bluuebunny/crossref_metadata_2025_split huggingface dataset:
Percutaneous Transhepatic Flexible Ureteroscope-Guided Frequency-Doubled Dual&nbsp;Pulse ND:YAG Laser Lithotripsy for Refractory Choledocholithiasis
Authors: Wang Wei , Wang Wujie , Jia Yunming , Chen Chao , Tian Shilin , Shao Chunchun , Wang Yongzheng , Li Yuliang 
Published: February 2021

Abstract
ObjectivesTo evaluate the safety and efficiency of percutaneous transhepatic flexible ureteroscope-guided frequency-doubled dual pulse ND:YAG laser lithotripsy (PTFU-FREDDY) for refractory choledocholithiasis.MethodsFrom December 2017 to October 2018, 24 refractory choledocholithiasis patients with large common bile duct stones, anatomic variations, multiple stones or stones at difficult locations (impacted, above a biliary stricture) were admitted to two centers. Four patients were considered intolerant to surgery or endoscopic retrograde cholangiopancreatography (ERCP), and 2 had ERCP failure, the others refused. All patients underwent PTFU-FREDDY. Clinical success rate, recurrence of calculus, laser safety, and related complications, such as fever, haematoma, and local thermal damage were recorded. ResultsPatients’ mean age was 66.0±12.1 (43-89) years. Sex ratio was 1:1.2 (male: female). The mean diameter of stones was 21.8±2.4 mm. All stones were successfully broken and pushed into the duodenum. The mean lithotripsy frequency and procedure time of Bilirubin stones was higher than cholesterol stones, and the mixed were in middle，P<0.01. One patient（4.2%）had haemobilia, requiring immediate transarterial embolisation with 100mg 300-500um gelatin sponge particles. No pancreatitis, sepsis, or serious local thermal damage, such as bile duct perforation, was observed. The rates of Grade A/B of fever, abdominal pain, nausea, and vomiting were 12.5%, 12.5%, 8.3%, and 4.2% during follow-up, respectively. The recurrence was none at the endpoint of 12 months.Conclusion PTFU-FREDDY is a safe and effective alternative treatment for refractory choledocholithiasis, especially when traditional treatments fail or are difficult to perform.
A simple pressure-assisted method for MicroED specimen preparation
Authors: Zhao Jingjing , Xu Hongyi , Lebrette Hugo , Carroni Marta , Taberman Helena , Högbom Martin , Zou Xiaodong 
Published: February 2021

Abstract
Micro-crystal electron diffraction (MicroED) has shown great potential for structure determination of macromolecular crystals too small for X-ray diffraction. However, specimen preparation remains a major bottleneck. Here, we report a simple method for preparing MicroED specimens, named Preassis, in which excess liquid is removed through an EM grid with the assistance of pressure. We show the ice thicknesses can be controlled by tuning the pressure in combination with EM grids with appropriate hole sizes. Importantly, Preassis can handle a wide range of protein crystals grown in various buffer conditions including those with high viscosity, as well as samples with low crystal contents. Preassis is a simple and universal method for MicroED specimen preparation, and will significantly broaden the applications of MicroED.
Assessment of the subclinical myocardial dysfunction with preserved left ventricle ejection fraction in type 2 diabetes mellitus patients with global myocardial work
Authors: Wang Tao , Huang Jun , Yan Zi-ning , Fan Li 
Published: February 2021

Abstract
To assess the subclinical left ventricle(LV) myocardial dysfunction in preserved left ventricle ejection fraction(LVEF) in type 2 diabetes mellitus(T2DM) patients by global myocardial work(MW). 60 untreated T2DM patients and 60 normal controls were enrolled for this study. Apical 4-, 3- and 2- chamber views were acquired by two-dimensional echocardiography. Peak systolic myocardial layer-specific global longitudinal strain(GLS), peak strain dispersion(PSD), global myocardial work index(GWI), global constructive work(GCW), global wasted work(GWW), and myocardial work efficiency(GWE) were generated by speckle-tracking echocardiography(STE). The values of GLS in T2DM patients were significantly lower than normal controls(p < 0.05). GWW in T2DM patients was significantly larger than normal controls, while GWE was significantly lower(p < 0.05). In T2DM patients, fasting plasma glucose positively correlated with GWW, while negatively correlated with GWE, respectively. ROC analysis showed GWE was superior to other values with a highest AUC of 0.688. Logistic regression analysis indicated that GLSEndo (OR = 1.196, 95% CI: 1.012–1.414, p = 0.036), and GWE (OR = 0.585, 95% CI: 0.414–0.825, p = 0.002) were independent risk factors associated with LV function in T2DM patients. From the research, the subclinical LV myocardial dysfunction was detected by GLS and global MW in T2DM patients. Global MW is a sensitive predictor to demonstrate the subclinical LV myocardial dysfunction in T2DM patients.
Effect of Benzophenone-3&nbsp;to Acetylcholinesterase and&nbsp;Antioxidant System&nbsp;in Zebrafish (Danio Rerio)&nbsp;Embryos&nbsp;
Authors: Sandoval-Gío Juan José , Noreña-Barroso Elsa , Escalante-Herrera Karla , Rodriguez-Fuentes Gabriela 
Published: February 2021

Abstract
Benzophenone-3 (BP-3) is one of the most used UV filters. This study aimed to evaluate the toxic effects of BP-3 during embryo stages of zebrafish, four hours post-fertilization (4hpf). Embryos were exposed to 0, 1, and 10 µg L-1 of BP-3, for 72 hours. We investigated biochemical and molecular biomarkers of neurotoxicity (AChE) and the antioxidant system (gene expression of catalase, CAT, superoxide dismutase, SOD, glutathione peroxidase, GPX, the concentration of total glutathione, GSH, and lipid hydroperoxides, LPO). Results indicated that the acute exposure to BP-3 in zebrafish embryos did not show significant differences in survival, hatching rate, or in the biomarkers of antioxidant system. In contrast, there were significant differences associated with AChE gene expression and activity.
Research on Gradient Additive Remanufacturing of Ultra-large Hot Forging Die Based on Automatic Wire Arc Additive Manufacturing Technology
Authors: Hong Xiaoying , Xiao Guiqian , Zhang Yancheng , Zhou Jie 
Published: February 2021

Abstract
In this paper, an automatic WAAM technology are proposed to realize the gradient additive remanufacturing of ultra-large hot forging dies. Firstly, a vertical additive manufacturing strategy and a normal additive manufacturing strategy are proposed to meet different additive manufacturing demands. Secondly, the basic principle of layering design of ultra-large hot forging dies is developed, and the wear resistance of Ni-based, Co-based and Fe-based alloys at room temperature and high temperature is analyzed. The Co-based alloy has the best high temperature wear resistance, which can be used on the surface of the hot forging die to strengthen the die. In order to control the forming quality of additive manufacturing, the relationship between welding parameters and weld shape was discussed, and the reverse system of welding process parameters was built. Finally, a typical aviation ultra-large hot forging die is selected as the research object. According to different stress and temperature distribution in different regions of the ultra-large hot forging die in service, materials with different properties are used in corresponding regions to improve the service life of the die, reduce the remanufacturing costs and improve the remanufacturing efficiency. The experimental results show that the service life of the hot forging die repaired by the automatic gradient function WAAM technology is significantly increased, the material is reduced by more than 50% and the production efficiency is increased by more than 50%.
The role of radiotherapy and chemotherapy in adult optic nerve gliomas: a SEER-based analysis
Authors: Huang Rong , Huang Yanlin , Su Jinyun , Li Heng , Liu Zhong , Tian Xinhua , Lin Xiaoning 
Published: February 2021

Abstract
PurposeOptic nerve gliomas (ONGs) are uncommon tumors of the central nervous system in adults. The aim of this study was to define their characteristics, prognostic factors, and the impacts of adjuvant radiotherapy (RT) and chemotherapy on outcomes.MethodsAdult patients (age ≥ 18 years) with ONGs from the Surveillance, Epidemiology, and End Results (SEER) database were included. Univariate and multivariate Cox regression models were utilized to analyze the factors associated with survival. Kaplan-Meier method was used to evaluate the impacts of adjuvant therapies on overall survival (OS).ResultsA total of 179 adult patients diagnosed with ONGs were identified between 1991 and 2016, with a median follow-up period of 64.0 months. The median age at diagnosis was 41.0 years. After excluding 18 patients with unknown information, the remaining patients included 142 (88.2%) low-grade tumors and 19 (11.8%) high-grade tumors. Multivariate analysis showed age at diagnosis, tumor grade, adjuvant chemotherapy were significant factors for OS. The 5-year OS rates for patients with low- and high-grade ONGs were 85.5% and 10.5%, respectively. The employment of adjuvant RT or chemotherapy would significantly shorten OS time in the low-grade group and could not prolong OS time in the high-grade group.ConclusionsThis is the largest retrospective study of adult ONGs up to date. The overall prognosis of high-grade ONGs in adult patients is still poor despite multi-modality treatments. Adjuvant RT or chemotherapy might not be considered in adult patients with low-grade ONGs unless the malignant transformation or aggressive progression has been confirmed.
Visualizing the drivers of an effective health workforce: A detailed, interactive logic model
Authors: Sonderegger Serena , Bennett Sara , Sri Veena , Lalani Ummekulsoom , Hariyani Shreya , Roberton Tim 
Published: February 2021

Abstract
Background
A strong health workforce is a key building block of a well-functioning health system. To achieve health systems goals, policymakers need information on what works to improve and sustain health workforce performance. Most frameworks on health workforce planning and policymaking are high-level and conceptual, and do not provide a structure for synthesizing the growing body of empirical literature on the effectiveness of strategies to strengthen human resources for health (HRH). Our aim is to create a detailed, interactive logic model to map HRH evidence and inform policy development and decision-making.
Methods
We reviewed existing conceptual frameworks and models on health workforce planning and policymaking. We included frameworks that were: (1) visual, (2) comprehensive (not concentrated on specific outcomes or strategies), and (3) designed to support decision-making. We compared and synthesized the frameworks to develop a detailed logic model and interactive evidence visualization tool.
Results
Ten frameworks met our inclusion criteria. The resulting logic model allows for visualization of high-level linkages as well as a detailed understanding of the factors that affect health workforce outcomes. HRH data and governance systems interact with the context to affect how human resource policies are formulated and implemented. These policies affect HRH processes and strategies that influence health workforce outcomes and contribute to the overarching health systems goals of clinical quality, responsiveness, efficiency, and coverage. Unlike existing conceptual frameworks, this logic model has been operationalized in a highly visual, interactive platform that can be used to map the research informing policies and illuminating their underlying mechanisms.
Conclusions
The interactive logic model presented in this paper will allow for comprehensive mapping of literature around effective strategies to strengthen HRH. It can aid researchers in communicating with policymakers about the evidence behind policy questions, thus supporting the translation of evidence to policy.
A systematic literature review of pharmacists in general practice in supporting the implementation of shared care agreements (SCA) in primary care
Authors: Iqbal Naveed , Huynh Chi , Maidment Ian 
Published: February 2021

Abstract
Background Rising demand for healthcare continues to impact on all sectors of the health service. As a result of the growing ageing population and the burden of chronic disease, healthcare has become more complex, the need for more efficient management of specialist medication across the healthcare interface is of paramount importance. With the rising number of pharmacists working in primary care in clinical roles, is this a role that pharmacist could support to ensure the successful execution of Shared Care Agreement (SCA) in primary care for these patients?Aim of the review Systematic review to identify activities and assess interventions provided by pharmacists in primary care on SCA provision and how it affects health-related quality of life (HRQoL) for patients.MethodThe following electronic databases were systematically searched from the date on inception to January 2020: AMED®, CINAHL®, Cochrane Database of Systematic Reviews (CDSR), EMBASE®, EMCARE®, Google Scholar, HMIC®, MEDLINE®, PsycINFO®, Scopus, Web of Science® and grey literature sources were also searched. The search was adapted according to the respective database-specific search tools. It was searched using a combination of medical subject heading terms (MeSH), free-text search terms and Boolean operators.ResultsA total of 6,489 titles/abstracts were screened, and 59 full articles were assessed for eligibility. On examination of full text, no studies met the inclusion criteria for this reviewConclusionThis review highlights the need for further research to evaluate how pharmacists in general practice can support the safe and effective integration of specialist medication in primary care with the use of SCA.
Research on Ultrasonic-Assisted CNC Cutting of Honeycomb Cores Based on UG
Authors: Mu Dongfang , Hu Xiaoping , Yu Haofeng , Yu Baohua 
Published: February 2021

Abstract
Compared with traditional milling, ultrasonic-assisted cutting of honeycomb cores has the advantages of good surface quality and low cutting force. Because the ultrasonic cutter and chip shapes used in ultrasonic machining are significantly different from traditional machining methods. This study is based on UG CAM for process planning, which will be converted into codes that can be recognized by six-axis CNC machine tools through post-processing, and verify the feasibility through VERICUT simulation.
Synthesize and Thermal Treatment of PdCr@carbon&nbsp;for Efficient Oxygen Reduction Reaction in Proton-exchange Membrane Fuel Cells&nbsp;
Authors: Mebed Abdelazim M. , Zeid E. F. Abo , Abd-Elnaiem Alaa 
Published: February 2021

Abstract
A nanostructured PdCr@carbon catalyst is deposited on a supported carbon surface using the modified polyol reduction method for the oxygen reduction reaction (ORR) for the application in the proton exchange membrane fuel cell. The crystal structure and feature nanostructure of the PdCr@carbon were established using the XRD and TEM, while their catalytic activity was studied using the cyclic voltammetry and electrochemical polarization techniques. The estimated average crystallite size of PdCr is increased with the calcination temperature from 9.66 to 37.54 nm as the calcination temperature increased to 973 K, while the annealing time slightly affects the crystallite size. The TEM examination reveals the uniform distribution of the PdCr nanoparticles upon the carbon surface. The calcination temperature and time play an important factor in controlling the structural and morphology parameters of PdCr@carbon and the optimum activity and chemical stability were observed for samples calcined at 573 K for 3 h.
Numerical simulation of magma intrusion on the thermal evolution of low rank coal
Authors: Jiang Jingyu , Zhao Ke , Cheng Yuanping , Zheng Shaojie , Zhang Shuo , Wang Ran 
Published: February 2021

Abstract
To study the effect of magma intrusion on the thermal evolution of low-rank coal with high water content, the mathematical relationship between water content variation and thermal conductivity of low-rank coal was analyzed by COMSOL Multiphysics numerical simulation and field validation. Taking Daxing Mine in Tiefa coalfield as the research background, the effects of magma finite time intrusion mechanism and water volatilization in coal on thermal evolution and organic maturity of coal seam are investigated in this paper. The results show that as the sill thickness increases, the thermal evolution temperature of the coal seam increases, the required thermal evolution time increases and the final retention temperature increases after the coal seam is cooled down. Approaching the magma, the maximum temperature that the coal seam can reach increases, the maximum temperature lasts longer, and the final temperature retained by the coal seam becomes higher. The increase of water content of coal makes the thermal conductivity increase, and the rate of heat transfer from coal seam is accelerated, and more heat is transferred to distant places in the same time. At the same time, the heat lost by the magma in the same time increases, the time required for the cooling of the magma decreases, and the maximum temperature reached by the underlying coal seam is significantly lower. The presence of moisture weakens the thermal evolution of the magma to the coal seam and reduces the expected maturity of the coal. The results of average random vitrinite reflectance (Ro) and moisture examination of coal samples collected at the Daxing Mine site verified the numerical simulation results of magma thermal evolution.
Effects of non-thermal plasma treatment on the geopolymerization of kaolin clay
Authors: SOP-TAMO Berthelot , TARKWA Jean Baptiste , Alomayri Thamer , ASSAEDI HASAN , MOGO Jean Paul KAMSEU , Baenla Jean , KAMGANG-YOUBI Georges , Noumbissié Leonel Tchadjié 
Published: February 2021

Abstract
Cameroonian kaolin samples were used to produce geopolymer cements. Prior to its application, the raw kaolin samples were activated trough the gliding arc plasma treatment in both spatial post-discharge and direct mode. A mixture of sodium hydroxide and silicate was used as the alkaline solution. The materials produced were tested by X-ray diffraction, thermogravimetric analysis, differential scanning calorimeter and Fourier transform infrared spectroscopy in order to study the influence of the modifications generated by the gliding arc plasma treatment on the geopolymerization process. The scanning electron microscopy analyses, nitrogen physisorption analyses and compression tests were also carried out on the materials produced for assessing and understanding their mechanical performance. The results showed that the geopolymerization process remained partial at the curing temperature of 90 °C. Plasma spatial post-discharge mode treated kaolin led to 20.48% increase in compressive strength when compared with the geopolymer prepared from raw kaolin.
An edge-cloud collaborative computing platform for building AIoT applications efficiently
Authors: Rong Guoping , Xu Yangchen , Tong Xinxin , Fan Haojun 
Published: February 2021

Abstract
The convergence of the Artificial Intelligence (AI) and the Internet of Things (IoT), i.e. the Artificial Intelligence of Things (AIoT), is a very promising technology that redefines the way people interact with the surrounding devices. Practical AIoT applications not only have high demands on computing and storage resources, but also desire for high responsiveness. Traditional cloud-based computing paradigm faces the great pressure on the network bandwidth and communication latency, hence the newly emerged edge computing paradigm gets involved. Consequently, AIoT applications can be implemented in an edge-cloud collaborative manner, where the model building and model inferencing are offloaded to the cloud and the edge, respectively. However, developers still face challenges building AIoT applications in practice due to the inherent heterogeneity of the IoT devices, the declining accuracy of once trained models, the security and privacy issues, etc. In this paper, we present the design of an industrial edge-cloud collaborative computing platform that aims to facilitate building AIoT applications in practice. Furthermore, a real-world use case is presented in this paper, which proved the efficiency of building an AIoT application on the platform.
Realization of Visible Light Integrated Circuits for All-Optical Haar Transform
Authors: Fashi Ali Azimi , Samiei Mohammad Hashem Vadjed , Teixeira Antonio 
Published: February 2021

Abstract
Photonic integrated circuits have been designed, simulated and tested on TriPleXTM platform technology for implementing optical Haar Transform (HT) in the visible spectrum. Optical circuits contain the new building block (BB) designed using the multimode interference (MMI) structure performing optical HT on a pair of the optical signals. The Outputs of the BB demonstrates the sum and subtraction of the input signals according to the HT operation. 1st-order and 2nd-order optical HT achieved for the green light input signals. Simulation and experimental results have successfully validated designed photonic circuits capability in implementing optical HT.
Enhanced the light absorptance of stain-etched black Silicon decorated by TiN nanoparticles
Authors: Wang Kaiqiang , Liu Shuang , Li Jiacheng , Wu Shenglan , Xia Jiankai , Chen Jinping , Tian Chunhui , Liu Yong , Zhong Zhiyong 
Published: February 2021

Abstract
Due to the high energy, narrow distribution and breaking through the absorption limitation, plasmon induced hot electrons has been widely applied to extend the photoresponse spectra of the semiconductor. In order to further enhance the resonance effect of local plasmon based on metallic nanostructures, we used hydrofluoric stain etching method to fabricate nanostructured black silicon (BSi) and deposited titanium nitride (TiN) nanoparticles on its surface by reactive magnetron-sputtering. The results show that the BSi modified by plasmonic TiN nanoparticles has higher absorption in wavelength range from 1100 to 2500 nm compared to that of conventional acid etching of BSi. A PIN photoelectronic detector fabricated by the proposed BSi shows excellent device performance with responsivity of 0.45A/W at 1060 nm in near infrared band.