bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy, acceptability, and safety of antidepressants for low back pain: a systematic review and meta-analysis
Authors: Ferraro Michael C. , Bagg Matthew K. , Wewege Michael A. , Cashin Aidan G. , Leake Hayley B. , Rizzo Rodrigo R. N. , Jones Matthew D. , Gustin Sylvia M. , Day Richard , Loo Colleen K. , McAuley James H. 
Published: February 2021

Abstract
Background
Antidepressant medicines are used to manage symptoms of low back pain. The efficacy, acceptability, and safety of antidepressant medicines for low back pain (LBP) are not clear. We aimed to evaluate the efficacy, acceptability, and safety of antidepressant medicines for LBP.

Methods
We searched CENTRAL, MEDLINE, Embase, CINAHL, ClinicalTrials.gov, the EU Clinical Trials Register, and the WHO International Clinical Trial Registry Platform from inception to May 2020. We included published and trial registry reports of RCTs that allocated adult participants with LBP to receive an antidepressant medicine or a placebo medicine. Pairs of authors independently extracted data in duplicate. We extracted participant characteristics, study sample size, outcome values, and measures of variance for each outcome. We data using random-effects meta-analysis models and calculated estimates of effects and heterogeneity for each outcome. We formed judgments of confidence in the evidence in accordance with GRADE. We report our findings in accordance with the PRISMA statement. We prespecified all outcomes in a prospectively registered protocol. The primary outcomes were pain intensity and acceptability. We measured pain intensity at end-of-treatment on a 0–100 point scale and considered 10 points the minimal clinically important difference. We defined acceptability as the odds of stopping treatment for any reason.

Results
We included 23 RCTs in this review. Data were available for pain in 17 trials and acceptability in 14 trials. Treatment with antidepressants decreased pain intensity by 4.33 points (95% CI − 6.15 to − 2.50) on a 0–100 scale, compared to placebo. Treatment with antidepressants increased the odds of stopping treatment for any reason (OR 1.27 [95% CI 1.03 to 1.56]), compared to placebo.

Conclusions
Treatment of LBP with antidepressants is associated with small reductions in pain intensity and increased odds of stopping treatment for any reason, compared to placebo. The effect on pain is not clinically important. The effect on acceptability warrants consideration. These findings provide Level I evidence to guide clinicians in their use of antidepressants to treat LBP.

Trial registration
We prospectively registered the protocol for this systematic review on PROSPERO (CRD42020149275).
Post-rape medicolegal service provision and policy in East Africa: a scoping review protocol
Authors: Rockowitz Sarah , Flowe Heather , Bradbury-Jones Caroline 
Published: February 2021

Abstract
Background
Sexual and gender-based violence (SGBV) is an epidemic that continues to affect both men and women in East Africa. Despite the high prevalence of SGBV in this region, sexual offense policies are often unclear, poorly enforced, or completely lacking. When policies do exist practitioners who assist survivors in the aftermath of the violation often are unaware of them, or may not implement them for a host of reasons (e.g., culture, personal beliefs, and resource limitations). This scoping review seeks to evaluate the literature on existing sexual offense policies in East Africa and understand the consequences of its implementation, or lack thereof, on a survivor’s justice and medical and psychological wellbeing.

Methods
This scoping review will be guided by the amended Arksey and O’Malley framework recommendations (Levac et al., Implementation Science. 2010) and the 2015 Joanna Briggs Institute guidelines (Peters et al., Joanna Briggs Institute Reviewer’s Manual, 2020). The results will be presented using the adapted Preferred Reporting Items for Systematic Reviews and Meta-Analysis: Extension for Scoping Reviews chart (PRISMA-ScR). The search strategy for this scoping review will include entering search terms into electronic databases, including PubMed, SCOPUS, CINAHL Plus, The British Library, and Web of Science. A “cited by” search will be conducted, which will also include entering references from the reference lists from other articles. Grey literature will be included in the review, which will be identified through searching individual country’s government websites, and other websites, such as the World Health Organization and the United Nations Human Rights Council. All references will be exported to Endnote library. Two independent reviewers will screen titles, abstracts, and full articles. Thematic analysis will be used to evaluate the included articles.

Discussion
Understanding the legal and regulatory context of SGBV in East Africa and its associations with service provision will generate knowledge on implications for wellbeing. This information can be used to evaluate potential human rights violations and inform future policy.

Systematic review registration
Open Science Framework https://osf.io/vh3gm
Soil quality evaluation under different land use types in Kersa sub-watershed, eastern Ethiopia
Authors: Mulat Yared , Kibret Kibebew , Bedadi Bobe , Mohammed Muktar 
Published: February 2021

Abstract
Background
Soil quality, which can be inferred using indicators that interact synergistically, is affected by land use types and agricultural management practices. This study assessed the status of soil quality under three adjacent land uses (cultivated, grazing, and fallow) in Kersa subwatershed (622 ha). Soil samples were collected from the surface soil (0–20 cm depth) of the identified land uses with three replications and the soil quality parameters were analyzed. A minimum data set of soil quality indicators were selected from physical, chemical, and biological parameters using the literature review and expert opinion method. Linear scoring functions were used to give the unitless scores for the selected data sets, which were then integrated into a soil quality index (SQI).

Results
The results revealed that bulk density, aggregate stability, pH, cation exchange capacity (CEC), available P, and soil organic carbon (SOC) had a significant difference in SQI among the different land uses. The soil quality indices were 0.69 for grazing land, 0.62 for cultivated land, and 0.59 for the fallow land. The SQI of all the land uses falls in the intermediate soil quality (0.55 < SQI < 0.70) class.

Conclusion
In almost all the quality indicators assessed, the grazing land was superior to the cultivated and fallow lands. Therefore, implementing management practices that enhance soil quality like organic matter-controlled systems is imperative for sustainable agricultural production in the study area.
Molecular causes of congenital anomalies of the kidney and urinary tract (CAKUT)
Authors: Kohl Stefan , Habbig Sandra , Weber Lutz T. , Liebau Max C. 
Published: February 2021

AbstractCongenital anomalies of the kidney and urinary tract (CAKUT) occur in 0.5–1/100 newborns and as a group they represent the most frequent cause for chronic kidney failure in children. CAKUT comprise clinically heterogeneous conditions, ranging from mild vesicoureteral reflux to kidney aplasia. Most forms of CAKUT share the pathophysiology of an impaired developmental interaction of the ureteric bud (UB) and the metanephric mesenchyme (MM). In most cases, CAKUT present as an isolated condition. They also may occur as a component in rare multi-organ syndromes. Many CAKUT probably have a multifactorial etiology. However, up to 20% of human patients and > 200 transgenic mouse models have a monogenic form of CAKUT, which has fueled our efforts to unravel molecular kidney (mal-)development. To date, genetic variants in more than 50 genes have been associated with (isolated) CAKUT in humans. In this short review, we will summarize typical imaging findings in patients with CAKUT and highlight recent mechanistic insight in the molecular pathogenesis of monogenic forms of CAKUT.
A cationic quantum dot-based ratiometric fluorescent probe to visually detect berberine hydrochloride in human blood serums
Authors: Liu Mingyang , Du Xuejun , Xu Ke , Yan Binwei , Fan Zaibi , Gao Zideng , Ren Xueqin 
Published: February 2021

AbstractBerberine hydrochloride (BH) is an isoquinoline alkaloid normally used as drug to treat diseases. Compared with the traditional detection methods, the carbon quantum dots (CQDs) have better selectivity, high sensitivity, easy operation, and is inexpensive which could be widely utilized as fluorescent nanoprobes to detect various compounds quantificationally. And ratiometric fluorescent sensors conspicuously increase sensitivity and precision detection and improve quantification. In this work, we use water-soluble and fluorescent cationic carbon dots cetylpyridinium chloride monohydrate (CPC)-CQDs to connect with pinacyanol chloride (PC) and sodium tetraphenylborate (ST) as the ratiometric fluorescent probe to detect BH. The ratiometric fluorescent probe has high sensitivity towards alkaloids and metal ions, photochemical stability (60 min), and pH stability (from 6.0 to 8.0), with the detection range from 0 to 200 μM, and limit was as low as 57.35 nM. The accuracy of the method was verified by spiked recovery experiment in different human blood serums which were drawn from healthy adult volunteers to explore the practicability. The recoveries were in the range 94.34 to 105.48% with relative standard deviations (RSD) of 0.80 to 2.92%. In addition, we could observe that the fluorescence was gradually darkened, and the color turned yellow to realize the visual detection. It is expected that this work would open up a new strategy for detecting BH in the environment and human blood serums.
Dimerization of cell-penetrating buforin II enhances antimicrobial properties
Authors: Lee Hyunhee , Yang Sungtae 
Published: February 2021

AbstractAntimicrobial peptides (AMPs) that selectively permeabilize bacterial membranes are promising alternatives to conventional antibiotics. Dimerization of AMP is considered an attractive strategy to enhance antimicrobial and membrane-lytic activity, but it also increases undesired hemolytic and cytotoxic activity. Here, we prepared Lys-linked homodimers of membrane-permeabilizing magainin II and cell-penetrating buforin II. Dimerization did not significantly alter conformational behavior, but it had a substantial impact on antimicrobial properties. We found that while the magainin II dimer showed increased antimicrobial and cytotoxic effects, the buforin II dimer conferred much greater antibacterial potency without exhibiting cytotoxic activity. Interestingly, the buforin II dimer was highly effective against several antibiotic-resistant bacterial isolates. Membrane permeabilization experiments indicated that the magainin II dimer rapidly disrupted both anionic and zwitterionic membranes, whereas the buforin II dimer selectively disrupted anionic membranes. Like the monomeric form, the buforin II dimer was efficiently translocated across lipid bilayers. Therefore, our results suggest that the dimerization of cell-penetrating buforin II not only disrupts the bacterial membrane, but also translocates it across the membrane to target intracellular components, resulting in effective antimicrobial activity. We propose that dimerization of intracellular targeting AMPs may present a superior strategy for therapeutic control of pathogenic bacteria.
Intrathecal chloroprocaine or hyperbaric prilocaine for ambulatory knee surgery? A prospective randomized study
Authors: Guntz E , Vasseur C , Ifrim D , Louvard A , Fils J F , Kapessidou Y 
Published: February 2021

Abstract
Purpose
The aim of this study was to compare intrathecal 1% chloroprocaine with 2% hyperbaric prilocaine in the setting of ambulatory knee arthroscopy. We hypothesized that complete resolution of the sensory block was faster with chloroprocaine.

Methods
Eighty patients scheduled for knee arthroscopy were included in this prospective randomized double-blind study. Spinal anesthesia was performed with either chloroprocaine (50 mg) or hyperbaric prilocaine (50 mg). Characteristics of sensory and motor blocks and side effects were recorded.

Results
Mean time to full sensory block recovery was shorter with chloroprocaine (169 (56.1) min vs 248 (59.4)). The characteristics of the sensory blocks were similar at the T12 dermatome level between the two groups. Differences appeared at T10: the percentage of patients with a sensory block was higher, onset quicker and duration longer with hyperbaric prilocaine. The number of patients with a sensory block at T4 dermatome level in both groups was minimal. Times to full motor recovery were identical in both groups (85 (70–99) vs 86 (76–111) min). Time to spontaneous voiding was shorter with chloroprocaine (203 (57.6) min vs 287.3 (47.2) min). Incidence of side effects was low in both groups.

Conclusions
When considering the characteristics of the sensory block, the use of chloroprocaine may allow an earlier discharge of patients. Cephalic extension was to a higher dermatomal level and the sensory block at T10 level was of prolonged duration with hyperbaric prilocaine, suggesting that the choice between the two drugs should also be performed based on the level of the sensory block requested by the surgery.
This study is registered in the US National Clinical Trials Registry, registration number: NCT030389, the first of February 2017, Retrospectively registered.
Health monitoring of finishing pigs by secondary data use – a longitudinal analysis
Authors: Grosse-Kleimann Julia , Plate Heiko , Meyer Henning , Gerhardy Hubert , Heucke Corinna Elisabeth , Kreienbrock Lothar 
Published: February 2021

AbstractBackgroundIn Germany, animal welfare has become an increasingly important issue. Since 2006, German legislation demands self-monitoring of animal welfare by farmers, but there is a lack of prescribed indicators for governmental monitoring. Since recording of the health status through examinations on individual farms requires many resources, secondary data use is obvious. Therefore, this study deals with the overall evaluation and utilization of existing production data from the German pork production. Performance data and information on antibiotic usage and meat inspection were used for a benchmarking system of animal health in finishing pigs.ResultsSeven health scores and one total score were evaluated for 184 finishing pig herds on semi-annual basis between July 2017 and June 2019, based on the health indicators mortality, average daily gain, feed conversion ratio, treatment frequency, respiratory lesions, exterior lesions and animal management. In preparation, the selected health indicators were brought to the same scale and skewed data were transformed to build scores (MOR, ADG, FCR, TF, RESP, EXT and MANG). A differentiated analysis was carried out for three classes of initial body weight regarding to farmers’ fattening management strategies.ConclusionsThe present study shows that existing production data of German finishing pigs are usable for welfare monitoring. However, preparatory editing steps are crucial. The total score can only be an estimate of health status because partly bad or good performance could be disguised. It has also been demonstrated, that relative benchmarking is suitable for depicting temporary fluctuations in the investigated collective.
COVID-19 and instability of stock market performance: evidence from the U.S.
Authors: Hong Hui , Bian Zhicun , Lee Chien-Chiang 
Published: February 2021

AbstractThe effect of COVID-19 on stock market performance has important implications for both financial theory and practice. This paper examines the relationship between COVID-19 and the instability of both stock return predictability and price volatility in the U.S over the period January 1st, 2019 to June 30th, 2020 by using the methodologies of Bai and Perron (Econometrica 66:47–78, 1998.10.2307/2998540; J Appl Econo 18:1–22, 2003.10.1002/jae.659), Elliot and Muller (Optimal testing general breaking processes in linear time series models. University of California at San Diego Economic Working Paper, 2004), and Xu (J Econ 173:126–142, 2013.10.1016/j.jeconom.2012.11.001). The results highlight a single break in return predictability and price volatility of both S&P 500 and DJIA. The timing of the break is consistent with the COVID-19 outbreak, or more specifically the stock selling-offs by the U.S. senate committee members before COVID-19 crashed the market. Furthermore, return predictability and price volatility significantly increased following the derived break. The findings suggest that the pandemic crisis was associated with market inefficiency, creating profitable opportunities for traders and speculators. Furthermore, it also induced income and wealth inequality between market participants with plenty of liquidity at hand and those short of funds.
Retrobulbar hematoma following the repair of an orbital wall fracture: a case series
Authors: Kim Jeong-Mo 
Published: February 2021

Abstract
Background
Retrobulbar hematoma is a rare complication after the repair of an orbital wall fracture, but the caution is required because the condition can cause blindness.

Case presentation
In this article, 3 cases of retrobulbar hematoma after the surgical repair of an orbital wall fracture are reported. In the first patient, the permanent loss of vision was involved, while in the second patient, the author was able to prevent loss of vision by performing immediate decompression after definite diagnosis and consulting with an ophthalmologist. In the third patient, there was no surgical treatment involved; he recovered on his own without major sequelae.

Conclusions
Retrobulbar hematoma is a very serious condition that can result in blindness. Thus, when it is recognized, every effort should be made to preserve the patient’s vision and prevent blindness.
Exploring rhizosphere and potato microbiome as potential antagonist to control blackleg and potato soft rot diseases in Morocco
Authors: Sbai Idrissi Nisrine , Ouarzane Aicha , Elouazni Latifa , Hmyene Aziz , Elantri Said , Amine Abdessamad 
Published: February 2021

Abstract
Background
Blackleg and tuber soft rot are among the most important potato diseases caused by the bacteria belonging to the genera Pectobacterium. This pathogen causes significant economic losses each year. The antagonistic activity of different bacterial cultures against this pathogen was studied.

Results
Six hundred eight bacterial cultures isolated from potato tubers and rhizosphere soils procured from different locations across Morocco were tested for their antagonistic activity against Pectobacterium carotovorum. Forty isolates, all originating from tubers, showed positive antagonistic activity during preliminary screening. Among the 40 isolates, 10 were found to have a symptom suppression superior to 90%. Of the 10 isolates, 9 showed clear zone in the agar medium (in vitro test), with differences between antagonist’s inhibition diameter. For the in vivo test, 8 isolates induced total suppression of soft rot on potato slices (in vivo test). The other 2 biocontrol strains (Amo-23 and Atd-2) were capable to minimize soft rot symptoms of up to 94.4 and 96.2%, respectively. Among the selected strains for in planta experiment, 6 strains (namely Ame-4, Atd-2, Atd-4, Ag-216, Al-51, and Ama-501) showed total reduction of disease symptoms. Biochemical and molecular tests identified 8 strains of Bacillus sp. and 2 strains of Pseudomonas sp.

Conclusions
The results of the in vivo and the greenhouse experiments indicated that the selected isolates had a greatly significant effectiveness for suppressing blackleg and soft rot symptoms. The selected isolates could, therefore, be used as a biocontrol agent against blackleg and soft rot of potato.
Implementation evaluation of staff support and wellbeing programmes at an academic health science centre during COVID-19: study protocol
Authors: Krausova Barbora , Gnanapragasam Sam Nishanth , Demetriou Len , Beck Alison , Pires-Yfantouda Renata , Docherty Mary Jane , Sevdalis Nick 
Published: February 2021

Abstract
Background
Evidence from previous pandemics as well as early evidence from COVID-19 suggests risk of adverse mental health and wellbeing outcomes for healthcare workers. In response to these concerns, healthcare systems and organisations rapidly established staff support and wellbeing programmes. While there is emerging literature related to the effectiveness of such interventions, what is less well understood and evaluated is the evidence base regarding how such programmes are implemented; what supports and hinders their implementation; and how or if they are maintained following the initial acute phase of the pandemic. This study addresses this gap by studying the implementation process of COVID-19-related staff wellbeing programmes in the three UK NHS Trusts that make up one of Europe’s largest academic health sciences centres, King’s Health Partners.

Methods
We will conduct a prospective, cross-sectional descriptive study using qualitative research methods and non-probability purposive sampling to identify a study participant group representative of the population and implementation activity of interest. We will conduct semi-structured interviews of between 30 min and 1 h. We will identify theory-driven elements in the dataset using the Consolidated Framework for Implementation Research (barriers and drivers), Exploration, Preparation, Implementation, Sustainment Framework (timeline/chronology/evolution of the implementation and different issues at different times) and Expert Recommendations for Implementing Change (implementation strategies). We will then identify indicators of these constructs within the dataset and report them, as well as their inter-relationships.

Discussion
Through this study, we hope to better understand what factors hindered and enabled the implementation of three inter-linked staff support and wellbeing programmes and how/to what extent have these programmes been sustained. We will also explore whether implementation science frameworks are applicable and beneficial in conceptualising and understanding crisis driven and rapidly implemented interventions and in what ways, if any, they need to be adjusted when used in unprecedented circumstances such as the COVID-19 pandemic.