bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effects of Large-scale Magnetic Fields on the Model for Repeating Changing-look AGNs
Authors: Pan Xin , Li Shuang-Liang , Cao Xinwu 
Published: April 2021

Abstract
Periodic outbursts are observed in several changing-look (CL) active galactic nuclei (AGNs). Sniegowska et al. suggested a model to explain the repeating CL in these AGNs, where the periodic outbursts are triggered in a narrow unstable zone between an inner advection-dominated accretion flow and outer thin disk. In this work, we intend to investigate the effects of large-scale magnetic fields on the limit cycle behaviors of CL AGNs. The winds driven by magnetic fields can significantly change the structure of thin disk by taking away the angular momentum and energy of the disk. It is found that the period of outburst in repeating CL AGNs can be substantially reduced by the magnetic fields. Conversely, if we keep the period unchanged, the outburst intensity can be raised by several times. These results can help to explain the observational properties of multiple CL AGNs. Besides the magnetic fields, the effects of transition radius

, the width of the transition zone ΔR, and the Shakura–Sunyaev parameter α are also explored in this work.
Revisiting Rotation Measures from the Canadian Galactic Plane Survey: the Magnetic Field in the Disk of the Outer Galaxy
Authors: Van Eck C. L. , Brown J. C. , Ordog A. , Kothes R. , Landecker T. L. , Cooper B. , Rae K. M. , Del Rizzo D. A. , Gray A. D. , Ransom R. , Reid R. I , Uyaniker B. 
Published: April 2021

Abstract
Faraday rotation provides a valuable tracer of magnetic fields in the interstellar medium; catalogs of Faraday rotation measures provide key observations for studies of the Galactic magnetic field. We present a new catalog of rotation measures derived from the Canadian Galactic Plane Survey, covering a large region of the Galactic plane spanning 52° < l < 192°, −3° < b < 5°, along with northern and southern latitude extensions around l ≈ 105°. We have derived rotation measures for 2234 sources (4 of which are known pulsars), 75% of which have no previous measurements, over an area of approximately 1300 deg2. These new rotation measures increase the measurement density for this region of the Galactic plane by a factor of 2.
A Nearby Repeating Fast Radio Burst in the Direction of M81
Authors: Bhardwaj M. , Gaensler B. M. , Kaspi V. M. , Landecker T. L. , Mckinven R. , Michilli D. , Pleunis Z. , Tendulkar S. P. , Andersen B. C. , Boyle P. J. , Cassanelli T. , Chawla P. , Cook A. , Dobbs M. , Fonseca E. , Kaczmarek J. , Leung C. , Masui K. , Mnchmeyer M. , Ng C. , Rafiei-Ravandi M. , Scholz P. , Shin K. , Smith K. M. , Stairs I. H. , Zwaniga A. V. 
Published: April 2021

Abstract
We report on the discovery of FRB 20200120E, a repeating fast radio burst (FRB) with a low dispersion measure (DM) detected by the Canadian Hydrogen Intensity Mapping Experiment FRB project. The source DM of 87.82 pc cm−3 is the lowest recorded from an FRB to date, yet it is significantly higher than the maximum expected from the Milky Way interstellar medium in this direction (∼50 pc cm−3). We have detected three bursts and one candidate burst from the source over the period 2020 January–November. The baseband voltage data for the event on 2020 January 20 enabled a sky localization of the source to within ≃14 arcmin2 (90% confidence). The FRB localization is close to M81, a spiral galaxy at a distance of 3.6 Mpc. The FRB appears on the outskirts of M81 (projected offset ∼20 kpc) but well inside its extended H i and thick disks. We empirically estimate the probability of a chance coincidence with M81 to be <10−2. However, we cannot reject a Milky Way halo origin for the FRB. Within the FRB localization region, we find several interesting cataloged M81 sources and a radio point source detected in the Very Large Array Sky Survey. We search for prompt X-ray counterparts in Swift Burst Alert Telescope and Fermi/GBM data, and, for two of the FRB 20200120E bursts, we rule out coincident SGR 1806−20-like X-ray bursts. Due to the proximity of FRB 20200120E, future follow-up for prompt multiwavelength counterparts and subarcsecond localization could be constraining of proposed FRB models.
Tidal Effects on the Radial Velocities of V723 Mon: Additional Evidence for a Dark 3 M
⊙ Companion
Authors: Masuda Kento , Hirano Teruyuki 
Published: April 2021

Abstract
Jayasinghe et al. identified a dark ≈3 M
⊙ companion on a nearly edge-on ≈60 day orbit around the red giant star V723 Monoceros as a black hole candidate in the mass gap. This scenario was shown to explain most of the data presented by Jayasinghe et al., except for periodic radial velocity (RV) residuals from the circular Keplerian model. Here we show that the RV residuals are explained by orbital phase-dependent distortion of the absorption line profile associated with changing visible fractions of the approaching and receding sides of the red giant star, whose surface is tidally deformed by and rotating synchronously with the dark companion. Our RV model constrains the companion mass M
• = 2.95 ± 0.17 M
⊙ and orbital inclination

(medians and 68.3% highest density intervals of the marginal posteriors) adopting the radius of the red giant 24.0 ± 0.9 R
⊙ as constrained from its SED and distance. The analysis provides independent support for the companion mass from ellipsoidal variations and the limits on the companion’s luminosity from the absence of eclipses, both derived by Jayasinghe et al. We also show that a common scheme to evaluate the tidal RV signal as the flux-weighted mean of the surface velocity field can significantly underestimate its amplitude for RVs measured with a cross-correlation technique, and present a modified prescription that directly models the distorted line profile and its effects on the measured RVs. The formulation will be useful for estimating the component masses and inclinations in other similar binaries.
Systemic Sclerosis and Associated Interstitial Lung Disease in Ontario, Canada: An Examination of Prevalence and Survival Over 10 Years
Authors: Pope Janet E. , Quansah Kobina , Hassan Shazia , Seung Soo Jin , Flavin Jason , Kolb Martin 
Published: April 2021

ObjectiveSystemic sclerosis (SSc) is a rare autoimmune disease. Pulmonary complications of SSc are some of the leading causes of morbidity and mortality. The objective of this study was to determine prevalence and survival estimates of SSc and SSc with interstitial lung disease (SSc-ILD) in the Canadian province of Ontario using administrative data over 10 years.MethodsUsing International Classification of Diseases, 10th revision codes adapted for Canada (ICD-10-CA), adult patients diagnosed with SSc and SSc-ILD between April 1, 2008, and March 31, 2018, were identified from the National Ambulatory Care Reporting System and the Discharge Abstract Database administrative databases. SSc was identified first, and ILD was included if presence occurred after SSc diagnosis. Prevalence estimates were determined for both SSc and SSc-ILD. For survival rates, Kaplan-Meier survival curves were generated.ResultsAt the start of the 2017/18 fiscal year (final year of the cohort), there were 2114 prevalent SSc cases for a cumulative prevalence of 19.1 per 100,000 persons, as well as 257 prevalent cases of SSc-ILD that generated a prevalence of 2.3 cases per 100,000 persons. Mean ages were 57 and 58 years with 84% and 80% females for patients with SSc and SSc-ILD, respectively. One-, 5-, and 10-year survival rates were 85.0%, 64.5%, and 44.9% for the SSc group and 77.1%, 44.4%, and 22.0% for the SSc-ILD group, respectively.ConclusionTo our knowledge, this study provides the first population-based estimates of SSc and SSc-ILD in Canada for prevalence and survival. Results confirm that the prevalence estimates of SSc-ILD fall within the Canadian threshold for rare disease. It also demonstrates the poor survival in SSc, especially when ILD is also present.
Treatment With Tofacitinib in Refractory Psoriatic Arthritis: A National Multicenter Study of the First 87 Patients in Clinical Practice
Authors: Galíndez-Agirregoikoa Eva , Prieto-Peña Diana , Martín-Varillas José Luis , Joven Beatriz , Rusinovich Olga , Melero-González Rafael B. , Ortiz-Sanjuan Francisco , Almodóvar Raquel , Alegre-Sancho Juan José , Martínez Ángels , Sellas-Fernández Agustí , Méndez Lara , García-Vicuña Rosario , Atienza-Mateo Belén , Gorostiza Iñigo , González-Gay Miguel Ángel , Blanco Ricardo 
Published: April 2021

Objective.Tofacitinib (TOF) is the first Janus kinase (JAK) inhibitor approved for psoriatic arthritis (PsA). It has shown efficacy in patients refractory to anti–tumor necrosis factor-α in randomized controlled trials (RCTs). Our aim was to assess efficacy and safety of TOF in clinical practice.Methods.This was an observational, open-label multicenter study of PsA patients treated with TOF due to inefficacy or adverse events of previous therapies. Outcome variables were efficacy, corticosteroid dose-sparing effect, retention rate, and safety. A comparative study of clinical features between our cohort of patients and those from the OPAL Beyond trial was performed.Results.There were 87 patients (28 women/59 men), with a mean age of 52.8 ± 11.4 years. All patients were refractory to biologic disease-modifying antirheumatic drugs (DMARDs) and/or to conventional synthetic DMARDs plus apremilast. TOF was started at 5 mg twice daily after a mean follow-up of 12.3 ± 9.3 years from PsA diagnosis. At first month, Disease Activity Score in 28 joints based on erythrocyte sedimentation rate (DAS28-ESR) decreased from median 4.8 (IQR 4.1–5.4) to 3.7 (IQR 2.8–4.7,P< 0.01), Disease Activity Index for Psoriatic Arthritis from median 28 (IQR 18.4–34.1) to 15.5 (IQR 10.1–25.7,P< 0.01), and C-reactive protein from median 1.9 (IQR 0.3–5.0) to 0.5 (IQR 0.1–2.2) mg/dL (P< 0.01). Also, TOF led to a significant reduction in prednisone dose. Mild adverse effects were reported in 21 patients (24.13%), mainly gastrointestinal symptoms. TOF retention rate at Month 6 was 77% (95% CI 65.2–86.3). Patients in clinical practice were older with longer disease duration and received biologic agents more commonly than those in the OPAL Beyond trial.Conclusion.Data from clinical practice confirm that TOF seems to be effective, rapid, and relatively safe in refractory PsA despite clinical differences with patients in RCTs.
Blanding's Turtle Demography and Population Viability
Authors: King Richard B. , Golba Callie K. , Glowacki Gary A. , Kuhns Andrew R. 
Published: April 2021

AbstractIn anticipation of U.S. federal status classification (warranted, warranted but precluded, not warranted), scheduled for 2023, we provide population viability analysis of the Blanding's turtle Emydoidea blandingii, a long-lived, late-maturing, semi-aquatic species of conservation concern throughout its range. We present demographic data from long-term study of a population in northeastern Illinois and use these data as the basis for viability and sensitivity analyses focused on parameter uncertainty and geographic parameter variation. We use population viability analysis to identify population sizes necessary to provide population resiliency to stochastic disturbance events and catastrophes, and demonstrate how alternative definitions of ‘foreseeable future' might affect status decisions. Demographic parameters within our focal population resulted in optimistic population projections (probability of extinction = 0% over 100 y) but results were less optimistic when catastrophes or uncertainty in parameter estimates were incorporated (probability of extinction = 3% and 16%, respectively). Uncertainty in estimates of age-specific mortality had the biggest impact on population viability analysis outcomes but uncertainty in other parameters (age of first reproduction, environmental variation in age-specific mortality, percent of females reproducing, clutch size) also contributed. Blanding's turtle demography varies geographically and incorporating this variation resulted in both mortality- and fecundity-related parameters affecting population viability analysis outcomes. Possibly, compensatory variation among demographic parameters allows for persistence across a wide range of parameter values. We found that extinction risk decreased and retention of genetic diversity increased rapidly with increasing initial population size. In the absence of catastrophes, demographic conservation goals could be met with a smaller initial population size than could genetic conservation goals; ≥20–50 adults were necessary for extinction risk &lt;5%, whereas ≥50–110 adults were necessary to retain &gt;95% of existing genetic diversity over 100 y. These thresholds shifted upward when catastrophes were included; ≥50–200 adults were necessary for extinction risk &lt;5% and ≥110 to &gt;200 adults were necessary to retain &gt;95% of existing genetic diversity over 100 y. Impediments to Blanding's turtle conservation include an incomplete understanding of geographic covariation among demographic parameters, the large amount of effort necessary to estimate and monitor abundance, and uncertainty regarding the impacts of increasingly frequent extreme weather events.
Nœuds. Figures de l’essentiel
Authors: Ossola Carlo 
Published: April 2021

Du Moyen Âge à l’époque moderne, du moins jusqu’à Érasme, la tradition latine repose sur le principe des universels. Au temps de la mondialisation et de la globalisation, ce legs nous invite, plus que jamais, à renouer avec des valeurs fondamentales qui puissent être reconnues par tous et partout – l’universel – et partagées – l’essentiel.

Dans cet ouvrage issu de sa leçon de clôture, Carlo Ossola déroule le fil de ses vingt ans d’enseignement au Collège de France. Mais plus encore, il suggère quelques points à partir desquels notre condition humaine d’abalietas (« abaliété »), constitutive de chacun de nous, peut nous montrer la voie à suivre en lui donnant un sens qui soit véritablement orienté vers autrui.
Le partenariat en éducation relative à l’environnement : pertinence et défis
Authors: Sauvé Lucie 
Published: April 2021

En cette époque de « restructuration » et d’« intégration », le partenariat apparaît souvent comme une stratégie salvatrice dans différents secteurs d’activité humaine. Est-ce dans la foulée de cette tendance contemporaine que le mouvement des réformes éducatives en cours valorise le partenariat entre l’école et les autres acteurs de la « société éducative » ? Quel sens le partenariat prend-il en éducation et plus spécifiquement, dans le domaine de l’éducation relative à l’environnement ? S’agit-il de promouvoir des alliances utilitaires et instrumentales, ou de mettre en place des processus de coopération solidaire favorisant l’apprentissage et le développement mutuel de ses acteurs ? Cet article explore sommairement les caractéristiques, la pertinence et les défis du partenariat en éducation relative à l’environnement. Il propose des critères d’évaluation pour la qualité d’un processus partenarial.
Cognitive Stimulation in an Intensive Care Unit: A Qualitative Evaluation of Barriers to and Facilitators of Implementation
Authors: Parker Ann M. , Aldabain Louay , Akhlaghi Narges , Glover Mary , Yost Stephanie , Velaetis Michael , Lavezza Annette , Mantheiy Earl , Albert Kelsey , Needham Dale M. 
Published: April 2021

Background
Delirium in the intensive care unit is associated with poor patient outcomes. Recent studies support nonpharmacological therapy, including cognitive stimulation, to address delirium. Understanding barriers to cognitive stimulation implemented by nurses during clinical care is essential to translating evidence into practice.

Objective
To use qualitative methods through a structured quality improvement project to understand nurses’ perceived barriers to implementing a cognitive stimulation intervention in a medical intensive care unit.

Methods
Data were collected through semistructured interviews with nurses in a medical intensive care unit. Data were categorized into themes by using thematic analysis and the Consolidated Framework for Implementation Research. During cognitive stimulation, nurses reviewed with patients a workbook of evidence-based tasks (focused on math, alertness, motor skills, visual perception, memory, problem-solving, and language).

Results
The 23 nurses identified 62 barriers to and 26 facilitators of cognitive stimulation. These data were summarized into 12 barrier and 9 facilitator themes corresponding to the following Consolidated Framework for Implementation Research domains: Intervention Characteristics, Outer Setting, Inner Setting, and Characteristics of Individuals. Nurses also identified several facilitators within the Process domain. Patient-specific variables, including sedation, were the most frequently reported barriers. Other barriers included cognitive stimulation not being prioritized, nursing staff–related issues, documentation burden, and a lack of understanding of, or appreciation for, the evidence supporting cognitive stimulation.

Conclusions
Implementation of cognitive stimulation requires a multidisciplinary approach to address perceived barriers arising from the organization, context, and individuals associated with the intervention, as well as the intervention itself.
Pain Associated With Continuous Intravenous Infusion of Bumetanide: A Case Series
Authors: Herges Lori B. , Jentzer Jacob C. , Brighton Diane D. , Herges Joseph R. , Ou Narith N. 
Published: April 2021

Introduction
Bumetanide can induce generalized musculoskeletal pain when administered as a continuous infusion, an effect that may be underrecognized. The purpose of this case series is to educate health care providers about the incidence and presentation of pain associated with bumetanide infusions, adding to the existing literature describing this adverse event.

Clinical Findings
Of 40 critically ill patients, 15 (38%) had increased pain scores after initiation of a continuous infusion of bumetanide, with symptoms commonly occurring 12 to 24 hours after initiation of the infusion. Reported descriptions of the pain included generalized aching, soreness, burning, allodynia, headaches, and exacerbation of underlying pain in localized areas. Increases in patient-reported pain correlated directly with initiation of the continuous infusion of bumetanide.

Diagnosis
Four of the 15 bumetanide-associated pain events (27%) were recognized as such by the health care team.

Interventions
Bumetanide was promptly discontinued in the 4 identified cases. The 11 patients (73%) whose pain was not recognized as related to bumetanide remained on a continuous infusion of bumetanide and received pain medications including opioids. Infusions were stopped when patients transitioned to dialysis (n = 8 [53%]), began receiving comfort care (n = 5 [33%]), or completed diuresis therapy (n = 2 [13%]).

Outcomes
For all patients, pain symptoms resolved within 24 to 48 hours after discontinuation of bumetanide infusion with no significant electrolyte abnormalities.

Conclusion
Bumetanide-induced pain is more common than previously described. Early recognition of this adverse event can prevent patient discomfort and escalation of treatment.
A Bundle-Based Approach to Prevent Catheter-Associated Urinary Tract Infections in the Intensive Care Unit
Authors: Shadle Holly N. , Sabol Valerie , Smith Amanda , Stafford Heather , Thompson Julie A. , Bowers Margaret 
Published: April 2021

Background
Catheter-associated urinary tract infections are the second most common health care–associated infections, occurring most frequently in intensive care units. These infections negatively affect patient outcomes and health care costs.

Local Problem
The targeted institution for this improvement project reported 13 catheter-associated urinary tract infections in 2018, exceeding the hospital’s benchmark of 4 or fewer such events annually. Six of the events occurred in the intensive care unit. Project objectives included a 30% reduction in reported catheter-associated urinary tract infections, 20% reduction in urinary catheter days, and 75% compliance rating in catheter-related documentation in the intensive care unit during the intervention phase.

Methods
This project used a pre-post design over 2 consecutive 4-month periods. The targeted population was critically ill patients aged 18 and older who were admitted to the intensive care unit. A set of bundled interventions was implemented, including staff education, an electronic daily checklist, and a nurse-driven removal protocol for indwelling urinary catheters. Data were analyzed using mixed statistics, including independent samples t tests and Fisher exact tests.

Results
No catheter-associated urinary tract infections were reported during the intervention period, reducing the rate by 1.33 per 1000 catheter days. There was a 10.5% increase in catheter days, which was not statistically significant (P = .12). Documentation compliance increased significantly from 50.0% before to 83.3% during the intervention (P = .01).

Conclusions
This bundled approach shows promise for reducing catheter-associated urinary tract infections in critical care settings. The concept could be adapted for other health care–associated infections.
Are women safe in disaster? Competency in handling gender-based violence by public health staff in Galle district
Authors: De Silva E. P. M. , Ponnamperuma T. T. 
Published: April 2021

Introduction: Gender-based violence (GBV) is a human right issue that is common but under reported. It is noted that GBV incidence increases in disaster situations. As the public health staff is the key responsible personnel in post-disaster health management, their competencies in managing GBV in crisis situation are extremely important. Methods: A descriptive cross-sectional study was conducted in conveniently selected 8 Medical Officer of Health (MOH) areas in Galle district. All four categories of public health workers (medical officers, nursing sisters, public health inspectors and midwives) working at selected MOH offices were assessed by a selfadministrated questionnaire regarding knowledge on identification, prevention and management of GBV victims in disaster situations. Results: Among 200 public health workers, only 23.5% had training on disaster management. Among the trained MOH staff, only 34.0% were taught on handing GBV in disaster situation. Knowledge on GBV was average in the staff (mean = 72.3, SD = 7.7). There was no significant difference observed in identification, prevention and management of GBV between different employment categories of the MOH staff (all ps > 0.05). Knowledge on GBV showed no difference between the trained and untrained staff (t (198,200) = 0.8, p = 0.4) on disaster management. Conclusions and Recommendations: Knowledge on identification, prevention and management of GBV in disaster situations among the public health staff was average, and was not sufficient. Only a minority have obtained training and all these programmes have not addressed GBV management. Thus, it is recommended to hold regular training programmes to the public health staff in GBV management in disaster situations.