bluuebunny/crossref_metadata_2025_split huggingface dataset:
A three‐dimensional in vitro ovarian cancer coculture model using a high‐throughput cell patterning platform
Authors: Xu Feng , Celli Jonathan , Rizvi Imran , Moon Sangjun , Hasan Tayyaba , Demirci Utkan 
Published: February 2011

AbstractIn vitro 3D cancer models that provide a more accurate representation of disease in vivo are urgently needed to improve our understanding of cancer pathology and to develop better cancer therapies. However, development of 3D models that are based on manual ejection of cells from micropipettes suffer from inherent limitations such as poor control over cell density, limited repeatability, low throughput, and, in the case of coculture models, lack of reproducible control over spatial distance between cell types (e.g., cancer and stromal cells). In this study, we build on a recently introduced 3D model in which human ovarian cancer (OVCAR‐5) cells overlaid on Matrigel™ spontaneously form multicellular acini. We introduce a high‐throughput automated cell printing system to bioprint a 3D coculture model using cancer cells and normal fi broblasts micropatterned on Matrigel™. Two cell types were patterned within a spatially controlled microenvironment (e.g., cell density, cell‐cell distance) in a high‐throughput and reproducible manner; both cell types remained viable during printing and continued to proliferate following patterning. This approach enables the miniaturization of an established macro‐scale 3D culture model and would allow systematic investigation into the multiple unknown regulatory feedback mechanisms between tumor and stromal cells and provide a tool for high‐throughput drug screening.
Deep wells integrated with microfluidic valves for stable docking and storage of cells
Authors: Jang Yun‐Ho , Kwon Cheong Hoon , Kim Sang Bok , Selimović šeila , Sim Woo Young , Bae Hojae , Khademhosseini Ali 
Published: February 2011

AbstractIn this paper, we describe a microfluidic mechanism that combines microfluidic valves and deep wells for cell localization and storage. Cells are first introduced into the device via externally controlled flow. Activating on‐chip valves was used to interrupt the flow and to sediment the cells floating above the wells. Thus, valves could be used to localize the cells in the desired locations. We quantified the effect of valves in the cell storage process by comparing the total number of cells stored with and without valve activation. We hypothesized that in deep wells external flows generate low shear stress regions that enable stable, long‐term docking of cells. To assess this hypothesis we conducted numerical calculations to understand the influence of well depth on the forces acting on cells. We verified those predictions experimentally by comparing the fraction of stored cells as a function of the well depth and input flow rate upon activation of the valves. As expected, upon reintroduction of the flow the cells in the deep wells were not moved whereas those in shallow wells were washed away. Taken together, our paper demonstrates that deep wells and valves can be combined to enable a broad range of cell studies.
ChemInform Abstract: New Oxides Showing an Intense Blue Color Based on Mn3+ in Trigonal‐Bipyramidal Coordination.
Authors: Mizoguchi Hiroshi , Sleight Arthur W. , Subramanian M. A. 
Published: February 2011

AbstractIntroduction of Mn3+ into the trigonal‐bipyramidal sites of ScAlMgO4, ScGaMgO4, LuGaMgO4, ScGaZnO4, LuGaZnO4, and LuGaO3(ZnO)2 with YbFe2O4‐related structures is achieved by solid state reactions of M2O3 (M: Mn, Sc, Lu, Al, Ga), MgO and ZnO (1000 °C for 5 h, 1350 °C for 2 h).
ChemInform Abstract: Novel Method for Preparing NH4NiPO4·6H2O: Hydrogen Bonding Coacervate Selective Self‐Assembly.
Authors: Wu Wenwei , Li Shushu , Wu Xuehang , Liao Sen , Cai Jinchao 
Published: February 2011

AbstractThe title compound is synthesized for the first time by room temperature solid state reaction of NiSO4·6H2O and (NH4)3PO4·3H2O in the presence of polyethylene glycol PEG‐400 surfactant (grinding, 40 min).
ChemInform Abstract: Di(1H,1H,2H,2H‐perfluorooctyl)‐dibenzo‐18‐crown‐6: A “Light Fluorous” Recyclable Phase Transfer Catalyst.
Authors: Gourdet Benoit , Singh Kuldip , Stuart Alison M. , Vidal Jose A. 
Published: February 2011

AbstractThe title crown ether is shown to be a stable and robust PTC catalyst which can be easily recycled by fluorous solid‐phase extraction.
ChemInform Abstract: Michael Adduct: Synthons for a New Class of Heterocycles.
Authors: Padmaja A. , Payani T. , Muralikrishna A. , Padmavathi V. 
Published: February 2011

AbstractWith a view to obtaining biologically interesting heterocycles, the new class of the heterocyclic compounds (IV), (V), (VII), (IX), and (XI) are prepared by using facile, simple and well established synthetic methods.
ChemInform Abstract: 2‐Aroylhexanones in the Synthesis of Azoles.
Authors: Mikhailovskii A. G. , Aliev Z. G. , Bazina N. G. , Pantyukhin A. A. , Vakhrin M. I. 
Published: February 2011

Abstract2‐Aroylhexanones (I) smoothly react with hydrazine, hydroxylamine and o‐phenylenediamine to give indazole (II), benzisoxazole (III) or spiro‐benzimidazole derivatives (V), respectively.
ChemInform Abstract: Development of the Ireland—Claisen Rearrangement of Alkoxy‐ and Aryloxy‐Substituted Allyl Glycinates.
Authors: Tellam James P. , Carbery David R. 
Published: February 2011

AbstractThe title rearrangement of glycinates of type (IV) allows a new and highly stereoselective access to syn‐β‐alkoxy‐α‐amino acid derivatives.
ChemInform Abstract: Preparation and Reactivity of Polystyrene‐Supported Iodosylbenzene Sulfate: An Efficient Recyclable Oxidizing System.
Authors: Chen Jiang‐Min , Zeng Xiao‐Mei , Zhdankin Viktor V. 
Published: February 2011

AbstractAlcohols, sulfides, and triphenylphoshine are efficiently oxidized.
ChemInform Abstract: Highly Efficient Two‐Step Synthesis of (Z)‐2‐Halo‐1‐iodoalkenes from Terminal Alkynes.
Authors: Chen Zhengwang , Jiang Huanfeng , Li Yibiao , Qi Chaorong 
Published: February 2011

AbstractThe easily accessible haloalkynes (I) are converted to (Z)‐2‐halo‐1‐iodoalkenes (II) in high yields and with excellent regio‐ and stereoselectivity.
ChemInform Abstract: Diastereoselective Access to trans‐2‐Substituted Cyclopentylamines.
Authors: Joosten Antoine , Lambert Emilie , Vasse Jean‐Luc , Szymoniak Jan 
Published: February 2011

AbstractA tandem hydrozirconation/Lewis acid mediated cyclization of butenyl substituted oxazolidines allows the synthesis of the target compounds.
ChemInform Abstract: Microwave‐Assisted Zeolite Catalyzed Claisen Rearrangement of Allyl Aryl Ethers under Solvent‐Free Conditions.
Authors: Deodhar Deepak K. , Tipnis Amol S. , Samant Shriniwas D. 
Published: February 2011

AbstractThe reaction is carried out under solvent‐free conditions by means of a reusable and cheap catalyst.
ChemInform Abstract: Catalytic Enantioselective Fluorination of α‐Chloro‐β‐keto Esters in the Presence of Chiral Nickel Complexes.
Authors: Kang Seung Hee , Kim Dae Young 
Published: February 2011

AbstractThe esters (Ia‐c) and dione (Id) with Selectfluor is promoted by a chiral nickel complex under mild conditions.
ChemInform Abstract: Aerobic Photooxidation of Benzylamide under Visible Light Irradiation with a Combination of 48% aq HBr and Ca(OH)2.
Authors: Tada Norihiro , Ban Kazunori , Yoshida Momoko , Hirashima Shin‐ichi , Miura Tsuyoshi , Itoh Akichika 
Published: February 2011

AbstractOptimized reaction conditions are developed and the required diacylamines are obtained in the presence of Ca(OH)2 or Mg(OH)2.
ChemInform Abstract: Divergent Preparation of Fluoroalkylated Sulfilimine and Sulfilimino Iminium Salts.
Authors: Urban Celine , Mace Yohan , Cadoret Frederic , Blazejewski Jean‐Claude , Magnier Emmanuel 
Published: February 2011

AbstractThe preparation of fluoromethyl N‐acyl sulfimides (III) is achieved by reaction of sulfoxide (I) with various nitriles (II).
ChemInform Abstract: Josiphos‐Catalyzed Asymmetric Homodimerization of Ketoketenes.
Authors: Ibrahim Ahmad A. , Wei Pei‐Hsun , Harzmann Gero D. , Kerrigan Nessan J. 
Published: February 2011

AbstractIt is found that Josiphos‐type catalysts efficiently promote enantioselective homodimerization of various ketoketenes including o‐substituted arylalkylketenes and dialkylketenes to give highly substituted β‐lactones.
ChemInform Abstract: Coupling/Cyclization of 1,6‐Enynes with Aryl Halides: An Efficient and General Route for the Synthesis of Functionalized Hexahydroindole and Hexahydrobenzofuran Derivatives.
Authors: Meng Tuan‐jie , Hu Yi‐min , Sun Yong‐jie , Zhu Tao , Wang Shaowu 
Published: February 2011

AbstractThe process allows the direct construction of multiple new carbon—carbon bonds to give the heterocyclic title skeletons with exclusive (E)‐configuration at the side chain.
ChemInform Abstract: Reaction of Diaryl‐1,2‐diones with Homophthalic Anhydride: Efficient Formation of Isobenzofuranone Derivatives.
Authors: Nair Vijay , Paul Rony Rajan , Suresh Eringathodi 
Published: February 2011

AbstractHomophthalic anhydride (I) undergoes reactions with benzils (II) under neat conditions yielding the isobenzofuranones (III) as a diastereomeric mixture.
ChemInform Abstract: Cross‐Coupling of 4,5,6,7‐Tetrahydroindole with Functionalized Haloacetylenes on Active Surfaces of Metal Oxides and Salts.
Authors: Sobenina L. N. , Tomilin D. N. , Petrova O. V. , Gulia N. , Osowska K. , Szafert S. , Mikhaleva A. I. , Trofimov B. A. 
Published: February 2011

AbstractThe solvent‐free reaction of tetrahydroindoles (I) with bromoacetylenes (II) in the presence of different oxides and salts is studied.
ChemInform Abstract: Sulfur‐Containing Heterocycles. Part 14. New Synthesis of Cyclic Anhydrides of 3‐Sulfinocarboxylic Acids
Authors: Vasil'eva T. P. , Shchetnikov G. T. , Osipov S. N. 
Published: February 2011

Abstractvia cyclization of corresponding 3‐chlorosulfinylalkanoyl chlorides under action of sodium or mercury acetate
ChemInform Abstract: Synthesis of New 1,2,4‐Triazole[3,4‐b][1,3,4]thiadiazoles Bearing Pyrazole as Potent Antimicrobial Agents.
Authors: Reddy Cherkupally Sanjeeva , Rao Lade Sanjeeva , Kumar Gaddam Rajesh , Nagaraj Adki 
Published: February 2011

AbstractNovel 1,2,4‐triazole[3,4‐b]thiadiazoles (VI) (10 examples) are synthesized and tested for their in vitro activities against certain strains of bacteria and fungi.
ChemInform Abstract: Suzuki—Miyaura Cross‐Coupling of 3‐Pyridyl Triflates with Alk‐1‐enyl‐2‐pinacol Boronates.
Authors: Vyvyan James R. , Dell Jennifer A. , Ligon Toby J. , Motanic Kelsey K. , Wall Hayley S. 
Published: February 2011

AbstractThe title reaction proceeds smoothly providing the cross‐coupled products (III) in moderate to good yields.
ChemInform Abstract: Synthesis of 4‐Aryl‐2,7,7‐trimethyl‐5‐oxo‐N‐phenyl‐1,4,5,6,7,8‐hexahydroquinoline‐3‐c arboxamides (IV)
Authors: Gein V. L. , Kazantseva M. I. , Kurbatova A. A. , Vahrin M. I. 
Published: February 2011

Abstractvia a four‐component reaction under solvent‐free conditions
ChemInform Abstract: An Intramolecular PIFA‐Mediated Metal‐Free Allylic Oxycarbonylation Reaction and Its Application to the Preparation of Furopyrimidinones.
Authors: Couto Irantzu , Tellitu Imanol , Dominguez Ester 
Published: February 2011

AbstractThe title reaction provides a new and straightforward approach to title compounds of biological interest.
ChemInform Abstract: A One‐Pot Synthesis of Isoxazolyl Benzo[b][1,4]oxazin‐3(4H)‐ones via Smiles Rearrangement.
Authors: Rajanarendar E. , Reddy M. Nagi , Murthy K. Rama 
Published: February 2011

AbstractA simple synthesis of biologically interesting compounds is presented from readily available starting materials.
ChemInform Abstract: Total Synthesis of Enokipodins A—D and Cuparene‐1,4‐diol.
Authors: Srikrishna A. , Rao M. Srinivasa 
Published: February 2011

AbstractThe key intermediate (VIII) in the synthesis of enokipodin A (X), B (XI), C (XIII), D (XII) and cuparene‐1,4‐diol (XIV) is prepared via Claisen rearrangement and ring closing metathesis reaction as the key steps.
ChemInform Abstract: Schefflerins A—G, New Triterpene Glucosides from the Leaves of Schefflera arboricola
Authors: Zhao Zhimin , Matsunami Katsuyoshi , Otsuka Hideaki , Shinzato Takakazu , Takeda Yoshio , Kawahata Masatoshi , Yamaguchi Kentaro 
Published: February 2011

Abstractisolation and structure elucidation of six new lupane glucosides as well as the new dammarane glucisode (IV)
ChemInform Abstract: A Novel Cyclopentene Derivative and a Polyhydroxylated Steroid from a South China Sea Gorgonian Menella sp.
Authors: Chai Xing‐Yun , Sun Jian‐Fan , Tang Li‐Ying , Yang Xian‐Wen , Li Yun‐Qiu , Huang Hui , Zhou Xue‐Feng , Yang Bin , Liu Yonghong 
Published: February 2011

AbstractA highly oxygenated racemate with C8 skeleton, menellin A (I), and a polyhydroxylated steroid, menellsteroid C (II) are isolated as along with eight known natural products.
ChemInform Abstract: Two New Flavan‐Flavanones from Sarcandra hainanensis.
Authors: Cao Cong‐Mei , Xu Li‐Jia , Peng Yong , Shi Qing‐Wen , Xiao Pei‐Gen 
Published: February 2011

AbstractSarcandrones C (Ia) and D (Ib) are isolated as new biflavonoids with flavan‐flavanone skeleton from the EtOH extract of the whole plant.
ChemInform Abstract: Comparison of Solvation Ability and Viscosity Effects of Solvents on the Diels—Alder Reaction
Authors: Makitra R. G. , Karpyak N. M. , Midyana G. G. , Pal'chikova E. Ya. , Marshalok G. A. 
Published: February 2011

AbstractReview: 19 refs.
The Medicinal Potential of Promising Marine Macrolides with Anticancer Activity
Authors: Qi Yunkun , Ma Shutao 
Published: February 2011

AbstractMarine natural products have become a major source of new chemical entities in the discovery of potential anticancer agents that potently suppress various molecular targets. In particular, the marine macrolides, which include an array of novel biomolecules endowed with outstanding cytotoxic and/or antiproliferative activities, are a prominent class of marine natural products that offer continued promise for breakthroughs in anticancer research. Herein we highlight some recent studies of promising marine macrolides, paying particular attention to their discovery, anticancer activities, mechanisms of action, chemical synthesis, and representative analogues.
Carbon Nanotubes as Nanotexturing Agents for High Power Supercapacitors Based on Seaweed Carbons
Authors: Raymundo‐Piñero Encarnación , Cadek Martin , Wachtler Mario , Béguin François 
Published: February 2011

AbstractThe advantages provided by multiwalled carbon nanotubes (CNTs) as backbones for composite supercapacitor electrodes are discussed. This paper particularly highlights the electrochemical properties of carbon composites obtained by pyrolysis of seaweed/CNTs blends. Due to the nanotexturing effect of CNTs, supercapacitors fabricated with electrodes from these composites exhibit enhanced electrochemical performances compared with CNT‐free carbons. The cell resistance is dramatically reduced by the excellent conductivity of CNTs and by the good propagation of ions favored by the presence of opened mesopores. As a consequence, the specific power of supercapacitors based on these nanocomposites is very high. Another advantage related to the presence of CNTs is a better life cycle of the systems. The composite electrodes are resilient during the charge/discharge of capacitors; these are able to perfectly accommodate the dimensional changes appearing in the active material without mechanical damages.
Direct method for quantification of glycidol fatty acid esters in edible oils
Authors: Shiro Hiroki , Kondo Naoki , Kibune Nobuyuki , Masukawa Yoshinori 
Published: February 2011

AbstractIn response to great concerns about glycidol fatty acid esters (GEs), trace contaminants in edible oils which possibly form during refining processes, we previously developed direct methods to quantify GEs using a combination of double SPE and HPLC‐MS. In this study, those quantitative methods were improved to be more rapid without the use of harmful chloroform. To improve the speed, the HPLC‐MS measuring time was reduced from 15 to 5 min by using a step gradient HPLC system, and the evaporation time after the first SPE was shortened from 4 to 1.5 h by changing the solvent used from acetonitrile to methanol. To replace chloroform with other solvents, we adopted tert‐butyl methyl ether/ethyl acetate to dissolve the oils and n‐hexane/ethyl acetate to separate them during the second SPE. The limit of quantification for GE‐in‐oil was 0.082–0.11 µg/g, which is the most sensitive of all existing methods. The recovery values of spiked GEs at concentrations of 1 or 10 µg/g were close to 100%. The levels quantified using an internal standard C17:0‐GE were comparable with those using external standards in four different edible oils tested. This rapid method not using chloroform can be useful as a routine method to quantify GEs in oils.
High‐throughput dielectrophoretic manipulation of bioparticles within fluids through biocompatible three‐dimensional microelectrode array
Authors: Ma Wei , Shi Tielin , Tang Zirong , Liu Shiyuan , Malik Rizwan , Zhang Lei 
Published: February 2011

AbstractDielectrophoresis (DEP) has been deemed as a potential and ideal solution for bioparticle manipulation. A 3‐D carbon micro‐electro‐mechanical system (MEMS) fabricated from the latest developed carbon‐MEMS approach has advantages of offering low‐cost, biocompatible and high‐throughput DEP manipulation for bioparticles. In this paper, a typical process for fabrication of various 3‐D microelectrode configurations was demonstrated; accurate numerical analysis was presented on electric field gradient distribution and DEP force based on various microelectrode array configurations. The effects of electrode edge angle, electrode edge‐to‐edge spacing and electrode height on the electric field distributions were investigated, and optimal design considerations and rules were concluded through analysis of results. The outcomes demonstrate that the sharp edge electrode is more effective in DEP manipulation and both electrode edge‐to‐edge spacing and electrode height are critical design parameters for seeking optimal DEP manipulation. The gradient magnitude increases exponentially as the electrode spacing is reduced and the electric field extends significantly as the electrode height increases, both of which contribute to a higher throughput for DEP manipulation. These findings are consistent with experimental observations in the literature and will provide critical guidelines for optimal design of DEP devices with 3‐D carbon‐MEMS.
One‐year cholesterol lowering treatment reduces medial temporal lobe atrophy and memory decline in stroke‐free elderly with atrial fibrillation: evidence from a parallel group randomized trial
Authors: Tendolkar Indira , Enajat Morteza , Zwiers Marcel P. , van Wingen Guido , de Leeuw Frank‐Erik , van Kuilenburg Janet , Bouwels Leon , Pop Gheorghe , Pop‐Purceleanu Monika 
Published: February 2011

AbstractObjectivesIn elderly patients with atrial fibrillation (AF), medial temporal lobe (MTL) atrophy and white matter lesions (WML) may account for the cognitive decline. Though a combination therapy of statins with cholesterol lowering agents like ezetimibe may be beneficial in patients with AF, its effects on MTL structure and WML remains unknown.MethodsA parallel group double‐blinded randomized trial was performed during 1 year whereby elderly stroke‐free AF patients either received placebo or atorvastatin and ezetimibe on top oral anticoagulation therapy. Neuropsychological performance and inflammatory markers in the blood were assessed at baseline and 1 year later together with amygdala and hippocampal volume as well as WML.ResultsSixty‐three patients were assessed for eligibility, but 29 patients had to be excluded so that 34 patients were randomized to both groups. In the treatment group, the systemic level of inflammation was significantly decreased after 1 year and an improvement in cognitive speed as well as short‐ and long‐term memory was observed. While there was no significant difference in MTL volume at baseline, the placebo group exhibited more atrophy for right amygdala and left hippocampus at follow‐up. Finally, descriptive data showed a slight decline of WML volume in the treatment group.ConclusionsIn spite of limitations due to small sample size, our data suggest that intensive cholesterol lowering therapy in AF patients may slow cognitive decline and atrophy of the MTL. Though these results have to be replicated in a larger sample, they offer potential for future interventions. Copyright © 2011 John Wiley & Sons, Ltd.
Reduced allergy and immunoglobulin E among adults with intracranial meningioma compared to controls
Authors: Wiemels Joseph L. , Wrensch Margaret , Sison Jennette D. , Zhou Mi , Bondy Melissa , Calvocoressi Lisa , Black Peter M. , Yu Herbert , Schildkraut Joellen M. , Claus Elizabeth B. 
Published: February 2011

AbstractMeningioma, the most frequent tumor in the central nervous system, has few recognized risk factors. We explored the role of allergies in a population‐based case–control consortium study of meningioma in five geographic areas. We also studied serum levels of a marker of atopic allergy (IgE) in a subset of study participants, a first for a study on meningioma. Participants (N = 1,065) with surgically resected, pathologically confirmed meningioma and controls (N = 634) selected via random‐digit dialing were recruited and interviewed. Cases were less likely than controls to report history of physician‐diagnosed allergy [odds ratio (OR) = 0.64; 95% confidence interval (95% CI): 0.51–0.80]. Also, cases (N = 295) had lower total serum IgE than controls [N = 192; OR = 0.85, 95% CI: 0.75–0.98 for each unit of Ln(IgE)]. Similar to glioma and cancers at several other sites, meningioma appears to have an inverse relationship with history of allergies and a biomarker of atopic allergy. As some common opposing predisposition or developmental processes for allergy and meningioma may exist, further research into immune processes that can affect the incidence and natural history of meningioma is warranted.
Design and synthesis of Raman reporter molecules for tissue imaging by immuno‐SERS microscopy
Authors: Schütz Max , Müller Christian I. , Salehi Mohammad , Lambert Christoph , Schlücker Sebastian 
Published: February 2011

AbstractThe design and synthesis of Raman reporter molecules comprising olefin or alkyne moieties with strong and characteristic vibrational Raman bands is presented. Chemisorption onto the surface of colloidal Au/Ag shells yields a self‐assembled monolayer. Hydrophilic stabilization of such SERS labels can be achieved by short terminal ethylene glycol units attached to the Raman reporter. Encapsulation by silica with subsequent functionalization of the glass surface allows the conjugation to biomolecules such as antibodies. We demonstrate the use of SERS‐labeled antibodies for tissue imaging of the tumor suppressor p63 in prostate biopsies. (© 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)