigated the participation of TRPA1 in visceral nociception and the involvement of nitric oxide, the opioid system and resident cells in the modulation of these channels.MethodsMice were treated with vehicle or HC‐030031 (18.75–300 mg/kg) before ifosfamide (400 mg/kg), 0.75% mustard oil (50 μL/colon), acetic acid 0.6% (10 mL/kg), zymosan (1 mg/cavity) or misoprostol (1 μg/cavity) injection. Visceral nociception was assessed through the electronic von Frey test or the writhing response. Ifosfamide‐administered mice were euthanized for bladder analysis. The involvement of nitric oxide and the opioid system were investigated in mice injected with ifosfamide and mustard oil, respectively. The participation of resident peritoneal cells in acetic acid‐, zymosan‐ or misoprostol‐induced nociception was also evaluated.ResultsHC‐030031 failed to protect animals against ifosfamide‐induced bladder injury (p > 0.05). However, a marked antinociceptive effect against ifosfamide, mustard oil, acetic acid, zymosan and misoprostol was observed (p < 0.05). Neither L‐arginine (600 mg/kg) nor naloxone (2 mg/kg) could reverse the antinociceptive effect of HC‐030031. The reduction of the peritoneal cell population inhibited the acetic acid and zymosan‐related writhes without interfering with the misoprostol effect.ConclusionsOur findings suggest that the blockade of TRPA1 attenuates visceral nociception by a mechanism independent of the modulation of resident cells, nitric oxide and opioid pathways.
Wogonin induces cross‐regulation between autophagy and apoptosis via a variety of Akt pathway in human nasopharyngeal carcinoma cells
Authors: Chow Shu‐Er , Chen Yu‐Wen , Liang Chi‐Ang , Huang Yao‐Kuan , Wang Jong‐Shyan 
Published: June 2012

AbstractAutophagy as well as apoptosis is an emerging target for cancer therapy. Wogonin, a flavonoid compound derived from the traditional Chinese medicine of Huang‐Qin, has anticancer activity in many cancer cells including human nasopharyngeal carcinoma (NPC). However, the involvement of autophagy in the wogonin‐induced apoptosis of NPC cells was still uninvestigated. In this study, we found wogonin‐induced autophagy had interference on the process of apoptosis. Wogonin‐induced autophagy formation evidenced by LC3 I/II cleavage, acridine orange (AO)‐stained vacuoles and the autophagosome/autolysosome images of TEM analysis. Activation of autophagy with rapamycin resulted in increased wogonin‐mediated autophagy via inhibition of mTOR/P70S6K pathway. The functional relevance of autophagy in the antitumor activity was investigated by annexin V‐positive stained cells and PARP cleavage. Induction of autophagy by rapamycin ameliorated the wogonin‐mediated apoptosis, whereas inhibition of autophagy by 3‐methyladenine (3‐MA) or bafilomycin A1 increased the apoptotic effect. Interestingly, this study also found, in addition the mTOR/P70S6K pathway, wogonin also inhibited Raf/ERK pathway, a variety of Akt pathways. Inactivation of PI3K/Akt by their inhibitors significantly induced apoptosis and markedly sensitized the NPC cells to wogonin‐induced apoptosis. This anticancer effect of Akt was further confirmed by SH6, a specific inhibitor of Akt. Importantly, inactivation of its downstream molecule ERK by PD98059, a MEK inhibitor, also induced apoptosis. This study indicated wogonin‐induced both autophagy and apoptosis through a variety of Akt pathways and suggested modulation of autophagy might provide profoundly the potential therapeutic effect. J. Cell. Biochem. 113: 3476–3485, 2012. © 2012 Wiley Periodicals, Inc.
The role of cancer stem cells and miRNAs in defining the complexities of brain metastasis
Authors: Ali Ashhar S. , Ahmad Aamir , Ali Shadan , Bao Bin , Philip Philip A. , Sarkar Fazlul H. 
Published: June 2012

AbstractResearchers and clinicians have been challenged with the development of therapies for the treatment of cancer patients whose tumors metastasized to the brain. Among the most lethal weapons known today, current management of brain metastases involves multiple therapeutic modalities that provide little, if any, for improving the quality of life and overall survival. Recently the role of cancer stem cells (CSCs) in the development of cancer has been studied extensively, and thus its role in the prognosis, diagnosis, and treatment is now being investigated even in the realm of brain metastasis (BM). Recognizing the molecular make‐up of CSCs as well as understanding the role of these cells in resistance to treatment modalities is expected to benefit cancer patients. Additionally, past decade has witnessed an increase in awareness and understanding of the role of microRNAs (miRNAs) in various cancer types, and the deregulation miRNAs are critically important for the regulation of genes during the development and progression of human malignancies. The role miRNAs in BM is being investigated, and has also shown tremendous promise for future research. In this review, we discuss the problem and lethality of brain metastases and the current state of management, and further provide insight into novel avenues that are worth considering including the biological complexities of CSCs and miRNAs for designing novel therapies. J. Cell. Physiol. 228: 36–42, 2013. © 2012 Wiley Periodicals, Inc.