bluuebunny/crossref_metadata_2025_split huggingface dataset:
DEVELOPMENT OF METHODS FOR ASSESSMENT AND ANALYSIS OF INVESTMENT ATTRACTIVENESS IN SUBJECTS OF THE RUSSIAN FEDERATION
Authors: Шпехт Любовь Ивановна 
Published: September 2021

В данной статье проанализированы методы оценки и анализа инвестиционной привлекательности в субъектах Российской Федерации. Проведено сравнение различных методов оценки инвестиционной привлекательности регионов и предложено оптимальное применения данных методов.This article analyzes methods for assessing and analyzing investment attractiveness in the constituent entities of the Russian Federation. A comparison of various methods for assessing the investment attractiveness of regions is carried out and the optimal application of these methods is proposed.
Better self-concept, better future choices? Behavioral and neural changes after a naturalistic self-concept training program for adolescents
Authors: Van der Aar L. P. E. , Peters S. , Becht A. I. , Crone E. A. 
Published: September 2021

AbstractA large number of adolescents experience difficulty when choosing a suitable higher education program that matches their self-views. Stimulating self-concept development could help adolescents to increase their chances of finding a suitable major. We addressed this issue by examining the effects of a naturalistic self-concept training within a gap year context on behavioral and neural correlates of self-evaluations, as well as the long-term effects for future educational decision-making. In total, 38 adolescents/young adults (ages 16-24 years) participated in a 4-wave longitudinal study, with lab visits before, during, and after the training, including behavioral assessments and fMRI. During fMRI-scanning, they rated themselves on positive and negative traits in academic, (pro)social, and physical domains, and additionally filled out questionnaires related to self-esteem and self-concept clarity. Results showed that the positivity of domain-specific self-evaluations, self-esteem, and self-concept clarity increased during the training. Second, participants with lower medial PFC activity during self-evaluation before training showed larger self-esteem increases over the year. Moreover, mPFC activity increased after training for the evaluation of positive but not negative traits. Furthermore, individual differences in the rate of change (slope) in self-concept clarity and social self-evaluations positively predicted social adjustment to college and academic performance 6 months after training. Together, these findings suggest that self-concept can be modulated in late adolescents, with an important role of the medial PFC in relation to enhanced positive self-evaluations, and self-concept clarity as a predictor of future educational outcomes.
Taxonomy notes and new occurrence data of four species of atyid shrimp (Crustacea: Decapoda: Atyidae) in Vietnam, all described from China
Authors: Tu Do Van , von Rintelen Kristina , Klotz Werner , Hung Anh Le , Anh Tuan Tran , Van Dong Dang , Thi Yen Phan , Tong Cuong Nguyen , Ngoc Khac Hoang , Dang Phan , von Rintelen Thomas 
Published: September 2021

Freshwater shrimp of the family Atyidae De Haan, 1849 have been studied in Vietnam for more than a century. A total of 24 species of atyid shrimps from the generaCaridinaH. Milne Edwards, 1837,NeocaridinaKubo, 1938,AtyopsisChace, 1983 have been recorded from Vietnam. With 22 species, the majority are from the genusCaridina. In 2013, Karge and Klotz mentioned the occurrence of four yet undescribed species belonging toParacaridinaLiang, Guo &amp; Tang, 1999 in Vietnam without taxonomic details.In general, studies of freshwater atyids in Vietnam are limited and most Vietnamese taxa await a taxonomic revision. The available data do not fully reflect their estimated species diversity in the country and distribution data are deficient. Here, we focus on four species of atyid shrimps from two genera, viz.Caridina cantonensisYu, 1938,C. lanceifronsYu, 1936,C. serrataStimpson, 1860 andNeocaridina palmata(Shen, 1948), all described from China and have been reported to occur in Vietnam. The previous reports on the occurrence of these species in Vietnam are largely unreliable due to taxonomic confusion. To contribute to the knowledge of these taxa, we provide the first verified distribution records of the four species in the country with some taxonomic remarks.This study shows the first taxonomically-verified distribution data of four atyid shrimp species originally described from China, but also reported from Vietnam, albeit under various species names and, in some cases, erroneously. These data allow the first meaningful discussion of the distribution in light of the reproductive strategy of these four species and, in conjunction with the taxonomic remarks, will contribute to the knowledge of these taxa. As a result of this research and data from previous studies, we now consider all four species as widespread and non-endemic, but land-locked (with a complete freshwater life cycle). In Vietnam, all four species are confined to the northern half of the country. Beyond Vietnam, we provide the first records forCaridina lanceifronsfrom southern Thailand, which suggests a major sampling gap in Indochina.
ERAP1 Controls the Autoimmune Response against Melanocytes in Psoriasis by Generating the Melanocyte Autoantigen and Regulating Its Amount for HLA-C*06:02 Presentation
Authors: Arakawa Akiko , Reeves Emma , Vollmer Sigrid , Arakawa Yukiyasu , He Mengwen , Galinski Adrian , Stöhr Julia , Dornmair Klaus , James Edward , Prinz Jörg C 
Published: September 2021

Abstract
Autoimmune diseases develop when autoantigens activate previously quiescent self-reactive lymphocytes. Gene–gene interaction between certain HLA class I risk alleles and variants of the endoplasmic reticulum aminopeptidase ERAP1 controls the risk for common immune-mediated diseases, including psoriasis, ankylosing spondylitis, and Behçet disease. The functional mechanisms underlying this statistical association are unknown. In psoriasis, HLA-C*06:02 mediates an autoimmune response against melanocytes by autoantigen presentation. Using various genetically modified cell lines together with an autoreactive psoriatic TCR in a TCR activation assay, we demonstrate in this study that in psoriasis, ERAP1 generates the causative melanocyte autoantigen through trimming N-terminal elongated peptide precursors to the appropriate length for presentation by HLA-C*06:02. An ERAP1 risk haplotype for psoriasis produced the autoantigen much more efficiently and increased HLA-C expression and stimulation of the psoriatic TCR by melanocytes significantly more than a protective haplotype. Compared with the overall HLA class I molecules, cell surface expression of HLA-C decreased significantly more upon ERAP1 knockout. The combined upregulation of ERAP1 and HLA-C on melanocytes in psoriasis lesions emphasizes the pathogenic relevance of their interaction in patients. We conclude that in psoriasis pathogenesis, the increased generation of an ERAP1-dependent autoantigen by an ERAP1 risk haplotype enhances the likelihood that autoantigen presentation by HLA-C*06:02 will exceed the threshold for activation of potentially autoreactive T cells, thereby triggering CD8+ T cell–mediated autoimmune disease. These data identify ERAP1 function as a central checkpoint and promising therapeutic target in psoriasis and possibly other HLA class I–associated diseases with a similar genetic predisposition.
Evaluation of the effect of preoperative corneal curvature on the successful formation of the big bubble formation in deep anterior lamellar keratoplasty for keratoconus
Authors: Hassan Mohamed S. , Elmassry Ahmed A. , Ghaith Alaa A. , Goweida Mohamed B. 
Published: September 2021

Background
New approaches have been created to raise the chances of achieving big bubble (BB) in deep anterior lamellar keratoplasty (DALK); however, the BB formation is still uncertain in all cases. Other factors likely contribute to the success of bubble formation.

Aim
To evaluate the effect of preoperative curvature of the cornea on the success of BB formation in DALK for keratoconus.

Design
A prospective, comparative, nonrandomized study.

Patients and methods
The study was performed on 50 keratoconus patients. We compared the data of 25 patients who had successful type-1 bubble formation versus another 25 patients in whom the bubble formation failed. Both groups were compared regarding the keratometric readings recorded from the preoperative pentacam.

Results
The analysis showed statistically significant lower K1, K2, and Km values in the group where BB has been successfully achieved. We also found that lower K1 value was the only significant studied factor after the multivariate analysis.

Conclusion
Keratoconus patients with preoperative flatter corneas have slightly higher chances for successful BB formation during DALK surgery.
Identification of adulterants of Terminalia arjuna bark from market samples through a pharmacognostical study
Authors: Mallikarjuna Rao Polepalli , Gupta K. L. Virupaksha 
Published: September 2021

Background:
Pharmacognostical parameters, namely macroscopic and microscopic techniques, are very important in the identification of drugs. The macroscopic and microscopic feature of medicinal plants is believable, accurate and involves less cost. So, the study of the morphology and the organoleptic nature of drugs is undertaken using highly sophisticated modern techniques. In Ayurveda, Arjuna bark is an important drug for the treatment of heart disorders and other diseases. There is a great demand for Arjuna bark in the market, and it is very prone to getting adulterated. To find out the correct identity of Arjuna bark from adulterants with the help of pharmacognostical techniques, the present study was undertaken.

Materials and Methods:
The Arjuna bark was obtained from the source tree and from four raw drug markets of the capital cities of south India. These five Arjuna bark samples were considered for analyzing their organoleptic characteristics; microscopic examination, polarization, fluorescence microscopic examination, powder microscopy, and thin layer chromatography (TLC) of the drug were used for authentication.

Results:
The Arjuna bark collected from the source tree and the market samples showed the same presentations, thus the market samples were acceptable. It is also found that the bark of the tree Terminalia paniculata is used as an adulterant in a negligible quantity.

Conclusion:
The present study reveals that, the chances of adulteration for T. arjuna are very less.
A review on the pharmacological properties of Evolvulus alsinoides (Linn)
Authors: Kathirvel Bharathi , Kalibulla Syed I. , Shanmugam Velayuthaprabhu , Arumugam Vijaya A. 
Published: September 2021

Background:

Evolvulus alsinoides (Linn) is a perennial herb found throughout India that belongs to the family of Convolvulaceae. Shankhpushpi was traditionally used in Unani and Ayurveda. Shankhpushpi was used in the Medhya Rasyana (nervine tonic) as a brain and memory tonic. Traditionally, Shankhpushpi has been used as a memory enhancer, a sedative; for antianxiety; as an antiepileptic, anthelmintic, and anticonvulsant; and against leukoderma.

Aim:
The objective of this review is to summarize the phytochemical constituents, traditional uses, ethnomedicinal uses, and pharmacological properties of E. alsinoides L.

Materials and Methods:
The articles regarding E. alsinoides L. were collected using keywords such as E. alsinoides L.; pharmacological activities and traditional usage were obtained from accredited scientific databases such as Pubmed, Nature, Wiley, Springer, and ScienceDirect.

Results and Conclusion:
Based on current observations, a literature review suggested that the E. alsinoides L. may possess pharmacological properties such as wound healing, hepatoprotective activity, cardioprotective property, antidiabetic activity, memory and learning, and neuroprotective activity.
Effectiveness of WHO dengue management protocol
Authors: Rajan Nishanth , Jose Priya , Kommu Peter Prasanth Kumar , Mani Manikandan , Krishnan Lalitha 
Published: September 2021

Background:
Dengue fever (DF) has become a worldwide health problem. There are only a few studies assessing management based on the classification by the World Health Organization (WHO). Hence, we aimed at assessing the outcome of children with DF before and after the implementation of the WHO protocol.

Subjects and Methods:
A retrospective hospital-based comparative study was done in a tertiary care center, Puducherry, to study the outcome of children diagnosed with DF before and after the implementation of WHO management 2012 protocol in the year 2014. All children (0–14 years) who were diagnosed with DF (NS1Ag or IgM ELISA positivity) during 2012–2016 were included. Medical records with incomplete data were excluded. They were divided into two groups: Group I – Children admitted for treatment of DF between January 2012 and December 2013 (24 months) and managed by close clinical monitoring and Group II – Children admitted for treatment of DF between January 2014 and December 2016 (36 months) and managed as per WHO protocol.

Results:
There was no statistically significant difference in the signs of shock and mortality between the groups. There was statistically significant difference of children with fluid overload during the recovery phase in Group II when compared with Group I.

Conclusions:
Close clinical monitoring during the critical phase may reduce the signs of fluid overload during the recovery phase.
Toll-Like Receptors and Mannose Binding Lectin Gene Polymorphisms Associated with Cryptosporidial Diarrhea in Children in Southern India
Authors: Liakath Farzana Begum , Varatharajan Savitha , Premkumar Prasanna Samuel , Syed Chanduni , Ward Honorine , Kang Gagandeep , Ajjampur Sitara S. R. 
Published: September 2021

ABSTRACT.
In low-resource settings, Cryptosporidium spp. is a common cause of diarrheal disease in children under the age of 3 years. In addition to diarrhea, these children also experience subclinical episodes that have been shown to affect growth and cognitive function. In this study, we screened polymorphisms in the promoter and exon1 regions of the mannose binding lectin 2 (MBL2) gene, as well as single nucleotide polymorphisms (SNPs) described in toll-like receptors (TLR) TLR1, TLR2, TLR4, and TLR9 and TIR domain-containing adaptor protein (TIRAP) genes among children with cryptosporidial diarrhea (cases) and children who only experienced asymptomatic (subclinical) cryptosporidiosis (controls). Among the polymorphisms screened, the variant allele B at codon 54 (rs1800450) of the MBL2 gene was associated with susceptibility to cryptosporidial diarrhea (odds ratio [OR] = 2.2, 95% confidence interval [CI] 1.1–4.5). When plasma MBL levels were compared, 72% of cases were found to be deficient compared with 32% among controls (OR = 5.09). Among TLR polymorphisms screened, multivariate analysis showed that heterozygous genotypes of TLR4 896A/G (rs4986790, OR = 0.33, 95% CI: 0.11–0.98) and TIRAP 539 C/T (rs8177374, OR = 0.19, 95% CI: 0.06–0.64) SNPs were associated with protection from cryptosporidial diarrhea. Although not statistically significant, these findings suggest that polymorphisms of MBL2 and TLR genes influence susceptibility to symptomatic cryptosporidial diarrhea even in settings with high exposure levels. Further studies to validate these findings in a larger cohort and to understand the role of these polymorphisms in mediating innate and adaptive immune responses to cryptosporidial infection are necessary.
Contribution of Viral Respiratory Infections to Dengue-Like Illness Presentation at a Community Clinic in Southern Malaysia
Authors: Dhanoa Amreeta , Ngim Chin Fang , Yunos Nor’azim Mohd , Husain Syed M. Tupur , Pong Lian Yih , Ismail Wan Fadhilah Wan , Hontz Robert D. , Hassan Sharifah Syed 
Published: September 2021

ABSTRACT.
This study explored the contribution of viral respiratory infections (VRIs) in dengue-like illness (DLI) patients and their distinguishing clinicolaboratory parameters. Two hundred DLI patients were prospectively recruited (July 1– October 1, 2019) from a community clinic in Southern Malaysia. Patients ≥ 18 years with acute fever and fulfilling the WHO criteria of probable dengue were recruited. They underwent blood testing: blood counts, rapid dengue tests (nonstructural antigen-1/IgM) and polymerase chain reaction (PCR) for dengue, Zika, chikungunya, and Leptospira. Nasopharyngeal swabs (NPSs) were collected for FilmArray®RP2plus testing. From the 200 NPSs, 58 respiratory viruses (RVs) were detected in 54 patients. Of the 96 dengue-confirmed cases, 86 had dengue mono-infection, and 10 were coinfected with RVs. Of the 104 nondengue, 44 were RV positive and 4 Leptospira positive. Zika and chikungunya virus were not detected. Overall, the etiological diagnosis was confirmed for 72% of patients. Clinicolaboratory parameters were compared between dengue mono-infection and VRI mono-infection. Patients with coinfections were excluded. Multiple logistic regression showed that recent household/neighborhood history of dengue (adjusted odds ratio [aOR]: 5.9, 95% CI = 1.7–20.7), leukopenia (aOR: 12.5, 95% CI = 2.6–61.4) and thrombocytopenia (aOR: 5.5, 95% CI = 1.3–23.0) predicted dengue. Inversely, rhinorrhoea (aOR: 0.1, 95% CI = 0.01–0.3) and cough (aOR: 0.3, 95% CI = 0.1–0.9) favored VRI. Thus, VRIs comprise many infections diagnosed initially as DLIs. Early clinicolaboratory parameters can guide physicians screen patients for further testing.
PENGARUH NON PERFORMING FINANCING DAN CAPITAL ADEQUACY RATIO TERHADAP RETURN ON ASSET PADA BANK JABAR BANTEN SYARIAH
Authors: Marismiati Marismiati 
Published: September 2021

Non performing financing merupakan rasio perbandingan antara pembiayaan bermasalah dengan total pembiayaan, sedangkan capital adequacy ratio merupakan perbandingan antara modal dengan aset tertimbang menurut resiko. Return on asset merupakan rasio Profitabilitas yang digunakan untuk mengukur kemampuan perusahaan memperoleh laba sebelum pajak dari keseluruhan aset yang dimiliki. Metode pengumpulan data dalam penelitian ini adalah Purposive Sampling dengan kriteria yang telah ditentukan dengan sampel laporan keuangan triwulan dari tahun 2011-2018 sebanyak 32 data. Analisis data yang digunakan dalam penelitian ini adalah analisis Korelasi Berganda, Regresi Linear Berganda ,Koefisien Determinasi, Uji t dan Uji F. Hasil penelitian ini menunjukan bahwa secara parsial non performing financing tidak berpengaruh signifikan terhadap return on asset, secara parsial capital adequacy ratio tidak berpengaruh signifikan terhadap capital adequacy ratio, kemudian secara simultan non performing financing dan capital adequacy ratio tidak berpengaruh signifikan terhadap return on asset.
Healing words - emotional intelligence, the role of communication in the relationship with hypoacusic children
Authors: Stănescu Nina , Tasențe Tănase 
Published: September 2021

Wilbur Schramm understands by communication "the process of sending a message and transmitting it in a coded manner using a channel to a recipient for reception". All living bodies communicate with each other, and in society, communication is the paradigm of all human activities; everything that is subscribed to the human being has communicative and communicational connotations. The formation of the individual as a human being can be achieved only in his permanent interaction with others. This interaction is facilitated by the gregarious instinct of man, which is translated into a continuous search for the company of others.
Hamefura o cómo vivir en un juego otome y no morir en el intento
Authors: Gutiérrez Montañés María 
Published: September 2021

<p>El siguiente artículo se aproxima a la serie de animación japonesa Hamefura (Keisuke Inoue, 2020), una adaptación de una saga de novelas ligeras a manos de la autora Yamaguchi Satoru, que narra las andanzas de Catarina Claes y su renacimiento en un nuevo mundo basado en un juego otome llamado Fortune Lover. Así, en primer lugar, llevaremos a cabo una definición de estos juegos, así como del género isekai, en el que se enmarca esta serie, para después detenernos en un análisis completo de los préstamos y características propias de este tipo de juegos que se representan a lo largo de la primera temporada de Hamefura, poniendo de relieve lo sobresaliente de esta adaptación que poco tiene que ver con lo que se ha hecho hasta el momento en relación con estas novelas visuales.</p><p> </p>
Anti-ovarian cancer and collagenase, α-amylase, and aldose reductase inhibition properties of 2'-hydroxy-5'-methoxyacetophenone with molecular modeling studies
Authors: Wang Li , Zhi Yuanyuan 
Published: September 2021

IntroductionThis work investigated the inhibition effect of 2'-hydroxy-5'-methoxyacetophenone on aldose reductase, α-amylase, and also collagenase enzymes. Also, molecular modeling calculations were performed comparing the biochemical activity of the 2'-hydroxy-5'-methoxyacetophenone molecule with these enzymes.Material and methodsThe enzymes used in these calculations are aldose reductase (AR), α-amylase (Alpha-Amy), and collagenase from Clostridium histolyticum (Coll). After the docking calculations were performed, ADME/T analysis parameters were examined in order to calculate the properties of the methoxyacetophenone molecule to be utilized as a drug in the future. For determining anti-ovarian cancer properties of 2'-hydroxy-5'-methoxyacetophenone, the MTT assay was used on normal (HUVEC), PA-1, Caov-3, and SK-OV-3 cell lines.ResultsThe IC50 values of 2'-hydroxy-5'-methoxyacetophenone against PA-1, Caov-3, and SK-OV-3 cell lines were found to be 271, 326 and 405 µg/ml, respectively.Conclusions2'-hydroxy-5'-methoxyacetophenone was found to have significant antioxidant and anti-ovarian cancer properties. It appears that the anti-ovarian cancer effect of 2'-hydroxy-5'-methoxyacetophenone is due to its antioxidant effects.
PENGELOLAAN SUPERVISI KLINIS PENGAWAS , PENDEKATAN “PAS” BAGI PENINGKATAN KINERJA GURU TIPE GURU (ANALYTICAL OBSERVER)
Authors: SA’IDU NUR 
Published: September 2021

Penelitian ini mendeskripsikan tentang supervisi klinis pengawas dengan pendekatan Persuasi, Analisis, Solusi (PAS) di masa pandemi covid-19 dalam pemecahan masalah guru Tipe (Analytical Observer ) di Madrasah binaan Kecamatan Bringin Kabupaten Semarang Jawa Tengah. Jenis Penelitian kualitatif dengan sifat deskriptif dipergunakan dalam penelitian ini . Pengumpulan data dilakukan melalui wawancara mendalam, observasi, dokumentasi dan kuesioner (survey). Pemeriksaan data menggunakan teknik triangulasi untuk memastikan bahwa data memenuhi kredibilitas. Sedangkan data dianalisis dengan mempergunakan model Miles dan Huberman yang terdiri dari reduksi data, bagaimana data disajikan dan apa kesimpulannya. Hasil penelitian menggambarkan bahwa implementasi supervisi klinis masih dapat dilakukan di tengah pandemi covid-19 dengan memodifikasi teknik supervisi klinis. Dan pada akhirnya, supervisi klinis yang dilakukan dapat memberikan bimbingan dan motivasi bagi guru untuk memecahkan masalah kinerja dalam pembelajaran. Pendekatan PAS supervisi klinis pengawas mengedepankan proses kolaborasi kemitraan bukan mencari cari kesalahan guru, tetapi melalui diagnosis dan analisis dirinya sendiri (self eficacy) untuk menemukan dirinya sendiri, penerimaan diri atas kemampuannya sehingga timbul motivasi dalam dirinya dalam mencari solusi atas hambatan persoalan dalam pembelajarannya guna memperbaiki dirinya dalam meningkatkan kinerja dan kualitas pembelajaran secara maksimal.