bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evidence for the effects of decommissioning man-made structures on marine ecosystems globally: a systematic map protocol
Authors: Lemasson Anaëlle J. , Knights Antony M. , Thompson Murray , Lessin Gennadi , Beaumont Nicola , Pascoe Christine , Queirós Ana M. , McNeill Louise , Schratzberger Michaela , Somerfield Paul J. 
Published: February 2021

Abstract
Background
Numerous man-made structures (MMS) have been installed in various parts of the ocean (e.g. oil and gas structures, offshore wind installations). Many are now at, or nearing, the end of their intended life. Currently, we only have a limited understanding of decommissioning effects. In many locations, such as the North Sea, regulations restrict decommissioning options to complete removal, with little consideration of alternative management options might offer. To generate a reliable evidence-base to inform the decision-making processes pertaining to marine MMS management, we propose a wide-encompassing systematic map of published research on the ecosystem effects (including ecosystem services) of marine MMS while in place and following cessation of operations (i.e. including effects of alternative decommissioning options). This map is undertaken as part of the UKRI DREAMS project which aims to develop a system to show the relative effects of implementing different decommissioning strategies in the North Sea.

Method
For the purpose of this map, we will keep our focus global, in order to subsequently draw comparisons between marine regions. The proposed map will aim to answer the following two primary questions: 1. What published evidence exists for the effects of marine man-made structures while in place on the marine ecosystem? 2. What published evidence exists for the effects of the decommissioning of marine man-made structures on the marine ecosystem? The map will follow the Collaboration for Environmental Evidence Guidelines and Standards for Evidence Synthesis in Environmental Management. Searches will be run primarily in English in at least 13 databases and 4 websites. Returns will be screened at title/abstract level and at full-text against pre-defined criteria. Relevant meta-data will be extracted for each study included. Results will be used to build a database of evidence, which will be made freely available. This map, expected to be large, will improve our knowledge of the available evidence for the ecosystem effects of MMS in the global marine environment. It will subsequently inform the production of multiple systematic-reviews and meta-analyses.
Mapping the organizational readiness to change assessment to the Consolidated Framework for Implementation Research
Authors: Kononowech Jennifer , Hagedorn Hildi , Hall Carmen , Helfrich Christian D. , Lambert-Kerzner Anne C. , Miller Susan C. , Sales Anne E. , Damschroder Laura 
Published: February 2021

Abstract
Background
Implementation researchers recognize the influential role of organizational factors and, thus, seek to assess these factors using quantitative measurement instruments. However, researchers are hindered by instruments that measure similar constructs but rely on different nomenclature and/or definitions. The Consolidated Framework for Implementation Research (CFIR) provides a taxonomy of constructs derived from prior frameworks and empirical studies of implementation-related constructs. The CFIR includes constructs based on the original Promoting Action on Research Implementation in Health Services (PARiHS) framework which highlights the key roles of strength of evidence for a specific evidence-based intervention (EBI), favorability of organizational context for change, and capacities to facilitate implementation of the EBI. Although the CFIR is among the most frequently used implementation frameworks, it does not include quantitative measures. The Organizational Resource and Context Assessment (ORCA) is a quantitative measurement instrument that was developed based on PARiHS, assessing its three domains. Factors within these three domains are conceptually similar to constructs in the CFIR but do not match directly. The aim of this work was to map ORCA survey items to CFIR constructs to enable direct comparisons and syntheses of findings across studies using the CFIR and/or ORCA.

Methods
Two distinct, independent research teams, each used rigorous constant comparative techniques with deliberation and consensus to map individual items from the ORCA to the five domains and 39 constructs of CFIR.

Results
ORCA items were mapped primarily to three of five CFIR domains: Inner Setting, Process, and Intervention Characteristics. The two research teams agreed on 88% of mappings at the higher domain level; at the lower construct level, their mappings aligned for 62.2% of the ORCA items.

Conclusions
Mapping results reveal that the ORCA focuses measurement prominently on Inner Setting, Process, and Intervention Characteristics. This mapping guide can help improve consistency in measurement and reporting, enabling more efficient comparison and synthesis of findings that use either the ORCA instrument or the CFIR framework. The guide helps advance implementation science utilizing mixed methods by providing CFIR users with quantitative measures for selected constructs and enables ORCA users to map their findings to CFIR constructs.
Phase III Study to Evaluate Efficacy and Safety of Andecaliximab With mFOLFOX6 as First-Line Treatment in Patients With Advanced Gastric or GEJ Adenocarcinoma (GAMMA-1)
Authors: Shah Manish A. , Bodoky Gyorgy , Starodub Alexander , Cunningham David , Yip Desmond , Wainberg Zev A. , Bendell Johanna , Thai Dung , He Joyce , Bhargava Pankaj , Ajani Jaffer A. 
Published: February 2021

PURPOSE Andecaliximab (ADX) is a monoclonal antibody that inhibits matrix metalloproteinase 9, an extracellular enzyme involved in matrix remodeling, tumor growth, and metastases. A phase I and Ib study of modified oxaliplatin, leucovorin, and fluorouracil (mFOLFOX6) with ADX revealed encouraging antitumor activity in patients with gastric or gastroesophageal junction (GEJ) adenocarcinoma. MATERIALS AND METHODS This phase III, randomized, double-blinded, placebo (PBO)-controlled multicenter study investigated the efficacy and safety of mFOLFOX6 with and without ADX in patients with untreated human epidermal growth factor receptor 2–negative gastric or GEJ adenocarcinoma. Random assignment was 1:1 to mFOLFOX6 + ADX or mFOLFOX6 + PBO. ADX/PBO 800 mg was infused on days 1 and 15 of each 28-day cycle. Protocol therapy was given until disease progression or intolerance. The primary end point was overall survival (OS), and secondary end points were progression-free survival (PFS), objective response rate (RECIST 1.1), and safety. RESULTS Between September 2015 and May 2017, 432 patients were randomly assigned, 218 to ADX and 214 to PBO. The median OS was 12.5 versus 11.8 months in the ADX and PBO groups, respectively. The median PFS was 7.5 versus 7.1 months in the ADX and PBO groups, respectively. The objective response rate was 51% in the ADX group and 41% in the PBO group. Among the subgroup analyses, patients of age ≥ 65 years had an improved OS and PFS with ADX versus PBO; the P values and CIs were not adjusted for multiplicity. There were no meaningful differences in the safety profile of the ADX versus PBO groups. CONCLUSION The addition of ADX to mFOLFOX6 did not improve OS in unselected patients with untreated human epidermal growth factor receptor 2–negative gastric or GEJ adenocarcinoma.
A Survey of the Society for Pediatric Anesthesia on the Use, Monitoring, and Antagonism of Neuromuscular Blockade
Authors: Faulk Debra J. , Austin Thomas M. , Thomas James J. , Strupp Kim , Macrae Andrew W. , Yaster Myron 
Published: February 2021

BACKGROUND:
Although the package insert clearly states that “the safety and efficacy of sugammadex in pediatric patients have not been established,” we hypothesized that sugammadex is used widely in pediatric anesthetic practice supplanting neostigmine as the primary drug for antagonizing neuromuscular blockade (NMB). Additionally, we sought to identify the determinants by which pediatric anesthesiologists choose reversal agents and if and how they assess NMB in their practice. Finally, because of sugammadex’s effects on hormonal contraception, we sought to determine whether pediatric anesthesiologists counseled postmenarchal patients on the need for additional or alternative forms of contraception and the risk of unintended pregnancy in the perioperative period.

METHODS:
We e-mailed a questionnaire to all 3245 members of the Society of Pediatric Anesthesia (SPA) requesting demographic data and attitudes regarding use of NMB agents, monitoring, and antagonism practices. To address low initial response rates and quantify nonresponse bias, we sent a shortened follow-up survey to a randomly selected subsample (n = 75) of SPA members who did not initially respond. Response differences between the 2 cohorts were determined.

RESULTS:
Initial questionnaire response rate was 13% (419 of 3245). Overall, 163 respondents (38.9%; 95% confidence interval [CI], 34.2-43.8) used sugammadex as their primary reversal agent, and 106 (25.2%; 95% CI, 21.2-30.0) used it exclusively. Respondents with ≤5 years of practice used sugammadex as their primary reversal agent more often than those with ≥6 years of practice (odds ratio [OR]: 2.08; 95% CI, 1.31-3.31; P = .001). This increased utilization remained after controlling for institutional restriction and practice type (adjusted OR [aOR]: 2.20; 95% CI, 1.38-3.54; P = .001). Only 40% of practitioners always assess NMB (train-of-four), and use was inversely correlated with years of practice (Spearman ρ = −0.11, P = .04). Anesthesiologists who primarily used sugammadex assess NMB less routinely (OR: 0.56; 95% CI, 0.34-0.90; P = .01). A slim majority (52.8%) used sugammadex for pediatric postmenarchal girls; those with less experience used it more commonly (P < .001). Thirty-eight percent did not discuss its effects on hormonal contraception with the patient and/or family, independent of anesthesiologist experience (P = .33) and practice location (P = .38). No significant differences were seen in demographics or practice responses between initial and follow-up survey respondents.

CONCLUSIONS:
Sugammadex is commonly used in pediatric anesthesia, particularly among anesthesiologists with fewer years of practice. Failure to warn postmenarchal adolescents of its consequences may result in unintended pregnancies. Finally, pediatric anesthesia training programs should emphasize objective monitoring of NMB, particularly with sugammadex use.
Short Communication: Ethnozoology – The perception of Tobelo Dalam tribal community in Saolat Village, East Halmahera, Indonesia towards cuscus (Phalangeridae)
Authors: KUSUMANINGRUM ELIZABETH NOVI , SUPRIATNA JATNA , ABINAWANTO ABINAWANTO , BOWOLAKSONO ANOM 
Published: February 2021

Kusumaningrum EN, Supriatna J, Abinawanto, Bowolaksono A. 2018. Short Communication: Ethnozoology – The perception of Tobelo Dalam tribal community in Saolat Village, East Halmahera, Indonesia towards cuscus (Phalangeridae). Biodiversitas 19: 2140-2146. The complexity of the hard lives of Tobelo Dalam tribal community who live in Saolat village, district South Wasile provokes the high activity of animal poaching in Aketajawe-Lolobata National Park (TNAL) including cuscus hunting for both sale and consumption purposes. The study aimed to describe the traditional knowledge of Tobelo Dalam people in Saolat village in applying the systems of utilization and local conservation knowledge towards cuscus. This study was analyzed by the qualitative method with explorative survey technique, interview, and completing questionnaires. This study used 4 key informants (3 males, 1 female) and 50 adult respondents (25 males and 25 females). The results showed that the average percentage of traditional knowledge owned by males and females were 69.1% and 30.9 %, respectively, so the males had an advantage of knowledge around 38.3 % than females in addressing the traditional knowledge of cuscus. The community of Tobelo Dalam tribe hunts cuscus for four different purposes, i.e., for traditional ceremonies, traditional medicine, cuisine, and sell it for more income to support the economy of family.
Clinical and Genetic Risk Factors of Recurrent Nonalcoholic Fatty Liver Disease After Liver Transplantation
Authors: Satapathy Sanjaya K. , Tran Quynh T. , Kovalic Alexander J. , Bontha Sai Vineela , Jiang Yu , Kedia Satish , Karri Saradashri , Mupparaju Vamsee , Podila Pradeep S. B. , Verma Rajanshu , Maluf Daniel , Mas Valeria , Nair Satheesh , Eason James D. , Bridges Dave , Kleiner David E. 
Published: February 2021

INTRODUCTION:
Nonalcoholic fatty liver disease (NAFLD) has been increasingly reported among recipients of liver transplantation (LT). We aimed to identify clinical and genetic risk factors responsible for the development of early recurrent NAFLD in nonalcoholic steatohepatitis transplant recipients.

METHODS:
Forty-six total single nucleotide polymorphisms with known association with NAFLD were tested among both recipient and donor liver samples in 66 LT recipients with nonalcoholic steatohepatitis to characterize influences on NAFLD recurrence at ∼1 year post-LT (median interval from LT to biopsy: 377 days).

RESULTS:
Recurrent NAFLD was identified in 43 (65.2%) patients, 20 (30.3%) with mild recurrence, and 23 (34.8%) with moderate to severe NAFLD. On adjusted analysis, change in the body mass index (BMI) (ΔBMI) was significantly associated with NAFLD recurrence, whereas post-LT diabetes mellitus was associated with increased severity of NAFLD recurrence. ADIPOR1 rs10920533 in the recipient was associated with increased risk of moderate to severe NAFLD recurrence, whereas the minor allele of SOD2 rs4880 in the recipient was associated with reduced risk. Similar reduced risk was noted in the presence of donor SOD2 rs4880 and HSD17B13 rs6834314 polymorphism.

DISCUSSION:
Increased BMI post-LT is strongly associated with NAFLD recurrence, whereas post-LT diabetes mellitus was associated with increased severity of NAFLD recurrence. Both donor and recipient SOD2 rs4880 and donor HSD17B13 rs6834314 single nucleotide polymorphisms may be associated with reduced risk of early NAFLD recurrence, whereas presence of the minor allele form of ADIPOR1 rs10920533 in the recipient is associated with increased severity NAFLD recurrence.
El recuento automatizado de células en líquidos biológicos: una revisión
Authors: Alcaide Martín María José , Queral Laura Altimira , Frías Laura Sahuquillo , Valiña Amado Laura , Merino Anna , García de Guadiana-Romualdo Luis 
Published: February 2021

Resumen
El recuento de células en líquidos biológicos proporciona una información valiosa para el diagnóstico y tratamiento de diferentes patologías. El recuento en cámara y el estudio de la celularidad mediante microscopía óptica han sido consideradas tradicionalmente como método de referencia. Sin embargo, esta metodología implica un tiempo de respuesta del laboratorio elevado, carece de la reproducibilidad adecuada y requiere de personal experto. El avance tecnológico ha permitido el desarrollo de módulos de análisis específicos para los líquidos biológicos, incorporados en analizadores de hematología y de orinas, que permiten la automatización del recuento celular y han sido rápidamente incorporados a la práctica asistencial de los laboratorios En la actualidad diferentes analizadores están disponibles para ofrecer soluciones de automatización en el recuento de células en líquidos biológicos. Sin embargo, el empleo de dichos analizadores no está exento de limitaciones y su utilización requiere de un profundo conocimiento por los especialistas de la Medicina de Laboratorio. En esta revisión, se describen las principales tecnologías para la automatización del recuento celular en líquidos biológicos, el significado de los parámetros informados por los analizadores, sus principales características analíticas, así como el papel de la microscopía óptica en un contexto de utilización creciente de estas tecnologías.
Rheological behavior of a bentonite mud
Authors: Marum Daniela Martins , Afonso Maria Diná , Ochoa Brian Bernardo 
Published: February 2021

Abstract
Predicting drilling fluids rheology is crucial to control/optimize the drilling process and the gas extraction from drilling fluids in logging systems. A Couette viscometer measured the apparent viscosity of a bentonite mud at various shear rates and temperatures. The bentonite mud behaved as a yield-pseudoplastic fluid, and a modified Herschel-Bulkley model predicted the shear rate and temperature effects upon the shear stress. A pipe viscometer was built to seek a correlation between the mud flow rate and the pressure drop and thereby determine refined Herschel-Bulkley parameters. Coupling a rheological model to a pipe viscometer enables the continuous acquisition of apparent viscosities of Newtonian or non-Newtonian fluids at a rig-site surface.
Altruistic Punishment: The Golden Keystone of Human Cooperation and Social Stability?
Authors: Lewisch Peter 
Published: February 2021

Abstract
‘Altruistic punishment’ (i.e., costly punishment that serves no instrumental goal for the punisher) could serve, as suggested by the pertinent experimental literature, as a powerful enforcer of social norms. This paper discusses foundations, extensions, and, in particular, limits and open questions of this concept-and it does so mostly based on experimental evidence provided by the author. Inter alia, the paper relates the (standard) literature on negative emotions as a trigger of second party punishment to more recent experimental findings on the phenomenon of ‘spontaneous cooperation’ and ‘spontaneous punishment’ and demonstrates its (tight) emotional basis. Furthermore, the paper discusses the potential for free riding on altruistic punishment. While providing valuable insights into the understanding of social order, ‘altruistic punishment’ is thus not the golden keystone of social stability.
Précis: Our Moral Fate: Evolution And The Escape From Tribalism
Authors: Buchanan Allen 
Published: February 2021

Abstract
The book uses evolutionary principles to explain tribalism, a way of thinking and acting that divides the world into Us versus Them and achieves cooperation within a group at the expense of erecting insuperable obstacles to cooperation among groups. Tribalism represents political controversies as supreme emergencies in which ordinary moral constraints do not apply and as zero-sum, winner take all contests. Tribalism not only undermines democracy by ruling out compromise, bargaining, and respect for the Other; it also reverses one of the most important milestones of progress in how we understand morality: the insight that morality is not a list of commands to be unthinkingly followed, but rather that morality centrally involves the giving and taking of reasons among equals. Tribalism rejects this insight by branding the Other as a being who is incapable of reasoning.
Virtual simulation of otolith movement for the diagnosis and treatment of benign paroxysmal positional vertigo
Authors: Kong Lingyi , Wu Jun , Feng Mingjie , Zhang Yin , Liu Zhaobang , Yang Xiaokai 
Published: February 2021

Abstract
Benign paroxysmal positional vertigo (BPPV) is a clinical condition. The existing diagnostic methods cannot determine the specific location of otolith on the short or long brachial sides. Thus, visual and quantitative evaluation of the existing clinical standard diagnostic modality Dix–Hallpike test is needed to improve medical efficiency. Our goal was to develop a real-time virtual simulation system to assess a BPPV treatment manipulation. In this study, we used the proposed simulation system to observe otolith movement during a posterior semicircular canal BPPV diagnostic test, and to analyze the diagnostic mechanisms and strategies. Through visual cluster analysis of otolith position and analysis of otolith movement time in the standard Dix–Hallpike test, we can find that the positions of otoliths are relatively scattered, especially on the z-axis (z
1 = 10.67 ± 3.98), and the fall time of otoliths at different positions has relatively large changes (t
1 = 22.21 ± 1.40). But in the modified experiment z
2 = 4.93 ± 0.32 and t
2 = 26.21 ± 0.28. The experimental results show that the simulation system could track the state and the movement of otolith in real-time, which is of great significance for understanding the diagnostic mechanisms of BPPV evaluations and improving the diagnostic method.
A corpus-based study of the time orientation of qian “front” and hou “back” in Chinese
Authors: Wu Shuqiong 
Published: February 2021

Abstract
Based on corpus data and adopting a behavioral profile approach, this study examines the time orientation of Chinese words qian “front” and hou “back.” The corpus analysis yields the following findings. First, the primary temporal meaning of qian and hou is indicating time sequence, with qian meaning “earlier” and hou meaning “later.” Second, Chinese speakers tend to conceptualize the future as being ahead of them and the past behind them. Both qian and hou are found to refer to the past and the future. Their contradictory usage arises from the lack of a distinction between Ego-Reference-Point and Time-Reference-Point. Third, qian and hou are used mainly in five constructions as temporal words. Their constructional profiles reveal that their time orientation correlates with the constructions in which they occur. Based on the corpus results, I also discuss the motivations underlying their time orientation in various constructions and argue that their time orientation stems from an interplay of temporal metaphors, the constructions in which they occur, and context. These findings suggest that speakers’ metaphorical representations of time are shaped by a multitude of factors rather than single space-to-time mappings.
Null se constructions in Brazilian and European Portuguese: Morphosyntactic deletion or emergence of new constructions?
Authors: Soares da Silva Augusto , Afonso Susana , Palú Dafne , Franco Karlien 
Published: February 2021

Abstract

Se constructions designate a set of polysemous constructions along a transitivity continuum marked by the clitic se that perform various functions: reflexive/reciprocal, middle, anticausative, passive, and impersonal. A counterpart of these constructions without the clitic – the null se construction – is also attested. Based on an extensive usage-feature and profile-based analysis, and using multivariate statistical methods, we analyze, considering Cognitive Grammar, the conceptual, structural, and lectal factors that determine the choice between overt and null se constructions. The results of the study show that the null constructions are far more frequent in Brazilian (BP) than in European Portuguese (EP). In BP, the focus on the moment of change is a crucial factor for the overt/null variation in reflexive/reciprocal, middle, anticausative, and impersonal constructions. If the moment of the change of state is profiled, the overt se construction is usually produced. If the moment of change is not profiled, the null se construction is preferred. External factors also play a role in the variation. Register is an important predictor for the observed variation of the anticausative construction, and the only predictor for the overt/null variation in the case of the passive construction. In EP, the null se variant is mainly limited to anticausative constructions. In all cases of null constructions, there is a shift to an absolute construal, which has an impact on the way that the transitivity continuum is conceptualized.
Syzygies in equivariant cohomology in positive characteristic
Authors: Allday Christopher , Franz Matthias , Puppe Volker 
Published: February 2021

Abstract
We develop a theory of syzygies in equivariant cohomology
for tori as well as p-tori and coefficients in

𝔽
p

{\mathbb{F}_{p}}

.
A noteworthy feature is a new algebraic approach to the partial exactness
of the Atiyah–Bredon sequence, which also covers all instances considered so far.