bluuebunny/crossref_metadata_2025_split huggingface dataset:
UJI TOKSISITAS EKSTRAK ETANOL DAUN KELAPA (Cocos nucifera L.) SEBAGAI KANDIDAT ANTITUMOR DENGAN METODE BRINE SHRIMP LETHALITY TEST (BSLT)
Authors: Ulya Tuhfatul , Halid Musparlin 
Published: May 2024

Tumor merupakan penyakit yang ditandai dengan adanya pembelahan sel yang tidak terkendali. Saat ini, terapi pembedahan dan radioterapi adalah pengobatan tumor yang paling efektif, tetapi tidak efisien ketika sel tumor telah menyebar ke seluruh tubuh (metastasis). Kemoterapi merupakan terapi pilihan untuk sel tumor yang bermetastasis, namun kemoterapi memiliki kelemahan karena tidak hanya mempengaruhi sel tumor, tetapi juga sel sehat yang membelah dengan cepat. Kelapa (Cocos nucifera) merupakan komoditas perkebunan yang potensial karena hampir semua bagian tanamannya dapat dimanfaatkan, tak terkecuali daun kelapa. Namun belum banyak penelitian yang melihat kebermanfaatannya dalam kesehatan. Penelitian ini diawali dengan skrining fitokimia ekstrak etanol daun kelapa. Uji toksisitas dilakukan dengan metode BSLT menggunakan 750 ekor larva Artemia salina yang terbagi dalam 6 kelompok (5 kelompok perlakuan dan 1 kelompok kontrol negatif), dengan konsentrasi ekstrak masing-masing kelompok perlakuan 1000, 500, 250, 125, dan 50 ppm, selanjutnya persen mortalitas larva Artemia salina dihitung setelah 24 jam paparan. Skrining fitokimia ekstrak etanol daun kelapa menunjukkan hasil positif adanya senyawa alkaloid, flavonoid, fenol, dan triterpenoid. Hasil uji toksisitas menunjukkan ekstrak etanol daun kelapa konsentrasi 1000, 500, 250, 125, dan 50 ppm mengakibatkan kematian pada larva Artemia salina. Persen mortalitas tertinggi ditemukan pada konsentrasi ekstrak 1000 ppm (41,33%). Nilai LC50 yang didapatkan sebesar 1621,05 ppm menunjukkan ekstrak etanol daun kelapa tidak cukup toksik untuk berpotensi sebagai kandidat antitumor dan antikanker.
PENDAMPINGAN DIGITALISASI BERKAS REKAM MEDIS GUNA MENDUKUNG KEBERHASILAN IMPLEMENTASI REKAM MEDIS ELEKTRONIK DI RSUP HAJI ADAMALIK MEDAN
Authors: Wahab Bachtiyar - , Sembiring Alfrindo , Apriana Ana , Sembiring Efrata 
Published: May 2024

Rumah sakit telah memprioritaskan penggunaan sistem rekam medis elektronik (RME) untuk meningkatkan efisiensi, akurasi, dan kemudahan akses ke data pasien. Namun, transisi dari rekam medis konvensional ke RME seringkali menimbulkan sejumlah masalah, terutama dalam hal digitalisasi berkas rekam medis yang sudah ada. Manfaat penggunaan Rekam Medis Elektronik (RME) telah diakui secara luas, Salah satu manfaat rekam medis elektronik adalah kemampuannya untuk terus menerus memvalidasi data yang berkualitas, terutama ketika pembuatan dan pengumpulan data dilakukan secara otomatis. Penggunaan RME sebagai solusi berbasis teknologi informasi (TI) untuk meningkatkan pertukaran informasi dan komunikasi antar tenaga kesehatan menjadi lebih efektif karena datanya terintegrasi satu sama lain. Metode penyuluhan dilakukan menggunakan peresentasi dan interaksi kepada pegawai di RSUP Haji Adamalik Medan. Kesimpulan akhir dari kegiatan pengabdian masyarakat ini adalah kegiatan penyuluhan kepada pegawai terhadap pendampingan digitalisasi berkas rekam medis di instalasi RSUP Haji Adamalik Medan.
PERFIL EPIDEMIOLÓGICO DOS CASOS DE TUBERCULOSE NOTIFICADOS NO MUNICÍPIO DE CACOAL E A IMPORTÂNCIA DA ATENÇÃO PRIMÁRIA NA REDUÇÃO DA INFECÇÃO
Authors: Eduardo Lima Oliveira  , Khatlyn Rayeele Evencio da Silva Witcel  , Letícia Stefhanee Zulian Machado  , Jessíca Reco Cruz  
Published: May 2024

A Tuberculose (TB) é considerada uma doença infectocontagiosa causada através das bactérias que compõem o complexo Mycobacterium Tuberculosis, considerada negligenciada no Brasil, a prevalência da doença se dá principalmente em pessoas as em situação de rua, indígenas e privadas de liberdade. O objetivo deste estudo foi identificar as características sociodemográficas e clínicas dos casos de tuberculose notificados no município de Cacoal no período de 2018 a 2018. Foram notificados 95 casos de tuberculose, com maior prevalência em indivíduos do sexo masculino, não brancos, em idade economicamente ativa e com nível de escolaridade menor que 10 anos. Predominou-se a forma pulmonar, o tabagismo, HIV e etilismo não foram considerados estatisticamente significativos neste estudo. O Tratamento Diretamente Observado (TDO) e a baciloscopia foi realizado na maior parte dos casos. Este estudo ressalta a importância da Atenção Primária à Saúde como rede ordenadora do cuidado na redução das taxas de abandono do tratamento e reinfecção da doença, nem como da morbimortalidade por TB no país.
Diagnóstico de rezago académico en estudiantes de nuevo ingreso. tras Pandemia por COVID 19
Authors: Borrego Elías Ana Lourdes Aracely , García Sánchez Eduardo , Godina González Pilar Cecilia , Martínez Ruiz Francisco Javier , Cervantes Viramontes José Manuel , Bañuelos García Luis Eduardo 
Published: May 2024

El propósito de la investigación es conocer los resultados en el aprendizaje de los estudiantes de nuevo ingreso a la Unidad Académica de Ingeniería Eléctrica de la Universidad Autónoma de Zacatecas, como resultado de recibir por más de dos años clases a distancia durante la Pandemia por COVID 19. El muestreo es probabilístico, aleatorio simple, integrado por 150 estudiantes. La crisis sanitaria internacional ocasionada por el virus SARS COV2, afectó las actividades cotidianas, entre ellas la educación. En México fue necesario declarar emergencia sanitaria, se establecieron medidas de sana distancia que incluían la suspensión de clases presenciales en todos los niveles educativos, por lo que la Secretaría de Educación estableció las actividades académicas a distancia a través del uso de las Tecnologías de la Información TICs, debido a lo anterior Pérez Archundía E. 2021, considera que el rezago tecnológico y de alfabetización tecnológica que prevalece en el país, así como la desigualdad social y económica de los estudiantes sería un problema. El estudio pretende conocer las principales dificultades que enfrentaron los estudiantes durante la educación a distancia, en qué materias experimentan más rezago y con base a los resultados proponer una estrategia para su regularización académica.
The JCMT Transient Survey: Six Year Summary of 450/850 μm Protostellar Variability and Calibration Pipeline Version 2.0
Authors: Mairs Steve , Lee Seonjae , Johnstone Doug , Broughton Colton , Lee Jeong-Eun , Herczeg Gregory J. , Bell Graham S. , Chen Zhiwei , Contreras-Peña Carlos , Francis Logan , Hatchell Jennifer , Kim Mi-Ryang , Liu Sheng-Yuan , Park Geumsook , Qiu Keping , Wang Yao-Te , Zhang Xu ,   The JCMT Transient Team
Published: May 2024

Abstract
The James Clerk Maxwell Telescope (JCMT) Transient Survey has been monitoring eight Gould Belt low-mass star-forming regions since 2015 December and six somewhat more distant intermediate-mass star-forming regions since 2020 February with the Submillimeter Common User Bolometer Array 2 on board JCMT at 450 and 850 μm and with an approximately monthly cadence. We introduce our pipeline v2 relative calibration procedures for image alignment and flux calibration across epochs, improving on our previous pipeline v1 by decreasing measurement uncertainties and providing additional robustness. These new techniques work at both 850 and 450 μm, where version 1 only allowed investigation of the 850 μm data. Pipeline v2 achieves better than 0.″5 relative image alignment, less than a tenth of the submillimeter beam widths. The version 2 relative flux calibration is found to be 1% at 850 μm and <5% at 450 μm. The improvement in the calibration is demonstrated by comparing the two pipelines over the first 4 yr of the survey and recovering additional robust variables with version 2. Using the full 6 yr of the Gould Belt survey, the number of robust variables increases by 50%, and at 450 μm we identify four robust variables, all of which are also robust at 850 μm. The multiwavelength light curves for these sources are investigated and found to be consistent with the variability being due to dust heating within the envelope in response to accretion luminosity changes from the central source.
A new species of Corethrella Coquillett (Diptera: Corethrellidae) from Death Valley, California, United States of America
Authors: Borkent Art 
Published: May 2024

Abstract
A new species of frog-biting midge in the genus Corethrella Coquillett from Death Valley National Park, California, United States of America, is described, based on a single female. The species belongs to the rotunda species group, which are otherwise known to have hyporheic larvae. The species is placed phylogenetically within the group, and a modified portion of a Nearctic key is presented. The rotunda species group now contains 13 species, three of which are in the Nearctic, and the remaining 10 of which are in the Neotropical region.
Mycobacterium Tuberculosis Complex in Children Clinical, Radiological Features, Management, Outcome and Susceptibility Pattern
Authors: AlHarthi Waad , Abdullahi Abdulrahim , Bagaber Omar , AlAbbas Doaa , AlBedaie Eman , AlMasoud Mohammad , Abutaleb Nada , Alshahrani Saleh , AlZahrani Mofarah , Alidrisi Eman , AlShahrani Dayel 
Published: May 2024

Introduction

Mycobacterium tuberculosis complex MTC is a major cause of morbidity and mortality globally. The Bacille Calmette-Guérin (BCG) vaccine is most commonly used worldwide. Disseminated BCG disease is one of the vaccine complications that may occur in immunocompromised children.

Methods
Retrospective study from January 2009 to December 2022.

Results
We evaluated 66 patients with microbiologically documented M. tuberculosis complex. Immunocompetent were 28 while 38 were immunocompromised. Our data include 46 patients with BCG-related infections. The majority of 26 patients were diagnosed with disseminated BCGiosis, and local BCGitis was found in 20 out of 46. Remaining 20 patients constitute non-BCG-related infections. Chest radiography done in 58 patients and 10.6% had abnormal findings specific for TB. Other image was mainly done for disseminated BCGiosis. The overall acid-fast bacillus AFB smear was positive in 42.4%, polymerase chain reaction (PCR) positive in 75.8% and positive cultures in 97%. Susceptibility of all samples showed high resistance of pyrazinamide 78.2%, and INH 57.8%, while low resistance to RIF and ethambutol. A further subanalysis of the non-BCG group only showed a drop of resistance to 30% for the related group; all strains were pyrazinamide resistant in the same line with the fact that BCG strain is intrinsically resistant to pyrazinamide, all our patients were 100% resistant. We observed four medications showed some advantage over three-drug regimens with respect to mortality in immunocompromised group. The overall outcome in all patients showed 10.6% mortality. Majority were in disseminated BCGiosis, in which 19.2% died.

Conclusion:
Our center is the main referral hospital in the kingdom with a large number of patients that will help in understanding local data more. Performance of smear and PCR showed variation in relation to different TB diagnoses and sensitivity patterns, giving us insight into different MTB complex strain characteristics that would help in treatment. Sensitivity pattern data will help in keeping updated treatment protocol locally. We recommend managing disseminated BCGiosis with at least four antimycobacterial agents.
Modified Alvarado and Samuel scores: Contribution to the diagnosis of acute appendicitis in the pediatric acute and emergency department
Authors: Tchoumi Josianne , Gruden Enrico , Elenga Narcisse , Kayemba-Kay’s Simon 
Published: May 2024

Introduction
Acute abdominal pain is a common complaint among pediatric patients. Surgical emergencies, particularly acute appendicitis (AA), evoke significant concern due to the challenges associated with its diagnosis.

Objectives
This study aimed to evaluate the contribution of modified Alvarado and Samuel scores (pediatric appendicitis scoring systems) to the diagnosis of AA in children who attended our acute and emergency department.

Study Population and Methods
Children aged 3 to 16 years who presented to the acute and emergency department with acute abdominal pain were included after obtaining parental consent and Ethics Committee approval. Data on the patient’s age, sex, body temperature, history of bowel habits, trauma, weight loss, chronic gastrointestinal disease, etc., were collected. The modified Alvarado and Samuel scores were calculated, and children were classified into three groups: G1 (score <4), G2 (≥4 score <7), and G3 (score ≥7). The diagnostic value of both scores was assessed by calculating their positive predictive value (PPV), negative predictive value (NPV), sensitivity, specificity, positive likelihood ratio (PLR), and negative likelihood ratio (NLR). Children with known chronic inflammatory bowel disease, obvious sepsis, and incomplete case records were excluded.

Results
Of the 90 children recruited for this study, only 87 were included (49 boys, 38 girls, sex ratio: 1.3:1). The overall mean age of the study population was 9.3 years, and the mean ages per group were 9.25 years (G1), 10.3 years (G3), 9.5 years (G3-1), and 7.25 years (G3-2). Of the 87 children, 69 (79%) experienced abdominal pain attributed to a medical cause, and 18 (21%) required surgery [of whom 16 received early intervention, while 2 (G3-1 subgroup) received the intervention after 24 hours of observation]. Of the 16 patients who received early intervention, 6 (38%) who underwent immediate surgery had perforated appendicitis, 4 had suppurated appendicitis, and 6 had simple inflammatory appendicitis. For G3 patients, Alvarado score showed a PPV, an NPV, a sensitivity, a specificity, a PLR, and a NLR of 91.7%, 98%, 91.7%, 98%, 45.5, and 0.09, respectively. For Samuel score, the values were 93%, 98%, 93%, 98%, 46, and 0.08, respectively. The majority of patients with purulent and perforated appendicitis (except 1, score 3) belonged to G3, of whom 1 had a false-positive score (score ≥7) and another had a false-negative score (score 3). Four patients in G3 required abdominal tomodensitometry.

Conclusion
The modified Alvarado and Samuel scoring system is a valuable tool for diagnosing AA in children seeking care at the acute and emergency department.
Assessing The Challenges In Ownership And Funding Practices Of University Education In Cross River State, Nigeria
Authors: Deborah B Onabe , Effiom Eyo Ekpo , Roland Afen Inah , Kazon Shaku 
Published: May 2024

This study explored the challenges in ownership and funding practices of university education in Cross River State, Nigeria. Descriptive survey design was adopted in conducting the study. Three research questions were answered through the data collected from all the Heads of Department in the sampled Universities in Cross River State including University of Calabar (UNICAL) and Cross River State University (CRSU), Havilla University, Nde-Ikom and Arthur Javis University Akpabuyo. The population comprised 228 Heads of Department in the study area. The census approach was adopted in drawing the population because they are manageable. A 20-item validated questionnaire titled: Challenges in Ownership and Funding Practices of University Education Questionnaire (COFPUEQ) was employed for data collection. The instrument was tested for reliability using Cronbach Alpha at a statistical index .86 which was adjudged good enough for data collection. Data collected were analyzed through mean and standard deviation. Findings revealed that the key challenges in ownership and funding practices of universities in the study area include but not limited to insufficient funding, complex bureaucratic processes, inadequate infrastructure, difficulty in attracting and retaining faculty. It was concluded that by examining these challenges and proposing potential strategies for sustainable funding, the study recommends the importance of diversifying funding sources and engaging in public-private partnerships to enhance the financial sustainability of universities in the State.
Impact of Public Domestic Borrowing on Private Sector Investments in Kenya
Authors: Kithandi Charles Katua 
Published: May 2024

In recent there has been rapid increase in uptake of domestic debt by the government of Kenya. The purpose of this study was to establish the Impact of Public Domestic Debt on Private Investments in Kenya. The independent variable was public domestic debt while the dependent variable was private investment. Secondary data on Public domestic debt data and private investment was collected from Central Bank of Kenya. The secondary data was for the periods 1999 to 2021. Private investment was operationalised using Gross fixed capital formation (GFCF) and the study applied Autoregressive distributed lag (ARDL) econometric model. The study found out that the long-term analysis indicated sustained public domestic borrowing had a negative influence on GFCF, revealing a crowding-out effect. This implied that over time, persistent government debt led to reduced private sector investment.
Gear up for safety: Investing in a new automotive future in China
Authors: Sazib Hossain  , Touhidul Islam Nur  
Published: May 2024

China's electric vehicle (EVs) sector has experienced rapid growth over the past five years, driven by the country's ambition to lead in EV technology globally. As the automotive industry evolves, safety measures become increasingly important for manufacturers and consumers alike. The shift towards EVs is reshaping the automotive industry, posing challenges to traditional industry leaders and raising geopolitical concerns. China's emergence as a hub for EV production has supported this change. Evaluating strategies to mitigate the impact of Chinese-made automobiles, considering their cost-effectiveness and competitive advantage, is crucial as China's cars become more affordable and high-quality. Understanding the potential outcomes of investing in safety is crucial for navigating the complexities of the Chinese automotive market and establishing a sustainable presence in the industry. This study examines the potential outcomes of investing in safety in the Chinese automotive landscape, taking into account factors such as the business environment, regulatory landscape, cultural nuances, and market dynamics. It aims to provide direction for new investors and insights for new automotive companies entering the Chinese market, while emphasizing safety standards and innovation.
Keywords: Electric Vehicle, Investment Safety, Business Environment, Regulatory Landscape, Cultural Nuances, Market Dynamics.
Etranacogene Dezaparvovec (Hemgenix)
Authors: CADTH  
Published: May 2024

CADTH recommends that public drug plans reimburse Hemgenix for the treatment of hemophilia B if certain conditions are met.
Hemgenix should only be covered to treat patients (≥ 18 years of age) with moderately severe to severe hemophilia B (circulating coagulation factor IX [FIX] ≤ 2%) if their bleeding requires ongoing prophylactic treatment, their titre of the neutralizing antibody to variant adeno-associated virus 5 (AAV5) is below 1:900, they do not have FIX inhibitors, and if they have not previously received gene therapy to treat hemophilia B.
Hemgenix should only be reimbursed if it is prescribed by specialists who are experts in treating hemophilia B and the cost of Hemgenix is reduced.
Pengaruh Kepuasan Kerja Terhadap Motivasi Pegawai Negeri Sipil Pada Dinas Perindustrian Perdagangan Koperasi Usaha Kecil Dan Menengah Kabupaten Sintang
Authors: Ihsan Zainur 
Published: May 2024

Penelitian ini bertujuan untuk mengetahui pengaruh kepuasan kerja terhadap motivasi pegawai negeri sipil di Dinas Perindustrian Perdagangan Koperasi Usaha Kecil dan Menengah Kab. Sintang. Populasi dalam penelitian ini adalah seluruh PNS pada Dinas Perindustrian Perdagangan Koperasi Usaha Kecil dan Menengah Kabupaten Sintang berjumlah 44 orang dengan menggunakan teknik sampel jenuh. Adapun metode analisis dalam penelitian ini menggunakan analisis regresi linier sederhana. Berdasarkan hasil analisis regresi linier sederhana menunjukkan persamaan regresi yaitu Y = 0,364 + 0,941X. Koefesien korelasi menunjukkan nilai R (koefesien korelasi) sebesar 0,808 maka dapat disimpulkan tingkat hubungan antara kepuasan kerja terhadap motivasi memiliki hubungan yang sangat kuat. Koefesien determinasi menunjukkan nilai R Square sebesar 0,653, hal ini mengandung arti bahwa pengaruh variabel kepuasan kerja terhadap motivasi adalah sebesar 65,3% dan dipengaruhi variabel lain diluar penelitian sebesar 34,7%. Uji kelayakan model menunjukkan nilai Fhitung 79,126 dengan taraf siginifikan sebesar 0,000, sedangkan Ftabel sebesar 4,07 dengan taraf signifikan 0,05. Hal ini dapat disimpulkan bahwa Fhitung > Ftabel, yaitu 79,126 > 4,07, sedangkan taraf signifikansi 0,000 < 0,05, maka dapat disimpulkan bahwa Ha diterima dan Ho di tolak berarti model regresi sederhana dapat digunakan untuk memprediksi motivasi pegawai negeri sipil yang dipengaruhi oleh kepuasan kerja
As proposições políticas do Banco Mundial para o alívio da pobreza na educação infantil
Authors: Bueno Cristiane , Dossena Gisele Aparecida , Scolaro Julian Monike Nazario , Beckert Francielle Selzler Brecher 
Published: May 2024

Este artigo, por meio de pesquisa bibliográfica e documental, tem o propósito de demonstrar a relação entre Educação e Desenvolvimento para o Banco Mundial, a qual está sustentada na defesa de investimento para a satisfação das necessidades humanas básicas para atendimento aos grupos socialmente vulneráveis. Como resultado da análise, as proposições políticas do Banco Mundial para a Educação Infantil tem como prioridade o alívio da pobreza, referência para a formulação de propostas que atendam as necessidades humanas básicas, com ênfase para valorização do capital humano, cujo objetivo é o de aumentar a produtividade futura dos pobres, visando incluí-los no sistema econômico e no mercado de consumo.
Lessico del Comico II 2019-2020
Authors: Caciagli Stefano , De Sanctis Dino , Regali Mario , Giovannelli Maddalena 
Published: May 2024

7 Apuntes para una teoría del insulto di Lucía Rodríguez-Noriega Guillén
17 Poetica e retorica del ‘nuovo’ (καινός) di Andrea Capra, Marina Cavalli
39 Ceci, orzo e mentuccia: gli organi sessuali nella commedia greca di Stefano Caciagli, Dino De Sanctis, Maddalena Giovannelli, Mario Regali
55 Degradazione e desiderio: la maschera della Vecchia sulla scena greca di Stefano Caciagli, Dino De Sanctis, Maddalena Giovannelli, Mario Regali
95 Il gallo dalla commedia al discorso filosofi o e aneddotico: limiti e potenzialità di una fi ura comica di Stefano Caciagli, Dino De Sanctis, Mario Regali
115 Togliersi la maschera: politica e poetica delle parabasi comiche di Stefano Caciagli, Maddalena Giovannelli, Mario Regali