bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fuel‐Driven and Enzyme‐Regulated Redox‐Responsive Supramolecular Hydrogels
Authors: Jain Mehak , Ravoo Bart Jan 
Published: July 2021

AbstractChemical reaction networks (CRN) embedded in hydrogels can transform responsive materials into complex self‐regulating materials that generate feedback to counter the effect of external stimuli. This study presents hydrogels containing the β‐cyclodextrin (CD) and ferrocene (Fc) host–guest pair as supramolecular crosslinks where redox‐responsive behavior is driven by the enzyme–fuel couples horse radish peroxidase (HRP)–H2O2 and glucose oxidase (GOx)–d‐glucose. The hydrogel can be tuned from a responsive to a self‐regulating supramolecular system by varying the concentration of added reduction fuel d‐glucose. The onset of self‐regulating behavior is due to formation of oxidation fuel in the hydrogel by a cofactor intermediate GOx[FADH2]. UV/Vis spectroscopy, rheology, and kinetic modeling were employed to understand the emergence of out‐of‐equilibrium behavior and reveal the programmable negative feedback response of the hydrogel, including the adaptation of its elastic modulus and its potential as a glucose sensor.
Sustainable design and novel synthesis of highly recyclable magnetic carbon containing aromatic sulfonic acid: Fe3O4@C/Ph—SO3H as green solid acid promoted regioselective synthesis of tetrazoloquinazolines
Authors: Hassankhani Asadollah , Gholipour Behnam , Rostamnia Sadegh , Zarenezhad Elham , Nouruzi Nasrin , Kavetskyy Taras , Khalilov Rovshan , Shokouhimehr Mohammadreza 
Published: July 2021

AbstractA green and stable magnetic Fe3O4 core encapsulated in porous carbon shell was prepared. Then, the surface of as‐synthesized Fe3O4@meso‐C immobilized with activated 4‐aminobenzenesulfonic acid to achieve Fe3O4@C/Ph—SO3H. Structural, physico‐chemical, and magnetic properties of synthesized Fe3O4@C/Ph—SO3H catalyst using various analyses such as FT‐IR spectroscopy, TGA, XRD, SEM, TEM. EDX, and VSM were investigated. Fe3O4@C/Ph—SO3H was used as a stable and recoverable acid catalyst for regioselective three‐component synthesis of tetrazoloquinazolines under mild conditions. This catalyst offers a green protocol of one pot due to having active SO3H groups, reacting in mild conditions with high yield and ability to recover and reuse without significant loss in activity.
In‐depth material characterization of polyhydroxybutyrate from a forest biorefinery
Authors: Dietrich Karolin , Dumont Marie‐Josée , Orsat Valérie , Del Rio Luis F. 
Published: July 2021

AbstractLarge‐scale replacement of petroplastics with compostable plastics, like polyhydroxybutyrates (PHB) will contribute to elimination plastic pollution, decrease greenhouse gas emissions, and valorize local biomass resources. Lignocellulose hydrolysates have emerged as potentially sustainable carbon sources for PHB production. For industrial processing, it is necessary to know the polymer properties. Yet, most studies on PHB samples from lignocellulose report few material properties. PHB samples produced from a pilot scale hardwood holocellulose hydrolysate conversion process were characterized and compared with PHB from a sugar hydrolysate and a commercial PHB powder. PHB from hardwood holocellulose hydrolysate was found to be comparable with commercial PHB in all properties. Differential scanning calorimetry and thermal gravimetric analysis showed that all samples had similar thermal behavior, where the melting temperature was 176°C and the decomposition temperature was 293°C. From the melting enthalpy, all samples showed 63% crystallinity. Dynamic mechanical analysis showed a glass transition temperature at 5°C and a crystallization temperature of 57°C. Fourier transform infrared spectroscopy and nuclear magnetic resonance confirmed that the samples were homopolymers comprised of hydroxybutyrate units. The difference among the samples was the number average molecular mass, being lower for wood hydrolysate (246.4 kDa) than sugar hydrolysate (670.3 kDa).
Efficient cage structured polyhedral oligomeric silsesquioxane embedded poly(vinyl alcohol) membranes: Thermal degradation and mechanical stability in hydrated condition
Authors: Swapna Valiya Parambath , Krishnan Meera , Abhisha Vakkoottil Sivadasan , Stephen Ranimol 
Published: July 2021

AbstractIn this work, the thermal degradation of functionalized cage structured polyhedral oligomeric silsesquioxane (POSS) incorporated poly(vinyl alcohol) (PVA) and poly(vinyl alcohol)‐poly (ethylene oxide) (PEO) blend membranes were discussed. PVA‐PEO/POSS and cross‐linked PVA/POSS systems exhibited excellent improvement in thermal stability at lower loading of POSS as compared to pure PVA and uncross‐linked PVA/POSS system. Uncross‐linked PVA and PVA/POSS systems exhibited mainly two degradation steps. However, cross‐linked PVA/POSS systems showed more degradation steps due to the formation of 3‐dimentional network structure in the polymer. The mechanical stability of PVA/POSS and PVA‐PEO/POSS systems at hydrated state were analyzed and observed a remarkable stability even in the wet condition.
Ersatzmodell zur Untersuchung der Einflüsse der Installation von Stahlträgern auf die Lagegenauigkeit
Authors: Beuße Jannik , Grabe Jürgen 
Published: July 2021

AbstractWährend des Kaimauerbaus ist die plangenaue Installation der Träger herausfordernd und zugleich unabdingbar, um die Zwischenbohlen kombinierter Stahlspundwände einbringen zu können. Die Doppel‐T‐Träger haben profilbedingt, im Vergleich zu einem Rundrohrstahl, eine geringe Biegesteifigkeit um die schwache Achse und eine geringere Torsionssteifigkeit. Damit sind die Träger bei unsachgemäßer Einbringung stark verformungsgefährdet. Bisher wird das komplexe dynamische Zusammenspiel aus dem Einbringgerät, den gewählten Geräteparametern, dem Träger und dem Boden nicht hinreichend betrachtet, um genaue Prognosen zur erforderlichen Rammführung treffen zu können. Dazu wird ein mithilfe von Messdaten validiertes Ersatzmodell aufgebaut, welches die Einbringung eines Trägers abbilden kann. Hiermit gelingt die gezielte Untersuchung einzelner Einflussfaktoren, wie der Neigung des Schlaghammers, der Neigung des Trägers, der Trägerimperfektion sowie unterschiedlicher Rammführungen.
Co‐utilization of amino acid‐rich wastes and glycerol for microbial lipid production
Authors: Kamal Rasool , Huang Qitian , Wang Qian , Yu Xue , Song Jingyi , Limtong Savitree , Zhao Zongbao K. 
Published: July 2021

AbstractMicrobial lipids are considered to be potential raw materials for biodiesel production. However, the costs of such a process remain high due to the use of expensive feedstocks for microbial lipid production. The meat industry and biodiesel refineries generate amino acid (AA) wastes and crude glycerol, respectively, which could be explored as relatively cheap feedstocks for oleaginous yeasts. Unfortunately, AA wastes have a high nitrogen content and crude glycerol contains several impurities, discouraging microbial lipid production. Here, glycerol was co‐used with AA, or with AA blends with compositional profiles matching those of different meats, so that the media had favorable carbon‐to‐nitrogen (C/N) ratios to promote AA conversion into lipids using the oleaginous yeast Cryptococcus curvatus ATCC 20509 under two‐stage culture conditions. Co‐utilization of glycerol and AA resulted in improved lipid production. The highest lipid yield of 20.9 g 100 g–1 was achieved with lysine and glycerol, where the lipid yield was 13.9 g 100 g–1, using an AA blend of similar composition to sheep viscera and glycerol. The lipid products comprised over 93% of 16 and 18 carbon‐containing fatty acids, showing high potential for biodiesel production. The co‐use of glycerol with AA improved AA conversion into lipids while decreasing the inhibitory effects at relatively high AA concentrations. The utilization of crude glycerol and AA‐rich wastes from the meat industry could help both the development of biorefineries and waste minimization. © 2021 Society of Chemical Industry and John Wiley & Sons, Ltd
Comparative analysis of bioactive constituents and pharmacological activities from different parts of Nauclea officinalis
Authors: Zhou Mingyan , Xie Zhenrui , Guan Weiwei , Zhang Junqing 
Published: July 2021

AbstractThe stems of Nauclea officinalis have been utilized as a crude drug in China, so other parts of the plant are abandoned, resulting in a waste of traditional Chinese medicine resources. To determine the distribution and content of the alkaloids, phenolic acids and iridoid in different organs (stem, branch, leaf and bark) of this plant, a reliable method has been established using LC–MS/MS. Nine constituents, namely strictosamide, vincosamide, chlorogenic acid, sweroside, naucleamide B, protocatechuic acid, pumiloside, vanillic acid and cryptochlorogenic acid, were simultaneously determined in 6 min. Meanwhile, the antipyretic, anti‐inflammatory and analgesic activities were evaluated for comparative analysis of the pharmacological activity of different parts of N. officinalis. The results showed that the content of active components in other organs of N. officinalis was higher than that in stems, and the pharmacological effects of branches and leaves were also better. The established approach could be helpful for the quality control of N. officinalis, and also provide necessary information for the rational utilization of resources.
The Multiple Pedicle Coronally Advanced Flap for Multiple Deep Miller Class II Recessions: A Case Report
Authors: Tunkel Jochen , Hofmann Frederik , de Stavola Luca 
Published: July 2021

IntroductionIn recent years, several methods have been described for the treatment of deep Miller Class II recessions. Most of these techniques concentrate on single recessions or one deep recession accompanied by just slight neighboring root denudations. A modified technique is presented for treating two or more deep recessions beyond the mucogingival margin combining a subepithelial connective tissue graft (SCTG), enamel matrix derivative, and a multiple pedicle coronally advanced flap. To the best of our knowledge, this is the first report to describe the treatment of multiple deep Miller Class II recessions exceeding beyond the mucogingival junction using a pedicled advanced flap.Case PresentationA 29‐year‐old woman was referred to the periodontal practice of JT for the treatment of progressive deep Miller Class II recessions. The root coverage procedure was performed by a modified multiple pedicle flap combined with a connective tissue graft harvested from the palate and enamel matrix derivative. The case was followed up for 2 years.ConclusionsThis modified technique of a multiple pedicled flap is a feasible and useful method for treating several deep neighboring recessions. Due to the improved incision techniques, scar tissue formation might be reduced not to interfere with the esthetic result.
Impact of wheat gluten on the denaturation of egg white and whey proteins
Authors: Van de Vondel Julie , Lambrecht Marlies A. , Delcour Jan A. 
Published: July 2021

AbstractBackground and objectivesWheat gluten (WG) often co‐exists with egg white (EW) and whey proteins in foods. This study investigated the impact of WG on the denaturation of hen egg (S‐)ovalbumin [(S‐)OVA], lysozyme (LYS), and bovine serum albumin (BSA).FindingsWG caused the peak temperature of denaturation of LYS and BSA to increase and that of (S‐)OVA to decrease. It accelerated and decelerated denaturation of BSA and OVA, respectively, and their lowered activation energy. In contrast, the denaturation rate of S‐OVA was higher and the activation energy was not affected by the presence of WG. LYS denaturation was reversible, both in the presence and in the absence of WG. Heating induced changes in the surface hydrophobicity of OVA and BSA and changes in the ζ‐potential of LYS, while the levels of their free sulfhydryl groups did not change.ConclusionsIn model systems, WG impacts both temperatures and kinetics of denaturation of the studied proteins. Hydrophobic interactions between WG and OVA or BSA impact their denaturation kinetics.Significance and noveltyThis study is the first to demonstrate the impact of WG on the denaturation of EW and whey proteins. These insights will be useful in food product design and further elucidating co‐protein effects.
Synergistic Coupling of NiTe Nanoarrays with FeOOH Nanosheets for Highly Efficient Oxygen Evolution Reaction
Authors: Li Yadong , Chen Baojin , Zhang Huaming , Gao Jing , Sun Huachuan , Habibi‐Yangjeh Aziz , Wang Chundong 
Published: July 2021

AbstractHydrogen is the most promising alternative energy source in the face of energy crisis, and water splitting is a green strategy for hydrogen generation. The oxygen evolution reaction (OER) is the essential half‐reaction in electrochemical water splitting, and thus development and exploration of electrocatalysts with excellent performance are vital to prompt the application of OER. Due to the unique electronic properties of NiTe and strong synergistic interaction between NiTe and FeOOH, NiTe@FeOOH hybrid nanorods were successfully fabricated on Ni foams (NF) by a hydrothermal reaction step and another in‐situ growth step for the first time without consuming any extra energy. The 3D structure of the NiTe@FeOOH/NF was confirmed by powder X‐ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X‐ray photoelectron spectroscopy (XPS) and energy dispersive spectrometry (EDS) mapping technologies. Electrochemical measurements showed that the as‐prepared NiTe@FeOOH/NF needs only an overpotential of 241 mV to achieve a current density of 10 mA cm−2 in 1.0 M KOH and requires 1.341 V to drive 10 mA cm−2 in 1 M KOH with a 0.33 M urea, showing excellent long‐term stability. The NiTe@FeOOH/NF as the bifunctional electrocatalyst in an electrolyzer shows high efficiency with a cell voltage of 1.50 V at 10 mA cm−2. This work can provide a new efficient method to construct highly active and cost‐effective OER catalysts.
Quantitative Distinction between Noble Metals Located in Mesopores from Those on the External Surface
Authors: Rieg Carolin , Dittmann Daniel , Li Zheng , Lawitzki Robert , Gugeler Katrin , Maier Sarah , Schmitz Guido , Kästner Johannes , Estes Deven P. , Dyballa Michael 
Published: July 2021

AbstractWe compare three methods for quantitatively distinguishing the location of noble metal (NM) particles in mesopores from those found on the external support surface. MCM‐41 and SBA‐15 with NM located in mesopores or on the external surface were prepared and characterized by TEM. 31P MAS NMR spectroscopy was used to quantify arylphosphines in complexes with NM. Phosphine/NM ratios drop from 2.0 to 0.2 when increasing the probe diameter from 1.08 to 1.54 nm. The reaction between NM and triphenylphosphine (TPP) within 3.0 nm MCM‐41 pores takes due to confinement effects multiple weeks. In contrast, external NM react with TPP instantly. A promising method is filling the pores by using the pore volume impregnation technique with tetraethylorthosilicate (TEOS). TPP loading revealed that 66 % of NMs are located on the external surface of MCM‐41. The pore filling method can be used in association with any probe molecule, also for the quantification of acid sites.
Reversible Self‐Assembly of Gold Nanoparticles Based on Co‐Functionalization with Zwitterionic and Cationic Binding Motifs**
Authors: He Huibin , Rudolph Kevin , Ostwaldt Jan‐Erik , Voskuhl Jens , Hirschhäuser Christoph , Niemeyer Jochen 
Published: July 2021

AbstractWe report a pH‐ and temperature‐controlled reversible self‐assembly of Au‐nanoparticles (AuNPs) in water, based on their surface modification with cationic guanidiniocarbonyl pyrrole (GCP) and zwitterionic guanidiniocarbonyl pyrrole carboxylate (GCPZ) binding motifs. When both binding motifs are installed in a carefully balanced ratio, the resulting functionalized AuNPs self‐assemble at pH 1, pH 7 and pH 13, whereas they disassemble at pH 3 and pH 11. Further disassembly can be achieved at elevated temperatures at pH 1 and pH 13. Thus, we were able to prepare functionalized nanoparticles that can be assembled/disassembled in seven alternating regimes, simply controlled by pH and temperature.
Possible activation of effector B cells during drug‐induced hypersensitivity syndrome
Authors: Matsumura Yutaka , Watanabe Rei , Niijima Yasuko , Kawakita Haruka , Furuta Junichi , Nakamura Yoshiyuki , Ishitsuka Yosuke , Okiyama Naoko , Fujisawa Yasuhiro , Fujimoto Manabu 
Published: July 2021

AbstractAlthough the development of autoimmune disorders is recognized in drug‐induced hypersensitivity syndrome (DIHS), the serial change of B‐cell activity has not been well‐addressed. Herein, the serum levels of IL‐6, IL‐10, B‐cell activating factor of the tumor necrosis factor family (BAFF), and a proliferation‐inducing ligand (APRIL) in three DIHS patients were tracked over time. While IL‐6 and IL‐10 tended to be elevated according to the disease activity, BAFF and APRIL increased during the improved phase. Our results imply that the continuous activation of B cells may be involved in the prolonged disease activity of DIHS and the development of autoimmune disorders.
Evaluation and associated risk factors for neutropenia with venetoclax and obinutuzumab in the treatment of chronic lymphocytic leukemia
Authors: Samuels Courtney , Abbott Diana , Niemiec Sierra , Tobin Jennifer , Falco Angela , Halsema Keri , Kamdar Manali 
Published: July 2021

AbstractBackgroundThe time‐limited combination of venetoclax and obinutuzumab (VenG) was established by the German CLL Study Group in the CLL14 trial for the upfront management of newly diagnosed chronic lymphocytic leukemia (CLL), showing a superior progression free survival benefit. The incidence of grade 3–4 neutropenia was reported in the range of 52.8%–57.7%. However, patients who develop neutropenia with this combination have yet to be formally characterized in the literature as it has impact on the clinical practice setting.AimTo determine the incidence of grade 3 and 4 neutropenia and identify risk factors for neutropenia among CLL patients treated with the VenG regimen.MethodsWe conducted a retrospective, single‐center study of all adult patients with a diagnosis of CLL treated with VenG at the University of Colorado Hospital. Demographic information, laboratory data, clinical data, and medication prescriptions were collected from the patients' electronic medical record.ResultsA total of 14 patients (73%) developed neutropenia during the course of therapy. The mean time to neutropenia from the start of treatment was 42 days (range 1–131). Our cohort harbored more high risk disease features and more comorbidities (CIRS score of 12). Four patients (28.6%) in the neutropenic group developed infectious complications during therapy and 6 (31%) patients were unable to be dose escalated to the final FDA approved dose of 400 mg.ConclusionOur study cohort had higher incidence of grade 3 and 4 neutropenia occurring in 73% of patients. This could be attributed to a higher rate of comorbidities, high risk features, concomitant interacting medications, and prior chemotherapy. Further studies are warranted to determine if growth factor support is efficacious to achieve dose escalation with this therapy.
Establishment of a color tolerance for yarn‐dyed fabrics from different color‐depth yarns
Authors: Wang Xiaoyan , Jiang Yang , Du Jinmei , Xu Changhai 
Published: July 2021

AbstractYarn‐dyed fabric is often woven from warp and weft yarns in the same color depth to ensure a uniform color appearance. The difference in color depth between warp and weft tends to result in the uneven color of the yarn‐dyed fabric. This article aims to establish a color tolerance for yarn‐dyed fabric that can be woven with a qualified color appearance but from the warp and weft yarns in different color depths. A total of 27 yarn‐dyed fabric samples in three color series (red, yellow, and blue) were evaluated by using the yarn‐dyed fabric from warp and weft yarns in the same color depth of 2% (on weight of fabric, owf) as the standard. Visual assessment and instrumental measurement of color were carried out to establish the color tolerance ellipse that was defined as CMC (Color Measurement Committee) color differences (2:1) of no more than 1.00. It was found that the color strengths (K/S) and color differences (ΔECMC(2:1)) of these fabric samples for each color series had linear relationships with the color depths of warp and weft yarns. The color tolerance ellipses indicated that, even though the warp and weft yarns had an apparent color difference, they could be woven in fabrics with relatively uniform color appearance and meet the requirements for yarn‐dyed fabric. This work provided valuable insight into the production of qualified yarn‐dyed fabrics from unqualified dyed yarns.
Capitalizing the database cost models process through a service‐based pipeline
Authors: Ouared Abdelkader , Ouhammou Yassine 
Published: July 2021

AbstractDesigning a database cost model is one of the main research topics related to the physical design phase. It follows the evolution of database technology in order to evaluate and quantify the performance metrics (e.g., response time, energy consumption, etc.). Therefore, it makes the community researchers sensitive to the generated results. However, reusing and comparing database cost models require extracting related information manually from the research publications. This process is error‐prone and time‐consuming. Unfortunately, many researchers claim the difficulty of surveying and reproducing cost models already published in several/journal articles and/or reports. This difficulty is due to the absence of a process describing the cost model itself formally as well as the context of its utilization. This article presents an approach enabling the extraction of cost models information (context, parameters, features, etc.) as a set of orchestrated services. These services are implemented using natural language processing and machine‐learning techniques via a work‐flow pipeline inspired by DevOps practices. We illustrate our approach on a case study to stress the feasibility and benefits of our proposal by emphasizing the reproduction and automatization facilities.
sRSP: An efficient and scalable implementation of remote scope promotion
Authors: Yilmazer‐Metin Ayse 
Published: July 2021

AbstractGPUs only support simple coherence operations. For data integrity, heavyweight synchronization operations must be explicitly used. Scoped synchronization Hower et al. (2014) and Gaster et al. (2015) has been introduced to facilitate low overhead communication, when the communication is local across a subset of threads. Scoped synchronization can be used if the sharing is static. However, it is not possible to avoid using heavyweight global‐scoped synchronization when the sharing is dynamic. Asymmetric sharing is one of the dynamic sharing patterns where a shared data is frequently accessed by a single agent while being rarely accessed by remote agents. It requires using global‐scoped synchronization to encompass all possible synchronization agents on a GPU device without any special support. Remote scope promotion (RSP) Orr et al. (2015) allows use of lightweight local‐scoped synchronization for frequent accesses and defers the most synchronization overhead to the rare remote accesses. We propose sRSP which is an efficient and scalable implementation of RSP semantics. sRSP tracks local‐scoped synchronizations on local caches. When performing remote‐scoped synchronization, it applies the costly cache operations selectively. We thoroughly evaluate our work and show that it reduces remote synchronization overhead significantly and scales better. On the average, it improves the performance around 25% for a GPU device with 64 compute units.