bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of Allied Health Clinical Supervision Following the Implementation of an Organisational Framework
Authors: Gardner Marcus , McKinstry Carol , Perrin Byron 
Published: September 2021

Abstract
Background: Clinical supervision makes an important contribution to high quality patient care and professional wellbeing for the allied health workforce. However, there is limited research examining the longitudinal implementation of clinical supervision for allied health. The aim of this study was to determine the effectiveness of clinical supervision for allied health at a regional health service and clinicians’ perceptions of the implementation of an organisational clinical supervision framework.Methods: A cross-sectional study was conducted as a phase of an overarching participatory action research study. The MCSS-26 tool was used to measure clinical supervision effectiveness with additional open-ended questions included to explore the implementation of the clinical supervision framework. MCSS-26 findings were compared with an initial administration of the MCSS-26 5 years earlier. MCSS-26 data (total scores, summed domain and sub-scale scores) were analysed descriptively and reported as mean and standard deviation values. Differences between groups were analysed with independent-samples t-test (t) and one-way between groups ANOVA.Results: There were 125 responses to the survey (response rate 50%). The total MCSS-26 score was 78.5 (S.D. 14.5). The total MCSS-26 score was unchanged compared with the initial administration. There was a statistically significant difference in clinical supervision effectiveness between speech pathology and physiotherapy (F = 2.9, p = 0.03) and higher MCSS-26 scores for participants whose clinical supervisor was a senior clinician and those who chose their clinical supervisor. Seventy percent of participants perceived that the organisation’s clinical supervision framework was useful and provided structure and consistent expectations for clinical supervision.Conclusions: Clinical supervision was effective for allied health in this regional setting and clinical supervision effectiveness was maintained over a 5 year period. The implementation of an organisational clinical supervision framework may have positively impacted on the effectiveness of clinical supervision for some professions.
Scheduling Based Decision Support System Design for Determining the Number of Setup Workers Under SMED Environment
Authors: Civan Hatice Nida , Cevikcan Emre 
Published: September 2021

Abstract
In industrial manufacturing systems, high profit achievement aim considers financial performance under the use of scarce resources and limiting wastes require a systematic approach lean method. Inventory cost, idle time cost, material cost, rework cost rise with large-lot production and work pieces. Achieving economic lot requires setup activity effect. Setup activity effect consists of setup activity time. Setup activity time is production time of previous setup activity exact product to successive setup activity exact product. Manufacturing difficulties of many enterprises push them to demand lean manufacturing tools and develop new ways. Cellular manufacturing, Value stream mapping (VSM), Total productive maintenance (TPM) and Single minute exchange of dies (SMED) are vital lean manufacturing tools to separate Non-value added activities (NVA) and Value added activities (VA), and eliminate wastes. Many studies examined the first four lean manufacturing tool. In this study, scheduling of set-up tasks on SMED environment proposes to examine lead time reduction, lean production method and scheduling setup tasks of setup activity. Continuous improvement encourages setup workers and operators to involve frequent improvement. In the case of yarn processing, setup activity and setup task of machine assigned for jobs to reduce raw material and processing time waste.
Genetic Similarity Between Donor And Recurrent Parents Can Reduce The Number of Backcross Generation In Marker-Assisted Backcross
Authors: de Souza Elton Otacílio , Môro Gustavo Vitti , Rodrigues Gabriel Belfort , Schuster Ivan 
Published: September 2021

Abstract
The marker assisted backcross (MABC) method is the most used to obtain transgenic hybrid and transgenic inbred lines in maize with few backcrosses (BC) generations. It is possible that the use of donor parents with greater genetic similarity with recurrent parents can further reduce the number of BC generation to recover recurrent parent genome. The objective of this study was to evaluate the influence of genetic distance between parents and the percentage of recurrent parent genome recovery, as well as the similarity of BC plants and recurrent parent. Nine maize BC populations were evaluated, with genetic distances between donors and recurrent parents ranging from 0.238 to 0.499. In the backcross generations, molecular markers were used to identify the plants with the highest percentage of recurrent genome recovery and with greater similarity to the recurrent parent. There was no difference in the recurrent genome recovery among populations after three BC generations. In the first two BC generation the similarity between BC plants and recurrent parents was positively correlated with the similarity between donor and the populations recurrent parent. BC populations with higher similarity among parents could be finished with two BC generations, and BC populations with lower similarity could just be finished after three generation of MABC. The use of donor parents with higher similarity with recurrent parent can reduce one BC generation in MABC approach.
Electric Properties of AlGaN/GaN/Si High Electron Mobility Transistors
Authors: Mosbahi H. , GASSOUMI Malek , Bchetnia A. , Zaidi M.A. 
Published: September 2021

Abstract
This work investigated the electrical properties in AlGaN/GaN/Si HEMTsgrown by molecular beam epitaxy. The electrical behavior have been investigated using by electric permittivity, modulus formalism and conductance measurements. As has been found from electrical conductance, dispersive behavior is related to barrier inhomogeneity and deep trap in barrier layer. On the other hand, the strain relaxation of charge transport is studied both permittivity and electric modulus formalisms.
Talaromyces Marneffei Mp1p Antigen Detection May Play an Important Role in the Early Diagnosis of Talaromycosis in Patients with Acquired Immunodeficiency Syndrome
Authors: Chen Xiaoman , Ou Xu , Wang Haodi , Li Liya , Guo Pengle , Chen Xiejie , Cai Weiping , Tang Xiaoping , Li Linghua 
Published: September 2021

Abstract
Talaromycosis is a life-threatening fungal disease commonly seen in patients with acquired immunodeficiency syndrome (AIDS), which is endemic in Southern China and Southeast countries. The diagnostic methods available for talaromycosis are relatively time-consuming and yield a high mortality. Therefore, early diagnosis of talaromycosis is extremely important. We aimed to determine a potential method for assisting in its early diagnosis. A total of 283 patients with AIDS admitted to our hospital because of opportunistic infections were prospectively included in this case-control study and divided into those with (TSM, n = 93) and without talaromycosis (non-TSM, n = 198). The diagnostic accuracy of the Mp1p assay with enzyme immunoassay, galactomannan (GM) assay, and blood culture performed within 3 days of hospitalisation was evaluated. Most patients were men (n = 243 [85.9%]), mainly young (52.3%), and middle-aged adults (33.9%). The positivity rates in the Mp1p assay, GM assay, and blood culture were 72%, 64.5%, and 81.7%, respectively, in the TSM group. The sensitivity, specificity, and positive and negative predictive values of the Mp1p assay were 72.0% (67/93), 96.8% (184/190), 91.8% (67/73), and 87.6% (184/210), respectively. The Mp1p assay showed a substantial agreement with the gold standard (kappa: 0.729) and superiority to the GM assay (kappa: 0.603); it also showed a superior diagnostic efficacy in the patients with CD4 + T cell counts of < 50 Nr/µL compared to those with CD4 + T cell counts of ≥ 50 Nr/µL. The Mp1p assay possesses a superior advantage in assisting in the early diagnosis of talaromycosis in patients with AIDS, especially those with low CD4 + T cell counts.
Comparative Study of Outcomes by Surgical Procedures and Monocular Elevation Deficiency Syndrome in Indian Population
Authors: Shah Shreya , Shah Mehul A , Makhloga Sakshi , Korane Ashvini , Dadia Nirav , Sanghani Meera 
Published: September 2021

Abstract
Introduction: Monocular elevation deficiency syndrome (MEDS) is a monocular elevation deficiency in abduction and adduction characterised by the hypofunction of superior rectus (SR) and inferior oblique muscles. Only a limited number of studies are published on the management of this problem. Herein, the indications and types of surgery for monocular elevation deficiency syndrome are reported.Methods: In this retrospective cohort study, all MEDS patients reported during 2010 to 2020 were retrieved from Electronic Medical Records after approval from the Hospital Ethical Committees. The data were exported in a pre-tested online format. The demographic and clinical information and data of surgeries, including strabismus and ptosis, were reported. The follow-up data were collected in a specific format. Strabismus was managed using Knapp procedure, Inferior Rectus recession and a combination of both approaches. Ptosis was corrected by Levator Palpebral Superioris (LPS) resection and brow suspension. The data were analysed using SPSS 22 based on descriptive analysis and cross-tabulation.Results: The cohort consists of 62 cases (females 26, males 36) of patients with mean age 17.00±12.31 years 40/62 cases comprised the paediatric age group. Knapp was carried out in 39, IR recession was carried out in 35, and combined Knapp+IR recession was performed in 17 cases based on FDT and FGT data. The comparative study found significant difference amongst these techniques (P=0.04). Ptosis correction was carried out by LPS resection in 21 and brow suspension in 23 cases depending on LPS function. This comparative study did not find any significant difference in the results (P=0.234).Conclusion: MEDS is a rare disease with various clinical features. The surgical management of strabismus may have more success for the combined technique than for those applied alone.
Anthropometric and Body Composition Differences Among Genotype Controlled Indigenous Adult Kiwcha Natives Living at Low (230 M) and High Altitude (3,800 M) in Ecuador
Authors: Ortiz-Prado Esteban , Mendieta Gonzalo , Simbaña-Rivera Katherine , Gomez-Barreno Lenin , Landazuri Samanta , Vasconez Eduardo , Calvopiña Manuel , Viscor Ginés 
Published: September 2021

Abstract
Background: Anthropometric measures have been classically used to understand the impact of environmental factors on the living conditions of individuals and populations. Most reference studies on development and growth in which anthropometric measures were used were carried out in populations that are located at sea level but there are few studies carried out in high altitude populationsObjective: The objective of this study is to evaluate anthropometric and body composition in autochthonous Kiwchas permanently living at low and high-altitude.Methodology: A cross-sectional study of anthropometric and body composition between genetically matched lowland Kiwchas from Limoncocha (230 m) at Amazonian basin and high-altitude Kiwchas from Oyacachi (3,180 m) in Andean highlands. Student’s t-test was used to analyze differences between continue variables and Chi square test was performed to check the association or independence of categorical variables. Fisher´s exact test or Spearman test were used when the variable had evident asymmetries with histograms prior to the selection of the test. Results: Our study shows that low altitude women are shorter and heavier, but these differences are not statistically significant (p value 0.333) on the other hand high altitude men are shorter than their counterparts who live at low altitude with a p value 0.019. In relation to body muscle %, women at high altitudes have less body muscle % (-24.8%) while men at high altitudes have significantly more muscle body mass % (+ 13.5%) than their lowland counterpart. Body fat % is lower among low altitude women (-15.5%) and no differences were found among men.Conclusions: This is the first study to be performed in two genotyped controlled matching populations located at different altitudes. The anthropometric differences vary according to sex, demonstrating that high altitude population are in general lighter and shorter than their low altitude controls. Men at high altitude have more muscled bodies than their lowland counterpart but their body age was older than their real age.
HOXA3-Induced Exosomal lncRNA RNF144A-AS1 Promotes Liver Metastasis of Gastric Cancer via Interacting with PUF60 Protein and Sponging miR-361-3p
Authors: He Rong , Zhang Heng , He Lian , Huang Jiabin , Dai Zhe , Xiang Shouyan , Zhou Yongjing , Lang Yakun , Gong Dandan , Fan Yu 
Published: September 2021

Abstract
Background: Long non-coding RNA (lncRNA) plays an important regulatory role in the development and progression of gastric cancer(GC). However, the biological role and potential molecular mechanism of lncRNA RNF144A-AS1 in liver metastasis of gastric cancer(GCLM) remain unclear. Methods: LncRNAs associated with GCLM were identified by microarray. Gain or loss of function approaches was used to investigate the biological functions of RNF144A-AS1. The expression of RNF144A-AS1 was detected by real-time quantitative PCR, and the molecular mechanism of RNF144A-AS1 was investigated by RNA pull-down assay, Western blot, luciferase activity, RNA immunoprecipitation. Finally, nude mouse models and bioluminescence imaging were used to verify the role of RNF144A-AS1 in GCLM in vivo. Results:We identified that RNF144A-AS1 was highly expressed in GC by microarray.RNF144A-AS1 was related to GCLM,and poor DFS and OS. The expression of RNF144A-AS1 in serum exosomes of GC patients was significantly increased, while the level of RNF144A-AS1 was significantly decreased after GC resection. Overexpression of RNF144A-AS1 in exosomes can promote the growth and invasion of co-cultured GC cells in vitro. The down-regulation of RNF144A-AS1 induced the proliferation, migration, and invasion of GC cells in vitro and in vivo. Mechanistically, the transcription factor HOXA3 bound to the promoter region of RNF144A-AS1 could activate RNF144A-AS1, and RNF144A-AS1 promotes GCLM via interacting with PUF60 protein and sponging miR-361-3p.Conclusions: The present study indicated that exosome RNF144A-AS1 overexpression contributes to GCLM and would be a promising biomarker for the diagnosis and prognosis of GCLM.
Experience of Living and Coping with Spinal Cord Disability due to Road Traffic Injuries: A Phenomenological Study Running title: Living and Coping with Spinal Cord Disability
Authors: Hashemiparast Mina , Sheydaei Hajieh , Gharacheh Maryam , Chattu Vijay Kumar 
Published: September 2021

Abstract
Background: Globally, people living with spinal cord disability experience more limitations in an individual and social life. In many cases, this leads to complex psychological and social problems that may also affect the adaptation to the conditions. The aim of the study was to explore the experience of living and coping with disability in people with spinal cord disability due to road traffic accidents in Iran's cultural context.Methods: This is a qualitative study with a phenomenological approach on ten Iranian people with spinal cord disability due to road traffic injuries. Data collection and analysis were performed from September to March 2019. Data were collected by individual, face-to-face in-depth interviews, and the experience of living with disability and adaptation strategies were explored. Van Manen’s methodical activities were used to guide the study's process.Results: ‘victim of destiny’ was the main theme extracted from three themes and nine sub-themes. The disabled people viewed life as a prison that destiny had ordained for them and trapped them in the fences of isolation, anger, regret, anxiety, sorrow, pity, and futility such that they require assistance from others as dependent individuals. Religious recourse, satisfaction with God's expediency, and change of life values were the participants' coping strategies to adjust to their difficulties.Conclusions: The study clarified the permanent constraints, needs, barriers and adaptation strategies of disabled people.
Effect of Estradiol as a Continuous Variable on Breast Cancer Survival by Menopausal Status: A Cohort Study in China
Authors: Li Junxian , Li Chenyang , Feng Ziwei , Liu Luyang , Zhang Liwen , Kang Wenjuan , Liu Ya , Ma Baoshan , Li Haixin , Huang Yubei , Zheng Hong , Song Fangfang , Song Fengju , Chen Kexin 
Published: September 2021

Abstract
BackgroundHigh levels of circulating estradiol (E2) are associated with increased risk of breast cancer, whereas its relationship with breast cancer prognosis is still unclear. We studied the effect of E2 concentration on breast cancer survival among pre- menopausal and post- menopausal patients in China.MethodsWe evaluated this association among 8766 breast cancer cases diagnosed between 2005 and 2017 from the Tianjin Breast Cancer Cases Cohort. Levels of serum E2 were measured in pre-menopausal and post-menopausal women. Multivariable-adjusted Cox proportional hazards models were used to estimate hazard ratios (HR) and 95% confidence intervals (95% CI) between quartile of E2 levels and overall survival (OS) and progression-free survival (PFS) of breast cancer. The penalized spline was then used to test for non-linear relationships between E2 (continuous variable) and survival endpoints.ResultsA total of 612 deaths and 982 progressions occurred over follow-up through 2017. Compared to women in the quartile 3, the highest quartile of E2 was associated with reduced risk of both PFS in pre-menopausal women (HR=1.79, 95% CI: 1.17-2.75, P=0.008) and OS in post-menopausal women (HR=1.35, 95% CI: 1.04-1.74, P=0.023). OS and PFS in pre-menopausal women exhibited a nonlinear relation (“L-shaped” and “U-shaped”, respectively) with E2 levels. However, there was a linear relationship in post-menopausal women, among whom increasing E2 was associated with escalating risks of death and progression. Moreover, patients with estrogen receptor-negative (ER-negative) breast cancer showed a “U-shaped” relationship with OS and PFS in pre-menopausal women.ConclusionsPre-menopausal breast cancer patients have a plateau stage of prognosis at the intermediate concentrations of E2, whereas post-menopausal patients have no apparent threshold, and ER status may have an impact on this relationship.
Effects of Recombinant Human Brain Natriuretic Peptide in Patients of Chronic Thromboembolic Pulmonary Hypertension with Chronic Kidney Disease Who Underwent Balloon Pulmonary Angioplasty
Authors: Zhang Yu , Zhang Yongxiang , Liao Chang , Wang Xiaoxu 
Published: September 2021

Abstract
BackgroundChronic thromboembolic pulmonary hypertension (CTEPH) leads to impairment of pulmonary hemodynamics, triggers secondary right heart dysfunction, regularly accompanied by systemic malperfusion, and subsequently alter glomerular filtration rates (GFR). Chronic kidney disease (CKD) may also adversely affect CTEPH prognosis. This study aimed to assess how Brain natriuretic peptide (BNP) combined with balloon pulmonary angioplasty (BPA) improve right heart hemodynamics and estimated GFR (eGFR) of CKD in CTEPH patients.MethodsWe retrospectively studied 47 patients with confirmed CTEPH with CKD who were treated with BPA and admitted to the intensive care unit between December 2012 and September 2020. The patient was divided into two groups based on whether to receive recombinant human brain natriuretic peptide treatment (rhBNP). The information of patients between two groups was systematically compared in hospital and follow up. eGFR were assessed at several time points. ResultsFor rhBNP group, eGFR was significantly higher in the two periods of Prior to last BPA and 6-month follow-up. A significantly higher Δ eGFR from baseline to follow-up was observed. There was significant difference on levels of troponin I, NT-proBNP, and right ventricle diameter at follow-up. Conclusion﻿rhBNP combined BPA therapy improves pulmonary and systemic hemodynamics, with positive effects on renal function, which maybe an alternative treatment option for improving clinical outcomes.
Constant-roll inflation in the generalized SU(2) Proca theory
Authors: Aguirre Juan Garnica , Diaz Luis Gomez , Leon Andres Navarro , Garcia Yeinzon Rodriguez 
Published: September 2021

Abstract
The generalized SU(2) Proca theory (GSU2P for short) is a variant of the well known generalized Proca theory (GP for short) where the vector field belongs to the Lie algebra of the SU(2) group of global transformations under which the action is made invariant. New interesting possibilities arise in this framework because of the existence of new interactions of purely non-Abelian character and new configurations of the vector field that result in spatial spherical symmetry and the cosmological dynamics being driven by the propagating degrees of freedom. We study the two-dimensional phase space of the system that results when the cosmic triad configuration is employed in the Friedmann-Lemaitre-Robertson-Walker background and find an attractor curve whose attraction basin covers almost all the allowed region. Such an attractor curve corresponds to a primordial inflationary solution that has the following characteristic properties: 1.) it is a de Sitter solution whose Hubble parameter is regulated by a generalized version of the SU(2) group coupling constant, 2.) it is constant-roll including, as opposite limiting cases, the slow-roll and ultra slow-roll varieties, 3.) a number of e-folds $N > 60$ is easily reached, 4.) it has a graceful exit into a radiation dominated period powered by the canonical kinetic term of the vector field and the Einstein-Hilbert term. The free parameters of the action are chosen such that the tensor sector of the theory is the same as that of general relativity at least up to second-order perturbations, thereby avoiding the presence of ghost and Laplacian instabilities in the tensor sector as well as making the gravity waves propagate at light speed. This is a proof of concept of the interesting properties we could find in this scenario when the coupling constants be replaced by general coupling functions.