bluuebunny/crossref_metadata_2025_split huggingface dataset:
CPL of Mellein and Related Natural Compounds: Analysis of the ESIPT Phenomenon
Authors: Mazzeo Giuseppe , Fusè Marco , Bloino Julien , Evidente Antonio , Abbate Sergio , Longhi Giovanna 
Published: June 2024

Abstract(R)‐(−)‐Mellein, (3R,4R)‐4‐hydroxymellein and (3R,4S)‐4‐hydroxymellein obtained from fungi, i. e. from Diplodia globulosa, were investigated as a class of natural products presenting ESIPT (excited state intramolecular proton transfer) phenomenon, through fluorescence and CPL (circularly polarized luminescence). The study was preceded by the assessment of the absolute configuration through ECD and VCD (electronic and vibrational circular dichroism) spectroscopies in addition to NMR spectra. It is found that ESIPT takes place in these systems very rapidly, and no dual fluorescence has been observed. The experimental study is backed up by TD‐DFT calculations of ECD and CPL spectra, plus MD calculations to follow proton transfer in the excited state and careful analysis of the puckering dynamics of the lactone ring. Deprotonated forms of the three compounds were also investigated by the same chiroptical experimental and theoretical methods, showing how one can find in natural compounds not only biological activity but also biologically compatible sensing probes.
A Review on the Zone Refining Process Technology toward Ultra‐Purification of Gallium for GaAs/GaN‐based Optoelectronic Device Applications
Authors: Ghosh Kaustab , Mani V. N. 
Published: June 2024

AbstractUltrapure gallium up to 99.9999%/ 99.99999% (6N/7N) purity level is a highly demanding material needed for the growth of gallium‐based group III–V semiconductor compounds and optoelectronic devices. However, general extraction of gallium from Bayer liquor contains high impurity content and ultra‐purification of the same cannot be accomplished by a single step. Thus, the purpose of this review is to assess various purification processes for the production of ultra‐pure gallium and to critically examine its applications in the optoelectronics industry. Through this research survey, it is found that zone refining of the zone melting process stands tall over other methods in purifying materials even up to 13N. Hence, scientists are adopting detailed mathematical models and simulation tools for designing unique zone refining systems for material purification. Current‐day technology even adopts intelligence methods such as machine learning, which sheds light on the importance of different zone refining parameters that influence the purification process. Here, the practical aspects of zone refining and how the feedback from the theoretical models or performance prediction through intelligence methods can be effectively incorporated into practice have also been emphasized
Evaluating global research trends in special needs dentistry: A systematic bibliometrix analysis
Authors: Senthilvadevel Nigashiny , Ky Jimmy , Ng Matthew , Zhao Tong , Aria Massimo , D'Aniello Luca , Lim Mathew A. W. , Canfora Federica , Fortuna Giulio , McCullough Michael , Yap Tami , Paolini Rita , Celentano Antonio 
Published: June 2024

AbstractObjectivesSpecial needs dentistry (SND) is a vast and fragmented field of study. This comprehensive bibliometric analysis aimed to evaluate the scope of SND, including the existing knowledge base, distribution structure, quantitative relationships, and research trends.Material and MethodsA systematic search was conducted on March 10, 2022, using the Web of Science Core Collection database, covering the period from 1985 to 2021, focusing on studies reporting on special needs populations in a dentally relevant context. Records were title‐screened and analyzed for key bibliometric indicators.ResultsAmong 48,374 articles, 13,869 underwent bibliometric analysis. Peak SND research occurred during 1985–1997. United States led in productivity, trailed by Brazil and Japan. University of Sao Paulo excelled in Brazil, University of Washington and University of North Carolina in the United States. The Journal of Dental Research was the most productive source of research and also had the highest number of citations, followed by Community Dentistry and Oral Epidemiology. Keyword analysis revealed that “elderly”, “caries”, and “epidemiology” were the most commonly used author keywords.ConclusionsThis study represents the first bibliometric analysis of SND literature. It emphasizes the need for increased collaboration between institutions and authors. Furthermore, it suggests focusing on research input from non‐dental disciplines and populations with rarer intellectual or developmental conditions.
An In Vitro Evaluation of Periotest Implant Stability Measurements Taken on Implant Retained Crowns and Healing Abutments
Authors: O'Brien Cianna , Naughton David , Honari Bahman , Winning Lewis , Polyzois Ioannis 
Published: June 2024

ABSTRACTObjectiveTo assess the reliability of implant stability measurements recorded with the Periotest device and to investigate the differences in values when these measurements were taken on implant retained crowns and healing abutments.Materials and MethodsFifty‐six implants in eight synthetic bone blocks were used to carry out implant stability measurements using the Periotest device by two different operators. Each block constituted an example of bone of density D1, D2, D3, or D4, and two blocks of each density were used. The healing abutments placed were of a height to allow approximately 6 mm of the implant‐abutment complex to be supracrestal and temporary crowns were made to match the dimensions of an average central incisor. Descriptive statistics were used to describe the perio test values (PTVs) at each of the different heights on the implant abutments and implant crowns. Means for each site were calculated and distribution of data assessed using the Kruskal Wallis test. The interclass correlation coefficient (ICC) was used to determine the relationship between the PTVs recorded on the implant abutments and implant crowns.ResultsThe mean PTV (±standard devidation) recorded across all sites was 5.57 ± 11.643 on the implant abutments, and 12.27 ± 11.735 on the temporary crowns. Excellent/good inter‐operator ICCs were recorded for the mid‐abutment site in all bone blocks D1–D4 (ICC = 0.814, p < 0.001, ICC = 0.922, p < 0.001, ICC = 0.938, p < 0.001, ICC = 776, p < 0.001). For mid crown sites, ICC between operators was excellent/good only for recordings in D2 bone (ICC = 0.897, p < 0.001).ConclusionsPeriotest device seems to be able to reliably measure implant stability across all types of bones when the implant stability is assessed at approximately 3 mm coronal to the implant platform for abutments and 4.5 mm for implant supported single crowns.
Reliability‐based resilience assessment method for mooring systems under mooring failure
Authors: Yu Yang , Zhang Wenhao , Zhang Baolei , Wu Jingyi 
Published: June 2024

AbstractOffshore floating structures rely heavily on their mooring systems, which can be disrupted by various events during long‐term operation. These could lead to a mooring failure, affecting the usual operations of the structure or even causing more severe hazards. Resilience provides a comprehensive evaluation of how the mooring system performs after a disaster, which is key to optimizing the structural design and operational safety. In this paper, we develop a general and user‐friendly method to quantitatively assess the resilience of mooring systems under mooring failure. We use the reliability index to represent the performance of the mooring system. We then derive its RV, ACI, and RCI, which are based on a system performance curve and reliability analysis. We also consider the effects of climate change and the corrosion of the mooring chain. These factors can significantly affect environmental loads, structural performance, and the recovery process. Moreover, an illustrative example is provided that guides us through the methodology. The proposed method is applied to assess the resilience of a certain mooring system in the South China Sea over a 30‐year service life under different failure scenarios. Our results indicate that overlooking climate change in the design and operation of the mooring system can lead to a significant overestimation of its reliability index and resilience value.
Dual function of formamidinium chloride additive improves the efficiency and stability of low‐dimensional perovskite solar cells
Authors: Yang Lvpeng , Bie Tong , Ma Peiyu , Xin Jin , Nguyen Tho D. , Shao Ming 
Published: June 2024

AbstractDespite their excellent intrinsic stability, low‐dimensional Ruddlesden‐Popper (LDRP) perovskites face challenges with low power conversion efficiency (PCE), primarily due to the widen bandgap and limited charge transport caused by the bulky spacer cation. Herein, we introduce formamidinium chloride (FACl) as an additive into (4‐FPEA)2MA4Pb5I16 perovskite. On the one hand, the addition of FACl narrows the bandgap through cation exchange between MA+ and FA+, thereby extending the light absorption range and enhancing photocurrent generation. On the other hand, this MA+/FA+ cation exchange decelerates the sublimation of methylammonium chloride and prolongs the crystallization of LDRP perovskite, leading to higher crystallinity and better film quality with a decreased trap‐state density. Consequently, this approach led to a remarkable PCE of 20.46% for <n> = 5 LDRP perovskite solar cells (PSCs), ranking among the highest for MA/FA mixed low dimensional PSCs reported to date. Remarkably, our PSCs maintained 90% and 92% of the initial efficiency even after 1300 h at (60 ± 5)°C and (60 ± 5)% relative humidity, respectively. This work promotes the development of LDRP PSCs with excellent efficiency and environmental stability for potential commercial application.
Edible‐plant derived 2′,4′‐dihydroxy‐6′‐methoxy‐3′,5′‐dimethylchalcone exert dual effects on invigorating triple‐negative breast cancer apoptosis
Authors: Yu Tingting , Jiang Yu , Guo Miaomiao , Wei Xing , Xin Xiujuan , An Faliang 
Published: June 2024

Abstract2′,4′‐Dihydroxy‐6′‐methoxy‐3′,5′‐dimethylchalcone (DMC) is a typical and abundant chalcone compound from the buds of Cleistocalyx operculatus, which is well‐known for its edible and medicinal qualities. In this study, DMC showed effective cell cycle arrest at G2/M on MDA‐MB‐231 cells, though dual impacts, including the inhibition of microtubule polymerization through binding to β‐tubulin and the stimulation of reactive oxygen species (ROS) production by inhibiting catalase activity. The increased ROS level inhibited PI3K/Akt/mTOR pathway and further suppressed the expression level of Cdc2, Cdc25C, and Cyclin B1, alongside stimulated the expression level of p21 and p27. Above 29.5% MDA‐MB‐231 cells were arrested at G2/M phase, subsequently undergoing apoptosis due to heightened levels of apoptosis‐related proteins Bax and caspase 3. In summary, this study demonstrated that DMC concomitantly plays dual roles in apoptotic inducing by inhibiting the ROS consumption and microtubules formation in triple‐negative breast cancer cells.
Anticancer potential of Diospyrin and its analogues: An updated review
Authors: Rauf Abdur , Akram Zuneera , Hafeez Nabia , Khalil Anees Ahmed , Khalid Ahood , Hemeg Hassan A. , Aljohani Abdullah S. M. , Al Abdulmonem Waleed , Quradha Mohammed Mansour , Qahtan Abdulkader Moqbel Farhan 
Published: June 2024

AbstractCancer, characterized as one of the leading causes of death owing to its heterogeneity and complexity, hence poses a significant challenge to health care system across the globe. Current therapies for cancer curtailment are considered to have associated side effects, therefore discovery of novel alternative approaches is need of the time. In this context, natural products have attained an essential spot in the scientific community for the development of novel cancer treatments. Among others, Diospyrin, a bis‐hydroxy‐naphthoquinonoid, is a vital bioactive component present in various Diospyros and Euclea species. The bioactivity associated with Diospyrin's makes it a promising “lead molecule” for new chemotherapy. In this review, biosynthesis of Diospyrin and its analogues along with their anticancer activities has been discussed. Moreover, this review briefly discusses probable modes of action of Diospyrin and its analogues by targeting the molecular signal transduction pathways. This review also highlights the toxicological and clinical implications of diospyrin and its derivatives. Further pharmacological and pharmacogenetic studies are required to better understand the anticancer potential of Diospyrin and its analogues at the molecular and genetic levels.
Preventive effects of Chinese Xinjiang naturally fermented yogurt separated from Lactobacillus rhamnosusAFY02 on acute gouty arthritis in mice
Authors: Wang Mengwei , Fan Yang , Song Jing , Liu Yanqing , Liu Bihui , Zhao Xin , Wu Wenzhong 
Published: June 2024

AbstractLactobacillus rhamnosus AFY02 (LR‐AFY02) is a newly discovered strain isolated and identified from naturally fermented yogurt in Xinjiang, China. This research aims to investigate the mechanism of action of LR‐AFY02 in mice with acute gouty arthritis. We examined the degree of foot swelling, pain threshold, blood biochemical indicators, histopathological changes, and mRNA expression. LR‐AFY02 can decrease the severity of mouse foot edema and raise the pain threshold. LR‐AFY02 can increase the enzyme activity of superoxide dismutase (SOD) and the level of glutathione (GSH) while lowering the enzyme activity of myeloperoxidase (MPO) and the level of malondialdehyde (MDA) in mice with acute arthritis. Interleukin‐6 (IL‐6), IL‐10, interleukin‐1 beta (IL‐1β), and tumor necrosis factor‐alpha (TNF‐α) levels in the blood of mice with acute arthritis are also decreased by LR‐AFY02. Histopathological findings demonstrated that LR‐AFY02 reduced tissue damage in the mouse foot and ankle joints. LR‐AFY02 may suppress the mRNA expression of extracellular signal‐regulated kinase 1/2 (ERK1/2), cyclooxygenase‐2 (COX‐2), prostaglandin E2 (PGE2), IL‐6, interferon gamma (IFN‐γ), and TNF‐α in the tissues of the ankle joints of mice with acute arthritis. Additionally, LR‐AFY02 has the ability to increase the expression of catalase (CAT), manganese superoxide dismutase (Mn‐SOD), and copper/zinc superoxide dismutase (Cu/Zn‐SOD). As a result, it is clear that L. rhamnosus AFY02 is more effective than glucosamine sulfate at preventing acute gouty arthritis.
Trans, trans‐2,4‐decadienal, a lipid peroxidation product, aggravates insulin resistance in obese mice by promoting adipose inflammation
Authors: Hu Yuanyuan , Zeng Xiangbo , Luo Ying , Pei Xuechen , Zhou Dayong , Zhu Beiwei 
Published: June 2024

AbstractPeroxidation of polyunsaturated fatty acids results in the creation of numerous α, β‐unsaturated aldehydes, many of which are complicated by the development of diabetes. Trans, trans‐2,4‐decadienal (DDE) is a dietary α, β‐unsaturated aldehyde that is commonly found in food and the environment. However, it is unknown whether DDE exposure has some negative effects on glucose homeostasis and insulin sensitivity. This study investigated the biological effects of long‐term DDE exposure in normal chow diet (NCD)‐fed non‐obese mice and high‐fat diet (HFD)‐fed obese mice. Results showed that oral administration of DDE for 14 weeks did not cause severe toxicity in NCD‐fed non‐obese mice but had significant adverse effects in HFD‐fed obese mice. It was found that DDE exposure caused significant increases in LDL and ALT levels and aggravated glucose intolerance and insulin resistance in obese mice. Moreover, DDE robustly accumulated in adipose tissue and promoted the impairment of the insulin signaling pathway in the adipose tissue of obese mice while not affecting the skeletal muscle or liver. Mechanistically, DDE aggravated adipose tissue inflammation by promoting M1 macrophage accumulation and increasing proinflammatory cytokines in the adipocytes of obese mice, thus leading to impaired systemic insulin resistance. These findings provide crucial insights into the potential health impacts of long‐term DDE exposure.
The accurate digitization of historical sea level records
Authors: McLoughlin Patrick J. , McCarthy Gerard D. , Nolan Glenn , Lawlor Rosemarie , Hickey Kieran 
Published: June 2024

AbstractUnderstanding regional sea level variations is crucial for assessing coastal vulnerability, with accurate sea level data playing a pivotal role. Utilizing historical sea level marigrams can enhance datasets, but current digitization techniques face challenges such as bends and skews in paper charts, impacting sea level values. This study explores often‐overlooked issues during marigram digitization, focusing on the case study of Dún Laoghaire in Ireland (1925–1931). The methodology involves digitizing the original marigram trace and underlying grid to assess offsets at the nearest ft (foot) interval on the paper chart, corresponding to changes in the water level trace for each hour interval. Subtracting the digitized value from the known value (the actual measurement) allows for the determination of differences, which are then subtracted from each hourly trace value. After adjusting for offsets ranging from −3.962 to 13.716 mm (millimetres), the study improves the final accuracy of sea level data to approximately the 10 mm level. Notably, data from 1926 and 1931 exhibit modest offsets (<7 mm), while other years show more substantial offsets (>9–14 mm), emphasizing the importance of adjustments for accuracy. Such 10 mm accuracy is compatible with requirements of the Global Sea Level Observing System. Comparing the adjusted digitized data with other survey data shows similar amplitudes and phases for Dún Laoghaire in both the historical and modern datasets, and there is an overall mean sea level rise of 1.5 mm/year when combined with the available data from the Dublin region.
Prognostic implications of mucosal and deep margin distances according to T‐status in oral tongue squamous cell carcinoma: A single‐center retrospective study
Authors: Poissonnet Valentine , Segier Bertille , Lopez Raphaël , Siegfried Aurore , Dupret‐Bories Agnès , Sarini Jérôme , Poulet Vinciane , Delanoë Franck , Vergez Sébastien , Chabrillac Emilien 
Published: June 2024

AbstractObjectiveTo elucidate the prognostic implications of mucosal and deep margin distances in oral tongue squamous cell carcinoma (OTSCC), and to assess a different margin cut‐off value in T1‐T2 versus T3‐T4 tumors.MethodsThis single‐center retrospective study included 223 patients who received surgery for a primary OTSCC between January 2017 and December 2021.ResultsMultivariable analysis showed that deep margin distance ≥3 mm in T1‐T2 tumors and ≥5 mm in T3‐T4 tumors was significantly associated with better RFS and OS. Mucosal and deep margin distances were globally clinically useful for 2‐year RFS prediction of T1‐T2 tumors, for which deep margins seemed to have more clinical utility than mucosal margins. The influence of margin distances on 2‐year RFS seemed greater for T1‐T2 tumors than T3‐T4 tumors.ConclusionMucosal and deep margin distances were associated with OS and RFS in OTSCC. Shorter deep margin distances may be aimed for in T1‐T2 versus T3‐T4 tumors.
Resources for action and organizational resilience in times of COVID‐19: A study in health care
Authors: Righi Angela Weber , Wachs Priscila , Ransolin Natália , Bertoni Vanessa Becker 
Published: June 2024

AbstractThe COVID‐19 pandemic challenged health care organizations to cope with major disruptions, especially in the first waves. Several investigations were undertaken to understand how to support resilience during similar unexpected events. In this study, we attempted to unveil the resilient performance of health care organizations during the first waves of the COVID‐19 pandemic from the viewpoint of resources for action. Thus, the research objectives are twofold: (i) to evaluate organizational resilience in facing COVID‐19 by hospitals in Brazil and (ii) to evaluate the relationship between resources for action and resilient performance. Firstly, an online survey was sent to front‐line health care workers, resulting in 111 responses. Then, a questerview was undertaken through online interviews with some participants of the previous phase. Resources for action were interpreted as five aspects supporting decision‐making in health care organizations: information and communication; team, equipment, and tools; standard operating procedure (SOP); training; and built environment. Each resource was then unfolded based on the four potentials for resilient performance (i.e., anticipate, monitor, respond and learn). Respondents strongly agreed that their institutions are resilient (M = 4.15; standard deviation [SD] = 0.91). The potentials to learn (M = 4.23; SD = 0.96) and respond (M = 4.08; SD = 1.02) stood out, followed by monitoring (M = 3.85; SD = 1.07) and anticipating (M = 3.70; SD = 1.11). Although some differences stand out, findings corroborate with the joint performance of the resources for action to support resilience performance. Information and communication were the most present among the resources for action (M = 4.20). Making resources for action visible is a strategy for designing resilient systems, as it can be considered a bridge linking different resilience levels (micro, meso, and macro). Suggestions for future studies point out the need to promote the development and evaluation of resources for action in health care institutions.
Electrokinetically controlled mixed convective heat flow in a slit microchannel
Authors: Hamza Muhammed M. , Shehu Abubakar , Muhammad Ibrahim , Ojemeri Godwin , Shuaibu Abdulsalam 
Published: June 2024

AbstractThis study performs a time‐dependent analysis of mixed convection of an incompressible fluid and heat sink/source factor in an upstanding slit superhydrophobic (SHO) microchannel in the involvement of temperature jump and electroosmotic flow conditions. The internal wall of one of the sides in the microchannel is intentionally modified to demonstrate SHO slip and temperature jump conditions. A transverse magnetic effect is introduced in the path of the flow. The steady‐state solutions of the modeled problem have been analytically derived for temperature, velocity, pressure gradient, sheer stress, and heat transfer rate. The derived results are expounded thoroughly with the use of several plots. It is deduced that the elevating mixed convection (Gre), heat source/sink (Qs), Debye–Hückel (K), and nonlinear parameters (N) are observed to increase the fluid flow as time rises, and these effects are all higher when the velocity slip and temperature jump impacts are present. Further, the application of heat‐generating parameters is viewed to encourage the fluid temperature in the microchannel. Finally, the comparison between the current investigation with the previously published findings demonstrates a very good consistency for the limiting cases.