bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early-term surgical outcomes after correction of total anomalous pulmonary venous connection
Authors: Plotnikov M. V. , Gorbatykh Yu. N. , Arkhipov A. N. , Omelchenko A. Yu. , Galstyan M. G. , Ivanzov S. M. , Bogachev-Prokophiev A. V. , Soynov I. A. 
Published: June 2021

Highlights. The geometry of the left atrium and the growth of the left heart after correction of total anomalous pulmonary venous connection are evaluated for the first time.Aim. To assess the morphological and functional characteristics of the left heart after correction of total anomalous pulmonary venous connection.Methods. 40 patients referred to the correction of total anomalous pulmonary venous connection were enrolled in a pilot, two-center, simple, blind, prospective randomized study. Patients were assigned to the sutureless repair group (n = 20) and conventional repair group (n = 20).Results. In the early postoperative period, the indexed left atrial volume in the group of sutureless repair was 15 (13.65; 17.25) versus 12.85 (10.95; 15.15) in the group of conventional repair, p = 0.057. The end diastolic volume index in the sutureless repair group was 38 (28.5; 45), while in the conventional repair group - 37.1 (31; 47.75), p = 0.48. At the follow-up, the indexed left atrial volume in the group of sutureless repair was 37 (34.5; 38.9) versus 31 (23.6; 35) in the group of conventional repair, p = 0.01. The end diastolic volume index (EDVI) in the group of sutureless repair was 50 (43; 57), while in the group of conventional repair - 50.2 (28.8; 60.9), p = 0.49.Conclusion. The growth of the left atrium depended on the chosen technique for correcting total anomalous pulmonary venous connection and was higher in the group of sutureless repair (37) compared to the group of conventional repair (31). The proportionality of the growth of the left ventricle did not depend on the surgical technique and was equivalent in both groups.
Vascular remodeling after everolimus-eluting stent implantation in non-ST segment elevation acute coronary syndrome: optical coherence tomography
Authors: Trusov I. S. , Biryukov A. V. , Nifontov E. M. , Ivanchenko R. D. , Melioranskaia E. I. 
Published: June 2021

Highlights. Vascular healing response after stenting depends on both, procedure- and patient-related factors. The patient's age, lipid metabolism, the presence of heart failure, myocardial infarction, and the thickness of epicardial adipose tissue affect vascular remodeling after everolimus-eluting stent implantation.Aim. To identify factors affecting vascular healing response after everolimus-eluting stent implantation in patients with non-ST segment elevation acute coronary syndrome.Methods. 45 patients with non-ST segment elevation acute coronary syndrome who underwent everolimus-eluting stent implantation were included in a study. Stenting was performed without intravascular imaging guidance. All patients underwent repeated coronary angiography and optical coherence tomography of the stented segment 6 (±2) months after the indexed procedure. 39,860 struts in 4,576 sections were analyzed. The number of uncovered and malapposed struts was estimated, and the healing score was calculated. Cardiovascular death, repeated myocardial infarction, and repeated revascularization of the stented segment 12 months after the stenting were evaluated as a combined endpoint.Results. 5 patients out of 45 reached the endpoint (11.1%), the main component of which was repeated revascularization. Patients who reached the endpoint had a lower healing score (4.5±2.6 and 19.9±17.9, respectively; p = 0.038). The healing score was lower in men (13.7±14.7 and 26.0±20.0, respectively; p = 0.041), those who had myocardial infarction at the time of stenting (5.5±6.7 for myocardial infarction and 19.8±17.9 for unstable angina, p = 0.045), and those who did not have heart failure (12.2±12.4 and 36.7±19.0, respectively; p = 0.0006). The healing score depended on the severity of the coronary lesion (24.8±19.4 for multivessel lesions, 10.0±8.7 for single-vessel lesions, and 7.3±6.3 for two-vessel lesions, respectively; p = 0.019). The linear regression reported the correlation of the healing score with age, atherogenicity coefficient, and the presence of chronic heart failure. The modified healing score depended on the epicardial fat thickness, atherogenicity coefficient, and blood urea level.Conclusion. The nature and degree of vascular remodeling after everolimus-eluting stent implantation depends on the patient's age, diagnosis, heart failure, lipid metabolism, and the severity of the coronary lesion. The evaluation of vascular healing response may influence the decision on the duration of dual antiplatelet therapy
Predictors to quality of life improvements in patients with chronic coronary total occlusion depending on the selected treatment strategy
Authors: Badoian A. G. , Krestyaninov O. V. , Khelimskii D. A. , Ibragimov R. U. , Naydenov R. A. 
Published: June 2021

Highlights. The impact of clinical, angiographic and procedure-related factors on the quality of life of patients with chronic coronary total occlusions has been reported.Background. The impact of patient-related factors including clinical and angiographic data and procedure-related factors on the quality of life remains debating.Aim. To assess the impact of baseline and procedure-related factors on the quality of life in patients with chronic coronary total occlusion.Methods. 140 patients with chronic single-vessel disease randomly assigned either to the invasive-strategy group or the conservative-strategy group. Quality of life was measured in all patients using the Seattle Angina Questionnaire, European Quality of Life Survey, and Rose Dyspnea Scale after 3 and 12 months. To determine the predictors to the quality of life improvements in both groups, simple and multivariate regression analysis were performed. The baseline clinical, angiographic and procedure-related factors were included in the analysis.Results. The technical success of the procedure was the independent predictor to quality of life improvement in the invasive-strategy group (OR: 5.8, 95%, CI: 3,26-9.18, p = 0.001). The absence of diabetes mellitus (OR: 0.19, 95%, CI: 0.09-0.84, p = 0.04), CTO of other than left anterior descending artery (OR: 2.1, 95%, CI: 1.09-4.0, p = 0.03) and higher SAQ - 7 score at baseline (OR: 1.1, 95%, CI: 1.04-1.21, p = 0.02) independently predicted the improvements in the quality of life. The indicators of quality of life between the subgroups of subintimal and intraluminal recanalization did not differ significantly in the long-term period. The total SAQ-7 score in the subintimal recanalization subgroup was 85.5 ± 9.1 versus 89.3 ± 9.6 in the intraluminal recanalization subgroup (p = 0.21).Conclusion. The decision on the management of patients with chronic coronary total occlusions should be made individually, taking into account baseline clinical and instrumental data. The recanalization technique does not affect the quality of life. Its choice should be made individually in order to achieve technical success.
2020 Russian and European clinical practice guidelines for the management of NSTEMI patients: have approaches to antithrombotic therapy been simplified?
Authors: Barbarash O. L. , Kashtalap V. V. 
Published: June 2021

Highlights. Prescribtion patterns of antithrombotic therapy in patients with non-ST-segment elevation acute coronary syndromes have been comapred in 2020 Russian and European clinical practice guidelines for the management of NSTEMI patients.A comparative assessment of novel approaches of antiplatelet and anticoagulant therapy recommended in 2020 European and Russian clinical practice guidelines for the management of patients with non-ST-segment elevation acute coronary syndrome is reported. In prescribing antiplatelet therapy, ESC guidelines suggest focusing attention on a more complex set of regimens to balance ischemic and hemorrhagic risks. Approaches to prescribing anticoagulant therapy do not differ in the recommendations of two medical societies. Fondaparinux has compelling advantages over other drugs regarding the combination of efficacy and safety in patients.
HOW CAN THE SURGE OF SECTARIAN INTOLERANCE IN PAKISTAN BE TACKLED? BRIDGING THE WIDENING DIVIDE
Authors: Mehfooz Musferah , Parveen Safia 
Published: June 2021

Problem and aim of the study: This article deals with the causes of the scary rise of sectarian Intolerance, violence, and prejudices in Pakistan. This article also investigates that how sectarian intolerance causes violence in society and what strategies should imply to curtail sectarianism from society?
Research methods: The research is qualitative, and applies the inductive and deductive methodology to the collected data. The data has been derived from the South Asian Terrorism Portal and to analyze the authenticity the author has collected the shared information from published articles, researches, and government official website that provide the statistics about violence and terrorism.
Main findings: The study concludes by arguing the dire need for the promulgation and dissemination of inclusive thoughts for attaining a tolerant society free from sectarian intolerance because the implications of sectarian violence are a great threat to the peace process in the country.
Application of the study: This study has significant implications from both a theoretical and a realistic perspective. The present study would be useful for policy-makers, to curtail the sectarianism in State. Therefore, the banning of sectarian speeches, sectarian literature, has been strongly suggested. The government should place a moratorium on the printing of sectarian literature for sectarian unity. The study also has tried to make realize to the state actors, including security forces and intelligence agencies, to avoid blame foreign involvement in sectarian polarization and why they ignore the fault lines destabilizing Pakistan's social fabric since Pakistan's inception. Therefore, the study would doubtlessly help decrease unpleasant incidents and reduce religious fanaticism.
Originality and novelty of the study: This is the fact that in the existing literature the least attention has been given to sectarianism in Pakistan. The present study aims to deals with the social, religious, and political aspects of sectarian violence. Therefore, this is the first study that has investigated sectarian violence by exploring the issue of sectarianism from a social, religious, and political perspective.
REVEALING THE EFFECTS OF TEACHERS STIMULATING TECHNOLOGICAL INCLUSION ON UNIVERSITY STUDENTS EDUCATIONAL GAINS: A COMPARATIVE STUDY
Authors: Hassan Mehboob Ul , Nawaz Haq , Faiz Abu Ul Hassan 
Published: June 2021

Purpose of the Study: The purpose of the current research was to measure the effect of male and female teachers technological inclusion used to stimulate university students educational gains. The research have intends to determine the effect of current practices occurring in public and private universities of District Lahore of the Province-Punjab.
Methodology: The researchers structured quantitative research leading to a positivist paradigm adopting ex post facto design to determine the effect of public and private universities teachers stimulating technological inclusion on students educational gains. The researchers administered a self-constructed questionnaire on a sample of 600 respondents. The researchers ran regression analysis and independent-sample t-test to find out effect and comparison.
Main findings: Findings of regression analysis revealed that teachers stimulating technological inclusion affect 68.70% of students educational gains whereas critical thinking and problem solving 66.70%, creativity and innovation 66.70% and, health issues affect 69.10% of students educational gains. Male teachers were more stimulating their technological inclusion as compared to female teachers. Likewise, private sector university teachers were more stimulating their technological inclusion on their students educational gains as compared to public sector university teachers.
Applications of this study: The results of the current research will be applicable for male and female sector universities teachers working in public and private sectors. They will be realistically aware of the actual use of their technological inclusion used to stimulate their students enrolled in other provinces of the Pakistan including Punjab for acquiring better educational gains. The findings of the research will be pertinent to provoke the intends of future research scholars to establish the effect of technological inclusion on social, political, economical, and cultural transformations aspects, unfolding the technological dimensions of artifact, knowledge, process, and volition.
Novelty/originality of this study: The researchers days-and-nights effort bring fruitful consequences in contributing to this evidence-based literature to the existing body of knowledge in the field of teachers technological inclusion. The authors have tremendously determined the effects of teachers technological inclusion used to stimulate university students didactic learning which was never done before from a Pakistani Perspective. The researchers have covered a similar topic to ensure the relevancy, accuracy, and uniformity to engage the attentions of the readers in data sharing.
Análise comparativa da mobilidade ocupacional entre homens e mulheres estrangeiros no mercado formal de trabalho brasileiro / Comparative analysis of occupational mobility between foreign men and women in Brazil’s formal labour market
Authors: Noronha Claudia Lima Ayer de , Vilela Elaine Meire 
Published: June 2021

Esse artigo objetiva analisar: i) se mulheres e homens estrangeira(o)s têm padrões de mobilidade ocupacional diferentes no mercado de trabalho formal brasileiro; ii) se as mulheres têm menores probabilidades de mobilidade ascendente, quando compa-radas aos seus conterrâneos; iii) e se as chances de mobilidade ascendente entre es-trangeiros e estrangeiras no mercado de trabalho formal brasileiro se diferenciam por grupo de nacionalidade. Para tanto, utilizamos os dados das Relações Anuais de In-formações Sociais (RAIS) de 1995 a 2015 que se referem somente aos trabalhadore(a) s empregado(a)s no mercado formal. Os resultados evidenciam que não são todos os grupos de estrangeiros que apresentam chances de mobilidade diferentes entre homens e mulheres, pois depende da nacionalidade do indivíduo. Para aqueles que apresentam divergências, as chances de mobilidade ascendente são maiores para os estrangeiros comparados às estrangeiras. In this article we analyse whether: i) foreign women and men exhibit different occupational mobility patterns in Brazil’s formal labour market; ii) foreign women are less likely to experience upward mobility than their male peers; and iii) the chances of upward mobility among foreign women and men in Brazil’s formal labour market differ by nationality. To examine these questions, we use the data from the Annual Social Information Reports (RAIS) from 1995 to 2015, which refer exclusively to workers employed in the formal labour market. The results demonstrate that the chances of mobility of men and women do not differ among all groups of foreigners, since this difference is dependent on the nationality concerned. For those groups that do show differences, the chances of upward mobility are higher among men than women.
A Migração Haitiana e a Construção de seus "Nortes": Brasil um "Norte" Alternativo e Temporário
Authors: Diémé Kassoum , Tonhati Tania Mara Passarelli , Pereda Cordova Lorena del Pilar 
Published: June 2021

Desde 2010, o número de imigrantes do “Sul Global”no Brasilcresce. A imigração de haitiana, aqui analisada, é caracterizada pelapermanência, circularidade etransitoriedade. Procurado para melhorar de vida, o Brasil é percebidopelos migrantes como umlugardeacumular capitais de mobilidade e expandir acircularidade atéo “Norte Global”. Diante disso, o Brasil se transformouno que Baganha (2002) denomina“uma placa giratória”?Este artigo analisou dados deum projeto de pesquisa do LAEMI(UnB),junto com a UFPR, apoiados pela FAP-DF. A metodologiafoi multisituada, com camposno Brasil eno Haitiem 2018-2019.Observamos queem geral o Brasil é um “Norte Global alternativo” no Sul Global, sendo uma “placa giratória” amenae um “Norte temporário” que tende a se eternizar. Since 2010, Brazil has experienced international migration with greater intensityand complexity. One of the most significant changes faced by the country was the arrival of new migratory flows, especially from Haiti. The Haitian immigration in Brazil has been consolidated and the present study aims to understand: which role Brazil plays in the migratory projects of Haitians? To answer this question, we rely on data from the research named: Immigration and economic crisis: the migratory tac-tics of return and circularity of Haitians. The fieldwork was carried out in Brazil and Haiti, between 2018 and 2019. The results found were that Brazil is seen frequently reported as an “Alternative and Temporary North”, where it is possible to accumulate capital of mobility, education and economic, which allow them expanding their mi-gratory circularity’s horizons.
Carbonatite-Like Rock in a Dike of the Aikhal Kimberlite Pipe: Comparison with Carbonatites of the Nomokhtookh Site (Anabar Area)
Authors: Kostrovitsky S.I. , Yakovlev D.A. , Suvorova L.F. , Demonterova E.I. 
Published: June 2021

Abstract
––A dike of rock similar in composition to carbonatites has been found in the Aikhal diamondiferous pipe of the Alakit–Markha field of the Yakutian kimberlite province (YaKP). The fine-grained rock of essentially carbonate composition (dolomite and calcite) rich in thin-platy phlogopite contains minerals typical of carbonatites: monazite, baddeleyite, and pyrochlore. In the high contents and distribution of incompatible elements the rock differs significantly from kimberlites and is transitional from kimberlites to carbonatites. The content of incompatible elements in this rock is 3–5 times lower than that in carbonatite breccias of the pipes in the Staraya Rechka kimberlite field of the YaKP (Nomokhtookh site). The compositions of accessory trace element minerals from the Aikhal dike rock and the Nomokhtookh carbonatite breccias are compared. An assumption is made that the high contents of incompatible elements in the carbonatite-like rock, which caused the crystallization of accessory minerals, are due to the differentiation of kimberlite melt/fluid. The high Sr isotope ratios indicate that the rock altered during hydrothermal and metasomatic processes. The obtained data on the composition of the carbonatite-like rock cannot serve as an argument for the genetic relationship between the Aikhal kimberlites and typical carbonatites. The genetic relationship between kimberlites and carbonatites in the northern fields of the YaKP remains an open issue.
Vendian Island-Arc Intrusive Magmatism of the Lake Zone of Western Mongolia (Geological, Geochronological, and Petrochemical Data)
Authors: Rudnev S.N. , Gibsher A.S. , Semenova D.V. 
Published: June 2021

Abstract
—Based on new geochronological data on gabbroid and plagiogranitoid associations (Tavan-Hayrhan, East Bayan Tsagaan, Bayan Tsagaan Uul, Tungalag, Three Hills, and Shutkhuin massifs) located among the Vendian island-arc volcanic complexes of the Lake Zone of Western Mongolia, an independent stage of Vendian island-arc intrusive magmatism (560–542 Ma) is substantiated. Geochronological ages determined by xenogenic zircon from Vendian gabbroids and granitoids (716–559 Ma) indicate a wide time interval of their formation and different natures of the sources. Several such sources are assumed. The source of the first type is rocks of the late Riphean oceanic crust of the Paleoasian Ocean, on which the Vendian island arc of the Lake Zone formed later. This is evidenced by the presence of xenogenic zircon with the ages of ~716, 658–642, 613–611 Ma. The source of the second (probably main) type is rocks of the Vendian island-arc crust of the Lake Zone. This is indicated by the presence of xenogenic zircon with ages of 583–559 Ma, observed in all studied Vendian intrusive associations.
In Vitro and In Silico Studies of Two 1,4-Naphthoquinones and Their Topical Formulation in Bigels
Authors: Khelifi Imen , Tourrette Audrey , Khelifi Daycem , Efferth Thomas , Hayouni El Akrem , Ksouri Riadh , Bouajila Jalloul 
Published: June 2021

Background:
1,4-Naphthoquinones (1,4-NQs) are secondary plant metabolites with numerous
biological activities. 1,4-NQs display low water solubility and poor bioavailability. Bigels
are a new technology with great potential, which are designated as drug delivery systems. Biphasic
bigels consisting of solid and liquid components represent suitable formulations improving diffusion
and bioavailability of NQs into the skin.

Objective:
We evaluated the in silico and in vitro activity of 5,8-dihydroxy-1,4-naphthoquinone
(M1) and 2,3-dichloro-5,8-dihydroxy-1,4-naphthoquinone (M2) on elastase and assessed their cytotoxicity
towards COLO38 melanoma cells. The 1,4-NQs were loaded into bigels for topical application.

Methods:
Molecular docking was performed, and cytotoxicity was evaluated on COLO38 cells using
the resazurin assay. M1 and M2 were separately incorporated into bigels consisting of hydrogel
organogel with sweet almond oil as the non-polar solvent and span 65 as an organogelator.
Their rheological behavior and microscopic properties were characterized. The diffusion kinetics
and permeation of 1,4-NQs from bigels were studied by a paddle-over-extraction cell and a “Franz
cell” in vitro permeation model.

Results:
Molecular docking data predicted high interactions between elastase and ligands. Hydrogen
bonds with LYS233 were observed for M1, M2, and phosphoramidon (positive control). The
average binding energies were -8.5 and -9.7 kcal/mol for M1 and M2 and -12.6 kcal/mol for phosphoramidon.
M1 and M2 inhibited the elastase activity by 58.9 and 56.6%, respectively. M1 and
M2 were cytotoxic towards COLO38 cells (IC50 value: 2.6 and 9.8 μM). The M1 release from
bigels was faster and more efficient than that of M2.

Conclusion:
M1 and M2 are promising for skin disease treatment. Biphasic organogel-hydrogel
bigels are efficient and safe formulations to overcome their low bioavailability.
Benzodiazepines and Sleep Architecture: A Systematic Review
Authors: Sousa Martins Silva Anderson , de Mendonça Felipe Maraucci Ribeiro , de Mendonça Giulia Paulo Rossi Ribeiro , Souza Laura Costa , Galvão Lucas Pequeno , Paiva Henrique Soares , de Azevedo Marques Périco Cintia , Torales Julio , Ventriglio Antonio , Maurício Castaldelli-Maia João 
Published: June 2021

Background:
Insomnia, defined as a difficulty in initiating or maintaining sleep, is a relevant
medical issue. Benzodiazepines (BZDs) are commonly prescribed to treat insomnia. Two
phases characterize human sleep structure: sleep with Non-Rapid Eye Movement (NREM) and
sleep with Rapid Eye Movement (REM). Physiological sleep includes NREM and REM phases in
a continuous cycle known as “Sleep Architecture.”

Objective:
This systematic review summarizes the studies that have investigated effects of BZDs
on Sleep Architecture.

Methods:
The articles selection included human clinical trials (in English, Portuguese, or Spanish)
only, specifically focused on BZDs effects on sleep architecture. PubMed, BVS, and Google Scholar
databases were searched.

Results:
Findings on BZDs effects on sleep architecture confirm an increase in stage 2 of NREM
sleep and a decrease in time of stages 3 and 4 of NREM sleep with a reduction in time of REM
sleep during the nocturnal sleep.

Conclusion:
Variations in NREM and REM sleep may lead to deficits in concentration and working
memory and weight gain. The increase in stage 2 of NREM sleep may lead to a subjective improvement
of sleep quality with no awakenings. BZDz should be prescribed with zeal and professional
judgment. These patients should be closely monitored for possible long-term side effects.