bluuebunny/crossref_metadata_2025_split huggingface dataset:
Complement factor B regulates cellular senescence and is associated with poor prognosis in pancreatic cancer
Authors: Shimazaki Reiri , Takano Shigetsugu , Satoh Mamoru , Takada Mamoru , Miyahara Yoji , Sasaki Kosuke , Yoshitomi Hideyuki , Kagawa Shingo , Furukawa Katsunori , Takayashiki Tsukasa , Kuboki Satoshi , Sogawa Kazuyuki , Motohashi Shinichiro , Nomura Fumio , Miyazaki Masaru , Ohtsuka Masayuki 
Published: June 2021

Abstract
Background
The interplay between cancer cells and stromal components, including soluble mediators released from cancer cells, contributes to the progression of pancreatic ductal adenocarcinoma (PDAC). Here, we set out to identify key secreted proteins involved in PDAC progression.

Methods
We performed secretome analyses of culture media of mouse pancreatic intraepithelial neoplasia (PanIN) and PDAC cells using Stable Isotope Labeling by Amino acid in Cell culture (SILAC) with click chemistry and liquid chromatography-mass spectrometry (LC-MS/MS). The results obtained were verified in primary PDAC tissue samples and cell line models.

Results
Complement factor B (CFB) was identified as one of the robustly upregulated proteins, and found to exhibit elevated expression in PDAC cells compared to PanIN cells. Endogenous CFB knockdown by a specific siRNA dramatically decreased the proliferation of PDAC cells, PANC-1 and MIA PaCa-II. CFB knockdown induced increases in the number of senescence-associated-β-galactosidase (SA-β-gal) positive cells exhibiting p21 expression upregulation, which promotes cellular senescence with cyclinD1 accumulation. Furthermore, CFB knockdown facilitated downregulation of proliferating cell nuclear antigen and led to cell cycle arrest in the G1 phase in PDAC cells. Using immunohistochemistry, we found that high stromal CFB expression was associated with unfavorable clinical outcomes with hematogenous dissemination after surgery in human PDAC patients. Despite the presence of enriched CD8+ tumor infiltrating lymphocytes in the PDAC tumor microenvironments, patients with a high stromal CFB expression exhibited a significantly poorer prognosis compared to those with a low stromal CFB expression. Immunofluorescence staining revealed a correlation between stromal CFB expression in the tumor microenvironment and an enrichment of immunosuppressive regulatory T-cells (Tregs), myeloid-derived suppressor cells (MDSCs) and tumor-associated macrophages (TAMs). We also found that high stromal CFB expression showed a positive correlation with high CD8+/Foxp3+ Tregs populations in PDAC tissues.

Conclusions
Our data indicate that CFB, a key secreted protein, promotes proliferation by preventing cellular senescence and is associated with immunological tumor promotion in PDAC. These findings suggest that CFB may be a potential target for the treatment of PDAC.
Sesquiterpenoids and 2-(2-Phenylethyl)chromone Derivatives from the Resinous Heartwood of Aquilaria sinensis
Authors: Wei Shu-Ya , Hu Dong-Bao , Xia Meng-Yuan , Luo Ji-Feng , Yan Hui , Yang Jing-Hua , Wang Yun-Song , Wang Yue-Hu 
Published: June 2021

AbstractOne novel spirolactone, aquilarisinolide (1), three new sesquiterpenoids, (2R,4S,5R,7R)-2-hydroxyeremophila-9,11-dien-8-one (2), (1R,4S,5S,7R,11R)-13-hydroxyepidaphnauran-9-en-8-one (3), and (4R,5S,7R,8S,10S,13R)-8,13-dihydroxyrotunda-1,11-dien-3-one (4), together with 13 known compounds (5–17) were isolated from the resinous heartwood of Aquilaria sinensis (Thymelaeaceae). The structures of the new compounds were elucidated based on the analysis of NMR and MS data and theoretical calculations their ECD spectra. The isolated compounds were evaluated for their protective activities against PC12 cell injury induced by corticosterone (CORT) and 1-methyl-4-phenylpyridine ion (MPP+), as well as inhibitory activities against BACE1. Compound 4, 5,6-dihydroxy-2-(2-phenylethyl)chromone (5), daphnauranol B (7), 6-methoxy-2-[2-(3-methyoxyphenyl)ethyl]chromone (10), isoagarotetrol (14), and 1-hydroxy-1,5-diphenylpentan-3-one (16) showed significant protective effects on CORT-induced injury in PC12 cells at a concentration of 20 μM (P < 0.001). Isoagarotetrol (14) showed a significant protective effect on MPP+-induced injury in PC12 cells at a concentration of 20 μM (P < 0.001), while compound 4 showed a moderate activity (P < 0.01). The BACE1-inhibitory activities of all tested compounds were very weak with less than 30% inhibition at a concentration of 20 μM.
Graphic Abstract
What is in the KGQA Benchmark Datasets? Survey on Challenges in Datasets for Question Answering on Knowledge Graphs
Authors: Steinmetz Nadine , Sattler Kai-Uwe 
Published: June 2021

AbstractQuestion Answering based on Knowledge Graphs (KGQA) still faces difficult challenges when transforming natural language (NL) to SPARQL queries. Simple questions only referring to one triple are answerable by most QA systems, but more complex questions requiring complex queries containing subqueries or several functions are still a tough challenge within this field of research. Evaluation results of QA systems therefore also might depend on the benchmark dataset the system has been tested on. For the purpose to give an overview and reveal specific characteristics, we examined currently available KGQA datasets regarding several challenging aspects. This paper presents a detailed look into the datasets and compares them in terms of challenges a KGQA system is facing.
An easy and practical guide for imaging infection/inflammation by [18F]FDG PET/CT
Authors: Signore Alberto , Casali Massimiliano , Lauri Chiara 
Published: June 2021

Abstract
Aim
The aim of this mini-review was to summarize the role of positron emission tomography/computed tomography (PET/CT) with 18Fluorine-fluorodeoxyglucose ([18F]FDG) in inflammatory and infective processes, based on the published scientific evidence.

Methods
We analysed clinical indications, patient preparation, image acquisition protocols, image interpretation, pitfalls and how to make the report of cardio-vascular diseases, musculoskeletal diseases and other inflammatory and infective systemic diseases.
Results of this analysis are shown in practical tables, easy to understand for daily routine consultation.

Conclusions
Despite [18F]FDG is currently used in several inflammatory and infective diseases, standardized interpretation criteria are still needed in most cases. It is, therefore, foreseen the execution of multicentre clinical studies that, by adopting the same acquisition and interpretation criteria, may contribute to the standardization of this imaging modality.
Third reported case of rare necrolytic migratory erythema associated with bacteraemia due to severe zinc deficiency after revisional Roux-En-Y gastric bypass: case report and literature review
Authors: Salaheldin Yassmin , El Ansari Walid , Aljaloudi Esraa , Elhag Wahiba 
Published: June 2021

Abstract
Introduction
Obesity is a risk factor for zinc deficiency. After bariatric surgery, non-compliance to diet/vitamin supplements, surgical complications leading to vomiting/diarrhea, poor follow-up and malabsorption can precipitate or exacerbate pre-existing zinc deficiency.

Case report
We report a patient with rare necrolytic migratory erythema associated with bacteraemia due to severe zinc deficiency after revisional Roux-en-Y gastric bypass (following primary laparoscopic sleeve gastrectomy).

Conclusion
Bariatric teams should screen patients before bariatric surgery for nutritional deficiencies and continue surveillance of their nutritional status after surgery. They should maintain a high index of suspicion for zinc deficiency in patients with skin rash after bariatric surgery.

Level of evidence
Level V, case report.
Online social networks security and privacy: comprehensive review and analysis
Authors: Jain Ankit Kumar , Sahoo Somya Ranjan , Kaubiyal Jyoti 
Published: June 2021

AbstractWith fast-growing technology, online social networks (OSNs) have exploded in popularity over the past few years. The pivotal reason behind this phenomenon happens to be the ability of OSNs to provide a platform for users to connect with their family, friends, and colleagues. The information shared in social network and media spreads very fast, almost instantaneously which makes it attractive for attackers to gain information. Secrecy and surety of OSNs need to be inquired from various positions. There are numerous security and privacy issues related to the user’s shared information especially when a user uploads personal content such as photos, videos, and audios. The attacker can maliciously use shared information for illegitimate purposes. The risks are even higher if children are targeted. To address these issues, this paper presents a thorough review of different security and privacy threats and existing solutions that can provide security to social network users. We have also discussed OSN attacks on various OSN web applications by citing some statistics reports. In addition to this, we have discussed numerous defensive approaches to OSN security. Finally, this survey discusses open issues, challenges, and relevant security guidelines to achieve trustworthiness in online social networks.
Chained graphs and some applications
Authors: Concas Anna , Reichel Lothar , Rodriguez Giuseppe , Zhang Yunzi 
Published: June 2021

AbstractThis paper introduces the notions of chained and semi-chained graphs. The chain of a graph, when existent, refines the notion of bipartivity and conveys important structural information. Also the notion of a center vertex $$v_c$$

v
c

is introduced. It is a vertex, whose sum of p powers of distances to all other vertices in the graph is minimal, where the distance between a pair of vertices $$\{v_c,v\}$$

{

v
c

,
v
}

is measured by the minimal number of edges that have to be traversed to go from $$v_c$$

v
c

to v. This concept extends the definition of closeness centrality. Applications in which the center node is important include information transmission and city planning. Algorithms for the identification of approximate central nodes are provided and computed examples are presented.
Discourses in Subjective Experience on Rehabilitation
Authors: Ylimaula Sirpa , Suorsa Teemu 
Published: June 2021

AbstractIn Finland, youth workshops support participants’ everyday management, social empowerment and employability skills, facilitating their access to education and work. In this study, we analysed conversations with ten participants about their experiences in non-formal learning workshops in Northern Finland. We explore how participants described personal transformation borne by workshop participation and how the prevalent discourses on youth (un)employment manifest in participants’ reasons for action. In the analysis, we identified (1) how participants assessed their situations; (2) their thoughts, feelings and actions in relation to their situations; and (3) their grounds for these thoughts, feelings and actions. The societal dimension of subjective experience is articulated by identifying the prevalent societal discourses featured in participants’ descriptions. The analysis showed that participants described themselves as vulnerable prior to the intervention and motivated after the intervention. Participants experienced tailored support as being significant in fostering the change. Individual descriptions of how the learning and training conditions were experienced constitute valuable knowledge about the possible ways of acting and experiencing in relation to common structures. With the help of these descriptions, it would be valuable for researchers and participants to continue the conversation about the discourses to enhance the participants’ conscious participation in maintaining and changing their living conditions.
The ‘3CE2CE’ Framework—Change Management Towards a Circular Economy: Opportunities for Agribusiness
Authors: Yang Nan-Hua Nadja , Bertassini Ana Carolina , Mendes Jéssica Alves Justo , Gerolamo Mateus Cecílio 
Published: June 2021

AbstractFor the transition towards a circular economy (CE), organisations have to be prepared to adapt to major changes. Thus, the concept and implementation of change management (CM) will be essential to an organisation’s success during this transformative period. Studies have shown that organisational CE barriers were more significant than individual CE barriers. To overcome such obstacles, the most appropriate set of managerial practices should be carefully considered. These barriers also have the potential to influence the agricultural sector, which seeks to adopt more sustainable ways of production. The goal of this paper is to propose a solution framework based on CM strategies to overcome organisational challenges posed by a CE, especially for agribusinesses. To accomplish this objectively, a systematic literature review and a content analysis were conducted. The common errors in CM within the implementation process and the main CE barriers were identified and classified. An in-depth analysis of the issue’s roots led to a solid understanding of how to tackle such CM problems. This paper presents an overview of organisational CE barriers verified in the agricultural context, the common errors in CM, and the correlation between these findings. The two areas were then combined in a matrix that shows the connection between common errors in CM errors and CE barriers. Based on this result, a solution framework called 3CE2CE was developed that provides a step-by-step guide on how organisations can successfully undergo transformation processes towards a CE with the principles of CM.
Acceptability of Health Professionals’ Address of Sexuality and Erectile Dysfunction - A Qualitative Interview Study with Men in Cardiac Rehabilitation
Authors: Gerbild Helle , Areskoug-Josefsson Kristina , Larsen Camilla Marie , Laursen Birgitte Schantz 
Published: June 2021

AbstractIntroductionIn the developing phase of the complex health intervention: Physical Activity to reduce Vascular Erectile Dysfunction (PAVED), it is crucial to explore whether men can accept the communicative component regarding information that regular aerobe Physical Activity can reduce Erectile Dysfunction (i-PAVED). This information is provided by health professionals (HPs) in cardiac rehabilitation, where sexuality issues such as erectile dysfunction (ED) are otherwise rarely addressed.AimTo explore how acceptance of cardiac HPs’ address of sexuality, ED, and i-PAVED can be identified in men's narratives.MethodsIn this descriptive qualitative study, we conducted semi-structured individual interviews with 20 men (range 48-78 years of age) attending municipal cardiac secondary prevention and rehabilitation programmes on their acceptance of HPs’ address of sexuality, ED, and i-PAVED. The Theoretical Framework of Acceptability components (affective attitude, burden, ethicality, intervention coherence, perceived effectiveness, opportunity costs and self-efficacy) and three temporal perspectives (retrospective, concurrent and prospective) were used in the concept-driven first step of a content analysis, which was followed by a thematically data-driven second step.Main Outcome MeasuresMen anticipated and experiential acceptance was identified in six out of seven components of Theoretical Framework of Acceptability.ResultsMen acceptance was identified as “expression of interest,” “addressing sexuality,” “attitudes and values,” “understandable and meaningful,” “insights” and “motivation,” whereas no narratives were identified in relation to the component of opportunity costs.ConclusionAs an aspect of the development of the complex cardiovascular health care intervention PAVED, this qualitative study showed that men attending cardiac secondary prevention and rehabilitation seemed to prospectively accept the communicative component of PAVED being HPs’ address of sexuality, ED, and i-PAVED, if the HPs are professional, educated and competent in the field of sexual health.
Logic, geometry and visualisation of the body in Acquapendente’s rediscovered Methodus anatomica (1579)
Authors: Bigotti Fabrizio 
Published: June 2021

AbstractThe article provides the first description and analysis of the recently rediscovered manuscript titledMethodus anatomicaby Girolamo Fabrici da Acquapendente (1533–1619). Acquapendente was one of the most important anatomists in late sixteenth-century Europe and played an instrumental role as Harvey’s teacher in Padua towards the latter’s discovery of the circulation of the blood. The manuscript provides first-hand testimony as to how anatomy was administered in Padua in the post-Vesalian era and sheds light on a number of otherwise unknown aspects of the development of the anatomical method. Chiefly among these is the attention devoted by Acquapendente tohistoria, as a way to order sensory data in a consistent way, which draws widely from the geometrical method and from the contemporary debate on the discretisation of continuous quantities.
Warfare and the launch of medical reform in Britain, 1793–1811
Authors: Mackintosh Alan 
Published: June 2021

AbstractUntil the beginning of the nineteenth century, registering and regulating the training of any medical practitioners in Britain had rarely been attempted, unlike in many other European countries. During the Revolutionary War with France, fevers swept through British armies, leading to numerous fatalities and crushing military defeats, especially in the disastrous expedition to St Domingo. The problem, as forcibly advocated by Robert Jackson, the leading expert on military fevers, seemed to be poor medical care due to both lack of compulsory medical training and the unsuitability of whatever training was available for army medical practitioners. With the simultaneous rapid advance of French military and civilian medical training and the threat of a French invasion, regulating British medical training and excluding the unqualified became a military necessity, and suddenly medical reform was receiving widespread attention. Emphasising the benefits to the Britain’s fighting ability, the reform effort, led by Edward Harrison, a very provincial Lincolnshire physician, under the patronage of Sir Joseph Banks, the President of the Royal Society, gained the support of leading politicians, including three Prime Ministers. For a short time, comprehensive medical reform seemed inevitable: but the opposition of the medical corporations, especially the London College of Physicians, could not be circumvented, and although Harrison persisted in his efforts for 6 years, no legislation was achieved. Nevertheless, within months, the Association of Apothecaries continued the process by pressing for a more limited reform, culminating in the 1815 Apothecaries Act. The long march towards the full regulation of doctors in Britain was started by the perceived military needs of the country during the war with France.
Expectations, values, preferences and experiences of Hungarian primary care population when accessing services: Evaluation of the patient’s questionnaires of the international QUALICOPC study
Authors: Nánási Anna , Ungvári Tímea , Kolozsvári László R. , Harsányi Szilvia , Jancsó Zoltán , Lánczi Levente I. , Mester Lajos , Móczár Csaba , Semanova Csilla , Schmidt Péter , Szidor Judit , Torzsa Péter , Végh Mária , Rurik Imre 
Published: June 2021

Abstract

Background:
Preferences and wishes of patients is an important indicator of primary health care provision, although there are differences between national primary care systems.

Aim:
The aim of this paper is to describe and evaluate the preferences and values of Hungarian primary care (PC) patients before accessing and to analyse their experiences after attending PC services.

Methods:
In the Hungarian arm of the European QUALICOPC Study, in 2013–2014, information was collected with questionnaires; the Patient Values contained 19 and the Patient Experiences had 41 multiple-choice questions.

Findings:
The questionnaires were filled by 2149 (840 men, 1309 women) using PC services, aged 49.1 (SD ± 16.7) years, 73% of them having chronic morbidities. Women preferred to be accompanied and rated their own health better. Patients in the lowest educational category and women visited their GPs more often, and they are consulted more frequently by other doctors as well. Men, older and secondary educated people reported more frequently chronic morbidities. Longer opening hours were preferred by patients with higher education. The most preferred expectations were availability and polite communication of doctors, not pressures on consultation time, clear instructions provided during consultations, shared decisions about treatments and options for consultations, the knowledge of the doctors concerning the living conditions, social and cultural backgrounds of patients, updated medical records, short waiting times, options for home visits, wide scope of professional competences and trust in the doctor.

Conclusion:
Wishes, preferences of patients and fulfilment were similar than described in other participating countries of the study. Although there are room to improve PC services, most of the questioned population were satisfied with the provision.
Cosmic connections: James Croll's influence on his contemporaries and his successors
Authors: FLEMING James R. 
Published: June 2021

ABSTRACTThis paper examines the astronomical theory of ice ages of James Croll (1821–1890), its influence on contemporaries John Tyndall, Charles Lyell, and Charles Darwin, and the subsequent development of climate change science, giving special attention to the work of Svante Arrhenius, Nils Ekholm, and G. S. Callendar (for the carbon dioxide theory), and Milutin Milanković (for the astronomical theory). Croll's insight that the orbital elements triggered feedbacks leading to complex changes – in seasonality, ocean currents, ice sheets, radiative forcing, plant and animal life, and climate in general – placed his theory of the Glacial Epoch at the nexus of astronomy, terrestrial physics, and geology. He referred to climate change as the most important problem in terrestrial physics, and the one which will ultimately prove the most far reaching in its consequences. He was an autodidact deeply involved in philosophy and an early proponent of what came to be called ‘cosmic physics’ – later known as ‘Earth-system science.’ Croll opened up new dimensions of the ‘climate controversy’ that continue today in the interplay of geological and human influences on climate.