bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship between duty factor and external forces in slow recreational runners
Authors: Bonnaerens Senne , Fiers Pieter , Galle Samuel , Derie Rud , Aerts Peter , Frederick Edward , Kaneko Yasunori , Derave Wim , De Clercq Dirk , Segers Veerle 
Published: March 2021

ObjectivesRecreational runners show a large interindividual variation in spatiotemporal characteristics. This research focused on slow runners and intended: (1) to document the variance in duty factor (DF) between runners in a real-life running setting and (2) examine whether the interindividual variation in DF and stride frequency (SF) relates to differences in external loading parameters between runners.MethodsSpatiotemporal characteristics of 23 slow runners (ie, <2.6 m/s) were determined during a 5.2 km running event. To relate the interindividual variation in DF and SF to differences in external forces between runners (maximal vertical ground reaction force (FzMax), peak braking force (PBF) and vertical instantaneous loading rate (VILR)), 14 of them were invited to the lab. They ran at 1.9 m/s on a treadmill while ground reaction forces were recorded. A multiple linear regression analysis was conducted to investigate the effect of DF and SF on external force measures.ResultsDF between slow runners varied from 42.50% to 56.49% in a recreational running event. DF was found to be a significant predictor of FzMax (R²=0.755) and PBF (R²=0.430). SF only improved the model for PBF, but to a smaller extent than DF (R² change=0.191). For VILR, neither DF nor SF were significant predictors.ConclusionExternal forces are lower in recreational runners that run with higher DFs and slightly lower SFs. These findings may be important for injury prevention purposes, especially directed to recreational runners that are more prone to overuse injuries.
RNA tape sampling in cutaneous lupus erythematosus discriminates affected from unaffected and healthy volunteer skin
Authors: Merola Joseph F , Wang Wenting , Wager Carrie G , Hamann Stefan , Zhang Xueli , Thai Alice , Roberts Christopher , Lam Christina , Musselli Cristina , Marsh Galina , Rabah Dania , Barbey Catherine , Franchimont Nathalie , Reynolds Taylor L 
Published: March 2021

ObjectivePunch biopsy, a standard diagnostic procedure for patients with cutaneous lupus erythematosus (CLE) carries an infection risk, is invasive, uncomfortable and potentially scarring, and impedes patient recruitment in clinical trials. Non-invasive tape sampling is an alternative that could enable serial evaluation of specific lesions. This cross-sectional pilot research study evaluated the use of a non-invasive adhesive tape device to collect messenger RNA (mRNA) from the skin surface of participants with CLE and healthy volunteers (HVs) and investigated its feasibility to detect biologically meaningful differences between samples collected from participants with CLE and samples from HVs.MethodsAffected and unaffected skin tape samples and simultaneous punch biopsies were collected from 10 participants with CLE. Unaffected skin tape and punch biopsies were collected from 10 HVs. Paired samples were tested using quantitative PCR for a candidate immune gene panel and semi-quantitative immunohistochemistry for hallmark CLE proteins.ResultsmRNA collected using the tape device was of sufficient quality for amplification of 94 candidate immune genes. Among these, we found an interferon (IFN)-dominant gene cluster that differentiated CLE-affected from HV (23-fold change; p<0.001) and CLE-unaffected skin (sevenfold change; p=0.002), respectively. We found a CLE-associated gene cluster that differentiated CLE-affected from HV (fourfold change; p=0.005) and CLE-unaffected skin (fourfold change; p=0.012), respectively. Spearman’s correlation between per cent area myxovirus 1 protein immunoreactivity and IFN-dominant mRNA gene cluster expression was highly significant (dermis, rho=0.86, p<0.001). In total, skin tape-derived RNA expression comprising both IFN-dominant and CLE-associated gene clusters correlated with per cent area immunoreactivity of some hallmark CLE-associated proteins in punch biopsies from the same lesions.ConclusionsA non-invasive tape RNA collection technique is a potential tool for repeated skin biomarker measures throughout a clinical trial.
Topological strings on toric geometries in the presence of Lagrangian branes
Authors: Muteeb M. Nouman 
Published: March 2021

AbstractWe propose expressions for refined open topological string partition function on certain non-compact Calabi Yau 3-folds with topological branes wrapped on the special lagrangian submanifolds. The corresponding web diagrams are partially compact and a lagrangian brane is inserted on one of the external legs. Partial compactification introduces a mass deformation in the corresponding gauge theory. We propose conjectures that equate these open topological string partition functions with the generating function of equivaraint indices on certain quiver moduli spaces. To obtain these conjectures we use the identification of topological string partition functions with equivariant indices on the instanton moduli spaces.
Hydrophobic antireflective coating with high laser damage threshold by physical vapor deposition
Authors: Wang Jianguo , Feng Cao , Zhang Weili , Xu Ziyuan , Liu Xiaofeng , Yi Kui , Shao Jianda 
Published: March 2021

Hydrophobic antireflective coating is fabricated by physical vapor deposition. The optical, contact angle and laser damage resistance properties are investigated, respectively. The transmittance of the antireflective coating with hydrophobic layer is 99.58% at 1064 nm with normal incidence. The contact angle with water is 115.6[Formula: see text]. The laser damage threshold of the zero probability is 22 J/cm2at 1064 nm with the 12 ns pulse width. This new hydrophobic antireflective coating can be applied in the areas of astronomical optics, laser medical equipment and solar energy, etc.
Coherence Between Brain Activation and Speech Envelope at Word and Sentence Levels Showed Age-Related Differences in Low Frequency Bands
Authors: Kolozsvári Orsolya B. , Xu Weiyong , Gerike Georgia , Parviainen Tiina , Nieminen Lea , Noiray Aude , Hämäläinen Jarmo A. 
Published: March 2021

Abstract
Speech perception is dynamic and shows changes across development. In parallel, functional differences in brain development over time have been well documented and these differences may interact with changes in speech perception during infancy and childhood. Further, there is evidence that the two hemispheres contribute unequally to speech segmentation at the sentence and phonemic levels. To disentangle those contributions, we studied the cortical tracking of various sized units of speech that are crucial for spoken language processing in children (4.7–9.3 years old, N = 34) and adults (N = 19). We measured participants’ magnetoencephalogram (MEG) responses to syllables, words, and sentences, calculated the coherence between the speech signal and MEG responses at the level of words and sentences, and further examined auditory evoked responses to syllables. Age-related differences were found for coherence values at the delta and theta frequency bands. Both frequency bands showed an effect of stimulus type, although this was attributed to the length of the stimulus and not the linguistic unit size. There was no difference between hemispheres at the source level either in coherence values for word or sentence processing or in evoked response to syllables. Results highlight the importance of the lower frequencies for speech tracking in the brain across different lexical units. Further, stimulus length affects the speech–brain associations suggesting methodological approaches should be selected carefully when studying speech envelope processing at the neural level. Speech tracking in the brain seems decoupled from more general maturation of the auditory cortex.
Monthly Modulations of ENSO Teleconnections: Implications for Potential Predictability in North America
Authors: Chapman William E. , Subramanian Aneesh C. , Xie Shang-Ping , Sierks Michael D. , Ralph F. Martin , Kamae Youichi 
Published: March 2021

AbstractUsing a high-resolution atmospheric general circulation model simulation of unprecedented ensemble size, we examine potential predictability of monthly anomalies under El Niño Southern Oscillation (ENSO) forcing and back-ground internal variability. This study reveals the pronounced month-to-month evolution of both the ENSO forcing signal and internal variability. Internal variance in upper-level geopotential height decreases (∼ 10%) over the North Pacific during El Niño as the westerly jet extends eastward, allowing forced signals to account for a greater fraction of the total variability, and leading to increased potential predictability. We identify February and March of El Niño years as the most predictable months using a signal-to-noise analysis. In contrast, December, a month typically included in teleconnection studies, shows little-to-no potential predictability. We show that the seasonal evolution of SST forcing and variability leads to significant signal-to-noise relationships that can be directly linked to both upper-level and surface variable predictability for a given month. The stark changes in forced response, internal variability, and thus signal-to-noise across an ENSO season indicate that subseasonal fields should be used to diagnose potential predictability over North America associated with ENSO teleconnections. Using surface air temperature and precipitation as examples, this study provides motivation to pursue ‘windows of forecast opportunity’, in which statistical skill can be developed, tested, and leveraged to determine times and regions in which this skill may be elevated.
Correcting Observational Biases in Sea Surface Temperature Observations Removes Anomalous Warmth during World War II
Authors: Chan Duo , Huybers Peter 
Published: March 2021

AbstractMost historical sea surface temperature (SST) estimates indicate warmer World War II SSTs than expected from forcing and internal climate variability. If real, this World War II warm anomaly (WW2WA) has important implications for decadal variability, but the WW2WA may also arise from incomplete corrections of biases associated with bucket and engine room intake (ERI) measurements. To better assess the origins of the WW2WA, we develop five different historical SST estimates (reconstructions R1–R5). Using uncorrected SST measurements from the International Comprehensive Ocean–Atmosphere Data Set (ICOADS) version 3.0 (R1) gives a WW2WA of 0.41°C. In contrast, using only buckets (R2) or ERI observations (R3) gives WW2WAs of 0.18° and 0.08°C, respectively, implying that uncorrected biases are the primary source of the WW2WA. We then use an extended linear-mixed-effect method to quantify systematic differences between subsets of SSTs and develop groupwise SST adjustments based on differences between pairs of nearby SST measurements. Using all measurements after applying groupwise adjustments (R4) gives a WW2WA of 0.13°C [95% confidence interval (c.i.): 0.01°–0.26°C] and indicates that U.S. and U.K. naval observations are the primary cause of the WW2WA. Finally, nighttime bucket SSTs are found to be warmer than their daytime counterparts during WW2, prompting a daytime-only reconstruction using groupwise adjustments (R5) that has a WW2WA of 0.09°C (95% c.i.: −0.01° to 0.18°C). R5 is consistent with the range of internal variability found in either the CMIP5 (95% c.i.: −0.10° to 0.10°C) or CMIP6 ensembles (95% c.i.: −0.11° to 0.10°C). These results support the hypothesis that the WW2WA is an artifact of observational biases, although further data and metadata analyses will be important for confirmation.
Transcranial Magnetic Stimulation (TMS) during pregnancy: a fetal risk factor
Authors: Pridmore Saxby , Turnier-Shea Yvonne , Rybak Marzena , Pridmore William 
Published: March 2021

Objective: To examine reports of Transcranial Magnetic Stimulation (TMS) during pregnancy for evidence of fetal risk. Method: PubMed was used to locate relevant literature for the years 1998–2020 and reference lists were examined for materials not located electronically. Results: Ten reports were located dealing with 67 births over 20 years. Stimulation was applied is all trimesters, at low and high frequency, and as intermittent theta-burst stimulation. No mother or baby experienced a serious event. Conclusions: Certainty awaits large, standardized studies. However, the available reports provide no evidence that TMS to mother during pregnancy has detrimental effects on the fetus.
Facial conformation characteristics in Persian and Exotic Shorthair cats
Authors: Anagrius Kerstin L , Dimopoulou Maria , Moe Anna N , Petterson Ann , Ljungvall Ingrid 
Published: March 2021

Objectives The primary objectives of the study were to examine the diversity in facial conformation characteristics within a group of Persian (PER) and Exotic Shorthair (EXO) show cats, and to contrast the results to findings within a group of non-purebred domestic shorthair (DSH) and domestic longhair (DLH) cats. The secondary objectives were to determine the PER/EXO show cat owners’ perceptions of the breathing status of their cats, and to evaluate if remarks from the cat show judges concerning the cats’ head and facial conformation were exclusively related to the aesthetic features of the cats. Methods Sixty-four PER and 12 EXO show cats were prospectively examined at five international cat shows, and 20 DSH/DLH cats were examined at an animal hospital. Facial conformation characteristics were evaluated by examining photos of the cats. Owners of the PER/EXO show cats answered a questionnaire concerning their cats’ health status, and they were encouraged to send in the judges’ score sheets from the cat shows. Results The PER/EXO show cats had higher diversity in facial conformation characteristics than the DSH/DLH cats, and high incidences of hypoplasia of the nose leather (95%), the nose leather top positioned above the level of the lower eyelid (93%), moderate-to-severe stenotic nares (86%), epiphora (83%) and entropion (32%). Owners of 6/76 PER/EXO show cats stated that their cat had increased respiratory sounds and/or trouble breathing at least once a week. The cat show judges’ written comments were exclusively related to aesthetic features of the cats’ head and facial conformation details. Conclusions and relevance Hypoplasia of the nose leather, high position of the nose leather top, stenotic nares, epiphora and entropion were common findings in the PER/EXO show cats but not in the DSH/DLH cats. Few of the cat owners perceived that their cat had problems related to the airways.
Structural brain network characteristics in patients with episodic and chronic migraine
Authors: Michels Lars , Koirala Nabin , Groppa Sergiu , Luechinger Roger , Gantenbein Andreas R. , Sandor Peter S. , Kollias Spyros , Riederer Franz , Muthuraman Muthuraman 
Published: March 2021

AbstractBackgroundMigraine is a primary headache disorder that can be classified into an episodic (EM) and a chronic form (CM). Network analysis within the graph-theoretical framework based on connectivity patterns provides an approach to observe large-scale structural integrity. We test the hypothesis that migraineurs are characterized by a segregated network.Methods19 healthy controls (HC), 17 EM patients and 12 CM patients were included. Cortical thickness and subcortical volumes were computed, and topology was analyzed using a graph theory analytical framework and network-based statistics. We further used support vector machines regression (SVR) to identify whether these network measures were able to predict clinical parameters.ResultsNetwork based statistics revealed significantly lower interregional connectivity strength between anatomical compartments including the fronto-temporal, parietal and visual areas in EM and CM when compared to HC. Higher assortativity was seen in both patients’ group, with higher modularity for CM and higher transitivity for EM compared to HC. For subcortical networks, higher assortativity and transitivity were observed for both patients’ group with higher modularity for CM. SVR revealed that network measures could robustly predict clinical parameters for migraineurs.ConclusionWe found global network disruption for EM and CM indicated by highly segregated network in migraine patients compared to HC. Higher modularity but lower clustering coefficient in CM is suggestive of more segregation in this group compared to EM. The presence of a segregated network could be a sign of maladaptive reorganization of headache related brain circuits, leading to migraine attacks or secondary alterations to pain.
Clinical analysis of tracheobronchial foreign body aspiration in children: a focus on external and intrinsic factors
Authors: Gan Weigang , Xiao Ning , Feng Yiyuan , Zhou Danmei , Hu Juanjuan , Liu Shixi , Zou Jian 
Published: March 2021

Abstract
Background
Tracheobronchial foreign body aspiration (TFBA) is a critical disease in children and is extremely dangerous, even life-threatening. The factors affecting the occurrence and prognosis of TFBA are complex. The purpose of this study is to examine the external and intrinsic factors affecting clinical features of TFBA in West China and propose potential effective intervention measures.

Methods
We retrospectively analyzed the clinical data of pediatric patients diagnosed with TFBA with foreign bodies (FBs) removed by rigid bronchoscopy under general anesthesia at the otolaryngology department from December 2017 to November 2018. The data included age, sex, clinical symptoms, type and location of FB, guardians, prehospital duration and residence of these pediatric patients.

Results
The ratio of males (72) to females (53) was 1.4:1. Children aged from 1 to 3 years accounted for 76% (95/125) of patients. Cough, continuous fever and dyspnea were the primary symptoms. The right primary bronchus was the most common location of FB detection by rigid bronchoscopy (67 cases, 53.6%). Organic FBs were most common in our study. Guardians of patients significantly differed in the rural (parents 16, grandparents 31) and urban (parents 52, grandparents 26) groups (χ2 = 12.583, p = 0.000). More children in the rural group than in the urban group had a treatment delay longer than 72 h. More children in the group with no history of FB aspiration (12, 25%) than in the group with prior FB aspiration had a treatment delay longer than 72 h.

Conclusion
Pediatric TFBA is a common emergency in otolaryngology. Age, sex, tracheobronchial anatomy and other physiological elements were defined as intrinsic factors, while guardians, residence, FB species and prehospital time were defined as external factors of TFBA. External and intrinsic factors both influence the occurrence and progression of TFBA. It is extremely important to take effective measures to control external factors, which can decrease morbidity and mortality.
Theranostic SPECT reconstruction for improved resolution: application to radionuclide therapy dosimetry
Authors: Marquis H. , Deidda D. , Gillman A. , Willowson K. P. , Gholami Y. , Hioki T. , Eslick E. , Thielemans K. , Bailey D. L. 
Published: March 2021

Abstract
Background
SPECT-derived dose estimates in tissues of diameter less than 3× system resolution are subject to significant losses due to the limited spatial resolution of the gamma camera. Incorporating resolution modelling (RM) into the SPECT reconstruction has been proposed as a possible solution; however, the images produced are prone to noise amplification and Gibbs artefacts. We propose a novel approach to SPECT reconstruction in a theranostic setting, which we term SPECTRE (single photon emission computed theranostic reconstruction); using a diagnostic PET image, with its superior resolution, to guide the SPECT reconstruction of the therapeutic equivalent. This report demonstrates a proof in principle of this approach.

Methods
We have employed the hybrid kernelised expectation maximisation (HKEM) algorithm implemented in STIR, with the aim of producing SPECT images with PET-equivalent resolution. We demonstrate its application in both a dual 68Ga/177Lu IEC phantom study and a clinical example using 64Cu/67Cu.

Results
SPECTRE is shown to produce images comparable in accuracy and recovery to PET with minimal introduction of artefacts and amplification of noise.

Conclusion
The SPECTRE approach to image reconstruction shows improved quantitative accuracy with a reduction in noise amplification. SPECTRE shows great promise as a method of improving SPECT radioactivity concentrations, directly leading to more accurate dosimetry estimates in small structures and target lesions. Further investigation and optimisation of the algorithm parameters is needed before this reconstruction method can be utilised in a clinical setting.
Impact of Robinia pseudoacacia stand conversion on soil properties and bacterial community composition in Mount Tai, China
Authors: Li Kun , Han Xu , Ni Ruiqiang , Shi Ge , de-Miguel Sergio , Li Chuanrong , Shen Weixing , Zhang Yikun , Zhang Xingzhong 
Published: March 2021

Abstract
Background
Robinia pseudoacacia is a widely planted pioneer tree species in reforestations on barren mountains in northern China. Because of its nitrogen-fixing ability, it can play a positive role in soil and forest restoration. After clear-cutting of planted stands, R. pseudoacacia stands become coppice plantations. The impacts of shifting from seedling to coppice stands on soil bacterial community and soil properties have not been well described. This study aims to quantify how soil properties and bacterial community composition vary between planted seedling versus coppice stands.

Methods
Nine 20 m × 20 m plots were randomly selected in seedling and coppice stands. The bulk soil and rhizosphere soil were sampled in summer 2017. Bulk soil was sampled at 10 cm from the soil surface using a soil auger. Rhizosphere soil samples were collected using a brush. The soil samples were transported to the laboratory for chemical analysis, and bacterial community composition and diversity was obtained through DNA extraction, 16S rRNA gene amplification and high-throughput sequencing.

Results
The results showed that, compared to seedling plantations, soil quality decreased significantly in coppice stands, but without affecting soil exchangeable Mg2+ and K+. Total carbon (C) and nitrogen (N) were lower in the rhizosphere than in bulk soil, whereas nutrient availability showed an opposite trend. The conversion from seedling to coppice plantations was also related to significant differences in soil bacterial community structure and to the reduction of soil bacterial α-diversity. Principal component analysis (PCA) showed that bacterial community composition was similar in both bulk and rhizosphere soils in second-generation coppice plantations. Specially, the conversion from seedling to coppice stands increased the relative abundance of Proteobacteria and Rhizobium, but reduced that of Actinobacteria, which may result in a decline of soil nutrient availability. Mantel tests revealed that C, N, soil organic matter (SOM), nitrate nitrogen (NO3−-N) and available phosphorus positively correlated with bacterial community composition, while a variation partition analysis (VPA) showed that NO3−-N explained a relatively greater proportion of bacterial distribution (15.12%), compared with C and SOM. Surprisingly, N showed no relationship with bacterial community composition, which may be related to nitrogen transportation.

Conclusions
The conversion from seedling to coppice stands reduced soil quality and led to spatial-temporal homogenization of the soil bacterial community structure in both the rhizosphere and bulk soils. Such imbalance in microbial structure can accelerate the decline of R. pseudoacacia. This may affect the role of R. pseudoacacia coppice stands in soil and forest restoration of barren lands in mountain areas.