bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transfusion practices for pediatric oncology and hematopoietic stem cell transplantation patients: Data from the National Heart Lung and Blood Institute Recipient Epidemiology and Donor Evaluation Study‐III (REDS‐III)
Authors: Goel Ruchika , Nellis Marianne E. , Karam Oliver , Hanson Sheila J. , Tormey Christopher A. , Patel Ravi M. , Birch Rebecca , Sachais Bruce S. , Sola‐Visner Martha C. , Hauser Ronald G. , Luban Naomi L. C. , Gottschall Jerome , Josephson Cassandra D. , Hendrickson Jeanne E. , Karafin Matthew S. ,   for the NHLBI Recipient Epidemiology and Donor Evaluation Study‐IV‐Pediatric (REDS‐IV‐P)
Published: August 2021

AbstractBackgroundTo evaluate transfusion practices in pediatric oncology and hematopoietic stem cell transplant (HSCT) patients.Study design and methodsThis is a multicenter retrospective study of children with oncologic diagnoses treated from 2013 to 2016 at hospitals participating in the National Heart Lung and Blood Institute Recipient Epidemiology and Donor Evaluation Study‐III. Transfusion practices were evaluated by diagnosis codes and pre‐transfusion laboratory values.ResultsA total of 4766 inpatient encounters of oncology and HSCT patients were evaluated, with 39.3% (95% confidence interval [CI]: 37.9%–40.7%) involving a transfusion. Red blood cells (RBCs) were the most commonly transfused component (32.4%; 95% CI: 31.1%–33.8%), followed by platelets (22.7%; 95% CI: 21.5%–23.9%). Patients in the 1 to <6 years of range were most likely to be transfused and HSCT, acute myeloid leukemia, and aplastic anemia were the diagnoses most often associated with transfusion. The median hemoglobin (Hb) prior to RBC transfusion was 7.5 g/dl (10–90th percentile: 6.4–8.8 g/dl), with 45.7% of transfusions being given at 7 to <8 g/dl. The median platelet count prior to platelet transfusion was 20 × 109/L (10–90th percentile: 8–51 × 109/L), and 37.9% of transfusions were given at platelet count of >20–50 × 109/L. The median international normalized ratio (INR) prior to plasma transfusion was 1.7 (10–90th percentile: 1.3–2.7), and 36.3% of plasma transfusions were given at an INR between 1.4 and 1.7.DiscussionTransfusion of blood components is common in hospitalized pediatric oncology/HSCT patients. Relatively high pre‐transfusion Hb and platelet values and relatively low INR values prior to transfusion across the studied diagnoses highlight the need for additional studies in this population.
Effects of rotational thromboelastometry–guided transfusion management in patients undergoing surgical intervention for postpartum hemorrhage: An observational study
Authors: Tsang Yiying (Sally) , Kurniawan Ade Rizki , Tomasek Owen , Hessian Elizabeth , Bramley David , Daly Oliver , Simons Koen , Imberger Georgina 
Published: August 2021

AbstractBackgroundPostpartum hemorrhage (PPH) can be associated with coagulopathy, which may be difficult to rapidly assess and may exacerbate blood loss. Rotational thromboelastometry (ROTEM) at the point of care can guide clinician choice of blood products and has been shown in some settings to reduce transfusions and improve outcomes. This hospital‐based observational study aims to measure effects of a ROTEM‐guided transfusion protocol on transfusion practice and clinical outcomes in patients with PPH managed in the operating theater.Study design and methodsWe compared a retrospective cohort of 450 consecutive patients with PPH treated in the operating theater before the introduction of a ROTEM‐guided transfusion algorithm in June 2016, with 450 patients treated after its introduction. Multivariate regression was used to evaluate the effect of ROTEM introduction on the primary outcome, patients requiring a packed red blood cell (PRBC) transfusion and adjusting for demographic and obstetric confounders. Secondary outcomes included other blood product transfusions, hysterectomy, and intensive care unit admission.ResultsA total of 90 (20%) of patients treated prior to ROTEM introduction received a PRBC transfusion, compared with 102 (22.7%) of those treated after ROTEM introduction (95% confidence interval [CI] 1.0–2.0, p = .04). There was no difference in PRBC transfusion in patients undergoing caesarean section (95% CI 0.5–1.8, p = .99). There was a trend toward increased use of cryoprecipitate and reduced use of platelets and fresh frozen plasma after ROTEM introduction.ConclusionIn our institution, the introduction of ROTEM‐guided transfusion did not reduce PRBC transfusion in patients with PPH treated in the operating theater.
How Central Asia to Escape from trade isolation?: Policy targeted scenarios by CGE modelling
Authors: Cheong Inkyo , Turakulov Valijon 
Published: September 2021

AbstractIt has been 30 years since Central Asian ‘‐stan’ countries, namely, Kazakhstan, Kyrgyzstan, Tajikistan, Turkmenistan and Uzbekistan, declared their independence in 1991. The Republics have chosen various transition paths from centrally planned to the market‐based economic system. The research found that Central Asian leaders’ protectionist policy, on top of the landlocked geographical environment, made trade costly, rendering these countries further isolated. Consequently, economic development slows down, unemployment increases and poverty rate extremes. Eventually, the isolated region (relatively, excluding Kazakhstan) is imprisoned in a low‐income trap and framed into a vicious circle. As a solution for tackling high‐trade costs in the region, this paper utilises the Global Trade Analysis Project (GTAP) Computational General Equilibrium (CGE) modelling to simulate the impacts of implementing policy‐targeted scenarios. The study presents that tariff reduction/elimination and trade facilitation policies could flourish the region by bringing significant economic welfare and robust GDP growth. The trade facilitation scenarios impact the region's economy much more positively than do tariff liberalisation scenarios.
A molecular phylogeny of Tetrastemma and its allies (Nemertea, Monostilifera)
Authors: Chernyshev Alexei V. , Polyakova Neonila E. , Norenburg Jon L. , Kajihara Hiroshi 
Published: September 2021

AbstractTetrastemma Ehrenberg, 1828, is one of the most speciose (~110 spp.) genera within the phylum Nemertea, comprising marine monostiliferans generally having four eyes. Monophyly of Tetrastemma remains open to question, having been tested to date only with 18S rRNA gene sequences targeting 13 species. Here, we examine the clade Tetrastemma with additional gene markers (18S rRNA, 28S rRNA, histone H3, 16S rRNA, and cytochrome c oxidase subunit I genes) and OTUs (66 specimens representing 53 species in Tetrastemma), along with a taxon sampling covering the entire Eumonostilifera. Our analysis revealed that Tetrastemma (a) as non‐monophyletic (as were Tetrastemmatidae) (b) contains a major clade consisting of four geographically cohesive subclades, whereas (c) Tetrastemma arcticum Uschakov, 1926; Tetrastemma bilineatum Coe, 1904; Tetrastemma vittigerum (Bürger, 1904); Tetrastemma wilsoni Coe, 1943; and two specimens tentatively identified as Tetrastemma sp. occur outside this major clade, and iv) the three species of Psammamphiporus Gibson, 1989, and Quasitetrastemma Chernyshev, 2004, nest within in the major Tetrastemma clade. Thus, we (a) synonymize Psammamphiporus and Quasitetrastemma with the senior name Tetrastemma and (b) establish Arctostemma gen. nov. for T. arcticum to yield Arctostemma arcticum (Uschakov, 1926) comb. nov.
Improved Pole-placement Control with Feed-forward Dead Zone Compensation for Position Tracking of Electro-Pneumatic Actuator System Improved Pole-placement Control with Feed-forward Dead Zone Compensation for Position Tracking of Electro-Pneumatic Actuato
Authors: Sunar Noorhazirah , Rahmat Mohd Fua’ad , Mohd Fauzi Ahmad ‘Athif , Ismail Zool Hilmi , Osman Siti Marhanis , Sulaiman Siti Fatimah 
Published: August 2021

Dead-zone in the valve degraded the performances of the Electro-Pneumatic Actuator (EPA) system. It makes the system difficult to control, become unstable and leads to chattering effect nearest desired position. In order to cater this issue, the EPA system transfer function and the dead-zone model is identified by MATLAB SI toolbox and the Particle Swarm Optimization (PSO) algorithm respectively. Then a parametric control is designed based on pole-placement approach and combine with feed-forward inverse dead-zone compensation. To reduce chattering effect, a smooth parameter is added to the controller output. The advantages of using these techniques are the chattering effect and the dead-zone of the EPA system is reduced. Moreover, the feed-forward system improves the transient performance. The results are compared with the pole-placement control (1) without compensator and (2) with conventional dead-zone compensator. Based on the experimental results, the proposed controller reduced the chattering effect due to the controller output of conventional dead-zone compensation, 90% of the pole-placement controller steady-state error and 30% and 40% of the pole-placement controller with conventional dead-zone compensation settling time and rise time.
Relationship Between Personality and Music Preferences Among University Students
Authors: Minnie Tai , Mahmud Norashikin , Wan Mohd Yunus Wan Mohd Azam , Nordin Nor Akmar 
Published: September 2021

This study analysed the relationship between Big Five personality traits and music preferences among university students. Big Five Inventory (BFI) and Short Test of Music Preferences (STOMP) was used to assess personality traits and music preferences. Questionnaires were distributed through social media platforms to college and university students aged 19 to 26. A total number of 145 respondents participated in this study. The results showed Agreeableness, Conscientiousness, and Openness were the most prevalent personality traits among respondents and Energetic-Rhythmic (ER) was the most preferred music. The correlation analysis showed that there is a significant correlation between Openness and energetic-rhythmic (ER) music. On the other hand, there was no significant correlation between other traits (Conscientiousness, Extraversion, Agreeableness, and Neuroticism) with music preference dimensions such as Intense-Rebellious (IR) and Energetic-Rhythmic (ER). The inconsistencies in the literature and our findings suggested more studies are needed to understand the influence of personality on music preferences.
Adipose‐related microRNAs as modulators of the cardiovascular system: the role of epicardial adipose tissue
Authors: Santos Diana , Carvalho Eugenia 
Published: August 2021

AbstractAdipose tissue expansion and subsequent metabolic dysfunction has been considered one of the major risk factors for development of cardiometabolic disease. Epicardial adipose tissue (EAT) in particular is a unique subtype of visceral adipose tissue located on the surface of the heart, around the coronary arteries. Due to its proximity, EAT can modulate the local metabolic and immune function of cardiomyocytes and coronary arteries. Several microRNAs have been described as key players in both cardiac and vascular function that when dysregulated will contribute to dysfunction. Here we review the influence of obesity in the crosstalk between specific adipose tissue types, in particular the EAT‐secreted microRNAs, as key modulators of cardiac disease progression, not only as early biomarkers but also as therapeutic targets for cardiometabolic disease.
image
A Parametric Examination of the Factors Affecting the Performance of a Diffusion Absorption Refrigeration System
Authors: Yousuf Noman Uddin , Anderson Timothy , Nates Roy 
Published: September 2021

Abstract
Despite being identified nearly a century ago, the diffusion absorption refrigeration (DAR) cycle has received relatively little attention. One of the strongest attractions of the DAR cycle lies in the fact that it is thermally driven and does not require high value work. This makes it a prime candidate for harnessing low-grade heat from solar collectors, or the waste heat from stationary generators, to produce cooling. However, to realize the benefits of the DAR cycle, there is a need to develop an improved understanding of how design parameters influence its performance. In this vein, this work developed a new, validated, parametric model that can be used by designers and practitioners to examine the performance of the DAR cycle for a range of operating conditions. The results showed that the cycle’s performance was particularly sensitive to several factors: the rate of heat added and the temperature of the generator, the effectiveness of the gas and solution heat exchangers, the mass flowrate of the refrigerant and the type of the working fluid. It was shown that it can deliver good performance at low generator temperatures if the refrigerant mass fraction in the strong solution is made as high as possible. Moreover, it was shown that a H2O–LiBr working pair could be useful for achieving cooling at low generator temperatures.
Search for signatures of sterile neutrinos with Double Chooz
Authors: Abrahão T. , Almazan H. , dos Anjos J. C. , Appel S. , Barriere J. C. , Bekman I. , Bezerra T. J. C. , Bezrukov L. , Blucher E. , Brugière T. , Buck C. , Busenitz J. , Cabrera A. , Cerrada M. , Chauveau E. , Chimenti P. , Corpace O. , Dawson J. V. , Djurcic Z. , Etenko A. , Furuta H. , Gil-Botella I. , Givaudan A. , Gomez H. , Gonzalez L. F. G. , Goodman M. C. , Hara T. , Haser J. , Hellwig D. , Heuermann L. , Hourlier A. , Ishitsuka M. , Jochum J. , Jollet C. , Kale K. , Kaneda M. , Karakac M. , Kawasaki T. , Kemp E. , de Kerret H. , Kryn D. , Kuze M. , Lachenmaier T. , Lane C. E. , Lasserre T. , Lastoria C. , Lhuillier D. , Lima Jr H. P. , Lindner M. , López-Casta no J. M. , LoSecco J. M. , Lubsandorzhiev B. , Maeda J. , Mariani C. , Maricic J. , Martino J. , Matsubara T. , Mention G. , Meregaglia A. , Miletic T. , Milincic R. , Minotti A. , Navas-Nicolás D. , Novella P. , Oberauer L. , Obolensky M. , Onillon A. , Oralbaev A. , Palomares C. , Pepe I. M. , Pronost G. , Reichenbacher J. , Reinhold B. , Schönert S. , Schoppmann S. , Scola L. , Sharankova R. , Sibille V. , Sinev V. , Skorokhvatov M. , Soldin P. , Stahl A. , Stancu I. , Stokes L. F. F. , Suekane F. , Sukhotin S. , Sumiyoshi T. , Sun Y. , Veyssiere C. , Viaud B. , Vivier M. , Wagner S. , Wiebusch C. , Yang G. , Yermia F. 
Published: August 2021

AbstractWe present a search for signatures of neutrino mixing of electron anti-neutrinos with additional hypothetical sterile neutrino flavors using the Double Chooz experiment. The search is based on data from 5 years of operation of Double Chooz, including 2 years in the two-detector configuration. The analysis is based on a profile likelihood, i.e. comparing the data to the model prediction of disappearance in a data-to-data comparison of the two respective detectors. The analysis is optimized for a model of three active and one sterile neutrino. It is sensitive in the typical mass range $${5 \times 10^{-3}}\,\mathrm{eV}^2 \lesssim \varDelta m^2_{41} \lesssim {3 \times 10^{-1}}\,\mathrm{eV}^2 $$

5
×

10

-
3

eV

2

≲
Δ

m
41
2

≲

3
×

10

-
1

eV

2

for mixing angles down to $$\sin ^2 2\theta _{14} \gtrsim {0.02} $$

sin
2

2

θ
14

≳

0.02

. No significant disappearance additionally to the conventional disappearance related to $$\theta _{13} $$

θ
13

is observed and correspondingly exclusion bounds on the sterile mixing parameter $$\theta _{14} $$

θ
14

as a function of $$ \varDelta m^2_{41} $$

Δ

m
41
2

are obtained.
Cosmological dynamics and bifurcation analysis of the general non-minimal coupled scalar field models
Authors: Khyllep Wompherdeiki , Dutta Jibitesh 
Published: August 2021

AbstractNon-minimal coupled scalar field models are well-known for providing interesting cosmological features. These include a late-time dark energy behavior, a phantom dark energy evolution without singularity, an early-time inflationary Universe, scaling solutions, convergence to the standard $$\Lambda $$
Λ
CDM, etc. While the usual stability analysis helps us determine the evolution of a model geometrically, bifurcation theory allows us to precisely locate the parameters’ values describing the global dynamics without a fine-tuning of initial conditions. Using the center manifold theory and bifurcation analysis, we show that the general model undergoes a transcritical bifurcation, predicting us to tune our models to have certain desired dynamics. We obtained a class of models and a range of parameters capable of describing a cosmic evolution from an early radiation era towards a late time dark energy era over a wide range of initial conditions. There is also a possible scenario of crossing the phantom divide line. We also find a class of models where the late time attractor mechanism is indistinguishable from a structurally stable general relativity-based model; thus, we can elude the big rip singularity generically. Therefore, bifurcation theory allows us to select models that are viable with cosmological observations.
Latest Inversion-Free Iterative Scheme for Solving a Pair of Nonlinear Matrix Equations
Authors: Shil Sourav , Nashine Hemant Kumar 
Published: August 2021

In this work, the following system of nonlinear matrix equations is considered,

X

1

+

A

∗

X
1

−
1

A
+

B

∗

X
2

−
1

B
=
I
and

X

2

+

C

∗

X
2

−
1

C
+

D

∗

X
1

−
1

D
=
I
,

where

A
,
B
,
C
,
and
D

are arbitrary

n
×
n

matrices and

I

is the identity matrix of order

n

. Some conditions for the existence of a positive-definite solution as well as the convergence analysis of the newly developed algorithm for finding the maximal positive-definite solution and its convergence rate are discussed. Four examples are also provided herein to support our results.
Metabolomics as a Tool for Biomarker Discovery in Gastric Cancer
Authors: Drew David A. , Klempner Samuel J. , Chan Andrew T. 
Published: September 2021

Abstract
Globally, early detection and interception of gastric cancer remains limited by the lack of a broad screening paradigm for individuals with the exception of those at established hereditary risk (e.g., hereditary diffuse gastric cancer or CDH1 germline mutation status). The path forward will likely rely on establishment of biomarkers using multiple -omic approaches to detect molecular profiles associated with gastric cancer risk that can in turn be leveraged to identify individuals who may benefit from more intensive evaluation, such as screening endoscopy. In this issue, Shu and colleagues describe the results of a case-control cohort study of Asian individuals that demonstrates baseline metabolite levels are predictive of future gastric cancer risk above and beyond lifestyle and demographic risk factors. We discuss the promise and limitations of these exemplar circulating biomarkers and emphasize the need for a multifactorial risk assessment to advance precision prevention and early detection of gastric cancer.
See related article by Shu et al., p. 1634
ГОСТРІ ПОРУШЕННЯ МОЗКОВОГО КРОВООБІГУ У ХВОРИХ НА COVID-19
Authors: Муратова Т. М. , Храмцов Д. М. , Ворохта Ю. М. , Вікаренко М. С. , Добуш І. В. , Козлова Г. Г. , Андрющенко Є. О. , Сазонов В. М. , Фащенко В. А. 
Published: September 2021

У грудні 2019 року з міста Ухань (провінція Хубей, Китай) надійшли перші повідомлення про COVID-19 – захворювання, спричинене новим тяжким гострим респіраторним синдромом коронавірусної етіології (SARS-CoV-2). З цього часу ця хвороба стала світовою пандемією. На сьогоднішній день загинуло понад 2,8 мільйона осіб (ВООЗ, 2021). Вірус SARS-CoV-2 став сьомим відомим варіантом коронавірусу, патогенним для людини.
Метою огляду була оцінка впливу інфекції SARS-CoV-2 на поширеність ГПМК у країнах світу.
Матеріал і методи. Ретроспективне дослідження проведене за матеріалами міжнародних баз даних (CDC, ВООЗ), а також реєстрів ГПМК (SITS, resQ, DAP, GSR, SSR, LASE). Проведене зіставлення інкременту захворюваності на SARS-CoV-2 та ГПМК у динаміці з моменту виявлення перших випадків COVID-19. Статистичну обробку проводили за допомогою програмного забезпечення Statistica 13.0 (TIBCO Inc., США).
Результати. Частота ГПМК у світі корелює з поширеністю SARS-CoV-2. На ранніх стадіях пандемії COVID-19 відбувалося меншення захворюваності на ГПМК у розвинутих країнах. Існуючі міжнародні реєстри ГПМК відображають збереження цієї тенденції.
Висновки. 1. Пандемія COVID-19 пов᾽язана із глобальним зменшенням звернення за спеціалізованою медичною допомогою при ГПМК, що впливає на загальну кількість госпіталізацій та число процедур механічної тромбектомії. 2. Незважаючи на географічні розбіжності, це зменшення обсягу спостерігалося незалежно від тягаря госпіталізації COVID-19 та обсягів госпіталізації хворих з ГПМК у допандемічний період.
Native Aortic Valve Disease Progression and Bioprosthetic Valve Degeneration in Patients With Transcatheter Aortic Valve Implantation
Authors: Kwiecinski Jacek , Tzolos Evangelos , Cartlidge Timothy R.G. , Fletcher Alexander , Doris Mhairi K. , Bing Rong , Tarkin Jason M. , Seidman Michael A. , Gulsin Gaurav S. , Cruden Nicholas L. , Barton Anna K. , Uren Neal G. , Williams Michelle C. , van Beek Edwin J.R. , Leipsic Jonathon , Dey Damini , Makkar Raj R. , Slomka Piotr J. , Rudd James H.F. , Newby David E. , Sellers Stephanie L. , Berman Daniel S. , Dweck Marc R. 
Published: August 2021

Background:
Major uncertainties remain regarding disease activity within the retained native aortic valve, and regarding bioprosthetic valve durability, after transcatheter aortic valve implantation (TAVI). We aimed to assess native aortic valve disease activity and bioprosthetic valve durability in patients with TAVI in comparison with subjects with bioprosthetic surgical aortic valve replacement (SAVR).

Methods:

In a multicenter cross-sectional observational cohort study, patients with TAVI or bioprosthetic SAVR underwent baseline echocardiography, computed tomography angiography, and
18
F-sodium fluoride (
18
F-NaF) positron emission tomography. Participants (n=47) were imaged once with
18
F-NaF positron emission tomography/computed tomography either at 1 month (n=9, 19%), 2 years (n=22, 47%), or 5 years (16, 34%) after valve implantation. Patients subsequently underwent serial echocardiography to assess for changes in valve hemodynamic performance (change in peak aortic velocity) and evidence of structural valve dysfunction. Comparisons were made with matched patients with bioprosthetic SAVR (n=51) who had undergone the same imaging protocol.

Results:

In patients with TAVI, native aortic valves demonstrated
18
F-NaF uptake around the outside of the bioprostheses that showed a modest correlation with the time from TAVI (
r
=0.36,
P
=0.023).
18
F-NaF uptake in the bioprosthetic leaflets was comparable between the SAVR and TAVI groups (target-to-background ratio, 1.3 [1.2–1.7] versus 1.3 [1.2–1.5], respectively;
P
=0.27). The frequencies of imaging evidence of bioprosthetic valve degeneration at baseline were similar on echocardiography (6% versus 8%, respectively;
P
=0.78), computed tomography (15% versus 14%, respectively;
P
=0.87), and positron emission tomography (15% versus 29%, respectively;
P
=0.09). Baseline
18
F-NaF uptake was associated with a subsequent change in peak aortic velocity for both TAVI (
r
=0.7,
P
<0.001) and SAVR (
r
=0.7,
P
<0.001). On multivariable analysis,
18
F-NaF uptake was the only predictor of peak velocity progression (
P
<0.001).

Conclusions:
In patients with TAVI, native aortic valves demonstrate evidence of ongoing active disease. Across imaging modalities, TAVI degeneration is of similar magnitude to bioprosthetic SAVR, suggesting comparable midterm durability.

Registration:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT02304276.