bluuebunny/crossref_metadata_2025_split huggingface dataset:
An empirical analysis of the moderating effect of consumer skepticism between social value orientations and green advertising effectiveness
Authors: Ali Muhammad , Hassan Umar , Mustapha Ishamuddin , Osman Sharina 
Published: July 2021

Purpose
The purpose of this study is to add a reliable factor that can contribute theoretically and methodologically to explain prosocial and proself behaviors. The study also signifies that green advertising approaches enable the consumer to develop an intention for green purchases. The basic idea is to investigate consumer social orientations and align them with green advertising initiatives to elicit the desired response as green purchase to manifest environmentally conscious behavior.

Design/methodology/approach
The empirical analysis is based on data collection through questionnaires. Data is analyzed through structural equation modeling to assess the relationship of constructs.

Findings
The results of the study are empirically drawn through the measurement of relationships among consumer skepticism and the effectiveness of green advertising initiatives. Mediation of proself and prosocial orientation exists for public self-awareness but does not exist for benefit distance. Consumer skepticism moderates the relationship between prosocial orientation and green advertising effectiveness (GAE) but has no moderation between proself orientation and GAE.

Originality/value
The limitation of conventional prosocial theory does not explain the environmental behaviors driven by proself orientations. Hence, the addition of factors such as public awareness and social benefit distance coupled with signaling theory with foundations on theory of planned behavior and norm activation model to explain environmental conservation add an element of originality to the existing literature.

Contribution to Impact
The contribution of this study is the incorporation of social orientations as the antecedent for consumer behavior in an environmental context particularly as a response to green advertising initiatives to purchase green products. The use of theory of planned behavior in conjunction with the norm activation model and signaling theory adds to the literary bank.
Stock option, contract elements design and corporate innovation output – an analyse based on risk-taking and performance-based incentives
Authors: Shi Qi , Xiao Shufang , Chang Kaiwen , Wu Jiaying 
Published: July 2021

PurposeWith the accelerated technological advancement, innovation has become a critical factor, which affects the core competitiveness of a company. However, studies about the relationship between internal stock option mechanisms and innovation productivity remain limited. Therefore, this paper aims to examine the impact of stock options and their elements design on innovation output from an internal mechanism perspective.Design/methodology/approachUsing a sample of 302 stock option incentive plans announced and implemented between 2006 and 2016, this study uses the propensity score matching and difference-in-difference model to find out whether the implementation of stock options improves the innovation outputs of enterprises.FindingsBased on the statistical analysis, it is concluded that: stock options can stimulate corporate innovation; a stock option may drive innovation outputs through two ways, performance-based incentives and risk-taking incentives, with the latter one playing a more dominant role and the risk-taking incentives of stock options, could be optimised when the non-executives granting proportion is larger, the granting range is limited, the incentive period is longer, the exercisable proportion is increasing, the price-to-strike ratio is lower and relatively loose performance assessment criteria are applied.Originality/valueThe conclusion reached in the study may provide valuable information to listed firms in designing and implementing the stock option plans.
The impact knowledge management processes on business performance via the role of accounting information quality as a mediating factor
Authors: Al-Dmour Ahmed , Zaidan Hala , Al Natour Abdul Rahman 
Published: July 2021

PurposeThis study aims to empirically investigate the role of accounting information quality (AIQ) as a mediating factor in the relationship between knowledge management (KM) processes and business performance (BP) of the financial institutions (FI) operating in Jordan.Design/methodology/approachBased on a literature review and knowledge-based theory, an integrated conceptual framework has been developed to guide the study. The study’s conceptual framework is constituted of three primary constructs, namely, KM processes (acquisition, integration and utilization), BP (financial indicators and non-financial indicators) and AIQ conceptualized using the International Accounting Standard Board’s (2010) framework fundamental qualitative characteristics (relevance, understandability, faith representation and comparability). Data has been collected through a self-administered questionnaire applied to 247 respondents. The targeted respondents have been FIs (commercial banks and insurance companies) in Jordan.FindingsThe main findings supported accounting information as a mediator factor in enhancing the relationship between the FIs’ KM process and BP (FI) operating in Jordan.Originality/valueThis study contributed to theory by filling a gap in the literature regarding the role AIQ as a mediator factor between the KM process and BP of the FI operating in Jordan as a developing country.
Age‐at‐death estimation in adults using three forensic methodologies: A Lamendin’s technique approach for Latin American context and the extension of a forensic international dental database
Authors: Garizoain Gonzalo , Parra Roberto C. , Escalante‐Flórez Karen J. , Aranda Claudia M. , Luna Leandro H. , Condori Lucio A. , Valderrama‐Leal Clara I. , Retana‐Milán Fernando 
Published: July 2021

AbstractIn forensic science, the information that teeth provide to the age estimation process is very important. In adults, one of the most widely used indicators of skeletal age is the Root Dentin Translucency (RDT), mainly through the Lamendin technique, which is used in various Latin American contexts. Recently, Parra et al. (2020) have developed a Bayesian regression model using the Lamendin technique to establish standardized criteria for estimating age‐at‐death in adults in various forensic contexts. In this study, we evaluate the applicability of this proposal together with the proposal by Lamendin et al. (1992) and Prince and Ubelaker (2002) in Latin American contexts. A sample of single‐rooted teeth belonging to 805 individuals from six Latin American countries was used. The results of the three proposals considered were analyzed taking into account factors such as age, sex, origin, and the tooth surface on which the variables were surveyed. Of the factors that would affect the estimates, it was found that the age of the individuals had the greatest influence. However, it was confirmed that the sex and surface of the teeth on which the measurements were taken did not influence the final result. On the other hand, as we expected, the application of the analyzed proposals would also be possible in other forensic contexts, as shown by the results obtained according to the origin. This research expands the FIDB with more information on Latino contexts.
Efficacy and safety profile of combining programmed cell death‐1 (PD‐1) inhibitors and antiangiogenic targeting agents as subsequent therapy for advanced or metastatic non‐small cell lung cancer (NSCLC)
Authors: Xu Ziyi , Li Teng , Hu Xingsheng , Hao Xuezhi , Xing Puyuan , Li Junling 
Published: July 2021

AbstractBackgroundPrevious studies have demonstrated that PD‐1 inhibitors are effective in the treatment of advanced or metastatic non‐small cell lung cancer (NSCLC). However, whether the combination of PD‐1 inhibitors and antiangiogenic agents benefit advanced NSCLC patients as subsequent therapy remains unknown. In this study, we retrospectively reviewed the efficacy and safety profile of this combination strategy as subsequent therapy for NSCLC patients in a real‐world setting.MethodsA total of 30 patients with advanced NSCLC, who progressed after at least two cycles of platinum‐based chemotherapy or targeted therapy and subsequently received combination therapy with a PD‐1 inhibitor and antiangiogenic agent, were included in this study. The safety profile and efficacy were also investigated.ResultsAt the time of a median follow‐up period of 10.7 months, 28 patients had experienced progression of disease and 16 patients had died. The median progression‐free survial (mPFS) was 5.0 months (95% confidence interval [CI]: 3.179–6.821), and the median overall survival (mOS) was 14.3 months (95% CI: 8.912–19.659). The objective response rate (ORR) and the disease control rate (DCR) were 10.3% and 72.4%, respectively (0 complete remission, three partial responses and 18 stable disease in 29 patients with measurable lesions). Patients with PD‐L1 expression of at least 1% of tumor cells (n = 5) had relatively longer mPFS compared to those with PD‐L1‐negative tumors (n = 14), (11.6 months vs. 3.7 months). Treatment was suspended in two patients due to grade 3 immune‐related pneumonia and pancreatitis, respectively. No novel adverse events (AEs) or grade 4 AEs were observed.ConclusionsA combination of PD‐1 inhibitors and antiangiogenic targeting agents may be beneficial for patients with advanced or metastatic NSCLC as subsequent treatment, especially for patients with PD‐L1 protein expression positive, and treatment is well tolerated.
Voluntary Disclosure in Light of Control Concerns*
Authors: Arya Anil , Ramanan Ram N.V. 
Published: July 2021

ABSTRACTThe centrality of private information in the design of accounting institutions has been explored via agency models that address control concerns as well as disclosure models that amplify valuation issues. This paper derives disclosures by an entrepreneur‐owner when both control and valuation concerns are in play. In particular, the disclosures influence stock price not only via a direct impact on valuation of the firm's revenue but also via an indirect impact on the firm's cost of procuring inputs from a self‐interested and privately informed upstream supplier. In this setting, disclosures are judiciously designed to influence the supplier's decision to share cost information and to control information rents embedded in the procurement contract within the supply chain. Specifically, in order to convey that information rents are not in the offing and, thus, motivate information sharing by the supplier, the owner has incentives to convey a less “rosy” picture. In effect, when controlling supplier actions also becomes important, the owner discloses some unfavorable revenue news that she would have otherwise withheld and conceals some favorable revenue news that she would have otherwise revealed. Consequently, in our model, the disclosure region is either two‐tailed or intermediate, in contrast to the single‐tailed disclosure region implied by familiar valuation considerations alone.
Downregulation of ROR2 promotes dental pulp stem cell senescence by inhibiting STK4‐FOXO1/SMS1 axis in sphingomyelin biosynthesis
Authors: Dong Xing‐yue , Huang Yan‐xia , Yang Zhan , Chu Xiao‐yang , Wu Jue , Wang Shan , He Xin , Gao Chun‐Yan , Chen Xu , Yang Kai , Zhang Dong‐liang 
Published: July 2021

AbstractDental pulp stem cells (DPSCs) play a vital role in tooth restoration, regeneration, and homeostasis. The link between DPSC senescence and tooth aging has been well‐recognized. ROR2 plays an important role in aging‐related gene expression. However, the expression and function of ROR2 in DPSC aging remain largely unknown. In this study, we found that ROR2 expression was significantly decreased in aged pulp tissues and DPSCs. The depletion of ROR2 in young DPSCs inhibits their self‐renewal capacity, while its overexpression in aged DPSCs restores their self‐renewal capacity. Interestingly, we found that sphingomyelin (SM) is involved in the senescence of DPSCs regulated by ROR2. Mechanistically, we confirmed that ROR2 inhibited the phosphorylation of STK4, which promoted the translocation of Forkhead Box O1 (FOXO1) to the nucleus. STK4 inhibition or knockdown of FOXO1 markedly increased the proliferation of DPSCs and upregulated the expression of SMS1, which catalyzed SM biogenesis. Moreover, FOXO1 directly bound to the SMS1 promoter, repressing its transcription. Our findings demonstrated the critical role of the ROR2/STK4‐FOXO1/SMS1 axis in the regulation of SM biogenesis and DPSC senescence, providing a novel target for antagonizing tooth aging.
Auditors’ propensity and accuracy in issuing going‐concern modified audit opinions for charities
Authors: Yang Yitang (Jenny) , Simnett Roger , Carson Elizabeth 
Published: July 2021

AbstractThis paper identifies factors contributing to the auditor’s propensity to issue going‐concern modified audit opinions (hereafter, GCOs) for charities and examines their association with subsequent revocation of their charitable status. We find that about 4 percent of charities receive GCOs and these are more likely for those which are smaller, in greater financial distress, received a prior year GCO, and are also affected by dependence on the various types of funding received. After controlling for these factors, Big 4 auditors are less likely to issue GCOs than other audit firms, but there are no differences in their association with subsequent revocation.
A timing momentum strategy
Authors: Lin Chaonan , Yang Nien‐Tzu , Chou Robin K. , Ko Kuan‐Cheng 
Published: July 2021

AbstractWe propose a timing momentum strategy by incorporating moving‐average signals in the price momentum and show that the proposed strategy substantially outperforms the buy‐and‐hold strategy. The performance of the timing momentum is better than that of Barroso and Santa‐Clara’s (2015) constant‐volatility momentum and is identical to that of Daniel and Moskowitz’s (2016) dynamic momentum. One advantage of the timing momentum is that its weights on winner and loser portfolios are lower than the other two strategies, thus leading to lower transaction costs. Further, we show that the profitability of the timing momentum is enhanced when information uncertainty is high. More importantly, the timing momentum has time‐invariant profitability across various time‐series predictors and during periods of momentum crashes.
Cannabis and its therapeutic value in the ageing population: Attitudes of health‐care providers
Authors: Chandiok Karan , Marathe Shreeya , Rooney Miranda , Stocker Jess , Tellis Bianca , Pit Sabrina 
Published: July 2021

AbstractObjective(s)To explore the attitudes of health‐care providers and the perceived barriers and facilitators regarding the use of cannabis‐containing medicines (CCMs) in older patients.MethodsSemi‐structured interviews with eleven health‐care providers in rural New South Wales (NSW). A thematic analysis was performed.ResultsThemes and recommendations include attitudes towards CCMs for therapeutic purposes, their perceived uses, side effects, barriers to use and prescription (stigma, regulation, access and driving), difficulties encountered with the Special Access Scheme (SAS) and the need for ongoing research and education. An ecological framework demonstrated the complex interactions between patients and health‐care providers and their social, community and political environment.ConclusionProviders’ attitudes towards CCM use in older patients are generally positive; however, there is a need for further high‐quality evidence on efficacy and safety, alongside improved CCM education and training, to reduce barriers to their implementation. Barriers to prescription and access continue to evolve on personal, organisational and systemic levels.
Comparison of electrocardiograms (ECG) waveforms and centralized ECG measurements between a simple 6‐lead mobile ECG device and a standard 12‐lead ECG
Authors: Kleiman Robert , Darpo Borje , Brown Randy , Rudo Todd , Chamoun Svetlana , Albert David E. , Bos Johan Martijn , Ackerman Michael J. 
Published: July 2021

AbstractBackgroundInterval duration measurements (IDMs) were compared between standard 12‐lead electrocardiograms (ECGs) and 6‐lead ECGs recorded with AliveCor's KardiaMobile 6L, a hand‐held mobile device designed for use by patients at home.MethodsElectrocardiograms were recorded within, on average, 15 min from 705 patients in Mayo Clinic's Windland Smith Rice Genetic Heart Rhythm Clinic. Interpretable 12‐lead and 6‐lead recordings were available for 685 out of 705 (97%) eligible patients. The most common diagnosis was congenital long QT syndrome (LQTS, 343/685 [50%]), followed by unaffected relatives and patients (146/685 [21%]), and patients with other genetic heart diseases, including hypertrophic cardiomyopathy (36 [5.2%]), arrhythmogenic cardiomyopathy (23 [3.4%]), and idiopathic ventricular fibrillation (14 [2.0%]). IDMs were performed by a central ECG laboratory using lead II with a semi‐automated technique.ResultsDespite differences in patient position (supine for 12‐lead ECGs and sitting for 6‐lead ECGs), mean IDMs were comparable, with mean values for the 12‐lead and 6‐lead ECGs for QTcF, heart rate, PR, and QRS differing by 2.6 ms, −5.5 beats per minute, 1.0 and 1.2 ms, respectively. Despite a modest difference in heart rate, intervals were close enough to allow a detection of clinically meaningful abnormalities.ConclusionsThe 6‐lead hand‐held device is potentially useful for a clinical follow‐up of remote patients, and for a safety follow‐up of patients participating in clinical trials who cannot visit the investigational site. This technology may extend the use of 12‐lead ECG recordings during the current COVID‐19 pandemic as remote patient monitoring becomes more common in virtual or hybrid‐design clinical studies.
Cardiac vagus nerve denervation by pulmonary vein isolation was effective for swallowing‐induced atrial tachycardia
Authors: Yamaguchi Yoshiaki , Sakamoto Tamotsu , Nakatani Yosuke , Mizumaki Koichi 
Published: July 2021

AbstractSwallowing‐induced atrial tachycardia (SIAT) is a relatively rare arrhythmia. A 56‐year‐old woman was admitted to treat atrial tachycardia that occurs by not only eating and drinking but also yawning. Both the right and left upper pulmonary veins were suspected as the earliest activation site of the tachycardia and the abnormal activation of ectopies themselves were suppressed after pulmonary vein isolation (PVI). In a 24‐hour Holter electrocardiogram, the HF component of the analysis of heart rate variability was suppressed both at 1 day and at 2 years after ablation. In this case, cardiac vagal nerve denervation by PVI was effective for SIAT.
Decentring the Lettered City: Exile, Transnational Networks, and Josué de Castro’s Centre International pour le Développement (1964–1973)
Authors: Ferretti Federico 
Published: July 2021

AbstractThis paper discusses the relevance of radical scholarship by exploring the case of the Centre International pour le Développement (CID), founded by Brazilian geographer Josué de Castro during his exile in Paris. Drawing upon Latin American works on the “Lettered City” and the evolving role of intellectuals in constructing critical knowledge, I explore new archives revealing the CID’s daily (net)working. My argument is that this case suggests new interpretations of the notion of Lettered City, exposing slipperiness and potentialities of radical intellectuals’ roles in influencing politics and proposing solutions for global problems. On the one hand, despite Castro’s international renown, the CID failed in its mission of involving politicians and “enlightened” businessmen during the Cold War because its purposes clashed with the interests of most of its interlocutors. On the other, the CID’s archives show that Castro performed a powerful global networking to circulate ideas that still inspire radical geographers.
Presence of high‐risk HLA genotype is the most important individual risk factor for coeliac disease among at‐risk relatives
Authors: Paavola Saana , Lindfors Katri , Kivelä Laura , Cerqueira Juliana , Huhtala Heini , Saavalainen Päivi , Tauschi Riku , Kaukinen Katri , Kurppa Kalle 
Published: July 2021

SummaryBackgroundFamily screening has been advocated as a means to reduce the major underdiagnosis of coeliac disease. However, the precise risk of the disease in relatives and the impact of patient‐ and relative‐related individual factors remain obscure.AimsTo investigate the individual risk of coeliac disease among patients' relatives.MethodsAltogether 2943 relatives of 624 index patients were assessed for the presence of previous coeliac disease diagnosis, or were screened for the disease. Coeliac disease‐associated human leucocyte antigen (HLA) genotype was determined from all participants. The association between individual factors and new screening positivity was assessed by logistic regression.ResultsThere were 229 previously diagnosed non‐index relatives with coeliac disease and 2714 non‐affected (2067 first‐degree, 647 more distant) relatives. Of these 2714 relatives, 129 (4.8%) were screening‐positive (first‐degree 5.1%, second‐degree 3.6%, more distant 3.5%). The combined prevalence of the previously diagnosed and now detected cases in relatives was 12.2% (6.3% clinically detected, 5.9% screen‐detected). In univariate analysis, age <18 years at diagnosis (odds ratio 1.60, 95% CI 1.04‐2.45) in index, and age 41‐60 years (1.73, 1.10‐2.73), being a sibling (1.65, 1.06‐2.59) and having the high‐risk genotype (3.22, 2.01‐5.15 DQ2.5/2.5 or DQ2.5/2.2 vs other risk alleles) in relatives were associated with screening positivity. Only high‐risk HLA remained significant (2.94, 1.80‐4.78) in multivariable analysis.ConclusionsUnrecognised coeliac disease was common among at‐risk relatives even in a country with an active case‐finding policy, and also in relatives more distant than first‐degree. The presence of a high‐risk genotype was the most important predictor for screening positivity. ClinicalTrials.gov identifier NCT03136731.
Sourcing macrolithics: Mineralogical, geochemical and provenance investigation of stone artefacts from Neolithic Avgi, north‐west Greece
Authors: Stergiou Christos L. , Bekiaris Tasos , Melfos Vasilios , Theodoridou Stella , Stratouli Georgia 
Published: July 2021

AbstractThe provenance of the lithic raw materials employed in the production of macrolithic artefacts at Neolithic Avgi (Middle–Late Neolithic, c.5700–4500 cal bce) in Kastoria, north‐western Greece, is studied. Mineralogical, petrographic and geochemical analysis was conducted on selected samples of the archaeological material, supported by geological fieldwork and outcrop sampling. The majority of the macrolithic stone artefacts was manufactured by local raw materials, originating from either the neighbouring ophiolites at Maniakoi or the alluvial sediments of the Aliakmon River and its tributaries. A minor amount of artefacts was produced from ‘exotic’ rocks, such as marble, malachite and amber. The study of two marble artefacts indicates that the raw material is from the island of Naxos in Aegean, although the neighbouring island of Paros is not excluded, suggesting the participation of the Neolithic community of Avgi in social and/or exchange networks.