bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fabrication of Ultrathin Membranes Using 2D‐MOF Nanosheets for Tunable Gas Separation
Authors: Li Yuxiao , Wang Ting , Liu Dahuan 
Published: August 2021

AbstractTwo‐dimensional (2D) metal‐organic frameworks (MOF) nanosheets have emerged as novel membrane materials for gas separation. However, the development of ultrathin MOF membranes with tunable separation performances is still a challenge. Herein, we developed a facile GO‐assisted restacking method to fabricate defect‐free membranes with monolayer Zr‐BTB nanosheets. Obtained ultrathin membranes ranging from 130 nm to 320 nm show tunable separation performances and exceed the 2008 Robeson upper bound by changing the amount of nanolayers in vertical stacking direction. Furthermore, a heating filtration method was used to change the restacking process of nanosheets in the horizontal direction. As a result, H2/CO2 selectivity can be enhanced by two times with the same membrane thickness (130 nm) and H2 permeance is almost maintained to be 7.0×10−7 mol m−2 s−1 pa−1. This method may provide a possible way to efficiently tune the gas separation performances of MOF membranes.
Difference in the lightning frequency between the July 2018 heavy rainfall event over central Japan and the 2017 northern Kyushu heavy rainfall event in Japan
Authors: Sato Yousuke , Hayashi Syugo , Hashimoto Akihiro 
Published: August 2021

AbstractThe causes for the differences in the lightning frequency between two heavy rainfall events, the 2017 northern Kyushu heavy rainfall event and the 2018 heavy rainfall event in central Japan, were examined using a numerical model coupled with an explicit bulk lightning model. These heavy rainfall events occurred near the Baiu frontal system of Japan in July, but the characteristics of rainfall differed. The former case was categorised as an extreme rainfall and extreme convective event by previous satellite observational studies, and the lightning frequency was high. Conversely, the latter case was categorised as an extreme rainfall without extreme convection event, and the lightning frequency was low. The numerical model used in this study successfully reproduced the differences in the lightning frequency between the two cases. Our analyses indicated that the differences in the lightning frequency between the two cases were attributed to the differences in the vertical structure of the charge separation rate and the charge density, which originated from the difference in the vertical distribution of graupel.
The pandemic and resilience for the future: AccBio 2021
Authors: McGovern Āine T. , Salisbury Cleo M. , Nyberg Gregg B. 
Published: August 2021

AbstractThe year 2020 brought the onslaught of a global crisis in the form of the COVID‐19 pandemic. While nearly every facet of everyday life and work was impacted by the pandemic, the biopharmaceutical industry found silver linings in innovation, partnership, and resiliency, all of which contributed to unprecedented speed in developing and delivering vaccines and therapies. The 7th International Conference on Accelerating Biopharmaceutical Development (AccBio 2021) brought together industry leaders to share experiences from the past year and discuss how lessons learned from the pandemic can be carried forward into the future of biopharmaceutical development. Presenters highlighted examples such as introducing biotherapeutics derived from non‐clonal cell pools into the clinic, developing modular or platform technologies, and taking novel risks, among others. These strategies for enabling speed to clinic and launch, as well as for sustaining a robust supply chain, are likely to be integrated into future programs to ensure biomanufacturing resiliency and get medicines to patients faster than pre‐pandemic times.
Application of VR technology in civil engineering education
Authors: Wang Chen , Tang Yutong , Kassem Mukhtar A. , Li Heng , Hua Bingqing 
Published: August 2021

AbstractVirtual reality (VR) technology is a kind of computer simulation system that can create and experience the virtual world. It uses computers to generate a simulation environment. It is a system simulation of multisource information fusion, interactive three‐dimensional dynamic view, and physical behavior for users to immerse in the environment. The practical application of virtual instructional models is developed to support civil engineering teaching, disciplines related to civil engineering processes, including classroom education and e‐learning technologies. The virtual model can be interactively operated, allowing the teacher or student to monitor the physical evolution of the work and the progress of architectural activities inherent in it. This paper analyzes the development status of VR and its application in teaching research and describes the application of a VR teaching model to demonstrate the feasibility and advantages of VR teaching. The developed application can display the physical evolution of the task, detect the planned construction sequence, and view the shape details of each construction component. The use of VR technology in developing these instructional applications contributes to education by increasing the efficiency of the models to allow for the interactivity of each simulation task. Therefore, the new concept of VR technology applied in teaching mode brings a new perspective to civil engineering education.
Relationship of established risk factors with breast cancer subtypes
Authors: McCarthy Anne Marie , Friebel‐Klingner Tara , Ehsan Sarah , He Wei , Welch Michaela , Chen Jinbo , Kontos Despina , Domchek Susan M. , Conant Emily F. , Semine Alan , Hughes Kevin , Bardia Aditya , Lehman Constance , Armstrong Katrina 
Published: August 2021

AbstractBackgroundBreast cancer is a heterogeneous disease, divided into subtypes based on the expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). Subtypes have different biology and prognosis, with accumulating evidence of different risk factors. The purpose of this study was to compare breast cancer risk factors across tumor subtypes in a large, diverse mammography population.MethodsWomen aged 40–84 without a history of breast cancer with a screening mammogram at three United States health systems from 2006 to 2015 were included. Risk factor questionnaires were completed at mammogram visit, supplemented by electronic health records. Invasive tumor subtype was defined by immunohistochemistry as ER/PR+HER2−, ER/PR+HER2+, ER, and PR−HER2+, or triple‐negative breast cancer (TNBC). Cox proportional hazards models were run for each subtype. Associations of race, reproductive history, prior breast problems, family history, breast density, and body mass index (BMI) were assessed. The association of tumor subtypes with screen detection and interval cancer was assessed using logistic regression among invasive cases.ResultsThe study population included 198,278 women with a median of 6.5 years of follow‐up (IQR 4.2–9.0 years). There were 4002 invasive cancers, including 3077 (77%) ER/PR+HER2−, 300 (8%) TNBC, 342 (9%) ER/PR+HER2+, and 126 (3%) ER/PR−HER2+ subtype. In multivariate models, Black women had 2.7 times higher risk of TNBC than white women (HR = 2.67, 95% CI 1.99–3.58). Breast density was associated with increased risk of all subtypes. BMI was more strongly associated with ER/PR+HER2− and HER2+ subtypes among postmenopausal women than premenopausal women. Breast density was more strongly associated with ER/PR+HER2− and TNBC among premenopausal than postmenopausal women. TNBC was more likely to be interval cancer than other subtypes.ConclusionsThese results have implications for risk assessment and understanding of the etiology of breast cancer subtypes. More research is needed to determine what factors explain the higher risk of TNBC for Black women.
Mortality associated with the use of non‐vitamin K antagonist oral anticoagulants in cancer patients: Dabigatran versus rivaroxaban
Authors: Lin Yu‐Sheng , Kuan Feng‐Che , Chao Tze‐Fan , Wu Michael , Chen Shao‐Wei , Chen Mien‐Cheng , Chung Chang‐Ming , Chu Pao‐Hsien , Lip Gregory Y. H. , Wu Victor Chien‐Chia 
Published: August 2021

AbstractObjectiveThis study assesses the mortality outcomes of non‐vitamin K antagonist oral anticoagulants (NOACs) in cancer patients with venous thromboembolism (VTE) and atrial fibrillation (AF).MethodsMedical records of cancer patients receiving NOACs for VTE or AF between January 1, 2011, and December 31, 2016, were retrieved from Taiwan's National Health Institute Research Database. NOACs were compared using the inverse probability of treatment weighting (IPTW) method. The primary outcome was cancer‐related death. Secondary outcomes were all‐cause mortality, major bleeding, and gastrointestinal (GI) bleeding.ResultsAmong 202,754 patients who received anticoagulants, 3591 patients (dabigatran: 907; rivaroxaban: 2684) with active cancers were studied. Patients who received dabigatran were associated with lower risks of cancer‐related death at one year (HR = 0.71, 95% CI = 0.54–0.93) and at the end of follow‐ups (HR = 0.79, 95% CI = 0.64–0.98) compared with rivaroxaban. Patients who received dabigatran were also associated with lower risks of all‐cause mortality (HR = 0.81, 95% CI = 0.67–0.97), major bleeding (HR = 0.64, 95% CI = 0.47–0.88), and GI bleeding (HR = 0.57, 95% CI = 0.39–0.84) at the end of follow‐ups compared with rivaroxaban.ConclusionCompared with rivaroxaban, the use of dabigatran may be associated with a lower risk of cancer‐related death and all‐cause mortality.
Teaching during a pandemic: Insights into faculty teaching practices and implications for future improvement
Authors: Crespín‐Trujillo Valerie , Hora Matthew T. 
Published: August 2021

AbstractThe COVID‐19 pandemic disrupted courses at community colleges and forced a transition to emergency remote learning. This article focuses on the impacts of the rapid shift to online teaching on community college instructors and includes recommendations on ways for institutions to support faculty through professional development in curriculum, instruction, and virtual student engagement.
3D model‐guided transcatheter closure of ascending aorta pseudoaneurysm with the novel Amplatzer Trevisio intravascular delivery system
Authors: Cuman Magdalena , Clemente Alberto , Celi Simona , Santoro Giuseppe 
Published: August 2021

AbstractAscending aorta pseudoaneurysm (AAP) is a rare but life‐threatening complication of atherosclerosis, endocarditis, chest trauma, transcatheter or cardio‐thoracic procedures. Since surgical repair is burdened by high morbidity and mortality, percutaneous closure is nowadays considered a valuable cost‐effective therapeutic alternative. Due to unpredictability and complexity of local anatomy, no standardized technique and device are advised. In this setting, 3D printing technology could significantly help in planning trans‐catheter approach. This article reports on a 3D printed model‐guided percutaneous closure of a huge AAP using an Amplatzer Septal Occluder (Abbott, Plymouth MN) implanted by the recently commercialized Amplatzer Trevisio Intravascular Delivery System.
Coronary stent positioning under live IVUS guidance in low contrast percutaneous coronary interventions: The live IVUS stenting technique
Authors: Lichaa Hady 
Published: August 2021

AbstractIn patients with renal insufficiency, advanced techniques have been described to achieve ultra‐low contrast or zero contrast percutaneous coronary interventions (PCI). However, these techniques use intra‐coronary imaging before stent placement to determine adequate landing zones, by correlating them with saved fluoroscopic landmarks. Still, this leaves the operator with a certain degree of uncertainty about the exact lesion coverage, which is checked with post‐stent intra‐coronary imaging. We hereby describe a novel technique which takes away the concern of uncertainty regarding stent‐landing zones and allows for the highest amount of precision in stent positioning, arguably even better than with the use of angiography. This technique involves positioning coronary stents under the live guidance of an intravascular ultrasound (IVUS) catheter which is positioned simultaneously, side by side to a stent. This technique takes advantage of all the benefits of IVUS based PCI without losing the precision in stent positioning when compared to traditional angiography. It simplifies the application of low contrast PCI by the interventional cardiology community, while maintaining the confidence in precise stenting. It has also the potential to decrease the incidence of contrast‐induced nephropathy, hence procedural morbidity, while allowing for optimal long‐term image based PCI outcomes. Obviously, it applies to moderate or larger coronary segments, without significant tortuosity. It also comes at the expense of slightly larger guide catheters, which is compensated for by the use of thin walled sheaths or sheathless catheter systems. Finally, radial access is still applicable depending on radial artery size and available equipment.
First case of four spontaneously conceived successful pregnancies after fertility‐sparing surgery for cervical cancer
Authors: Metzler Julian Matthias , Schaer Gabriel , Imesch Patrick 
Published: August 2021

AbstractCervical cancer represents a particular burden when affecting women in their fertile years. Fertility‐sparing surgery such as trachelectomy can maintain a woman`s childbearing ability. Favorable outcomes are possible, as depicted in this case.
Durable complete response to immunotherapy with anti‐PD‐1 antibody nivolumab in a patient with oral squamous cell carcinoma presenting with lung metastasis: A case report
Authors: Sekido Katsuhisa , Imaue Shuichi , Tomihara Kei , Tachinami Hidetake , Yamagishi Kentaro , Okazawa Seisuke , Ikeda Atsushi , Fujiwara Kumiko , Noguchi Makoto 
Published: August 2021

AbstractAlthough the optimal treatment method for metastatic oral cancer remains largely unknown, the present case suggests that immunotherapy is a potentially promising alternative for metastatic oral cancer in which other therapies are no longer effective.
Guillain‐Barré syndrome after aortic, tricuspid, and mitral valve surgery
Authors: Aldamouk Amer , Saini Harneel , Henn Lucas W. , Marnejon Thomas , Gemmel David J. 
Published: August 2021

AbstractGuillain‐Barré syndrome incidence within 8 weeks of a surgical procedure appears to be more common than previously thought. GBS following open‐heart surgery is exceedingly rare, perhaps underdiagnosed or underreported given surveillance data incidence. Clinicians should be keenly aware of this association and quickly consider a GBS diagnosis.
Lamina cribrosa perforation during nasotracheal intubation in neonates: case series and review of the literature
Authors: Lupi Fiorenzo , Staffler Alex , Parmeggiani Lucio , Klemme Mathias , Dalla Pozza Robert , Stuefer Josef , Thorsteinsdottir Jun , Peraud Aurelia , Flemmer Andreas W. 
Published: August 2021

AbstractIntracranial penetration during attempted nasotracheal intubation is a potentially devastating complication, which should be carefully evaluated and the risk should be addressed in neonatal resuscitation trainings.
Recurrent arteriovenous graft thrombosis in COVID‐19 positive patient
Authors: Singh Anil Kumar , Bansal Saurabh , Singhania Namrata , Singhania Girish 
Published: August 2021

AbstractHypercoagulability is one of the common complications seen in COVID‐19. It can lead to multiple thromboembolic complications. Recurrent arteriovenous graft thrombosis can be one of complications from this pathophysiology.
The unusual case of babesiosis causing disseminated intravascular coagulation with hemophagocytic lymphohistiocytosis
Authors: Goodman Alexandra , Bilal Musa , Amarnath Shivantha , Gentile Teresa , Shepherd Zachary 
Published: August 2021

AbstractBabesiosis is increasing in the elderly due to an age‐related decline in immunity. Prompt diagnosis with blood smear and PCR prevent life‐threatening complications, like DIC and HLH. Studies focusing on pathophysiology and risk factors are needed.
Perioperative management of von Willebrand patients at the time of implant placement: Case report
Authors: Takashima Hiroyuki , Sato (Boku) Aiji , Miyamoro Hironori , Kato Shinichiro , Furuno Shota , Shibuya Yasuyuki 
Published: August 2021

AbstractIn the management of patients with type 1 von Willebrand disease, supplementation with Con Facto F® as well as hemodynamic stabilization with appropriate analgesia and sedation may be important to reduce the risk of bleeding.
Take a “Snapshot” of New Syntheses, Reactions, and Characterizations from Unusual Unsaturated Ring Strained Group 4 Metallacycles
Authors: Rosenthal Uwe 
Published: August 2021

AbstractRecently published syntheses, reactions and characterizations of unusual unsaturated ring strained Group 4 metallocene metallacycles like metalla‐cyclocumulenes, ‐cycloallenes and ‐cycloalkynes with different ring size are updated for the last three years. There exist for some of these metallacycles, depending on the ring size, 7‐, 5‐ and 4‐membered compounds. The new results for these metallacycles are summarized here and considered in addition to the former published results. Additionally, several compounds of this type were now characterized by new reactions. For a better understanding of these compounds, some spectroscopical methods as well as theoretical calculations were published. Despite of these all‐C‐metallacycles, only in some cases the syntheses and reactions for the corresponding hetero‐metallacycles were published too. Examples for these metallaheterocyclic compounds will not be considered in this article. All these unusual ring strained compounds have a great potential for a lot of interesting synthetic applications in the future. Additionally, they are very interesting from the theoretical point of view.
Recent Progress in Metal‐Organic Frameworks@Cellulose Hybrids and Their Applications
Authors: Liu Xiongli , Xiao Yun , Zhang Zhiyuan , You Zifeng , Li Jinli , Ma Dingxuan , Li Baiyan 
Published: August 2021

AbstractIn recent years, metal‐organic frameworks (MOFs) are attracting increasing attention due to their charming properties. However, the intrinsic fragility, powdered crystalline state, and poor processibility of MOFs hinder their further application. By this, the designs of MOF‐based aerogels, hydrogels, membranes are effective ways to solve this problem. Graphene, silica, synthetic polymer and cellulose are the commonly used raw materials for fabricating MOF‐based aerogels, hydrogels, and membranes. Among them, cellulose and its derivatives are the best candidates to support the powdered MOFs from the perspectives of economy, environmental protection and property. This review focuses on discussing the advantages of MOF@cellulose hybrids in applications such as water treatment, antibacterial, gas separation and adsorption, energy storage, drug delivery, catalysis, and other smart composites. MOF@cellulose‐based aerogels, hydrogels and membranes can provide valuable guidance for investigating the practical application of MOFs in terms of processability, reusability, stability and easiness in handling.
Pharmacokinetics, Safety, and Tolerability of the α2C‐Adrenoreceptor Antagonist BAY 1193397 in Healthy Male Subjects
Authors: Kapsa Stefanie , Thuss Uwe , Boxnick Stefanie , Schaumann Frank , Schultz Armin , Unger Sigrun , Otto Christiane 
Published: August 2021

AbstractThe α2C‐adrenoreceptor antagonist BAY 1193397 is in development for the oral treatment of diabetic foot ulcers. Safety, tolerability, and pharmacokinetics of BAY 1193397 were investigated in 3 randomized, single‐center phase 1 studies in healthy male subjects: a first‐in‐human study (single oral doses of 0.5‐50 mg), a relative bioavailability and food effect study (single doses of 1 and 10 mg), and a multiple‐dose escalation study (using 2 and 5 mg twice daily and 10 and 20 mg once daily for 9 consecutive days). BAY 1193397 was rapidly absorbed in the fasted state, peak concentrations were reached between 0.6 and 2 hours. The mean terminal half‐life was in the range of 17 to 20 hours. Area under the plasma concentration–time curve and maximum concentration appeared to be dose proportional, with a negligible food effect. There were no high‐accumulation effects of BAY 1193397 after repeated dosing. BAY 1193397 was safe and well tolerated. At supratherapeutic plasma concentrations, there were slight transient increases in norepinephrine levels, heart rate, and blood pressure that were more pronounced after a single dose compared to steady state and appeared to be maximum concentration dependent. The results of the presented studies support the conduct of subsequent clinical trials with BAY 1193397 in patients with diabetes and compromised microcirculation.
Dissection of two quantitative trait loci for grain length linked on the long arm of chromosome 5 in rice
Authors: Niu Xiaojun , Zhang Zhenhua , Chan Aye Nyein , Fan Yeyang , Tang Shaoqing , Yu Sibin , Zhuang Jieyun , Zhu Yujun 
Published: August 2021

AbstractGrain size is the major determinant of grain weight and has an important role in grain quality. It is controlled by several major quantitative trait loci (QTL) and many minor QTL. Identification of QTL for grain size is important for understanding the genetic and molecular network regulating grain size in rice (Oryza sativa L.). Following previous identification of QTL for grain weight and size using an F2:3 family derived from the indica rice cross Teqing/IRBB52, one QTL, qTGW5, having significant effects on grain length and weight, was targeted for validation, dissection, and fine‐mapping. First, the effect of qTGW5 was validated using two near‐isogenic line (NIL)‐F2 populations. Then, qTGW5 was dissected into two closely linked QTL using four NIL populations. One of them, qGL5.1, having significant effects on grain length, width, and weight, was located within an 1,896.4‐kb region. The other one, qGL5.2, controlling grain length, was further delimited into a 68.8‐kb region using seven NIL‐F2 populations. Six annotated genes were found in the qGL5.2 region, of which five showed nucleotide polymorphisms between the two parental lines. Three of the six annotated genes showed significant expression differences between NILTeqing and NILIRBB52 in young panicles using quantitative real‐time polymerase chain reaction. The results will facilitate cloning the minor QTL and understanding the genetic architecture for grain size in rice.